Not Orphan
Orphan
| Line Number | Ec number | Common Name | Orphan | SwissProt Count | TrEMBL Count | PDB Count | Species Count | Reaction | Systematic Name | Cofactors | Other Names |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.1.1.1 | alcohol dehydrogenase | False | 251 | 44021 | 211 | 138 | (1) a primary alcohol + NAD+ = an aldehyde + NADH + H+;;(2) a secondary alcohol + NAD+ = a ketone + NADH + H+ | alcohol:NAD+ oxidoreductase | None | aldehyde reductase; ADH; alcohol dehydrogenase (NAD); aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD-dependent alcohol dehydrogenase; NAD-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase | |
| 1.1.1.2 | alcohol dehydrogenase (NADP+) | False | 28 | 6380 | 42 | 91 | an alcohol + NADP+ = an aldehyde + NADPH + H+ | alcohol:NADP+ oxidoreductase | None | aldehyde reductase (NADPH2); NADP-alcohol dehydrogenase; NADP+-aldehyde reductase; NADP+-dependent aldehyde reductase; NADPH-aldehyde reductase; NADPH-dependent aldehyde reductase; nonspecific succinic semialdehyde reductase; ALR 1; low-Km aldehyde reductase; high-Km aldehyde reductase; alcohol dehydrogenase (NADP) | |
| 1.1.1.3 | homoserine dehydrogenase | False | 35 | 46786 | 23 | 29 | L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H + H+ | L-homoserine:NAD(P)+ oxidoreductase | None | HSDH; HSD | |
| 1.1.1.4 | (R,R)-butanediol dehydrogenase | False | 6 | 477 | 1 | 37 | (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+ | (R,R)-butane-2,3-diol:NAD+ oxidoreductase | None | butyleneglycol dehydrogenase; D-butanediol dehydrogenase; D-(-)-butanediol dehydrogenase; butylene glycol dehydrogenase; diacetyl (acetoin) reductase; D-aminopropanol dehydrogenase; 1-amino-2-propanol dehydrogenase; 2,3-butanediol dehydrogenase; D-1-amino-2-propanol dehydrogenase; (R)-diacetyl reductase; (R)-2,3-butanediol dehydrogenase; D-1-amino-2-propanol:NAD+ oxidoreductase; 1-amino-2-propanol oxidoreductase; aminopropanol oxidoreductase | |
| 1.1.1.6 | glycerol dehydrogenase | False | 9 | 7230 | 13 | 26 | glycerol + NAD+ = glycerone + NADH + H+ | glycerol:NAD+ 2-oxidoreductase | None | glycerin dehydrogenase; NAD+-linked glycerol dehydrogenase | |
| 1.1.1.7 | propanediol-phosphate dehydrogenase | False | 0 | 12 | 0 | 1 | propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH + H+ | propane-1,2-diol-1-phosphate:NAD+ oxidoreductase | None | PDP dehydrogenase; 1,2-propanediol-1-phosphate:NAD+ oxidoreductase; propanediol phosphate dehydrogenase | |
| 1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) | False | 53 | 8969 | 18 | 44 | sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ | sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase | None | alpha-glycerol phosphate dehydrogenase (NAD+); alpha-glycerophosphate dehydrogenase (NAD+); glycerol 1-phosphate dehydrogenase; glycerol phosphate dehydrogenase (NAD+); glycerophosphate dehydrogenase (NAD+); hydroglycerophosphate dehydrogenase; L-alpha-glycerol phosphate dehydrogenase; L-alpha-glycerophosphate dehydrogenase; L-glycerol phosphate dehydrogenase; L-glycerophosphate dehydrogenase (ambiguous); NAD+-alpha-glycerophosphate dehydrogenase; NAD+-dependent glycerol phosphate dehydrogenase; NAD+-dependent glycerol-3-phosphate dehydrogenase; NAD+-L-glycerol-3-phosphate dehydrogenase; NAD+-linked glycerol 3-phosphate dehydrogenase; NADH-dihydroxyacetone phosphate reductase; glycerol-3-phosphate dehydrogenase (NAD+); L-glycerol-3-phosphate dehydrogenase (ambiguous) | |
| 1.1.1.9 | D-xylulose reductase | False | 31 | 2824 | 1 | 30 | xylitol + NAD+ = D-xylulose + NADH + H+ | xylitol:NAD+ 2-oxidoreductase (D-xylulose-forming) | None | NAD+-dependent xylitol dehydrogenase; xylitol dehydrogenase (ambiguous); erythritol dehydrogenase; 2,3-cis-polyol(DPN) dehydrogenase (C3-5); pentitol-DPN dehydrogenase (ambiguous); xylitol-2-dehydrogenase | |
| 1.1.1.10 | L-xylulose reductase | False | 10 | 300 | 4 | 22 | xylitol + NADP+ = L-xylulose + NADPH + H+ | xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) | None | xylitol dehydrogenase (ambiguous) | |
| 1.1.1.11 | D-arabinitol 4-dehydrogenase | False | 3 | 94 | 0 | 8 | D-arabinitol + NAD+ = D-xylulose + NADH + H+ | D-arabinitol:NAD+ 4-oxidoreductase | None | D-arabitol dehydrogenase; arabitol dehydrogenase | |
| 1.1.1.12 | L-arabinitol 4-dehydrogenase | False | 6 | 1244 | 1 | 11 | L-arabinitol + NAD+ = L-xylulose + NADH + H+ | L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming) | None | pentitol-DPN dehydrogenase (ambiguous); L-arabitol dehydrogenase | |
| 1.1.1.13 | L-arabinitol 2-dehydrogenase | False | 0 | 4 | 0 | 1 | L-arabinitol + NAD+ = L-ribulose + NADH + H+ | L-arabinitol:NAD+ 2-oxidoreductase (L-ribulose-forming) | None | L-arabinitol dehydrogenase (ribulose-forming); L-arabinitol (ribulose-forming) dehydrogenase | |
| 1.1.1.14 | L-iditol 2-dehydrogenase | False | 12 | 4246 | 9 | 29 | L-iditol + NAD+ = L-sorbose + NADH + H+ | L-iditol:NAD+ 2-oxidoreductase | None | polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase | |
| 1.1.1.15 | D-iditol 2-dehydrogenase | False | 1 | 8 | 0 | 3 | D-iditol + NAD+ = D-sorbose + NADH + H+ | D-iditol:NAD+ 2-oxidoreductase | None | D-sorbitol dehydrogenase | |
| 1.1.1.16 | galactitol 2-dehydrogenase | False | 3 | 34 | 3 | 5 | galactitol + NAD+ = D-tagatose + NADH + H+ | galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming) | None | dulcitol dehydrogenase; AtuSorbD (gene name); galactitol:NAD+ 2-oxidoreductase | |
| 1.1.1.17 | mannitol-1-phosphate 5-dehydrogenase | False | 159 | 5570 | 2 | 31 | D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+ | D-mannitol-1-phosphate:NAD+ 5-oxidoreductase | None | hexose reductase; mannitol 1-phosphate dehydrogenase; D-mannitol-1-phosphate dehydrogenase; fructose 6-phosphate reductase | |
| 1.1.1.18 | inositol 2-dehydrogenase | False | 65 | 10412 | 17 | 14 | myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | myo-inositol:NAD+ 2-oxidoreductase | None | myo-inositol 2-dehydrogenase; myo-inositol:NAD+ oxidoreductase; inositol dehydrogenase; myo-inositol dehydrogenase | |
| 1.1.1.19 | glucuronate reductase | False | 7 | 240 | 0 | 9 | L-gulonate + NADP+ = D-glucuronate + NADPH + H+ | L-gulonate:NADP+ 6-oxidoreductase | None | L-hexonate:NADP dehydrogenase; TPN-L-gulonate dehydrogenase; NADP-L-gulonate dehydrogenase; D-glucuronate dehydrogenase; D-glucuronate reductase; L-glucuronate reductase (incorrect) | |
| 1.1.1.20 | glucuronolactone reductase | False | 7 | 249 | 0 | 1 | L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH + H+ | L-gulono-1,4-lactone:NADP+ 1-oxidoreductase | None | GRase; gulonolactone dehydrogenase | |
| 1.1.1.21 | aldose reductase | False | 16 | 2461 | 162 | 33 | alditol + NAD(P)+ = aldose + NAD(P)H + H+ | alditol:NAD(P)+ 1-oxidoreductase | None | polyol dehydrogenase (NADP+); ALR2; alditol:NADP+ oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase; aldehyde reductase (misleading) | |
| 1.1.1.22 | UDP-glucose 6-dehydrogenase | False | 45 | 49904 | 34 | 43 | UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | UDP-alpha-D-glucose:NAD+ 6-oxidoreductase | None | UDP-glucose dehydrogenase; uridine diphosphoglucose dehydrogenase; UDPG dehydrogenase; UDPG:NAD oxidoreductase; UDP-alpha-D-glucose:NAD oxidoreductase; UDP-glucose:NAD+ oxidoreductase; uridine diphosphate glucose dehydrogenase; UDP-D-glucose dehydrogenase; uridine diphosphate D-glucose dehydrogenase | |
| 1.1.1.23 | histidinol dehydrogenase | False | 220 | 39796 | 11 | 20 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+ | L-histidinol:NAD+ oxidoreductase | None | L-histidinol dehydrogenase | |
| 1.1.1.24 | quinate/shikimate dehydrogenase (NAD+) | False | 5 | 27 | 3 | 17 | L-quinate + NAD+ = 3-dehydroquinate + NADH + H+ | L-quinate:NAD+ 3-oxidoreductase | None | quinate dehydrogenase (ambiguous); quinic dehydrogenase (ambiguous); quinate:NAD oxidoreductase; quinate 5-dehydrogenase (ambiguous); quinate:NAD+ 5-oxidoreductase | |
| 1.1.1.25 | shikimate dehydrogenase (NADP+) | False | 537 | 41397 | 43 | 40 | shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+ | shikimate:NADP+ 3-oxidoreductase | None | shikimate dehydrogenase; dehydroshikimic reductase; shikimate oxidoreductase; shikimate:NADP+ oxidoreductase; 5-dehydroshikimate reductase; shikimate 5-dehydrogenase; 5-dehydroshikimic reductase; DHS reductase; shikimate:NADP+ 5-oxidoreductase; AroE | |
| 1.1.1.26 | glyoxylate reductase | False | 12 | 1173 | 5 | 17 | glycolate + NAD+ = glyoxylate + NADH + H+ | glycolate:NAD+ oxidoreductase | None | NADH-glyoxylate reductase; glyoxylic acid reductase; NADH-dependent glyoxylate reductase | |
| 1.1.1.27 | L-lactate dehydrogenase | False | 311 | 17017 | 178 | 143 | (S)-lactate + NAD+ = pyruvate + NADH + H+ | (S)-lactate:NAD+ oxidoreductase | None | lactic acid dehydrogenase; L(+)-nLDH; L-(+)-lactate dehydrogenase; L-lactic dehydrogenase; L-lactic acid dehydrogenase; lactate dehydrogenase; lactate dehydrogenase NAD+-dependent; lactic dehydrogenase; NAD+-lactate dehydrogenase | |
| 1.1.1.28 | D-lactate dehydrogenase | False | 22 | 2914 | 15 | 70 | (R)-lactate + NAD+ = pyruvate + NADH + H+ | (R)-lactate:NAD+ oxidoreductase | None | lactic acid dehydrogenase; lactic acid dehydrogenase; D-specific lactic dehydrogenase; D-(-)-lactate dehydrogenase (NAD+); D-lactic acid dehydrogenase; D-lactic dehydrogenase | |
| 1.1.1.29 | glycerate dehydrogenase | False | 5 | 2408 | 1 | 15 | D-glycerate + NAD+ = hydroxypyruvate + NADH + H+ | D-glycerate:NAD+ oxidoreductase | None | D-glycerate dehydrogenase; hydroxypyruvate reductase; (R)-glycerate:NAD+ oxidoreductase | |
| 1.1.1.30 | 3-hydroxybutyrate dehydrogenase | False | 15 | 8268 | 21 | 25 | (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+ | (R)-3-hydroxybutanoate:NAD+ oxidoreductase | None | NAD-beta-hydroxybutyrate dehydrogenase; hydroxybutyrate oxidoreductase; beta-hydroxybutyrate dehydrogenase; D-beta-hydroxybutyrate dehydrogenase; D-3-hydroxybutyrate dehydrogenase; D-(-)-3-hydroxybutyrate dehydrogenase; beta-hydroxybutyric acid dehydrogenase; 3-D-hydroxybutyrate dehydrogenase; beta-hydroxybutyric dehydrogenase | |
| 1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase | False | 18 | 15090 | 17 | 24 | 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+ | 3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase | None | beta-hydroxyisobutyrate dehydrogenase | |
| 1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) | False | 65 | 9427 | 31 | 86 | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating) | None | hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous); beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous); hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous); NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2) | |
| 1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase | False | 226 | 12898 | 60 | 23 | (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+ | (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase | None | beta-hydroxyacyl dehydrogenase; beta-keto-reductase; 3-keto reductase; 3-hydroxyacyl coenzyme A dehydrogenase; beta-hydroxyacyl-coenzyme A synthetase; beta-hydroxyacylcoenzyme A dehydrogenase; beta-hydroxybutyrylcoenzyme A dehydrogenase; 3-hydroxyacetyl-coenzyme A dehydrogenase; L-3-hydroxyacyl coenzyme A dehydrogenase; L-3-hydroxyacyl CoA dehydrogenase; beta-hydroxyacyl CoA dehydrogenase; 3beta-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxybutyryl-CoA dehydrogenase; beta-ketoacyl-CoA reductase; beta-hydroxy acid dehydrogenase; 3-L-hydroxyacyl-CoA dehydrogenase; 3-hydroxyisobutyryl-CoA dehydrogenase; 1-specific DPN-linked beta-hydroxybutyric dehydrogenase | |
| 1.1.1.36 | acetoacetyl-CoA reductase | False | 9 | 5264 | 15 | 30 | (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+ | (R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase | None | acetoacetyl coenzyme A reductase; hydroxyacyl coenzyme-A dehydrogenase; NADP-linked acetoacetyl CoA reductase; NADPH:acetoacetyl-CoA reductase; D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase; short chain beta-ketoacetyl(acetoacetyl)-CoA reductase; beta-ketoacyl-CoA reductase; D-3-hydroxyacyl-CoA reductase; (R)-3-hydroxyacyl-CoA dehydrogenase | |
| 1.1.1.37 | malate dehydrogenase | False | 593 | 50580 | 104 | 172 | (S)-malate + NAD+ = oxaloacetate + NADH + H+ | (S)-malate:NAD+ oxidoreductase | None | malic dehydrogenase; L-malate dehydrogenase; NAD-L-malate dehydrogenase; malic acid dehydrogenase; NAD-dependent malic dehydrogenase; NAD-malate dehydrogenase; NAD-malic dehydrogenase; malate (NAD) dehydrogenase; NAD-dependent malate dehydrogenase; NAD-specific malate dehydrogenase; NAD-linked malate dehydrogenase; MDH (ambiguous); L-malate-NAD+ oxidoreductase | |
| 1.1.1.38 | malate dehydrogenase (oxaloacetate-decarboxylating) | False | 119 | 6060 | 15 | 28 | (1) (S)-malate + NAD+ = pyruvate + CO2 + NADH;;(2) oxaloacetate = pyruvate + CO2 | (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) | None | 'malic' enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); NAD+-specific malic enzyme; NAD+-malic enzyme; NAD+-linked malic enzyme | |
| 1.1.1.39 | malate dehydrogenase (decarboxylating) | False | 6 | 189 | 7 | 56 | (S)-malate + NAD+ = pyruvate + CO2 + NADH | (S)-malate:NAD+ oxidoreductase (decarboxylating) | None | 'malic' enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); NAD-specific malic enzyme (ambiguous); NAD-malic enzyme (ambiguous); malate dehydrogenase (decarboxylating) (ambiguous) | |
| 1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) | False | 32 | 9217 | 23 | 112 | (1) (S)-malate + NADP+ = pyruvate + CO2 + NADPH;;(2) oxaloacetate = pyruvate + CO2 | (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating) | None | 'malic' enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); malate dehydrogenase (decarboxylating, NADP+); NADP+-linked decarboxylating malic enzyme; NADP+-malic enzyme; NADP+-specific malic enzyme; NADP+-specific malate dehydrogenase; malate dehydrogenase (NADP+, decarboxylating); L-malate:NADP+ oxidoreductase | |
| 1.1.1.41 | isocitrate dehydrogenase (NAD+) | False | 25 | 5041 | 22 | 54 | isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH | isocitrate:NAD+ oxidoreductase (decarboxylating) | None | isocitric dehydrogenase; beta-ketoglutaric-isocitric carboxylase; isocitric acid dehydrogenase; NAD dependent isocitrate dehydrogenase; NAD isocitrate dehydrogenase; NAD-linked isocitrate dehydrogenase; NAD-specific isocitrate dehydrogenase; NAD isocitric dehydrogenase; isocitrate dehydrogenase (NAD); IDH (ambiguous); nicotinamide adenine dinucleotide isocitrate dehydrogenase | |
| 1.1.1.42 | isocitrate dehydrogenase (NADP+) | False | 69 | 50380 | 140 | 85 | isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction);;(1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+;;(1b) oxalosuccinate = 2-oxoglutarate + CO2 | isocitrate:NADP+ oxidoreductase (decarboxylating) | None | oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3 | |
| 1.1.1.43 | phosphogluconate 2-dehydrogenase | False | 0 | 37 | 0 | 27 | 6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ | 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase | None | 6-phosphogluconic dehydrogenase; phosphogluconate dehydrogenase; gluconate 6-phosphate dehydrogenase; 6-phosphogluconate dehydrogenase (NAD+); 2-keto-6-phosphogluconate reductase | |
| 1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) | False | 62 | 27824 | 29 | 74 | 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+ | 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) | None | phosphogluconic acid dehydrogenase; 6-phosphogluconic dehydrogenase; 6-phosphogluconic carboxylase; 6-phosphogluconate dehydrogenase (decarboxylating); 6-phospho-D-gluconate dehydrogenase | |
| 1.1.1.45 | L-gulonate 3-dehydrogenase | False | 7 | 1598 | 2 | 8 | L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ | L-gulonate:NAD+ 3-oxidoreductase | None | L-3-aldonate dehydrogenase; L-3-aldonic dehydrogenase; L-gulonic acid dehydrogenase; L-beta-hydroxyacid dehydrogenase; L-beta-hydroxy-acid-NAD+-oxidoreductase; L-3-hydroxyacid dehydrogenase | |
| 1.1.1.46 | L-arabinose 1-dehydrogenase | False | 0 | 125 | 0 | 2 | L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH + H+ | L-arabinose:NAD+ 1-oxidoreductase | None | None | |
| 1.1.1.47 | glucose 1-dehydrogenase [NAD(P)+] | False | 31 | 26029 | 29 | 32 | D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+ | D-glucose:NAD(P)+ 1-oxidoreductase | None | D-glucose dehydrogenase (NAD(P)+); hexose phosphate dehydrogenase; beta-D-glucose:NAD(P)+ 1-oxidoreductase; glucose 1-dehydrogenase | |
| 1.1.1.48 | D-galactose 1-dehydrogenase | False | 4 | 295 | 1 | 7 | D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ | D-galactose:NAD+ 1-oxidoreductase | None | D-galactose dehydrogenase; beta-galactose dehydrogenase (ambiguous); NAD+-dependent D-galactose dehydrogenase | |
| 1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) | False | 73 | 40863 | 47 | 68 | D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | D-glucose-6-phosphate:NADP+ 1-oxidoreductase | None | NADP-glucose-6-phosphate dehydrogenase; Zwischenferment; D-glucose 6-phosphate dehydrogenase; glucose 6-phosphate dehydrogenase (NADP); NADP-dependent glucose 6-phosphate dehydrogenase; 6-phosphoglucose dehydrogenase; Entner-Doudoroff enzyme; glucose-6-phosphate 1-dehydrogenase; G6PDH; GPD; glucose-6-phosphate dehydrogenase | |
| 1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) | False | 3 | 306 | 5 | 16 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ | 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific) | None | hydroxyprostaglandin dehydrogenase; 3alpha-hydroxysteroid oxidoreductase; sterognost 3alpha; 3alpha-hydroxysteroid dehydrogenase (B-specific); 3alpha-hydroxysteroid 3-dehydrogenase (B-specific); 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific) | |
| 1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase | False | 13 | 188 | 2 | 17 | testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ | 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase | None | beta-hydroxy steroid dehydrogenase; 17-ketoreductase; 17beta-hydroxy steroid dehydrogenase; 3beta-hydroxysteroid dehydrogenase; 3beta-hydroxy steroid dehydrogenase | |
| 1.1.1.52 | 3alpha-hydroxycholanate dehydrogenase (NAD+) | False | 1 | 6 | 1 | 1 | lithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+ | lithocholate:NAD+ 3-oxidoreductase | None | alpha-hydroxy-cholanate dehydrogenase; lithocholate:NAD+ oxidoreductase; 3alpha-hydroxycholanate dehydrogenase | |
| 1.1.1.53 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase | False | 33 | 873 | 6 | 17 | androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ | 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase | None | cortisone reductase; (R)-20-hydroxysteroid dehydrogenase; 20beta-hydroxy steroid dehydrogenase; Delta4-3-ketosteroid hydrogenase; 20beta-hydroxysteroid dehydrogenase; 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase; NADH-20beta-hydroxysteroid dehydrogenase; 20beta-HSD | |
| 1.1.1.54 | allyl-alcohol dehydrogenase | False | 16 | 234 | 0 | 5 | allyl alcohol + NADP+ = acrolein + NADPH + H+ | allyl-alcohol:NADP+ oxidoreductase | None | None | |
| 1.1.1.55 | lactaldehyde reductase (NADPH) | False | 0 | 5 | 0 | 3 | propane-1,2-diol + NADP+ = L-lactaldehyde + NADPH + H+ | propane-1,2-diol:NADP+ oxidoreductase | None | lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADP+-1,2-propanediol dehydrogenase; propanediol dehydrogenase; 1,2-propanediol:NADP+ oxidoreductase; lactaldehyde reductase (NADPH) | |
| 1.1.1.56 | ribitol 2-dehydrogenase | False | 3 | 398 | 0 | 8 | ribitol + NAD+ = D-ribulose + NADH + H+ | ribitol:NAD+ 2-oxidoreductase | None | adonitol dehydrogenase; ribitol dehydrogenase A (wild type); ribitol dehydrogenase B (mutant enzyme with different properties); ribitol dehydrogenase D (mutant enzyme with different properties) | |
| 1.1.1.57 | fructuronate reductase | False | 2 | 1783 | 0 | 1 | D-mannonate + NAD+ = D-fructuronate + NADH + H+ | D-mannonate:NAD+ 5-oxidoreductase | None | mannonate oxidoreductase; mannonic dehydrogenase; D-mannonate dehydrogenase; D-mannonate:NAD+ oxidoreductase | |
| 1.1.1.58 | tagaturonate reductase | False | 38 | 2539 | 0 | 3 | D-altronate + NAD+ = D-tagaturonate + NADH + H+ | D-altronate:NAD+ 3-oxidoreductase | None | altronic oxidoreductase; altronate oxidoreductase; TagUAR; altronate dehydrogenase; D-tagaturonate reductase | |
| 1.1.1.59 | 3-hydroxypropionate dehydrogenase | False | 0 | 6 | 0 | 14 | 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+ | 3-hydroxypropanoate:NAD+ oxidoreductase | None | None | |
| 1.1.1.60 | 2-hydroxy-3-oxopropionate reductase | False | 3 | 7712 | 2 | 7 | D-glycerate + NAD(P)+ = 2-hydroxy-3-oxopropanoate + NAD(P)H + H+ | D-glycerate:NAD(P)+ oxidoreductase | None | tartronate semialdehyde reductase; (R)-glycerate:NAD(P)+ oxidoreductase | |
| 1.1.1.61 | 4-hydroxybutyrate dehydrogenase | False | 3 | 102 | 0 | 6 | 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+ | 4-hydroxybutanoate:NAD+ oxidoreductase | None | gamma-hydroxybutyrate dehydrogenase | |
| 1.1.1.62 | 17beta-estradiol 17-dehydrogenase | False | 66 | 1974 | 46 | 20 | 17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ | 17beta-estradiol:NAD(P)+ 17-oxidoreductase | None | 20alpha-hydroxysteroid dehydrogenase; 17beta,20alpha-hydroxysteroid dehydrogenase; 17beta-estradiol dehydrogenase; estradiol dehydrogenase; estrogen 17-oxidoreductase; 17beta-HSD; HSD17B7 | |
| 1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) | False | 7 | 13 | 6 | 9 | testosterone + NADP+ = androstenedione + NADPH + H+ | 17beta-hydroxysteroid:NADP+ 17-oxidoreductase | None | 17-ketoreductase; NADP-dependent testosterone-17beta-oxidoreductase; testosterone 17beta-dehydrogenase (NADP) | |
| 1.1.1.65 | pyridoxine 4-dehydrogenase | False | 5 | 434 | 0 | 2 | pyridoxine + NADP+ = pyridoxal + NADPH + H+ | pyridoxine:NADP+ 4-oxidoreductase | None | pyridoxin dehydrogenase; pyridoxol dehydrogenase; pyridoxine dehydrogenase | |
| 1.1.1.66 | omega-hydroxydecanoate dehydrogenase | False | 3 | 0 | 0 | 5 | 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH + H+ | 10-hydroxydecanoate:NAD+ 10-oxidoreductase | None | None | |
| 1.1.1.67 | mannitol 2-dehydrogenase | False | 14 | 1487 | 4 | 32 | D-mannitol + NAD+ = D-fructose + NADH + H+ | D-mannitol:NAD+ 2-oxidoreductase | None | D-mannitol dehydrogenase; mannitol dehydrogenase | |
| 1.1.1.69 | gluconate 5-dehydrogenase | False | 2 | 4834 | 4 | 23 | D-gluconate + NAD(P)+ = 5-dehydro-D-gluconate + NAD(P)H + H+ | D-gluconate:NAD(P)+ 5-oxidoreductase | None | 5-keto-D-gluconate 5-reductase; 5-keto-D-gluconate 5-reductase; 5-ketogluconate 5-reductase; 5-ketogluconate reductase; 5-keto-D-gluconate reductase | |
| 1.1.1.71 | alcohol dehydrogenase [NAD(P)+] | False | 8 | 51 | 0 | 35 | an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+ | alcohol:NAD(P)+ oxidoreductase | None | retinal reductase (ambiguous); aldehyde reductase (NADPH/NADH); alcohol dehydrogenase [NAD(P)] | |
| 1.1.1.72 | glycerol dehydrogenase (NADP+) | False | 1 | 4 | 0 | 12 | glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ | glycerol:NADP+ oxidoreductase | None | glycerol dehydrogenase (NADP) | |
| 1.1.1.73 | octanol dehydrogenase | False | 1 | 10 | 0 | 11 | octan-1-ol + NAD+ = octanal + NADH + H+ | octan-1-ol:NAD+ oxidoreductase | None | 1-octanol dehydrogenase; octanol:NAD+ oxidoreductase | |
| 1.1.1.75 | (R)-aminopropanol dehydrogenase | False | 1 | 6 | 0 | 5 | (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+ | (R)-1-aminopropan-2-ol:NAD+ oxidoreductase | None | L-aminopropanol dehydrogenase; 1-aminopropan-2-ol-NAD+ dehydrogenase; L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase; 1-aminopropan-2-ol-dehydrogenase; DL-1-aminopropan-2-ol: NAD+ dehydrogenase; L(+)-1-aminopropan-2-ol-NAD+/NADP+ oxidoreductase | |
| 1.1.1.76 | (S,S)-butanediol dehydrogenase | False | 1 | 256 | 0 | 14 | (2S,3S)-butane-2,3-diol + NAD+ = (S)-acetoin + NADH + H+ | (S,S)-butane-2,3-diol:NAD+ oxidoreductase | None | L-butanediol dehydrogenase; L-BDH; L(+)-2,3-butanediol dehydrogenase (L-acetoin forming); (S)-acetoin reductase [(S,S)-butane-2,3-diol forming] | |
| 1.1.1.77 | lactaldehyde reductase | False | 2 | 2972 | 14 | 6 | (R)[or (S)]-propane-1,2-diol + NAD+ = (R)[or (S)]-lactaldehyde + NADH + H+ | (R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase | None | propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase; L-lactaldehyde:propanediol oxidoreductase | |
| 1.1.1.78 | methylglyoxal reductase (NADH) | False | 1 | 0 | 0 | 6 | (R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+ | (R)-lactaldehyde:NAD+ oxidoreductase | None | methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent) | |
| 1.1.1.79 | glyoxylate reductase (NADP+) | False | 118 | 5533 | 17 | 21 | glycolate + NADP+ = glyoxylate + NADPH + H+ | glycolate:NADP+ oxidoreductase | None | NADPH-glyoxylate reductase; glyoxylate reductase (NADP) | |
| 1.1.1.80 | isopropanol dehydrogenase (NADP+) | False | 4 | 152 | 8 | 5 | propan-2-ol + NADP+ = acetone + NADPH + H+ | propan-2-ol:NADP+ oxidoreductase | None | isopropanol dehydrogenase (NADP+) | |
| 1.1.1.81 | hydroxypyruvate reductase | False | 119 | 5398 | 5 | 29 | D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H + H+ | D-glycerate:NADP+ 2-oxidoreductase | None | beta-hydroxypyruvate reductase; NADH:hydroxypyruvate reductase; D-glycerate dehydrogenase | |
| 1.1.1.82 | malate dehydrogenase (NADP+) | False | 10 | 515 | 2 | 50 | (S)-malate + NADP+ = oxaloacetate + NADPH + H+ | (S)-malate:NADP+ oxidoreductase | None | NADP+-malic enzyme; NADP+-malate dehydrogenase; malic dehydrogenase (nicotinamide adenine dinucleotide phosphate); malate NADP+ dehydrogenase; NADP+ malate dehydrogenase; NADP+-linked malate dehydrogenase; malate dehydrogenase (NADP+) | |
| 1.1.1.83 | D-malate dehydrogenase (decarboxylating) | False | 9 | 10307 | 0 | 7 | (R)-malate + NAD+ = pyruvate + CO2 + NADH | (R)-malate:NAD+ oxidoreductase (decarboxylating) | None | D-malate dehydrogenase; D-malic enzyme; bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating) | |
| 1.1.1.84 | dimethylmalate dehydrogenase | True | 0 | 0 | 0 | 2 | (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH | (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating) | None | beta,beta-dimethylmalate dehydrogenase | |
| 1.1.1.85 | 3-isopropylmalate dehydrogenase | False | 305 | 37784 | 54 | 42 | (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH + H+ (overall reaction);;(1a) (2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+;;(1b) (2S)-2-isopropyl-3-oxosuccinate = 4-methyl-2-oxopentanoate + CO2 (spontaneous) | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase | None | beta-isopropylmalic enzyme; beta-isopropylmalate dehydrogenase; threo-Ds-3-isopropylmalate dehydrogenase; 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase | |
| 1.1.1.86 | ketol-acid reductoisomerase (NADP+) | False | 642 | 36927 | 55 | 41 | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ | (2R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | None | dihydroxyisovalerate dehydrogenase (isomerizing); acetohydroxy acid isomeroreductase; ketol acid reductoisomerase; alpha-keto-beta-hydroxylacyl reductoisomerase; 2-hydroxy-3-keto acid reductoisomerase; acetohydroxy acid reductoisomerase; acetolactate reductoisomerase; dihydroxyisovalerate (isomerizing) dehydrogenase; isomeroreductase; reductoisomerase; ketol-acid reductoisomerase; (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | |
| 1.1.1.87 | homoisocitrate dehydrogenase | False | 3 | 400 | 5 | 11 | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating) | None | 2-hydroxy-3-carboxyadipate dehydrogenase; 3-carboxy-2-hydroxyadipate dehydrogenase; homoisocitric dehydrogenase; (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating); 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating); HICDH | |
| 1.1.1.88 | hydroxymethylglutaryl-CoA reductase | False | 2 | 5460 | 21 | 12 | (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating) | None | beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous); beta-hydroxy-beta-methylglutaryl CoA-reductase (ambiguous); 3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous); hydroxymethylglutaryl coenzyme A reductase (ambiguous) | |
| 1.1.1.90 | aryl-alcohol dehydrogenase | False | 2 | 452 | 1 | 23 | an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+ | aryl-alcohol:NAD+ oxidoreductase | None | p-hydroxybenzyl alcohol dehydrogenase; benzyl alcohol dehydrogenase; coniferyl alcohol dehydrogenase | |
| 1.1.1.91 | aryl-alcohol dehydrogenase (NADP+) | False | 1 | 410 | 0 | 25 | an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH + H+ | aryl-alcohol:NADP+ oxidoreductase | None | aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate); coniferyl alcohol dehydrogenase; NADPH-linked benzaldehyde reductase; aryl-alcohol dehydrogenase (NADP+) | |
| 1.1.1.92 | oxaloglycolate reductase (decarboxylating) | True | 0 | 0 | 0 | 1 | D-glycerate + NAD(P)+ + CO2 = 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H+ | D-glycerate:NAD(P)+ oxidoreductase (carboxylating) | None | None | |
| 1.1.1.93 | tartrate dehydrogenase | False | 7 | 2729 | 2 | 3 | tartrate + NAD+ = oxaloglycolate + NADH + H+ | tartrate:NAD+ oxidoreductase | None | mesotartrate dehydrogenase | |
| 1.1.1.94 | glycerol-3-phosphate dehydrogenase [NAD(P)+] | False | 593 | 38624 | 2 | 5 | sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ | sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase | None | L-glycerol-3-phosphate:NAD(P) oxidoreductase; glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)); glycerol 3-phosphate dehydrogenase (NADP); glycerol-3-phosphate dehydrogenase [NAD(P)] | |
| 1.1.1.95 | phosphoglycerate dehydrogenase | False | 29 | 38918 | 40 | 39 | 3-phospho-D-glycerate + NAD+ = 3-phosphooxypyruvate + NADH + H+ | 3-phospho-D-glycerate:NAD+ 2-oxidoreductase | None | PHGDH (gene name); D-3-phosphoglycerate:NAD+ oxidoreductase; alpha-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD+ 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase | |
| 1.3.98.4 | 5a,11a-dehydrotetracycline reductase | False | 1 | 5 | 0 | 1 | tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420 | tetracycline:coenzyme F420 dehydrogenase | None | oxyR (gene name); 12-dehydrotetracycline dehydrogenase; dehydrooxytetracycline dehydrogenase; 12-dehydrotetracycline reductase | |
| 1.1.1.96 | diiodophenylpyruvate reductase | False | 6 | 56 | 0 | 4 | 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+ | 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase | None | aromatic alpha-keto acid; KAR; 2-oxo acid reductase | |
| 1.1.1.97 | 3-hydroxybenzyl-alcohol dehydrogenase | True | 0 | 0 | 0 | 2 | 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + NADPH + H+ | 3-hydroxybenzyl-alcohol:NADP+ oxidoreductase | None | m-hydroxybenzyl alcohol dehydrogenase; m-hydroxybenzyl alcohol (NADP+) dehydrogenase; m-hydroxybenzylalcohol dehydrogenase | |
| 1.1.1.98 | (R)-2-hydroxy-fatty-acid dehydrogenase | True | 0 | 0 | 0 | 2 | (R)-2-hydroxystearate + NAD+ = 2-oxostearate + NADH + H+ | (R)-2-hydroxystearate:NAD+ oxidoreductase | None | D-2-hydroxy fatty acid dehydrogenase; 2-hydroxy fatty acid oxidase | |
| 1.1.1.99 | (S)-2-hydroxy-fatty-acid dehydrogenase | True | 0 | 0 | 0 | 2 | (S)-2-hydroxystearate + NAD+ = 2-oxostearate + NADH + H+ | (S)-2-hydroxystearate:NAD+ oxidoreductase | None | dehydrogenase, L-2-hydroxy fatty acid; L-2-hydroxy fatty acid dehydrogenase; 2-hydroxy fatty acid oxidase | |
| 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | False | 75 | 71578 | 141 | 50 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ | (3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase | None | beta-ketoacyl-[acyl-carrier protein](ACP) reductase; beta-ketoacyl acyl carrier protein (ACP) reductase; beta-ketoacyl reductase; beta-ketoacyl thioester reductase; beta-ketoacyl-ACP reductase; beta-ketoacyl-acyl carrier protein reductase; 3-ketoacyl acyl carrier protein reductase; NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase; 3-oxoacyl-[ACP]reductase; (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase | |
| 1.1.1.101 | acylglycerone-phosphate reductase | False | 2 | 66 | 0 | 6 | 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+ | 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase | None | palmitoyldihydroxyacetone-phosphate reductase; palmitoyl dihydroxyacetone phosphate reductase; palmitoyl-dihydroxyacetone-phosphate reductase; acyldihydroxyacetone phosphate reductase; palmitoyl dihydroxyacetone phosphate reductase | |
| 1.1.1.102 | 3-dehydrosphinganine reductase | False | 21 | 4704 | 1 | 10 | sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+ | D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase | None | D-3-dehydrosphinganine reductase; D-3-oxosphinganine reductase; DSR; 3-oxosphinganine reductase; 3-oxosphinganine:NADPH oxidoreductase; D-3-oxosphinganine:B-NADPH oxidoreductase | |
| 1.1.1.103 | L-threonine 3-dehydrogenase | False | 187 | 11301 | 28 | 24 | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ | L-threonine:NAD+ oxidoreductase | None | L-threonine dehydrogenase; threonine 3-dehydrogenase; threonine dehydrogenase; TDH | |
| 1.1.1.104 | 4-oxoproline reductase | False | 7 | 990 | 0 | 1 | cis-4-hydroxy-L-proline + NAD+ = 4-oxo-L-proline + NADH + H+ | cis-4-hydroxy-L-proline:NAD+ oxidoreductase (4-oxo-L-proline forming) | None | cis-hydroxy-L-proline oxidase | |
| 1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) | False | 32 | 112 | 0 | 12 | all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+ | all-trans retinol:NAD+ oxidoreductase | None | retinol (vitamin A1) dehydrogenase; MDR; microsomal retinol dehydrogenase; retinol dehydrogenase (misleading); retinal reductase (ambiguous); retinene reductase; epidermal retinol dehydrogenase 2; SDR16C5 (gene name); RDH16 (gene name) | |
| 1.1.1.106 | pantoate 4-dehydrogenase | True | 0 | 0 | 0 | 2 | (R)-pantoate + NAD+ = (R)-4-dehydropantoate + NADH + H+ | (R)-pantoate:NAD+ 4-oxidoreductase | None | pantoate dehydrogenase; pantothenase; D-pantoate:NAD+ 4-oxidoreductase | |
| 1.1.1.107 | pyridoxal 4-dehydrogenase | False | 2 | 672 | 3 | 5 | pyridoxal + NAD+ = 4-pyridoxolactone + NADH + H+ | pyridoxal:NAD+ 4-oxidoreductase | None | pyridoxal dehydrogenase | |
| 1.1.1.108 | carnitine 3-dehydrogenase | False | 17 | 3613 | 0 | 8 | carnitine + NAD+ = 3-dehydrocarnitine + NADH + H+ | carnitine:NAD+ 3-oxidoreductase | None | None | |
| 1.1.1.110 | aromatic 2-oxoacid reductase | False | 2 | 0 | 0 | 3 | (1) (R)-3-(phenyl)lactate + NAD+ = 3-phenylpyruvate + NADH + H+;;(2) (R)-3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+;;(3) (R)-(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+ | aromatic 2-oxoacid:NAD+ oxidoreductase | None | (R)-aromatic lactate dehydrogenase; (R)-4-hydroxyphenyllactate dehydrogenase; indolelactate:NAD+ oxidoreductase; indolelactate dehydrogenase; fldH (gene name); (indol-3-yl)lactate:NAD+ oxidoreductase | |
| 1.1.1.111 | 3-(imidazol-5-yl)lactate dehydrogenase | True | 0 | 0 | 0 | 1 | (S)-3-(imidazol-5-yl)lactate + NAD(P)+ = 3-(imidazol-5-yl)pyruvate + NAD(P)H + H+ | (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase | None | imidazol-5-yl lactate dehydrogenase | |
| 1.1.1.112 | indanol dehydrogenase | False | 5 | 7 | 0 | 4 | indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+ | indan-1-ol:NAD(P)+ 1-oxidoreductase | None | None | |
| 1.1.1.113 | L-xylose 1-dehydrogenase | False | 0 | 3 | 0 | 3 | L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH + H+ | L-xylose:NADP+ 1-oxidoreductase | None | L-xylose dehydrogenase; NADPH-xylose reductase | |
| 1.1.1.114 | apiose 1-reductase | False | 0 | 1 | 0 | 2 | D-apiitol + NAD+ = D-apiose + NADH + H+ | D-apiitol:NAD+ 1-oxidoreductase | None | D-apiose reductase; D-apiitol reductase | |
| 1.1.1.115 | ribose 1-dehydrogenase (NADP+) | True | 0 | 0 | 0 | 3 | D-ribose + NADP+ + H2O = D-ribonate + NADPH + H+ | D-ribose:NADP+ 1-oxidoreductase | None | D-ribose dehydrogenase (NADP+); NADP+-pentose-dehydrogenase; ribose 1-dehydrogenase (NADP+) | |
| 1.1.1.116 | D-arabinose 1-dehydrogenase (NAD+) | False | 1 | 21 | 0 | 6 | D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH + H+ | D-arabinose:NAD+ 1-oxidoreductase | None | NAD+-pentose-dehydrogenase; arabinose(fucose)dehydrogenase | |
| 1.1.1.117 | D-arabinose 1-dehydrogenase [NAD(P)+] | False | 1 | 9 | 3 | 4 | D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+ | D-arabinose:NAD(P)+ 1-oxidoreductase | None | D-arabinose 1-dehydrogenase [NAD(P)] | |
| 1.1.1.118 | glucose 1-dehydrogenase (NAD+) | False | 0 | 0 | 5 | 7 | D-glucose + NAD+ = D-glucono-1,5-lactone + NADH + H+ | D-glucose:NAD+ 1-oxidoreductase | None | D-glucose:NAD oxidoreductase; D-aldohexose dehydrogenase; glucose 1-dehydrogenase (NAD) | |
| 1.1.1.119 | glucose 1-dehydrogenase (NADP+) | False | 1 | 104 | 0 | 11 | D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH + H+ | D-glucose:NADP+ 1-oxidoreductase | None | nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase; NADP+-linked aldohexose dehydrogenase; NADP+-dependent glucose dehydrogenase; glucose 1-dehydrogenase (NADP+) | |
| 1.1.1.120 | galactose 1-dehydrogenase (NADP+) | False | 3 | 25 | 0 | 4 | D-galactose + NADP+ = D-galactono-1,5-lactone + NADPH + H+ | D-galactose:NADP+ 1-oxidoreductase | None | D-galactose dehydrogenase (NADP+); galactose 1-dehydrogenase (NADP) | |
| 1.1.1.121 | aldose 1-dehydrogenase (NAD+) | True | 0 | 0 | 0 | 5 | D-aldose + NAD+ = D-aldonolactone + NADH + H+ | D-aldose:NAD+ 1-oxidoreductase | None | aldose dehydrogenase; D-aldohexose dehydrogenase; aldose 1-dehydrogenase | |
| 1.1.1.122 | D-threo-aldose 1-dehydrogenase | False | 1 | 992 | 0 | 9 | a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH + H+ | D-threo-aldose:NAD+ 1-oxidoreductase | None | L-fucose dehydrogenase; (2S,3R)-aldose dehydrogenase; dehydrogenase, L-fucose; L-fucose (D-arabinose) dehydrogenase | |
| 1.1.1.123 | sorbose 5-dehydrogenase (NADP+) | False | 0 | 5 | 0 | 13 | L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH + H+ | L-sorbose:NADP+ 5-oxidoreductase | None | 5-ketofructose reductase; 5-keto-D-fructose reductase; sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase; reduced nicotinamide adenine dinucleotide phosphate-linked reductase; sorbose 5-dehydrogenase (NADP+) | |
| 1.1.1.124 | fructose 5-dehydrogenase (NADP+) | False | 1 | 0 | 0 | 3 | D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH + H+ | D-fructose:NADP+ 5-oxidoreductase | None | 5-ketofructose reductase (NADP+); 5-keto-D-fructose reductase (NADP+); fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase; D-(-)fructose:(NADP+) 5-oxidoreductase; fructose 5-dehydrogenase (NADP+) | |
| 1.1.1.125 | 2-deoxy-D-gluconate 3-dehydrogenase | False | 0 | 1088 | 4 | 2 | 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+ | 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase | None | 2-deoxygluconate dehydrogenase | |
| 1.1.1.126 | 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase | False | 0 | 0 | 2 | 2 | 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H+ | 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase | None | 2-keto-3-deoxy-D-gluconate dehydrogenase (ambiguous); 2-keto-3-deoxygluconate dehydrogenase (ambiguous) | |
| 1.1.1.127 | 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase | False | 5 | 3388 | 3 | 3 | 2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+ | 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase | None | 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxy-D-gluconate dehydrogenase (ambiguous); 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase; 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase (ambiguous) | |
| 1.1.1.129 | L-threonate 3-dehydrogenase | True | 0 | 0 | 0 | 1 | L-threonate + NAD+ = 3-dehydro-L-erythronate + NADH + H+ | L-threonate:NAD+ 3-oxidoreductase | None | threonate dehydrogenase; L-threonic acid dehydrogenase | |
| 1.1.1.130 | 3-dehydro-L-gulonate 2-dehydrogenase | False | 41 | 1413 | 0 | 1 | 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+ | 3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase | None | 3-keto-L-gulonate dehydrogenase; 3-ketogulonate dehydrogenase; 3-keto-L-gulonate dehydrogenase; 3-ketogulonate dehydrogenase | |
| 1.1.1.131 | mannuronate reductase | False | 0 | 901 | 0 | 1 | D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+ | D-mannonate:NAD(P)+ 6-oxidoreductase | None | mannonate dehydrogenase; mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase; mannonate dehydrogenase; mannuronate reductase; mannonate dehydrogenase (NAD(P)+); D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming)) | |
| 1.1.1.132 | GDP-mannose 6-dehydrogenase | False | 6 | 1344 | 3 | 6 | GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ | GDP-D-mannose:NAD+ 6-oxidoreductase | None | guanosine diphosphomannose dehydrogenase; GDP-mannose dehydrogenase; guanosine diphosphomannose dehydrogenase; guanosine diphospho-D-mannose dehydrogenase | |
| 1.1.1.133 | dTDP-4-dehydrorhamnose reductase | False | 12 | 39374 | 8 | 14 | dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ | dTDP-beta-L-rhamnose:NADP+ 4-oxidoreductase | None | dTDP-4-keto-L-rhamnose reductase; dTDP-4-ketorhamnose reductase; TDP-4-keto-rhamnose reductase; thymidine diphospho-4-ketorhamnose reductase; dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase; dTDP-6-deoxy-beta-L-mannose:NADP+ 4-oxidoreductase | |
| 1.1.1.134 | dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP+) | True | 0 | 0 | 0 | 1 | dTDP-6-deoxy-beta-L-talose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ | dTDP-6-deoxy-beta-L-talose:NADP+ 4-oxidoreductase | None | thymidine diphospho-6-deoxy-L-talose dehydrogenase; TDP-6-deoxy-L-talose dehydrogenase; dTDP-6-deoxy-L-talose dehydrogenase (4-reductase); dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase | |
| 1.1.1.135 | GDP-6-deoxy-D-talose 4-dehydrogenase | False | 1 | 62 | 0 | 4 | GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ | GDP-6-deoxy-alpha-D-talose:NAD(P)+ 4-oxidoreductase | None | guanosine diphospho-6-deoxy-D-talose dehydrogenase; GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase | |
| 1.1.1.136 | UDP-N-acetylglucosamine 6-dehydrogenase | False | 1 | 1163 | 0 | 7 | UDP-N-acetyl-alpha-D-glucosamine + 2 NAD+ + H2O = UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + 2 NADH + 2 H+ | UDP-N-acetyl-alpha-D-glucosamine:NAD+ 6-oxidoreductase | None | uridine diphosphoacetylglucosamine dehydrogenase; UDP-acetylglucosamine dehydrogenase; UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase; UDP-GlcNAc dehydrogenase; WbpA; WbpO | |
| 1.1.1.137 | ribitol-5-phosphate 2-dehydrogenase | False | 0 | 17 | 0 | 2 | D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+ | D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase | None | ribitol 5-phosphate dehydrogenase | |
| 1.1.1.138 | mannitol 2-dehydrogenase (NADP+) | False | 6 | 19 | 4 | 28 | D-mannitol + NADP+ = D-fructose + NADPH + H+ | D-mannitol:NADP+ 2-oxidoreductase | None | mannitol 2-dehydrogenase (NADP+) | |
| 1.1.1.140 | sorbitol-6-phosphate 2-dehydrogenase | False | 2 | 1442 | 1 | 19 | D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+ | D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase | None | ketosephosphate reductase; ketosephosphate reductase; D-sorbitol 6-phosphate dehydrogenase; D-sorbitol-6-phosphate dehydrogenase; sorbitol-6-P-dehydrogenase; D-glucitol-6-phosphate dehydrogenase | |
| 1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) | False | 6 | 1872 | 4 | 13 | (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase | None | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I); PGDH; 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase; 15-OH-PGDH; 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostanoic dehydrogenase; NAD+-specific 15-hydroxyprostaglandin dehydrogenase; prostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NAD+); (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase | |
| 1.1.1.142 | D-pinitol dehydrogenase | True | 0 | 0 | 0 | 1 | 1D-3-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H+ | 1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase | None | 5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase | |
| 1.1.1.143 | sequoyitol dehydrogenase | True | 0 | 0 | 0 | 1 | 5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ | 5-O-methyl-myo-inositol:NAD+ oxidoreductase | None | D-pinitol dehydrogenase | |
| 1.1.1.144 | perillyl-alcohol dehydrogenase | False | 3 | 93 | 0 | 4 | perillyl alcohol + NAD+ = perillyl aldehyde + NADH + H+ | perillyl-alcohol:NAD+ oxidoreductase | None | perillyl alcohol dehydrogenase | |
| 1.1.1.145 | 3beta-hydroxy-Delta5-steroid dehydrogenase | False | 25 | 88 | 4 | 24 | a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid + NADH + H+ | 3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase | None | progesterone reductase; Delta5-3beta-hydroxysteroid dehydrogenase; 3beta-hydroxy-5-ene steroid dehydrogenase; 3beta-hydroxy steroid dehydrogenase/isomerase; 3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase; 3beta-hydroxy-Delta5-C27-steroid oxidoreductase; 3beta-hydroxy-5-ene-steroid oxidoreductase; steroid-Delta5-3beta-ol dehydrogenase; 3beta-HSDH; 5-ene-3-beta-hydroxysteroid dehydrogenase; 3beta-hydroxy-5-ene-steroid dehydrogenase | |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase | False | 15 | 1041 | 52 | 21 | an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ | 11beta-hydroxysteroid:NADP+ 11-oxidoreductase | None | corticosteroid 11beta-dehydrogenase; beta-hydroxysteroid dehydrogenase; 11beta-hydroxy steroid dehydrogenase; corticosteroid 11-reductase; dehydrogenase, 11beta-hydroxy steroid | |
| 1.1.1.147 | 16alpha-hydroxysteroid dehydrogenase | True | 0 | 0 | 0 | 2 | a 16alpha-hydroxysteroid + NAD(P)+ = a 16-oxosteroid + NAD(P)H + H+ | 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase | None | 16alpha-hydroxy steroid dehydrogenase | |
| 1.1.1.148 | estradiol 17alpha-dehydrogenase | True | 0 | 0 | 0 | 5 | estradiol-17alpha + NAD(P)+ = estrone + NAD(P)H + H+ | 17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase | None | 17alpha-estradiol dehydrogenase; 17alpha-hydroxy steroid dehydrogenase; 17alpha-hydroxy steroid oxidoreductase; 17alpha-hydroxysteroid oxidoreductase; estradiol 17alpha-oxidoreductase | |
| 1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase | False | 8 | 69 | 2 | 13 | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ | 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase | None | 20alpha-hydroxy steroid dehydrogenase; 20alpha-HSD; 20alpha-HSDH | |
| 1.1.1.150 | 21-hydroxysteroid dehydrogenase (NAD+) | True | 0 | 0 | 0 | 5 | pregnan-21-ol + NAD+ = pregnan-21-al + NADH + H+ | 21-hydroxysteroid:NAD+ 21-oxidoreductase | None | 21-hydroxysteroid dehydrogenase (NAD+) | |
| 1.1.1.151 | 21-hydroxysteroid dehydrogenase (NADP+) | True | 0 | 0 | 0 | 1 | pregnan-21-ol + NADP+ = pregnan-21-al + NADPH + H+ | 21-hydroxysteroid:NADP+ 21-oxidoreductase | None | 21-hydroxy steroid dehydrogenase; 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase; 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate); NADP+-21-hydroxysteroid dehydrogenase; 21-hydroxysteroid dehydrogenase (NADP+) | |
| 1.1.1.152 | 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase | False | 0 | 8 | 0 | 1 | 3alpha-hydroxy-5beta-androstane-17-one + NAD+ = 5beta-androstane-3,17-dione + NADH + H+ | 3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase | None | etiocholanolone 3alpha-dehydrogenase; etiocholanolone 3alpha-dehydrogenase; 3alpha-hydroxy-5beta-steroid dehydrogenase | |
| 1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) | False | 8 | 1176 | 18 | 18 | (1) L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+;;(2) L-erythro-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ | L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase | None | SR | |
| 1.1.1.154 | ureidoglycolate dehydrogenase | False | 0 | 918 | 5 | 2 | (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+ | (S)-ureidoglycolate:NAD(P)+ oxidoreductase | None | None | |
| 1.1.1.156 | glycerol 2-dehydrogenase (NADP+) | False | 2 | 18 | 0 | 9 | glycerol + NADP+ = glycerone + NADPH + H+ | glycerol:NADP+ 2-oxidoreductase (glycerone-forming) | None | dihydroxyacetone reductase; dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase; dihydroxyacetone reductase (NADPH); DHA oxidoreductase; glycerol 2-dehydrogenase (NADP+) | |
| 1.1.1.157 | 3-hydroxybutyryl-CoA dehydrogenase | False | 9 | 15069 | 8 | 6 | (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+ | (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase | None | beta-hydroxybutyryl coenzyme A dehydrogenase; L(+)-3-hydroxybutyryl-CoA dehydrogenase; BHBD; dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate); L-(+)-3-hydroxybutyryl-CoA dehydrogenase; beta-hydroxybutyryl-CoA dehydrogenase | |
| 1.1.1.159 | 7alpha-hydroxysteroid dehydrogenase | False | 7 | 786 | 14 | 13 | cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+ | 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase | None | 7alpha-hydroxy steroid dehydrogenase; 7alpha-HSDH | |
| 1.1.1.160 | dihydrobunolol dehydrogenase | True | 0 | 0 | 0 | 1 | (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H+ | (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase | None | bunolol reductase | |
| 1.1.1.162 | erythrulose reductase | False | 1 | 6 | 0 | 2 | D-threitol + NADP+ = D-erythrulose + NADPH + H+ | D-threitol:NADP+ oxidoreductase | None | D-erythrulose reductase; erythritol:NADP+ oxidoreductase | |
| 1.1.1.163 | cyclopentanol dehydrogenase | False | 2 | 886 | 0 | 2 | cyclopentanol + NAD+ = cyclopentanone + NADH + H+ | cyclopentanol:NAD+ oxidoreductase | None | None | |
| 1.1.1.164 | hexadecanol dehydrogenase | True | 0 | 0 | 0 | 4 | hexadecanol + NAD+ = hexadecanal + NADH + H+ | hexadecanol:NAD+ oxidoreductase | None | None | |
| 1.1.1.165 | 2-alkyn-1-ol dehydrogenase | True | 0 | 0 | 0 | 1 | 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+ | 2-butyne-1,4-diol:NAD+ 1-oxidoreductase | None | None | |
| 1.1.1.166 | hydroxycyclohexanecarboxylate dehydrogenase | False | 0 | 8 | 0 | 1 | (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H+ | (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase | None | dihydroxycyclohexanecarboxylate dehydrogenase; (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD+ oxidoreductase | |
| 1.1.1.167 | hydroxymalonate dehydrogenase | True | 0 | 0 | 0 | 1 | hydroxymalonate + NAD+ = oxomalonate + NADH + H+ | hydroxymalonate:NAD+ oxidoreductase | None | None | |
| 1.1.1.168 | 2-dehydropantolactone reductase (Re-specific) | True | 0 | 0 | 0 | 6 | (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ | (R)-pantolactone:NADP+ oxidoreductase (Re-specific) | None | 2-oxopantoyl lactone reductase; ketopantoyl lactone reductase; 2-ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase (A-specific); (R)-pantolactone:NADP+ oxidoreductase (A-specific); 2-dehydropantolactone reductase (A-specific) | |
| 1.1.1.169 | 2-dehydropantoate 2-reductase | False | 32 | 39677 | 21 | 13 | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ | (R)-pantoate:NADP+ 2-oxidoreductase | None | 2-oxopantoate reductase; 2-ketopantoate reductase; 2-ketopantoic acid reductase; ketopantoate reductase; ketopantoic acid reductase | |
| 1.1.1.170 | 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) | False | 9 | 121 | 2 | 5 | a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H | 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating) | None | 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating); 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase; sterol 4alpha-carboxylic decarboxylase; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous); ERG26 (gene name); NSDHL (gene name) | |
| 1.1.1.172 | 2-oxoadipate reductase | True | 0 | 0 | 0 | 2 | 2-hydroxyadipate + NAD+ = 2-oxoadipate + NADH + H+ | 2-hydroxyadipate:NAD+ 2-oxidoreductase | None | 2-ketoadipate reductase; alpha-ketoadipate reductase; 2-ketoadipate reductase | |
| 1.1.1.173 | L-rhamnose 1-dehydrogenase | False | 1 | 42 | 0 | 4 | L-rhamnofuranose + NAD+ = L-rhamno-1,4-lactone + NADH + H+ | L-rhamnofuranose:NAD+ 1-oxidoreductase | None | None | |
| 1.1.1.174 | cyclohexane-1,2-diol dehydrogenase | True | 0 | 0 | 0 | 2 | trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH + H+ | trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase | None | None | |
| 1.1.1.175 | D-xylose 1-dehydrogenase | False | 2 | 62 | 0 | 5 | D-xylose + NAD+ = D-xylonolactone + NADH + H+ | D-xylose:NAD+ 1-oxidoreductase | None | NAD+-D-xylose dehydrogenase; D-xylose dehydrogenase; (NAD+)-linked D-xylose dehydrogenase | |
| 1.1.1.176 | 12alpha-hydroxysteroid dehydrogenase | False | 1 | 0 | 0 | 8 | cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+ | 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase | None | 12alpha-hydroxy steroid dehydrogenase; NAD+-dependent 12alpha-hydroxysteroid dehydrogenase; NADP+-12alpha-hydroxysteroid dehydrogenase | |
| 1.1.1.177 | glycerol-3-phosphate 1-dehydrogenase (NADP+) | True | 0 | 0 | 0 | 3 | sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+ | sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase | None | glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; L-glycerol 3-phosphate:NADP+ oxidoreductase; glycerin-3-phosphate dehydrogenase; NADPH-dependent glycerin-3-phosphate dehydrogenase; NADP-specific glycerol 3-phosphate 1-dehydrogenase | |
| 1.1.1.178 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | False | 4 | 131 | 2 | 5 | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase | None | 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase; 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase; 2-methyl-3-hydroxy-butyryl CoA dehydrogenase | |
| 1.1.1.179 | D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) | False | 16 | 6100 | 0 | 13 | D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+ | D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,5-lactone-forming) | None | D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase (ambiguous); D-xylose-NADP dehydrogenase (ambiguous); D-xylose:NADP+ oxidoreductase (ambiguous); D-xylose 1-dehydrogenase (NADP) (ambiguous) | |
| 1.1.1.181 | cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase | False | 3 | 8 | 0 | 2 | cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ | cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase | None | 3beta-hydroxy-Delta5-C27-steroid oxidoreductase (ambiguous) | |
| 1.1.1.183 | geraniol dehydrogenase (NADP+) | False | 1 | 17 | 0 | 12 | geraniol + NADP+ = geranial + NADPH + H+ | geraniol:NADP+ oxidoreductase | None | None | |
| 1.1.1.184 | carbonyl reductase (NADPH) | False | 22 | 2393 | 15 | 38 | R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ | secondary-alcohol:NADP+ oxidoreductase | None | aldehyde reductase 1; prostaglandin 9-ketoreductase; xenobiotic ketone reductase; NADPH-dependent carbonyl reductase; ALR3; carbonyl reductase; nonspecific NADPH-dependent carbonyl reductase; carbonyl reductase (NADPH2) | |
| 1.1.1.185 | L-glycol dehydrogenase | True | 0 | 0 | 0 | 2 | an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ | L-glycol:NAD(P)+ oxidoreductase | None | glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase; L-(+)-glycol:NAD(P)+ oxidoreductase; L-glycol:NAD(P)+ dehydrogenase | |
| 1.1.1.186 | dTDP-galactose 6-dehydrogenase | True | 0 | 0 | 0 | 1 | dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+ | dTDP-D-galactose:NADP+ 6-oxidoreductase | None | thymidine-diphosphate-galactose dehydrogenase | |
| 1.1.1.187 | GDP-4-dehydro-D-rhamnose reductase | False | 0 | 4 | 0 | 4 | (1) GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+;;(2) GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ | GDP-4-dehydro-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase | None | GDP-4-keto-6-deoxy-D-mannose reductase; GDP-4-keto-D-rhamnose reductase; guanosine diphosphate-4-keto-D-rhamnose reductase; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase; GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase | |
| 1.1.1.188 | prostaglandin-F synthase | False | 4 | 79 | 5 | 15 | (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ | (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase | None | prostaglandin-D2 11-reductase; reductase, 15-hydroxy-11-oxoprostaglandin; PGD2 11-ketoreductase; PGF2alpha synthetase; prostaglandin 11-ketoreductase; prostaglandin D2-ketoreductase; prostaglandin F synthase; prostaglandin F synthetase; synthetase, prostaglandin F2alpha; PGF synthetase; NADPH-dependent prostaglandin D2 11-keto reductase; prostaglandin 11-keto reductase | |
| 1.1.1.189 | prostaglandin-E2 9-reductase | False | 9 | 77 | 2 | 9 | (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase | None | PGE2-9-OR; reductase, 15-hydroxy-9-oxoprostaglandin; 9-keto-prostaglandin E2 reductase; 9-ketoprostaglandin reductase; PGE-9-ketoreductase; PGE2 9-oxoreductase; PGE2-9-ketoreductase; prostaglandin 9-ketoreductase; prostaglandin E 9-ketoreductase; prostaglandin E2-9-oxoreductase | |
| 1.1.1.190 | indole-3-acetaldehyde reductase (NADH) | False | 1 | 2 | 0 | 4 | (indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+ | (indol-3-yl)ethanol:NAD+ oxidoreductase | None | indoleacetaldehyde reductase; indole-3-acetaldehyde reductase (NADH); indole-3-ethanol:NAD+ oxidoreductase | |
| 1.1.1.191 | indole-3-acetaldehyde reductase (NADPH) | False | 1 | 4 | 0 | 7 | (indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+ | (indol-3-yl)ethanol:NADP+ oxidoreductase | None | indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase; indole-3-acetaldehyde reductase (NADPH); indole-3-ethanol:NADP+ oxidoreductase | |
| 1.1.1.192 | long-chain-alcohol dehydrogenase | False | 2 | 234 | 0 | 10 | a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH + 2 H+ | long-chain-alcohol:NAD+ oxidoreductase | None | long-chain alcohol dehydrogenase; fatty alcohol oxidoreductase | |
| 1.1.1.193 | 5-amino-6-(5-phosphoribosylamino)uracil reductase | False | 18 | 34061 | 2 | 5 | 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+ | 5-amino-6-(5-phospho-D-ribitylamino)uracil:NADP+ 1'-oxidoreductase | None | aminodioxyphosphoribosylaminopyrimidine reductase | |
| 1.1.1.194 | coniferyl-alcohol dehydrogenase | False | 1 | 212 | 0 | 15 | coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH + H+ | coniferyl-alcohol:NADP+ oxidoreductase | None | CAD (ambiguous) | |
| 1.1.1.195 | cinnamyl-alcohol dehydrogenase | False | 42 | 1744 | 11 | 110 | cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+ | cinnamyl-alcohol:NADP+ oxidoreductase | None | cinnamyl alcohol dehydrogenase; CAD (ambiguous) | |
| 1.1.1.196 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) | False | 8 | 48 | 0 | 2 | (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+ | (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase | None | prostaglandin-D 15-dehydrogenase (NADP+); dehydrogenase, prostaglandin D2; NADP+-PGD2 dehydrogenase; dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate); 15-hydroxy PGD2 dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP+); NADP+-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin D2 dehydrogenase; NADP+-linked 15-hydroxyprostaglandin dehydrogenase; NADP+-specific 15-hydroxyprostaglandin dehydrogenase; NADP+-linked prostaglandin D2 dehydrogenase; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) | |
| 1.1.1.197 | 15-hydroxyprostaglandin dehydrogenase (NADP+) | False | 8 | 72 | 0 | 6 | (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ | (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase | None | NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP) | |
| 1.1.1.198 | (+)-borneol dehydrogenase | False | 2 | 13 | 0 | 8 | (+)-borneol + NAD+ = (+)-camphor + NADH + H+ | (+)-borneol:NAD+ oxidoreductase | None | bicyclic monoterpenol dehydrogenase | |
| 1.1.1.199 | (S)-usnate reductase | True | 0 | 0 | 0 | 1 | (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methyl-2,4-cyclohexadien-1-one + NAD+ = (S)-usnate + NADH + H+ | reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming) | None | L-usnic acid dehydrogenase | |
| 1.1.1.200 | aldose-6-phosphate reductase (NADPH) | False | 1 | 8 | 1 | 8 | D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH + H+ | D-aldose-6-phosphate:NADP+ 1-oxidoreductase | None | aldose 6-phosphate reductase; NADP+-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP+ 1-oxidoreductase; aldose-6-phosphate reductase (NADPH) | |
| 1.1.1.201 | 7beta-hydroxysteroid dehydrogenase (NADP+) | False | 13 | 990 | 1 | 8 | a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+ | 7beta-hydroxysteroid:NADP+ 7-oxidoreductase | None | NADP+-dependent 7beta-hydroxysteroid dehydrogenase; 7beta-hydroxysteroid dehydrogenase (NADP+) | |
| 1.1.1.202 | 1,3-propanediol dehydrogenase | False | 2 | 928 | 1 | 13 | propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+ | propane-1,3-diol:NAD+ 1-oxidoreductase | None | 3-hydroxypropionaldehyde reductase; 1,3-PD:NAD+ oxidoreductase; 1,3-propanediol:NAD+ oxidoreductase; 1,3-propanediol dehydrogenase | |
| 1.1.1.203 | uronate dehydrogenase | False | 3 | 421 | 3 | 16 | (1) beta-D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+;;(2) beta-D-glucuronate + NAD+ = D-glucaro-1,5-lactone + NADH + H+ | uronate:NAD+ 1-oxidoreductase | None | uronate:NAD-oxidoreductase; uronic acid dehydrogenase | |
| 1.1.1.205 | IMP dehydrogenase | False | 89 | 44843 | 160 | 65 | IMP + NAD+ + H2O = XMP + NADH + H+ | IMP:NAD+ oxidoreductase | None | inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase | |
| 1.1.1.206 | tropinone reductase I | False | 2 | 118 | 0 | 29 | tropine + NADP+ = tropinone + NADPH + H+ | tropine:NADP+ 3alpha-oxidoreductase | None | tropine dehydrogenase; tropinone reductase (ambiguous); TR-I | |
| 1.1.1.207 | (-)-menthol dehydrogenase | False | 0 | 6 | 0 | 2 | (-)-menthol + NADP+ = (-)-menthone + NADPH + H+ | (-)-menthol:NADP+ oxidoreductase | None | monoterpenoid dehydrogenase | |
| 1.1.1.208 | (+)-neomenthol dehydrogenase | False | 2 | 30 | 2 | 5 | (+)-neomenthol + NADP+ = (-)-menthone + NADPH + H+ | (+)-neomenthol:NADP+ oxidoreductase | None | monoterpenoid dehydrogenase | |
| 1.1.1.209 | 3(or 17)alpha-hydroxysteroid dehydrogenase | False | 24 | 1 | 2 | 4 | androsterone + NAD(P)+ = 5alpha-androstane-3,17-dione + NAD(P)H + H+ | 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase | None | 3(17)alpha-hydroxysteroid dehydrogenase | |
| 1.1.1.210 | 3beta(or 20alpha)-hydroxysteroid dehydrogenase | False | 21 | 17 | 0 | 3 | 5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+ | 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase | None | progesterone reductase; dehydrogenase, 3beta,20alpha-hydroxy steroid; 3beta,20alpha-hydroxysteroid oxidoreductase | |
| 1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase | False | 4 | 27 | 0 | 5 | a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+ | long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase | None | beta-hydroxyacyl-CoA dehydrogenase; long-chain 3-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase; LCHAD | |
| 1.1.1.212 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) | False | 1 | 1 | 0 | 1 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NAD+ = a 3-oxoacyl-[acyl-carrier protein] + NADH + H+ | (3R)-3-hydroxyacyl-[acyl-carrier protein]:NAD+ oxidoreductase | None | 3-oxoacyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide) reductase; 3-oxoacyl-[acyl-carrier-protein] reductase (NADH); (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NAD+ oxidoreductase | |
| 1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) | False | 0 | 4 | 16 | 8 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ | 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific) | None | 3alpha-hydroxysteroid dehydrogenase; 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific); 3alpha-hydroxysteroid 3-dehydrogenase (A-specific) | |
| 1.1.1.214 | 2-dehydropantolactone reductase (Si-specific) | False | 0 | 0 | 2 | 5 | (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ | (R)-pantolactone:NADP+ oxidoreductase (Si-specific) | None | 2-oxopantoyl lactone reductase; 2-ketopantoyl lactone reductase; ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase (B-specific); (R)-pantolactone:NADP+ oxidoreductase (B-specific); 2-dehydropantolactone reductase (B-specific) | |
| 1.1.1.215 | gluconate 2-dehydrogenase | False | 4 | 540 | 0 | 16 | D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+ | D-gluconate:NADP+ oxidoreductase | None | 2-keto-D-gluconate reductase; 2-ketogluconate reductase | |
| 1.1.1.216 | farnesol dehydrogenase (NADP+) | False | 3 | 11 | 0 | 6 | (2E,6E)-farnesol + NADP+ = (2E,6E)-farnesal + NADPH + H+ | (2E,6E)-farnesol:NADP+ 1-oxidoreductase | None | NADP+-farnesol dehydrogenase; farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase | |
| 1.1.1.217 | benzyl-2-methyl-hydroxybutyrate dehydrogenase | True | 0 | 0 | 0 | 1 | benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + NADPH + H+ | benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase | None | benzyl 2-methyl-3-hydroxybutyrate dehydrogenase | |
| 1.1.1.218 | morphine 6-dehydrogenase | False | 3 | 159 | 2 | 6 | morphine + NAD(P)+ = morphinone + NAD(P)H + H+ | morphine:NAD(P)+ 6-oxidoreductase | None | naloxone reductase | |
| 1.1.1.219 | dihydroflavonol 4-reductase | False | 14 | 1619 | 5 | 50 | a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ | (2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase | None | dihydrokaempferol 4-reductase; dihydromyricetin reductase; NADPH-dihydromyricetin reductase; dihydroquercetin reductase; DFR (gene name); cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase; dihydroflavanol 4-reductase (incorrect) | |
| 1.1.1.220 | 6-pyruvoyltetrahydropterin 2'-reductase | True | 0 | 0 | 0 | 3 | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+ | 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase | None | 6-pyruvoyltetrahydropterin reductase; 6PPH4(2'-oxo) reductase; 6-pyruvoyl tetrahydropterin (2'-oxo)reductase; 6-pyruvoyl-tetrahydropterin 2'-reductase; pyruvoyl-tetrahydropterin reductase | |
| 1.1.1.221 | vomifoliol dehydrogenase | True | 0 | 0 | 0 | 1 | (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + NADH + H+ | (6S,9R)-6-hydroxy-3-oxo-alpha-ionol:NAD+ oxidoreductase | None | vomifoliol 4'-dehydrogenase; vomifoliol:NAD+ 4'-oxidoreductase | |
| 1.1.1.223 | isopiperitenol dehydrogenase | False | 1 | 0 | 0 | 2 | (-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+ | (-)-trans-isopiperitenol:NAD+ oxidoreductase | None | None | |
| 1.1.1.224 | mannose-6-phosphate 6-reductase | False | 0 | 10 | 0 | 6 | D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH + H+ | D-mannitol-1-phosphate:NADP+ 6-oxidoreductase | None | NADPH-dependent mannose 6-phosphate reductase; mannose-6-phosphate reductase; 6-phosphomannose reductase; NADP+-dependent mannose-6-P:mannitol-1-P oxidoreductase; NADPH-dependent M6P reductase; NADPH-mannose-6-P reductase | |
| 1.1.1.225 | chlordecone reductase | False | 3 | 3 | 1 | 3 | chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ | chlordecone-alcohol:NADP+ 2-oxidoreductase | None | CDR | |
| 1.1.1.226 | trans-4-hydroxycyclohexanecarboxylate dehydrogenase | True | 0 | 0 | 0 | 2 | trans-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+ | trans-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase | None | 4-hydroxycyclohexanecarboxylate dehydrogenase (ambiguous); chcB1 (gene name) | |
| 1.1.1.227 | (-)-borneol dehydrogenase | True | 0 | 0 | 0 | 5 | (-)-borneol + NAD+ = (-)-camphor + NADH + H+ | (-)-borneol:NAD+ oxidoreductase | None | None | |
| 1.1.1.228 | (+)-sabinol dehydrogenase | True | 0 | 0 | 0 | 2 | (+)-cis-sabinol + NAD+ = (+)-sabinone + NADH + H+ | (+)-cis-sabinol:NAD+ oxidoreductase | None | (+)-cis-sabinol dehydrogenase | |
| 1.1.1.229 | diethyl 2-methyl-3-oxosuccinate reductase | True | 0 | 0 | 0 | 1 | diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + NADPH + H+ | diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase | None | None | |
| 1.1.1.230 | 3alpha-hydroxyglycyrrhetinate dehydrogenase | True | 0 | 0 | 0 | 2 | 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + NADPH + H+ | 3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase | None | None | |
| 1.1.1.231 | 15-hydroxyprostaglandin-I dehydrogenase (NADP+) | True | 0 | 0 | 0 | 4 | (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+ | (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase | None | prostacyclin dehydrogenase; PG I2 dehydrogenase; prostacyclin dehydrogenase; NADP+-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase; NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin-I dehydrogenase (NADP+) | |
| 1.1.1.232 | 15-hydroxyicosatetraenoate dehydrogenase | False | 6 | 1854 | 0 | 1 | (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H+ | (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase | None | 15-hydroxyeicosatetraenoate dehydrogenase | |
| 1.1.1.233 | N-acylmannosamine 1-dehydrogenase | False | 1 | 10 | 3 | 1 | N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + NADH + H+ | N-acyl-D-mannosamine:NAD+ 1-oxidoreductase | None | N-acylmannosamine dehydrogenase; N-acetyl-D-mannosamine dehydrogenase; N-acyl-D-mannosamine dehydrogenase; N-acylmannosamine dehydrogenase | |
| 1.1.1.234 | flavanone 4-reductase | False | 13 | 1045 | 1 | 7 | (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH + H+ | (2S)-flavan-4-ol:NADP+ 4-oxidoreductase | None | None | |
| 1.1.1.235 | 8-oxocoformycin reductase | False | 0 | 2 | 0 | 1 | coformycin + NADP+ = 8-oxocoformycin + NADPH + H+ | coformycin:NADP+ 8-oxidoreductase | None | 8-ketodeoxycoformycin reductase | |
| 1.1.1.236 | tropinone reductase II | False | 3 | 14 | 6 | 23 | pseudotropine + NADP+ = tropinone + NADPH + H+ | pseudotropine:NADP+ 3-oxidoreductase | None | tropinone (psi-tropine-forming) reductase; pseudotropine forming tropinone reductase; tropinone reductase (ambiguous); TR-II | |
| 1.1.1.237 | hydroxyphenylpyruvate reductase | False | 3 | 22 | 2 | 8 | (1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+;;(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+;; | (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase | None | HPPR | |
| 1.1.1.238 | 12beta-hydroxysteroid dehydrogenase | True | 0 | 0 | 0 | 1 | 3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+ | 12beta-hydroxysteroid:NADP+ 12-oxidoreductase | None | 12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase | |
| 1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) | False | 19 | 22 | 0 | 12 | testosterone + NAD+ = androstenedione + NADH + H+ | 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase | None | 3alpha,17beta-hydroxy steroid dehydrogenase; 3alpha(17beta)-HSD; 17-ketoreductase (ambiguous); 17beta-HSD (ambiguous); HSD17B6 (gene name); HSD17B8 (gene name) | |
| 1.1.1.240 | N-acetylhexosamine 1-dehydrogenase | True | 0 | 0 | 0 | 1 | N-acetyl-alpha-D-glucosamine + NAD+ = N-acetyl-D-glucosaminate + NADH + H+ | N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase | None | N-acetylhexosamine dehydrogenase; N-acetyl-D-hexosamine dehydrogenase | |
| 1.1.1.241 | 6-endo-hydroxycineole dehydrogenase | True | 0 | 0 | 0 | 1 | 6-endo-hydroxycineole + NAD+ = 6-oxocineole + NADH + H+ | 6-endo-hydroxycineole:NAD+ 6-oxidoreductase | None | None | |
| 1.1.1.243 | carveol dehydrogenase | False | 2 | 101 | 0 | 3 | (-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+ | (-)-trans-carveol:NADP+ oxidoreductase | None | (-)-trans-carveol dehydrogenase | |
| 1.1.1.244 | methanol dehydrogenase | False | 1 | 532 | 0 | 10 | methanol + NAD+ = formaldehyde + NADH + H+ | methanol:NAD+ oxidoreductase | None | None | |
| 1.1.1.245 | cyclohexanol dehydrogenase | False | 4 | 6 | 0 | 7 | cyclohexanol + NAD+ = cyclohexanone + NADH + H+ | cyclohexanol:NAD+ oxidoreductase | None | None | |
| 1.1.1.247 | codeinone reductase (NADPH) | False | 5 | 5 | 1 | 4 | codeine + NADP+ = codeinone + NADPH + H+ | codeine:NADP+ oxidoreductase | None | None | |
| 1.1.1.248 | salutaridine reductase (NADPH) | False | 2 | 12 | 1 | 5 | salutaridinol + NADP+ = salutaridine + NADPH + H+ | salutaridinol:NADP+ 7-oxidoreductase | None | None | |
| 1.1.1.250 | D-arabinitol 2-dehydrogenase | False | 4 | 17 | 0 | 3 | D-arabinitol + NAD+ = D-ribulose + NADH + H+ | D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming) | None | D-arabinitol 2-dehydrogenase (ribulose-forming) | |
| 1.1.1.251 | galactitol-1-phosphate 5-dehydrogenase | False | 2 | 692 | 4 | 2 | galactitol 1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+ | galactitol-1-phosphate:NAD+ oxidoreductase | None | gatD (gene name) | |
| 1.1.1.252 | tetrahydroxynaphthalene reductase | False | 3 | 36 | 3 | 8 | scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ | scytalone:NADP+ Delta5-oxidoreductase | None | None | |
| 1.1.1.254 | (S)-carnitine 3-dehydrogenase | True | 0 | 0 | 0 | 2 | (S)-carnitine + NAD+ = 3-dehydrocarnitine + NADH + H+ | (S)-carnitine:NAD+ oxidoreductase | None | None | |
| 1.1.1.255 | mannitol dehydrogenase | False | 7 | 78 | 0 | 2 | D-mannitol + NAD+ = D-mannose + NADH + H+ | mannitol:NAD+ 1-oxidoreductase | None | MTD; NAD+-dependent mannitol dehydrogenase | |
| 1.1.1.256 | fluoren-9-ol dehydrogenase | False | 1 | 0 | 0 | 2 | fluoren-9-ol + NAD(P)+ = fluoren-9-one + NAD(P)H + H+ | fluoren-9-ol:NAD(P)+ oxidoreductase | None | None | |
| 1.1.1.257 | 4-(hydroxymethyl)benzenesulfonate dehydrogenase | False | 2 | 16 | 0 | 1 | 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + NADH + H+ | 4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase | None | None | |
| 1.1.1.258 | 6-hydroxyhexanoate dehydrogenase | False | 0 | 1 | 0 | 2 | 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+ | 6-hydroxyhexanoate:NAD+ oxidoreductase | None | None | |
| 1.1.1.259 | 3-hydroxypimeloyl-CoA dehydrogenase | True | 0 | 0 | 0 | 2 | 3-hydroxypimeloyl-CoA + NAD+ = 3-oxopimeloyl-CoA + NADH + H+ | 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase | None | None | |
| 1.1.1.260 | sulcatone reductase | True | 0 | 0 | 0 | 8 | sulcatol + NAD+ = sulcatone + NADH + H+ | sulcatol:NAD+ oxidoreductase | None | None | |
| 1.1.1.261 | sn-glycerol-1-phosphate dehydrogenase | False | 68 | 2530 | 4 | 12 | sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ | sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase | None | glycerol-1-phosphate dehydrogenase [NAD(P)+]; sn-glycerol-1-phosphate:NAD+ oxidoreductase; G-1-P dehydrogenase; Gro1PDH; AraM | |
| 1.1.1.262 | 4-hydroxythreonine-4-phosphate dehydrogenase | False | 138 | 21312 | 12 | 1 | 4-phosphooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ | 4-phosphooxy-L-threonine:NAD+ 3-oxidoreductase (decarboxylating) | None | NAD+-dependent threonine 4-phosphate dehydrogenase; L-threonine 4-phosphate dehydrogenase; 4-(phosphohydroxy)-L-threonine dehydrogenase; PdxA; 4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase; 4-phosphooxy-L-threonine:NAD+ oxidoreductase | |
| 1.1.1.263 | 1,5-anhydro-D-fructose reductase | False | 5 | 287 | 1 | 7 | 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ | 1,5-anhydro-D-glucitol:NADP+ oxidoreductase | None | None | |
| 1.1.1.264 | L-idonate 5-dehydrogenase | False | 1 | 602 | 1 | 15 | L-idonate + NAD(P)+ = 5-dehydro-D-gluconate + NAD(P)H + H+ | L-idonate:NAD(P)+ oxidoreductase | None | None | |
| 1.1.1.265 | 3-methylbutanal reductase | False | 1 | 0 | 0 | 3 | 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+ | 3-methylbutanol:NAD(P)+ oxidoreductase | None | None | |
| 1.1.1.266 | dTDP-4-dehydro-6-deoxyglucose reductase | False | 1 | 63 | 0 | 2 | dTDP-alpha-D-fucopyranose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NAD(P)H + H+ | dTDP-alpha-D-fucopyranose:NAD(P)+ oxidoreductase | None | dTDP-4-keto-6-deoxyglucose reductase; dTDP-D-fucose:NADP+ oxidoreductase; Fcf1; dTDP-6-deoxy-D-xylo-hex-4-ulopyranose reductase | |
| 1.1.1.267 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | False | 446 | 36434 | 74 | 42 | 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | 2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing) | None | DXP-reductoisomerase; 1-deoxy-D-xylulose-5-phosphate isomeroreductase; 2-C-methyl-D-erythritol 4-phosphate (MEP) synthase | |
| 1.3.1.88 | tRNA-dihydrouridine16/17 synthase [NAD(P)+] | False | 5 | 3774 | 0 | 1 | (1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ = uracil16 in tRNA + NAD(P)H + H+;;(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ = uracil17 in tRNA + NAD(P)H + H+ | tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase | None | Dus1p; tRNA-dihydrouridine synthase 1 | |
| 1.1.1.268 | 2-(R)-hydroxypropyl-CoM dehydrogenase | False | 1 | 446 | 1 | 2 | 2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ | 2-{[(2R)-2-hydroxypropyl]sulfanyl}ethane-1-sulfonate:NAD+ oxidoreductase | None | 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase; 2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase | |
| 1.1.1.269 | 2-(S)-hydroxypropyl-CoM dehydrogenase | False | 2 | 183 | 0 | 2 | (2S)-2-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ | 2-{[(2S)-2-hydroxypropyl]sulfanyl}ethanesulfonate:NAD+ oxidoreductase | None | 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase; 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase | |
| 1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase | False | 26 | 677 | 0 | 11 | a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ | 3beta-hydroxysteroid:NADP+ 3-oxidoreductase | None | 3-keto-steroid reductase; 3-KSR; HSD17B7 (gene name); ERG27 (gene name) | |
| 1.1.1.271 | GDP-L-fucose synthase | False | 14 | 18994 | 11 | 12 | GDP-beta-L-fucose + NADP+ = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+ | GDP-beta-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) | None | GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) | |
| 1.1.1.272 | D-2-hydroxyacid dehydrogenase (NADP+) | False | 2 | 507 | 1 | 2 | an (R)-2-hydroxycarboxylate + NADP+ = a 2-oxocarboxylate + NADPH + H+ | (R)-2-hydroxycarboxylate:NADP+ oxidoreductase | None | ddh (gene name) | |
| 1.1.1.273 | vellosimine dehydrogenase | True | 0 | 0 | 0 | 6 | 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+ | 10-deoxysarpagine:NADP+ oxidoreductase | None | None | |
| 1.1.1.274 | 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming) | False | 2 | 2161 | 2 | 4 | 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+ | 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-D-gluconate-forming) | None | 2,5-diketo-D-gluconate reductase (ambiguous) | |
| 1.1.1.343 | phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) | False | 3 | 1050 | 2 | 17 | 6-phospho-D-gluconate + NAD+ = D-ribulose 5-phosphate + CO2 + NADH + H+ | 6-phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) | None | 6-PGDH (ambiguous); gntZ (gene name); GNDl | |
| 1.1.1.275 | (+)-trans-carveol dehydrogenase | False | 0 | 158 | 5 | 3 | (+)-trans-carveol + NAD+ = (+)-(S)-carvone + NADH + H+ | (+)-trans-carveol:NAD+ oxidoreductase | None | carveol dehydrogenase | |
| 1.1.1.276 | serine 3-dehydrogenase (NADP+) | False | 2 | 901 | 6 | 3 | L-serine + NADP+ = 2-aminoacetaldehyde + CO2 + NADPH + H+ (overall reaction);; (1a) L-serine + NADP+ = 2-aminomalonate semialdehyde + NADPH + H+;; (1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) | L-serine:NADP+ 3-oxidoreductase | None | serine 3-dehydrogenase | |
| 1.1.1.277 | 3beta-hydroxy-5beta-steroid dehydrogenase | True | 0 | 0 | 0 | 2 | 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+ | 3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase | None | 3beta-hydroxysteroid 5beta-oxidoreductase; 3beta-hydroxysteroid 5beta-progesterone oxidoreductase | |
| 1.1.1.278 | 3beta-hydroxy-5alpha-steroid dehydrogenase | True | 0 | 0 | 0 | 6 | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnan-3,20-dione + NADPH + H+ | 3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase | None | None | |
| 1.1.1.279 | (R)-3-hydroxyacid-ester dehydrogenase | True | 0 | 0 | 0 | 1 | ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ | ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase | None | 3-oxo ester (R)-reductase | |
| 1.1.1.280 | (S)-3-hydroxyacid-ester dehydrogenase | True | 0 | 0 | 0 | 2 | ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ | ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase | None | 3-oxo ester (S)-reductase | |
| 1.1.1.281 | GDP-4-dehydro-6-deoxy-D-mannose reductase | False | 2 | 394 | 0 | 2 | GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ | GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase | None | GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous]; GDP-6-deoxy-D-lyxo-4-hexulose reductase; Rmd; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming); GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) | |
| 1.1.1.282 | quinate/shikimate dehydrogenase [NAD(P)+] | False | 37 | 622 | 1 | 22 | (1) L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+;;(2) shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+ | L-quinate:NAD(P)+ 3-oxidoreductase | None | YdiB; quinate/shikimate dehydrogenase (ambiguous) | |
| 1.1.1.283 | methylglyoxal reductase (NADPH) | False | 3 | 311 | 2 | 22 | (S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+ | (S)-lactaldehyde:NADP+ oxidoreductase | None | lactaldehyde dehydrogenase (NADP+); GRE2 (gene name); methylglyoxal reductase (NADPH-dependent); lactaldehyde:NADP+ oxidoreductase | |
| 1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase | False | 44 | 16260 | 3 | 83 | S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ | S-(hydroxymethyl)glutathione:NAD+ oxidoreductase | None | NAD-linked formaldehyde dehydrogenase (incorrect); formaldehyde dehydrogenase (incorrect); formic dehydrogenase (incorrect); class III alcohol dehydrogenase; ADH3; chi-ADH; FDH (incorrect); formaldehyde dehydrogenase (glutathione) (incorrect); GS-FDH (incorrect); glutathione-dependent formaldehyde dehydrogenase (incorrect); GD-FALDH; NAD- and glutathione-dependent formaldehyde dehydrogenase; NAD-dependent formaldehyde dehydrogenase (incorrect) | |
| 1.1.1.285 | 3''-deamino-3''-oxonicotianamine reductase | False | 6 | 4 | 0 | 1 | 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+ | 2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase | None | None | |
| 1.1.1.286 | isocitrate---homoisocitrate dehydrogenase | False | 3 | 8 | 0 | 6 | (1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH;;(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ | isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) | None | homoisocitrate---isocitrate dehydrogenase; PH1722 | |
| 1.1.1.287 | D-arabinitol dehydrogenase (NADP+) | False | 1 | 21 | 0 | 2 | (1) D-arabinitol + NADP+ = D-xylulose + NADPH + H+;;(2) D-arabinitol + NADP+ = D-ribulose + NADPH + H+ | D-arabinitol:NADP+ oxidoreductase | None | NADP+-dependent D-arabitol dehydrogenase; ARD1p; D-arabitol dehydrogenase 1 | |
| 1.1.1.288 | xanthoxin dehydrogenase | False | 1 | 56 | 0 | 9 | xanthoxin + NAD+ = abscisic aldehyde + NADH + H+ | xanthoxin:NAD+ oxidoreductase | None | xanthoxin oxidase; ABA2 | |
| 1.1.2.2 | mannitol dehydrogenase (cytochrome) | False | 0 | 3 | 0 | 2 | D-mannitol + a ferricytochrome c = D-fructose + a ferrocytochrome c + 2 H+ | D-mannitol:cytochrome-c 2-oxidoreductase | None | polyol dehydrogenase | |
| 1.1.2.3 | L-lactate dehydrogenase (cytochrome) | False | 3 | 2619 | 12 | 12 | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+ | (S)-lactate:ferricytochrome-c 2-oxidoreductase | None | lactic acid dehydrogenase; cytochrome b2 (flavin-free derivative of flavocytochrome b2); flavocytochrome b2; L-lactate cytochrome c reductase; L(+)-lactate:cytochrome c oxidoreductase; dehydrogenase, lactate (cytochrome); L-lactate cytochrome c oxidoreductase; lactate dehydrogenase (cytochrome); lactic cytochrome c reductase | |
| 1.1.2.4 | D-lactate dehydrogenase (cytochrome) | False | 9 | 15462 | 18 | 11 | (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+ | (R)-lactate:cytochrome-c 2-oxidoreductase | None | lactic acid dehydrogenase; D-lactate (cytochrome) dehydrogenase; cytochrome-dependent D-(-)-lactate dehydrogenase; D-lactate-cytochrome c reductase; D-(-)-lactic cytochrome c reductase | |
| 1.1.2.5 | D-lactate dehydrogenase (cytochrome c-553) | False | 0 | 21 | 0 | 1 | (R)-lactate + 2 ferricytochrome c-553 = pyruvate + 2 ferrocytochrome c-553 + 2 H+ | (R)-lactate:cytochrome-c-553 2-oxidoreductase | None | None | |
| 1.1.3.4 | glucose oxidase | False | 3 | 36 | 7 | 35 | beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2 | beta-D-glucose:oxygen 1-oxidoreductase | None | glucose oxyhydrase; corylophyline; penatin; glucose aerodehydrogenase; microcid; beta-D-glucose oxidase; D-glucose oxidase; D-glucose-1-oxidase; beta-D-glucose:quinone oxidoreductase; glucose oxyhydrase; deoxin-1; GOD | |
| 1.1.3.5 | hexose oxidase | False | 2 | 0 | 2 | 12 | D-glucose + O2 = D-glucono-1,5-lactone + H2O2 | D-hexose:oxygen 1-oxidoreductase | None | None | |
| 1.1.3.6 | cholesterol oxidase | False | 4 | 893 | 28 | 59 | cholesterol + O2 = cholest-5-en-3-one + H2O2 | cholesterol:oxygen oxidoreductase | None | cholesterol- O2 oxidoreductase; 3beta-hydroxy steroid oxidoreductase; 3beta-hydroxysteroid:oxygen oxidoreductase | |
| 1.1.3.7 | aryl-alcohol oxidase | False | 0 | 14 | 11 | 29 | an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2 | aryl-alcohol:oxygen oxidoreductase | None | aryl alcohol oxidase; veratryl alcohol oxidase; arom. alcohol oxidase | |
| 1.1.3.8 | L-gulonolactone oxidase | False | 13 | 2175 | 0 | 35 | L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 (overall reaction);;(1a) L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2;;(1b) L-xylo-hex-2-ulono-1,4-lactone = L-ascorbate (spontaneous) | L-gulono-1,4-lactone:oxygen 3-oxidoreductase | None | L-gulono-gamma-lactone: O2 oxidoreductase; L-gulono-gamma-lactone oxidase; L-gulono-gamma-lactone:oxidoreductase; GLO | |
| 1.1.3.9 | galactose oxidase | False | 2 | 178 | 16 | 17 | D-galactose + O2 = D-galacto-hexodialdose + H2O2 | D-galactose:oxygen 6-oxidoreductase | None | D-galactose oxidase; beta-galactose oxidase | |
| 1.1.3.10 | pyranose oxidase | False | 9 | 222 | 41 | 31 | D-glucose + O2 = 2-dehydro-D-glucose + H2O2 | pyranose:oxygen 2-oxidoreductase | None | glucose 2-oxidase; pyranose-2-oxidase | |
| 1.1.3.11 | L-sorbose oxidase | True | 0 | 0 | 0 | 1 | L-sorbose + O2 = 5-dehydro-D-fructose + H2O2 | L-sorbose:oxygen 5-oxidoreductase | None | None | |
| 1.1.3.12 | pyridoxine 4-oxidase | False | 1 | 18 | 2 | 5 | pyridoxine + O2 = pyridoxal + H2O2 | pyridoxine:oxygen 4-oxidoreductase | None | pyridoxin 4-oxidase; pyridoxol 4-oxidase | |
| 1.1.3.13 | alcohol oxidase | False | 6 | 741 | 13 | 48 | a primary alcohol + O2 = an aldehyde + H2O2 | alcohol:oxygen oxidoreductase (H2O2-forming) | None | ethanol oxidase; alcohol:oxygen oxidoreductase | |
| 1.1.3.14 | catechol oxidase (dimerizing) | True | 0 | 0 | 0 | 1 | 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O | catechol:oxygen oxidoreductase (dimerizing) | None | None | |
| 1.1.3.15 | (S)-2-hydroxy-acid oxidase | False | 29 | 4292 | 32 | 43 | an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2 | (S)-2-hydroxy carboxylate:oxygen 2-oxidoreductase | None | hydroxy-acid oxidase A; hydroxy-acid oxidase B; glycolate oxidase; L-2-hydroxy acid oxidase; hydroxyacid oxidase A; L-alpha-hydroxy acid oxidase | |
| 1.1.3.16 | ecdysone oxidase | False | 3 | 0 | 0 | 14 | ecdysone + O2 = 3-dehydroecdysone + H2O2 | ecdysone:oxygen 3-oxidoreductase | None | beta-ecdysone oxidase | |
| 1.1.3.17 | choline oxidase | False | 2 | 148 | 4 | 10 | choline + 2 O2 + H2O = betaine + 2 H2O2 (overall reaction);;(1a) choline + O2 = betaine aldehyde + H2O2;;(1b) betaine aldehyde + O2 + H2O = betaine + H2O2 | choline:oxygen 1-oxidoreductase | None | None | |
| 1.1.3.18 | secondary-alcohol oxidase | True | 0 | 0 | 0 | 8 | a secondary alcohol + O2 = a ketone + H2O2 | secondary-alcohol:oxygen oxidoreductase | None | polyvinyl alcohol oxidase; secondary alcohol oxidase | |
| 1.1.3.19 | 4-hydroxymandelate oxidase (decarboxylating) | True | 0 | 0 | 0 | 1 | (S)-4-hydroxymandelate + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2 | (S)-4-hydroxymandelate:oxygen 1-oxidoreductase (decarboxylating) | None | L-4-hydroxymandelate oxidase (decarboxylating); (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase; (S)-4-hydroxymandelate:oxygen 1-oxidoreductase; 4-hydroxymandelate oxidase | |
| 1.1.3.20 | long-chain-alcohol oxidase | False | 7 | 3080 | 0 | 15 | a long-chain alcohol + O2 = a long-chain aldehyde + H2O2 | long-chain-alcohol:oxygen oxidoreductase | None | long-chain fatty alcohol oxidase; fatty alcohol oxidase; fatty alcohol:oxygen oxidoreductase; long-chain fatty acid oxidase | |
| 1.1.3.21 | glycerol-3-phosphate oxidase | False | 10 | 945 | 2 | 10 | sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2 | sn-glycerol-3-phosphate:oxygen 2-oxidoreductase | None | glycerol phosphate oxidase; glycerol-1-phosphate oxidase; glycerol phosphate oxidase; L-alpha-glycerophosphate oxidase; alpha-glycerophosphate oxidase; L-alpha-glycerol-3-phosphate oxidase | |
| 1.1.3.23 | thiamine oxidase | True | 0 | 0 | 0 | 1 | thiamine + 2 O2 + H2O = thiamine acetic acid + 2 H2O2 | thiamine:oxygen 5-oxidoreductase | None | thiamin dehydrogenase; thiamine dehydrogenase; thiamin:oxygen 5-oxidoreductase | |
| 1.1.3.27 | hydroxyphytanate oxidase | True | 0 | 0 | 0 | 2 | L-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2 | L-2-hydroxyphytanate:oxygen 2-oxidoreductase | None | L-2-hydroxyphytanate:oxygen 2-oxidoreductase | |
| 1.1.3.28 | nucleoside oxidase | True | 0 | 0 | 0 | 1 | inosine + O2 = 9-riburonosylhypoxanthine + H2O;; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O;;(1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine | nucleoside:oxygen 5'-oxidoreductase | None | None | |
| 1.1.3.29 | N-acylhexosamine oxidase | False | 1 | 0 | 1 | 2 | (1) N-acetyl-D-glucosamine + O2 + H2O = N-acetyl-D-glucosaminate + H2O2 (overall reaction);;(1a) N-acetyl-D-glucosamine + O2 = N-acetyl-D-glucosamino-1,5-lactone + H2O2;;(1b) N-acetyl-D-glucosamino-1,5-lactone + H2O = N-acetyl-D-glucosaminate (spontaneous);;(2) N-acetyl-D-galactosamine + O2 + H2O = N-acetyl-D-galacotsaminate + H2O2 (overall reaction);;(2a) N-acetyl-D-galactosamine + O2 = N-acetyl-D-galactosamino-1,5-lactone + H2O2;;(2b) N-acetyl-D-galactosamino-1,5-lactone + H2O = N-acetyl-D-galactosaminate (spontaneous) | N-acyl-D-hexosamine:oxygen 1-oxidoreductase | None | N-acyl-D-hexosamine oxidase; N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase | |
| 1.1.3.30 | polyvinyl-alcohol oxidase | True | 0 | 0 | 0 | 11 | polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2 | polyvinyl-alcohol:oxygen oxidoreductase | None | dehydrogenase, polyvinyl alcohol; PVA oxidase | |
| 1.1.3.37 | D-arabinono-1,4-lactone oxidase | False | 9 | 2282 | 0 | 4 | D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 | D-arabinono-1,4-lactone:oxygen oxidoreductase | None | D-arabinono-gamma-lactone oxidase; ALO | |
| 1.1.3.38 | vanillyl-alcohol oxidase | False | 1 | 18 | 12 | 4 | vanillyl alcohol + O2 = vanillin + H2O2 | vanillyl alcohol:oxygen oxidoreductase | None | 4-hydroxy-2-methoxybenzyl alcohol oxidase | |
| 1.1.3.39 | nucleoside oxidase (H2O2-forming) | True | 0 | 0 | 0 | 1 | adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 (overall reaction);;(1a) adenosine + O2 = 5'-dehydroadenosine + H2O2;;(1b) 5'-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 | nucleoside:oxygen 5'-oxidoreductase (H2O2-forming) | None | None | |
| 1.1.3.40 | D-mannitol oxidase | False | 0 | 3 | 0 | 5 | D-mannitol + O2 = D-mannose + H2O2 | mannitol:oxygen oxidoreductase (cyclizing) | None | mannitol oxidase; D-arabitol oxidase | |
| 1.1.3.41 | alditol oxidase | False | 2 | 309 | 5 | 3 | an alditol + O2 = an aldose + H2O2 | alditol:oxygen oxidoreductase | None | xylitol oxidase; xylitol:oxygen oxidoreductase; AldO | |
| 1.1.5.2 | glucose 1-dehydrogenase (PQQ, quinone) | False | 3 | 2254 | 3 | 27 | D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol | D-glucose:ubiquinone oxidoreductase | None | quinoprotein glucose dehydrogenase; membrane-bound glucose dehydrogenase; mGDH; glucose dehydrogenase (PQQ-dependent); glucose dehydrogenase (pyrroloquinoline-quinone); quinoprotein D-glucose dehydrogenase | |
| 1.1.99.1 | choline dehydrogenase | False | 122 | 12010 | 0 | 9 | choline + acceptor = betaine aldehyde + reduced acceptor | choline:acceptor 1-oxidoreductase | None | choline oxidase; choline-cytochrome c reductase; choline:(acceptor) oxidoreductase; choline:(acceptor) 1-oxidoreductase | |
| 1.1.99.2 | L-2-hydroxyglutarate dehydrogenase | False | 12 | 4112 | 0 | 5 | (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor | (S)-2-hydroxyglutarate:acceptor 2-oxidoreductase | None | alpha-ketoglutarate reductase; alpha-hydroxyglutarate dehydrogenase; L-alpha-hydroxyglutarate dehydrogenase; hydroxyglutaric dehydrogenase; alpha-hydroxyglutarate oxidoreductase; L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase; alpha-hydroxyglutarate dehydrogenase (NAD+ specific); (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase | |
| 1.1.99.3 | gluconate 2-dehydrogenase (acceptor) | False | 3 | 1753 | 0 | 11 | D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor | D-gluconate:acceptor 2-oxidoreductase | None | gluconate oxidase; gluconate dehydrogenase; gluconic dehydrogenase; D-gluconate dehydrogenase; gluconic acid dehydrogenase; 2-ketogluconate reductase; D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding; D-gluconate:(acceptor) 2-oxidoreductase | |
| 1.1.99.4 | dehydrogluconate dehydrogenase | False | 0 | 67 | 0 | 13 | 2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor | 2-dehydro-D-gluconate:acceptor 2-oxidoreductase | None | ketogluconate dehydrogenase; alpha-ketogluconate dehydrogenase; 2-keto-D-gluconate dehydrogenase; 2-oxogluconate dehydrogenase | |
| 1.1.99.6 | D-lactate dehydrogenase (acceptor) | False | 2 | 22 | 0 | 8 | (R)-lactate + acceptor = pyruvate + reduced acceptor | (R)-lactate:acceptor 2-oxidoreductase | None | D-2-hydroxy acid dehydrogenase; D-2-hydroxy-acid dehydrogenase; (R)-2-hydroxy-acid:acceptor 2-oxidoreductase | |
| 1.1.99.7 | lactate---malate transhydrogenase | True | 0 | 0 | 0 | 1 | (S)-lactate + oxaloacetate = pyruvate + malate | (S)-lactate:oxaloacetate oxidoreductase | None | malate-lactate transhydrogenase | |
| 1.1.99.9 | pyridoxine 5-dehydrogenase | True | 0 | 0 | 0 | 2 | pyridoxine + acceptor = isopyridoxal + reduced acceptor | pyridoxine:acceptor 5-oxidoreductase | None | pyridoxal-5-dehydrogenase; pyridoxol 5-dehydrogenase; pyridoxin 5-dehydrogenase; pyridoxine dehydrogenase; pyridoxine 5'-dehydrogenase; pyridoxine:(acceptor) 5-oxidoreductase | |
| 1.1.99.12 | sorbose dehydrogenase | False | 0 | 3 | 0 | 3 | L-sorbose + acceptor = 5-dehydro-D-fructose + reduced acceptor | L-sorbose:acceptor 5-oxidoreductase | None | L-sorbose:(acceptor) 5-oxidoreductase | |
| 1.1.99.13 | glucoside 3-dehydrogenase (acceptor) | False | 0 | 5 | 0 | 6 | sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor | D-aldohexoside:acceptor 3-oxidoreductase | None | D-glucoside 3-dehydrogenase (ambiguous); D-aldohexopyranoside dehydrogenase (ambiguous); D-aldohexoside:(acceptor) 3-oxidoreductase; thuA (gene name); thuB (gene name); glucoside 3-dehydrogenase | |
| 1.1.99.14 | glycolate dehydrogenase | False | 6 | 17331 | 0 | 11 | glycolate + acceptor = glyoxylate + reduced acceptor | glycolate:acceptor 2-oxidoreductase | None | glycolate oxidoreductase; glycolic acid dehydrogenase; glycolate:(acceptor) 2-oxidoreductase | |
| 1.1.99.18 | cellobiose dehydrogenase (acceptor) | False | 1 | 62 | 3 | 55 | cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor | cellobiose:acceptor 1-oxidoreductase | None | cellobiose dehydrogenase; cellobiose oxidoreductase; Phanerochaete chrysosporium cellobiose oxidoreductase; CBOR; cellobiose oxidase; cellobiose:oxygen 1-oxidoreductase; CDH; cellobiose:(acceptor) 1-oxidoreductase | |
| 1.1.99.20 | alkan-1-ol dehydrogenase (acceptor) | True | 0 | 0 | 0 | 6 | primary alcohol + acceptor = aldehyde + reduced acceptor | alkan-1-ol:acceptor oxidoreductase | None | polyethylene glycol dehydrogenase; alkan-1-ol:(acceptor) oxidoreductase | |
| 1.1.99.21 | D-sorbitol dehydrogenase (acceptor) | False | 0 | 433 | 0 | 3 | D-sorbitol + acceptor = L-sorbose + reduced acceptor | D-sorbitol:acceptor 1-oxidoreductase | None | D-sorbitol:(acceptor) 1-oxidoreductase | |
| 1.1.99.22 | glycerol dehydrogenase (acceptor) | False | 4 | 72 | 0 | 5 | glycerol + acceptor = glycerone + reduced acceptor | glycerol:acceptor 1-oxidoreductase | None | glycerol:(acceptor) 1-oxidoreductase | |
| 1.1.99.24 | hydroxyacid-oxoacid transhydrogenase | False | 14 | 4407 | 0 | 19 | (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase | None | transhydrogenase, hydroxy acid-oxo acid | |
| 1.1.99.26 | 3-hydroxycyclohexanone dehydrogenase | True | 0 | 0 | 0 | 1 | 3-hydroxycyclohexanone + acceptor = cyclohexane-1,3-dione + reduced acceptor | 3-hydroxycyclohexanone:acceptor 1-oxidoreductase | None | None | |
| 1.1.99.27 | (R)-pantolactone dehydrogenase (flavin) | False | 0 | 1 | 0 | 1 | (R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor | (R)-pantolactone:acceptor oxidoreductase (flavin-containing) | None | 2-dehydropantolactone reductase (flavin); 2-dehydropantoyl-lactone reductase (flavin); (R)-pantoyllactone dehydrogenase (flavin) | |
| 1.1.99.28 | glucose-fructose oxidoreductase | False | 1 | 1736 | 7 | 3 | D-glucose + D-fructose = D-gluconolactone + D-glucitol | D-glucose:D-fructose oxidoreductase | None | None | |
| 1.1.99.29 | pyranose dehydrogenase (acceptor) | False | 6 | 1154 | 1 | 5 | (1) a pyranose + acceptor = a pyranos-2-ulose (or a pyranos-3-ulose or a pyranos-2,3-diulose) + reduced acceptor;;(2) a pyranoside + acceptor = a pyranosid-3-ulose (or a pyranosid-3,4-diulose) + reduced acceptor | pyranose:acceptor oxidoreductase | None | pyranose dehydrogenase; pyranose-quinone oxidoreductase; quinone-dependent pyranose dehydrogenase; PDH | |
| 1.1.99.30 | 2-oxo-acid reductase | False | 1 | 0 | 0 | 3 | a (2R)-hydroxy-carboxylate + acceptor = a 2-oxocarboxylate + reduced acceptor | (2R)-hydroxy-carboxylate:acceptor oxidoreductase | None | (2R)-hydroxycarboxylate-viologen-oxidoreductase; HVOR; 2-oxoacid reductase | |
| 1.2.1.3 | aldehyde dehydrogenase (NAD+) | False | 137 | 24464 | 61 | 45 | an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+ | aldehyde:NAD+ oxidoreductase | None | CoA-independent aldehyde dehydrogenase; m-methylbenzaldehyde dehydrogenase; NAD-aldehyde dehydrogenase; NAD-dependent 4-hydroxynonenal dehydrogenase; NAD-dependent aldehyde dehydrogenase; NAD-linked aldehyde dehydrogenase; propionaldehyde dehydrogenase; aldehyde dehydrogenase (NAD) | |
| 1.2.1.4 | aldehyde dehydrogenase (NADP+) | False | 6 | 914 | 1 | 26 | an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ | aldehyde:NADP+ oxidoreductase | None | NADP-acetaldehyde dehydrogenase; NADP-dependent aldehyde dehydrogenase; aldehyde dehydrogenase (NADP) | |
| 1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] | False | 14 | 1648 | 13 | 18 | an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+ | aldehyde:NAD(P)+ oxidoreductase | None | ALDH | |
| 1.2.1.7 | benzaldehyde dehydrogenase (NADP+) | False | 5 | 1 | 0 | 7 | benzaldehyde + NADP+ + H2O = benzoate + NADPH + 2 H+ | benzaldehyde:NADP+ oxidoreductase | None | NADP+-linked benzaldehyde dehydrogenase; benzaldehyde dehydrogenase (NADP+) | |
| 1.2.1.8 | betaine-aldehyde dehydrogenase | False | 250 | 12198 | 34 | 60 | betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ | betaine-aldehyde:NAD+ oxidoreductase | None | betaine aldehyde oxidase; BADH; betaine aldehyde dehydrogenase; BetB | |
| 1.2.1.9 | glyceraldehyde-3-phosphate dehydrogenase (NADP+) | False | 9 | 1694 | 17 | 40 | D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + 2 H+ | D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase | None | triosephosphate dehydrogenase (ambiguous); glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate); glyceraldehyde phosphate dehydrogenase (NADP+); glyceraldehyde 3-phosphate dehydrogenase (NADP+); NADP+-glyceraldehyde phosphate dehydrogenase; NADP+-glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate:NADP+ reductase; nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase | |
| 1.2.1.10 | acetaldehyde dehydrogenase (acetylating) | False | 171 | 7890 | 6 | 20 | acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+ | acetaldehyde:NAD+ oxidoreductase (CoA-acetylating) | None | aldehyde dehydrogenase (acylating); ADA; acylating acetaldehyde dehyrogenase; DmpF; BphJ | |
| 1.2.1.11 | aspartate-semialdehyde dehydrogenase | False | 50 | 44609 | 58 | 29 | L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+ | L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) | None | aspartate semialdehyde dehydrogenase; aspartic semialdehyde dehydrogenase; L-aspartate-beta-semialdehyde:NADP+ oxidoreductase (phosphorylating); aspartic beta-semialdehyde dehydrogenase; ASA dehydrogenase | |
| 1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | False | 257 | 13346 | 146 | 123 | D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ | D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) | None | triosephosphate dehydrogenase (ambiguous); glyceraldehyde phosphate dehydrogenase; phosphoglyceraldehyde dehydrogenase; 3-phosphoglyceraldehyde dehydrogenase; NAD+-dependent glyceraldehyde phosphate dehydrogenase; glyceraldehyde phosphate dehydrogenase (NAD+); glyceraldehyde-3-phosphate dehydrogenase (NAD+); NADH-glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-P-dehydrogenase | |
| 1.2.1.13 | glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) | False | 16 | 92 | 27 | 44 | D-glyceraldehyde 3-phosphate + phosphate + NADP+ = 3-phospho-D-glyceroyl phosphate + NADPH + H+ | D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating) | None | triosephosphate dehydrogenase (NADP+); dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating); glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating); NADP+-glyceraldehyde-3-phosphate dehydrogenase; NADP+-glyceraldehyde phosphate dehydrogenase; NADP+-dependent glyceraldehyde phosphate dehydrogenase; NADP+-triose phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating); GAPDH | |
| 1.2.1.15 | malonate-semialdehyde dehydrogenase | True | 0 | 0 | 0 | 3 | 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + 2 H+ | 3-oxopropanoate:NAD(P)+ oxidoreductase | None | None | |
| 1.2.1.16 | succinate-semialdehyde dehydrogenase [NAD(P)+] | False | 6 | 8535 | 6 | 21 | succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + 2 H+ | succinate-semialdehyde:NAD(P)+ oxidoreductase | None | succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)); succinate-semialdehyde dehydrogenase [NAD(P)] | |
| 1.2.1.17 | glyoxylate dehydrogenase (acylating) | False | 0 | 2 | 0 | 7 | glyoxylate + CoA + NADP+ = oxalyl-CoA + NADPH + H+ | glyoxylate:NADP+ oxidoreductase (CoA-oxalylating) | None | None | |
| 1.2.1.18 | malonate-semialdehyde dehydrogenase (acetylating) | False | 0 | 151 | 0 | 7 | 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H | 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating) | None | malonic semialdehyde oxidative decarboxylase | |
| 1.2.1.19 | aminobutyraldehyde dehydrogenase | False | 65 | 5670 | 7 | 24 | 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ | 4-aminobutanal:NAD+ 1-oxidoreductase | None | gamma-guanidinobutyraldehyde dehydrogenase (ambiguous); ABAL dehydrogenase; 4-aminobutyraldehyde dehydrogenase; 4-aminobutanal dehydrogenase; gamma-aminobutyraldehyde dehydroganase; 1-pyrroline dehydrogenase; ABALDH; YdcW | |
| 1.2.1.20 | glutarate-semialdehyde dehydrogenase | False | 0 | 1945 | 0 | 4 | 5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+ | glutarate-semialdehyde:NADP+ oxidoreductase | None | glutarate semialdehyde dehydrogenase; davD (gene name) | |
| 1.2.1.21 | glycolaldehyde dehydrogenase | False | 1 | 126 | 1 | 19 | glycolaldehyde + NAD+ + H2O = glycolate + NADH + 2 H+ | glycolaldehyde:NAD+ oxidoreductase | None | glycol aldehyde dehydrogenase | |
| 1.2.1.22 | lactaldehyde dehydrogenase | False | 7 | 1159 | 7 | 11 | (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + 2 H+ | (S)-lactaldehyde:NAD+ oxidoreductase | None | L-lactaldehyde:NAD oxidoreductase; nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase | |
| 1.2.1.23 | 2-oxoaldehyde dehydrogenase (NAD+) | True | 0 | 0 | 0 | 7 | a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ | 2-oxoaldehyde:NAD+ 2-oxidoreductase | None | alpha-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NAD+-linked alpha-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NAD+-dependent alpha-ketoaldehyde dehydrogenase | |
| 1.2.1.24 | succinate-semialdehyde dehydrogenase (NAD+) | False | 12 | 3992 | 5 | 31 | succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ | succinate-semialdehyde:NAD+ oxidoreductase | None | succinate semialdehyde dehydrogenase (NAD+); succinic semialdehyde dehydrogenase (NAD+); succinyl semialdehyde dehydrogenase (NAD+); succinate semialdehyde:NAD+ oxidoreductase | |
| 1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system | False | 0 | 9 | 0 | 8 | 3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH | 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methylpropanoylating) | None | branched-chain alpha-keto acid dehydrogenase complex; 2-oxoisovalerate dehydrogenase; alpha-ketoisovalerate dehydrogenase; 2-oxoisovalerate dehydrogenase (acylating) | |
| 1.2.1.26 | 2,5-dioxovalerate dehydrogenase | False | 7 | 866 | 2 | 12 | 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + 2 H+ | 2,5-dioxopentanoate:NADP+ 5-oxidoreductase | None | 2-oxoglutarate semialdehyde dehydrogenase; alpha-ketoglutaric semialdehyde dehydrogenase | |
| 1.2.1.27 | methylmalonate-semialdehyde dehydrogenase (CoA-acylating) | False | 53 | 27513 | 4 | 11 | 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH | 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating) | None | MSDH; MMSA dehydrogenase; iolA (gene name); methylmalonate-semialdehyde dehydrogenase (acylating) | |
| 1.2.1.28 | benzaldehyde dehydrogenase (NAD+) | False | 20 | 671 | 2 | 10 | benzaldehyde + NAD+ + H2O = benzoate + NADH + 2 H+ | benzaldehyde:NAD+ oxidoreductase | None | benzaldehyde (NAD+) dehydrogenase; benzaldehyde dehydrogenase (NAD+) | |
| 1.2.1.29 | aryl-aldehyde dehydrogenase | True | 0 | 0 | 0 | 3 | an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+ | aryl-aldehyde:NAD+ oxidoreductase | None | None | |
| 1.2.1.30 | carboxylate reductase (NADP+) | False | 2 | 4 | 0 | 21 | an aromatic aldehyde + NADP+ + AMP + diphosphate = an aromatic acid + NADPH + H+ + ATP | aryl-aldehyde:NADP+ oxidoreductase (ATP-forming) | None | aromatic acid reductase; aryl-aldehyde dehydrogenase (NADP+) | |
| 1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase | False | 12 | 1619 | 22 | 17 | (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ (overall reaction);;(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous);;(1b) (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD(P)+ + 2 H2O = L-2-aminoadipate + NAD(P)H + H+ | (S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase | None | aminoadipate semialdehyde dehydrogenase; 2-aminoadipate semialdehyde dehydrogenase; alpha-aminoadipate-semialdehyde dehydrogenase; alpha-aminoadipate reductase; 2-aminoadipic semialdehyde dehydrogenase; L-alpha-aminoadipate delta-semialdehyde oxidoreductase; L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase; L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase; L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase | |
| 1.2.1.32 | aminomuconate-semialdehyde dehydrogenase | False | 5 | 348 | 1 | 14 | 2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + 2 H+ | 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase | None | 2-aminomuconate semialdehyde dehydrogenase; 2-hydroxymuconic acid semialdehyde dehydrogenase; 2-hydroxymuconate semialdehyde dehydrogenase; alpha-aminomuconic epsilon-semialdehyde dehydrogenase; alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase; 2-hydroxymuconic semialdehyde dehydrogenase | |
| 1.2.1.33 | (R)-dehydropantoate dehydrogenase | True | 0 | 0 | 0 | 2 | (R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + 2 H+ | (R)-4-dehydropantoate:NAD+ 4-oxidoreductase | None | D-aldopantoate dehydrogenase; D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase | |
| 1.2.1.36 | retinal dehydrogenase | False | 18 | 1722 | 21 | 12 | retinal + NAD+ + H2O = retinoate + NADH + 2 H+ | retinal:NAD+ oxidoreductase | None | cytosolic retinal dehydrogenase | |
| 1.2.1.38 | N-acetyl-gamma-glutamyl-phosphate reductase | False | 397 | 35397 | 18 | 7 | N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-L-glutamyl 5-phosphate + NADPH + H+ | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | None | reductase, acetyl-gamma-glutamyl phosphate; N-acetylglutamate 5-semialdehyde dehydrogenase; N-acetylglutamic gamma-semialdehyde dehydrogenase; N-acetyl-L-glutamate gamma-semialdehyde:NADP+ oxidoreductase (phosphorylating) | |
| 1.2.1.39 | phenylacetaldehyde dehydrogenase | False | 3 | 951 | 1 | 13 | phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + 2 H+ | phenylacetaldehyde:NAD+ oxidoreductase | None | None | |
| 1.2.1.41 | glutamate-5-semialdehyde dehydrogenase | False | 578 | 38856 | 4 | 19 | L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH + H+ | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | None | beta-glutamylphosphate reductase; gamma-glutamyl phosphate reductase; beta-glutamylphosphate reductase; glutamate semialdehyde dehydrogenase; glutamate-gamma-semialdehyde dehydrogenase | |
| 1.2.1.42 | hexadecanal dehydrogenase (acylating) | False | 0 | 6 | 0 | 16 | hexadecanal + CoA + NAD+ = hexadecanoyl-CoA + NADH + H+ | hexadecanal:NAD+ oxidoreductase (CoA-acylating) | None | fatty acyl-CoA reductase | |
| 1.2.1.44 | cinnamoyl-CoA reductase | False | 7 | 148 | 0 | 40 | cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+ | cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating) | None | feruloyl-CoA reductase; cinnamoyl-coenzyme A reductase; ferulyl-CoA reductase; feruloyl coenzyme A reductase; p-hydroxycinnamoyl coenzyme A reductase; cinnamoyl-CoA:NADPH reductase | |
| 1.2.1.81 | sulfoacetaldehyde dehydrogenase (acylating) | False | 2 | 113 | 0 | 1 | 2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+ | 2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating) | None | SauS | |
| 1.2.1.46 | formaldehyde dehydrogenase | False | 8 | 3978 | 1 | 20 | formaldehyde + NAD+ + H2O = formate + NADH + 2 H+ | formaldehyde:NAD+ oxidoreductase | None | NAD+-linked formaldehyde dehydrogenase; NAD+-dependent formaldehyde dehydrogenase | |
| 1.2.1.47 | 4-trimethylammoniobutyraldehyde dehydrogenase | False | 18 | 2133 | 5 | 5 | 4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+ | 4-trimethylammoniobutanal:NAD+ 1-oxidoreductase | None | 4-trimethylaminobutyraldehyde dehydrogenase; 4-N-trimethylaminobutyraldehyde dehydrogenase | |
| 1.2.1.48 | long-chain-aldehyde dehydrogenase | False | 1 | 76 | 0 | 13 | a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + 2 H+ | long-chain-aldehyde:NAD+ oxidoreductase | None | long-chain aliphatic aldehyde dehydrogenase; long-chain fatty aldehyde dehydrogenase; fatty aldehyde:NAD+ oxidoreductase | |
| 1.2.1.49 | 2-oxoaldehyde dehydrogenase (NADP+) | True | 0 | 0 | 0 | 4 | a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+ | 2-oxoaldehyde:NADP+ 2-oxidoreductase | None | alpha-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP+-linked alpha-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP+-dependent alpha-ketoaldehyde dehydrogenase | |
| 1.2.1.50 | long-chain acyl-protein thioester reductase | False | 7 | 1680 | 1 | 10 | a long-chain aldehyde + [protein]-L-cysteine + NADP+ = a [protein]-S-(long-chain fatty acyl)-L-cysteine + NADPH + H+;; | long-chain-aldehyde:NADP+ oxidoreductase (protein thioester-forming) | None | luxC (gene name); acyl-CoA reductase; acyl coenzyme A reductase; long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming); long-chain-fatty-acyl-CoA reductase | |
| 1.2.1.51 | pyruvate dehydrogenase (NADP+) | False | 2 | 47 | 0 | 3 | pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH | pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating) | None | None | |
| 1.2.1.52 | oxoglutarate dehydrogenase (NADP+) | False | 0 | 9 | 0 | 2 | 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH | 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) | None | oxoglutarate dehydrogenase (NADP+) | |
| 1.2.1.53 | 4-hydroxyphenylacetaldehyde dehydrogenase | True | 0 | 0 | 0 | 1 | 4-hydroxyphenylacetaldehyde + NAD+ + H2O = 4-hydroxyphenylacetate + NADH + 2 H+ | 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase | None | 4-HPAL dehydrogenase | |
| 1.2.1.54 | gamma-guanidinobutyraldehyde dehydrogenase | False | 9 | 49 | 1 | 3 | 4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + 2 H+ | 4-guanidinobutanal:NAD+ 1-oxidoreductase | None | alpha-guanidinobutyraldehyde dehydrogenase; 4-guanidinobutyraldehyde dehydrogenase; GBAL dehydrogenase | |
| 1.2.1.57 | butanal dehydrogenase | True | 0 | 0 | 0 | 5 | butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+ | butanal:NAD(P)+ oxidoreductase (CoA-acylating) | None | None | |
| 1.2.1.58 | phenylglyoxylate dehydrogenase (acylating) | False | 5 | 497 | 0 | 2 | phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH | phenylglyoxylate:NAD+ oxidoreductase | None | None | |
| 1.2.1.59 | glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) | False | 61 | 3653 | 2 | 28 | D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+ | D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating) | None | triosephosphate dehydrogenase (NAD(P)); glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating) | |
| 1.2.1.60 | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | False | 1 | 452 | 1 | 4 | 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+ | 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase | None | carboxymethylhydroxymuconic semialdehyde dehydrogenase | |
| 1.2.1.61 | 4-hydroxymuconic-semialdehyde dehydrogenase | False | 0 | 3 | 0 | 4 | 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + 2 H+ | 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase | None | None | |
| 1.2.1.62 | 4-formylbenzenesulfonate dehydrogenase | False | 1 | 543 | 1 | 1 | 4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH + 2 H+ | 4-formylbenzenesulfonate:NAD+ oxidoreductase | None | None | |
| 1.2.1.63 | 6-oxohexanoate dehydrogenase | False | 0 | 3 | 0 | 3 | 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + 2 H+ | 6-oxohexanoate:NADP+ oxidoreductase | None | None | |
| 1.2.1.64 | 4-hydroxybenzaldehyde dehydrogenase (NAD+) | False | 2 | 6 | 0 | 4 | 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + 2 H+ | 4-hydroxybenzaldehyde:NAD+ oxidoreductase | None | p-hydroxybenzaldehyde dehydrogenase (ambiguous); 4-hydroxybenzaldehyde dehydrogenase (ambiguous) | |
| 1.2.1.65 | salicylaldehyde dehydrogenase | False | 2 | 54 | 1 | 5 | salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+ | salicylaldehyde:NAD+ oxidoreductase | None | None | |
| 1.2.1.67 | vanillin dehydrogenase | False | 5 | 178 | 0 | 18 | vanillin + NAD+ + H2O = vanillate + NADH + 2 H+ | vanillin:NAD+ oxidoreductase | None | None | |
| 1.2.1.68 | coniferyl-aldehyde dehydrogenase | False | 3 | 157 | 0 | 3 | coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + 2 H+ | coniferyl aldehyde:NAD(P)+ oxidoreductase | None | None | |
| 1.2.1.69 | fluoroacetaldehyde dehydrogenase | False | 1 | 3 | 0 | 1 | fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+ | fluoroacetaldehyde:NAD+ oxidoreductase | None | None | |
| 1.2.1.70 | glutamyl-tRNA reductase | False | 583 | 29002 | 6 | 18 | L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+ | L-glutamate-semialdehyde:NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming) | None | None | |
| 1.2.2.1 | formate dehydrogenase (cytochrome) | False | 0 | 78 | 0 | 2 | formate + 2 ferricytochrome b1 = CO2 + 2 ferrocytochrome b1 + 2 H+ | formate:ferricytochrome-b1 oxidoreductase | None | formate dehydrogenase; formate:cytochrome b1 oxidoreductase | |
| 1.2.3.1 | aldehyde oxidase | False | 25 | 963 | 10 | 52 | an aldehyde + H2O + O2 = a carboxylate + H2O2 | aldehyde:oxygen oxidoreductase | None | quinoline oxidase; retinal oxidase | |
| 1.2.3.3 | pyruvate oxidase | False | 2 | 1193 | 15 | 18 | pyruvate + phosphate + O2 = acetyl phosphate + CO2 + H2O2 | pyruvate:oxygen 2-oxidoreductase (phosphorylating) | None | pyruvic oxidase; phosphate-dependent pyruvate oxidase | |
| 1.2.3.4 | oxalate oxidase | False | 4 | 53 | 5 | 26 | oxalate + O2 + 2 H+ = 2 CO2 + H2O2 | oxalate:oxygen oxidoreductase | None | aero-oxalo dehydrogenase; oxalic acid oxidase | |
| 1.2.3.5 | glyoxylate oxidase | False | 4 | 3 | 0 | 3 | glyoxylate + H2O + O2 = oxalate + H2O2 | glyoxylate:oxygen oxidoreductase | None | None | |
| 1.2.3.6 | pyruvate oxidase (CoA-acetylating) | True | 0 | 0 | 0 | 2 | pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2 | pyruvate:oxygen 2-oxidoreductase (CoA-acetylating) | None | None | |
| 1.2.3.7 | indole-3-acetaldehyde oxidase | False | 6 | 7 | 0 | 5 | (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 | (indol-3-yl)acetaldehyde:oxygen oxidoreductase | None | indoleacetaldehyde oxidase; IAAld oxidase; AO1; indole-3-acetaldehyde:oxygen oxidoreductase | |
| 1.2.3.8 | pyridoxal oxidase | False | 0 | 1 | 1 | 1 | pyridoxal + H2O + O2 = 4-pyridoxate + (?) | pyridoxal:oxygen 4-oxidoreductase | None | None | |
| 1.2.3.9 | aryl-aldehyde oxidase | False | 0 | 5 | 0 | 3 | an aromatic aldehyde + O2 + H2O = an aromatic carboxylate + H2O2 | aryl-aldehyde:oxygen oxidoreductase | None | None | |
| 1.2.3.13 | 4-hydroxyphenylpyruvate oxidase | True | 0 | 0 | 0 | 1 | 2 4-hydroxyphenylpyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2 | 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) | None | None | |
| 1.2.3.14 | abscisic-aldehyde oxidase | False | 1 | 7 | 0 | 8 | abscisic aldehyde + H2O + O2 = abscisate + H2O2 | abscisic-aldehyde:oxygen oxidoreductase | None | abscisic aldehyde oxidase; AAO3; AOd; AOdelta | |
| 1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) | False | 120 | 79436 | 26 | 29 | pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 | pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) | None | pyruvate decarboxylase (ambiguous); pyruvate dehydrogenase (ambiguous); pyruvate dehydrogenase (lipoamide); pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating); pyruvic acid dehydrogenase; pyruvic dehydrogenase (ambiguous) | |
| 1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) | False | 103 | 28263 | 20 | 22 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) | None | 2-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase; 2-oxoglutarate: lipoate oxidoreductase; 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating); alpha-ketoglutarate dehydrogenase; alphaketoglutaric acid dehydrogenase; alpha-ketoglutaric dehydrogenase; alpha-oxoglutarate dehydrogenase; AKGDH; OGDC; ketoglutaric dehydrogenase; oxoglutarate decarboxylase (misleading); oxoglutarate dehydrogenase; oxoglutarate dehydrogenase (lipoamide) | |
| 1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) | False | 32 | 21026 | 33 | 21 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | None | 2-oxoisocaproate dehydrogenase; 2-oxoisovalerate (lipoate) dehydrogenase; 3-methyl-2-oxobutanoate dehydrogenase (lipoamide); 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating); alpha-keto-alpha-methylvalerate dehydrogenase; alpha-ketoisocaproate dehydrogenase; alpha-ketoisocaproic dehydrogenase; alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase; alpha-ketoisovalerate dehydrogenase; alpha-oxoisocaproate dehydrogenase; BCKDH (ambiguous); BCOAD; branched chain keto acid dehydrogenase; branched-chain (-2-oxoacid) dehydrogenase (BCD); branched-chain 2-keto acid dehydrogenase; branched-chain 2-oxo acid dehydrogenase; branched-chain alpha-keto acid dehydrogenase; branched-chain alpha-oxo acid dehydrogenase; branched-chain keto acid dehydrogenase; branched-chain ketoacid dehydrogenase; dehydrogenase, 2-oxoisovalerate (lipoate); dehydrogenase, branched chain alpha-keto acid | |
| 1.2.7.1 | pyruvate synthase | False | 29 | 10069 | 12 | 29 | pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ | pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating) | None | pyruvate oxidoreductase; pyruvate synthetase; pyruvate:ferredoxin oxidoreductase; pyruvic-ferredoxin oxidoreductase; 2-oxobutyrate synthase; alpha-ketobutyrate-ferredoxin oxidoreductase; 2-ketobutyrate synthase; alpha-ketobutyrate synthase; 2-oxobutyrate-ferredoxin oxidoreductase; 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating); 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating) | |
| 1.2.7.3 | 2-oxoglutarate synthase | False | 14 | 4935 | 0 | 7 | 2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ | 2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating) | None | 2-ketoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin oxidoreductase; KGOR; 2-oxoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating) | |
| 1.2.7.4 | anaerobic carbon monoxide dehydrogenase | False | 26 | 7159 | 53 | 40 | CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+ | carbon-monoxide,water:ferredoxin oxidoreductase | None | Ni-CODH; carbon-monoxide dehydrogenase (ferredoxin) | |
| 1.2.7.5 | aldehyde ferredoxin oxidoreductase | False | 5 | 6628 | 0 | 14 | an aldehyde + H2O + 2 oxidized ferredoxin = a carboxylate + 2 H+ + 2 reduced ferredoxin | aldehyde:ferredoxin oxidoreductase | None | AOR | |
| 1.2.7.6 | glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) | False | 1 | 42 | 0 | 5 | D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin | D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase | None | GAPOR; glyceraldehyde-3-phosphate Fd oxidoreductase; glyceraldehyde-3-phosphate ferredoxin reductase | |
| 1.2.7.7 | 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) | False | 20 | 1439 | 0 | 8 | 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+ | 3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating) | None | 2-ketoisovalerate ferredoxin reductase; 3-methyl-2-oxobutanoate synthase (ferredoxin); VOR; branched-chain ketoacid ferredoxin reductase; branched-chain oxo acid ferredoxin reductase; keto-valine-ferredoxin oxidoreductase; ketoisovalerate ferredoxin reductase; 2-oxoisovalerate ferredoxin reductase | |
| 1.2.7.8 | indolepyruvate ferredoxin oxidoreductase | False | 12 | 11064 | 0 | 5 | (indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+ | 3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating) | None | 3-(indol-3-yl)pyruvate synthase (ferredoxin); IOR | |
| 1.2.99.6 | carboxylate reductase | False | 6 | 588 | 1 | 6 | an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor | aldehyde:acceptor oxidoreductase | None | aldehyde:(acceptor) oxidoreductase | |
| 1.2.99.7 | aldehyde dehydrogenase (FAD-independent) | False | 1 | 313 | 10 | 4 | an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor | aldehyde:acceptor oxidoreductase (FAD-independent) | None | aldehyde oxidase; aldehyde oxidoreductase; Mop; AORDd | |
| 1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) | False | 7 | 995 | 0 | 10 | (1) 5,6-dihydrouracil + NAD+ = uracil + NADH + H+;;(2) 5,6-dihydrothymine + NAD+ = thymine + NADH + H+ | 5,6-dihydropyrimidine:NAD+ oxidoreductase | None | dihydropyrimidine dehydrogenase; dihydrothymine dehydrogenase; pyrimidine reductase; thymine reductase; uracil reductase; dihydrouracil dehydrogenase (NAD+) | |
| 1.3.1.2 | dihydropyrimidine dehydrogenase (NADP+) | False | 11 | 2517 | 13 | 9 | 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ | 5,6-dihydrouracil:NADP+ 5-oxidoreductase | None | dihydrothymine dehydrogenase; dihydrouracil dehydrogenase (NADP+); 4,5-dihydrothymine: oxidoreductase; DPD; DHPDH; dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate); DHU dehydrogenase; hydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase (NADP) | |
| 1.3.1.3 | Delta4-3-oxosteroid 5beta-reductase | False | 6 | 32 | 15 | 16 | a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH + H+ | 3-oxo-5beta-steroid:NADP+ 4,5-oxidoreductase | None | 3-oxo-Delta4-steroid 5beta-reductase; 5beta-reductase; androstenedione 5beta-reductase; cholestenone 5beta-reductase; cortisone 5beta-reductase; cortisone beta-reductase; cortisone Delta4-5beta-reductase; steroid 5beta-reductase; testosterone 5beta-reductase; Delta4-3-ketosteroid 5beta-reductase; Delta4-5beta-reductase; Delta4-hydrogenase; 4,5beta-dihydrocortisone:NADP+ Delta4-oxidoreductase; 3-oxo-5beta-steroid:NADP+ Delta4-oxidoreductase; 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase | |
| 1.3.1.5 | cucurbitacin Delta23-reductase | True | 0 | 0 | 0 | 1 | 23,24-dihydrocucurbitacin B + NAD(P)+ = cucurbitacin B + NAD(P)H + H+ | 23,24-dihydrocucurbitacin:NAD(P)+ Delta23-oxidoreductase | None | NAD(P)H: cucurbitacin B Delta23-oxidoreductase | |
| 1.3.1.6 | fumarate reductase (NADH) | False | 4 | 924 | 3 | 26 | succinate + NAD+ = fumarate + NADH + H+ | succinate:NAD+ oxidoreductase | None | NADH-fumarate reductase; NADH-dependent fumarate reductase; fumarate reductase (NADH) | |
| 1.3.1.7 | meso-tartrate dehydrogenase | True | 0 | 0 | 0 | 5 | meso-tartrate + NAD+ = dihydroxyfumarate + NADH + H+ | meso-tartrate:NAD+ oxidoreductase | None | None | |
| 1.3.1.8 | acyl-CoA dehydrogenase (NADP+) | False | 0 | 7 | 1 | 12 | acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ | acyl-CoA:NADP+ 2-oxidoreductase | None | 2-enoyl-CoA reductase; dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate); enoyl coenzyme A reductase; crotonyl coenzyme A reductase; crotonyl-CoA reductase; acyl-CoA dehydrogenase (NADP+) | |
| 1.3.1.9 | enoyl-[acyl-carrier-protein] reductase (NADH) | False | 150 | 35711 | 256 | 38 | an acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | acyl-[acyl-carrier protein]:NAD+ oxidoreductase | None | enoyl-[acyl carrier protein] reductase; enoyl-ACP reductase; NADH-enoyl acyl carrier protein reductase; NADH-specific enoyl-ACP reductase; acyl-[acyl-carrier-protein]:NAD+ oxidoreductase; fabI (gene name) | |
| 1.3.1.10 | enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) | False | 0 | 639 | 37 | 13 | an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ | acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Si-specific) | None | acyl-ACP dehydrogenase (ambiguous); enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADPH 2-enoyl Co A reductase; enoyl acyl-carrier-protein reductase (ambiguous); enoyl-ACP reductase (ambiguous); acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (B-specific); acyl-[acyl-carrier protein]:NADP+ oxidoreductase (B-specific); enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) | |
| 1.3.1.11 | 2-coumarate reductase | False | 0 | 1 | 0 | 1 | 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH + H+ | 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase | None | melilotate dehydrogenase | |
| 1.3.1.12 | prephenate dehydrogenase | False | 23 | 11802 | 7 | 32 | prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH | prephenate:NAD+ oxidoreductase (decarboxylating) | None | hydroxyphenylpyruvate synthase; chorismate mutase---prephenate dehydrogenase | |
| 1.3.1.13 | prephenate dehydrogenase (NADP+) | False | 2 | 1137 | 4 | 23 | prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH | prephenate:NADP+ oxidoreductase (decarboxylating) | None | prephenate dehydrogenase (ambiguous); prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; prephenate dehydrogenase (NADP) | |
| 1.3.1.14 | dihydroorotate dehydrogenase (NAD+) | False | 98 | 900 | 2 | 6 | (S)-dihydroorotate + NAD+ = orotate + NADH + H+ | (S)-dihydroorotate:NAD+ oxidoreductase | None | orotate reductase (NADH); orotate reductase (NADH2); DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase, pyrD (gene name) | |
| 1.3.1.15 | dihydroorotate dehydrogenase (NADP+) | False | 0 | 1 | 0 | 2 | (S)-dihydroorotate + NADP+ = orotate + NADPH + H+ | (S)-dihydroorotate:NADP+ oxidoreductase | None | orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH) | |
| 1.3.1.16 | beta-nitroacrylate reductase | True | 0 | 0 | 0 | 4 | 3-nitropropanoate + NADP+ = 3-nitroacrylate + NADPH + H+ | 3-nitropropanoate:NADP+ oxidoreductase | None | None | |
| 1.3.1.17 | 3-methyleneoxindole reductase | True | 0 | 0 | 0 | 11 | 3-methyl-1,3-dihydroindol-2-one + NADP+ = 3-methylene-1,3-dihydro-2H-indol-2-one + NADPH + H+ | 3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase | None | 3-methyloxindole:NADP+ oxidoreductase | |
| 1.3.1.18 | kynurenate-7,8-dihydrodiol dehydrogenase | True | 0 | 0 | 0 | 1 | 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + NADH + H+ | 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase | None | 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase; 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase | |
| 1.3.1.19 | cis-1,2-dihydrobenzene-1,2-diol dehydrogenase | False | 1 | 3 | 0 | 5 | cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+ | cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase | None | cis-benzene glycol dehydrogenase; cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase; | |
| 1.3.1.20 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | False | 17 | 1882 | 12 | 12 | trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase | None | dihydrodiol dehydrogenase | |
| 1.3.1.21 | 7-dehydrocholesterol reductase | False | 9 | 2738 | 0 | 12 | cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ | cholesterol:NADP+ Delta7-oxidoreductase | None | DHCR7 (gene name); 7-DHC reductase; 7-dehydrocholesterol dehydrogenase/cholesterol oxidase; Delta7-sterol reductase | |
| 1.3.1.22 | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) | False | 22 | 2314 | 1 | 19 | a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH + H+ | 3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase | None | cholestenone 5alpha-reductase; testosterone Delta4-5alpha-reductase; steroid 5alpha-reductase; 3-oxosteroid Delta4-dehydrogenase; 5alpha-reductase; steroid 5alpha-hydrogenase; 3-oxosteroid 5alpha-reductase; testosterone Delta4-hydrogenase; 4-ene-3-oxosteroid 5alpha-reductase; reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase; 4-ene-5alpha-reductase; Delta4-3-ketosteroid 5alpha-oxidoreductase; cholest-4-en-3-one 5alpha-reductase; testosterone 5alpha-reductase; 3-oxo-5alpha-steroid 4-dehydrogenase | |
| 1.3.1.24 | biliverdin reductase | False | 3 | 247 | 9 | 17 | bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ | bilirubin:NAD(P)+ oxidoreductase | None | None | |
| 1.3.1.25 | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | False | 2 | 1262 | 0 | 4 | (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+ | (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating) | None | 3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase; 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase; dihydrodihydroxybenzoate dehydrogenase; DHBDH; cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase; 2-hydro-1,2-dihydroxybenzoate dehydrogenase; cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase; dihydrodihydroxybenzoate dehydrogenase; (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating) | |
| 1.3.1.27 | 2-hexadecenal reductase | False | 0 | 1 | 0 | 6 | hexadecanal + NADP+ = 2-trans-hexadecenal + NADPH + H+ | hexadecanal:NADP+ Delta2-oxidoreductase | None | 2-alkenal reductase; hexadecanal: NADP+ oxidoreductase | |
| 1.3.1.28 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | False | 3 | 3596 | 1 | 4 | (2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+ | (2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase | None | 2,3-DHB dehydrogenase; 2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase | |
| 1.3.1.29 | cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase | False | 3 | 1 | 0 | 10 | (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+ | (1R,2S)-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase | None | (+)-cis-naphthalene dihydrodiol dehydrogenase; naphthalene dihydrodiol dehydrogenase; cis-dihydrodiol naphthalene dehydrogenase; cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase | |
| 1.3.1.31 | 2-enoate reductase | False | 2 | 153 | 0 | 43 | butanoate + NAD+ = but-2-enoate + NADH + H+ | butanoate:NAD+ Delta2-oxidoreductase | None | enoate reductase | |
| 1.3.1.32 | maleylacetate reductase | False | 10 | 447 | 2 | 20 | 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+ | 3-oxoadipate:NAD(P)+ oxidoreductase | None | maleolylacetate reductase | |
| 1.3.1.33 | protochlorophyllide reductase | False | 16 | 2222 | 6 | 53 | chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+ | chlorophyllide-a:NADP+ 7,8-oxidoreductase | None | NADPH2-protochlorophyllide oxidoreductase; NADPH-protochlorophyllide oxidoreductase; NADPH-protochlorophyllide reductase; protochlorophyllide oxidoreductase (ambiguous); protochlorophyllide photooxidoreductase; light-dependent protochlorophyllide reductase | |
| 1.3.1.34 | 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing] | False | 2 | 4317 | 6 | 7 | (1) a (2E)-2-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+;;(2) a (2E)-2-enoyl-CoA + NADP+ = a (2E,4Z)-2,4-dienoyl-CoA + NADPH + H+ | (2E)-2-enoyl-CoA:NADP+ 4-oxidoreductase | None | fadH (gene name); 4-enoyl-CoA reductase (NADPH) (ambiguous); 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase (ambiguous); 4-enoyl-CoA reductase (ambiguous); 2,4-dienoyl-CoA reductase (NADPH) (ambiguous); trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase | |
| 1.3.1.36 | geissoschizine dehydrogenase | False | 1 | 0 | 2 | 1 | geissoschizine + NADP+ = 4,21-didehydrogeissoschizine + NADPH | geissoschizine:NADP+ 4,21-oxidoreductase | None | None | |
| 1.3.1.37 | cis-2-enoyl-CoA reductase (NADPH) | True | 0 | 0 | 0 | 1 | acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH + H+ | acyl-CoA:NADP+ cis-2-oxidoreductase | None | NADPH-dependent cis-enoyl-CoA reductase; reductase, cis-2-enoyl coenzyme A; cis-2-enoyl-coenzyme A reductase; cis-2-enoyl-CoA reductase (NADPH) | |
| 1.3.1.38 | trans-2-enoyl-CoA reductase (NADPH) | False | 7 | 5835 | 2 | 11 | acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ | acyl-CoA:NADP+ trans-2-oxidoreductase | None | NADPH-dependent trans-2-enoyl-CoA reductase; reductase, trans-enoyl coenzyme A; trans-2-enoyl-CoA reductase (NADPH2) | |
| 1.3.1.39 | enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) | False | 7 | 1893 | 6 | 7 | an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ | acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific) | None | acyl-ACP dehydrogenase; enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADPH 2-enoyl Co A reductase; enoyl-ACp reductase; enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific); acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific); enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific); acyl-[acyl-carrier protein]:NADP+ oxidoreductase (A-specific) | |
| 1.3.1.40 | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase | True | 0 | 0 | 0 | 1 | 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+ | 2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase | None | 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase | |
| 1.3.1.41 | xanthommatin reductase | True | 0 | 0 | 0 | 1 | 5,12-dihydroxanthommatin + NAD+ = xanthommatin + NADH + H+ | 5,12-dihydroxanthommatin:NAD+ oxidoreductase | None | None | |
| 1.3.1.42 | 12-oxophytodienoate reductase | False | 7 | 298 | 32 | 27 | (9S,13S,15Z)-12-oxo-10,11-dihydrophyto-15-enoate + NADP+ = (9S,13S,15Z)-12-oxophyto-10,15-dienoate + NADPH + H+ | (9S,13S,15Z)-12-oxo-10,11-dihydrophyto-15-enoate:NADP+ 10-oxidoreductase | None | 12-oxo-phytodienoic acid reductase; 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase; (9S,13S)-10,11-dihydro-12-oxo-15-phytoenoate:NADP+ 4-oxidoreductase; (9S,13S)-12-oxophyto-15-enoate:NADP+ 10-oxidoreductase | |
| 1.3.1.43 | arogenate dehydrogenase | False | 1 | 909 | 1 | 22 | L-arogenate + NAD+ = L-tyrosine + NADH + CO2 | L-arogenate:NAD+ oxidoreductase (decarboxylating) | None | arogenic dehydrogenase (ambiguous); cyclohexadienyl dehydrogenase (ambiguous); pretyrosine dehydrogenase (ambiguous); L-arogenate:NAD+ oxidoreductase; arogenate dehydrogenase (NAD+) | |
| 1.3.1.44 | trans-2-enoyl-CoA reductase (NAD+) | False | 13 | 1254 | 1 | 9 | acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH + H+ | acyl-CoA:NAD+ trans-2-oxidoreductase | None | trans-2-enoyl-CoA reductase (NAD+) | |
| 1.3.1.45 | 2'-hydroxyisoflavone reductase | False | 4 | 117 | 0 | 11 | vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ | vestitone:NADP+ oxidoreductase | None | NADPH:2'-hydroxyisoflavone oxidoreductase; isoflavone reductase; 2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase | |
| 1.3.1.46 | biochanin-A reductase | True | 0 | 0 | 0 | 1 | dihydrobiochanin A + NADP+ = biochanin A + NADPH + H+ | dihydrobiochanin-A:NADP+ Delta2-oxidoreductase | None | None | |
| 1.3.1.47 | alpha-santonin 1,2-reductase | True | 0 | 0 | 0 | 1 | 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+ | 1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase | None | None | |
| 1.3.1.48 | 13,14-dehydro-15-oxoprostaglandin 13-reductase | False | 15 | 3325 | 11 | 8 | 11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ | 11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase | None | 15-oxo-Delta13-prostaglandin reductase; Delta13-15-ketoprostaglandin reductase; 15-ketoprostaglandin Delta13-reductase; prostaglandin Delta13-reductase; prostaglandin 13-reductase; (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase; (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Delta13-oxidoreductase | |
| 1.3.1.49 | cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase | False | 1 | 0 | 0 | 2 | (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ = phenanthrene-3,4-diol + NADH + H+ | (+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase | None | None | |
| 1.3.1.51 | 2'-hydroxydaidzein reductase | True | 0 | 0 | 0 | 1 | 2'-hydroxy-2,3-dihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+ | 2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase | None | NADPH:2'-hydroxydaidzein oxidoreductase; HDR; 2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase | |
| 1.3.1.53 | (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase | False | 2 | 12 | 0 | 1 | (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH | (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase | None | (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase; terephthalate 1,2-cis-dihydrodiol dehydrogenase; cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating) | |
| 1.3.1.54 | precorrin-6A reductase | False | 5 | 2830 | 3 | 3 | precorrin-6B + NADP+ = precorrin-6A + NADPH + H+ | precorrin-6B:NADP+ oxidoreductase | None | precorrin-6X reductase; precorrin-6Y:NADP+ oxidoreductase; CobK | |
| 1.3.1.56 | cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | False | 6 | 107 | 6 | 6 | cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+ | cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase | None | 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase | |
| 1.3.1.57 | phloroglucinol reductase | False | 1 | 0 | 0 | 4 | dihydrophloroglucinol + NADP+ = phloroglucinol + NADPH + H+ | dihydrophloroglucinol:NADP+ oxidoreductase | None | None | |
| 1.3.1.58 | 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase | False | 2 | 11 | 0 | 2 | cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+ | cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase | None | None | |
| 1.3.1.60 | dibenzothiophene dihydrodiol dehydrogenase | False | 2 | 1 | 0 | 2 | cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH + H+ | cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase | None | None | |
| 1.3.1.62 | pimeloyl-CoA dehydrogenase | False | 0 | 225 | 0 | 2 | pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+ | pimeloyl-CoA:NAD+ oxidoreductase | None | None | |
| 1.3.1.64 | phthalate 4,5-cis-dihydrodiol dehydrogenase | False | 0 | 27 | 0 | 1 | cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+ | cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase | None | None | |
| 1.3.1.65 | 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase | True | 0 | 0 | 0 | 1 | 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H+ | 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase | None | None | |
| 1.3.1.66 | cis-dihydroethylcatechol dehydrogenase | True | 0 | 0 | 0 | 1 | cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + NADH + H+ | cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase | None | None | |
| 1.3.1.67 | cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase | True | 0 | 0 | 0 | 1 | cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD(P)+ = 4-methylcatechol + NAD(P)H + CO2 | cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating) | None | None | |
| 1.3.1.68 | 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase | True | 0 | 0 | 0 | 1 | 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + CO2 | 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating) | None | None | |
| 1.3.1.69 | zeatin reductase | True | 0 | 0 | 0 | 2 | dihydrozeatin + NADP+ = zeatin + NADPH + H+ | dihydrozeatin:NADP+ oxidoreductase | None | None | |
| 1.3.1.70 | Delta14-sterol reductase | False | 20 | 1505 | 1 | 15 | 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase | None | None | |
| 1.3.1.71 | Delta24(241)-sterol reductase | False | 6 | 1996 | 0 | 4 | ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ | ergosterol:NADP+ Delta24(241)-oxidoreductase | None | sterol Delta24(28)-methylene reductase; sterol Delta24(28)-reductase | |
| 1.3.1.72 | Delta24-sterol reductase | False | 6 | 31 | 0 | 10 | 5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ | sterol:NADP+ Delta24-oxidoreductase | None | lanosterol Delta24-reductase | |
| 1.3.1.73 | 1,2-dihydrovomilenine reductase | True | 0 | 0 | 0 | 3 | 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+ | 17-O-acetylnorajmaline:NADP+ oxidoreductase | None | None | |
| 1.3.1.74 | 2-alkenal reductase [NAD(P)+] | False | 9 | 3536 | 5 | 6 | a n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H + H+ | n-alkanal:NAD(P)+ 2-oxidoreductase | None | NAD(P)H-dependent alkenal/one oxidoreductase; NADPH:2-alkenal alpha,beta-hydrogenase; 2-alkenal reductase | |
| 1.3.1.75 | 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) | False | 5 | 1138 | 0 | 12 | protochlorophyllide a + NADP+ = 3,8-divinyl protochlorophyllide a + NADPH + H+ | protochlorophyllide-a:NADP+ C-81-oxidoreductase | None | DVR (gene name); bciA (gene name); [4-vinyl]chlorophyllide a reductase; 4VCR; chlorophyllide-a:NADP+ oxidoreductase; divinyl chlorophyllide a 8-vinyl-reductase; plant-type divinyl chlorophyllide a 8-vinyl-reductase | |
| 1.3.1.76 | precorrin-2 dehydrogenase | False | 148 | 21147 | 1 | 5 | precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+ | precorrin-2:NAD+ oxidoreductase | None | Met8p; SirC; CysG | |
| 1.3.1.77 | anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming] | False | 1 | 38 | 2 | 30 | a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ | (2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase | None | ANR (gene name) (ambiguous); flavan-3-ol:NAD(P)+ oxidoreductase; anthocyanidin reductase (ambiguous) | |
| 1.3.1.78 | arogenate dehydrogenase (NADP+) | False | 2 | 64 | 0 | 22 | L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 | L-arogenate:NADP+ oxidoreductase (decarboxylating) | None | arogenic dehydrogenase (ambiguous); pretyrosine dehydrogenase (ambiguous); TyrAAT1; TyrAAT2; TyrAa | |
| 1.3.1.79 | arogenate dehydrogenase [NAD(P)+] | True | 0 | 0 | 0 | 12 | L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 | L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) | None | arogenic dehydrogenase (ambiguous); cyclohexadienyl dehydrogenase; pretyrosine dehydrogenase (ambiguous) | |
| 1.3.2.3 | L-galactonolactone dehydrogenase | False | 4 | 39 | 5 | 22 | L-galactono-1,4-lactone + 4 ferricytochrome c = L-dehydroascorbate + 4 ferrocytochrome c + 4 H+ (overall reaction);;(1a) L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c + 2 H+;;(1b) L-ascorbate + 2 ferricytochrome c = L-dehydroascorbate + 2 ferrocytochrome c + 2 H+ (spontaneous) | L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase | None | galactonolactone dehydrogenase; L-galactono-gamma-lactone dehydrogenase; L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase; GLDHase; GLDase | |
| 1.3.3.3 | coproporphyrinogen oxidase | False | 240 | 21596 | 12 | 26 | coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O | coproporphyrinogen:oxygen oxidoreductase (decarboxylating) | None | coproporphyrinogen III oxidase; coproporphyrinogenase | |
| 1.3.3.4 | protoporphyrinogen oxidase | False | 15 | 5211 | 7 | 48 | protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 | protoporphyrinogen-IX:oxygen oxidoreductase | None | protoporphyrinogen IX oxidase; protoporphyrinogenase; PPO; Protox; HemG; HemY | |
| 1.3.3.5 | bilirubin oxidase | False | 2 | 144 | 8 | 14 | 2 bilirubin + O2 = 2 biliverdin + 2 H2O | bilirubin:oxygen oxidoreductase | None | bilirubin oxidase M-1 | |
| 1.3.3.6 | acyl-CoA oxidase | False | 36 | 985 | 10 | 40 | acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 | acyl-CoA:oxygen 2-oxidoreductase | None | fatty acyl-CoA oxidase; acyl coenzyme A oxidase; fatty acyl-coenzyme A oxidase | |
| 1.3.3.7 | dihydrouracil oxidase | True | 0 | 0 | 0 | 1 | 5,6-dihydrouracil + O2 = uracil + H2O2 | 5,6-dihydrouracil:oxygen oxidoreductase | None | None | |
| 1.3.3.8 | tetrahydroberberine oxidase | False | 2 | 113 | 0 | 9 | (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2 | (S)-tetrahydroberberine:oxygen oxidoreductase | None | (S)-THB oxidase | |
| 1.3.3.10 | tryptophan alpha,beta-oxidase | True | 0 | 0 | 0 | 3 | L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 | L-tryptophan:oxygen alpha,beta-oxidoreductase | None | L-tryptophan 2',3'-oxidase; L-tryptophan alpha,beta-dehydrogenase | |
| 1.3.3.11 | pyrroloquinoline-quinone synthase | False | 50 | 5138 | 11 | 9 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) | None | PqqC; 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) [incorrect] | |
| 1.3.5.1 | succinate dehydrogenase | False | 98 | 66719 | 61 | 75 | succinate + a quinone = fumarate + a quinol | succinate:quinone oxidoreductase | None | succinate dehydrogenase (quinone); succinate dehydrogenase (ubiquinone); succinic dehydrogenase; complex II (ambiguous); succinate dehydrogenase complex; SDH (ambiguous); succinate:ubiquinone oxidoreductase; fumarate reductase (quinol); FRD; menaquinol-fumarate oxidoreductase; succinate dehydrogenase (menaquinone); succinate:menaquinone oxidoreductase; fumarate reductase (menaquinone) | |
| 1.3.7.1 | 6-hydroxynicotinate reductase | False | 1 | 94 | 0 | 3 | 6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin | 6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase | None | 6-oxotetrahydronicotinate dehydrogenase; 6-hydroxynicotinic reductase; HNA reductase; 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase | |
| 1.3.7.2 | 15,16-dihydrobiliverdin:ferredoxin oxidoreductase | False | 19 | 267 | 1 | 6 | 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXalpha + reduced ferredoxin | 15,16-dihydrobiliverdin:ferredoxin oxidoreductase | None | PebA | |
| 1.3.7.3 | phycoerythrobilin:ferredoxin oxidoreductase | False | 20 | 345 | 0 | 5 | (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin | (3Z)-phycoerythrobilin:ferredoxin oxidoreductase | None | PebB | |
| 1.3.7.4 | phytochromobilin:ferredoxin oxidoreductase | False | 1 | 16 | 2 | 6 | (3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin | (3Z)-phytochromobilin:ferredoxin oxidoreductase | None | HY2; PPhi B synthase; phytochromobilin synthase | |
| 1.3.7.5 | phycocyanobilin:ferredoxin oxidoreductase | False | 25 | 784 | 20 | 10 | (3Z)-phycocyanobilin + 4 oxidized ferredoxin = biliverdin IXalpha + 4 reduced ferredoxin | (3Z)-phycocyanobilin:ferredoxin oxidoreductase | None | None | |
| 1.3.99.4 | 3-oxosteroid 1-dehydrogenase | False | 5 | 1325 | 7 | 21 | a 3-oxosteroid + acceptor = a 3-oxo-Delta1-steroid + reduced acceptor | 3-oxosteroid:acceptor Delta1-oxidoreductase | None | 3-oxosteroid Delta1-dehydrogenase; Delta1-dehydrogenase; 3-ketosteroid-1-en-dehydrogenase; 3-ketosteroid-Delta1-dehydrogenase; 1-ene-dehydrogenase; 3-oxosteroid:(2,6-dichlorphenolindophenol) Delta1-oxidoreductase; 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase; Delta1-steroid reductase; 3-oxosteroid:(acceptor) Delta1-oxidoreductase | |
| 1.3.99.5 | 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) | False | 1 | 198 | 2 | 11 | a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-Delta4-steroid + reduced acceptor | 3-oxo-5alpha-steroid:acceptor Delta4-oxidoreductase | None | steroid 5alpha-reductase; 3-oxosteroid Delta4-dehydrogenase; 3-oxo-5alpha-steroid Delta4-dehydrogenase; steroid Delta4-5alpha-reductase; Delta4-3-keto steroid 5alpha-reductase; Delta4-3-oxo steroid reductase; Delta4-3-ketosteroid5alpha-oxidoreductase; Delta4-3-oxosteroid-5alpha-reductase; 3-keto-Delta4-steroid-5alpha-reductase; 5alpha-reductase; testosterone 5alpha-reductase; 4-ene-3-ketosteroid-5alpha-oxidoreductase; Delta4-5alpha-dehydrogenase; 3-oxo-5alpha-steroid:(acceptor) Delta4-oxidoreductase; tesI (gene name) | |
| 1.3.99.6 | 3-oxo-5beta-steroid 4-dehydrogenase | False | 0 | 67 | 0 | 5 | a 3-oxo-5beta-steroid + acceptor = a 3-oxo-Delta4-steroid + reduced acceptor | 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase | None | 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase | |
| 1.3.99.8 | 2-furoyl-CoA dehydrogenase | False | 0 | 88 | 0 | 1 | 2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor | 2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating) | None | furoyl-CoA hydroxylase; 2-furoyl coenzyme A hydroxylase; 2-furoyl coenzyme A dehydrogenase; 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating) | |
| 1.3.99.14 | cyclohexanone dehydrogenase | True | 0 | 0 | 0 | 1 | cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor | cyclohexanone:acceptor 2-oxidoreductase | None | cyclohexanone:(acceptor) 2-oxidoreductase | |
| 1.3.99.16 | isoquinoline 1-oxidoreductase | False | 2 | 3086 | 0 | 1 | isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor | isoquinoline:acceptor 1-oxidoreductase (hydroxylating) | None | None | |
| 1.3.99.17 | quinoline 2-oxidoreductase | False | 3 | 0 | 1 | 3 | quinoline + acceptor + H2O = quinolin-2(1H)-one + reduced acceptor | quinoline:acceptor 2-oxidoreductase (hydroxylating) | None | None | |
| 1.3.99.18 | quinaldate 4-oxidoreductase | True | 0 | 0 | 0 | 2 | quinaldate + acceptor + H2O = kynurenate + reduced acceptor | quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating) | None | quinaldic acid 4-oxidoreductase | |
| 1.3.99.19 | quinoline-4-carboxylate 2-oxidoreductase | True | 0 | 0 | 0 | 1 | quinoline-4-carboxylate + acceptor + H2O = 2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced acceptor | quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating) | None | quinaldic acid 4-oxidoreductase; quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating) | |
| 1.3.99.23 | all-trans-retinol 13,14-reductase | False | 5 | 1061 | 0 | 4 | all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor | all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase | None | retinol saturase; RetSat; (13,14)-all-trans-retinol saturase; all-trans-retinol:all-trans-13,14-dihydroretinol saturase | |
| 1.4.1.1 | alanine dehydrogenase | False | 34 | 27759 | 16 | 72 | L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+ | L-alanine:NAD+ oxidoreductase (deaminating) | None | AlaDH; L-alanine dehydrogenase; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alanine dehydrogenase | |
| 1.4.1.2 | glutamate dehydrogenase | False | 26 | 3368 | 17 | 95 | L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+ | L-glutamate:NAD+ oxidoreductase (deaminating) | None | glutamic dehydrogenase; glutamate dehydrogenase (NAD+); glutamate oxidoreductase; glutamic acid dehydrogenase; L-glutamate dehydrogenase; NAD+-dependent glutamate dehydrogenase; NAD+-dependent glutamic dehydrogenase; NAD+-glutamate dehydrogenase; NAD+-linked glutamate dehydrogenase; NAD+-linked glutamic dehydrogenase; NAD+-specific glutamic dehydrogenase; NAD+-specific glutamate dehydrogenase; NAD+:glutamate oxidoreductase; NADH-linked glutamate dehydrogenase | |
| 1.4.1.3 | glutamate dehydrogenase [NAD(P)+] | False | 43 | 2412 | 69 | 48 | L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ | L-glutamate:NAD(P)+ oxidoreductase (deaminating) | None | glutamic dehydrogenase; glutamate dehydrogenase [NAD(P)+] | |
| 1.4.1.4 | glutamate dehydrogenase (NADP+) | False | 33 | 3590 | 5 | 88 | L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+ | L-glutamate:NADP+ oxidoreductase (deaminating) | None | glutamic dehydrogenase; dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)); glutamic acid dehydrogenase; L-glutamate dehydrogenase; L-glutamic acid dehydrogenase; NAD(P)+-glutamate dehydrogenase; NAD(P)H-dependent glutamate dehydrogenase; glutamate dehydrogenase (NADP+) | |
| 1.4.1.5 | L-amino-acid dehydrogenase | False | 0 | 1 | 0 | 5 | an L-amino acid + H2O + NAD+ = a 2-oxo carboxylate + NH3 + NADH + H+ | L-amino-acid:NAD+ oxidoreductase (deaminating) | None | None | |
| 1.4.1.7 | serine 2-dehydrogenase | True | 0 | 0 | 0 | 2 | L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH + H+ | L-serine:NAD+ 2-oxidoreductase (deaminating) | None | L-serine:NAD+ oxidoreductase (deaminating); serine dehydrogenase | |
| 1.4.1.8 | valine dehydrogenase (NADP+) | False | 0 | 14 | 0 | 14 | L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH + H+ | L-valine:NADP+ oxidoreductase (deaminating) | None | valine dehydrogenase (nicotinanide adenine dinucleotide phosphate); valine dehydrogenase (NADP) | |
| 1.4.1.9 | leucine dehydrogenase | False | 6 | 1049 | 5 | 23 | L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ | L-leucine:NAD+ oxidoreductase (deaminating) | None | L-leucine dehydrogenase; L-leucine:NAD+ oxidoreductase, deaminating; LeuDH | |
| 1.4.1.10 | glycine dehydrogenase | True | 0 | 0 | 0 | 8 | glycine + H2O + NAD+ = glyoxylate + NH3 + NADH + H+ | glycine:NAD+ oxidoreductase (deaminating) | None | None | |
| 1.4.1.11 | L-erythro-3,5-diaminohexanoate dehydrogenase | False | 2 | 159 | 4 | 2 | L-erythro-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxohexanoate + NH3 + NADH + H+ | L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating) | None | L-3,5-diaminohexanoate dehydrogenase | |
| 1.4.1.12 | 2,4-diaminopentanoate dehydrogenase | False | 1 | 88 | 0 | 3 | (2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ | (2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating) | None | 2,4-diaminopentanoic acid C4 dehydrogenase | |
| 1.4.1.13 | glutamate synthase (NADPH) | False | 18 | 31584 | 6 | 27 | 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+ (overall reaction);;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+ | L-glutamate:NADP+ oxidoreductase (transaminating) | None | glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase; L-glutamate synthase; L-glutamate synthetase; glutamate synthetase (NADP); NADPH-dependent glutamate synthase; glutamine-ketoglutaric aminotransferase; NADPH-glutamate synthase; NADPH-linked glutamate synthase; glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP); L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing; GOGAT | |
| 1.4.1.14 | glutamate synthase (NADH) | False | 6 | 4688 | 0 | 34 | 2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+;;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + NAD+ + H2O = NH3 + 2-oxoglutarate + NADH + H+ | L-glutamate:NAD+ oxidoreductase (transaminating) | None | glutamate (reduced nicotinamide adenine dinucleotide) synthase; NADH: GOGAT; L-glutamate synthase (NADH); L-glutamate synthetase; NADH-glutamate synthase; NADH-dependent glutamate synthase | |
| 1.4.1.15 | lysine dehydrogenase | True | 0 | 0 | 0 | 15 | L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+ | L-lysine:NAD+ oxidoreductase (deaminating, cyclizing) | None | None | |
| 1.4.1.16 | diaminopimelate dehydrogenase | False | 5 | 3713 | 20 | 46 | meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ | meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating) | None | meso-alpha,epsilon-diaminopimelate dehydrogenase; meso-diaminopimelate dehydrogenase | |
| 1.4.1.17 | N-methylalanine dehydrogenase | False | 2 | 1 | 0 | 1 | N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH + H+ | N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating) | None | None | |
| 1.4.1.18 | lysine 6-dehydrogenase | False | 1 | 261 | 1 | 16 | L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction);;(1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3;;(1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) | L-lysine:NAD+ 6-oxidoreductase (deaminating) | None | L-lysine epsilon-dehydrogenase; L-lysine 6-dehydrogenase; LysDH | |
| 1.4.1.19 | tryptophan dehydrogenase | False | 2 | 40 | 1 | 7 | L-tryptophan + NAD(P)+ + H2O = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+ | L-tryptophan:NAD(P)+ oxidoreductase (deaminating) | None | NAD(P)+-L-tryptophan dehydrogenase; L-tryptophan dehydrogenase; L-Trp-dehydrogenase; TDH | |
| 1.4.1.20 | phenylalanine dehydrogenase | False | 8 | 34 | 2 | 13 | L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ | L-phenylalanine:NAD+ oxidoreductase (deaminating) | None | L-phenylalanine dehydrogenase; PHD | |
| 1.4.1.21 | aspartate dehydrogenase | False | 53 | 4959 | 1 | 9 | L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ (overall reaction);;(1a) L-aspartate + NAD(P)+ = 2-iminosuccinate + NAD(P)H + H+;;(1b) 2-iminosuccinate + H2O = oxaloacetate + NH3 (spontaneous) | L-aspartate:NAD(P)+ oxidoreductase (2-iminosuccinate-forming) | None | AspDH; NAD-dependent aspartate dehydrogenase; NADH2-dependent aspartate dehydrogenase; NADP+-dependent aspartate dehydrogenase; nadX (gene name); L-aspartate:NAD(P)+ oxidoreductase (deaminating) | |
| 1.4.2.1 | glycine dehydrogenase (cytochrome) | True | 0 | 0 | 0 | 1 | glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c + 2 H+ | glycine:ferricytochrome-c oxidoreductase (deaminating) | None | glycine---cytochrome c reductase | |
| 1.4.3.1 | D-aspartate oxidase | False | 16 | 1323 | 1 | 40 | D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2 | D-aspartate:oxygen oxidoreductase (deaminating) | None | aspartic oxidase; D-aspartic oxidase | |
| 1.4.3.2 | L-amino-acid oxidase | False | 67 | 1084 | 19 | 106 | an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 | L-amino-acid:oxygen oxidoreductase (deaminating) | None | ophio-amino-acid oxidase (ambiguous) | |
| 1.4.3.3 | D-amino-acid oxidase | False | 31 | 4913 | 38 | 55 | a D-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 | D-amino-acid:oxygen oxidoreductase (deaminating) | None | ophio-amino-acid oxidase (ambiguous); L-amino acid:O2 oxidoreductase; new yellow enzyme | |
| 1.4.3.4 | monoamine oxidase | False | 23 | 1809 | 68 | 65 | RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 | amine:oxygen oxidoreductase (deaminating) | None | adrenalin oxidase; adrenaline oxidase; amine oxidase (ambiguous); amine oxidase (flavin-containing); amine:oxygen oxidoreductase (deaminating) (flavin-containing); epinephrine oxidase; MAO; MAO A; MAO B; MAO-A; MAO-B; monoamine oxidase A; monoamine oxidase B; monoamine:O2 oxidoreductase (deaminating); polyamine oxidase (ambiguous); serotonin deaminase; spermidine oxidase (ambiguous); spermine oxidase (ambiguous); tyraminase; tyramine oxidase | |
| 1.4.3.5 | pyridoxal 5'-phosphate synthase | False | 359 | 28074 | 21 | 39 | (1) pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2;;(2) pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2 | pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating) | None | pyridoxamine 5'-phosphate oxidase; pyridoxamine phosphate oxidase; pyridoxine (pyridoxamine)phosphate oxidase; pyridoxine (pyridoxamine) 5'-phosphate oxidase; pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating); PMP oxidase; pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) (incorrect); pyridoxamine-phosphate oxidase; PdxH | |
| 1.4.3.7 | D-glutamate oxidase | True | 0 | 0 | 0 | 2 | D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2 | D-glutamate:oxygen oxidoreductase (deaminating) | None | D-glutamic oxidase; D-glutamic acid oxidase | |
| 1.4.3.8 | ethanolamine oxidase | False | 0 | 2 | 0 | 3 | ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2 | ethanolamine:oxygen oxidoreductase (deaminating) | None | None | |
| 1.4.3.10 | putrescine oxidase | False | 1 | 358 | 6 | 14 | putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2 | putrescine:oxygen oxidoreductase (deaminating) | None | None | |
| 1.4.3.11 | L-glutamate oxidase | False | 3 | 3 | 3 | 7 | L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2 | L-glutamate:oxygen oxidoreductase (deaminating) | None | glutamate (acceptor) dehydrogenase; glutamate oxidase; glutamic acid oxidase; glutamic dehydrogenase (acceptor); L-glutamic acid oxidase | |
| 1.4.3.12 | cyclohexylamine oxidase | True | 0 | 0 | 0 | 3 | cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + H2O2 | cyclohexylamine:oxygen oxidoreductase (deaminating) | None | None | |
| 1.4.3.13 | protein-lysine 6-oxidase | False | 26 | 6271 | 4 | 14 | [protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | protein-L-lysine:oxygen 6-oxidoreductase (deaminating) | None | lysyl oxidase | |
| 1.4.3.14 | L-lysine oxidase | False | 0 | 1 | 5 | 11 | L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2 | L-lysine:oxygen 2-oxidoreductase (deaminating) | None | L-lysine alpha-oxidase; L-lysyl-alpha-oxidase | |
| 1.4.3.15 | D-glutamate(D-aspartate) oxidase | True | 0 | 0 | 0 | 3 | (1) D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2;;(2) D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2 | D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating) | None | D-glutamic-aspartic oxidase; D-monoaminodicarboxylic acid oxidase | |
| 1.4.3.16 | L-aspartate oxidase | False | 43 | 30226 | 5 | 7 | L-aspartate + O2 = iminosuccinate + H2O2 | L-aspartate:oxygen oxidoreductase | None | NadB; Laspo; AO | |
| 1.4.3.19 | glycine oxidase | False | 8 | 4996 | 3 | 6 | glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (overall reaction);;(1a) glycine + O2 = 2-iminoacetate + H2O2;;(1b) 2-iminoacetate + H2O = glyoxylate + NH3 | glycine:oxygen oxidoreductase (deaminating) | None | None | |
| 1.4.4.2 | glycine dehydrogenase (aminomethyl-transferring) | False | 537 | 52582 | 11 | 22 | glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2 | glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) | None | P-protein; glycine decarboxylase; glycine-cleavage complex; glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating); protein P1; glycine dehydrogenase (decarboxylating); glycine cleavage system P-protein; glycine-cleavage complex P-protein | |
| 1.4.7.1 | glutamate synthase (ferredoxin) | False | 12 | 3630 | 5 | 28 | 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+ (overall reaction);;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+ | L-glutamate:ferredoxin oxidoreductase (transaminating) | None | ferredoxin-dependent glutamate synthase; ferredoxin-glutamate synthase; glutamate synthase (ferredoxin-dependent) | |
| 1.4.99.2 | taurine dehydrogenase | False | 0 | 9 | 0 | 12 | taurine + H2O + acceptor = 2-sulfoacetaldehyde + NH3 + reduced acceptor | taurine:acceptor oxidoreductase (deaminating) | None | taurine:(acceptor) oxidoreductase (deaminating) | |
| 1.4.99.5 | glycine dehydrogenase (cyanide-forming) | False | 6 | 1362 | 0 | 9 | glycine + 2 acceptor = hydrogen cyanide + CO2 + 2 reduced acceptor | glycine:acceptor oxidoreductase (hydrogen-cyanide-forming) | None | hydrogen cyanide synthase; HCN synthase | |
| 1.5.1.1 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] | False | 1 | 37 | 0 | 13 | (1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+;; (2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ | L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase | None | Delta1-pyrroline-2-carboxylate reductase; DELTA1-pyrroline-2-carboxylate reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); AbLhpI; pyrroline-2-carboxylate reductase; L-proline:NAD(P)+ 2-oxidoreductase | |
| 1.5.1.2 | pyrroline-5-carboxylate reductase | False | 63 | 46809 | 44 | 42 | L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ | L-proline:NAD(P)+ 5-oxidoreductase | None | proline oxidase; L-proline oxidase; 1-pyrroline-5-carboxylate reductase; NADPH-L-Delta1-pyrroline carboxylic acid reductase; L-proline-NAD(P)+ 5-oxidoreductase | |
| 1.5.1.3 | dihydrofolate reductase | False | 118 | 41783 | 583 | 81 | 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase | None | tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase | |
| 1.5.1.5 | methylenetetrahydrofolate dehydrogenase (NADP+) | False | 818 | 46185 | 28 | 22 | 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+ | 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase | None | N5,N10-methylenetetrahydrofolate dehydrogenase; 5,10-methylenetetrahydrofolate:NADP oxidoreductase; 5,10-methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP) | |
| 1.5.1.6 | formyltetrahydrofolate dehydrogenase | False | 8 | 2186 | 19 | 7 | 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ | 10-formyltetrahydrofolate:NADP+ oxidoreductase | None | 10-formyl tetrahydrofolate:NADP oxidoreductase; 10-formyl-H2PtGlu:NADP oxidoreductase; 10-formyl-H4folate dehydrogenase; N10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogenase | |
| 1.5.1.7 | saccharopine dehydrogenase (NAD+, L-lysine-forming) | False | 8 | 4362 | 10 | 6 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ | N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming) | None | lysine-2-oxoglutarate reductase; dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming); epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming); N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming); 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming) | |
| 1.5.1.8 | saccharopine dehydrogenase (NADP+, L-lysine-forming) | False | 5 | 66 | 9 | 25 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+ | N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) | None | lysine-2-oxoglutarate reductase; lysine-ketoglutarate reductase; L-lysine-alpha-ketoglutarate reductase; lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming); saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase; 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) | |
| 1.5.1.9 | saccharopine dehydrogenase (NAD+, L-glutamate-forming) | False | 5 | 131 | 0 | 22 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ | N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) | None | dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming); saccharopin dehydrogenase; NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming); aminoadipic semialdehyde synthase; 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) | |
| 1.5.1.10 | saccharopine dehydrogenase (NADP+, L-glutamate-forming) | False | 4 | 105 | 3 | 10 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ | N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming) | None | saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase; aminoadipic semialdehyde-glutamic reductase; aminoadipate semialdehyde-glutamate reductase; aminoadipic semialdehyde-glutamate reductase; epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming); saccharopine reductase; 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming) | |
| 1.5.1.11 | D-octopine dehydrogenase | False | 5 | 32 | 4 | 57 | N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH + H+ | N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming) | None | D-octopine synthase; octopine dehydrogenase; octopine:NAD+ oxidoreductase; ODH; 2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming) | |
| 1.5.1.15 | methylenetetrahydrofolate dehydrogenase (NAD+) | False | 12 | 80 | 14 | 17 | 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+ | 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase | None | None | |
| 1.5.1.16 | D-lysopine dehydrogenase | False | 3 | 1 | 0 | 6 | N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH + H+ | N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) | None | D-lysopine synthase; lysopine dehydrogenase; D(+)-lysopine dehydrogenase; 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) | |
| 1.5.1.17 | alanopine dehydrogenase | False | 0 | 4 | 0 | 66 | 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+ | 2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming) | None | ALPDH; alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase; meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase; alanopine: NAD+ oxidoreductase; ADH (ambiguous); alanopine:NAD+ oxidoreductase | |
| 1.5.1.18 | ephedrine dehydrogenase | True | 0 | 0 | 0 | 1 | (-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+ | (-)-ephedrine:NAD+ 2-oxidoreductase | None | None | |
| 1.5.1.19 | D-nopaline dehydrogenase | False | 2 | 8 | 0 | 3 | N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH + H+ | N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming) | None | D-nopaline synthase; nopaline dehydrogenase; nopaline synthase; NOS; 2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming) | |
| 1.5.1.20 | methylenetetrahydrofolate reductase [NAD(P)H] | False | 3 | 2761 | 17 | 67 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ | 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase | None | MTHFR (gene name) | |
| 1.5.1.53 | methylenetetrahydrofolate reductase (NADPH) | False | 7 | 1451 | 0 | 4 | 5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+ | 5-methyltetrahydrofolate:NADP+ oxidoreductase | None | MTHFR (gene name); methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase; 5,10-methylenetetrahydrofolate reductase (NADPH); 5,10-methylenetetrahydrofolic acid reductase (ambiguous); 5,10-CH2-H4folate reductase (ambiguous); methylenetetrahydrofolate reductase (NADPH2); 5,10-methylenetetrahydrofolate reductase (ambiguous); methylenetetrahydrofolate reductase (ambiguous); N5,10-methylenetetrahydrofolate reductase (ambiguous); 5,10-methylenetetrahydropteroylglutamate reductase (ambiguous); N5,N10-methylenetetrahydrofolate reductase (ambiguous); methylenetetrahydrofolic acid reductase (ambiguous); 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect); 5,10-methylenetetrahydrofolate reductase (FADH2) (ambiguous) | |
| 1.5.1.21 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) | False | 3 | 123 | 1 | 12 | (1) L-pipecolate + NADP+ = 1-piperideine-2-carboxylate + NADPH + H+;; (2) L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ | L-pipecolate/L-proline:NADP+ 2-oxidoreductase | None | Pyr2C reductase; 1,2-didehydropipecolate reductase; P2C reductase; 1,2-didehydropipecolic reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); L-pipecolate:NADP+ 2-oxidoreductase; DELTA1-piperideine-2-carboxylate reductase; Delta1-piperideine-2-carboxylate reductase | |
| 1.5.1.22 | strombine dehydrogenase | False | 0 | 5 | 0 | 37 | N-(carboxymethyl)-D-alanine + NAD+ + H2O = glycine + pyruvate + NADH + H+ | N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming) | None | strombine[N-(carboxymethyl)-D-alanine]dehydrogenase; N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase | |
| 1.5.1.23 | tauropine dehydrogenase | False | 1 | 0 | 0 | 44 | tauropine + NAD+ + H2O = taurine + pyruvate + NADH + H+ | N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming) | None | 2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming) | |
| 1.5.1.24 | N5-(carboxyethyl)ornithine synthase | False | 3 | 59 | 0 | 2 | N5-(L-1-carboxyethyl)-L-ornithine + NADP+ + H2O = L-ornithine + pyruvate + NADPH + H+ | N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming) | None | 5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming) | |
| 1.5.1.25 | thiomorpholine-carboxylate dehydrogenase | False | 5 | 1239 | 3 | 6 | thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ | thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase | None | ketimine reductase; ketimine-reducing enzyme | |
| 1.5.1.26 | beta-alanopine dehydrogenase | True | 0 | 0 | 0 | 34 | beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH + H+ | N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming) | None | None | |
| 1.5.1.27 | 1,2-dehydroreticulinium reductase (NADPH) | False | 1 | 0 | 0 | 3 | (R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+ | (R)-reticuline:NADP+ oxidoreductase | None | 1,2-dehydroreticulinium ion reductase | |
| 1.5.1.28 | opine dehydrogenase | False | 1 | 284 | 0 | 4 | (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate + NAD+ + H2O = L-2-aminopentanoic acid + pyruvate + NADH + H+ | (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming) | None | (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming) | |
| 1.5.1.30 | flavin reductase (NADPH) | False | 5 | 247 | 20 | 16 | reduced riboflavin + NADP+ = riboflavin + NADPH + H+ | reduced-riboflavin:NADP+ oxidoreductase | None | NADPH:flavin oxidoreductase; riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase; flavin mononucleotide reductase; flavine mononucleotide reductase; FMN reductase (NADPH); NADPH-dependent FMN reductase; NADPH-flavin reductase; NADPH-FMN reductase; NADPH-specific FMN reductase; riboflavin mononucleotide reductase; riboflavine mononucleotide reductase; NADPH2 dehydrogenase (flavin); NADPH2:riboflavin oxidoreductase | |
| 1.5.1.31 | berberine reductase | True | 0 | 0 | 0 | 2 | (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+ | (R)-tetrahydroberberine:NADP+ oxidoreductase | None | (R)-canadine synthase | |
| 1.5.1.32 | vomilenine reductase | False | 0 | 2 | 0 | 1 | 1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+ | 1,2-dihydrovomilenine:NADP+ oxidoreductase | None | None | |
| 1.5.1.33 | pteridine reductase | False | 2 | 1098 | 58 | 10 | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ | 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase | None | PTR1; pteridine reductase 1 | |
| 1.5.1.34 | 6,7-dihydropteridine reductase | False | 7 | 2262 | 14 | 18 | a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+ | 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase | None | 6,7-dihydropteridine:NAD(P)H oxidoreductase; DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase; NADH-dihydropteridine reductase; NADPH-dihydropteridine reductase; NADPH-specific dihydropteridine reductase; dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase; dihydropteridine reductase; dihydropteridine reductase (NADH); 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase | |
| 1.5.3.1 | sarcosine oxidase (formaldehyde-forming) | False | 11 | 5759 | 27 | 14 | sarcosine + H2O + O2 = glycine + formaldehyde + H2O2 | sarcosine:oxygen oxidoreductase (demethylating) | None | MSOX; monomeric sarcosine oxidase; sarcosine oxidase (ambiguous) | |
| 1.5.3.2 | N-methyl-L-amino-acid oxidase | False | 0 | 1601 | 0 | 1 | an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2 | N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating) | None | N-methylamino acid oxidase; demethylase | |
| 1.5.3.4 | N6-methyl-lysine oxidase | False | 0 | 3 | 0 | 9 | N6-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2 | N6-methyl-L-lysine:oxygen oxidoreductase (demethylating) | None | epsilon-alkyl-L-lysine:oxygen oxidoreductase ; N6-methyllysine oxidase; epsilon-N-methyllysine demethylase; epsilon-alkyllysinase; 6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating) | |
| 1.5.3.5 | (S)-6-hydroxynicotine oxidase | False | 2 | 1 | 13 | 4 | (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 (overall reaction);;(1a) (S)-6-hydroxynicotine + O2 = 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O2;;(1b) 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one (spontaneous) | (S)-6-hydroxynicotine:oxygen oxidoreductase | None | L-6-hydroxynicotine oxidase; 6-hydroxy-L-nicotine oxidase; 6-hydroxy-L-nicotine:oxygen oxidoreductase; nctB (gene name) | |
| 1.5.3.6 | (R)-6-hydroxynicotine oxidase | False | 1 | 255 | 3 | 1 | (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 (overall reaction);;(1a) (R)-6-hydroxynicotine + O2 = 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O2 ;;(1b) 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one (spontaneous) | (R)-6-hydroxynicotine:oxygen oxidoreductase | None | D-6-hydroxynicotine oxidase; 6-hydroxy-D-nicotine oxidase | |
| 1.5.3.7 | L-pipecolate oxidase | False | 7 | 31 | 0 | 9 | L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | L-pipecolate:oxygen 1,6-oxidoreductase | None | pipecolate oxidase; L-pipecolic acid oxidase | |
| 1.5.3.10 | dimethylglycine oxidase | False | 1 | 57 | 4 | 2 | N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + O2 = sarcosine + 5,10-methylenetetrahydrofolate + H2O2 | N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:oxygen oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming) | None | dmg (gene name); N,N-dimethylglycine:oxygen oxidoreductase (demethylating) | |
| 1.5.3.12 | dihydrobenzophenanthridine oxidase | True | 0 | 0 | 0 | 4 | (1) dihydrosanguinarine + O2 = sanguinarine + H2O2;;(2) dihydrochelirubine + O2 = chelirubine + H2O2;;(3) dihydromacarpine + O2 = macarpine + H2O2 | dihydrobenzophenanthridine:oxygen oxidoreductase | None | None | |
| 1.5.4.1 | pyrimidodiazepine synthase | False | 1 | 0 | 0 | 1 | 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione | 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing) | None | PDA synthase; pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing); pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing) | |
| 1.5.5.1 | electron-transferring-flavoprotein dehydrogenase | False | 15 | 19567 | 2 | 14 | reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol | electron-transferring-flavoprotein:ubiquinone oxidoreductase | None | ETF-QO; ETF:ubiquinone oxidoreductase; electron transfer flavoprotein dehydrogenase; electron transfer flavoprotein Q oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase; electron transfer flavoprotein reductase | |
| 1.5.7.1 | methylenetetrahydrofolate reductase (ferredoxin) | False | 0 | 2 | 0 | 2 | 5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+ | 5-methyltetrahydrofolate:ferredoxin oxidoreductase | None | 5,10-methylenetetrahydrofolate reductase | |
| 1.5.8.1 | dimethylamine dehydrogenase | False | 1 | 42 | 0 | 3 | dimethylamine + H2O + electron-transfer flavoprotein = methylamine + formaldehyde + reduced electron-transfer flavoprotein | dimethylamine:electron-transfer flavoprotein oxidoreductase | None | None | |
| 1.5.8.2 | trimethylamine dehydrogenase | False | 1 | 143 | 0 | 6 | trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein | trimethylamine:electron-transfer flavoprotein oxidoreductase (demethylating) | None | None | |
| 1.5.99.3 | L-pipecolate dehydrogenase | False | 0 | 3 | 0 | 1 | L-pipecolate + acceptor = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor | L-pipecolate:acceptor 1,6-oxidoreductase | None | L-pipecolate:(acceptor) 1,6-oxidoreductase | |
| 1.5.99.4 | nicotine 6-hydroxylase | False | 3 | 8 | 0 | 10 | (S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor | nicotine:acceptor 6-oxidoreductase (hydroxylating) | None | nicotine oxidase; D-nicotine oxidase; nicotine:(acceptor) 6-oxidoreductase (hydroxylating); L-nicotine oxidase; nicotine dehydrogenase (incorrect) | |
| 1.5.99.5 | methylglutamate dehydrogenase | False | 0 | 27 | 0 | 10 | N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor | N-methyl-L-glutamate:acceptor oxidoreductase (demethylating) | None | N-methylglutamate dehydrogenase; N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating) | |
| 1.5.99.6 | spermidine dehydrogenase | False | 0 | 39 | 5 | 5 | spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor | spermidine:acceptor oxidoreductase | None | spermidine:(acceptor) oxidoreductase | |
| 1.5.99.12 | cytokinin dehydrogenase | False | 21 | 3315 | 30 | 34 | N6-prenyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced acceptor | N6-prenyladenine:acceptor oxidoreductase | None | N6-dimethylallyladenine:(acceptor) oxidoreductase; 6-N-dimethylallyladenine:acceptor oxidoreductase; OsCKX2; CKX; cytokinin oxidase/dehydrogenase; N6-dimethylallyladenine:acceptor oxidoreductase | |
| 1.6.1.1 | NAD(P)+ transhydrogenase (Si-specific) | False | 95 | 8421 | 7 | 11 | NADPH + NAD+ = NADP+ + NADH | NADPH:NAD+ oxidoreductase (Si-specific) | None | pyridine nucleotide transhydrogenase; transhydrogenase; NAD(P)+ transhydrogenase; nicotinamide adenine dinucleotide (phosphate) transhydrogenase; NAD+ transhydrogenase; NADH transhydrogenase; nicotinamide nucleotide transhydrogenase; NADPH-NAD+ transhydrogenase; pyridine nucleotide transferase; NADPH-NAD+ oxidoreductase; NADH-NADP+-transhydrogenase; NADPH:NAD+ transhydrogenase; H+-Thase; non-energy-linked transhydrogenase; NADPH:NAD+ oxidoreductase (B-specific); NAD(P)+ transhydrogenase (B-specific) | |
| 1.6.2.2 | cytochrome-b5 reductase | False | 89 | 12521 | 18 | 32 | NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 | NADH:ferricytochrome-b5 oxidoreductase | None | cytochrome b5 reductase; dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase; reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase; NADH-ferricytochrome b5 oxidoreductase; NADH-cytochrome b5 reductase; NADH 5alpha-reductase ; NADH-cytochrome-b5 reductase | |
| 1.6.2.4 | NADPH---hemoprotein reductase | False | 53 | 10073 | 41 | 117 | NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein | NADPH:hemoprotein oxidoreductase | None | CPR; FAD-cytochrome c reductase; NADP-cytochrome c reductase; NADP-cytochrome reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase; NADPH:ferrihemoprotein oxidoreductase; NADPH---cytochrome P-450 oxidoreductase; NADPH-cytochrome c oxidoreductase; NADPH-cytochrome c reductase; NADPH---cytochrome p-450 reductase; NADPH-ferricytochrome c oxidoreductase; NADPH-ferrihemoprotein reductase; TPNH2 cytochrome c reductase; TPNH-cytochrome c reductase; aldehyde reductase (NADPH-dependent); cytochrome P-450 reductase; cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent); dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase; ferrihemoprotein P-450 reductase; reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase; reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) | |
| 1.6.2.5 | NADPH---cytochrome-c2 reductase | True | 0 | 0 | 0 | 5 | NADPH + 2 ferricytochrome c2 = NADP+ + H+ + 2 ferrocytochrome c2 | NADPH:ferricytochrome-c2 oxidoreductase | None | cytochrome c2 reductase (reduced nicotinamide adenine dinucleotide phosphate); cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH) | |
| 1.6.2.6 | leghemoglobin reductase | False | 2 | 4 | 0 | 3 | NAD(P)H + H+ + 2 ferrileghemoglobin = NAD(P)+ + 2 ferroleghemoglobin | NAD(P)H:ferrileghemoglobin oxidoreductase | None | ferric leghemoglobin reductase | |
| 1.6.3.1 | NAD(P)H oxidase (H2O2-forming) | False | 23 | 4182 | 0 | 38 | NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 | NAD(P)H:oxygen oxidoreductase (H2O2-forming) | None | THOX2; ThOX; dual oxidase; p138tox; thyroid NADPH oxidase; thyroid oxidase; thyroid oxidase 2; NADPH oxidase; NAD(P)H:oxygen oxidoreductase; NAD(P)H oxidase | |
| 1.6.5.2 | NAD(P)H dehydrogenase (quinone) | False | 270 | 16108 | 29 | 40 | NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone | NAD(P)H:quinone oxidoreductase | None | menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD(P)H-quinone reductase; menadione oxidoreductase; NAD(P)H dehydrogenase; NAD(P)H menadione reductase; NAD(P)H-quinone dehydrogenase; NAD(P)H-quinone oxidoreductase; NAD(P)H: (quinone-acceptor)oxidoreductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; naphthoquinone reductase; p-benzoquinone reductase; reduced NAD(P)H dehydrogenase; viologen accepting pyridine nucleotide oxidoreductase; vitamin K reductase; diaphorase; reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase; vitamin-K reductase; NAD(P)H2 dehydrogenase (quinone); NQO1; QR1; NAD(P)H:(quinone-acceptor) oxidoreductase | |
| 1.6.5.4 | monodehydroascorbate reductase (NADH) | False | 18 | 1930 | 5 | 41 | NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate | NADH:monodehydroascorbate oxidoreductase | None | NADH:semidehydroascorbic acid oxidoreductase; MDHA; semidehydroascorbate reductase; AFR (ambiguous); AFR-reductase; ascorbic free radical reductase; ascorbate free radical reductase; SOR (ambiguous); MDAsA reductase (NADPH); SDA reductase; NADH:ascorbate radical oxidoreductase; NADH-semidehydroascorbate oxidoreductase; ascorbate free-radical reductase; NADH:AFR oxidoreductase; monodehydroascorbate reductase (NADH2) | |
| 1.6.5.5 | NADPH:quinone reductase | False | 15 | 6701 | 11 | 15 | NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone | NADPH:quinone oxidoreductase | None | NADPH2:quinone reductase | |
| 1.6.5.6 | p-benzoquinone reductase (NADPH) | False | 1 | 11 | 0 | 5 | NADPH + H+ + p-benzoquinone = NADP+ + hydroquinone | NADPH:p-benzoquinone oxidoreductase | None | None | |
| 1.6.5.7 | 2-hydroxy-1,4-benzoquinone reductase | False | 1 | 70 | 0 | 2 | 2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+ | NADH:2-hydroxy-1,4-benzoquinone oxidoreductase | None | hydroxybenzoquinone reductase; 1,2,4-trihydroxybenzene:NAD oxidoreductase | |
| 1.6.99.1 | NADPH dehydrogenase | False | 41 | 2845 | 64 | 18 | NADPH + H+ + acceptor = NADP+ + reduced acceptor | NADPH:acceptor oxidoreductase | None | NADPH2 diaphorase; NADPH diaphorase; OYE; diaphorase; dihydronicotinamide adenine dinucleotide phosphate dehydrogenase; NADPH-dehydrogenase; NADPH-diaphorase; NADPH2-dehydrogenase; old yellow enzyme; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase; TPNH dehydrogenase; TPNH-diaphorase; triphosphopyridine diaphorase; triphosphopyridine nucleotide diaphorase; NADPH2 dehydrogenase; NADPH:(acceptor) oxidoreductase | |
| 1.7.1.1 | nitrate reductase (NADH) | False | 25 | 476 | 0 | 65 | nitrite + NAD+ + H2O = nitrate + NADH + H+ | nitrite:NAD+ oxidoreductase | None | assimilatory nitrate reductase (ambiguous); NADH-nitrate reductase; NADH-dependent nitrate reductase; assimilatory NADH: nitrate reductase; nitrate reductase (NADH2); NADH2:nitrate oxidoreductase | |
| 1.7.1.2 | nitrate reductase [NAD(P)H] | False | 3 | 16 | 2 | 25 | nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+ | nitrite:NAD(P)+ oxidoreductase | None | assimilatory nitrate reductase ( ambiguous); assimilatory NAD(P)H-nitrate reductase; NAD(P)H bispecific nitrate reductase; nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)); nitrate reductase NAD(P)H; NAD(P)H-nitrate reductase; nitrate reductase [NAD(P)H2]; NAD(P)H2:nitrate oxidoreductase | |
| 1.7.1.3 | nitrate reductase (NADPH) | False | 9 | 1406 | 0 | 11 | nitrite + NADP+ + H2O = nitrate + NADPH + H+ | nitrite:NADP+ oxidoreductase | None | assimilatory nitrate reductase (ambiguous); assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase; NADPH-nitrate reductase; assimilatory NADPH-nitrate reductase; triphosphopyridine nucleotide-nitrate reductase; NADPH:nitrate reductase; nitrate reductase (NADPH2); NADPH2:nitrate oxidoreductase | |
| 1.7.1.4 | nitrite reductase [NAD(P)H] | False | 6 | 3445 | 2 | 18 | NH3 + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+ | ammonia:NAD(P)+ oxidoreductase | None | nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)); assimilatory nitrite reductase (ambiguous); nitrite reductase [NAD(P)H2]; NAD(P)H2:nitrite oxidoreductase; nit-6 (gene name) | |
| 1.7.1.5 | hyponitrite reductase | False | 0 | 2 | 0 | 1 | 2 hydroxylamine + 2 NAD+ = hyponitrous acid + 2 NADH + 2 H+ | hydroxylamine:NAD+ oxidoreductase | None | NADH2:hyponitrite oxidoreductase | |
| 1.7.1.6 | azobenzene reductase | False | 1 | 694 | 8 | 64 | N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ = 4-(dimethylamino)azobenzene + 2 NADPH + 2 H+ | N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase | None | new coccine (NC)-reductase; NC-reductase; azo-dye reductase; orange II azoreductase; NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase; orange I azoreductase; azo reductase; azoreductase; nicotinamide adenine dinucleotide (phosphate) azoreductase; NADPH2-dependent azoreductase; dimethylaminobenzene reductase; p-dimethylaminoazobenzene azoreductase; dibromopropylaminophenylazobenzoic azoreductase; N,N-dimethyl-4-phenylazoaniline azoreductase; p-aminoazobenzene reductase; methyl red azoreductase; NADPH2:4-(dimethylamino)azobenzene oxidoreductase | |
| 1.7.1.7 | GMP reductase | False | 198 | 13468 | 11 | 14 | IMP + NH3 + NADP+ = GMP + NADPH + H+ | inosine-5'-phosphate:NADP+ oxidoreductase (aminating) | None | guanosine 5'-monophosphate reductase; NADPH:GMP oxidoreductase (deaminating); guanosine monophosphate reductase; guanylate reductase; NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating); guanosine 5'-phosphate reductase | |
| 1.7.1.9 | nitroquinoline-N-oxide reductase | False | 1 | 0 | 0 | 7 | 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+ | 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase | None | 4-nitroquinoline 1-oxide reductase; 4NQO reductase; NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase | |
| 1.7.1.10 | hydroxylamine reductase (NADH) | True | 0 | 0 | 0 | 21 | NH3 + NAD+ + H2O = hydroxylamine + NADH + H+ | ammonium:NAD+ oxidoreductase | None | hydroxylamine reductase; ammonium dehydrogenase; NADH-hydroxylamine reductase; N-hydroxy amine reductase; hydroxylamine reductase (NADH2); NADH2:hydroxylamine oxidoreductase | |
| 1.7.1.11 | 4-(dimethylamino)phenylazoxybenzene reductase | True | 0 | 0 | 0 | 1 | 4-(dimethylamino)phenylazobenzene + NADP+ + H2O = 4-(dimethylamino)phenylazoxybenzene + NADPH + H+ | 4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase | None | N,N-dimethyl-p-aminoazobenzene oxide reductase; dimethylaminoazobenzene N-oxide reductase; NADPH-dependent DMAB N-oxide reductase; NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase | |
| 1.7.1.12 | N-hydroxy-2-acetamidofluorene reductase | True | 0 | 0 | 0 | 1 | 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+ | 2-acetamidofluorene:NAD(P)+ oxidoreductase | None | N-hydroxy-2-acetylaminofluorene reductase; NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase | |
| 1.7.2.1 | nitrite reductase (NO-forming) | False | 16 | 10997 | 171 | 46 | nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+ | nitric-oxide:ferricytochrome-c oxidoreductase | None | cd-cytochrome nitrite reductase; [nitrite reductase (cytochrome)] [misleading, see comments.]; cytochrome c-551:O2, NO2+ oxidoreductase; cytochrome cd; cytochrome cd1; hydroxylamine (acceptor) reductase; methyl viologen-nitrite reductase; nitrite reductase (cytochrome; NO-forming) | |
| 1.7.2.2 | nitrite reductase (cytochrome; ammonia-forming) | False | 79 | 8446 | 24 | 17 | NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+ | ammonia:ferricytochrome-c oxidoreductase | None | cytochrome c nitrite reductase; multiheme nitrite reductase | |
| 1.7.2.3 | trimethylamine-N-oxide reductase | False | 18 | 3594 | 6 | 13 | trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ | trimethylamine:cytochrome c oxidoreductase | None | TMAO reductase; TOR; torA (gene name); torZ (gene name); bisZ (gene name); trimethylamine-N-oxide reductase (cytochrome c) | |
| 1.7.3.1 | nitroalkane oxidase | False | 2 | 1 | 13 | 5 | a nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2 | nitroalkane:oxygen oxidoreductase | None | nitroethane oxidase; NAO; nitroethane:oxygen oxidoreductase | |
| 1.7.3.2 | acetylindoxyl oxidase | True | 0 | 0 | 0 | 1 | N-acetylindoxyl + O2 = N-acetylisatin + (?) | N-acetylindoxyl:oxygen oxidoreductase | None | None | |
| 1.7.3.3 | factor-independent urate hydroxylase | False | 32 | 7208 | 114 | 62 | urate + O2 + H2O = 5-hydroxyisourate + H2O2 | urate:oxygen oxidoreductase | None | uric acid oxidase; uricase; uricase II; urate oxidase | |
| 1.7.3.5 | 3-aci-nitropropanoate oxidase | True | 0 | 0 | 0 | 1 | 3-aci-nitropropanoate + O2 + H2O = 3-oxopropanoate + nitrite + H2O2 | 3-aci-nitropropanoate:oxygen oxidoreductase | None | propionate-3-nitronate oxidase | |
| 1.7.7.1 | ferredoxin---nitrite reductase | False | 9 | 1633 | 19 | 28 | NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+ | ammonia:ferredoxin oxidoreductase | None | None | |
| 1.7.7.2 | ferredoxin---nitrate reductase | False | 1 | 76 | 1 | 25 | nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin + 2 H+ | nitrite:ferredoxin oxidoreductase | None | assimilatory nitrate reductase (ambiguous); nitrate (ferredoxin) reductase; assimilatory ferredoxin-nitrate reductase | |
| 1.7.99.1 | hydroxylamine reductase | False | 158 | 9572 | 5 | 11 | NH3 + H2O + acceptor = hydroxylamine + reduced acceptor | ammonia:acceptor oxidoreductase | None | hydroxylamine (acceptor) reductase; ammonia:(acceptor) oxidoreductase | |
| 1.13.11.56 | 1,2-dihydroxynaphthalene dioxygenase | False | 5 | 15 | 0 | 4 | naphthalene-1,2-diol + O2 = 2-hydroxy-2H-chromene-2-carboxylate | naphthalene-1,2-diol:oxygen oxidoreductase | None | 1,2-DHN dioxygenase; DHNDO; 1,2-dihydroxynaphthalene oxygenase; 1,2-dihydroxynaphthalene:oxygen oxidoreductase | |
| 1.8.1.2 | assimilatory sulfite reductase (NADPH) | False | 239 | 10763 | 23 | 11 | hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+ | hydrogen-sulfide:NADP+ oxidoreductase | None | sulfite reductase (NADPH); sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADPH-sulfite reductase; NADPH-dependent sulfite reductase; H2S-NADP oxidoreductase; sulfite reductase (NADPH2); MET5 (gene name); MET10 (gene name); cysI (gene name); cysJ (gene name) | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | False | 78 | 66616 | 54 | 71 | protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+ | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | None | LDP-Glc; LDP-Val; dehydrolipoate dehydrogenase; diaphorase; dihydrolipoamide dehydrogenase; dihydrolipoamide:NAD+ oxidoreductase; dihydrolipoic dehydrogenase; dihydrothioctic dehydrogenase; lipoamide dehydrogenase (NADH); lipoamide oxidoreductase (NADH); lipoamide reductase; lipoamide reductase (NADH); lipoate dehydrogenase; lipoic acid dehydrogenase; lipoyl dehydrogenase; protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 1.8.1.5 | 2-oxopropyl-CoM reductase (carboxylating) | False | 1 | 4 | 7 | 2 | CoM + acetoacetate + NADP+ = 2-oxopropyl-CoM + CO2 + NADPH | 2-sulfanylethane-1-sulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating) | None | NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase; NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase; 2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating) | |
| 1.8.1.6 | cystine reductase | False | 0 | 2 | 0 | 8 | 2 L-cysteine + NAD+ = L-cystine + NADH + H+ | L-cysteine:NAD+ oxidoreductase | None | cystine reductase (NADH); NADH-dependent cystine reductase; cystine reductase (NADH2); NADH2:L-cystine oxidoreductase | |
| 1.8.1.7 | glutathione-disulfide reductase | False | 33 | 13672 | 16 | 84 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | glutathione:NADP+ oxidoreductase | None | glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase; NADPH-GSSG reductase; glutathione S-reductase; NADPH:oxidized-glutathione oxidoreductase | |
| 1.8.1.8 | protein-disulfide reductase | False | 64 | 14672 | 24 | 19 | protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+ | protein-dithiol:NAD(P)+ oxidoreductase | None | protein disulphide reductase; insulin-glutathione transhydrogenase; disulfide reductase; NAD(P)H2:protein-disulfide oxidoreductase | |
| 1.8.1.9 | thioredoxin-disulfide reductase | False | 96 | 48912 | 96 | 70 | thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | thioredoxin:NADP+ oxidoreductase | None | NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase | |
| 1.8.1.10 | CoA-glutathione reductase | False | 0 | 1 | 0 | 4 | CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+ | glutathione:NADP+ oxidoreductase (CoA-acylating) | None | coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH:CoA-glutathione oxidoreductase | |
| 1.8.1.11 | asparagusate reductase | True | 0 | 0 | 0 | 1 | 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD+ = asparagusate + NADH + H+ | 3-sulfanyl-2-(sulfanylmethyl)propanoate:NAD+ oxidoreductase | None | asparagusate dehydrogenase; asparagusic dehydrogenase; asparagusate reductase (NADH2); NADH2:asparagusate oxidoreductase; 3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase | |
| 1.8.1.12 | trypanothione-disulfide reductase | False | 5 | 72 | 45 | 17 | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | trypanothione:NADP+ oxidoreductase | None | trypanothione reductase; NADPH2:trypanothione oxidoreductase | |
| 1.8.1.13 | bis-gamma-glutamylcystine reductase | False | 0 | 7 | 0 | 1 | 2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+ | gamma-glutamylcysteine:NADP+ oxidoreductase | None | NADPH2:bis-gamma-glutamylcysteine oxidoreductase; GSR | |
| 1.8.1.14 | CoA-disulfide reductase | False | 20 | 1837 | 13 | 8 | 2 CoA + NADP+ = CoA-disulfide + NADPH + H+ | CoA:NADP+ oxidoreductase | None | CoA-disulfide reductase (NADH2); NADH2:CoA-disulfide oxidoreductase; CoA:NAD+ oxidoreductase (misleading); CoADR; coenzyme A disulfide reductase | |
| 1.8.1.15 | mycothione reductase | False | 2 | 912 | 1 | 3 | 2 mycothiol + NAD(P)+ = mycothione + NAD(P)H + H+ | mycothiol:NAD(P)+ oxidoreductase | None | mycothiol-disulfide reductase | |
| 1.8.2.1 | sulfite dehydrogenase (cytochrome) | False | 0 | 1454 | 1 | 18 | sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c + 2 H+ | sulfite:ferricytochrome-c oxidoreductase | None | sulfite cytochrome c reductase; sulfite-cytochrome c oxidoreductase; sulfite oxidase (ambiguous); sulfite dehydrogenase (ambiguous); sorAB (gene names) | |
| 1.8.2.2 | thiosulfate dehydrogenase | False | 4 | 145 | 9 | 18 | 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c | thiosulfate:ferricytochrome-c oxidoreductase | None | tsdA (gene name); tetrathionate synthase; thiosulfate oxidase; thiosulfate-oxidizing enzyme; thiosulfate-acceptor oxidoreductase | |
| 1.8.3.1 | sulfite oxidase | False | 7 | 1353 | 14 | 51 | sulfite + O2 + H2O = sulfate + H2O2 | sulfite:oxygen oxidoreductase | None | None | |
| 1.8.3.2 | thiol oxidase | False | 37 | 10865 | 34 | 34 | 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2 | thiol:oxygen oxidoreductase | None | sulfhydryl oxidase | |
| 1.8.3.3 | glutathione oxidase | True | 0 | 0 | 0 | 8 | 2 glutathione + O2 = glutathione disulfide + H2O2 | glutathione:oxygen oxidoreductase | None | None | |
| 1.8.3.4 | methanethiol oxidase | False | 11 | 3586 | 0 | 3 | methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2 | methanethiol:oxygen oxidoreductase | None | methylmercaptan oxidase; methyl mercaptan oxidase; (MM)-oxidase; MT-oxidase | |
| 1.8.3.5 | prenylcysteine oxidase | False | 6 | 828 | 0 | 4 | an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 | S-prenyl-L-cysteine:oxygen oxidoreductase | None | prenylcysteine lyase | |
| 1.8.4.1 | glutathione---homocystine transhydrogenase | False | 0 | 3 | 0 | 2 | 2 glutathione + homocystine = glutathione disulfide + 2 homocysteine | glutathione:homocystine oxidoreductase | None | None | |
| 1.8.4.2 | protein-disulfide reductase (glutathione) | False | 5 | 880 | 22 | 34 | 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol | glutathione:protein-disulfide oxidoreductase | None | glutathione-insulin transhydrogenase; insulin reductase; reductase, protein disulfide (glutathione); protein disulfide transhydrogenase; glutathione-protein disulfide oxidoreductase; protein disulfide reductase (glutathione); GSH-insulin transhydrogenase; protein-disulfide interchange enzyme; protein-disulfide isomerase/oxidoreductase; thiol:protein-disulfide oxidoreductase; thiol-protein disulphide oxidoreductase | |
| 1.8.4.3 | glutathione---CoA-glutathione transhydrogenase | True | 0 | 0 | 0 | 2 | CoA + glutathione disulfide = CoA-glutathione + glutathione | CoA:glutathione-disulfide oxidoreductase | None | glutathione-coenzyme A glutathione disulfide transhydrogenase; glutathione-coenzyme A glutathione disulfide transhydrogenase; glutathione coenzyme A-glutathione transhydrogenase; glutathione:coenzyme A-glutathione transhydrogenase; coenzyme A:oxidized-glutathione oxidoreductase; coenzyme A:glutathione-disulfide oxidoreductase | |
| 1.8.4.4 | glutathione---cystine transhydrogenase | True | 0 | 0 | 0 | 2 | 2 glutathione + cystine = glutathione disulfide + 2 cysteine | glutathione:cystine oxidoreductase | None | GSH-cystine transhydrogenase; NADPH-dependent GSH-cystine transhydrogenase | |
| 1.8.4.7 | enzyme-thiol transhydrogenase (glutathione-disulfide) | False | 0 | 1 | 1 | 3 | [xanthine dehydrogenase] + glutathione disulfide = [xanthine oxidase] + 2 glutathione | [xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase | None | [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase; enzyme-thiol transhydrogenase (oxidized-glutathione); glutathione-dependent thiol:disulfide oxidoreductase; thiol:disulphide oxidoreductase | |
| 1.8.4.8 | phosphoadenylyl-sulfate reductase (thioredoxin) | False | 99 | 4597 | 10 | 7 | adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin | adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming) | None | PAPS reductase, thioredoxin-dependent; PAPS reductase; thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase; 3'-phosphoadenylylsulfate reductase; thioredoxin:3'-phospho-adenylylsulfate reductase; phosphoadenosine-phosphosulfate reductase; adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming) | |
| 1.8.4.9 | adenylyl-sulfate reductase (glutathione) | False | 4 | 13 | 1 | 19 | AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione | AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) | None | 5'-adenylylsulfate reductase (also used for EC 1.8.99.2); AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming); plant-type 5'-adenylylsulfate reductase | |
| 1.8.4.10 | adenylyl-sulfate reductase (thioredoxin) | False | 59 | 17483 | 2 | 19 | AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin | AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) | None | thioredoxin-dependent 5'-adenylylsulfate reductase | |
| 1.8.5.1 | glutathione dehydrogenase (ascorbate) | False | 26 | 2939 | 6 | 40 | 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate | glutathione:dehydroascorbate oxidoreductase | None | dehydroascorbic reductase; dehydroascorbic acid reductase; glutathione dehydroascorbate reductase; DHA reductase ; dehydroascorbate reductase; GDOR; glutathione:dehydroascorbic acid oxidoreductase | |
| 1.8.5.2 | thiosulfate dehydrogenase (quinone) | False | 2 | 300 | 0 | 2 | 2 thiosulfate + 6-decylubiquinone = tetrathionate + 6-decylubiquinol | thiosulfate:6-decylubiquinone oxidoreductase | None | thiosulfate:quinone oxidoreductase; thiosulphate:quinone oxidoreductase; thiosulfate oxidoreductase, tetrathionate-forming; TQO | |
| 1.8.7.1 | assimilatory sulfite reductase (ferredoxin) | False | 12 | 10101 | 3 | 20 | hydrogen sulfide + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O = sulfite + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ | hydrogen-sulfide:ferredoxin oxidoreductase | None | ferredoxin-sulfite reductase; SIR (gene name); sulfite reductase (ferredoxin) | |
| 1.8.98.1 | dihydromethanophenazine:CoB-CoM heterodisulfide reductase | False | 8 | 2079 | 5 | 16 | CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine | CoB:CoM:methanophenazine oxidoreductase | None | hdrDE (gene names); CoB---CoM heterodisulfide reductase (ambiguous); heterodisulfide reductase (ambiguous); coenzyme B:coenzyme M:methanophenazine oxidoreductase | |
| 1.8.98.2 | sulfiredoxin | False | 6 | 1957 | 2 | 7 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming] | None | Srx1; sulphiredoxin; peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase | |
| 1.8.99.2 | adenylyl-sulfate reductase | False | 1 | 2718 | 6 | 85 | AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor | AMP,sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming) | None | adenosine phosphosulfate reductase; adenosine 5'-phosphosulfate reductase; APS-reductase; APS reductase; AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming) | |
| 1.9.6.1 | nitrate reductase (cytochrome) | False | 137 | 4155 | 0 | 30 | 2 ferrocytochrome + 2 H+ + nitrate = 2 ferricytochrome + nitrite | ferrocytochrome:nitrate oxidoreductase | None | respiratory nitrate reductase; benzyl viologen-nitrate reductase | |
| 1.10.1.1 | trans-acenaphthene-1,2-diol dehydrogenase | True | 0 | 0 | 0 | 7 | (+/-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthenequinone + 2 NADPH + 2 H+ | (+/-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase | None | trans-1,2-acenaphthenediol dehydrogenase | |
| 1.10.3.1 | catechol oxidase | False | 15 | 333 | 10 | 76 | 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O | 1,2-benzenediol:oxygen oxidoreductase | None | diphenol oxidase; o-diphenolase; polyphenol oxidase; pyrocatechol oxidase; dopa oxidase; catecholase; o-diphenol:oxygen oxidoreductase; o-diphenol oxidoreductase | |
| 1.10.3.2 | laccase | False | 94 | 11549 | 163 | 181 | 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O | benzenediol:oxygen oxidoreductase | None | urishiol oxidase; urushiol oxidase; p-diphenol oxidase | |
| 1.10.3.3 | L-ascorbate oxidase | False | 6 | 1337 | 4 | 36 | 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O | L-ascorbate:oxygen oxidoreductase | None | ascorbase; ascorbic acid oxidase; ascorbate oxidase; ascorbic oxidase; ascorbate dehydrogenase; L-ascorbic acid oxidase; AAO; L-ascorbate:O2 oxidoreductase; AA oxidase | |
| 1.10.3.4 | o-aminophenol oxidase | False | 2 | 8 | 0 | 5 | 4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O | 2-aminophenol:oxygen oxidoreductase | None | isophenoxazine synthase; o-aminophenol:O2 oxidoreductase; 2-aminophenol:O2 oxidoreductase | |
| 1.10.3.5 | 3-hydroxyanthranilate oxidase | True | 0 | 0 | 0 | 19 | 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 | 3-hydroxyanthranilate:oxygen oxidoreductase | None | 3-hydroxyanthranilic acid oxidase | |
| 1.10.3.6 | rifamycin-B oxidase | True | 0 | 0 | 0 | 4 | rifamycin B + O2 = rifamycin O + H2O2 | rifamycin-B:oxygen oxidoreductase | None | rifamycin B oxidase | |
| 1.11.1.1 | NADH peroxidase | False | 5 | 1292 | 8 | 28 | NADH + H+ + H2O2 = NAD+ + 2 H2O | NADH:hydrogen-peroxide oxidoreductase | None | DPNH peroxidase; NAD peroxidase; diphosphopyridine nucleotide peroxidase; NADH-peroxidase; nicotinamide adenine dinucleotide peroxidase; NADH2 peroxidase | |
| 1.11.1.2 | NADPH peroxidase | False | 6 | 1020 | 0 | 4 | NADPH + H+ + H2O2 = NADP+ + 2 H2O | NADPH:hydrogen-peroxide oxidoreductase | None | TPNH peroxidase; NADP peroxidase; nicotinamide adenine dinucleotide phosphate peroxidase; TPN peroxidase; triphosphopyridine nucleotide peroxidase; NADPH2 peroxidase | |
| 1.11.1.3 | fatty-acid peroxidase | True | 0 | 0 | 0 | 3 | palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O | hexadecanoate:hydrogen-peroxide oxidoreductase | None | long chain fatty acid peroxidase | |
| 1.11.1.5 | cytochrome-c peroxidase | False | 23 | 2906 | 222 | 26 | 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O | ferrocytochrome-c:hydrogen-peroxide oxidoreductase | None | cytochrome peroxidase; cytochrome c-551 peroxidase; apocytochrome c peroxidase; mesocytochrome c peroxidase azide; mesocytochrome c peroxidase cyanide; mesocytochrome c peroxidase cyanate; cytochrome c-H2O oxidoreductase; cytochrome c peroxidase | |
| 1.11.1.6 | catalase | False | 150 | 37235 | 166 | 138 | 2 H2O2 = O2 + 2 H2O | hydrogen-peroxide:hydrogen-peroxide oxidoreductase | None | equilase; caperase; optidase; catalase-peroxidase; CAT | |
| 1.11.1.7 | peroxidase | False | 192 | 31591 | 149 | 96 | 2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O | phenolic donor:hydrogen-peroxide oxidoreductase | None | lactoperoxidase; guaiacol peroxidase; plant peroxidase; Japanese radish peroxidase; horseradish peroxidase (HRP); soybean peroxidase (SBP); extensin peroxidase; heme peroxidase; oxyperoxidase; protoheme peroxidase; pyrocatechol peroxidase; scopoletin peroxidase; Coprinus cinereus peroxidase; Arthromyces ramosus peroxidase | |
| 1.11.1.8 | iodide peroxidase | False | 5 | 425 | 1 | 7 | (1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O;;(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;;(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;;(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O;;(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O | iodide:hydrogen-peroxide oxidoreductase | None | thyroid peroxidase; iodoperoxidase (heme type); iodide peroxidase-tyrosine iodinase; thyroperoxidase; tyrosine iodinase; TPO; iodinase | |
| 1.11.1.9 | glutathione peroxidase | False | 89 | 2042 | 16 | 50 | 2 glutathione + H2O2 = glutathione disulfide + 2 H2O | glutathione:hydrogen-peroxide oxidoreductase | None | GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase | |
| 1.11.1.10 | chloride peroxidase | False | 2 | 1945 | 34 | 5 | RH + chloride + H2O2 = RCl + 2 H2O | chloride:hydrogen-peroxide oxidoreductase | None | chloroperoxidase; CPO; vanadium haloperoxidase | |
| 1.11.1.11 | L-ascorbate peroxidase | False | 20 | 2908 | 45 | 59 | 2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O (overall reaction);;(1a) 2 L-ascorbate + H2O2 + 2 H+ = 2 monodehydroascorbate + 2 H2O;;(1b) 2 monodehydroascorbate = L-ascorbate + L-dehydroascorbate (spontaneous) | L-ascorbate:hydrogen-peroxide oxidoreductase | None | L-ascorbic acid peroxidase; L-ascorbic acid-specific peroxidase; ascorbate peroxidase; ascorbic acid peroxidase | |
| 1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase | False | 41 | 177 | 21 | 24 | 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O | glutathione:lipid-hydroperoxide oxidoreductase | None | peroxidation-inhibiting protein; PHGPX; peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing); phospholipid hydroperoxide glutathione peroxidase; hydroperoxide glutathione peroxidase | |
| 1.11.1.13 | manganese peroxidase | False | 7 | 3 | 20 | 94 | 2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O | Mn(II):hydrogen-peroxide oxidoreductase | None | peroxidase-M2; Mn-dependent (NADH-oxidizing) peroxidase | |
| 1.11.1.14 | lignin peroxidase | False | 12 | 1 | 6 | 38 | (1) 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H2O;;(2) 2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O | 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol:hydrogen-peroxide oxidoreductase | None | diarylpropane oxygenase; ligninase I; diarylpropane peroxidase; LiP; diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving); 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase (incorrect); (3,4-dimethoxyphenyl)methanol:hydrogen-peroxide oxidoreductase | |
| 1.11.1.24 | thioredoxin-dependent peroxiredoxin | False | 206 | 79389 | 12 | 63 | thioredoxin + ROOH = thioredoxin disulfide + H2O + ROH | thioredoxin:hydroperoxide oxidoreductase | None | thioredoxin peroxidase; bcp (gene name); tpx (gene name); PrxQ | |
| 1.12.1.2 | hydrogen dehydrogenase | False | 8 | 1032 | 0 | 20 | H2 + NAD+ = H+ + NADH | hydrogen:NAD+ oxidoreductase | None | H2:NAD+ oxidoreductase; NAD+-linked hydrogenase; bidirectional hydrogenase; hydrogenase | |
| 1.12.1.3 | hydrogen dehydrogenase (NADP+) | False | 6 | 2361 | 3 | 9 | H2 + NADP+ = H+ + NADPH | hydrogen:NADP+ oxidoreductase | None | NADP+-linked hydrogenase; NADP+-reducing hydrogenase; hydrogenase (ambiguous); hydrogenase I (ambiguous) | |
| 1.12.2.1 | cytochrome-c3 hydrogenase | False | 12 | 371 | 44 | 11 | H2 + 2 ferricytochrome c3 = 2 H+ + 2 ferrocytochrome c3 | hydrogen:ferricytochrome-c3 oxidoreductase | None | H2:ferricytochrome c3 oxidoreductase; cytochrome c3 reductase; cytochrome hydrogenase; hydrogenase [ambiguous] | |
| 1.12.5.1 | hydrogen:quinone oxidoreductase | False | 2 | 364 | 6 | 2 | H2 + menaquinone = menaquinol | hydrogen:quinone oxidoreductase | None | hydrogen-ubiquinone oxidoreductase; hydrogen:menaquinone oxidoreductase; membrane-bound hydrogenase; quinone-reactive Ni/Fe-hydrogenase | |
| 1.12.7.2 | ferredoxin hydrogenase | False | 8 | 1622 | 57 | 27 | H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ | hydrogen:ferredoxin oxidoreductase | None | H2 oxidizing hydrogenase; H2 producing hydrogenase [ambiguous]; bidirectional hydrogenase; hydrogen-lyase [ambiguous]; hydrogenase (ferredoxin); hydrogenase I; hydrogenase II; hydrogenlyase [ambiguous]; uptake hydrogenase [ambiguous] | |
| 1.12.98.1 | coenzyme F420 hydrogenase | False | 12 | 1373 | 6 | 10 | H2 + oxidized coenzyme F420 = reduced coenzyme F420 | hydrogen:coenzyme F420 oxidoreductase | None | 8-hydroxy-5-deazaflavin-reducing hydrogenase; F420-reducing hydrogenase; coenzyme F420-dependent hydrogenase | |
| 2.1.1.167 | 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase | False | 1 | 3 | 4 | 1 | S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA | S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O-)-methyltransferase | None | Spb1p (gene name); YCL054W (gene name) | |
| 1.12.98.2 | 5,10-methenyltetrahydromethanopterin hydrogenase | False | 13 | 133 | 18 | 6 | H2 + 5,10-methenyltetrahydromethanopterin = H+ + 5,10-methylenetetrahydromethanopterin | hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase | None | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase; nonmetal hydrogenase; N5,N10-methenyltetrahydromethanopterin hydrogenase; hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase | |
| 1.12.98.3 | Methanosarcina-phenazine hydrogenase | False | 6 | 866 | 0 | 4 | H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine | hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase | None | methanophenazine hydrogenase; methylviologen-reducing hydrogenase | |
| 1.12.99.6 | hydrogenase (acceptor) | False | 35 | 8613 | 54 | 84 | H2 + acceptor = reduced acceptor | hydrogen:acceptor oxidoreductase | None | H2 producing hydrogenase (ambiguous); hydrogen-lyase (ambiguous); hydrogenlyase (ambiguous); uptake hydrogenase (ambiguous); hydrogen:(acceptor) oxidoreductase | |
| 1.13.11.1 | catechol 1,2-dioxygenase | False | 10 | 3316 | 19 | 55 | catechol + O2 = cis,cis-muconate | catechol:oxygen 1,2-oxidoreductase | None | catechol-oxygen 1,2-oxidoreductase; 1,2-pyrocatechase; catechase; catechol 1,2-oxygenase; catechol dioxygenase; pyrocatechase; pyrocatechol 1,2-dioxygenase; CD I; CD II | |
| 1.13.11.2 | catechol 2,3-dioxygenase | False | 9 | 3374 | 9 | 39 | catechol + O2 = 2-hydroxymuconate-6-semialdehyde | catechol:oxygen 2,3-oxidoreductase (ring-opening) | None | 2,3-pyrocatechase; catechol 2,3-oxygenase; catechol oxygenase; metapyrocatechase; pyrocatechol 2,3-dioxygenase; xylE (gene name); catechol:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.75 | all-trans-8'-apo-beta-carotenal 15,15'-oxygenase | False | 1 | 92 | 10 | 3 | all-trans-8'-apo-beta-carotenal + O2 = all-trans-retinal + (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial | all-trans-8'-apo-beta-carotenal:oxygen 15,15'-oxidoreductase (bond-cleaving) | None | Diox1; ACO; 8'-apo-beta-carotenal 15,15'-oxygenase | |
| 1.13.11.3 | protocatechuate 3,4-dioxygenase | False | 8 | 6940 | 52 | 33 | 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate | protocatechuate:oxygen 3,4-oxidoreductase (ring-opening) | None | protocatechuate oxygenase; protocatechuic acid oxidase; protocatechuic 3,4-dioxygenase; protocatechuic 3,4-oxygenase; protocatechuate:oxygen 3,4-oxidoreductase (decyclizing) | |
| 1.13.11.4 | gentisate 1,2-dioxygenase | False | 5 | 1453 | 12 | 25 | 2,5-dihydroxybenzoate + O2 = maleylpyruvate | gentisate:oxygen 1,2-oxidoreductase (ring-opening) | None | gentisate oxygenase; 2,5-dihydroxybenzoate dioxygenase; gentisate dioxygenase; gentisic acid oxidase; gentisate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.5 | homogentisate 1,2-dioxygenase | False | 85 | 12962 | 5 | 33 | homogentisate + O2 = 4-maleylacetoacetate | homogentisate:oxygen 1,2-oxidoreductase (ring-opening) | None | homogentisicase; homogentisate oxygenase; homogentisate dioxygenase; homogentisate oxidase; homogentisic acid oxidase; homogentisic acid oxygenase; homogentisic oxygenase; homogentisate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase | False | 57 | 6410 | 37 | 12 | 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde | 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (ring-opening) | None | 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid oxygenase; 3-hydroxyanthranilic oxygenase; 3-hydroxyanthranilic acid oxidase; 3HAO; 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) | |
| 1.13.11.8 | protocatechuate 4,5-dioxygenase | False | 2 | 1415 | 6 | 7 | 3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde | 3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening) | None | protocatechuate 4,5-oxygenase; protocatechuic 4,5-dioxygenase; protocatechuic 4,5-oxygenase; protocatechuate:oxygen 4,5-oxidoreductase (decyclizing); protocatechuate:oxygen 4,5-oxidoreductase (ring-opening) | |
| 1.13.11.9 | 2,5-dihydroxypyridine 5,6-dioxygenase | False | 1 | 280 | 3 | 4 | 2,5-dihydroxypyridine + O2 = N-formylmaleamic acid | 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase | None | 2,5-dihydroxypyridine oxygenase; pyridine-2,5-diol dioxygenase; NicX | |
| 1.13.11.10 | 7,8-dihydroxykynurenate 8,8a-dioxygenase | True | 0 | 0 | 0 | 1 | 7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate | 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (ring-opening) | None | 7,8-dihydroxykynurenate oxygenase; 7,8-dihydroxykynurenate 8,8alpha-dioxygenase; 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing) | |
| 1.13.11.11 | tryptophan 2,3-dioxygenase | False | 96 | 10105 | 25 | 10 | L-tryptophan + O2 = N-formyl-L-kynurenine | L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) | None | tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.12 | linoleate 13S-lipoxygenase | False | 25 | 261 | 35 | 25 | (1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;;(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate | linoleate:oxygen 13-oxidoreductase | None | 13-lipoxidase; carotene oxidase; 13-lipoperoxidase; fat oxidase; 13-lipoxydase; lionoleate:O2 13-oxidoreductase | |
| 1.13.11.14 | 2,3-dihydroxybenzoate 3,4-dioxygenase | False | 0 | 36 | 0 | 3 | 2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde | 2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (ring-opening) | None | o-pyrocatechuate oxygenase; 2,3-dihydroxybenzoate 1,2-dioxygenase; 2,3-dihydroxybenzoic oxygenase; 2,3-dihydroxybenzoate oxygenase; 2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing) | |
| 1.13.11.15 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | False | 1 | 2292 | 20 | 20 | 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde | 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (ring-opening) | None | 3,4-dihydroxyphenylacetic acid 2,3-dioxygenase; HPC dioxygenase; homoprotocatechuate 2,3-dioxygenase; 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.16 | 3-carboxyethylcatechol 2,3-dioxygenase | False | 42 | 1566 | 1 | 4 | (1) 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate;;(2) (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate | 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (ring-opening) | None | 2,3-dihydroxy-beta-phenylpropionic dioxygenase; 2,3-dihydroxy-beta-phenylpropionate oxygenase; 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase; 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.17 | indole 2,3-dioxygenase | False | 0 | 1 | 0 | 5 | indole + O2 = 2-formylaminobenzaldehyde | indole:oxygen 2,3-oxidoreductase (ring-opening) | None | indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.18 | persulfide dioxygenase | False | 4 | 31 | 4 | 16 | S-sulfanylglutathione + O2 + H2O = glutathione + sulfite + 2 H+ (overall reaction);;(1a) S-sulfanylglutathione + O2 = S-sulfinatoglutathione + H+;;(1b) S-sulfinatoglutathione + H2O = glutathione + sulfite + H+ (spontaneous) | S-sulfanylglutathione:oxygen oxidoreductase | None | sulfur oxygenase (incorrect); sulfur:oxygen oxidoreductase (incorrect); sulfur dioxygenase (incorrect) | |
| 1.13.11.19 | cysteamine dioxygenase | False | 3 | 19 | 2 | 13 | cysteamine + O2 = hypotaurine | 2-aminoethanethiol:oxygen oxidoreductase | None | ADO (gene name); persulfurase; cysteamine oxygenase; cysteamine:oxygen oxidoreductase | |
| 1.13.11.20 | cysteine dioxygenase | False | 19 | 6965 | 83 | 18 | L-cysteine + O2 = 3-sulfinoalanine | L-cysteine:oxygen oxidoreductase | None | cysteine oxidase | |
| 1.13.11.22 | caffeate 3,4-dioxygenase | True | 0 | 0 | 0 | 1 | 3,4-dihydroxy-trans-cinnamate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate | 3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (ring-opening) | None | 3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing) | |
| 1.13.11.23 | 2,3-dihydroxyindole 2,3-dioxygenase | True | 0 | 0 | 0 | 1 | 2,3-dihydroxyindole + O2 = anthranilate + CO2 | 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (ring-opening) | None | 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.24 | quercetin 2,3-dioxygenase | False | 19 | 2359 | 21 | 8 | quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+ | quercetin:oxygen 2,3-oxidoreductase (ring-opening) | None | quercetinase; flavonol 2,4-oxygenase; quercetin:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.25 | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase | False | 3 | 153 | 0 | 2 | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening) | None | steroid 4,5-dioxygenase; 3-alkylcatechol 2,3-dioxygenase; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing) | |
| 1.13.11.26 | peptide-tryptophan 2,3-dioxygenase | True | 0 | 0 | 0 | 4 | [protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine | [protein]-L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) | None | pyrrolooxygenase; peptidyltryptophan 2,3-dioxygenase; tryptophan pyrrolooxygenase; [protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase | False | 30 | 9300 | 83 | 34 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 | 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) | None | p-hydroxyphenylpyruvic hydroxylase; p-hydroxyphenylpyruvate hydroxylase; p-hydroxyphenylpyruvate oxidase; p-hydroxyphenylpyruvic oxidase; p-hydroxyphenylpyruvate dioxygenase; p-hydroxyphenylpyruvic acid hydroxylase; 4-hydroxyphenylpyruvic acid dioxygenase | |
| 1.13.11.28 | 2,3-dihydroxybenzoate 2,3-dioxygenase | False | 0 | 1 | 0 | 1 | 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate | 2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (ring-opening) | None | 2,3-dihydroxybenzoate 2,3-oxygenase; 2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.29 | stizolobate synthase | False | 6 | 2556 | 1 | 1 | L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde | 3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing) | None | None | |
| 1.13.11.30 | stizolobinate synthase | True | 0 | 0 | 0 | 1 | L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde | 3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing) | None | None | |
| 1.13.11.31 | arachidonate 12-lipoxygenase | False | 12 | 189 | 2 | 21 | arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | arachidonate:oxygen 12-oxidoreductase | None | Delta12-lipoxygenase; 12-lipoxygenase; 12Delta-lipoxygenase; C-12 lipoxygenase; 12S-lipoxygenase; leukotriene A4 synthase; LTA4 synthase | |
| 1.13.11.33 | arachidonate 15-lipoxygenase | False | 13 | 229 | 8 | 24 | arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | arachidonate:oxygen 15-oxidoreductase | None | 15-lipoxygenase; linoleic acid omega6-lipoxygenase; omega6 lipoxygenase | |
| 1.13.11.34 | arachidonate 5-lipoxygenase | False | 4 | 79 | 9 | 14 | arachidonate + O2 = leukotriene A4 + H2O (overall reaction);;(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate;;(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O | arachidonate:oxygen 5-oxidoreductase | None | leukotriene-A4 synthase; Delta5-lipoxygenase; 5Delta-lipoxygenase; arachidonic 5-lipoxygenase; arachidonic acid 5-lipoxygenase; C-5-lipoxygenase; LTA synthase; leukotriene A4 synthase | |
| 1.13.11.35 | pyrogallol 1,2-oxygenase | True | 0 | 0 | 0 | 1 | 1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate | 1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (ring-opening) | None | pyrogallol 1,2-dioxygenase; 1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.36 | chloridazon-catechol dioxygenase | True | 0 | 0 | 0 | 2 | 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone | 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (ring-opening) | None | 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.37 | hydroxyquinol 1,2-dioxygenase | False | 6 | 383 | 2 | 19 | hydroxyquinol + O2 = maleylacetate | hydroxyquinol:oxygen 1,2-oxidoreductase (ring-opening) | None | hydroxyquinol dioxygenase; benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing); benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (ring-opening) | |
| 1.13.11.38 | 1-hydroxy-2-naphthoate 1,2-dioxygenase | False | 1 | 14 | 0 | 4 | 1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate | 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (ring-opening) | None | 1-hydroxy-2-naphthoate dioxygenase; 1-hydroxy-2-naphthoate-degrading enzyme; 1-hydroxy-2-naphthoic acid dioxygenase; 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.39 | biphenyl-2,3-diol 1,2-dioxygenase | False | 8 | 687 | 18 | 28 | biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate | biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (ring-opening) | None | 2,3-dihydroxybiphenyl dioxygenase; biphenyl-2,3-diol dioxygenase; bphC (gene name); biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.40 | arachidonate 8-lipoxygenase | False | 1 | 4 | 5 | 7 | arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate | arachidonate:oxygen 8-oxidoreductase | None | 8-lipoxygenase; 8(R)-lipoxygenase | |
| 1.13.11.41 | 2,4'-dihydroxyacetophenone dioxygenase | False | 0 | 29 | 2 | 2 | 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate | 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving) | None | (4-hydroxybenzoyl)methanol oxygenase | |
| 1.13.11.43 | lignostilbene alphabeta-dioxygenase | False | 2 | 29 | 3 | 1 | 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin | 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving) | None | None | |
| 1.13.11.45 | linoleate 11-lipoxygenase | False | 6 | 451 | 1 | 7 | linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate | linoleate:oxygen 11S-oxidoreductase | None | linoleate dioxygenase; manganese lipoxygenase | |
| 1.13.11.46 | 4-hydroxymandelate synthase | False | 1 | 50 | 2 | 2 | 4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 | (S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) | None | 4-hydroxyphenylpyruvate dioxygenase II | |
| 1.13.11.47 | 3-hydroxy-4-oxoquinoline 2,4-dioxygenase | False | 1 | 5 | 1 | 3 | 3-hydroxy-1H-quinolin-4-one + O2 = N-formylanthranilate + CO | 3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming) | None | (1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase; 3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase; 3-hydroxy-4(1H)-one, 2,4-dioxygenase; quinoline-3,4-diol 2,4-dioxygenase | |
| 1.13.11.48 | 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase | False | 1 | 16 | 11 | 3 | 3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO | 3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming) | None | (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase | |
| 1.13.11.49 | chlorite O2-lyase | False | 2 | 95 | 15 | 17 | chloride + O2 = chlorite | chloride:oxygen oxidoreductase | None | None | |
| 1.13.11.50 | acetylacetone-cleaving enzyme | False | 1 | 13 | 1 | 1 | pentane-2,4-dione + O2 = acetate + 2-oxopropanal | acetylacetone:oxygen oxidoreductase | None | Dke1; acetylacetone dioxygenase; diketone cleaving dioxygenase; diketone cleaving enzyme | |
| 1.13.11.51 | 9-cis-epoxycarotenoid dioxygenase | False | 15 | 995 | 1 | 41 | (1) a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal;;(2) 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al;;(3) 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al | 9-cis-epoxycarotenoid 11,12-dioxygenase | None | nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14 | |
| 1.13.12.1 | arginine 2-monooxygenase | False | 0 | 1 | 0 | 8 | L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O | L-arginine:oxygen 2-oxidoreductase (decarboxylating) | None | arginine monooxygenase; arginine decarboxylase (incorrect); arginine oxygenase (decarboxylating); arginine decarboxy-oxidase | |
| 1.13.12.2 | lysine 2-monooxygenase | False | 0 | 22 | 0 | 3 | L-lysine + O2 = 5-aminopentanamide + CO2 + H2O | L-lysine:oxygen 2-oxidoreductase (decarboxylating) | None | lysine oxygenase; lysine monooxygenase; L-lysine-2-monooxygenase | |
| 1.13.12.3 | tryptophan 2-monooxygenase | False | 7 | 6495 | 1 | 5 | L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O | L-tryptophan:oxygen 2-oxidoreductase (decarboxylating) | None | tms1 (gene name); iaaM (gene name) | |
| 1.13.12.4 | lactate 2-monooxygenase | False | 1 | 329 | 7 | 2 | (S)-lactate + O2 = acetate + CO2 + H2O | (S)-lactate:oxygen 2-oxidoreductase (decarboxylating) | None | lactate oxidative decarboxylase; lactate oxidase; lactic oxygenase; lactate oxygenase; lactic oxidase; L-lactate monooxygenase; lactate monooxygenase; L-lactate-2-monooxygenase | |
| 1.13.12.5 | Renilla-type luciferase | False | 1 | 13 | 13 | 10 | coelenterazine h + O2 = excited coelenteramide h monoanion + CO2 (over-all reaction);;(1a) coelenterazine h + O2 = coelenterazine h dioxetanone;;(1b) coelenterazine h dioxetanone = excited coelenteramide h monoanion + CO2 | coelenterazine h:oxygen 2-oxidoreductase (decarboxylating) | None | Renilla-luciferin 2-monooxygenase; luciferase (Renilla luciferin); Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating) | |
| 1.13.12.6 | Cypridina-luciferin 2-monooxygenase | False | 1 | 3 | 0 | 5 | Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + hnu | Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating) | None | Cypridina-type luciferase; luciferase (Cypridina luciferin); Cypridina luciferase | |
| 1.13.12.7 | firefly luciferase | False | 5 | 2240 | 25 | 23 | D-firefly luciferin + O2 + ATP = firefly oxyluciferin + CO2 + AMP + diphosphate + hnu | D-firefly luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing) | None | Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing) | |
| 1.13.12.8 | Watasenia-luciferin 2-monooxygenase | True | 0 | 0 | 0 | 4 | Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + hnu | Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating) | None | Watasenia-type luciferase | |
| 1.13.12.9 | phenylalanine 2-monooxygenase | False | 1 | 9 | 6 | 1 | L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O | L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating) | None | L-phenylalanine oxidase (deaminating and decarboxylating); phenylalanine (deaminating, decarboxylating)oxidase | |
| 1.13.12.13 | Oplophorus-luciferin 2-monooxygenase | False | 1 | 0 | 19 | 2 | Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu | Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) | None | Oplophorus luciferase | |
| 1.13.99.1 | inositol oxygenase | False | 13 | 4699 | 3 | 11 | myo-inositol + O2 = D-glucuronate + H2O | myo-inositol:oxygen oxidoreductase | None | meso-inositol oxygenase; myo-inositol oxygenase; MOO | |
| 1.13.99.3 | tryptophan 2'-dioxygenase | True | 0 | 0 | 0 | 3 | L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3 | L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving) | None | indole-3-alkane alpha-hydroxylase; tryptophan side-chain alpha,beta-oxidase; tryptophan side chain oxidase II; tryptophan side-chain oxidase; TSO; indolyl-3-alkan alpha-hydroxylase; tryptophan side chain oxidase type I; TSO I ; TSO II; tryptophan side chain oxidase | |
| 1.14.11.1 | gamma-butyrobetaine dioxygenase | False | 7 | 1147 | 12 | 7 | 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | alpha-butyrobetaine hydroxylase; gamma-butyrobetaine hydroxylase; butyrobetaine hydroxylase | |
| 1.14.11.2 | procollagen-proline 4-dioxygenase | False | 29 | 8000 | 15 | 34 | procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) | None | P4HA (gene name); P4HB (gene name); protocollagen hydroxylase; proline hydroxylase; proline,2-oxoglutarate 4-dioxygenase; collagen proline hydroxylase; hydroxylase, collagen proline; peptidyl proline hydroxylase; proline protocollagen hydroxylase; proline, 2-oxoglutarate dioxygenase; prolyl hydroxylase; prolylprotocollagen dioxygenase; prolylprotocollagen hydroxylase; protocollagen proline 4-hydroxylase; protocollagen proline dioxygenase; protocollagen proline hydroxylase; protocollagen prolyl hydroxylase; prolyl 4-hydroxylase; prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating; procollagen-proline 4-dioxygenase (ambiguous) | |
| 1.14.11.3 | pyrimidine-deoxynucleoside 2'-dioxygenase | True | 0 | 0 | 0 | 6 | 2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2 | 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating) | None | deoxyuridine 2'-dioxygenase; deoxyuridine 2'-hydroxylase; pyrimidine deoxyribonucleoside 2'-hydroxylase; thymidine 2'-dioxygenase; thymidine 2'-hydroxylase; thymidine 2-oxoglutarate dioxygenase; thymidine dioxygenase | |
| 1.14.11.4 | procollagen-lysine 5-dioxygenase | False | 16 | 3261 | 16 | 11 | [procollagen]-L-lysine + 2-oxoglutarate + O2 = [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | [procollagen]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) | None | lysine hydroxylase; lysine,2-oxoglutarate 5-dioxygenase; protocollagen lysine dioxygenase; collagen lysine hydroxylase; lysine-2-oxoglutarate dioxygenase; lysyl hydroxylase; lysylprotocollagen dioxygenase; protocollagen lysyl hydroxylase; peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase; peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase; protocollagen lysine hydroxylase; procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating); L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) | |
| 1.14.11.6 | thymine dioxygenase | False | 15 | 96 | 2 | 5 | thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2 | thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating) | None | thymine 7-hydroxylase; 5-hydroxy-methyluracil dioxygenase; 5-hydroxymethyluracil oxygenase | |
| 1.14.11.7 | procollagen-proline 3-dioxygenase | False | 10 | 3128 | 0 | 5 | [procollagen]-L-proline + 2-oxoglutarate + O2 = [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 | [procollagen]-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | proline,2-oxoglutarate 3-dioxygenase; prolyl 3-hydroxylase; protocollagen proline 3-hydroxylase; prolyl-4-hydroxyprolyl-glycyl-peptide,2-oxoglutarate:oxygen oxidoreductase, 3-hydroxylating | |
| 1.14.11.8 | trimethyllysine dioxygenase | False | 7 | 2510 | 0 | 6 | N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 | N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | trimethyllysine alpha-ketoglutarate dioxygenase; TML-alpha-ketoglutarate dioxygenase; TML hydroxylase; 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | |
| 1.14.11.9 | flavanone 3-dioxygenase | False | 22 | 510 | 0 | 53 | a (2S)-flavan-4-one + 2-oxoglutarate + O2 = a (2R,3R)-dihydroflavonol + succinate + CO2 | (2S)-flavan-4-one,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | naringenin 3-hydroxylase; flavanone 3-hydroxylase; flavanone 3beta-hydroxylase; flavanone synthase I; (2S)-flavanone 3-hydroxylase; naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating); F3H; flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | |
| 1.14.11.10 | pyrimidine-deoxynucleoside 1'-dioxygenase | True | 0 | 0 | 0 | 1 | 2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + 2-deoxyribonolactone + succinate + CO2 | 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating) | None | deoxyuridine-uridine 1'-dioxygenase | |
| 1.14.11.11 | hyoscyamine (6S)-dioxygenase | False | 1 | 27 | 10 | 14 | L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2 | L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating] | None | hyoscyamine 6beta-hydroxylase; hyoscyamine 6beta-dioxygenase; hyoscyamine 6-hydroxylase | |
| 1.14.11.12 | gibberellin-44 dioxygenase | False | 0 | 53 | 0 | 2 | gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2 | (gibberellin-44),2-oxoglutarate:oxygen oxidoreductase | None | oxygenase, gibberellin A44 oxidase; (gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase | |
| 1.14.11.13 | gibberellin 2beta-dioxygenase | False | 15 | 108 | 1 | 18 | gibberellin 1 + 2-oxoglutarate + O2 = 2beta-hydroxygibberellin 1 + succinate + CO2 | (gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating) | None | gibberellin 2beta-hydroxylase | |
| 1.14.11.15 | gibberellin 3beta-dioxygenase | False | 10 | 119 | 1 | 26 | gibberellin 20 + 2-oxoglutarate + O2 = gibberellin 1 + succinate + CO2 | (gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) | None | gibberellin 3beta-hydroxylase; (gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating) | |
| 1.14.11.16 | peptide-aspartate beta-dioxygenase | False | 3 | 200 | 47 | 4 | peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 | peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | aspartate beta-hydroxylase; aspartylpeptide beta-dioxygenase | |
| 1.14.11.17 | taurine dioxygenase | False | 2 | 2664 | 11 | 4 | taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2 | taurine, 2-oxoglutarate:oxygen oxidoreductase (sulfite-forming) | None | 2-aminoethanesulfonate dioxygenase; alpha-ketoglutarate-dependent taurine dioxygenase | |
| 1.14.11.18 | phytanoyl-CoA dioxygenase | False | 9 | 2080 | 1 | 5 | phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2 | phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) | None | phytanoyl-CoA hydroxylase | |
| 1.14.11.20 | deacetoxyvindoline 4-hydroxylase | False | 1 | 194 | 0 | 1 | deacetoxyvindoline + 2-oxoglutarate + O2 = deacetylvindoline + succinate + CO2 | deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating) | None | desacetoxyvindoline 4-hydroxylase; desacetyoxyvindoline-17-hydroxylase; D17H; desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating) | |
| 1.14.11.21 | clavaminate synthase | False | 2 | 34 | 3 | 2 | (1) deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2;;(2) proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O;;(3) dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O | deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | clavaminate synthase 2; clavaminic acid synthase | |
| 1.14.11.24 | 2'-deoxymugineic-acid 2'-dioxygenase | False | 1 | 3 | 0 | 1 | 2'-deoxymugineic acid + 2-oxoglutarate + O2 = mugineic acid + succinate + CO2 | 2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) | None | IDS3 | |
| 1.14.11.25 | mugineic-acid 3-dioxygenase | False | 1 | 3 | 0 | 1 | (1) mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2;;(2) 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2 | mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | IDS2 | |
| 1.14.11.26 | deacetoxycephalosporin-C hydroxylase | False | 3 | 19 | 0 | 4 | deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2 | deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | deacetylcephalosporin C synthase; 3'-methylcephem hydroxylase; DACS; DAOC hydroxylase; deacetoxycephalosporin C hydroxylase | |
| 1.14.12.1 | anthranilate 1,2-dioxygenase (deaminating, decarboxylating) | False | 4 | 1080 | 0 | 10 | anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3 | anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating) | None | anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase | |
| 1.14.12.3 | benzene 1,2-dioxygenase | False | 6 | 141 | 0 | 3 | benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+ | benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | benzene hydroxylase; benzene dioxygenase | |
| 1.14.12.7 | phthalate 4,5-dioxygenase | False | 2 | 382 | 1 | 4 | phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ | phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating) | None | PDO ; phthalate dioxygenase | |
| 1.14.12.8 | 4-sulfobenzoate 3,4-dioxygenase | True | 0 | 0 | 0 | 1 | 4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + sulfite + NAD+ | 4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming) | None | 4-sulfobenzoate dioxygenase; 4-sulfobenzoate 3,4-dioxygenase system | |
| 1.14.12.9 | 4-chlorophenylacetate 3,4-dioxygenase | True | 0 | 0 | 0 | 1 | 4-chlorophenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+ | 4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating) | None | None | |
| 1.14.12.10 | benzoate 1,2-dioxygenase | False | 2 | 1620 | 1 | 8 | benzoate + NADH + H+ + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ | benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | benzoate hydroxylase; benzoate hydroxylase; benzoic hydroxylase; benzoate dioxygenase; benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating) [incorrect] | |
| 1.14.12.11 | toluene dioxygenase | False | 4 | 8 | 2 | 4 | toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+ | toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | toluene 2,3-dioxygenase | |
| 1.14.12.12 | naphthalene 1,2-dioxygenase | False | 5 | 132 | 29 | 10 | naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ | naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | naphthalene dioxygenase; naphthalene oxygenase; NDO | |
| 1.14.12.13 | 2-halobenzoate 1,2-dioxygenase | False | 2 | 572 | 0 | 6 | a 2-halobenzoate + NADH + H+ + O2 = catechol + a halide anion + NAD+ + CO2 | 2-halobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dehalogenating, decarboxylating) | None | 2-chlorobenzoate 1,2-dioxygenase | |
| 1.14.12.14 | 2-aminobenzenesulfonate 2,3-dioxygenase | False | 2 | 36 | 0 | 1 | 2-aminobenzenesulfonate + NADH + H+ + O2 = 2,3-dihydroxybenzenesulfonate + NH3 + NAD+ | 2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming) | None | 2-aminosulfobenzene 2,3-dioxygenase | |
| 1.14.12.15 | terephthalate 1,2-dioxygenase | False | 6 | 100 | 3 | 4 | terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ | benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | benzene-1,4-dicarboxylate 1,2-dioxygenase; 1,4-dicarboxybenzoate 1,2-dioxygenase | |
| 1.14.12.16 | 2-hydroxyquinoline 5,6-dioxygenase | True | 0 | 0 | 0 | 1 | quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+ | quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating) | None | 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase; quinolin-2-ol 5,6-dioxygenase; quinolin-2(1H)-one 5,6-dioxygenase | |
| 1.14.12.17 | nitric oxide dioxygenase | False | 47 | 14991 | 5 | 19 | 2 nitric oxide + 2 O2 + NAD(P)H = 2 nitrate + NAD(P)+ + H+ | nitric oxide,NAD(P)H:oxygen oxidoreductase | None | None | |
| 1.14.12.18 | biphenyl 2,3-dioxygenase | False | 9 | 369 | 13 | 28 | biphenyl + NADH + H+ + O2 = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ | biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating) | None | biphenyl dioxygenase | |
| 1.14.12.19 | 3-phenylpropanoate dioxygenase | False | 27 | 1729 | 1 | 2 | (1) 3-phenylpropanoate + NADH + H+ + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+;;(2) (2E)-3-phenylprop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD+ | 3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) | None | HcaA1A2CD; Hca dioxygenase; 3-phenylpropionate dioxygenase | |
| 1.14.13.1 | salicylate 1-monooxygenase | False | 2 | 1298 | 10 | 20 | salicylate + NADH + 2 H+ + O2 = catechol + NAD+ + H2O + CO2 | salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | None | salicylate hydroxylase; salicylate 1-hydroxylase; salicylate monooxygenase; salicylate hydroxylase (decarboxylating) | |
| 1.14.13.2 | 4-hydroxybenzoate 3-monooxygenase | False | 3 | 5167 | 34 | 25 | 4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O | 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating) | None | p-hydroxybenzoate hydrolyase; p-hydroxybenzoate hydroxylase; 4-hydroxybenzoate 3-hydroxylase; 4-hydroxybenzoate monooxygenase; 4-hydroxybenzoic hydroxylase; p-hydroxybenzoate-3-hydroxylase; p-hydroxybenzoic acid hydrolase; p-hydroxybenzoic acid hydroxylase; p-hydroxybenzoic hydroxylase | |
| 1.14.13.4 | melilotate 3-monooxygenase | True | 0 | 0 | 0 | 2 | 3-(2-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O | 3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating) | None | 2-hydroxyphenylpropionate hydroxylase; melilotate hydroxylase; 2-hydroxyphenylpropionic hydroxylase; melilotic hydroxylase | |
| 1.14.13.5 | imidazoleacetate 4-monooxygenase | True | 0 | 0 | 0 | 1 | 4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O | 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating) | None | imidazoleacetic hydroxylase; imidazoleacetate hydroxylase; imidazoleacetic monooxygenase | |
| 1.14.13.6 | orcinol 2-monooxygenase | True | 0 | 0 | 0 | 3 | orcinol + NADH + H+ + O2 = 2,3,5-trihydroxytoluene + NAD+ + H2O | orcinol,NADH:oxygen oxidoreductase (2-hydroxylating) | None | orcinol hydroxylase | |
| 1.14.13.7 | phenol 2-monooxygenase (NADPH) | False | 4 | 1155 | 3 | 25 | phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O | phenol,NADPH:oxygen oxidoreductase (2-hydroxylating) | None | phenol hydroxylase; phenol o-hydroxylase | |
| 1.14.13.8 | flavin-containing monooxygenase | False | 27 | 1336 | 16 | 29 | N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O | N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming) | None | dimethylaniline oxidase; dimethylaniline N-oxidase; FAD-containing monooxygenase; N,N-dimethylaniline monooxygenase; DMA oxidase; flavin mixed function oxidase; Ziegler's enzyme; mixed-function amine oxidase; FMO; FMO-I; FMO-II; FMO1; FMO2; FMO3; FMO4; FMO5; flavin monooxygenase; methylphenyltetrahydropyridine N-monooxygenase; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase; dimethylaniline monooxygenase (N-oxide-forming) | |
| 1.14.13.9 | kynurenine 3-monooxygenase | False | 55 | 5171 | 31 | 20 | L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O | L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) | None | kynurenine 3-hydroxylase; kynurenine hydroxylase; L-kynurenine-3-hydroxylase | |
| 1.14.13.10 | 2,6-dihydroxypyridine 3-monooxygenase | False | 1 | 39 | 1 | 2 | 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O | 2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating) | None | 2,6-dihydroxypyridine oxidase | |
| 1.14.13.14 | trans-cinnamate 2-monooxygenase | False | 0 | 2 | 0 | 2 | trans-cinnamate + NADPH + H+ + O2 = 2-hydroxycinnamate + NADP+ + H2O | trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating) | None | cinnamic acid 2-hydroxylase; cinnamate 2-monooxygenase; cinnamic 2-hydroxylase; cinnamate 2-hydroxylase; trans-cinnamic acid 2-hydroxylase | |
| 1.14.13.16 | cyclopentanone monooxygenase | False | 1 | 13 | 0 | 3 | cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O | cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing) | None | cyclopentanone oxygenase | |
| 1.14.13.18 | 4-hydroxyphenylacetate 1-monooxygenase | False | 0 | 2 | 0 | 5 | 4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = homogentisate + NAD(P)+ + H2O | 4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating) | None | 4-hydroxyphenylacetate 1-hydroxylase; 4-hydroxyphenylacetic 1-hydroxylase; 4-HPA 1-hydroxylase | |
| 1.14.13.19 | taxifolin 8-monooxygenase | False | 0 | 3 | 0 | 1 | taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O | taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating) | None | taxifolin hydroxylase | |
| 1.14.13.20 | 2,4-dichlorophenol 6-monooxygenase | False | 2 | 382 | 0 | 16 | 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O | 2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating) | None | 2,4-dichlorophenol hydroxylase; 2,4-dichlorophenol monooxygenase | |
| 1.14.13.22 | cyclohexanone monooxygenase | False | 1 | 595 | 11 | 19 | cyclohexanone + NADPH + H+ + O2 = hexano-6-lactone + NADP+ + H2O | cyclohexanone,NADPH:oxygen oxidoreductase (lactone-forming) | None | cyclohexanone 1,2-monooxygenase; cyclohexanone oxygenase; cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) | |
| 1.14.13.23 | 3-hydroxybenzoate 4-monooxygenase | False | 1 | 34 | 2 | 3 | 3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O | 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating) | None | 3-hydroxybenzoate 4-hydroxylase | |
| 1.14.13.24 | 3-hydroxybenzoate 6-monooxygenase | False | 5 | 1690 | 0 | 12 | 3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O | 3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating) | None | 3-hydroxybenzoate 6-hydroxylase; m-hydroxybenzoate 6-hydroxylase; 3-hydroxybenzoic acid-6-hydroxylase | |
| 1.14.13.25 | methane monooxygenase (soluble) | False | 8 | 316 | 40 | 15 | methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O | methane,NAD(P)H:oxygen oxidoreductase (hydroxylating) | None | methane hydroxylase | |
| 1.14.13.27 | 4-aminobenzoate 1-monooxygenase | False | 0 | 1 | 0 | 1 | 4-aminobenzoate + NAD(P)H + 2 H+ + O2 = 4-hydroxyaniline + NAD(P)+ + H2O + CO2 | 4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | None | 4-aminobenzoate hydroxylase; 4-aminobenzoate monooxygenase | |
| 1.14.13.29 | 4-nitrophenol 2-monooxygenase | False | 3 | 57 | 0 | 14 | 4-nitrophenol + NADH + H+ + O2 = 4-nitrocatechol + NAD+ + H2O | 4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating) | None | 4-nitrophenol hydroxylase; 4-nitrophenol-2-hydroxylase | |
| 1.14.13.31 | 2-nitrophenol 2-monooxygenase | False | 0 | 1 | 0 | 3 | 2-nitrophenol + 2 NADPH + 2 H+ + O2 = catechol + nitrite + 2 NADP+ + H2O | 2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming) | None | 2-nitrophenol oxygenase; nitrophenol oxygenase | |
| 1.14.13.32 | albendazole monooxygenase | False | 9 | 218 | 2 | 5 | albendazole + NADPH + H+ + O2 = albendazole S-oxide + NADP+ + H2O | albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming) | None | albendazole oxidase (misleading); albendazole sulfoxidase (ambiguous); FMO3 (gene name); albendazole monooxygenase (flavin-containing) | |
| 1.14.13.33 | 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] | False | 3 | 59 | 1 | 4 | 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O | 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating) | None | 4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate)); 4-hydroxybenzoate-3-hydroxylase; 4-hydroxybenzoate 3-hydroxylase | |
| 1.14.13.34 | leukotriene-E4 20-monooxygenase | True | 0 | 0 | 0 | 1 | (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O | (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating) | None | leukotriene-E4 omega-hydroxylase | |
| 1.14.13.35 | anthranilate 3-monooxygenase (deaminating) | True | 0 | 0 | 0 | 2 | anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3 | anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating) | None | anthranilate hydroxylase; anthranilate 2,3-dioxygenase (deaminating); anthranilate hydroxylase (deaminating); anthranilic hydroxylase; anthranilate 2,3-hydroxylase (deaminating) | |
| 1.14.13.38 | anhydrotetracycline 6-monooxygenase | False | 2 | 137 | 0 | 2 | anhydrotetracycline + NADPH + H+ + O2 = 12-dehydrotetracycline + NADP+ + H2O | anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating) | None | ATC oxygenase; anhydrotetracycline oxygenase; oxyS (gene name); anhydrotetracycline monooxygenase | |
| 1.14.13.39 | nitric-oxide synthase (NADPH) | False | 35 | 5264 | 655 | 29 | 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O (overall reaction);;(1a) 2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O ;;(1b) 2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O | L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | None | NOS (gene name); nitric oxide synthetase (ambiguous); endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase (ambiguous); NADPH-diaphorase (ambiguous) | |
| 1.14.13.40 | anthraniloyl-CoA monooxygenase | False | 0 | 241 | 0 | 2 | anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+ | anthraniloyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing) | None | anthraniloyl coenzyme A reductase; 2-aminobenzoyl-CoA monooxygenase/reductase | |
| 1.14.13.43 | questin monooxygenase | False | 1 | 0 | 0 | 1 | questin + NADPH + H+ + O2 = demethylsulochrin + NADP+ | questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening) | None | questin oxygenase | |
| 1.14.13.44 | 2-hydroxybiphenyl 3-monooxygenase | False | 0 | 2 | 5 | 2 | 2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O | 2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating) | None | None | |
| 1.14.13.46 | (-)-menthol monooxygenase | True | 0 | 0 | 0 | 1 | (-)-menthol + NADPH + H+ + O2 = p-menthane-3,8-diol + NADP+ + H2O | (-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating) | None | l-menthol monooxygenase | |
| 1.14.13.50 | pentachlorophenol monooxygenase | False | 1 | 695 | 2 | 7 | (1) pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O;;(2) 2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O | pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating) | None | pcpB (gene name); pentachlorophenol dechlorinase; pentachlorophenol dehalogenase; pentachlorophenol 4-monooxygenase; PCP hydroxylase; pentachlorophenol hydroxylase; PCB 4-monooxygenase; PCB4MO | |
| 1.14.13.51 | 6-oxocineole dehydrogenase | True | 0 | 0 | 0 | 1 | 6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + NADP+ + H2O | 6-oxocineole,NADPH:oxygen oxidoreductase | None | 6-oxocineole oxygenase | |
| 1.14.13.54 | ketosteroid monooxygenase | False | 0 | 0 | 4 | 4 | a ketosteroid + NADPH + H+ + O2 = a steroid ester/lactone + NADP+ + H2O (general reaction);;(1) progesterone + NADPH + H+ + O2 = testosterone acetate + NADP+ + H2O;;(2) androstenedione + NADPH + H+ + O2 = testololactone + NADP+ + H2O;;(3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 = androstenedione + acetate + NADP+ + H2O | ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing) | None | steroid-ketone monooxygenase; progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing); 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving); androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing) | |
| 1.14.13.58 | benzoyl-CoA 3-monooxygenase | False | 0 | 1 | 0 | 1 | benzoyl-CoA + NADPH + H+ + O2 = 3-hydroxybenzoyl-CoA + NADP+ + H2O | benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating) | None | benzoyl-CoA 3-hydroxylase | |
| 1.14.13.59 | L-lysine N6-monooxygenase (NADPH) | False | 6 | 5854 | 2 | 3 | L-lysine + NADPH + H+ + O2 = N6-hydroxy-L-lysine + NADP+ + H2O | L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating) | None | lysine N6-hydroxylase; L-lysine 6-monooxygenase (NADPH) (ambiguous) | |
| 1.14.13.61 | 2-hydroxyquinoline 8-monooxygenase | False | 0 | 1 | 3 | 1 | quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O | quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) | None | 2-oxo-1,2-dihydroquinoline 8-monooxygenase | |
| 1.14.13.62 | 4-hydroxyquinoline 3-monooxygenase | True | 0 | 0 | 0 | 1 | quinolin-4-ol + NADH + H+ + O2 = quinolin-3,4-diol + NAD+ + H2O | quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating) | None | quinolin-4(1H)-one 3-monooxygenase | |
| 1.14.13.63 | 3-hydroxyphenylacetate 6-hydroxylase | False | 1 | 10 | 0 | 4 | 3-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 2,5-dihydroxyphenylacetate + NAD(P)+ + H2O | 3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating) | None | 3-hydroxyphenylacetate 6-monooxygenase | |
| 1.14.13.64 | 4-hydroxybenzoate 1-hydroxylase | True | 0 | 0 | 0 | 1 | 4-hydroxybenzoate + NAD(P)H + 2 H+ + O2 = hydroquinone + NAD(P)+ + H2O + CO2 | 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | None | 4-hydroxybenzoate 1-monooxygenase | |
| 1.14.13.66 | 2-hydroxycyclohexanone 2-monooxygenase | True | 0 | 0 | 0 | 1 | 2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O | 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing) | None | None | |
| 1.14.13.69 | alkene monooxygenase | False | 3 | 4 | 0 | 9 | propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O | alkene,NADH:oxygen oxidoreductase | None | alkene epoxygenase; etnABCD (gene names); amoABCDE (gene names) | |
| 1.14.13.81 | magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase | False | 45 | 3502 | 0 | 53 | magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = 3,8-divinyl protochlorophyllide a + 3 NADP+ + 5 H2O (overall reaction);;(1a) magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O;;(1b) 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O;;(1c) 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 3,8-divinyl protochlorophyllide a + NADP+ + 2 H2O | magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating) | None | Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase | |
| 1.14.13.82 | vanillate monooxygenase | False | 2 | 796 | 0 | 9 | vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde | vanillate:oxygen oxidoreductase (demethylating) | None | 4-hydroxy-3-methoxybenzoate demethylase; vanillate demethylase | |
| 1.14.13.83 | precorrin-3B synthase | False | 1 | 1647 | 0 | 3 | precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O | precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating) | None | precorrin-3X synthase; CobG | |
| 1.14.13.84 | 4-hydroxyacetophenone monooxygenase | False | 1 | 785 | 0 | 2 | (4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O | (4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) | None | HAPMO | |
| 1.14.13.92 | phenylacetone monooxygenase | False | 1 | 348 | 13 | 4 | phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O | phenylacetone,NADPH:oxygen oxidoreductase | None | PAMO | |
| 1.14.14.1 | unspecific monooxygenase | False | 232 | 14187 | 340 | 51 | RH + [reduced NADPH---hemoprotein reductase] + O2 = ROH + [oxidized NADPH---hemoprotein reductase] + H2O | substrate,NADPH---hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | None | microsomal monooxygenase; xenobiotic monooxygenase; aryl-4-monooxygenase; aryl hydrocarbon hydroxylase; microsomal P-450; flavoprotein-linked monooxygenase; flavoprotein monooxygenase; substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 1.14.14.3 | bacterial luciferase | False | 19 | 1824 | 7 | 15 | a long-chain aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + H2O + hnu | long-chain-aldehyde,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing) | None | aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing) | |
| 1.14.14.5 | alkanesulfonate monooxygenase | False | 82 | 7439 | 5 | 1 | an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + sulfite + H2O | alkanesulfonate,FMNH2:oxygen oxidoreductase | None | SsuD; sulfate starvation-induced protein 6; alkanesulfonate,reduced-FMN:oxygen oxidoreductase | |
| 1.14.15.1 | camphor 5-monooxygenase | False | 1 | 55 | 122 | 3 | (+)-camphor + reduced putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O | (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating) | None | camphor 5-exo-methylene hydroxylase; 2-bornanone 5-exo-hydroxylase; bornanone 5-exo-hydroxylase; camphor 5-exo-hydroxylase; camphor 5-exohydroxylase; camphor hydroxylase; d-camphor monooxygenase; methylene hydroxylase; methylene monooxygenase; D-camphor-exo-hydroxylase; camphor methylene hydroxylase | |
| 1.14.15.3 | alkane 1-monooxygenase | False | 7 | 1169 | 2 | 53 | octane + 2 reduced rubredoxin + O2 + 2 H+ = 1-octanol + 2 oxidized rubredoxin + H2O | alkane,reduced-rubredoxin:oxygen 1-oxidoreductase | None | alkane 1-hydroxylase; omega-hydroxylase; fatty acid omega-hydroxylase; alkane monooxygenase; 1-hydroxylase; alkane hydroxylase | |
| 1.14.15.4 | steroid 11beta-monooxygenase | False | 14 | 811 | 5 | 16 | a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O | steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating) | None | steroid 11beta-hydroxylase; steroid 11beta/18-hydroxylase | |
| 1.14.15.5 | corticosterone 18-monooxygenase | False | 7 | 0 | 4 | 4 | corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O | corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating) | None | corticosterone 18-hydroxylase; corticosterone methyl oxidase | |
| 1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) | False | 13 | 1382 | 5 | 18 | cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O (overall reaction);;(1a) cholesterol + 2 reduced adrenodoxin + O2 + 2 H+ = (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O;;(1b) (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 + 2 H+ = (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O;;(1c) (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 + 2 H+ = pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O | cholesterol,reduced-adrenodoxin:oxygen oxidoreductase (side-chain-cleaving) | None | cholesterol desmolase; cytochrome P-450scc; C27-side chain cleavage enzyme; cholesterol 20-22-desmolase; cholesterol C20-22 desmolase; cholesterol side-chain cleavage enzyme; cholesterol side-chain-cleaving enzyme; steroid 20-22 desmolase; steroid 20-22-lyase; CYP11A1 (gene name) | |
| 1.14.15.7 | choline monooxygenase | False | 5 | 3440 | 0 | 15 | choline + O2 + 2 reduced ferredoxin + 2 H+ = betaine aldehyde hydrate + H2O + 2 oxidized ferredoxin | choline,reduced-ferredoxin:oxygen oxidoreductase | None | None | |
| 1.14.16.1 | phenylalanine 4-monooxygenase | False | 16 | 10876 | 46 | 23 | L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | L-phenylalanine,tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating) | None | phenylalaninase; phenylalanine 4-hydroxylase; phenylalanine hydroxylase | |
| 1.14.16.2 | tyrosine 3-monooxygenase | False | 12 | 1048 | 9 | 48 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | L-tyrosine,tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating) | None | L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase | |
| 1.14.16.4 | tryptophan 5-monooxygenase | False | 14 | 2029 | 24 | 33 | L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating) | None | L-tryptophan hydroxylase; indoleacetic acid-5-hydroxylase; tryptophan 5-hydroxylase; tryptophan hydroxylase | |
| 1.14.16.5 | alkylglycerol monooxygenase | False | 6 | 1912 | 0 | 12 | 1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | 1-alkyl-sn-glycerol,tetrahydrobiopteridine:oxygen oxidoreductase | None | glyceryl-ether monooxygenase; glyceryl-ether cleaving enzyme; glyceryl ether oxygenase; glyceryl etherase; O-alkylglycerol monooxygenase | |
| 1.14.16.6 | mandelate 4-monooxygenase | True | 0 | 0 | 0 | 1 | (S)-2-hydroxy-2-phenylacetate + a 5,6,7,8-tetrahydropteridine + O2 = (S)-4-hydroxymandelate + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | (S)-2-hydroxy-2-phenylacetate,tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating) | None | L-mandelate 4-hydroxylase; mandelic acid 4-hydroxylase | |
| 1.14.17.1 | dopamine beta-monooxygenase | False | 6 | 923 | 4 | 13 | dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O | dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) | None | dopamine beta-hydroxylase; MDBH (membrane-associated dopamine beta-monooxygenase); SDBH (soluble dopamine beta-monooxygenase); dopamine-B-hydroxylase; 3,4-dihydroxyphenethylamine beta-oxidase; 4-(2-aminoethyl)pyrocatechol beta-oxidase; dopa beta-hydroxylase; dopamine beta-oxidase; dopamine hydroxylase; phenylamine beta-hydroxylase; (3,4-dihydroxyphenethylamine)beta-mono-oxygenase; DbetaM (gene name) | |
| 1.14.17.3 | peptidylglycine monooxygenase | False | 9 | 697 | 32 | 16 | [peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | [peptide]-glycine,ascorbate:oxygen oxidoreductase (2-hydroxylating) | None | peptidylglycine 2-hydroxylase; peptidyl alpha-amidating enzyme; peptide-alpha-amide synthetase; peptide alpha-amidating enzyme; peptide alpha-amide synthase; peptidylglycine alpha-hydroxylase; peptidylglycine alpha-amidating monooxygenase; PAM-A; PAM-B; PAM; peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating) | |
| 1.14.17.4 | aminocyclopropanecarboxylate oxidase | False | 31 | 1501 | 6 | 38 | 1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethene + cyanide + dehydroascorbate + CO2 + 2 H2O | 1-aminocyclopropane-1-carboxylate oxygenase (ethene-forming) | None | ACC oxidase; ethylene-forming enzyme; 1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming) | |
| 1.14.18.1 | tyrosinase | False | 38 | 10112 | 68 | 169 | (1) L-tyrosine + O2 = dopaquinone + H2O (overall reaction);;(1a) L-tyrosine + 1/2 O2 = L-dopa;;(1b) L-dopa + 1/2 O2 = dopaquinone + H2O;;(2) 2 L-dopa + O2 = 2 dopaquinone + 2 H2O | L-tyrosine,L-dopa:oxygen oxidoreductase | None | monophenol monooxygenase; phenolase; monophenol oxidase; cresolase; monophenolase; tyrosine-dopa oxidase; monophenol monooxidase; monophenol dihydroxyphenylalanine:oxygen oxidoreductase; N-acetyl-6-hydroxytryptophan oxidase; monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase; o-diphenol:O2 oxidoreductase; phenol oxidase | |
| 1.14.18.2 | CMP-N-acetylneuraminate monooxygenase | False | 11 | 912 | 0 | 12 | CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+ = CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O | CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) | None | CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; cytidine monophosphoacetylneuraminate monooxygenase; N-acetylneuraminic monooxygenase; cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase | |
| 1.14.19.1 | stearoyl-CoA 9-desaturase | False | 21 | 4895 | 3 | 31 | stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating) | None | Delta9-desaturase; acyl-CoA desaturase; fatty acid desaturase; stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase | |
| 1.14.19.2 | stearoyl-[acyl-carrier-protein] 9-desaturase | False | 30 | 988 | 8 | 35 | stearoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = oleoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | stearoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating) | None | stearyl acyl carrier protein desaturase; stearyl-ACP desaturase; acyl-[acyl-carrier-protein] desaturase; acyl-[acyl-carrier protein],hydrogen-donor:oxygen oxidoreductase | |
| 1.14.19.3 | acyl-CoA 6-desaturase | False | 11 | 712 | 0 | 44 | (1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O;;(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O | acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) | None | Delta6-desaturase; Delta6-fatty acyl-CoA desaturase; Delta6-acyl CoA desaturase; fatty acid Delta6-desaturase; fatty acid 6-desaturase; linoleate desaturase; linoleic desaturase; linoleic acid desaturase; linoleoyl CoA desaturase; linoleoyl-coenzyme A desaturase; long-chain fatty acid Delta6-desaturase; linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase; linoleoyl-CoA desaturase; FADS2 (gene name) | |
| 1.14.20.1 | deacetoxycephalosporin-C synthase | False | 3 | 8 | 9 | 6 | penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O | penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding) | None | DAOCS; penicillin N expandase; DAOC synthase | |
| 1.14.99.1 | prostaglandin-endoperoxide synthase | False | 17 | 2889 | 88 | 16 | arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O | (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase | None | prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase | |
| 1.14.99.2 | kynurenine 7,8-hydroxylase | False | 0 | 1 | 0 | 2 | kynurenate + reduced acceptor + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor | kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating) | None | kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase | |
| 1.14.99.4 | progesterone monooxygenase | False | 0 | 1 | 0 | 11 | progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O | progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating) | None | progesterone hydroxylase | |
| 1.14.99.11 | estradiol 6beta-monooxygenase | True | 0 | 0 | 0 | 2 | estradiol-17beta + reduced acceptor + O2 = 6beta-hydroxyestradiol-17beta + acceptor + H2O | estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating) | None | estradiol 6beta-hydroxylase | |
| 1.14.99.12 | androst-4-ene-3,17-dione monooxygenase | True | 0 | 0 | 0 | 7 | androstenedione + reduced acceptor + O2 = testololactone + acceptor + H2O | androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing) | None | androstene-3,17-dione hydroxylase; androst-4-ene-3,17-dione 17-oxidoreductase; androst-4-ene-3,17-dione hydroxylase; androstenedione monooxygenase; 4-androstene-3,17-dione monooxygenase | |
| 1.14.99.14 | progesterone 11alpha-monooxygenase | True | 0 | 0 | 0 | 8 | progesterone + reduced acceptor + O2 = 11alpha-hydroxyprogesterone + acceptor + H2O | progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating) | None | progesterone 11alpha-hydroxylase | |
| 1.14.99.15 | 4-methoxybenzoate monooxygenase (O-demethylating) | False | 1 | 24 | 0 | 2 | 4-methoxybenzoate + reduced acceptor + O2 = 4-hydroxybenzoate + formaldehyde + acceptor + H2O | 4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating) | None | 4-methoxybenzoate 4-monooxygenase (O-demethylating); 4-methoxybenzoate O-demethylase; p-anisic O-demethylase; piperonylate-4-O-demethylase | |
| 1.14.99.20 | phylloquinone monooxygenase (2,3-epoxidizing) | False | 0 | 1 | 0 | 4 | phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O | phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing) | None | phylloquinone epoxidase; vitamin K 2,3-epoxidase; vitamin K epoxidase; vitamin K1 epoxidase | |
| 1.14.99.21 | Latia-luciferin monooxygenase (demethylating) | True | 0 | 0 | 0 | 1 | Latia luciferin + reduced acceptor + 2 O2 = oxidized Latia luciferin + CO2 + formate + acceptor + H2O + hnu | Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating) | None | luciferase (Latia luciferin); Latia luciferin monooxygenase (demethylating) | |
| 1.14.99.22 | ecdysone 20-monooxygenase | False | 1 | 9 | 0 | 14 | ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O | Ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating) | None | alpha-ecdysone C-20 hydroxylase; ecdysone 20-hydroxylase | |
| 1.14.99.23 | 3-hydroxybenzoate 2-monooxygenase | True | 0 | 0 | 0 | 2 | 3-hydroxybenzoate + reduced acceptor + O2 = 2,3-dihydroxybenzoate + acceptor + H2O | 3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating) | None | 3-hydroxybenzoate 2-hydroxylase; 3-HBA-2-hydroxylase | |
| 1.14.99.24 | steroid 9alpha-monooxygenase | True | 0 | 0 | 0 | 11 | pregna-4,9(11)-diene-3,20-dione + reduced acceptor + O2 = 9,11alpha-epoxypregn-4-ene-3,20-dione + acceptor + H2O | steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing) | None | steroid 9alpha-hydroxylase | |
| 1.14.99.26 | 2-hydroxypyridine 5-monooxygenase | True | 0 | 0 | 0 | 1 | 2-hydroxypyridine + reduced acceptor + O2 = 2,5-dihydroxypyridine + acceptor + H2O | 2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating) | None | 2-hydroxypyridine oxygenase | |
| 1.14.99.29 | deoxyhypusine monooxygenase | False | 40 | 3478 | 2 | 13 | [eIF5A]-deoxyhypusine + reduced acceptor + O2 = [eIF5A]-hypusine + acceptor + H2O | deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating) | None | deoxyhypusine hydroxylase; deoxyhypusine dioxygenase | |
| 1.14.99.34 | monoprenyl isoflavone epoxidase | True | 0 | 0 | 0 | 1 | 7-O-methylluteone + NADPH + H+ + O2 = dihydrofurano derivatives + NADP+ + H2O | 7-O-methylluteone,NADPH:oxygen oxidoreductase | None | monoprenyl isoflavone monooxygenase; 7-O-methylluteone:O2 oxidoreductase; 7-O-methylluteone,NADPH:O2 oxidoreductase | |
| 1.14.99.35 | thiophene-2-carbonyl-CoA monooxygenase | True | 0 | 0 | 0 | 1 | thiophene-2-carbonyl-CoA + reduced acceptor + O2 = 5-hydroxythiophene-2-carbonyl-CoA + acceptor + H2O | thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase | None | thiophene-2-carboxyl-CoA dehydrogenase; thiophene-2-carboxyl-CoA hydroxylase; thiophene-2-carboxyl-CoA monooxygenase | |
| 1.14.99.38 | cholesterol 25-monooxygenase | False | 5 | 771 | 1 | 10 | cholesterol + reduced acceptor + O2 = 25-hydroxycholesterol + acceptor + H2O | cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) | None | cholesterol 25-hydroxylase (ambiguous) | |
| 1.15.1.1 | superoxide dismutase | False | 455 | 74631 | 443 | 236 | 2 superoxide + 2 H+ = O2 + H2O2 | superoxide:superoxide oxidoreductase | None | superoxidase dismutase; copper-zinc superoxide dismutase; Cu-Zn superoxide dismutase; ferrisuperoxide dismutase; superoxide dismutase I; superoxide dismutase II; SOD; Cu,Zn-SOD; Mn-SOD; Fe-SOD; SODF; SODS; SOD-1; SOD-2; SOD-3; SOD-4; hemocuprein; erythrocuprein; cytocuprein; cuprein; hepatocuprein | |
| 1.15.1.2 | superoxide reductase | False | 14 | 3690 | 14 | 19 | superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin | rubredoxin:superoxide oxidoreductase | None | neelaredoxin; desulfoferrodoxin | |
| 1.16.1.1 | mercury(II) reductase | False | 14 | 6072 | 8 | 63 | Hg + NADP+ + H+ = Hg2+ + NADPH | Hg:NADP+ oxidoreductase | None | mercuric reductase; mercurate(II) reductase; mercuric ion reductase; mercury reductase; reduced NADP:mercuric ion oxidoreductase; mer A | |
| 1.16.1.2 | diferric-transferrin reductase | False | 0 | 0 | 3 | 4 | transferrin[Fe(II)]2 + NAD+ + H+ = transferrin[Fe(III)]2 + NADH | transferrin[Fe(II)]2:NAD+ oxidoreductase | None | diferric transferrin reductase; NADH diferric transferrin reductase; transferrin reductase | |
| 1.16.1.6 | cyanocobalamin reductase | False | 5 | 808 | 0 | 1 | 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP+ = 2 cyanocob(III)alamin + 2 [cyanocobalamin reductase] + NADPH + H+ | cob(II)alamin, hydrogen cyanide:NADP+ oxidoreductase | None | MMACHC (gene name); CblC; cyanocobalamin reductase (NADPH, cyanide-eliminating); cyanocobalamin reductase (NADPH, CN-eliminating); NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating); cob(I)alamin, cyanide:NADP+ oxidoreductase; cyanocobalamin reductase (cyanide-eliminating) | |
| 1.16.1.7 | ferric-chelate reductase (NADH) | False | 17 | 129 | 0 | 22 | 2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH | Fe(II)-siderophore:NAD+ oxidoreductase | None | ferric chelate reductase (ambiguous); iron chelate reductase (ambiguous); NADH:Fe3+-EDTA reductase; NADH2:Fe3+ oxidoreductase; ferB (gene name); Fe(II):NAD+ oxidoreductase | |
| 1.16.1.8 | [methionine synthase] reductase | False | 5 | 1430 | 2 | 3 | 2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine | [methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase | None | methionine synthase cob(II)alamin reductase (methylating); methionine synthase reductase; [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing); [methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase | |
| 1.16.3.1 | ferroxidase | False | 120 | 25734 | 302 | 41 | 4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O | Fe(II):oxygen oxidoreductase | None | ceruloplasmin; caeruloplasmin; ferroxidase I; iron oxidase; iron(II):oxygen oxidoreductase; ferro:O2 oxidoreductase; iron II:oxygen oxidoreductase; hephaestin; HEPH | |
| 1.17.1.1 | CDP-4-dehydro-6-deoxyglucose reductase | False | 0 | 182 | 0 | 2 | CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+ | CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase | None | CDP-4-keto-6-deoxyglucose reductase; cytidine diphospho-4-keto-6-deoxy-D-glucose reductase; cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase; CDP-4-keto-deoxy-glucose reductase; CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system; NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase | |
| 1.17.1.3 | leucoanthocyanidin reductase | False | 1 | 44 | 4 | 20 | (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+ | (2R,3S)-catechin:NADP+ 4-oxidoreductase | None | leucocyanidin reductase | |
| 1.17.1.4 | xanthine dehydrogenase | False | 24 | 15946 | 32 | 66 | xanthine + NAD+ + H2O = urate + NADH + H+ | xanthine:NAD+ oxidoreductase | None | NAD+-xanthine dehydrogenase; xanthine-NAD+ oxidoreductase; xanthine/NAD+ oxidoreductase; xanthine oxidoreductase | |
| 1.17.1.5 | nicotinate dehydrogenase | False | 4 | 1050 | 0 | 13 | nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH + H+ | nicotinate:NADP+ 6-oxidoreductase (hydroxylating) | None | nicotinic acid hydroxylase; nicotinate hydroxylase | |
| 1.17.3.1 | pteridine oxidase | True | 0 | 0 | 0 | 1 | 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + (?) | 2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating) | None | None | |
| 1.17.3.2 | xanthine oxidase | False | 6 | 912 | 2 | 35 | xanthine + H2O + O2 = urate + H2O2 | xanthine:oxygen oxidoreductase | None | hypoxanthine oxidase; hypoxanthine:oxygen oxidoreductase; Schardinger enzyme; xanthine oxidoreductase; hypoxanthine-xanthine oxidase; xanthine:O2 oxidoreductase; xanthine:xanthine oxidase | |
| 1.20.2.1 | arsenate reductase (cytochrome c) | False | 0 | 3 | 0 | 5 | arsenite + H2O + 2 oxidized cytochrome c = arsenate + 2 reduced cytochrome c + 2 H+ | arsenite:cytochrome c oxidoreductase | None | arsenite oxidase (ambiguous) | |
| 1.17.3.3 | 6-hydroxynicotinate dehydrogenase | True | 0 | 0 | 0 | 2 | 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 | 6-hydroxynicotinate:oxygen oxidoreductase | None | 6-hydroxynicotinic acid hydroxylase; 6-hydroxynicotinic acid dehydrogenase; 6-hydroxynicotinate hydroxylase; 6-hydroxynicotinate:O2 oxidoreductase | |
| 1.17.4.1 | ribonucleoside-diphosphate reductase | False | 188 | 97467 | 231 | 40 | 2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin | 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | None | ribonucleotide reductase (ambiguous); CDP reductase; ribonucleoside diphosphate reductase; UDP reductase; ADP reductase; nucleoside diphosphate reductase; ribonucleoside 5'-diphosphate reductase; ribonucleotide diphosphate reductase; 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase; RR; nrdB (gene name); nrdF (gene name); nrdJ (gene name) | |
| 1.17.4.2 | ribonucleoside-triphosphate reductase (thioredoxin) | False | 14 | 13596 | 12 | 45 | 2'-deoxyribonucleoside 5'-triphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-triphosphate + thioredoxin | 2'-deoxyribonucleoside-5'-triphosphate:thioredoxin-disulfide 2'-oxidoreductase | None | ribonucleotide reductase (ambiguous); 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase | |
| 1.17.5.1 | phenylacetyl-CoA dehydrogenase | False | 0 | 7 | 0 | 1 | phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol | phenylacetyl-CoA:quinone oxidoreductase | None | phenylacetyl-CoA:acceptor oxidoreductase | |
| 1.17.99.2 | ethylbenzene hydroxylase | False | 0 | 1 | 1 | 3 | ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor | ethylbenzene:acceptor oxidoreductase | None | ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase | |
| 1.17.99.3 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase | False | 4 | 2 | 0 | 3 | (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor | (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) | None | trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase | |
| 1.18.1.1 | rubredoxin---NAD+ reductase | False | 6 | 495 | 2 | 7 | 2 reduced rubredoxin + NAD+ + H+ = 2 oxidized rubredoxin + NADH | rubredoxin:NAD+ oxidoreductase | None | rubredoxin reductase; rubredoxin-nicotinamide adenine dinucleotide reductase; dihydronicotinamide adenine dinucleotide-rubredoxin reductase; reduced nicotinamide adenine dinucleotide-rubredoxin reductase; NADH-rubredoxin reductase; rubredoxin-NAD reductase; NADH: rubredoxin oxidoreductase; DPNH-rubredoxin reductase; NADH-rubredoxin oxidoreductase | |
| 1.18.1.2 | ferredoxin---NADP+ reductase | False | 267 | 36870 | 116 | 57 | 2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH | ferredoxin:NADP+ oxidoreductase | None | ferredoxin-nicotinamide adenine dinucleotide phosphate reductase; ferredoxin-NADP+ reductase; TPNH-ferredoxin reductase; ferredoxin-NADP+ oxidoreductase; NADP+:ferredoxin oxidoreductase; ferredoxin-TPN reductase; ferredoxin-NADP+-oxidoreductase; NADPH:ferredoxin oxidoreductase; ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase | |
| 1.18.1.3 | ferredoxin---NAD+ reductase | False | 39 | 1808 | 16 | 24 | (1) 2 reduced [2Fe-2S] ferredoxin + NAD+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NADH;;(2) reduced 2[4Fe-4S] ferredoxin + NAD+ + H+ = oxidized 2[4Fe-4S] ferredoxin + NADH | ferredoxin:NAD+ oxidoreductase | None | ferredoxin-nicotinamide adenine dinucleotide reductase; ferredoxin reductase (ambiguous); NAD+-ferredoxin reductase; NADH-ferredoxin oxidoreductase; reductase, reduced nicotinamide adenine dinucleotide-ferredoxin; ferredoxin-NAD+ reductase; NADH-ferredoxin reductase; NADH2-ferredoxin oxidoreductase; NADH flavodoxin oxidoreductase; NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system); ferredoxin-linked NAD+ reductase; NADH-ferredoxin TOL reductase (component of toluene dioxygenase); ferredoxin---NAD reductase | |
| 1.18.1.4 | rubredoxin---NAD(P)+ reductase | False | 1 | 0 | 0 | 2 | 2 reduced rubredoxin + NAD(P)+ + H+ = 2 oxidized rubredoxin + NAD(P)H | rubredoxin:NAD(P)+ oxidoreductase | None | rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase; rubredoxin-nicotinamide adenine; dinucleotide phosphate reductase; NAD(P)+-rubredoxin oxidoreductase; NAD(P)H-rubredoxin oxidoreductase | |
| 1.18.6.1 | nitrogenase | False | 192 | 18337 | 119 | 53 | 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate | ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing, molybdenum-dependent) | None | reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) | |
| 1.19.6.1 | nitrogenase (flavodoxin) | True | 0 | 0 | 0 | 7 | 4 reduced flavodoxin + N2 + 16 ATP + 16 H2O = 4 oxidized flavodoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate | reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing) | None | None | |
| 1.20.1.1 | phosphonate dehydrogenase | False | 1 | 107 | 2 | 7 | phosphonate + NAD+ + H2O = phosphate + NADH + H+ | phosphonate:NAD+ oxidoreductase | None | NAD:phosphite oxidoreductase; phosphite dehydrogenase | |
| 1.20.4.1 | arsenate reductase (glutathione/glutaredoxin) | False | 19 | 18203 | 30 | 13 | arsenate + glutathione + glutaredoxin = arsenite + a glutaredoxin-glutathione disulfide + H2O | arsenate:glutathione/glutaredoxin oxidoreductase | None | ArsC (ambiguous); arsenate:glutaredoxin oxidoreductase; arsenate reductase (glutaredoxin) | |
| 1.20.4.4 | arsenate reductase (thioredoxin) | False | 39 | 2362 | 0 | 7 | arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O | arsenate:thioredoxin oxidoreductase | None | ArsC (ambiguous) | |
| 1.20.4.2 | methylarsonate reductase | False | 11 | 1796 | 0 | 3 | methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O | methylarsonate:glutathione oxidoreductase | None | MMA(V) reductase | |
| 1.20.99.1 | arsenate reductase (donor) | False | 2 | 4 | 0 | 32 | arsenite + acceptor = arsenate + reduced acceptor | arsenate:acceptor oxidoreductase | None | arsenate:(acceptor) oxidoreductase | |
| 1.21.3.1 | isopenicillin-N synthase | False | 12 | 55 | 70 | 16 | N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O | N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing) | None | isopenicillin N synthetase | |
| 1.21.3.2 | columbamine oxidase | True | 0 | 0 | 0 | 1 | 2 columbamine + O2 = 2 berberine + 2 H2O | columbamine:oxygen oxidoreductase (cyclizing) | None | berberine synthase | |
| 1.21.3.3 | reticuline oxidase | False | 2 | 40 | 10 | 9 | (S)-reticuline + O2 = (S)-scoulerine + H2O2 | (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) | None | BBE; berberine bridge enzyme; berberine-bridge-forming enzyme; tetrahydroprotoberberine synthase | |
| 1.21.3.4 | sulochrin oxidase [(+)-bisdechlorogeodin-forming] | True | 0 | 0 | 0 | 1 | 2 sulochrin + O2 = 2 (+)-bisdechlorogeodin + 2 H2O | sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific) | None | sulochrin oxidase | |
| 1.21.3.5 | sulochrin oxidase [(-)-bisdechlorogeodin-forming] | True | 0 | 0 | 0 | 1 | 2 sulochrin + O2 = 2 (-)-bisdechlorogeodin + 2 H2O | sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific) | None | sulochrin oxidase | |
| 1.21.3.6 | aureusidin synthase | False | 1 | 2 | 0 | 2 | (1) 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + O2 = aureusidin 6-O-beta-D-glucoside + H2O;;(2) 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 1/2 O2 = aureusidin 6-O-beta-D-glucoside + H2O;;(3) 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + O2 = bracteatin 6-O-beta-D-glucoside + H2O | 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside:oxygen oxidoreductase | None | AmAS1 | |
| 1.21.4.1 | D-proline reductase | False | 2 | 660 | 0 | 3 | 5-aminopentanoate + a [PrdC protein with a selenide-sulfide bridge] = D-proline + a [PrdC protein with thiol/selenol residues] | 5-aminopentanoate:[PrdC protein] oxidoreductase (cyclizing) | None | prdAB (gene names); D-proline reductase (dithiol) | |
| 1.21.4.2 | glycine reductase | False | 22 | 1527 | 0 | 8 | acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin | acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming) | None | None | |
| 1.21.4.3 | sarcosine reductase | False | 17 | 466 | 0 | 7 | acetyl phosphate + methylamine + thioredoxin disulfide + H2O = N-methylglycine + phosphate + thioredoxin | acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) | None | None | |
| 1.21.4.4 | betaine reductase | False | 17 | 581 | 0 | 1 | acetyl phosphate + trimethylamine + thioredoxin disulfide + H2O = betaine + phosphate + thioredoxin | acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (betaine-forming) | None | acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) | |
| 1.21.99.1 | beta-cyclopiazonate dehydrogenase | False | 3 | 0 | 0 | 1 | beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor | beta-cyclopiazonate:acceptor oxidoreductase (cyclizing) | None | beta-cyclopiazonate oxidocyclase; beta-cyclopiazonic oxidocyclase; beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing) | |
| 1.97.1.1 | chlorate reductase | False | 2 | 19 | 1 | 41 | reduced acceptor + chlorate = acceptor + H2O + chlorite | chlorite:acceptor oxidoreductase | None | chlorate reductase C | |
| 1.97.1.2 | pyrogallol hydroxytransferase | False | 2 | 88 | 3 | 2 | 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene | 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase | None | 1,2,3,5-tetrahydroxybenzene hydroxyltransferase; 1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase; 1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase); pyrogallol hydroxyltransferase; 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase | |
| 1.97.1.4 | [formate-C-acetyltransferase]-activating enzyme | False | 23 | 10991 | 5 | 8 | S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical | [formate C-acetyltransferase]-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) | None | PFL activase; PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving); formate acetyltransferase activating enzyme; formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving); pyruvate formate-lyase activating enzyme; pyruvate formate-lyase 1 activating enzyme | |
| 1.97.1.9 | selenate reductase (cytochrome c) | False | 3 | 151 | 0 | 17 | 2 ferricytochrome c + selenite + H2O = 2 ferrocytochrome c + selenate | ferricytochrome c:selenite oxidoreductase | None | serA (gene name); serB (gene name); serC (gene name); selenite:reduced acceptor oxidoreductase; selenate reductase | |
| 2.1.1.1 | nicotinamide N-methyltransferase | False | 4 | 60 | 19 | 7 | S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide | S-adenosyl-L-methionine:nicotinamide N-methyltransferase | None | nicotinamide methyltransferase | |
| 2.1.1.2 | guanidinoacetate N-methyltransferase | False | 8 | 413 | 7 | 9 | S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine | S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase | None | GA methylpherase; guanidinoacetate methyltransferase; guanidinoacetate transmethylase; methionine-guanidinoacetic transmethylase; guanidoacetate methyltransferase | |
| 2.1.1.3 | thetin---homocysteine S-methyltransferase | False | 0 | 1 | 0 | 1 | dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine | dimethylsulfonioacetate:L-homocysteine S-methyltransferase | None | dimethylthetin-homocysteine methyltransferase; thetin-homocysteine methylpherase | |
| 2.1.1.4 | acetylserotonin O-methyltransferase | False | 14 | 1010 | 2 | 18 | S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin | S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase | None | hydroxyindole methyltransferase; hydroxyindole O-methyltransferase; N-acetylserotonin O-methyltransferase; acetylserotonin methyltransferase | |
| 2.1.1.5 | betaine---homocysteine S-methyltransferase | False | 9 | 1206 | 5 | 13 | betaine + L-homocysteine = dimethylglycine + L-methionine | trimethylammonioacetate:L-homocysteine S-methyltransferase | None | betaine-homocysteine methyltransferase; betaine-homocysteine transmethylase | |
| 2.1.1.6 | catechol O-methyltransferase | False | 19 | 4155 | 117 | 22 | S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol | S-adenosyl-L-methionine:catechol O-methyltransferase | None | COMT I ; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase | |
| 2.1.1.7 | nicotinate N-methyltransferase | False | 3 | 2 | 1 | 5 | S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate | S-adenosyl-L-methionine:nicotinate N-methyltransferase | None | furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyltransferase | |
| 2.1.1.8 | histamine N-methyltransferase | False | 11 | 275 | 7 | 9 | S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine | S-adenosyl-L-methionine:histamine N-tele-methyltransferase | None | histamine 1-methyltransferase; histamine methyltransferase; histamine-methylating enzyme; imidazolemethyltransferase; S-adenosylmethionine-histamine N-methyltransferase | |
| 2.1.1.9 | thiol S-methyltransferase | False | 7 | 9 | 0 | 18 | S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether | S-adenosyl-L-methionine:thiol S-methyltransferase | None | S-methyltransferase; thiol methyltransferase; TMT | |
| 2.1.1.10 | homocysteine S-methyltransferase | False | 17 | 4880 | 3 | 12 | S-methyl-L-methionine + L-homocysteine = 2 L-methionine | S-methyl-L-methionine:L-homocysteine S-methyltransferase | None | S-adenosylmethionine homocysteine transmethylase; S-methylmethionine homocysteine transmethylase; adenosylmethionine transmethylase; methylmethionine:homocysteine methyltransferase; adenosylmethionine:homocysteine methyltransferase; homocysteine methylase; homocysteine methyltransferase; homocysteine transmethylase; L-homocysteine S-methyltransferase; S-adenosyl-L-methionine:L-homocysteine methyltransferase; S-adenosylmethionine-homocysteine transmethylase; S-adenosylmethionine:homocysteine methyltransferase | |
| 2.1.1.11 | magnesium protoporphyrin IX methyltransferase | False | 3 | 2009 | 2 | 13 | S-adenosyl-L-methionine + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester | S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase | None | None | |
| 2.1.1.12 | methionine S-methyltransferase | False | 4 | 518 | 0 | 15 | S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine | S-adenosyl-L-methionine:L-methionine S-methyltransferase | None | S-adenosyl methionine:methionine methyl transferase; methionine methyltransferase; S-adenosylmethionine transmethylase; S-adenosylmethionine-methionine methyltransferase | |
| 2.1.1.13 | methionine synthase | False | 20 | 34432 | 25 | 27 | 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase | None | 5-methyltetrahydrofolate---homocysteine S-methyltransferase; 5-methyltetrahydrofolate---homocysteine transmethylase; N-methyltetrahydrofolate:L-homocysteine methyltransferase; N5-methyltetrahydrofolate methyltransferase; N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase; N5-methyltetrahydrofolic---homocysteine vitamin B12 transmethylase; B12 N5-methyltetrahydrofolate homocysteine methyltransferase; methyltetrahydrofolate---homocysteine vitamin B12 methyltransferase; tetrahydrofolate methyltransferase; tetrahydropteroylglutamate methyltransferase; tetrahydropteroylglutamic methyltransferase; vitamin B12 methyltransferase; cobalamin-dependent methionine synthase; methionine synthase (cobalamin-dependent); MetH | |
| 2.1.1.14 | 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase | False | 277 | 20620 | 27 | 26 | 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine | 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase | None | tetrahydropteroyltriglutamate methyltransferase; homocysteine methylase; methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase; methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase; cobalamin-independent methionine synthase; methionine synthase (cobalamin-independent); MetE | |
| 2.1.1.15 | fatty-acid O-methyltransferase | False | 1 | 1 | 0 | 5 | S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester | S-adenosyl-L-methionine:fatty-acid O-methyltransferase | None | fatty acid methyltransferase; fatty acid O-methyltransferase | |
| 2.1.1.16 | methylene-fatty-acyl-phospholipid synthase | False | 0 | 4 | 0 | 1 | S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid | S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating) | None | unsaturated-phospholipid methyltransferase | |
| 2.1.1.17 | phosphatidylethanolamine N-methyltransferase | False | 69 | 2796 | 0 | 17 | S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase | None | PEMT; LMTase; lipid methyl transferase; phosphatidylethanolamine methyltransferase; phosphatidylethanolamine-N-methylase; phosphatidylethanolamine-S-adenosylmethionine methyltransferase | |
| 2.1.1.18 | polysaccharide O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + a (1->4)-alpha-D-glucooligosaccharide = S-adenosyl-L-homocysteine + an oligosaccharide containing 6-methyl-D-glucose units | S-adenosyl-L-methionine:(1->4)-alpha-D-glucan 6-O-methyltransferase | None | polysaccharide methyltransferase; acylpolysacharide 6-methyltransferase; S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase | |
| 2.1.1.19 | trimethylsulfonium---tetrahydrofolate N-methyltransferase | False | 0 | 1 | 0 | 1 | trimethylsulfonium + tetrahydrofolate = dimethylsulfide + 5-methyltetrahydrofolate | trimethylsulfonium:tetrahydrofolate N-methyltransferase | None | trimethylsulfonium-tetrahydrofolate methyltransferase | |
| 2.1.1.20 | glycine N-methyltransferase | False | 5 | 1219 | 14 | 8 | S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine | S-adenosyl-L-methionine:glycine N-methyltransferase | None | glycine methyltransferase; S-adenosyl-L-methionine:glycine methyltransferase; GNMT | |
| 2.1.1.21 | methylamine---glutamate N-methyltransferase | False | 0 | 51 | 0 | 2 | methylamine + L-glutamate = NH3 + N-methyl-L-glutamate | methylamine:L-glutamate N-methyltransferase | None | N-methylglutamate synthase; methylamine-glutamate methyltransferase | |
| 2.1.1.22 | carnosine N-methyltransferase | False | 9 | 3833 | 4 | 7 | S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine | S-adenosyl-L-methionine:carnosine N-methyltransferase | None | None | |
| 2.1.1.25 | phenol O-methyltransferase | True | 0 | 0 | 0 | 6 | S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole | S-adenosyl-L-methionine:phenol O-methyltransferase | None | PMT | |
| 2.1.1.26 | iodophenol O-methyltransferase | True | 0 | 0 | 0 | 3 | S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether | S-adenosyl-L-methionine:2-iodophenol O-methyltransferase | None | None | |
| 2.1.1.27 | tyramine N-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + tyramine = S-adenosyl-L-homocysteine + N-methyltyramine | S-adenosyl-L-methionine:tyramine N-methyltransferase | None | DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid); S-adenosyl-methionine:tyramine N-methyltransferase; tyramine methylpherase | |
| 2.1.1.28 | phenylethanolamine N-methyltransferase | False | 6 | 181 | 44 | 11 | S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine | S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase | None | noradrenaline N-methyltransferase; noradrenalin N-methyltransferase; norepinephrine methyltransferase; norepinephrine N-methyltransferase; phenethanolamine methyltransferase; phenethanolamine N-methyltransferase | |
| 2.1.1.33 | tRNA (guanine46-N7)-methyltransferase | False | 557 | 37014 | 23 | 10 | S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA | S-adenosyl-L-methionine:tRNA (guanine-N7)-methyltransferase | None | Trm8/Trm82; TrmB; tRNA (m7G46) methyltransferase; transfer ribonucleate guanine 7-methyltransferase; 7-methylguanine transfer ribonucleate methylase; tRNA guanine 7-methyltransferase; N7-methylguanine methylase; S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase | |
| 2.1.1.34 | tRNA (guanosine18-2'-O)-methyltransferase | False | 8 | 6488 | 3 | 8 | S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA | S-adenosyl-L-methionine:tRNA (guanosine18-2'-O)-methyltransferase | None | tRNA (Gm18) 2'-O-methyltransferase; tRNA (Gm18) methyltransferase; TrmH; SpoU | |
| 2.1.1.208 | 23S rRNA (uridine2479-2'-O)-methyltransferase | False | 1 | 465 | 0 | 1 | S-adenosyl-L-methionine + uridine2479 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase | None | AviRb | |
| 2.1.1.35 | tRNA (uracil54-C5)-methyltransferase | False | 195 | 7834 | 1 | 8 | S-adenosyl-L-methionine + uracil54 in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil54 in tRNA | S-adenosyl-L-methionine:tRNA (uracil54-C5)-methyltransferase | None | transfer RNA uracil54 5-methyltransferase; transfer RNA uracil54 methylase; tRNA uracil54 5-methyltransferase; m5U54-methyltransferase; tRNA:m5U54-methyltransferase; RUMT; TrmA; 5-methyluridine54 tRNA methyltransferase; tRNA(uracil-54,C5)-methyltransferase; Trm2; tRNA(m5U54)methyltransferase | |
| 2.1.1.37 | DNA (cytosine-5-)-methyltransferase | False | 104 | 54259 | 126 | 43 | S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase | None | EcoRI methylase; DNA 5-cytosine methylase; DNA cytosine C5 methylase; DNA cytosine methylase; DNA methylase (ambiguous); DNA methyltransferase (ambiguous); DNA transmethylase (ambiguous); DNA-cytosine 5-methylase; DNA-cytosine methyltransferase; HpaII methylase; HpaII' methylase; M.BsuRIa; M.BsuRIb; Type II DNA methylase; cytosine 5-methyltransferase; cytosine DNA methylase; cytosine DNA methyltransferase; cytosine-specific DNA methyltransferase; deoxyribonucleate methylase (ambiguous); deoxyribonucleate methyltransferase (ambiguous); deoxyribonucleic (cytosine-5-)-methyltransferase; deoxyribonucleic acid (cytosine-5-)-methyltransferase; deoxyribonucleic acid methylase (ambiguous); deoxyribonucleic acid methyltransferase (ambiguous); deoxyribonucleic acid modification methylase (ambiguous); deoxyribonucleic methylase (ambiguous); methylphosphotriester-DNA methyltransferase (ambiguous); modification methylase (ambiguous); restriction-modification system (ambiguous); site-specific DNA-methyltransferase (cytosine-specific); DNA-(cytosine C5)-methylase | |
| 2.1.1.38 | O-demethylpuromycin O-methyltransferase | False | 1 | 84 | 0 | 1 | S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin | S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase | None | O-demethylpuromycin methyltransferase | |
| 2.1.1.39 | inositol 3-methyltransferase | True | 0 | 0 | 0 | 3 | S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol | S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase | None | inositol L-1-methyltransferase; myo-inositol 1-methyltransferase; S-adenosylmethionine:myo-inositol 1-methyltransferase; myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering); S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase | |
| 2.1.1.40 | inositol 1-methyltransferase | True | 0 | 0 | 0 | 2 | S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol | S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase | None | inositol D-1-methyltransferase; S-adenosylmethionine:myo-inositol 3-methyltransferase; myo-inositol 3-O-methyltransferase; inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering); S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase | |
| 2.1.1.41 | sterol 24-C-methyltransferase | False | 14 | 194 | 0 | 14 | S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase | None | Delta24-methyltransferase; Delta24-sterol methyltransferase; zymosterol-24-methyltransferase; S-adenosyl-4-methionine:sterol Delta24-methyltransferase; SMT1; 24-sterol C-methyltransferase; S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase; phytosterol methyltransferase | |
| 2.1.1.42 | flavone 3'-O-methyltransferase | False | 5 | 8 | 0 | 8 | S-adenosyl-L-methionine + 3'-hydroxyflavone = S-adenosyl-L-homocysteine + 3'-methoxyflavone | S-adenosyl-L-methionine:3'-hydroxyflavone 3'-O-methyltransferase | None | o-dihydric phenol methyltransferase; luteolin methyltransferase; luteolin 3'-O-methyltransferase; o-diphenol m-O-methyltransferase; o-dihydric phenol meta-O-methyltransferase; S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase; quercetin 3'-O-methyltransferase | |
| 2.1.1.233 | [phosphatase 2A protein]-leucine-carboxy methyltransferase | False | 21 | 4157 | 0 | 7 | S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase | None | leucine carboxy methyltransferase-1; LCMT1 | |
| 2.1.1.44 | L-histidine Nalpha-methyltransferase | False | 5 | 6106 | 16 | 2 | 3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction);;(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine;;(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine;;(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine | S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming) | None | dimethylhistidine N-methyltransferase; dimethylhistidine methyltransferase; histidine-alpha-N-methyltransferase; S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase; S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase | |
| 2.1.1.45 | thymidylate synthase | False | 446 | 36598 | 243 | 157 | 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP | 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase | None | dTMP synthase; thymidylate synthetase; methylenetetrahydrofolate:dUMP C-methyltransferase; TMP synthetase | |
| 2.1.1.46 | isoflavone 4'-O-methyltransferase | False | 4 | 5 | 1 | 3 | S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone | S-adenosyl-L-methionine:4'-hydroxyisoflavone 4'-O-methyltransferase | None | 4'-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase | |
| 2.1.1.47 | indolepyruvate C-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (R)-3-(indol-3-yl)-2-oxobutanoate | S-adenosyl-L-methionine:(indol-3-yl)pyruvate C3-methyltransferase | None | ind1 (gene name); indolepyruvate methyltransferase; indolepyruvate 3-methyltransferase; indolepyruvic acid methyltransferase; S-adenosyl-L-methionine:indolepyruvate C-methyltransferase | |
| 2.1.1.49 | amine N-methyltransferase | False | 4 | 21 | 1 | 3 | S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine | S-adenosyl-L-methionine:amine N-methyltransferase | None | nicotine N-methyltransferase; tryptamine N-methyltransferase; arylamine N-methyltransferase; tryptamine methyltransferase | |
| 2.1.1.50 | loganate O-methyltransferase | False | 1 | 54 | 0 | 1 | S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin | S-adenosyl-L-methionine:loganate 11-O-methyltransferase | None | loganate methyltransferase; S-adenosyl-L-methionine:loganic acid methyltransferase | |
| 2.1.1.53 | putrescine N-methyltransferase | False | 7 | 31 | 0 | 21 | S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine | S-adenosyl-L-methionine:putrescine N-methyltransferase | None | putrescine methyltransferase | |
| 2.1.1.54 | deoxycytidylate C-methyltransferase | True | 0 | 0 | 0 | 1 | 5,10-methylenetetrahydrofolate + dCMP = dihydrofolate + deoxy-5-methylcytidylate | 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase | None | deoxycytidylate methyltransferase; dCMP methyltransferase | |
| 2.1.1.55 | tRNA (adenine-N6-)-methyltransferase | False | 0 | 7 | 0 | 2 | S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine | S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase | None | S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase | |
| 2.1.1.56 | mRNA (guanine-N7)-methyltransferase | False | 183 | 7862 | 44 | 20 | S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] | S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase | None | RNMT (gene name); ABD1 (gene name); messenger ribonucleate guanine 7-methyltransferase; guanine-7-methyltransferase; messenger RNA guanine 7-methyltransferase; S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase | |
| 2.1.1.57 | methyltransferase cap1 | False | 118 | 3054 | 55 | 12 | S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA] | S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase | None | FTSJD2 (gene name); messenger ribonucleate nucleoside 2'-methyltransferase; messenger RNA (nucleoside-2'-)-methyltransferase; MTR1; cap1-MTase; mRNA (nucleoside-2'-O)-methyltransferase (ambiguous); S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase | |
| 2.1.1.59 | [cytochrome c]-lysine N-methyltransferase | False | 4 | 15 | 0 | 4 | S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine | S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase | None | cytochrome c (lysine) methyltransferase; cytochrome c methyltransferase; cytochrome c-specific protein methylase III; cytochrome c-specific protein-lysine methyltransferase; S-adenosyl-L-methionine:[cytochrome c]-L-lysine 6-N-methyltransferase | |
| 2.1.1.60 | calmodulin-lysine N-methyltransferase | False | 5 | 1744 | 1 | 7 | S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine | S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase | None | S-adenosylmethionine:calmodulin (lysine) N-methyltransferase; S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase | |
| 2.1.1.61 | tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase | False | 183 | 7444 | 4 | 3 | S-adenosyl-L-methionine + tRNA containing 5-(aminomethyl)-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-[(methylamino)methyl]-2-thiouridylate | S-adenosyl-L-methionine:tRNA 5-(aminomethyl)-2-thiouridylate N-methyltransferase | None | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase; tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase; S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | |
| 2.1.1.62 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase | False | 3 | 101 | 13 | 4 | S-adenosyl-L-methionine + a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA] | S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase | None | messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase; S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase | |
| 2.1.1.63 | methylated-DNA---[protein]-cysteine S-methyltransferase | False | 56 | 37956 | 38 | 21 | (1) DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine;;(2) DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine | DNA-6-O-methylguanine/DNA-4-O-methylthymine:[protein]-L-cysteine S-methyltransferase | None | ada (gene name); ogt (gene name); MGT1 (gene name); MGMT (gene name) | |
| 2.1.1.64 | 3-demethylubiquinol 3-O-methyltransferase | False | 253 | 16874 | 2 | 5 | S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n | S-adenosyl-L-methionine:3-hydroxy-2-methoxy-5-methyl-6-(all-trans-polyprenyl)-1,4-benzoquinol 3-O-methyltransferase | None | 5-demethylubiquinone-9 methyltransferase; OMHMB-methyltransferase; 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase; S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase; COQ3 (gene name); Coq3 O-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; ubiG (gene name, ambiguous) | |
| 2.1.1.65 | licodione 2'-O-methyltransferase | False | 1 | 1 | 0 | 2 | S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O-methyllicodione | S-adenosyl-L-methionine:licodione 2'-O-methyltransferase | None | None | |
| 2.1.1.67 | thiopurine S-methyltransferase | False | 94 | 5246 | 6 | 5 | S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether | S-adenosyl-L-methionine:thiopurine S-methyltransferase | None | mercaptopurine methyltransferase; thiopurine methyltransferase; 6-thiopurine transmethylase; TPMT | |
| 2.1.1.68 | caffeate O-methyltransferase | False | 22 | 398 | 4 | 31 | S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate | S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase | None | caffeate methyltransferase; caffeate 3-O-methyltransferase; S-adenosyl-L-methionine:caffeic acid-O-methyltransferase | |
| 2.1.1.69 | 5-hydroxyfuranocoumarin 5-O-methyltransferase | False | 4 | 1 | 1 | 6 | (1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction);; (2) S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten | S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase | None | furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferase; BMT; S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase | |
| 2.1.1.70 | 8-hydroxyfuranocoumarin 8-O-methyltransferase | False | 1 | 0 | 0 | 3 | (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction);; (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin | S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase | None | furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyl-transferase; xanthotoxol 8-O-methyltransferase; XMT; 8-hydroxyfuranocoumarin 8-O-methyltransferase; SAM:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase; xanthotoxol methyltransferase; xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine-xanthotoxol O-methyltransferase | |
| 2.1.1.71 | phosphatidyl-N-methylethanolamine N-methyltransferase | False | 11 | 3465 | 0 | 10 | S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine | S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase | None | phosphatidylmonomethylethanolamine methyltransferase; methyltransferase II; phospholipid methyltransferase; PLMT; phosphatidyl-N-methylethanolamine methyltransferase; phosphatidyl-N-monomethylethanolamine methyltransferase; phosphatidylethanolamine methyltransferase I; phosphatidylmonomethylethanolamine methyltransferase | |
| 2.1.1.72 | site-specific DNA-methyltransferase (adenine-specific) | False | 107 | 126558 | 71 | 86 | S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA | S-adenosyl-L-methionine:adenine in DNA N6-methyltransferase | None | modification methylase; restriction-modification system | |
| 2.1.1.74 | methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing] | False | 256 | 11606 | 3 | 13 | 5,10-methylenetetrahydrofolate + uracil54 in tRNA + NAD(P)H + H+ = tetrahydrofolate + 5-methyluracil54 in tRNA + NAD(P)+ | 5,10-methylenetetrahydrofolate:tRNA (uracil54-C5)-methyltransferase | None | folate-dependent ribothymidyl synthase; methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase; 5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase; 5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyl-transferase; TrmFO; folate/FAD-dependent tRNA T54 methyltransferase; methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing) | |
| 2.1.1.75 | apigenin 4'-O-methyltransferase | False | 1 | 0 | 0 | 3 | S-adenosyl-L-methionine + apigenin = S-adenosyl-L-homocysteine + acacetin | S-adenosyl-L-methionine:apigenin 4'-O-methyltransferase | None | flavonoid O-methyltransferase; flavonoid methyltransferase; S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase | |
| 2.1.1.76 | quercetin 3-O-methyltransferase | False | 2 | 49 | 0 | 8 | S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone | S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase | None | flavonol 3-O-methyltransferase; flavonoid 3-methyltransferase | |
| 2.1.1.77 | protein-L-isoaspartate(D-aspartate) O-methyltransferase | False | 332 | 41564 | 14 | 34 | S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase | None | protein-L-isoaspartate O-methyltransferase; protein-beta-aspartate O-methyltransferase; D-aspartyl/L-isoaspartyl methyltransferase; L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase; protein (D-aspartate) methyltransferase; protein D-aspartate methyltransferase; protein L-isoaspartate methyltransferase; protein L-isoaspartyl methyltransferase; protein O-methyltransferase (L-isoaspartate); L-aspartyl/L-isoaspartyl protein methyltransferase | |
| 2.1.1.78 | isoorientin 3'-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + isoorientin = S-adenosyl-L-homocysteine + isoscoparin | S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase | None | isoorientin 3'-methyltransferase | |
| 2.1.1.79 | cyclopropane-fatty-acyl-phospholipid synthase | False | 15 | 6218 | 9 | 19 | S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid | S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) | None | cyclopropane synthetase; unsaturated-phospholipid methyltransferase; cyclopropane synthase; cyclopropane fatty acid synthase; cyclopropane fatty acid synthetase; CFA synthase | |
| 2.1.1.80 | protein-glutamate O-methyltransferase | False | 22 | 29008 | 7 | 15 | S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester | S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase | None | methyl-accepting chemotaxis protein O-methyltransferase; S-adenosylmethionine-glutamyl methyltransferase; methyl-accepting chemotaxis protein methyltransferase II; S-adenosylmethionine:protein-carboxyl O-methyltransferase; protein methylase II; MCP methyltransferase I; MCP methyltransferase II; protein O-methyltransferase; protein(aspartate)methyltransferase; protein(carboxyl)methyltransferase; protein carboxyl-methylase; protein carboxyl-O-methyltransferase; protein carboxylmethyltransferase II; protein carboxymethylase; protein carboxymethyltransferase; protein methyltransferase II | |
| 2.1.1.82 | 3-methylquercetin 7-O-methyltransferase | False | 2 | 0 | 0 | 3 | S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone | S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase | None | flavonol 7-O-methyltransferase; flavonol 7-methyltransferase; 7-OMT; S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase; 3-methylquercitin 7-O-methyltransferase [mis-spelt] | |
| 2.1.1.83 | 3,7-dimethylquercetin 4'-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 5,3'-dihydroxy-3,7,4'-trimethoxyflavone | S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase | None | flavonol 4'-O-methyltransferase; flavonol 4'-methyltransferase; 4'-OMT; S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase; 3,7-dimethylquercitin 4'-O-methyltransferase [mis-spelt] | |
| 2.1.1.84 | methylquercetagetin 6-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone | S-adenosyl-L-methionine:5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase | None | flavonol 6-O-methyltransferase; flavonol 6-methyltransferase; 6-OMT; S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase | |
| 2.1.1.85 | protein-histidine N-methyltransferase | False | 22 | 5616 | 10 | 4 | S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine | S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase | None | protein methylase IV; protein (histidine) methyltransferase; actin-specific histidine methyltransferase; S-adenosyl methionine:protein-histidine N-methyltransferase | |
| 2.1.1.87 | pyridine N-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium | S-adenosyl-L-methionine:pyridine N-methyltransferase | None | pyridine methyltransferase | |
| 2.1.1.88 | 8-hydroxyquercetin 8-O-methyltransferase | False | 1 | 1 | 0 | 3 | S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone | S-adenosyl-L-methionine:3,5,7,8,3',4'-hexahydroxyflavone 8-O-methyltransferase | None | flavonol 8-O-methyltransferase; flavonol 8-methyltransferase; S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase; 8-hydroxyquercitin 8-O-methyltransferase [mis-spelt] | |
| 2.1.1.89 | tetrahydrocolumbamine 2-O-methyltransferase | False | 2 | 0 | 0 | 2 | S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine | S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase | None | tetrahydrocolumbamine methyltransferase | |
| 2.1.1.90 | methanol---corrinoid protein Co-methyltransferase | False | 1 | 25 | 1 | 8 | methanol + a [Co(I) methanol-specific corrinoid protein] = a [methyl-Co(III) methanol-specific corrinoid protein] + H2O | methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase | None | methanol cobalamin methyltransferase; methanol:5-hydroxybenzimidazolylcobamide methyltransferase; MT 1 (ambiguous); methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase; mtaB (gene name) | |
| 2.1.1.91 | isobutyraldoxime O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 2-methylpropanal oxime = S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime | S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase | None | aldoxime methyltransferase; S-adenosylmethionine:aldoxime O-methyltransferase; aldoxime O-methyltransferase | |
| 2.1.1.94 | tabersonine 16-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + 16-hydroxytabersonine = S-adenosyl-L-homocysteine + 16-methoxytabersonine | S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase | None | 11-demethyl-17-deacetylvindoline 11-methyltransferase; 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase; S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase | |
| 2.1.1.95 | tocopherol C-methyltransferase | False | 2 | 134 | 0 | 18 | (1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol ;;(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol ;;(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol ;;(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol | S-adenosyl-L-methionine:gamma-tocopherol 5-C-methyltransferase | None | gamma-tocopherol methyltransferase; VTE4 (gene name); S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase (incorrect); tocopherol O-methyltransferase (incorrect) | |
| 2.1.1.96 | thioether S-methyltransferase | False | 4 | 0 | 0 | 1 | S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium | S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase | None | S-adenosyl-L-methionine:thioether S-methyltransferase; thioether methyltransferase | |
| 2.1.1.97 | 3-hydroxyanthranilate 4-C-methyltransferase | True | 0 | 0 | 0 | 3 | S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate | S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase | None | 3-hydroxyanthranilate 4-methyltransferase | |
| 2.1.1.98 | diphthine synthase | False | 51 | 2530 | 84 | 3 | 3 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2] (overall reaction);;(1a) S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2];;(1b) S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2];;(1c) S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2] | S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine-[translation elongation factor 2]-forming) | None | S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase; Dph5 (ambiguous) | |
| 2.1.1.99 | 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline | S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase | None | 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase; NMT; 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase; S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase | |
| 2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase | False | 13 | 6723 | 2 | 14 | S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase | None | farnesyl cysteine C-terminal methyltransferase; farnesyl-protein carboxymethyltransferase; protein C-terminal farnesylcysteine O-methyltransferase; farnesylated protein C-terminal O-methyltransferase; isoprenylated protein methyltransferase; prenylated protein methyltransferase; protein S-farnesylcysteine C-terminal methyltransferase; S-farnesylcysteine methyltransferase; prenylcysteine carboxylmethyltransferase [misleading]; prenylcysteine carboxymethyltransferase [misleading]; prenylcysteine methyltransferase | |
| 2.1.1.101 | macrocin O-methyltransferase | False | 1 | 73 | 0 | 1 | S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin | S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase | None | macrocin methyltransferase; S-adenosyl-L-methionine-macrocin O-methyltransferase; MOMT (ambiguous); tylF (gene name) | |
| 2.1.1.102 | demethylmacrocin O-methyltransferase | False | 1 | 31 | 0 | 1 | S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin | S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase | None | demethylmacrocin methyltransferase; DMOMT | |
| 2.1.1.103 | phosphoethanolamine N-methyltransferase | False | 10 | 2656 | 4 | 25 | S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase | None | phosphoethanolamine methyltransferase | |
| 2.1.1.104 | caffeoyl-CoA O-methyltransferase | False | 34 | 1420 | 5 | 36 | S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA | S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase | None | caffeoyl coenzyme A methyltransferase; caffeoyl-CoA 3-O-methyltransferase; trans-caffeoyl-CoA 3-O-methyltransferase | |
| 2.1.1.105 | N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + N-benzoyl-4-hydroxyanthranilate = S-adenosyl-L-homocysteine + N-benzoyl-4-methoxyanthranilate | S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase | None | N-benzoyl-4-hydroxyanthranilate 4-methyltransferase; benzoyl-CoA:anthranilate N-benzoyltransferase | |
| 2.1.1.106 | tryptophan 2-C-methyltransferase | False | 1 | 30 | 0 | 1 | S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan | S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase | None | tsrM (gene name); tryptophan 2-methyltransferase; S-adenosylmethionine:tryptophan 2-methyltransferase | |
| 2.1.1.107 | uroporphyrinogen-III C-methyltransferase | False | 158 | 40764 | 21 | 15 | 2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction);; (1a) S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1;;(1b) S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2 | S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase | None | uroporphyrinogen methyltransferase; uroporphyrinogen-III methyltransferase; adenosylmethionine-uroporphyrinogen III methyltransferase; S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase; uroporphyrinogen-III methylase; SirA; CysG; CobA [ambiguous - see EC 2.5.1.17] SUMT; uroporphyrin-III C-methyltransferase (incorrect); S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase (incorrect) | |
| 2.1.1.108 | 6-hydroxymellein O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein | S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase | None | 6-hydroxymellein methyltransferase | |
| 2.1.1.109 | demethylsterigmatocystin 6-O-methyltransferase | False | 3 | 8 | 0 | 2 | S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin | S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase | None | demethylsterigmatocystin methyltransferase; O-methyltransferase I | |
| 2.1.1.110 | sterigmatocystin 8-O-methyltransferase | False | 2 | 13 | 0 | 2 | (1) S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin;;(2) S-adenosyl-L-methionine + dihydrosterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin | S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase | None | sterigmatocystin methyltransferase; O-methyltransferase II; sterigmatocystin 7-O-methyltransferase (incorrect); S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase (incorrect); OmtA | |
| 2.1.1.111 | anthranilate N-methyltransferase | False | 1 | 6 | 0 | 2 | S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate | S-adenosyl-L-methionine:anthranilate N-methyltransferase | None | anthranilic acid N-methyltransferase | |
| 2.1.1.112 | glucuronoxylan 4-O-methyltransferase | False | 3 | 53 | 0 | 1 | S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate | S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase | None | None | |
| 2.1.1.113 | site-specific DNA-methyltransferase (cytosine-N4-specific) | False | 22 | 9910 | 1 | 39 | S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine | S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase | None | modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase | |
| 2.1.1.114 | polyprenyldihydroxybenzoate methyltransferase | False | 9 | 2872 | 0 | 6 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate | S-adenosyl-L-methionine:3,4-dihydroxy-5-all-trans-polyprenylbenzoate 3-O-methyltransferase | None | 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; COQ3 (gene name); Coq3 O-methyltransferase; DHHB O-methyltransferase | |
| 2.1.1.115 | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase | False | 0 | 1 | 3 | 32 | S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase | None | norreticuline N-methyltransferase | |
| 2.1.1.116 | 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase | False | 3 | 6 | 0 | 5 | S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline | S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase | None | None | |
| 2.1.1.117 | (S)-scoulerine 9-O-methyltransferase | False | 6 | 9 | 4 | 9 | S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine | S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase | None | None | |
| 2.1.1.118 | columbamine O-methyltransferase | False | 1 | 0 | 0 | 3 | S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine | S-adenosyl-L-methionine:columbamine O-methyltransferase | None | None | |
| 2.1.1.119 | 10-hydroxydihydrosanguinarine 10-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine | S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase | None | None | |
| 2.1.1.120 | 12-hydroxydihydrochelirubine 12-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine | S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase | None | None | |
| 2.1.1.121 | 6-O-methylnorlaudanosoline 5'-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline | S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase | None | None | |
| 2.1.1.122 | (S)-tetrahydroprotoberberine N-methyltransferase | False | 3 | 1 | 3 | 11 | S-adenosyl-L-methionine + an (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine | S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase | None | tetrahydroprotoberberine cis-N-methyltransferase | |
| 2.1.1.123 | [cytochrome-c]-methionine S-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine | S-adenosyl-L-methionine:[cytochrome c]-methionine S-methyltransferase | None | None | |
| 2.1.1.127 | [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase | False | 2 | 56 | 7 | 5 | 3 S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-L-lysine = 3 S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6,N6,N6-trimethyl-L-lysine | S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine N6-methyltransferase | None | rubisco methyltransferase; ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase; ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase; S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine 6-N-methyltransferase; RuBisCO methyltransferase; RuBisCO LSMT | |
| 2.1.1.128 | (RS)-norcoclaurine 6-O-methyltransferase | False | 3 | 6 | 4 | 7 | S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine | S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase | None | None | |
| 2.1.1.129 | inositol 4-methyltransferase | False | 1 | 0 | 0 | 4 | S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-4-O-methyl-myo-inositol | S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase | None | myo-inositol 4-O-methyltransferase; S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase; myo-inositol 6-O-methyltransferase | |
| 2.1.1.130 | precorrin-2 C20-methyltransferase | False | 5 | 6751 | 2 | 3 | S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A | S-adenosyl-L-methionine:precorrin-2 C20-methyltransferase | None | None | |
| 2.1.1.131 | precorrin-3B C17-methyltransferase | False | 4 | 6058 | 0 | 3 | S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 | S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase | None | precorrin-3 methyltransferase; CobJ | |
| 2.1.1.132 | precorrin-6B C5,15-methyltransferase (decarboxylating) | False | 4 | 1809 | 2 | 4 | 2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2 (overall reaction);;(1a) S-adenosyl-L-methionine + precorrin-6B = S-adenosyl-L-homocysteine + precorrin-7 + CO2;;(1b) S-adenosyl-L-methionine + precorrin-7 = S-adenosyl-L-homocysteine + precorrin-8X | S-adenosyl-L-methionine:1-precorrin-6B C5,15-methyltransferase (C-12-decarboxylating) | None | precorrin-6 methyltransferase; precorrin-6Y methylase; precorrin-6Y C5,15-methyltransferase (decarboxylating); cobL (gene name) | |
| 2.1.1.133 | precorrin-4 C11-methyltransferase | False | 6 | 6406 | 4 | 1 | S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 | S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase | None | precorrin-3 methylase; CobM | |
| 2.1.1.136 | chlorophenol O-methyltransferase | False | 1 | 0 | 0 | 2 | S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole | S-adenosyl-L-methionine:trichlorophenol O-methyltransferase | None | halogenated phenol O-methyltransferase; trichlorophenol O-methyltransferase | |
| 2.1.1.137 | arsenite methyltransferase | False | 8 | 253 | 1 | 24 | (1) S-adenosyl-L-methionine + arsenic triglutathione + thioredoxin + 2 H2O = S-adenosyl-L-homocysteine + methylarsonous acid + 3 glutathione + thioredoxin disulfide;;(2) 2 S-adenosyl-L-methionine + arsenic triglutathione + 2 thioredoxin + H2O = S-adenosyl-L-homocysteine + dimethylarsinous acid + 3 glutathione + 2 thioredoxin disulfide;;(3) 3 S-adenosyl-L-methionine + arsenic triglutathione + 3 thioredoxin = S-adenosyl-L-homocysteine + trimethylarsane + 3 glutathione + 3 thioredoxin disulfide | S-adenosyl-L-methionine:arsenous acid As-methyltransferase | None | AS3MT (gene name); arsM (gene name); S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosyl-L-methionine:methylarsonite As-methyltransferase; methylarsonite methyltransferase | |
| 2.1.1.139 | 3'-demethylstaurosporine O-methyltransferase | False | 0 | 1 | 0 | 2 | S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine | S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase | None | 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase; staurosporine synthase | |
| 2.1.1.140 | (S)-coclaurine-N-methyltransferase | False | 2 | 15 | 0 | 21 | S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine | S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase | None | None | |
| 2.1.1.141 | jasmonate O-methyltransferase | False | 4 | 95 | 0 | 12 | S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyl jasmonate | S-adenosyl-L-methionine:jasmonate O-methyltransferase | None | jasmonic acid carboxyl methyltransferase | |
| 2.1.1.142 | cycloartenol 24-C-methyltransferase | True | 0 | 0 | 0 | 14 | S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + cyclolaudenol | S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase | None | sterol C-methyltransferase | |
| 2.1.1.143 | 24-methylenesterol C-methyltransferase | False | 3 | 7 | 0 | 8 | S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol | S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase | None | SMT2; 24-methylenelophenol C-241-methyltransferase | |
| 2.1.1.144 | trans-aconitate 2-methyltransferase | False | 90 | 6116 | 2 | 2 | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase | None | None | |
| 2.1.1.145 | trans-aconitate 3-methyltransferase | False | 2 | 50 | 1 | 2 | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase | None | None | |
| 2.1.1.146 | (iso)eugenol O-methyltransferase | False | 4 | 50 | 5 | 5 | S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol | S-adenosyl-L-methionine:isoeugenol O-methyltransferase | None | None | |
| 2.1.1.147 | corydaline synthase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+ | S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase | None | None | |
| 2.1.1.148 | thymidylate synthase (FAD) | False | 78 | 12617 | 36 | 40 | 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+ | 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase | None | Thy1; ThyX | |
| 2.1.1.150 | isoflavone 7-O-methyltransferase | False | 4 | 13 | 1 | 2 | S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone | S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase | None | None | |
| 2.1.1.151 | cobalt-factor II C20-methyltransferase | False | 2 | 2252 | 0 | 3 | S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III | S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase | None | CbiL | |
| 2.1.1.152 | precorrin-6A synthase (deacetylating) | False | 1 | 2900 | 0 | 1 | S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate | S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating) | None | precorrin-6X synthase (deacetylating); CobF | |
| 2.1.1.153 | vitexin 2''-O-rhamnoside 7-O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside | S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase | None | None | |
| 2.1.1.154 | isoliquiritigenin 2'-O-methyltransferase | False | 2 | 1 | 0 | 1 | S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin | S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase | None | chalcone OMT; CHMT | |
| 2.1.1.155 | kaempferol 4'-O-methyltransferase | False | 3 | 0 | 0 | 2 | S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide | S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase | None | S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase; F 4'-OMT | |
| 2.1.1.156 | glycine/sarcosine N-methyltransferase | False | 4 | 634 | 5 | 6 | 2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction);;(1a) S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine;;(1b) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine | S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase [sarcosine(or N,N-dimethylglycine)-forming] | None | ApGSMT; glycine-sarcosine methyltransferase; GSMT; GMT; glycine sarcosine N-methyltransferase; S-adenosyl-L-methionine:sarcosine N-methyltransferase | |
| 2.1.1.157 | sarcosine/dimethylglycine N-methyltransferase | False | 3 | 221 | 0 | 6 | 2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine (overall reaction);;(1a) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine;;(1b) S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine | S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming] | None | ApDMT; sarcosine-dimethylglycine methyltransferase; SDMT; sarcosine dimethylglycine N-methyltransferase; S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase | |
| 2.1.2.1 | glycine hydroxymethyltransferase | False | 797 | 57747 | 152 | 75 | 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase | None | serine aldolase; threonine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; allothreonine aldolase; L-serine hydroxymethyltransferase; L-threonine aldolase; serine transhydroxymethylase | |
| 2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 | False | 26 | 45645 | 39 | 21 | 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide | 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase | None | 2-amino-N-ribosylacetamide 5'-phosphate transformylase; GAR formyltransferase; GAR transformylase; glycinamide ribonucleotide transformylase; GAR TFase; 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase; purN (gene name); ADE8 (gene name); GART (gene name); 5'-phosphoribosylglycinamide transformylase; phosphoribosylglycinamide formyltransferase (ambiguous) | |
| 2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase | False | 472 | 40022 | 15 | 21 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase | None | 5-amino-4-imidazolecarboxamide ribonucleotide transformylase; AICAR transformylase; 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase; 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase; 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase; 5-amino-4-imidazolecarboxamide ribotide transformylase; AICAR formyltransferase; aminoimidazolecarboxamide ribonucleotide transformylase | |
| 2.1.2.4 | glycine formimidoyltransferase | True | 0 | 0 | 0 | 2 | 5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine | 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase | None | formiminoglycine formiminotransferase; FIG formiminotransferase; glycine formiminotransferase | |
| 2.1.2.5 | glutamate formimidoyltransferase | False | 10 | 8520 | 3 | 14 | 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate | 5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase | None | FTCD (gene name); glutamate formyltransferase; formiminoglutamic acid transferase; formiminoglutamic formiminotransferase; glutamate formiminotransferase | |
| 2.1.2.7 | D-alanine 2-hydroxymethyltransferase | False | 3 | 203 | 0 | 5 | 5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine | 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase | None | 2-methylserine hydroxymethyltransferase | |
| 2.1.2.8 | deoxycytidylate 5-hydroxymethyltransferase | False | 3 | 76 | 6 | 5 | 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate | 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase | None | dCMP hydroxymethylase; d-cytidine 5'-monophosphate hydroxymethylase; deoxyCMP hydroxymethylase; deoxycytidylate hydroxymethylase; deoxycytidylic hydroxymethylase | |
| 2.1.2.9 | methionyl-tRNA formyltransferase | False | 690 | 47002 | 10 | 15 | 10-formyltetrahydrofolate + L-methionyl-tRNAfMet = tetrahydrofolate + N-formylmethionyl-tRNAfMet | 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase | None | N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase; formylmethionyl-transfer ribonucleic synthetase; methionyl ribonucleic formyltransferase; methionyl-tRNA Met formyltransferase; methionyl-tRNA transformylase; methionyl-transfer RNA transformylase; methionyl-transfer ribonucleate methyltransferase; methionyl-transfer ribonucleic transformylase | |
| 2.1.2.10 | aminomethyltransferase | False | 334 | 38070 | 16 | 11 | [protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3 | [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) | None | S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming); T-protein; glycine synthase; tetrahydrofolate aminomethyltransferase; [protein]-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) | |
| 2.1.2.11 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | False | 575 | 39884 | 6 | 7 | 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate | 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase | None | alpha-ketoisovalerate hydroxymethyltransferase; dehydropantoate hydroxymethyltransferase; ketopantoate hydroxymethyltransferase; oxopantoate hydroxymethyltransferase; 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase | |
| 2.1.3.1 | methylmalonyl-CoA carboxytransferase | False | 3 | 1987 | 12 | 8 | (S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate | (S)-methylmalonyl-CoA:pyruvate carboxytransferase | None | transcarboxylase; methylmalonyl coenzyme A carboxyltransferase; methylmalonyl-CoA transcarboxylase; oxalacetic transcarboxylase; methylmalonyl-CoA carboxyltransferase; (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase; (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase carboxytransferase [incorrect] | |
| 2.1.3.2 | aspartate carbamoyltransferase | False | 716 | 42016 | 102 | 50 | carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | carbamoyl-phosphate:L-aspartate carbamoyltransferase | None | carbamylaspartotranskinase; aspartate transcarbamylase; aspartate carbamyltransferase; aspartic acid transcarbamoylase; aspartic carbamyltransferase; aspartic transcarbamylase; carbamylaspartotranskinase; L-aspartate transcarbamoylase; L-aspartate transcarbamylase; carbamoylaspartotranskinase; aspartate transcarbamylase; aspartate transcarbamoylase; ATCase | |
| 2.1.3.3 | ornithine carbamoyltransferase | False | 406 | 41057 | 46 | 72 | carbamoyl phosphate + L-ornithine = phosphate + L-citrulline | carbamoyl-phosphate:L-ornithine carbamoyltransferase | None | citrulline phosphorylase; ornithine transcarbamylase; OTC; carbamylphosphate-ornithine transcarbamylase; L-ornithine carbamoyltransferase; L-ornithine carbamyltransferase; L-ornithine transcarbamylase; ornithine carbamyltransferase | |
| 2.1.3.5 | oxamate carbamoyltransferase | False | 0 | 1 | 0 | 2 | carbamoyl phosphate + oxamate = phosphate + N-carbamoyl-2-oxoglycine | carbamoyl-phosphate:oxamate carbamoyltransferase | None | oxamic transcarbamylase | |
| 2.1.3.6 | putrescine carbamoyltransferase | False | 13 | 355 | 5 | 5 | carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine | carbamoyl-phosphate:putrescine carbamoyltransferase | None | PTCase; putrescine synthase; putrescine transcarbamylase | |
| 2.1.3.7 | 3-hydroxymethylcephem carbamoyltransferase | False | 0 | 22 | 0 | 3 | carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem | carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase | None | None | |
| 2.1.3.8 | lysine carbamoyltransferase | True | 0 | 0 | 0 | 3 | carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline | carbamoyl-phosphate:L-lysine carbamoyltransferase | None | lysine transcarbamylase | |
| 2.1.3.9 | N-acetylornithine carbamoyltransferase | False | 4 | 1137 | 14 | 2 | carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline | carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase | None | acetylornithine transcarbamylase; N-acetylornithine transcarbamylase; AOTC; carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase; AOTCase | |
| 2.1.4.1 | glycine amidinotransferase | False | 11 | 1442 | 11 | 17 | L-arginine + glycine = L-ornithine + guanidinoacetate | L-arginine:glycine amidinotransferase | None | arginine-glycine amidinotransferase; arginine-glycine transamidinase; glycine transamidinase | |
| 2.1.4.2 | scyllo-inosamine-4-phosphate amidinotransferase | False | 4 | 108 | 1 | 11 | L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate | L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase | None | L-arginine:inosamine-P-amidinotransferase; inosamine-P amidinotransferase; L-arginine:inosamine phosphate amidinotransferase; inosamine-phosphate amidinotransferase | |
| 2.2.1.1 | transketolase | False | 83 | 48288 | 78 | 33 | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase | None | glycolaldehydetransferase | |
| 2.2.1.2 | transaldolase | False | 472 | 41553 | 56 | 36 | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase | None | dihydroxyacetonetransferase; dihydroxyacetone synthase (incorrect); formaldehyde transketolase (incorrect) | |
| 2.2.1.3 | formaldehyde transketolase | False | 2 | 28 | 0 | 4 | D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + glycerone | D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase | None | dihydroxyacetone synthase | |
| 2.2.1.4 | acetoin---ribose-5-phosphate transaldolase | True | 0 | 0 | 0 | 1 | 3-hydroxybutan-2-one + D-ribose 5-phosphate = acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate | 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase | None | 1-deoxy-D-altro-heptulose-7-phosphate synthetase; 1-deoxy-D-altro-heptulose-7-phosphate synthase; 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase [wrong substrate name] | |
| 2.2.1.5 | 2-hydroxy-3-oxoadipate synthase | False | 13 | 472 | 15 | 10 | 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) | None | 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating); alpha-ketoglutaric-glyoxylic carboligase; oxoglutarate: glyoxylate carboligase | |
| 2.2.1.6 | acetolactate synthase | False | 80 | 91612 | 60 | 81 | 2 pyruvate = 2-acetolactate + CO2 | pyruvate:pyruvate acetaldehydetransferase (decarboxylating) | None | alpha-acetohydroxy acid synthetase; alpha-acetohydroxyacid synthase; alpha-acetolactate synthase; alpha-acetolactate synthetase; acetohydroxy acid synthetase; acetohydroxyacid synthase; acetolactate pyruvate-lyase (carboxylating); acetolactic synthetase | |
| 2.2.1.7 | 1-deoxy-D-xylulose-5-phosphate synthase | False | 522 | 42832 | 18 | 40 | pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2 | pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating) | None | 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating); DXP-synthase | |
| 2.2.1.8 | fluorothreonine transaldolase | False | 1 | 38 | 0 | 2 | L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine | fluoroacetaldehyde:L-threonine aldehydetransferase | None | None | |
| 2.3.1.1 | amino-acid N-acetyltransferase | False | 333 | 41583 | 18 | 34 | acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate | acetyl-CoA:L-glutamate N-acetyltransferase | None | N-acetylglutamate synthase; AGAS; acetylglutamate acetylglutamate synthetase; acetylglutamic synthetase; amino acid acetyltransferase; N-acetyl-L-glutamate synthetase; N-acetylglutamate synthetase | |
| 2.3.1.2 | imidazole N-acetyltransferase | False | 0 | 4 | 0 | 1 | acetyl-CoA + imidazole = CoA + N-acetylimidazole | acetyl-CoA:imidazole N-acetyltransferase | None | imidazole acetylase; imidazole acetyltransferase | |
| 2.3.1.3 | glucosamine N-acetyltransferase | False | 0 | 2 | 0 | 4 | acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine | acetyl-CoA:D-glucosamine N-acetyltransferase | None | glucosamine acetylase; glucosamine acetyltransferase | |
| 2.3.1.4 | glucosamine-phosphate N-acetyltransferase | False | 14 | 4042 | 16 | 30 | acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate | acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase | None | phosphoglucosamine transacetylase; phosphoglucosamine acetylase; glucosamine-6-phosphate acetylase; D-glucosamine-6-P N-acetyltransferase; aminodeoxyglucosephosphate acetyltransferase; glucosamine 6-phosphate acetylase; glucosamine 6-phosphate N-acetyltransferase; N-acetylglucosamine-6-phosphate synthase; phosphoglucosamine N-acetylase; glucosamine-6-phosphate N-acetyltransferase | |
| 2.3.1.5 | arylamine N-acetyltransferase | False | 26 | 2662 | 23 | 65 | acetyl-CoA + an arylamine = CoA + an N-acetylarylamine | acetyl-CoA:arylamine N-acetyltransferase | None | arylamine acetylase; beta-naphthylamine N-acetyltransferase; 4-aminobiphenyl N-acetyltransferase; acetyl CoA-arylamine N-acetyltransferase; 2-naphthylamine N-acetyltransferase; arylamine acetyltransferase; indoleamine N-acetyltransferase; N-acetyltransferase (ambiguous); p-aminosalicylate N-acetyltransferase; serotonin acetyltransferase; serotonin N-acetyltransferase | |
| 2.3.1.6 | choline O-acetyltransferase | False | 8 | 1888 | 7 | 65 | acetyl-CoA + choline = CoA + O-acetylcholine | acetyl-CoA:choline O-acetyltransferase | None | choline acetylase; choline acetyltransferase | |
| 2.3.1.7 | carnitine O-acetyltransferase | False | 8 | 249 | 7 | 20 | acetyl-CoA + carnitine = CoA + O-acetylcarnitine | acetyl-CoA:carnitine O-acetyltransferase | None | acetyl-CoA-carnitine O-acetyltransferase; acetylcarnitine transferase; carnitine acetyl coenzyme A transferase; carnitine acetylase; carnitine acetyltransferase; carnitine-acetyl-CoA transferase; CATC | |
| 2.3.1.8 | phosphate acetyltransferase | False | 49 | 22188 | 11 | 28 | acetyl-CoA + phosphate = CoA + acetyl phosphate | acetyl-CoA:phosphate acetyltransferase | None | phosphotransacetylase; phosphoacylase; PTA | |
| 2.3.1.9 | acetyl-CoA C-acetyltransferase | False | 74 | 55373 | 73 | 40 | 2 acetyl-CoA = CoA + acetoacetyl-CoA (overall reaction);;(1a) acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA;;(1b) [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + acetyl-CoA = acetoacetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine | acetyl-CoA:acetyl-CoA C-acetyltransferase | None | acetoacetyl-CoA thiolase; beta-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II; type II thiolase | |
| 2.3.1.10 | hydrogen-sulfide S-acetyltransferase | True | 0 | 0 | 0 | 2 | acetyl-CoA + hydrogen sulfide = CoA + thioacetate | acetyl-CoA:hydrogen-sulfide S-acetyltransferase | None | hydrogen-sulfide acetyltransferase | |
| 2.3.1.11 | thioethanolamine S-acetyltransferase | True | 0 | 0 | 0 | 2 | acetyl-CoA + 2-aminoethanethiol = CoA + S-(2-aminoethyl)thioacetate | acetyl-CoA:2-aminoethanethiol S-acetyltransferase | None | thioltransacetylase B; thioethanolamine acetyltransferase; acetyl-CoA:thioethanolamine S-acetyltransferase | |
| 2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase | False | 57 | 21075 | 47 | 24 | acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | None | acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoamide S-acetyltransferase; dihydrolipoate acetyltransferase; dihydrolipoic transacetylase; dihydrolipoyl acetyltransferase; lipoate acetyltransferase; lipoate transacetylase; lipoic acetyltransferase; lipoic acid acetyltransferase; lipoic transacetylase; lipoylacetyltransferase; thioltransacetylase A; transacetylase X; enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase; acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase | |
| 2.3.1.13 | glycine N-acyltransferase | False | 11 | 1 | 3 | 7 | acyl-CoA + glycine = CoA + N-acylglycine | acyl-CoA:glycine N-acyltransferase | None | glycine acyltransferase; glycine-N-acylase | |
| 2.3.1.14 | glutamine N-phenylacetyltransferase | True | 0 | 0 | 0 | 2 | phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine | phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase | None | glutamine phenylacetyltransferase; phenylacetyl-CoA:L-glutamine N-acetyltransferase | |
| 2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase | False | 221 | 9688 | 4 | 48 | acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate | acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase | None | alpha-glycerophosphate acyltransferase; 3-glycerophosphate acyltransferase; ACP:sn-glycerol-3-phosphate acyltransferase; glycerol 3-phosphate acyltransferase; glycerol phosphate acyltransferase; glycerol phosphate transacylase; glycerophosphate acyltransferase; glycerophosphate transacylase; sn-glycerol 3-phosphate acyltransferase; sn-glycerol-3-phosphate acyltransferase; glycerol-3-phosphate O-acyltransferase (ambiguous) | |
| 2.3.1.16 | acetyl-CoA C-acyltransferase | False | 226 | 41696 | 33 | 26 | acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (overall reaction);;(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine;;(1b) acyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine = [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + CoA | acyl-CoA:acetyl-CoA C-acyltransferase | None | beta-ketothiolase; 3-ketoacyl-CoA thiolase; KAT; beta-ketoacyl coenzyme A thiolase; beta-ketoacyl-CoA thiolase; beta-ketoadipyl coenzyme A thiolase; beta-ketoadipyl-CoA thiolase; 3-ketoacyl CoA thiolase; 3-ketoacyl coenzyme A thiolase; 3-ketoacyl thiolase; 3-ketothiolase; 3-oxoacyl-CoA thiolase; 3-oxoacyl-coenzyme A thiolase; 6-oxoacyl-CoA thiolase; acetoacetyl-CoA beta-ketothiolase; acetyl-CoA acyltransferase; ketoacyl-CoA acyltransferase; ketoacyl-coenzyme A thiolase; long-chain 3-oxoacyl-CoA thiolase; oxoacyl-coenzyme A thiolase; pro-3-ketoacyl-CoA thiolase; thiolase I; type I thiolase; 2-methylacetoacetyl-CoA thiolase [misleading] | |
| 2.3.1.17 | aspartate N-acetyltransferase | False | 5 | 780 | 0 | 5 | acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate | acetyl-CoA:L-aspartate N-acetyltransferase | None | aspartate acetyltransferase; L-aspartate N-acetyltransferase | |
| 2.3.1.18 | galactoside O-acetyltransferase | False | 2 | 790 | 11 | 2 | acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside | acetyl-CoA:beta-D-galactoside 6-acetyltransferase | None | thiogalactoside acetyltransferase; galactoside acetyltransferase; thiogalactoside transacetylase | |
| 2.3.1.19 | phosphate butyryltransferase | False | 3 | 1201 | 1 | 10 | butanoyl-CoA + phosphate = CoA + butanoyl phosphate | butanoyl-CoA:phosphate butanoyltransferase | None | phosphotransbutyrylase | |
| 2.3.1.20 | diacylglycerol O-acyltransferase | False | 114 | 22689 | 7 | 70 | acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol | acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase | None | diglyceride acyltransferase; 1,2-diacylglycerol acyltransferase; diacylglycerol acyltransferase; diglyceride O-acyltransferase; palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase; acyl-CoA:1,2-diacylglycerol O-acyltransferase | |
| 2.3.1.21 | carnitine O-palmitoyltransferase | False | 17 | 1854 | 9 | 23 | palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine | palmitoyl-CoA:L-carnitine O-palmitoyltransferase | None | CPT (ambiguous); CPTo; outer malonyl-CoA inhibitable carnitine palmitoyltransferase; CPTi; CPT I (outer membrane carnitine palmitoyl transferase); carnitine palmitoyltransferase I; carnitine palmitoyltransferase II; CPT-A; CPT-B; acylcarnitine transferase; carnitine palmitoyltransferase; carnitine palmitoyltransferase-A; L-carnitine palmitoyltransferase; palmitoylcarnitine transferase | |
| 2.3.1.22 | 2-acylglycerol O-acyltransferase | False | 18 | 222 | 0 | 14 | acyl-CoA + 2-acylglycerol = CoA + diacylglycerol | acyl-CoA:2-acylglycerol O-acyltransferase | None | acylglycerol palmitoyltransferase; monoglyceride acyltransferase; acyl coenzyme A-monoglyceride acyltransferase; monoacylglycerol acyltransferase | |
| 2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase | False | 43 | 2526 | 0 | 22 | acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase | None | lysolecithin acyltransferase; 1-acyl-sn-glycero-3-phosphocholine acyltransferase; acyl coenzyme A-monoacylphosphatidylcholine acyltransferase; acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase; lysophosphatide acyltransferase; lysophosphatidylcholine acyltransferase | |
| 2.3.1.24 | sphingosine N-acyltransferase | False | 17 | 222 | 3 | 13 | acyl-CoA + sphingosine = CoA + a ceramide | acyl-CoA:sphingosine N-acyltransferase | None | ceramide synthetase; sphingosine acyltransferase | |
| 2.3.1.25 | plasmalogen synthase | False | 8 | 19 | 0 | 4 | acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine | acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase | None | lysoplasmenylcholine acyltransferase; O-1-alkenylglycero-3-phosphorylcholine acyltransferase; 1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase | |
| 2.3.1.26 | sterol O-acyltransferase | False | 10 | 68 | 7 | 22 | a long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester | long-chain acyl-CoA:sterol O-acyltransferase | None | cholesterol acyltransferase; sterol-ester synthase; acyl coenzyme A-cholesterol-O-acyltransferase; acyl-CoA:cholesterol acyltransferase; ACAT; acylcoenzyme A:cholesterol O-acyltransferase; cholesterol ester synthase; cholesterol ester synthetase; cholesteryl ester synthetase; SOAT1 (gene name); SOAT2 (gene name); ARE1 (gene name); ARE2 (gene name); acyl-CoA:cholesterol O-acyltransferase | |
| 2.3.1.27 | cortisol O-acetyltransferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + cortisol = CoA + cortisol 21-acetate | acetyl-CoA:cortisol O-acetyltransferase | None | cortisol acetyltransferase; corticosteroid acetyltransferase; corticosteroid-21-O-acetyltransferase | |
| 2.3.1.28 | chloramphenicol O-acetyltransferase | False | 29 | 4189 | 14 | 25 | acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate | acetyl-CoA:chloramphenicol 3-O-acetyltransferase | None | chloramphenicol acetyltransferase; chloramphenicol acetylase; chloramphenicol transacetylase; CAT I; CAT II; CAT III | |
| 2.3.1.29 | glycine C-acetyltransferase | False | 8 | 14238 | 11 | 8 | acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoate | acetyl-CoA:glycine C-acetyltransferase | None | 2-amino-3-ketobutyrate CoA ligase; 2-amino-3-ketobutyrate coenzyme A ligase; 2-amino-3-ketobutyrate-CoA ligase; glycine acetyltransferase; aminoacetone synthase; aminoacetone synthetase; KBL; AKB ligase | |
| 2.3.1.30 | serine O-acetyltransferase | False | 43 | 33820 | 22 | 38 | acetyl-CoA + L-serine = CoA + O-acetyl-L-serine | acetyl-CoA:L-serine O-acetyltransferase | None | SATase; L-serine acetyltransferase; serine acetyltransferase; serine transacetylase | |
| 2.3.1.31 | homoserine O-acetyltransferase | False | 228 | 20937 | 13 | 19 | acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine | acetyl-CoA:L-homoserine O-acetyltransferase | None | homoserine acetyltransferase; homoserine transacetylase; homoserine-O-transacetylase; L-homoserine O-acetyltransferase | |
| 2.3.1.32 | lysine N-acetyltransferase | False | 0 | 5 | 0 | 6 | acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine | acetyl-phosphate:L-lysine N6-acetyltransferase | None | lysine acetyltransferase; acetyl-phosphate:L-lysine 6-N-acetyltransferase | |
| 2.3.1.33 | histidine N-acetyltransferase | False | 3 | 5 | 0 | 4 | acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine | acetyl-CoA:L-histidine N-acetyltransferase | None | acetylhistidine synthetase; histidine acetyltransferase | |
| 2.3.1.34 | D-tryptophan N-acetyltransferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + D-tryptophan = CoA + N-acetyl-D-tryptophan | acetyl-CoA:D-tryptophan N-acetyltransferase | None | D-tryptophan acetyltransferase; acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase | |
| 2.3.1.35 | glutamate N-acetyltransferase | False | 223 | 30572 | 9 | 18 | N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate | N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase | None | ornithine transacetylase; alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase; acetylglutamate synthetase; acetylglutamate-acetylornithine transacetylase; acetylglutamic synthetase; acetylglutamic-acetylornithine transacetylase; acetylornithine glutamate acetyltransferase; glutamate acetyltransferase; N-acetyl-L-glutamate synthetase; N-acetylglutamate synthase; N-acetylglutamate synthetase; ornithine acetyltransferase; 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase; acetylornithinase (ambiguous) | |
| 2.3.1.36 | D-amino-acid N-acetyltransferase | False | 1 | 12 | 0 | 1 | acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid | acetyl-CoA:D-amino-acid N-acetyltransferase | None | D-amino acid acetyltransferase; D-amino acid-alpha-N-acetyltransferase | |
| 2.3.1.37 | 5-aminolevulinate synthase | False | 40 | 10620 | 36 | 30 | succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | succinyl-CoA:glycine C-succinyltransferase (decarboxylating) | None | ALAS; ALA synthase; alpha-aminolevulinic acid synthase; delta-aminolevulinate synthase; delta-aminolevulinate synthetase; delta-aminolevulinic acid synthase; delta-aminolevulinic acid synthetase; delta-aminolevulinic synthetase; 5-aminolevulinate synthetase; 5-aminolevulinic acid synthetase; ALA synthetase; aminolevulinate synthase; aminolevulinate synthetase; aminolevulinic acid synthase; aminolevulinic acid synthetase; aminolevulinic synthetase | |
| 2.3.1.38 | [acyl-carrier-protein] S-acetyltransferase | False | 18 | 1404 | 2 | 11 | acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein] | acetyl-CoA:[acyl-carrier protein] S-acetyltransferase | None | acetyl coenzyme A-acyl-carrier-protein transacylase; [acyl-carrier-protein]-acetyltransferase; [ACP]-acetyltransferase; acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase | |
| 2.3.1.39 | [acyl-carrier-protein] S-malonyltransferase | False | 49 | 50003 | 34 | 34 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] | malonyl-CoA:[acyl-carrier protein] S-malonyltransferase | None | [acyl carrier protein]malonyltransferase; FabD; malonyl coenzyme A-acyl carrier protein transacylase; malonyl transacylase; malonyl transferase; malonyl-CoA-acyl carrier protein transacylase; malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase; malonyl-CoA:ACP transacylase; malonyl-CoA:ACP-SH transacylase; malonyl-CoA:AcpM transacylase; malonyl-CoA:acyl carrier protein transacylase; malonyl-CoA:acyl-carrier-protein transacylase; malonyl-CoA/dephospho-CoA acyltransferase; MAT; MCAT; MdcH | |
| 2.3.1.40 | acyl-[acyl-carrier-protein]---phospholipid O-acyltransferase | False | 56 | 1736 | 0 | 2 | an acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = an [acyl-carrier protein] + O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine | acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)ethanolamine O-acyltransferase | None | acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase | |
| 2.3.1.41 | beta-ketoacyl-[acyl-carrier-protein] synthase I | False | 41 | 24832 | 123 | 35 | an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating) | None | beta-ketoacyl-ACP synthase I; beta-ketoacyl synthetase; beta-ketoacyl-ACP synthetase; beta-ketoacyl-acyl carrier protein synthetase; beta-ketoacyl-[acyl carrier protein] synthase; beta-ketoacylsynthase; condensing enzyme (ambiguous); 3-ketoacyl-acyl carrier protein synthase; fatty acid condensing enzyme; acyl-malonyl(acyl-carrier-protein)-condensing enzyme; acyl-malonyl acyl carrier protein-condensing enzyme; beta-ketoacyl acyl carrier protein synthase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl:ACP synthase I; KASI; KAS I; FabF1; FabB; acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) | |
| 2.3.1.42 | glycerone-phosphate O-acyltransferase | False | 7 | 826 | 0 | 11 | acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate | acyl-CoA:glycerone-phosphate O-acyltransferase | None | dihydroxyacetone phosphate acyltransferase (ambiguous) | |
| 2.3.1.43 | phosphatidylcholine---sterol O-acyltransferase | False | 12 | 1264 | 9 | 16 | phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester | phosphatidylcholine:sterol O-acyltransferase | None | lecithin---cholesterol acyltransferase; phospholipid---cholesterol acyltransferase; LCAT (lecithin-cholesterol acyltransferase); lecithin:cholesterol acyltransferase; lysolecithin acyltransferase | |
| 2.3.1.44 | N-acetylneuraminate 4-O-acetyltransferase | True | 0 | 0 | 0 | 4 | acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate | acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase | None | sialate O-acetyltransferase | |
| 2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase | False | 3 | 26 | 0 | 12 | acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate | acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase | None | N-acetylneuraminate 7(8)-O-acetyltransferase; sialate O-acetyltransferase; N-acetylneuraminate 7,8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase; glycoprotein 7(9)-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase; N-acetylneuraminate O7-(or O9-)acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase | |
| 2.3.1.46 | homoserine O-succinyltransferase | False | 208 | 8155 | 5 | 4 | succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine | succinyl-CoA:L-homoserine O-succinyltransferase | None | homoserine O-transsuccinylase (ambiguous); homoserine succinyltransferase | |
| 2.3.1.47 | 8-amino-7-oxononanoate synthase | False | 304 | 26496 | 14 | 23 | pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein] | 6-carboxyhexanoyl-[acyl-carrier protein]:L-alanine C-carboxyhexanoyltransferase (decarboxylating) | None | 7-keto-8-aminopelargonic acid synthetase; 7-keto-8-aminopelargonic synthetase; 8-amino-7-oxopelargonate synthase; bioF (gene name) | |
| 2.3.1.48 | histone acetyltransferase | False | 160 | 40719 | 556 | 38 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | acetyl-CoA:[protein]-L-lysine acetyltransferase | None | nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase; lysine acetyltransferase; protein lysine acetyltransferase; acetyl-CoA:histone acetyltransferase | |
| 2.3.1.49 | deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase | True | 0 | 0 | 0 | 1 | S-acetylphosphopantetheine + holo-[citrate (pro-3S)-lyase] = phosphopantetheine + acetyl-[citrate (pro-3S)-lyase] | S-acetylphosphopantetheine:holo-[citrate (pro-3S)-lyase] S-acetyltransferase | None | S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase; deacetyl-[citrate-(pro-3S)-lyase] acetyltransferase; S-acetylphosphopantetheine:deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)] S-acetyltransferase | |
| 2.3.1.50 | serine C-palmitoyltransferase | False | 40 | 5030 | 41 | 19 | palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2 | palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) | None | serine palmitoyltransferase; SPT; 3-oxosphinganine synthetase; acyl-CoA:serine C-2 acyltransferase decarboxylating | |
| 2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase | False | 87 | 26859 | 2 | 34 | acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate | acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase | None | 1-acyl-sn-glycero-3-phosphate acyltransferase; 1-acyl-sn-glycerol 3-phosphate acyltransferase; 1-acylglycero-3-phosphate acyltransferase; 1-acylglycerolphosphate acyltransferase; 1-acylglycerophosphate acyltransferase; lysophosphatidic acid-acyltransferase | |
| 2.3.1.52 | 2-acylglycerol-3-phosphate O-acyltransferase | True | 0 | 0 | 0 | 6 | acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate | acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase | None | 2-acylglycerophosphate acyltransferase | |
| 2.3.1.53 | phenylalanine N-acetyltransferase | False | 1 | 2 | 0 | 1 | acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine | acetyl-CoA:L-phenylalanine N-acetyltransferase | None | acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase | |
| 2.3.1.54 | formate C-acetyltransferase | False | 19 | 12202 | 8 | 30 | acetyl-CoA + formate = CoA + pyruvate | acetyl-CoA:formate C-acetyltransferase | None | pyruvate formate-lyase; pyruvic formate-lyase; formate acetyltransferase | |
| 2.3.1.56 | aromatic-hydroxylamine O-acetyltransferase | True | 0 | 0 | 0 | 7 | N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl | N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase | None | aromatic hydroxylamine acetyltransferase; arylhydroxamate acyltransferase; arylhydroxamate N,O-acetyltransferase; arylhydroxamic acid N,O-acetyltransferase; arylhydroxamic acyltransferase; N,O-acetyltransferase; N-hydroxy-2-acetylaminofluorene N-O acyltransferase | |
| 2.3.1.57 | diamine N-acetyltransferase | False | 25 | 3650 | 31 | 16 | acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine | acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase | None | spermidine acetyltransferase; putrescine acetyltransferase; putrescine (diamine)-acetylating enzyme; diamine acetyltransferase; spermidine/spermine N1-acetyltransferase; spermidine N1-acetyltransferase; acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase; putrescine acetylase; putrescine N-acetyltransferase | |
| 2.3.1.58 | 2,3-diaminopropionate N-oxalyltransferase | False | 0 | 3 | 0 | 1 | oxalyl-CoA + L-2,3-diaminopropanoate = CoA + N3-oxalyl-L-2,3-diaminopropanoate | oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase | None | oxalyldiaminopropionate synthase; ODAP synthase; oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase; oxalyldiaminopropionic synthase; oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase | |
| 2.3.1.59 | gentamicin 2'-N-acetyltransferase | False | 1 | 53 | 6 | 6 | acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a | acetyl-CoA:gentamicin-C1a N2'-acetyltransferase | None | gentamycin acetyltransferase II; gentamycin 2'-N-acetyltransferase; acetyl-CoA:gentamycin-C1a N2'-acetyltransferase | |
| 2.3.1.60 | gentamicin 3-N-acetyltransferase | False | 1 | 50 | 0 | 4 | acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C | acetyl-CoA:gentamicin-C N3-acetyltransferase | None | gentamycin acetyltransferase I; aminoglycoside acetyltransferase AAC(3)-1; gentamycin 3-N-acetyltransferase; acetyl-CoA:gentamycin-C N3-acetyltransferase; acetyl-CoA:gentamicin-C N3'-acetyltransferase (incorrect); gentamicin 3'-N-acetyltransferase (incorrect) | |
| 2.3.1.61 | dihydrolipoyllysine-residue succinyltransferase | False | 59 | 27853 | 17 | 31 | succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine | succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase | None | dihydrolipoamide S-succinyltransferase; dihydrolipoamide succinyltransferase; dihydrolipoic transsuccinylase; dihydrolipolyl transsuccinylase; dihydrolipoyl transsuccinylase; lipoate succinyltransferase (Escherichia coli); lipoic transsuccinylase; lipoyl transsuccinylase; succinyl-CoA:dihydrolipoamide S-succinyltransferase; succinyl-CoA:dihydrolipoate S-succinyltransferase; enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase | |
| 2.3.1.62 | 2-acylglycerophosphocholine O-acyltransferase | False | 2 | 0 | 0 | 8 | acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine = CoA + phosphatidylcholine | acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase | None | 2-acylglycerol-3-phosphorylcholine acyltransferase; 2-acylglycerophosphocholine acyltransferase | |
| 2.3.1.63 | 1-alkylglycerophosphocholine O-acyltransferase | True | 0 | 0 | 0 | 3 | acyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphocholine | acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase | None | None | |
| 2.3.1.64 | agmatine N4-coumaroyltransferase | False | 3 | 8 | 1 | 3 | 4-coumaroyl-CoA + agmatine = CoA + N-(4-guanidinobutyl)-4-hydroxycinnamamide | 4-coumaroyl-CoA:agmatine N4-coumaroyltransferase | None | p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase; agmatine coumaroyltransferase; 4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase | |
| 2.3.1.65 | bile acid-CoA:amino acid N-acyltransferase | False | 3 | 4 | 0 | 9 | choloyl-CoA + glycine = CoA + glycocholate | choloyl-CoA:glycine N-choloyltransferase | None | glycine---taurine N-acyltransferase; amino acid N-choloyltransferase; BAT; glycine N-choloyltransferase; BACAT; cholyl-CoA glycine-taurine N-acyltransferase; cholyl-CoA:taurine N-acyltransferase | |
| 2.3.1.66 | leucine N-acetyltransferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine | acetyl-CoA:L-leucine N-acetyltransferase | None | leucine acetyltransferase | |
| 2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase | False | 12 | 26 | 0 | 7 | acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase | None | acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-alkyl-2-lysolecithin acetyltransferase; acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase; blood platelet-activating factor acetyltransferase; lyso-GPC:acetyl CoA acetyltransferase; lyso-platelet activating factor:acetyl-CoA acetyltransferase; lysoPAF:acetyl CoA acetyltransferase; PAF acetyltransferase; platelet-activating factor acylhydrolase; platelet-activating factor-synthesizing enzyme; 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase; lyso-platelet-activating factor:acetyl-CoA acetyltransferase | |
| 2.3.1.68 | glutamine N-acyltransferase | False | 2 | 0 | 0 | 2 | acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine | acyl-CoA:L-glutamine N-acyltransferase | None | None | |
| 2.3.1.69 | monoterpenol O-acetyltransferase | False | 0 | 1 | 0 | 1 | acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester | acetyl-CoA:monoterpenol O-acetyltransferase | None | menthol transacetylase | |
| 2.3.1.71 | glycine N-benzoyltransferase | False | 5 | 0 | 0 | 4 | benzoyl-CoA + glycine = CoA + hippurate | benzoyl-CoA:glycine N-benzoyltransferase | None | benzoyl CoA-amino acid N-acyltransferase; benzoyl-CoA:glycine N-acyltransferase | |
| 2.3.1.72 | indoleacetylglucose---inositol O-acyltransferase | False | 0 | 5 | 0 | 2 | 1-O-(indol-3-yl)acetyl-beta-D-glucose + myo-inositol = D-glucose + O-(indol-3-yl)acetyl-myo-inositol | 1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase | None | indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase; 1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase | |
| 2.3.1.73 | diacylglycerol---sterol O-acyltransferase | True | 0 | 0 | 0 | 1 | a 1,2-diacyl-sn-glycerol + sterol = a 1-acyl-sn-glycerol + sterol ester | 1,2-diacyl-sn-glycerol:sterol O-acyltransferase | None | 1,2-diacyl-sn-glycerol:sterol acyl transferase | |
| 2.3.1.74 | chalcone synthase | False | 140 | 2061 | 38 | 65 | 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) | None | naringenin-chalcone synthase; flavanone synthase; 6'-deoxychalcone synthase; chalcone synthetase; DOCS; CHS | |
| 2.3.1.75 | long-chain-alcohol O-fatty-acyltransferase | False | 30 | 180 | 0 | 15 | acyl-CoA + a long-chain alcohol = CoA + a long-chain ester | acyl-CoA:long-chain-alcohol O-acyltransferase | None | wax synthase; wax-ester synthase | |
| 2.3.1.76 | retinol O-fatty-acyltransferase | False | 16 | 216 | 0 | 7 | acyl-CoA + retinol = CoA + retinyl ester | acyl-CoA:retinol O-acyltransferase | None | retinol acyltransferase; retinol fatty-acyltransferase | |
| 2.3.1.77 | triacylglycerol---sterol O-acyltransferase | True | 0 | 0 | 0 | 1 | triacylglycerol + a 3beta-hydroxysteroid = diacylglycerol + a 3beta-hydroxysteroid ester | triacylglycerol:3beta-hydroxysteroid O-acyltransferase | None | triacylglycerol:sterol acyltransferase | |
| 2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase | False | 2 | 119 | 11 | 3 | acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase | None | acetyl-CoA:alpha-glucosaminide N-acetyltransferase | |
| 2.3.1.79 | maltose O-acetyltransferase | False | 2 | 2052 | 8 | 2 | acetyl-CoA + maltose = CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose | acetyl-CoA:maltose O-acetyltransferase | None | maltose transacetylase; maltose O-acetyltransferase; MAT | |
| 2.3.1.80 | cysteine-S-conjugate N-acetyltransferase | False | 4 | 2 | 0 | 3 | acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate | acetyl-CoA:S-substituted L-cysteine N-acetyltransferase | None | None | |
| 2.3.1.81 | aminoglycoside 3-N-acetyltransferase | False | 10 | 72 | 29 | 15 | acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic | acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase | None | 3-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase; aminoglycoside N3-acetyltransferase; acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase (incorrect); aminoglycoside N3'-acetyltransferase (incorrect) | |
| 2.3.1.82 | aminoglycoside 6'-N-acetyltransferase | False | 12 | 2488 | 14 | 27 | acetyl-CoA + kanamycin-B = CoA + N6'-acetylkanamycin-B | acetyl-CoA:kanamycin-B N6'-acetyltransferase | None | aminoglycoside N6'-acetyltransferase; aminoglycoside-6'-acetyltransferase; aminoglycoside-6-N-acetyltransferase; kanamycin acetyltransferase | |
| 2.3.1.83 | phosphatidylcholine---dolichol O-acyltransferase | True | 0 | 0 | 0 | 1 | 3-sn-phosphatidylcholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol | 3-sn-phosphatidylcholine:dolichol O-acyltransferase | None | None | |
| 2.3.1.84 | alcohol O-acetyltransferase | False | 4 | 127 | 0 | 20 | acetyl-CoA + an alcohol = CoA + an acetyl ester | acetyl-CoA:alcohol O-acetyltransferase | None | alcohol acetyltransferase | |
| 2.3.1.85 | fatty-acid synthase system | False | 8 | 3835 | 18 | 19 | acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) | None | FASN (gene name); fatty-acid synthase | |
| 2.3.1.86 | fatty-acyl-CoA synthase system | False | 30 | 2191 | 34 | 16 | acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) | None | yeast fatty acid synthase; FAS1 (gene name); FAS2 (gene name); fatty-acyl-CoA synthase | |
| 2.3.1.87 | aralkylamine N-acetyltransferase | False | 16 | 1346 | 25 | 42 | acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine | acetyl-CoA:2-arylethylamine N-acetyltransferase | None | serotonin acetyltransferase; serotonin acetylase; arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase; AANAT; melatonin rhythm enzyme | |
| 2.3.1.89 | tetrahydrodipicolinate N-acetyltransferase | False | 125 | 3990 | 2 | 1 | acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + L-2-acetamido-6-oxoheptanedioate | acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N2-acetyltransferase | None | tetrahydrodipicolinate acetylase; tetrahydrodipicolinate:acetyl-CoA acetyltransferase; acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase; acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase | |
| 2.3.1.90 | beta-glucogallin O-galloyltransferase | True | 0 | 0 | 0 | 1 | 2 1-O-galloyl-beta-D-glucose = D-glucose + 1-O,6-O-digalloyl-beta-D-glucose | 1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase | None | None | |
| 2.3.1.91 | sinapoylglucose---choline O-sinapoyltransferase | False | 1 | 7 | 0 | 24 | 1-O-sinapoyl-beta-D-glucose + choline = D-glucose + sinapoylcholine | 1-O-sinapoyl-beta-D-glucose:choline 1-O-sinapoyltransferase | None | sinapine synthase | |
| 2.3.1.92 | sinapoylglucose---malate O-sinapoyltransferase | False | 1 | 0 | 0 | 4 | 1-O-sinapoyl-beta-D-glucose + (S)-malate = D-glucose + sinapoyl-(S)-malate | 1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase | None | 1-sinapoylglucose-L-malate sinapoyltransferase; sinapoylglucose:malate sinapoyltransferase | |
| 2.3.1.93 | 13-hydroxylupanine O-tigloyltransferase | False | 1 | 4 | 0 | 4 | (E)-2-methylcrotonoyl-CoA + 13-hydroxylupanine = CoA + 13-[(E)-2-methylcrotonoyl]oxylupanine | (E)-2-methylcrotonoyl-CoA:13-hydroxylupanine O-2-methylcrotonoyltransferase | None | tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase; 13-hydroxylupanine acyltransferase | |
| 2.3.1.94 | 6-deoxyerythronolide-B synthase | False | 3 | 978 | 29 | 1 | propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ | propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing) | None | erythronolide condensing enzyme; malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing); erythronolide synthase; malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing); deoxyerythronolide B synthase; 6-deoxyerythronolide B synthase; DEBS | |
| 2.3.1.95 | trihydroxystilbene synthase | False | 9 | 354 | 2 | 18 | 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO2 | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) | None | resveratrol synthase; stilbene synthase (ambiguous) | |
| 2.3.1.97 | glycylpeptide N-tetradecanoyltransferase | False | 36 | 6620 | 141 | 22 | tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] | tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase | None | NMT (gene name); peptide N-myristoyltransferase; myristoyl-CoA-protein N-myristoyltransferase; myristoyl-coenzyme A:protein N-myristoyl transferase; myristoylating enzymes; protein N-myristoyltransferase; tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase | |
| 2.3.1.98 | chlorogenate---glucarate O-hydroxycinnamoyltransferase | False | 0 | 8 | 0 | 1 | chlorogenate + glucarate = quinate + 2-O-caffeoylglucarate | chlorogenate:glucarate O-(hydroxycinnamoyl)transferase | None | chlorogenate:glucarate caffeoyltransferase; chlorogenic acid:glucaric acid O-caffeoyltransferase; chlorogenate:glucarate caffeoyltransferase | |
| 2.3.1.99 | quinate O-hydroxycinnamoyltransferase | False | 0 | 45 | 1 | 19 | feruloyl-CoA + quinate = CoA + O-feruloylquinate | feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase | None | hydroxycinnamoyl coenzyme A-quinate transferase | |
| 2.3.1.100 | [myelin-proteolipid] O-palmitoyltransferase | True | 0 | 0 | 0 | 1 | palmitoyl-CoA + [myelin proteolipid] = CoA + O-palmitoyl-[myelin proteolipid] | palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase | None | myelin PLP acyltransferase; acyl-protein synthetase; myelin-proteolipid O-palmitoyltransferase | |
| 2.3.1.101 | formylmethanofuran---tetrahydromethanopterin N-formyltransferase | False | 13 | 2604 | 6 | 10 | formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin | formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase | None | formylmethanofuran-tetrahydromethanopterin formyltransferase; formylmethanofuran:tetrahydromethanopterin formyltransferase; N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase; FTR; formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase | |
| 2.3.1.102 | N6-hydroxylysine N-acetyltransferase | False | 1 | 191 | 0 | 1 | acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine | acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase | None | N6-hydroxylysine:acetyl CoA N6-transacetylase; N6-hydroxylysine acetylase; acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase; N6-hydroxylysine O-acetyltransferase (incorrect) | |
| 2.3.1.103 | sinapoylglucose---sinapoylglucose O-sinapoyltransferase | False | 3 | 20 | 0 | 1 | 2 1-O-sinapoyl-beta-D-glucose = D-glucose + 1,2-bis-O-sinapoyl-beta-D-glucose | 1-O-sinapoyl-beta-D-glucose:1-O-sinnapoyl-beta-D-glucose 1-O-sinapoyltransferase | None | hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase; 1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase; 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside 1-O-sinapoyltransferase | |
| 2.3.1.105 | alkylglycerophosphate 2-O-acetyltransferase | True | 0 | 0 | 0 | 3 | acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate | acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase | None | alkyllyso-GP:acetyl-CoA acetyltransferase | |
| 2.3.1.106 | tartronate O-hydroxycinnamoyltransferase | True | 0 | 0 | 0 | 1 | sinapoyl-CoA + 2-hydroxymalonate = CoA + sinapoyltartronate | sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase | None | tartronate sinapoyltransferase; hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase | |
| 2.3.1.107 | deacetylvindoline O-acetyltransferase | False | 1 | 36 | 0 | 1 | acetyl-CoA + deacetylvindoline = CoA + vindoline | acetyl-CoA:deacetylvindoline 4-O-acetyltransferase | None | deacetylvindoline acetyltransferase; DAT; 17-O-deacetylvindoline-17-O-acetyltransferase; acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase; acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase; acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase; acetylcoenzyme A:deacetylvindoline O-acetyltransferase; 17-O-deacetylvindoline O-acetyltransferase; acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase | |
| 2.3.1.108 | alpha-tubulin N-acetyltransferase | False | 32 | 1889 | 14 | 11 | acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine | acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase | None | ATAT1 (gene name); MEC17 (gene name); alpha-tubulin acetylase; TAT; alpha-tubulin acetyltransferase; tubulin N-acetyltransferase (ambiguous); acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase; acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase | |
| 2.3.1.109 | arginine N-succinyltransferase | False | 53 | 5034 | 1 | 8 | succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine | succinyl-CoA:L-arginine N2-succinyltransferase | None | arginine succinyltransferase; AstA; arginine and ornithine N2-succinyltransferase; AOST; AST (ambiguous); succinyl-CoA:L-arginine 2-N-succinyltransferase | |
| 2.3.1.110 | tyramine N-feruloyltransferase | False | 2 | 14 | 0 | 7 | feruloyl-CoA + tyramine = CoA + N-feruloyltyramine | feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase | None | tyramine N-feruloyl-CoA transferase; feruloyltyramine synthase; feruloyl-CoA tyramine N-feruloyl-CoA transferase; tyramine feruloyltransferase | |
| 2.3.1.111 | mycocerosate synthase | False | 1 | 316 | 8 | 2 | (1) a long-chain acyl-[mycocerosic acid synthase] + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CoA + 3 CO2 + 6 NADP+ + 3 H2O;;(2) a long-chain acyl-[mycocerosic acid synthase] + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ = a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O | long-chain acyl-[mycocerosic acid synthase]:methylmalonyl-CoA C-acyltransferase (mycocerosate-forming) | None | mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing); long-chain acyl-CoA:methylmalonyl-CoA C-acyltransferase (mycocerosate-forming) | |
| 2.3.1.112 | D-tryptophan N-malonyltransferase | True | 0 | 0 | 0 | 1 | malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan | malonyl-CoA:D-tryptophan N-malonyltransferase | None | None | |
| 2.3.1.113 | anthranilate N-malonyltransferase | True | 0 | 0 | 0 | 1 | malonyl-CoA + anthranilate = CoA + N-malonylanthranilate | malonyl-CoA:anthranilate N-malonyltransferase | None | None | |
| 2.3.1.114 | 3,4-dichloroaniline N-malonyltransferase | True | 0 | 0 | 0 | 3 | malonyl-CoA + 3,4-dichloroaniline = CoA + N-(3,4-dichlorophenyl)-malonamate | malonyl-CoA:3,4-dichloroaniline N-malonyltransferase | None | None | |
| 2.3.1.115 | isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase | False | 0 | 37 | 0 | 4 | malonyl-CoA + biochanin A 7-O-beta-D-glucoside = CoA + biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) | malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase | None | flavone/flavonol 7-O-beta-D-glucoside malonyltransferase; flavone (flavonol) 7-O-glycoside malonyltransferase; malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase; MAT-7; malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase; malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase | |
| 2.3.1.116 | flavonol-3-O-beta-glucoside O-malonyltransferase | False | 3 | 0 | 0 | 3 | malonyl-CoA + flavonol 3-O-beta-D-glucoside = CoA + flavonol 3-O-(6-O-malonyl-beta-D-glucoside) | malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase | None | flavonol 3-O-glucoside malonyltransferase; MAT-3; malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase | |
| 2.3.1.117 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | False | 278 | 21096 | 22 | 5 | succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate | succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | None | tetrahydropicolinate succinylase; tetrahydrodipicolinate N-succinyltransferase; tetrahydrodipicolinate succinyltransferase; succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase; succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | |
| 2.3.1.118 | N-hydroxyarylamine O-acetyltransferase | False | 9 | 1331 | 3 | 8 | acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine | acetyl-CoA:N-hydroxyarylamine O-acetyltransferase | None | arylhydroxamate N,O-acetyltransferase; arylamine N-acetyltransferase; N-hydroxy-2-aminofluorene-O-acetyltransferase | |
| 2.3.1.121 | 1-alkenylglycerophosphoethanolamine O-acyltransferase | False | 4 | 0 | 0 | 2 | acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine | acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase | None | None | |
| 2.3.1.122 | trehalose O-mycolyltransferase | False | 25 | 2314 | 14 | 6 | 2 alpha,alpha-trehalose 6-mycolate = alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate | alpha,alpha-trehalose-6-mycolate:alpha,alpha-trehalose-6-mycolate 6'-mycolyltransferase | None | alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase; alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase | |
| 2.3.1.123 | dolichol O-acyltransferase | True | 0 | 0 | 0 | 1 | palmitoyl-CoA + dolichol = CoA + dolichyl palmitate | palmitoyl-CoA:dolichol O-palmitoyltransferase | None | acyl-CoA:dolichol acyltransferase | |
| 2.3.1.125 | 1-alkyl-2-acetylglycerol O-acyltransferase | True | 0 | 0 | 0 | 1 | acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol = CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol | acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase | None | 1-hexadecyl-2-acetylglycerol acyltransferase | |
| 2.3.1.126 | isocitrate O-dihydroxycinnamoyltransferase | True | 0 | 0 | 0 | 4 | caffeoyl-CoA + isocitrate = CoA + 2-O-caffeoylisocitrate | caffeoyl-CoA:isocitrate 2-O-(3,4-dihydroxycinnamoyl)transferase | None | None | |
| 2.3.1.127 | ornithine N-benzoyltransferase | True | 0 | 0 | 0 | 5 | 2 benzoyl-CoA + L-ornithine = 2 CoA + N2,N5-dibenzoyl-L-ornithine | benzoyl-CoA:L-ornithine N-benzoyltransferase | None | ornithine N-acyltransferase | |
| 2.3.1.129 | acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase | False | 268 | 20950 | 48 | 24 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine = an [acyl-carrier protein] + a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine | (3R)-3-hydroxyacyl-[acyl-carrier protein]:UDP-N-acetyl-alpha-D-glucosamine 3-O-(3-hydroxyacyl)transferase | None | lpxA (gene name); UDP-N-acetylglucosamine acyltransferase; uridine diphosphoacetylglucosamine acyltransferase; acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase; (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase | |
| 2.3.1.130 | galactarate O-hydroxycinnamoyltransferase | False | 0 | 1 | 0 | 1 | feruloyl-CoA + galactarate = CoA + O-feruloylgalactarate | feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase | None | galacturate hydroxycinnamoyltransferase | |
| 2.3.1.131 | glucarate O-hydroxycinnamoyltransferase | False | 0 | 1 | 0 | 1 | sinapoyl-CoA + glucarate = CoA + O-sinapoylglucarate | sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase | None | None | |
| 2.3.1.132 | glucarolactone O-hydroxycinnamoyltransferase | True | 0 | 0 | 0 | 1 | sinapoyl-CoA + glucarolactone = CoA + O-sinapoylglucarolactone | sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase | None | None | |
| 2.3.1.133 | shikimate O-hydroxycinnamoyltransferase | False | 2 | 248 | 7 | 26 | 4-coumaroyl-CoA + shikimate = CoA + 4-coumaroylshikimate | 4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase | None | shikimate hydroxycinnamoyltransferase | |
| 2.3.1.134 | galactolipid O-acyltransferase | True | 0 | 0 | 0 | 2 | 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyldiacylglycerol + mono-beta-D-galactosylacylglycerol | mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase | None | galactolipid:galactolipid acyltransferase | |
| 2.3.1.135 | phosphatidylcholine---retinol O-acyltransferase | False | 4 | 10 | 1 | 7 | phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] | phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase | None | lecithin---retinol acyltransferase; phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase; lecithin:retinol acyltransferase; lecithin-retinol acyltransferase; retinyl ester synthase; LRAT; lecithin retinol acyl transferase | |
| 2.3.1.136 | polysialic-acid O-acetyltransferase | False | 1 | 27 | 1 | 2 | acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9 | acetyl-CoA:polysialic-acid O-acetyltransferase | None | None | |
| 2.3.1.137 | carnitine O-octanoyltransferase | False | 8 | 15 | 4 | 10 | octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine | octanoyl-CoA:L-carnitine O-octanoyltransferase | None | medium-chain/long-chain carnitine acyltransferase; carnitine medium-chain acyltransferase; easily solubilized mitochondrial carnitine palmitoyltransferase; overt mitochondrial carnitine palmitoyltransferase | |
| 2.3.1.138 | putrescine N-hydroxycinnamoyltransferase | True | 0 | 0 | 0 | 5 | caffeoyl-CoA + putrescine = CoA + N-caffeoylputrescine | caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase | None | caffeoyl-CoA putrescine N-caffeoyl transferase; PHT; putrescine hydroxycinnamoyl transferase; hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase; putrescine hydroxycinnamoyltransferase | |
| 2.3.1.139 | ecdysone O-acyltransferase | True | 0 | 0 | 0 | 1 | palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate | palmitoyl-CoA:ecdysone palmitoyltransferase | None | acyl-CoA:ecdysone acyltransferase; fatty acyl-CoA:ecdysone acyltransferase | |
| 2.3.1.140 | rosmarinate synthase | False | 2 | 4 | 1 | 4 | caffeoyl-CoA + (R)-3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate | caffeoyl-CoA:(R)-3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase | None | rosmarinic acid synthase; caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase; 4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase; RAS (gene name) | |
| 2.3.1.141 | galactosylacylglycerol O-acyltransferase | True | 0 | 0 | 0 | 1 | an acyl-[acyl-carrier protein] + a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = an [acyl-carrier protein] + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol | acyl-[acyl-carrier protein]:2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol O-acyltransferase | None | acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase; acyl-ACP:lyso-MGDG acyltransferase; acyl-[acyl-carrier-protein]:D-galactosylacylglycerol O-acyltransferase | |
| 2.3.1.142 | glycoprotein O-fatty-acyltransferase | False | 0 | 2 | 0 | 8 | palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein | fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase | None | protein acyltransferase | |
| 2.3.1.143 | beta-glucogallin---tetrakisgalloylglucose O-galloyltransferase | True | 0 | 0 | 0 | 1 | 1-O-galloyl-beta-D-glucose + 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose = D-glucose + 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | 1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase | None | beta-glucogallin-tetragalloylglucose 4-galloyltransferase; beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase; beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase | |
| 2.3.1.144 | anthranilate N-benzoyltransferase | False | 3 | 34 | 0 | 1 | benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate | benzoyl-CoA:anthranilate N-benzoyltransferase | None | None | |
| 2.3.1.145 | piperidine N-piperoyltransferase | False | 2 | 0 | 0 | 1 | (E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine | (E,E)-piperoyl-CoA:piperidine N-piperoyltransferase | None | piperidine piperoyltransferase; piperoyl-CoA:piperidine N-piperoyltransferase | |
| 2.3.1.146 | pinosylvin synthase | False | 3 | 9 | 0 | 4 | 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2 | malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing) | None | stilbene synthase (ambiguous); pine stilbene synthase (ambiguous) | |
| 2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) | True | 0 | 0 | 0 | 4 | 1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine | 1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent) | None | None | |
| 2.3.1.148 | glycerophospholipid acyltransferase (CoA-dependent) | True | 0 | 0 | 0 | 5 | 1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine | 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent) | None | None | |
| 2.3.1.149 | platelet-activating factor acetyltransferase | False | 4 | 0 | 0 | 2 | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase | None | PAF acetyltransferase | |
| 2.3.1.150 | salutaridinol 7-O-acetyltransferase | False | 1 | 52 | 0 | 3 | acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol | acetyl-CoA:salutaridinol 7-O-acetyltransferase | None | None | |
| 2.3.1.151 | 2,3',4,6-tetrahydroxybenzophenone synthase | False | 1 | 2 | 1 | 4 | 3 malonyl-CoA + 3-hydroxybenzoyl-CoA = 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 | malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase (decarboxylating, 2,3',4,6-tetrahydroxybenzophenone-forming) | None | benzophenone synthase (ambiguous); BPS (ambiguous) | |
| 2.3.1.152 | alcohol O-cinnamoyltransferase | True | 0 | 0 | 0 | 1 | 1-O-trans-cinnamoyl-beta-D-glucopyranose + ROH = alkyl cinnamate + glucose | 1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase | None | None | |
| 2.3.1.153 | anthocyanin 5-(6'''-hydroxycinnamoyltransferase) | False | 1 | 10 | 2 | 4 | 4-hydroxycinnamoyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = CoA + anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-(6-O-4-hydroxycinnamoylglucoside) | 4-hydroxycinnamoyl-CoA:anthocyanidin 3,5-di-O-beta-D-glucoside 5-O-glucoside-6'''-O-4-hydroxycinnamoyltransferase | None | None | |
| 2.3.1.155 | acetyl-CoA C-myristoyltransferase | False | 17 | 2829 | 0 | 8 | myristoyl-CoA + acetyl-CoA = CoA + 3-oxopalmitoyl-CoA | myristoyl-CoA:acetyl-CoA C-myristoyltransferase | None | None | |
| 2.3.1.156 | phloroisovalerophenone synthase | False | 3 | 3 | 0 | 5 | (1) isovaleryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO2 + phlorisovalerophenone;;(2) isobutyryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO2 + phlorisobutyrophenone | acyl-CoA:malonyl-CoA acyltransferase | None | valerophenone synthase; 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase; acylphloroglucinol synthase; isovaleryl-CoA:malonyl-CoA acyltransferase | |
| 2.3.1.157 | glucosamine-1-phosphate N-acetyltransferase | False | 603 | 29892 | 7 | 12 | acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase | None | None | |
| 2.3.1.158 | phospholipid:diacylglycerol acyltransferase | False | 4 | 246 | 0 | 15 | phospholipid + 1,2-diacyl-sn-glycerol = lysophospholipid + triacylglycerol | phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase | None | PDAT | |
| 2.3.1.159 | acridone synthase | False | 3 | 1 | 1 | 3 | 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 | malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing) | None | None | |
| 2.3.1.160 | vinorine synthase | False | 1 | 82 | 1 | 1 | acetyl-CoA + 16-epivellosimine = CoA + vinorine | acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing) | None | None | |
| 2.3.1.161 | lovastatin nonaketide synthase | False | 5 | 53 | 3 | 1 | 9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O | acyl-CoA:malonyl-CoA C-acyltransferase (dihydromonacolin L acid-forming) | None | LNKS; LovB; LovC; acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) | |
| 2.3.1.162 | taxadien-5alpha-ol O-acetyltransferase | False | 2 | 38 | 0 | 4 | acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate | acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase | None | acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase | |
| 2.3.1.163 | 10-hydroxytaxane O-acetyltransferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C | acetyl-CoA:taxan-10beta-ol O-acetyltransferase | None | acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase | |
| 2.3.1.164 | isopenicillin-N N-acyltransferase | False | 3 | 34 | 3 | 2 | phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate | acyl-CoA:isopenicillin N N-acyltransferase | None | acyl-coenzyme A:isopenicillin N acyltransferase; isopenicillin N:acyl-CoA: acyltransferase | |
| 2.3.1.165 | 6-methylsalicylic-acid synthase | False | 8 | 43 | 0 | 9 | acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing) | None | MSAS; 6-methylsalicylic acid synthase | |
| 2.3.1.166 | 2alpha-hydroxytaxane 2-O-benzoyltransferase | False | 1 | 1 | 0 | 4 | benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III | benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase | None | benzoyl-CoA:taxane 2alpha-O-benzoyltransferase | |
| 2.3.1.167 | 10-deacetylbaccatin III 10-O-acetyltransferase | False | 1 | 8 | 0 | 16 | acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III | acetyl-CoA:taxan-10beta-ol O-acetyltransferase | None | None | |
| 2.3.1.168 | dihydrolipoyllysine-residue (2-methylpropanoyl)transferase | False | 9 | 408 | 7 | 19 | 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine | 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase | None | dihydrolipoyl transacylase; enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase; 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase | |
| 2.3.1.169 | CO-methylating acetyl-CoA synthase | False | 12 | 3010 | 10 | 10 | acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] | acetyl-CoA:corrinoid protein O-acetyltransferase | None | None | |
| 2.3.1.247 | (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase | False | 3 | 454 | 0 | 3 | (5S)-5-amino-3-oxohexanoate + acetyl-CoA = acetoacetate + L-3-aminobutanoyl-CoA | (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase | None | kce (gene name); 3-keto-5-aminohexanoate cleavage enzyme | |
| 2.3.1.170 | 6'-deoxychalcone synthase | False | 1 | 19 | 0 | 1 | 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) | None | None | |
| 2.3.1.171 | anthocyanin 6''-O-malonyltransferase | False | 1 | 31 | 0 | 6 | malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) | malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase | None | None | |
| 2.3.1.172 | anthocyanin 5-O-glucoside 6'''-O-malonyltransferase | False | 1 | 5 | 0 | 2 | malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin | malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase | None | None | |
| 2.3.1.173 | flavonol-3-O-triglucoside O-coumaroyltransferase | True | 0 | 0 | 0 | 1 | 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] | 4-coumaroyl-CoA:flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase | None | 4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase (incorrect) | |
| 2.3.1.174 | 3-oxoadipyl-CoA thiolase | False | 7 | 10502 | 1 | 3 | succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA | succinyl-CoA:acetyl-CoA C-succinyltransferase | None | None | |
| 2.3.1.175 | deacetylcephalosporin-C acetyltransferase | False | 1 | 3 | 3 | 1 | acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C | acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase | None | acetyl-CoA:deacetylcephalosporin-C acetyltransferase; DAC acetyltransferase; cefG; deacetylcephalosporin C acetyltransferase; acetyl coenzyme A:DAC acetyltransferase; acetyl-CoA:DAC acetyltransferase; CPC acetylhydrolase; acetyl-CoA:DAC O-acetyltransferase; DAC-AT | |
| 2.3.1.176 | propanoyl-CoA C-acyltransferase | False | 7 | 8873 | 3 | 10 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase | None | SCP2 (gene name); peroxisomal thiolase 2; sterol carrier protein-chi; SCPchi; PTE-2 (ambiguous); propionyl-CoA C2-trimethyltridecanoyltransferase; 3-oxopristanoyl-CoA hydrolase; 3-oxopristanoyl-CoA thiolase; peroxisome sterol carrier protein thiolase; sterol carrier protein; oxopristanoyl-CoA thiolase; peroxisomal 3-oxoacyl coenzyme A thiolase; SCPx; 4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase | |
| 2.3.2.1 | D-glutamyltransferase | False | 0 | 6 | 0 | 2 | (1) D-glutamine + D-glutamate = NH3 + gamma-D-glutamyl-D-glutamate;;(2) L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = NH3 + (gamma-D-glutamyl)n+1-[peptide] | glutamine:D-glutamyl-peptide 5-glutamyltransferase | None | D-glutamyl transpeptidase; D-gamma-glutamyl transpeptidase | |
| 2.3.2.2 | gamma-glutamyltransferase | False | 33 | 38024 | 33 | 51 | a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase | None | glutamyl transpeptidase; alpha-glutamyl transpeptidase; gamma-glutamyl peptidyltransferase; gamma-glutamyl transpeptidase (ambiguous); gamma-GPT; gamma-GT; gamma-GTP; L-gamma-glutamyl transpeptidase; L-gamma-glutamyltransferase; L-glutamyltransferase; GGT (ambiguous); gamma-glutamyltranspeptidase (ambiguous) | |
| 2.3.2.3 | lysyltransferase | False | 39 | 7666 | 1 | 6 | L-lysyl-tRNALys + phosphatidylglycerol = tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol | L-lysyl-tRNALys:phosphatidylglycerol 3-O-lysyltransferase | None | L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase | |
| 2.3.2.5 | glutaminyl-peptide cyclotransferase | False | 17 | 2899 | 67 | 24 | L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3 | L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing) | None | glutaminyl-tRNA cyclotransferase; glutaminyl cyclase; glutaminyl-transfer ribonucleate cyclotransferase | |
| 2.3.2.6 | lysine/arginine leucyltransferase | False | 305 | 19603 | 9 | 1 | (1) L-leucyl-tRNALeu + N-terminal L-lysyl-[protein] = tRNALeu + N-terminal L-leucyl-L-lysyl-[protein] ;;(2) L-leucyl-tRNALeu + N-terminal L-arginyl-[protein] = tRNALeu + N-terminal L-leucyl-L-arginyl-[protein] | L-leucyl-tRNALeu:[protein] N-terminal L-lysine/L-arginine leucyltransferase | None | leucyl, phenylalanine-tRNA-protein transferase; leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase; leucyl-phenylalanine-transfer ribonucleate-protein transferase; L-leucyl-tRNA:protein leucyltransferase; leucyltransferase (misleading); L/FK,R-transferase; aat (gene name); L-leucyl-tRNALeu:protein leucyltransferase | |
| 2.3.2.7 | aspartyltransferase | True | 0 | 0 | 0 | 2 | L-asparagine + hydroxylamine = NH3 + beta-L-aspartylhydroxamate | L-asparagine:hydroxylamine gamma-aspartyltransferase | None | beta-aspartyl transferase; aspartotransferase | |
| 2.3.2.8 | arginyltransferase | False | 9 | 5039 | 7 | 15 | L-arginyl-tRNAArg + protein = tRNAArg + L-arginyl-[protein] | L-arginyl-tRNAArg:protein arginyltransferase | None | arginine transferase; arginyl-transfer ribonucleate-protein aminoacyltransferase; arginyl-transfer ribonucleate-protein transferase; arginyl-tRNA protein transferase; L-arginyl-tRNA:protein arginyltransferase | |
| 2.3.2.9 | agaritine gamma-glutamyltransferase | True | 0 | 0 | 0 | 6 | agaritine + acceptor = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor | (gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:acceptor gamma-glutamyltransferase | None | (gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase; (gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase; (gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:acceptor gamma-glutamyltransferase | |
| 2.3.2.10 | UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase | False | 1 | 72 | 10 | 1 | L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine = tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine | L-alanyl-tRNAAla:UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase | None | alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase; UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase; uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase | |
| 2.3.2.11 | alanylphosphatidylglycerol synthase | False | 0 | 4 | 2 | 4 | L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol | L-alanyl-tRNAAla:phosphatidylglycerol alanyltransferase | None | O-alanylphosphatidylglycerol synthase; alanyl phosphatidylglycerol synthetase | |
| 2.3.2.12 | peptidyltransferase | False | 0 | 6 | 9 | 15 | peptidyl-tRNA1 + aminoacyl-tRNA2 = tRNA1 + peptidyl(aminoacyl-tRNA2) | peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase | None | transpeptidase; ribosomal peptidyltransferase | |
| 2.3.2.13 | protein-glutamine gamma-glutamyltransferase | False | 51 | 4499 | 41 | 56 | protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | protein-glutamine:amine gamma-glutamyltransferase | None | transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide gamma-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine gamma-glutamyl transferase | |
| 2.3.2.14 | D-alanine gamma-glutamyltransferase | True | 0 | 0 | 0 | 1 | L-glutamine + D-alanine = NH3 + gamma-L-glutamyl-D-alanine | L-glutamine:D-alanine gamma-glutamyltransferase | None | None | |
| 2.3.2.15 | glutathione gamma-glutamylcysteinyltransferase | False | 8 | 3177 | 2 | 36 | glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly | glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase | None | phytochelatin synthase; gamma-glutamylcysteine dipeptidyl transpeptidase | |
| 2.3.3.1 | citrate (Si)-synthase | False | 21 | 1280 | 24 | 12 | acetyl-CoA + H2O + oxaloacetate = citrate + CoA | acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl-forming] | None | (R)-citric synthase; citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetyl-CoA] | |
| 2.3.3.16 | citrate synthase (unknown stereospecificity) | False | 105 | 24359 | 19 | 92 | acetyl-CoA + H2O + oxaloacetate = citrate + CoA | acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) | None | citrate condensing enzyme; CoA-acetylating citrate oxaloacetate-lyase; citrate synthetase; citric synthase; citric-condensing enzyme; citrogenase; condensing enzyme (ambiguous); oxaloacetate transacetase; oxalacetic transacetase | |
| 2.3.3.2 | decylcitrate synthase | True | 0 | 0 | 0 | 1 | lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA | dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming) | None | 2-decylcitrate synthase; (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating) | |
| 2.3.3.3 | citrate (Re)-synthase | False | 3 | 39 | 0 | 8 | acetyl-CoA + H2O + oxaloacetate = citrate + CoA | acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming] | None | (R)-citrate synthase; Re-citrate-synthase; citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA] | |
| 2.3.3.4 | decylhomocitrate synthase | True | 0 | 0 | 0 | 1 | dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA | dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming) | None | 2-decylhomocitrate synthase; 3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating) | |
| 2.3.3.5 | 2-methylcitrate synthase | False | 15 | 362 | 11 | 56 | propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA | propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) | None | 2-methylcitrate oxaloacetate-lyase; MCS; methylcitrate synthase; methylcitrate synthetase | |
| 2.3.3.6 | 2-ethylmalate synthase | True | 0 | 0 | 0 | 2 | acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA | acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | None | (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating); 2-ethylmalate-3-hydroxybutanedioate synthase; propylmalate synthase; propylmalic synthase | |
| 2.3.3.7 | 3-ethylmalate synthase | True | 0 | 0 | 0 | 2 | butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA | butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming) | None | 2-ethyl-3-hydroxybutanedioate synthase; 3-ethylmalate glyoxylate-lyase (CoA-butanoylating) | |
| 2.3.3.8 | ATP citrate synthase | False | 20 | 7419 | 36 | 48 | ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA | acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating] | None | ATP-citric lyase; ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating); acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating); adenosine triphosphate citrate lyase; citrate cleavage enzyme; citrate-ATP lyase; citric cleavage enzyme; ATP citrate (pro-S)-lyase | |
| 2.3.3.9 | malate synthase | False | 109 | 26004 | 65 | 51 | acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA | acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming] | None | L-malate glyoxylate-lyase (CoA-acetylating); glyoxylate transacetylase; glyoxylate transacetase; glyoxylic transacetase; malate condensing enzyme; malate synthetase; malic synthetase; malic-condensing enzyme; acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | |
| 2.3.3.10 | hydroxymethylglutaryl-CoA synthase | False | 29 | 7577 | 18 | 61 | acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | None | (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating); 3-hydroxy-3-methylglutaryl CoA synthetase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthetase; 3-hydroxy-3-methylglutaryl-CoA synthase; 3-hydroxy-3-methylglutaryl-coenzyme A synthase; beta-hydroxy-beta-methylglutaryl-CoA synthase; HMG-CoA synthase; acetoacetyl coenzyme A transacetase; hydroxymethylglutaryl coenzyme A synthase; hydroxymethylglutaryl coenzyme A-condensing enzyme | |
| 2.3.3.11 | 2-hydroxyglutarate synthase | True | 0 | 0 | 0 | 1 | propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA | propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming) | None | 2-hydroxyglutaratic synthetase; 2-hydroxyglutaric synthetase; alpha-hydroxyglutarate synthase; hydroxyglutarate synthase; 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) | |
| 2.3.3.12 | 3-propylmalate synthase | True | 0 | 0 | 0 | 1 | pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA | pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming) | None | 3-(n-propyl)-malate synthase; 3-propylmalate glyoxylate-lyase (CoA-pentanoylating); beta-n-propylmalate synthase; n-propylmalate synthase | |
| 2.3.3.13 | 2-isopropylmalate synthase | False | 418 | 45200 | 15 | 44 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA | acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | None | 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); alpha-isopropylmalate synthetase; alpha-isopropylmalate synthase; alpha-isopropylmalic synthetase; isopropylmalate synthase; isopropylmalate synthetase | |
| 2.3.3.14 | homocitrate synthase | False | 35 | 5354 | 9 | 18 | acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | None | 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating); acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase; homocitrate synthetase; HCS | |
| 2.3.3.15 | sulfoacetaldehyde acetyltransferase | False | 6 | 2431 | 0 | 8 | acetyl phosphate + sulfite = 2-sulfoacetaldehyde + phosphate | acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming) | None | Xsc | |
| 2.4.1.1 | glycogen phosphorylase | False | 48 | 38984 | 268 | 70 | [(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase | None | muscle phosphorylase a and b; amylophosphorylase; polyphosphorylase; amylopectin phosphorylase; glucan phosphorylase; alpha-glucan phosphorylase; 1,4-alpha-glucan phosphorylase; glucosan phosphorylase; granulose phosphorylase; maltodextrin phosphorylase; muscle phosphorylase; myophosphorylase; potato phosphorylase; starch phosphorylase; 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase; phosphorylase (ambiguous) | |
| 2.4.1.2 | dextrin dextranase | False | 0 | 9 | 0 | 1 | [(1->4)-alpha-D-glucosyl]n + [(1->6)-alpha-D-glucosyl]m = [(1->4)-alpha-D-glucosyl]n-1 + [(1->6)-alpha-D-glucosyl]m+1 | (1->4)-alpha-D-glucan:(1->6)-alpha-D-glucan 6-alpha-D-glucosyltransferase | None | dextrin 6-glucosyltransferase; dextran dextrinase; 1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase | |
| 2.4.1.4 | amylosucrase | False | 2 | 372 | 21 | 22 | sucrose + [(1->4)-alpha-D-glucosyl]n = D-fructose + [(1->4)-alpha-D-glucosyl]n+1 | sucrose:(1->4)-alpha-D-glucan 4-alpha-D-glucosyltransferase | None | sucrose---glucan glucosyltransferase; sucrose-1,4-alpha-glucan glucosyltransferase; sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase | |
| 2.4.1.5 | dextransucrase | False | 10 | 752 | 32 | 18 | sucrose + [(1->6)-alpha-D-glucosyl]n = D-fructose + [(1->6)-alpha-D-glucosyl]n+1 | sucrose:(1->6)-alpha-D-glucan 6-alpha-D-glucosyltransferase | None | sucrose 6-glucosyltransferase; SGE; CEP; sucrose-1,6-alpha-glucan glucosyltransferase; sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase | |
| 2.4.1.7 | sucrose phosphorylase | False | 4 | 1969 | 10 | 11 | sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate | sucrose:phosphate alpha-D-glucosyltransferase | None | sucrose glucosyltransferase; disaccharide glucosyltransferase | |
| 2.4.1.8 | maltose phosphorylase | False | 2 | 437 | 1 | 14 | maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate | maltose:phosphate 1-beta-D-glucosyltransferase | None | None | |
| 2.4.1.9 | inulosucrase | False | 2 | 14 | 3 | 20 | sucrose + [(2->1)-beta-D-fructosyl]n = glucose + [(2->1)-beta-D-fructosyl]n+1 | sucrose:(2->1)-beta-D-fructan 1-beta-D-fructosyltransferase | None | sucrose 1-fructosyltransferase; sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase | |
| 2.4.1.10 | levansucrase | False | 17 | 816 | 23 | 55 | sucrose + [6)-beta-D-fructofuranosyl-(2->]n alpha-D-glucopyranoside = D-glucose + [6)-beta-D-fructofuranosyl-(2->]n+1 alpha-D-glucopyranoside | sucrose:[6)-beta-D-fructofuranosyl-(2->]n alpha-D-glucopyranoside 6-beta-D-fructosyltransferase | None | sucrose 6-fructosyltransferase; beta-2,6-fructosyltransferase; beta-2,6-fructan:D-glucose 1-fructosyltransferase; sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase; sucrose:(2->6)-beta-D-fructan 6-beta-D-fructosyltransferase | |
| 2.4.1.11 | glycogen(starch) synthase | False | 18 | 6681 | 23 | 30 | UDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1 | UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase (configuration-retaining) | None | UDP-glucose---glycogen glucosyltransferase; glycogen (starch) synthetase; UDP-glucose-glycogen glucosyltransferase; UDP-glycogen synthase; UDPG-glycogen synthetase; UDPG-glycogen transglucosylase; uridine diphosphoglucose-glycogen glucosyltransferase; UDP-glucose:glycogen 4-alpha-D-glucosyltransferase | |
| 2.4.1.12 | cellulose synthase (UDP-forming) | False | 40 | 16930 | 14 | 39 | UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n = UDP + [(1->4)-beta-D-glucosyl]n+1 | UDP-alpha-D-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase (configuration-inverting) | None | UDP-glucose---beta-glucan glucosyltransferase; UDP-glucose-cellulose glucosyltransferase; GS-I; beta-1,4-glucosyltransferase; uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase; beta-1,4-glucan synthase; beta-1,4-glucan synthetase; beta-glucan synthase; 1,4-beta-D-glucan synthase; 1,4-beta-glucan synthase; glucan synthase; UDP-glucose-1,4-beta-glucan glucosyltransferase; uridine diphosphoglucose-cellulose glucosyltransferase; UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase; UDP-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase | |
| 2.4.1.13 | sucrose synthase | False | 37 | 4952 | 4 | 62 | NDP-alpha-D-glucose + D-fructose = NDP + sucrose | NDP-alpha-D-glucose:D-fructose 2-alpha-D-glucosyltransferase (configuration-retaining) | None | UDPglucose-fructose glucosyltransferase; sucrose synthetase; sucrose-UDP glucosyltransferase; sucrose-uridine diphosphate glucosyltransferase; uridine diphosphoglucose-fructose glucosyltransferase; NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase | |
| 2.4.1.14 | sucrose-phosphate synthase | False | 19 | 2419 | 3 | 60 | UDP-alpha-D-glucose + D-fructose 6-phosphate = UDP + sucrose 6F-phosphate | UDP-alpha-D-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase (configuration-retaining) | None | UDP-glucose---fructose-phosphate glucosyltransferase; sucrosephosphate---UDP glucosyltransferase; UDP-glucose-fructose-phosphate glucosyltransferase; SPS; uridine diphosphoglucose-fructose phosphate glucosyltransferase; sucrose 6-phosphate synthase; sucrose phosphate synthetase; sucrose phosphate-uridine diphosphate glucosyltransferase; sucrose phosphate synthase; UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase | |
| 2.4.1.15 | alpha,alpha-trehalose-phosphate synthase (UDP-forming) | False | 78 | 8006 | 24 | 49 | UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate | UDP-alpha-D-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase (configuration-retaining) | None | UDP-glucose---glucose-phosphate glucosyltransferase; trehalosephosphate-UDP glucosyltransferase; UDP-glucose-glucose-phosphate glucosyltransferase; alpha,alpha-trehalose phosphate synthase (UDP-forming); phosphotrehalose-uridine diphosphate transglucosylase; trehalose 6-phosphate synthase; trehalose 6-phosphate synthetase; trehalose phosphate synthase; trehalose phosphate synthetase; trehalose phosphate-uridine diphosphate glucosyltransferase; trehalose-P synthetase; transglucosylase; uridine diphosphoglucose phosphate glucosyltransferase; UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | |
| 2.4.1.16 | chitin synthase | False | 68 | 19247 | 20 | 79 | UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n = UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1 | UDP-N-acetyl-alpha-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase (configuration-inverting) | None | chitin-UDP N-acetylglucosaminyltransferase; chitin-uridine diphosphate acetylglucosaminyltransferase; chitin synthetase; trans-N-acetylglucosaminosylase; UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase; UDP-N-acetyl-alpha-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase | |
| 2.4.1.17 | glucuronosyltransferase | False | 75 | 13698 | 9 | 27 | UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside | UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; configuration-inverting) | None | 1-naphthol glucuronyltransferase; 1-naphthol-UDP-glucuronosyltransferase; 17beta-hydroxysteroid UDP-glucuronosyltransferase; 3alpha-hydroxysteroid UDP-glucuronosyltransferase; 4-hydroxybiphenyl UDP-glucuronosyltransferase; 4-methylumbelliferone UDP-glucuronosyltransferase; 4-nitrophenol UDP-glucuronyltransferase; 4-nitrophenol UDPGT; 17-OH steroid UDPGT; 3-OH androgenic UDPGT; bilirubin uridine diphosphoglucuronyltransferase; bilirubin UDP-glucuronosyltransferase; bilirubin monoglucuronide glucuronyltransferase; bilirubin UDPGT; bilirubin glucuronyltransferase; ciramadol UDP-glucuronyltransferase; estriol UDP-glucuronosyltransferase; estrone UDP-glucuronosyltransferase; uridine diphosphoglucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronosyltransferase; uridine diphosphoglucuronate-estriol glucuronosyltransferase; uridine diphosphoglucuronate-estradiol glucuronosyltransferase; uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase; uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase; uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase; GT; morphine glucuronyltransferase; p-hydroxybiphenyl UDP glucuronyltransferase; p-nitrophenol UDP-glucuronosyltransferase; p-nitrophenol UDP-glucuronyltransferase; p-nitrophenylglucuronosyltransferase; p-phenylphenol glucuronyltransferase; phenyl-UDP-glucuronosyltransferase; PNP-UDPGT; UDP glucuronate-estradiol-glucuronosyltransferase; UDP glucuronosyltransferase; UDP glucuronate-estriol glucuronosyltransferase; UDP glucuronic acid transferase; UDP glucuronyltransferase; UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase; UDP-glucuronate-bilirubin glucuronyltransferase; UDP-glucuronosyltransferase; UDP-glucuronyltransferase; UDPGA transferase; UDPGA-glucuronyltransferase; UDPGT; uridine diphosphoglucuronyltransferase; uridine diphosphate glucuronyltransferase; uridine 5'-diphosphoglucuronyltransferase; UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) | |
| 2.4.1.18 | 1,4-alpha-glucan branching enzyme | False | 296 | 34511 | 35 | 56 | Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain | (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 6-alpha-D-[(1->4)-alpha-D-glucano]-transferase | None | branching enzyme; amylo-(1,4->1,6)-transglycosylase; Q-enzyme; alpha-glucan-branching glycosyltransferase; amylose isomerase; enzymatic branching factor; branching glycosyltransferase; enzyme Q; glucosan transglycosylase; glycogen branching enzyme; plant branching enzyme; alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase; starch branching enzyme; 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase | |
| 2.4.1.19 | cyclomaltodextrin glucanotransferase | False | 16 | 161 | 55 | 54 | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond | (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 4-alpha-D-[(1->4)-alpha-D-glucano]-transferase (cyclizing) | None | Bacillus macerans amylase; cyclodextrin glucanotransferase; alpha-cyclodextrin glucanotransferase; alpha-cyclodextrin glycosyltransferase; beta-cyclodextrin glucanotransferase; beta-cyclodextrin glycosyltransferase; gamma-cyclodextrin glycosyltransferase; cyclodextrin glycosyltransferase; cyclomaltodextrin glucotransferase; cyclomaltodextrin glycosyltransferase; konchizaimu; alpha-1,4-glucan 4-glycosyltransferase, cyclizing; BMA; CGTase; neutral-cyclodextrin glycosyltransferase; 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing) | |
| 2.4.1.20 | cellobiose phosphorylase | False | 1 | 148 | 23 | 15 | cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose | cellobiose:phosphate alpha-D-glucosyltransferase | None | None | |
| 2.4.1.21 | starch synthase (glycosyl-transferring) | False | 351 | 32578 | 16 | 40 | ADP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = ADP + [(1->4)-alpha-D-glucosyl]n+1 | ADP-alpha-D-glucose:(1->4)-alpha-D-glucan 4-alpha-D-glucosyltransferase | None | ADP-glucose---starch glucosyltransferase; adenosine diphosphate glucose-starch glucosyltransferase; adenosine diphosphoglucose-starch glucosyltransferase; ADP-glucose starch synthase; ADP-glucose transglucosylase; ADP-glucose-starch glucosyltransferase; ADPG starch synthetase; ADPG-starch glucosyltransferase; starch synthetase; ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase | |
| 2.4.1.22 | lactose synthase | False | 7 | 18 | 20 | 20 | UDP-alpha-D-galactose + D-glucose = UDP + lactose | UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase | None | UDP-galactose---glucose galactosyltransferase; N-acetyllactosamine synthase; uridine diphosphogalactose-glucose galactosyltransferase; lactose synthetase; UDP-galactose:D-glucose 4-beta-D-galactotransferase; UDP-galactose:D-glucose 4-beta-D-galactosyltransferase | |
| 2.4.1.23 | sphingosine beta-galactosyltransferase | True | 0 | 0 | 0 | 3 | UDP-alpha-D-galactose + sphingosine = UDP + psychosine | UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase | None | psychosine---UDP galactosyltransferase; galactosyl-sphingosine transferase; psychosine-uridine diphosphate galactosyltransferase; UDP-galactose:sphingosine O-galactosyl transferase; uridine diphosphogalactose-sphingosine beta-galactosyltransferase; UDP-galactose:sphingosine 1-beta-galactotransferase; UDP-galactose:sphingosine 1-beta-galactosyltransferase | |
| 2.4.1.24 | 1,4-alpha-glucan 6-alpha-glucosyltransferase | False | 1 | 0 | 0 | 2 | Transfers an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan | (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase | None | oligoglucan-branching glycosyltransferase; 1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase; T-enzyme; D-glucosyltransferase; 1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase | |
| 2.4.1.25 | 4-alpha-glucanotransferase | False | 29 | 30017 | 36 | 60 | Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan | (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 4-alpha-D-glycosyltransferase | None | disproportionating enzyme; dextrin glycosyltransferase; D-enzyme; debranching enzyme maltodextrin glycosyltransferase; amylomaltase; dextrin transglycosylase; 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase | |
| 2.4.1.26 | DNA alpha-glucosyltransferase | False | 1 | 8 | 5 | 2 | Transfers an alpha-D-glucosyl residue from UDP-glucose to an hydroxymethylcytosine residue in DNA | UDP-glucose:DNA alpha-D-glucosyltransferase | None | uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase; UDP-glucose-DNA alpha-glucosyltransferase; uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase; T2-HMC-alpha-glucosyl transferase; T4-HMC-alpha-glucosyl transferase; T6-HMC-alpha-glucosyl transferase | |
| 2.4.1.27 | DNA beta-glucosyltransferase | False | 1 | 2 | 20 | 1 | Transfers a beta-D-glucosyl residue from UDP-alpha-D-glucose to an hydroxymethylcytosine residue in DNA | UDP-alpha-D-glucose:DNA beta-D-glucosyltransferase (configuration-inverting) | None | T4-HMC-beta-glucosyl transferase; T4-beta-glucosyl transferase; T4 phage beta-glucosyltransferase; UDP glucose-DNA beta-glucosyltransferase; uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase; UDP-glucose:DNA beta-D-glucosyltransferase | |
| 2.4.1.28 | glucosyl-DNA beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | Transfers a beta-D-glucosyl residue from UDP-alpha-D-glucose to a glucosylhydroxymethylcytosine residue in DNA | UDP-alpha-D-glucose:D-glucosyl-DNA beta-D-glucosyltransferase (configuration-inverting) | None | T6-glucosyl-HMC-beta-glucosyl transferase; T6-beta-glucosyl transferase; uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase | |
| 2.4.1.29 | cellulose synthase (GDP-forming) | True | 0 | 0 | 0 | 2 | GDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n = GDP + [(1->4)-beta-D-glucosyl]n+1 | GDP-alpha-D-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase (configuration-inverting) | None | cellulose synthase (guanosine diphosphate-forming); cellulose synthetase; guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase; guanosine diphosphoglucose-cellulose glucosyltransferase; GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase | |
| 2.4.1.30 | 1,3-beta-oligoglucan phosphorylase | False | 0 | 2 | 0 | 3 | [(1->3)-beta-D-glucosyl]n + phosphate = [(1->3)-beta-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | (1->3)-beta-D-glucan:phosphate alpha-D-glucosyltransferase | None | beta-1,3-oligoglucan:orthophosphate glucosyltransferase II; beta-1,3-oligoglucan phosphorylase; 1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase | |
| 2.4.1.31 | laminaribiose phosphorylase | False | 0 | 2 | 3 | 5 | 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate | 3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase | None | None | |
| 2.4.1.32 | glucomannan 4-beta-mannosyltransferase | False | 19 | 122 | 0 | 6 | GDP-mannose + (glucomannan)n = GDP + (glucomannan)n+1 | GDP-mannose:glucomannan 4-beta-D-mannosyltransferase | None | GDP-man-beta-mannan manosyltransferase; glucomannan-synthase; GDPmannose:glucomannan 1,4-beta-D-mannosyltransferase; GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase | |
| 2.4.1.33 | mannuronan synthase | False | 2 | 130 | 0 | 2 | GDP-alpha-D-mannuronate + [(1->4)-beta-D-mannuronosyl]n = GDP + [(1->4)-beta-D-mannuronosyl]n+1 | GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase | None | mannuronosyl transferase; alginate synthase (incorrect); alg8 (gene name); alg44 (gene name); GDP-D-mannuronate:alginate D-mannuronyltransferase | |
| 2.4.1.34 | 1,3-beta-glucan synthase | False | 22 | 6949 | 3 | 50 | UDP-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1 | UDP-glucose:(1->3)-beta-D-glucan 3-beta-D-glucosyltransferase | None | 1,3-beta-D-glucan---UDP glucosyltransferase; UDP-glucose---1,3-beta-D-glucan glucosyltransferase; callose synthetase; 1,3-beta-D-glucan-UDP glucosyltransferase; UDP-glucose-1,3-beta-D-glucan glucosyltransferase; paramylon synthetase; UDP-glucose-beta-glucan glucosyltransferase; GS-II; (1,3)-beta-glucan (callose) synthase; beta-1,3-glucan synthase; beta-1,3-glucan synthetase; 1,3-beta-D-glucan synthetase; 1,3-beta-D-glucan synthase; 1,3-beta-glucan-uridine diphosphoglucosyltransferase; callose synthase; UDP-glucose-1,3-beta-glucan glucosyltransferase; UDP-glucose:(1,3)beta-glucan synthase; uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase; UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase | |
| 2.4.1.35 | phenol beta-glucosyltransferase | False | 0 | 2 | 0 | 23 | UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside | UDP-glucose:phenol beta-D-glucosyltransferase | None | UDPglucosyltransferase (ambiguous); phenol-beta-D-glucosyltransferase; UDP glucosyltransferase (ambiguous); UDP-glucose glucosyltransferase (ambiguous); uridine diphosphoglucosyltransferase | |
| 2.4.1.36 | alpha,alpha-trehalose-phosphate synthase (GDP-forming) | False | 0 | 6 | 1 | 5 | GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate | GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | None | GDP-glucose---glucose-phosphate glucosyltransferase; guanosine diphosphoglucose-glucose phosphate glucosyltransferase; trehalose phosphate synthase (GDP-forming) | |
| 2.4.1.37 | fucosylgalactoside 3-alpha-galactosyltransferase | False | 5 | 78 | 49 | 9 | UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) | UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase | None | UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase; UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase; [blood group substance] alpha-galactosyltransferase; blood-group substance B-dependent galactosyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group B transferase; histo-blood substance B-dependent galactosyltransferase; UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase; UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase | |
| 2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase | False | 13 | 156 | 4 | 16 | UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide | UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase | None | UDP-galactose---glycoprotein galactosyltransferase; glycoprotein 4-beta-galactosyl-transferase; beta-N-acetyl-beta1-4-galactosyltransferase; thyroid glycoprotein beta-galactosyltransferase; glycoprotein beta-galactosyltransferase; thyroid galactosyltransferase; uridine diphosphogalactose-glycoprotein galactosyltransferase; beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase; GalT; UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase; UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase | |
| 2.4.1.39 | steroid N-acetylglucosaminyltransferase | True | 0 | 0 | 0 | 1 | UDP-N-acetyl-alpha-D-glucosamine + estradiol-17alpha 3-D-glucuronoside = UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside | UDP-N-acetyl-alpha-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase | None | hydroxy steroid acetylglucosaminyltransferase; steroid acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase | |
| 2.4.1.40 | glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase | False | 4 | 29 | 83 | 9 | UDP-N-acetyl-alpha-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose | UDP-N-acetyl-alpha-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase | None | A-transferase; histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase); UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase; alpha-3-N-acetylgalactosaminyltransferase; blood-group substance alpha-acetyltransferase; blood-group substance A-dependent acetylgalactosaminyltransferase; fucosylgalactose acetylgalactosaminyltransferase; histo-blood group A acetylgalactosaminyltransferase; histo-blood group A transferase; UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase | |
| 2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase | False | 67 | 658 | 27 | 20 | (1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine;;(2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine | UDP-N-alpha-acetyl-D-galactosamine:[protein]-3-O-N-acetyl-alpha-D-galactosaminyl transferase (configuration-retaining) | None | protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acetylgalactosaminyltransferase; polypeptide-N-acetylgalactosamine transferase; UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase; ppGalNAc-T; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase | |
| 2.4.1.43 | polygalacturonate 4-alpha-galacturonosyltransferase | False | 2 | 38 | 0 | 8 | UDP-alpha-D-galacturonate + [(1->4)-alpha-D-galacturonosyl]n = UDP + [(1->4)-alpha-D-galacturonosyl]n+1 | UDP-alpha-D-galacturonate:(1->4)-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase (configuration-retaining) | None | UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase; uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase; UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase; UDP-D-galacturonate:(1->4)-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase | |
| 2.4.1.44 | lipopolysaccharide 3-alpha-galactosyltransferase | False | 1 | 1499 | 2 | 3 | UDP-alpha-D-galactose + lipopolysaccharide = UDP + 3-alpha-D-galactosyl-[lipopolysaccharide glucose] | UDP-alpha-D-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase | None | UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase; UDP-galactose:polysaccharide galactosyltransferase; uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase; uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase; UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase | |
| 2.4.1.46 | monogalactosyldiacylglycerol synthase | False | 11 | 1274 | 2 | 13 | UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol | UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase | None | uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase; UDP-galactose:diacylglycerol galactosyltransferase; MGDG synthase; UDP galactose-1,2-diacylglycerol galactosyltransferase; UDP-galactose-diacylglyceride galactosyltransferase; UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase; 1beta-MGDG; 1,2-diacylglycerol 3-beta-galactosyltransferase; UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase | |
| 2.4.1.47 | N-acylsphingosine galactosyltransferase | False | 3 | 9 | 0 | 8 | UDP-alpha-D-galactose + a ceramide = UDP + a beta-D-galactosylceramide | UDP-alpha-D-galactose:N-acylsphingosine beta-D-galactosyltransferase (configuration-inverting) | None | UGT8 (gene name); CGT (gene name); UDP galactose-N-acylsphingosine galactosyltransferase; uridine diphosphogalactose-acylsphingosine galactosyltransferase; UDP-galactose:N-acylsphingosine D-galactosyltransferase; UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | |
| 2.4.1.48 | heteroglycan alpha-mannosyltransferase | True | 0 | 0 | 0 | 2 | GDP-mannose + heteroglycan = GDP + 2(or 3)-alpha-D-mannosyl-heteroglycan | GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase | None | GDP mannose alpha-mannosyltransferase; guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase | |
| 2.4.1.49 | cellodextrin phosphorylase | False | 0 | 13 | 0 | 5 | [(1->4)-beta-D-glucosyl]n + phosphate = [(1->4)-beta-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | (1->4)-beta-D-glucan:phosphate alpha-D-glucosyltransferase | None | beta-1,4-oligoglucan:orthophosphate glucosyltransferase; 1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase | |
| 2.4.1.50 | procollagen galactosyltransferase | False | 13 | 969 | 0 | 5 | UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine | UDP-alpha-D-galactose:[procollagen]-(5R)-5-hydroxy-L-lysine 5-beta-D-galactosyltransferase (configuration-inverting) | None | hydroxylysine galactosyltransferase; collagen galactosyltransferase; collagen hydroxylysyl galactosyltransferase; UDP galactose-collagen galactosyltransferase; uridine diphosphogalactose-collagen galactosyltransferase; UDPgalactose:5-hydroxylysine-collagen galactosyltransferase; UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase; UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase | |
| 2.4.1.52 | poly(glycerol-phosphate) alpha-glucosyltransferase | False | 1 | 835 | 0 | 1 | n UDP-alpha-D-glucose + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-D-glucosyltransferase (configuration-retaining) | None | UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase; uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase; tagE (gene name); UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase | |
| 2.4.1.53 | poly(ribitol-phosphate) beta-glucosyltransferase | False | 1 | 6 | 0 | 1 | n UDP-alpha-D-glucose + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-[(2-beta-D-glucosyl-1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-glucose:4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-D-glucosyltransferase (configuration-inverting) | None | TarQ; UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase; uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase; UDP-D-glucose polyribitol phosphate glucosyl transferase; UDP-D-glucose:polyribitol phosphate glucosyl transferase; UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase | |
| 2.4.1.54 | undecaprenyl-phosphate mannosyltransferase | False | 1 | 1339 | 0 | 4 | GDP-alpha-D-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol | GDP-alpha-D-mannose:undecaprenyl-phosphate D-mannosyltransferase | None | guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase; GDP mannose-undecaprenyl phosphate mannosyltransferase; GDP-D-mannose:lipid phosphate transmannosylase; GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase | |
| 2.4.1.56 | lipopolysaccharide N-acetylglucosaminyltransferase | False | 1 | 1034 | 0 | 4 | UDP-N-acetyl-alpha-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-alpha-D-glucosaminyllipopolysaccharide | UDP-N-acetyl-alpha-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase | None | UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.58 | lipopolysaccharide glucosyltransferase I | False | 3 | 1305 | 0 | 5 | UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide | UDP-glucose:lipopolysaccharide glucosyltransferase | None | UDP-glucose:lipopolysaccharide glucosyltransferase I; lipopolysaccharide glucosyltransferase; uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I; uridine diphosphoglucose-lipopolysaccharide glucosyltransferase | |
| 2.4.1.60 | CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase | False | 1 | 50 | 0 | 1 | CDP-alpha-D-abequose + alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = CDP + alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und | CDP-alpha-D-abequose:alpha-D-mannopyranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3III-alpha-abequosyltransferase (configuration retaining) | None | wbaV (gene name); rfbV (gene name); trihexose diphospholipid abequosyltransferase; abequosyltransferase (ambiguous); CDP-alpha-D-abequose:Man(alpha1->4)Rha(alpha1->3)Gal(beta-1)-diphospholipid D-abequosyltransferase | |
| 2.4.1.62 | ganglioside galactosyltransferase | False | 5 | 3 | 0 | 10 | UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase | None | UDP-galactose---ceramide galactosyltransferase; uridine diphosphogalactose-ceramide galactosyltransferase; UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase; UDP-galactose-GM2 galactosyltransferase; uridine diphosphogalactose-GM2 galactosyltransferase; uridine diphosphate D-galactose:glycolipid galactosyltransferase; UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase; UDP-galactose-GM2 ganglioside galactosyltransferase; GM1-synthase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase | |
| 2.4.1.63 | linamarin synthase | False | 2 | 0 | 0 | 1 | UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin | UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase | None | uridine diphosphoglucose-ketone glucosyltransferase; uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase; UDP glucose ketone cyanohydrin glucosyltransferase; UDP-glucose:ketone cyanohydrin beta-glucosyltransferase; uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase | |
| 2.4.1.64 | alpha,alpha-trehalose phosphorylase | False | 2 | 433 | 0 | 16 | alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate | alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase | None | trehalose phosphorylase | |
| 2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase | False | 11 | 10 | 0 | 14 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R | GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase (configuration-inverting) | None | (Lea)-dependent (alpha-3/4)-fucosyltransferase; alpha(1,3/1,4) fucosyltransferase III; alpha-(1->4)-L-fucosyltransferase; alpha-4-L-fucosyltransferase; beta-acetylglucosaminylsaccharide fucosyltransferase; FucT-II; Lewis alpha-(1->3/4)-fucosyltransferase; Lewis blood group alpha-(1->3/4)-fucosyltransferase; Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase; blood-group substance Lea-dependent fucosyltransferase; guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase; guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase; guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase; 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase; GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase; GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase | |
| 2.4.1.66 | procollagen glucosyltransferase | False | 5 | 2 | 0 | 8 | UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine | UDP-alpha-D-glucose:[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine 2-alpha-D-glucosyltransferase (configuration-retaining) | None | galactosylhydroxylysine glucosyltransferase; collagen glucosyltransferase; collagen hydroxylysyl glucosyltransferase; galactosylhydroxylysyl glucosyltransferase; UDP-glucose-collagenglucosyltransferase; uridine diphosphoglucose-collagen glucosyltransferase; UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase; UDP-glucose:(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] D-glucosyltransferase | |
| 2.4.1.67 | galactinol---raffinose galactosyltransferase | False | 1 | 22 | 0 | 12 | alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose | alpha-D-galactosyl-(1->3)-1D-myo-inositol:raffinose galactosyltransferase | None | galactinol-raffinose galactosyltransferase; stachyose synthetase; alpha-D-galactosyl-(1->3)-myo-inositol:raffinose galactosyltransferase | |
| 2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase | False | 11 | 1047 | 11 | 16 | GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] | GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 6-alpha-L-fucosyltransferase (configuration-inverting) | None | GDP-fucose---glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase; GDP-L-fucose-glycoprotein fucosyltransferase; glycoprotein fucosyltransferase; guanosine diphosphofucose-glycoprotein fucosyltransferase; GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase; FucT; GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase; GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase | |
| 2.4.1.69 | type 1 galactoside alpha-(1,2)-fucosyltransferase | False | 32 | 99 | 5 | 26 | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R | GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting) | None | galactoside 2-alpha-L-fucosyltransferase (ambiguous); blood group H alpha-2-fucosyltransferase (ambiguous); guanosine diphosphofucose-galactoside 2-L-fucosyltransferase; alpha-(1->2)-L-fucosyltransferase (ambiguous); alpha-2-fucosyltransferase (ambiguous); alpha-2-L-fucosyltransferase (ambiguous); blood-group substance H-dependent fucosyltransferase (ambiguous); guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous); guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous); guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous); guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous); secretor-type beta-galactoside alpha1->2fucosyltransferase; beta-galactoside alpha1->2fucosyltransferase (ambiguous); GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous); FUT2 (gene name); GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase | |
| 2.4.1.70 | poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase | False | 1 | 2 | 1 | 1 | n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-alpha-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining) | None | TarM; UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous); uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous); UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase (ambiguous); UDP-N-acetyl-alpha-D-glucosamine:poly(ribitol-phosphate) N-acetyl-alpha-D-glucosaminyltransferase (ambiguous); poly(ribitol-phosphate) N-acetylglucosaminyltransferase (ambiguous) | |
| 2.4.1.71 | arylamine glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine | UDP-glucose:arylamine N-D-glucosyltransferase | None | UDP glucose-arylamine glucosyltransferase; uridine diphosphoglucose-arylamine glucosyltransferase | |
| 2.4.1.73 | lipopolysaccharide glucosyltransferase II | False | 1 | 13 | 0 | 1 | UDP-glucose + lipopolysaccharide = UDP + alpha-D-glucosyl-lipopolysaccharide | UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase | None | uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase | |
| 2.4.1.74 | glycosaminoglycan galactosyltransferase | True | 0 | 0 | 0 | 3 | UDP-alpha-D-galactose + glycosaminoglycan = UDP + D-galactosylglycosaminoglycan | UDP-alpha-D-galactose:glycosaminoglycan D-galactosyltransferase | None | uridine diphosphogalactose-mucopolysaccharide galactosyltransferase; UDP-galactose:glycosaminoglycan D-galactosyltransferase | |
| 2.4.1.78 | phosphopolyprenol glucosyltransferase | False | 0 | 9 | 0 | 2 | UDP-glucose + polyprenyl phosphate = UDP + polyprenylphosphate-glucose | UDP-glucose:phosphopolyprenol D-glucosyltransferase | None | uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase; UDP-glucose:polyprenol monophosphate glucosyltransferase | |
| 2.4.1.79 | globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase | False | 6 | 4 | 0 | 7 | UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase | None | uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase; globoside synthetase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase; globoside synthase; gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase; beta3GalNAc-T1; UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase | |
| 2.4.1.80 | ceramide glucosyltransferase | False | 15 | 4021 | 0 | 21 | UDP-alpha-D-glucose + an N-acylsphingosine = UDP + a beta-D-glucosyl-N-acylsphingosine | UDP-alpha-D-glucose:N-acylsphingosine beta-D-glucosyltransferase (configuration-inverting) | None | UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase | |
| 2.4.1.81 | flavone 7-O-beta-glucosyltransferase | False | 2 | 0 | 0 | 6 | UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone | UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase | None | UDP-glucose-apigenin beta-glucosyltransferase; UDP-glucose-luteolin beta-D-glucosyltransferase; uridine diphosphoglucose-luteolin glucosyltransferase; uridine diphosphoglucose-apigenin 7-O-glucosyltransferase; UDP-glucosyltransferase (ambiguous) | |
| 2.4.1.82 | galactinol---sucrose galactosyltransferase | False | 7 | 2883 | 6 | 12 | alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose | alpha-D-galactosyl-(1->3)-1D-myo-inositol:sucrose 6-alpha-D-galactosyltransferase | None | 1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase; alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase; raffinose synthase; RafS | |
| 2.4.1.83 | dolichyl-phosphate beta-D-mannosyltransferase | False | 15 | 5831 | 0 | 25 | GDP-alpha-D-mannose + dolichyl phosphate = GDP + dolichyl beta-D-mannosyl phosphate | GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase | None | GDP-Man:DolP mannosyltransferase; dolichyl mannosyl phosphate synthase; dolichyl-phospho-mannose synthase; GDP-mannose:dolichyl-phosphate mannosyltransferase; guanosine diphosphomannose-dolichol phosphate mannosyltransferase; dolichol phosphate mannose synthase; dolichyl phosphate mannosyltransferase; dolichyl-phosphate mannose synthase; GDP-mannose-dolichol phosphate mannosyltransferase; GDP-mannose-dolichylmonophosphate mannosyltransferase; mannosylphosphodolichol synthase; mannosylphosphoryldolichol synthase | |
| 2.4.1.85 | cyanohydrin beta-glucosyltransferase | False | 1 | 42 | 2 | 2 | UDP-alpha-D-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxymandelonitrile beta-D-glucoside | UDP-alpha-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase (configuration-inverting) | None | uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase; UDP-glucose-p-hydroxymandelonitrile glucosyltransferase; uridine diphosphoglucose-cyanohydrin glucosyltransferase; uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase; UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase; UGT85B1; UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase; UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase | |
| 2.4.1.86 | N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase | False | 9 | 8 | 0 | 5 | UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R | UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-R 3-beta-D-galactosyltransferase | None | B3GALT1 (gene name); uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase; GalT-4; UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosaminyl-(1->3)-D-galactosyl-(1->4)-D-glucosylceramide 3-beta-D-galactosyltransferase; UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase; UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-D-galactosyltransferase; UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase; glucosaminylgalactosylglucosylceramide beta-galactosyltransferase; UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase | |
| 2.4.1.345 | phosphatidyl-myo-inositol alpha-mannosyltransferase | False | 6 | 1113 | 0 | 2 | GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol | GDP-alpha-D-mannose:1-phosphatidyl-1D-myo-inositol 2-alpha-D-mannosyltransferase (configuration-retaining) | None | mannosyltransferase PimA; PimA; guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase (ambiguous) | |
| 2.4.1.87 | N-acetyllactosaminide 3-alpha-galactosyltransferase | False | 15 | 412 | 11 | 29 | UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) | UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase | None | alpha-galactosyltransferase; UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase; UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase; UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase; UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase; UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase; UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase; glucosaminylglycopeptide alpha-1,3-galactosyltransferase; uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase; uridine diphosphogalactose-acetyllactosamine galactosyltransferase; uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase; beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase; UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase | |
| 2.4.1.88 | globoside alpha-N-acetylgalactosaminyltransferase | False | 2 | 1 | 0 | 5 | UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase | None | uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase; Forssman synthase; globoside acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase | |
| 2.4.1.90 | N-acetyllactosamine synthase | False | 17 | 161 | 12 | 18 | UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine | UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase | None | UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase; uridine diphosphogalactose-acetylglucosamine galactosyltransferase; beta-1,4-galactosyltransferase; acetyllactosamine synthetase; lactosamine synthase; lactosamine synthetase; lactose synthetase A protein; N-acetyllactosamine synthetase; UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase; UDP-galactose-acetylglucosamine galactosyltransferase; UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase; UDP-galactose-N-acetylglucosamine galactosyltransferase; beta1-4-galactosyltransferase; UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase; beta1-4GalT; NAL synthetase; UDP-beta-1,4-galactosyltransferase; Gal-T; UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase; UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase; beta-N-acetylglucosaminide beta1-4-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase | |
| 2.4.1.91 | flavonol 3-O-glucosyltransferase | False | 15 | 85 | 3 | 30 | UDP-glucose + a flavonol = UDP + a flavonol 3-O-beta-D-glucoside | UDP-glucose:flavonol 3-O-D-glucosyltransferase | None | GTI; uridine diphosphoglucose-flavonol 3-O-glucosyltransferase; UDP-glucose:flavonol 3-O-glucosyltransferase; UDPG:flavonoid-3-O-glucosyltransferase | |
| 2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | False | 3 | 6 | 0 | 8 | UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide | UDP-N-acetyl-alpha-D-galactosamine:O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase | None | uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase; ganglioside GM2 synthase; ganglioside GM3 acetylgalactosaminyltransferase; GM2 synthase; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase; GM2/GD2-synthase; beta-1,4N-acetylgalactosaminyltransferase; asialo-GM2 synthase; GalNAc-T; UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase | |
| 2.4.1.94 | protein N-acetylglucosaminyltransferase | False | 0 | 5 | 0 | 3 | UDP-N-acetyl-D-glucosamine + [protein]-L-asparagine = UDP + [protein]-N4-(N-acetyl-D-glucosaminyl)-L-asparagine | UDP-N-acetyl-D-glucosamine:[protein]-L-asparagine beta-N-acetyl-D-glucosaminyl-transferase | None | uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase; uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase; N-acetylglucosaminyltransferase I | |
| 2.4.1.96 | sn-glycerol-3-phosphate 1-galactosyltransferase | True | 0 | 0 | 0 | 4 | UDP-alpha-D-galactose + sn-glycerol 3-phosphate = UDP + 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate | UDP-alpha-D-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase | None | isofloridoside-phosphate synthase; UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase; UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase; uridine diphosphogalactose-glycerol phosphate galactosyltransferase; glycerol 3-phosphate 1alpha-galactosyltransferase; UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase | |
| 2.4.1.97 | 1,3-beta-D-glucan phosphorylase | False | 0 | 3 | 0 | 4 | [(1->3)-beta-D-glucosyl]n + phosphate = [(1->3)-beta-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | (1->3)-beta-D-glucan:phosphate alpha-D-glucosyltransferase | None | laminarin phosphoryltransferase; 1,3-beta-D-glucan:orthophosphate glucosyltransferase; 1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase | |
| 2.4.1.99 | sucrose:sucrose fructosyltransferase | False | 1 | 34 | 0 | 36 | 2 sucrose = D-glucose + beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside | sucrose:sucrose 1'-beta-D-fructosyltransferase | None | SST; sucrose:sucrose 1-fructosyltransferase; sucrose-sucrose 1-fructosyltransferase; sucrose 1F-fructosyltransferase; sucrose:sucrose 1F-beta-D-fructosyltransferase | |
| 2.4.1.100 | 2,1-fructan:2,1-fructan 1-fructosyltransferase | False | 1 | 20 | 1 | 18 | [beta-D-fructosyl-(2->1)-]m + [beta-D-fructosyl-(2->1)-]n = [beta-D-fructosyl-(2->1)-]m-1 + [beta-D-fructosyl-(2->1)-]n+1 | (2->1)-beta-D-fructan:(2->1)-beta-D-fructan 1-beta-D-fructosyltransferase | None | 1,2-beta-D-fructan 1F-fructosyltransferase; fructan:fructan fructosyl transferase; FFT; 1,2-beta-fructan 1F-fructosyltransferase; 1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase; fructan:fructan 1-fructosyl transferase; 2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase | |
| 2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | False | 6 | 3539 | 7 | 20 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | MGAT1 (gene name); N-acetylglucosaminyltransferase I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase; UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I; UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I; alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GnTI; GlcNAc-T I; UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase | False | 19 | 882 | 3 | 12 | UDP-N-acetyl-alpha-D-glucosamine + O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein] = UDP + O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] | UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; beta6-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase; core 2 acetylglucosaminyltransferase; core 6-beta-GlcNAc-transferase A; UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase; GCNT1; GCNT3; UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.103 | alizarin 2-beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + 1,2-dihydroxy-9,10-anthraquinone = UDP + 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone | UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-alizarin glucosyltransferase | |
| 2.4.1.104 | o-dihydroxycoumarin 7-O-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + 7,8-dihydroxycoumarin = UDP + daphnin | UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase; UDP-glucose:o-dihydroxycoumarin glucosyltransferase | |
| 2.4.1.105 | vitexin beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + vitexin = UDP + vitexin 2''-O-beta-D-glucoside | UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-vitexin 2''-glucosyltransferase | |
| 2.4.1.106 | isovitexin beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + isovitexin = UDP + isovitexin 2''-O-beta-D-glucoside | UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-isovitexin 2''-glucosyltransferase | |
| 2.4.1.109 | dolichyl-phosphate-mannose---protein mannosyltransferase | False | 47 | 23715 | 3 | 23 | (1) dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein];;(2) dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-seryl-[protein] | dolichyl beta-D-mannosyl-phosphate:L-threonyl/L-seryl-[protein] O-D-mannosyltransferase (configuration-inverting) | None | dolichol phosphomannose-protein mannosyltransferase; protein O-D-mannosyltransferase; dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase; dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase | |
| 2.4.1.110 | tRNA-queuosine alpha-mannosyltransferase | False | 9 | 3492 | 0 | 1 | GDP-alpha-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp | GDP-alpha-D-mannose:queuosine34 in tRNAAsp O-4''-alpha-D-mannosyltransferase (configuration-retaining) | None | GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase (incorrect); tRNA-queuosine beta-mannosyltransferase (incorrect) | |
| 2.4.1.111 | coniferyl-alcohol glucosyltransferase | False | 2 | 15 | 0 | 12 | UDP-glucose + coniferyl alcohol = UDP + coniferin | UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase | None | uridine diphosphoglucose-coniferyl alcohol glucosyltransferase; UDP-glucose coniferyl alcohol glucosyltransferase | |
| 2.4.1.113 | alpha-1,4-glucan-protein synthase (ADP-forming) | True | 0 | 0 | 0 | 2 | ADP-glucose + protein = ADP + alpha-D-glucosyl-protein | ADP-glucose:protein 4-alpha-D-glucosyltransferase | None | ADP-glucose:protein glucosyltransferase; adenosine diphosphoglucose-protein glucosyltransferase | |
| 2.4.1.114 | 2-coumarate O-beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + trans-2-hydroxycinnamate = UDP + trans-beta-D-glucosyl-2-hydroxycinnamate | UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-o-coumarate glucosyltransferase; UDPG:o-coumaric acid O-glucosyltransferase | |
| 2.4.1.115 | anthocyanidin 3-O-glucosyltransferase | False | 17 | 367 | 5 | 20 | UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside | UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase; UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase; UDP-glucose:cyanidin-3-O-glucosyltransferase; UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase; 3-GT | |
| 2.4.1.116 | cyanidin 3-O-rutinoside 5-O-glucosyltransferase | False | 1 | 0 | 0 | 2 | UDP-alpha-D-glucose + cyanidin-3-O-rutinoside = UDP + cyanidin 3-O-rutinoside 5-O-beta-D-glucoside | UDP-alpha-D-glucose:cyanidin-3-O-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase; cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase; UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase | |
| 2.4.1.117 | dolichyl-phosphate beta-glucosyltransferase | False | 11 | 10633 | 0 | 9 | UDP-alpha-D-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate | UDP-alpha-D-glucose:dolichyl-phosphate beta-D-glucosyltransferase (configuration-inverting) | None | polyprenyl phosphate:UDP-D-glucose glucosyltransferase; UDP-glucose dolichyl-phosphate glucosyltransferase; uridine diphosphoglucose-dolichol glucosyltransferase; UDP-glucose:dolichol phosphate glucosyltransferase; UDP-glucose:dolicholphosphoryl glucosyltransferase; UDP-glucose:dolichyl monophosphate glucosyltransferase; UDP-glucose:dolichyl phosphate glucosyltransferase; UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase | |
| 2.4.1.118 | cytokinin 7-beta-glucosyltransferase | False | 0 | 16 | 0 | 2 | UDP-glucose + an N6-alkylaminopurine = UDP + an N6-alkylaminopurine-7-beta-D-glucoside | UDP-glucose:N6-alkylaminopurine 7-glucosyltransferase | None | uridine diphosphoglucose-zeatin 7-glucosyltransferase; cytokinin 7-glucosyltransferase; UDP-glucose:zeatin 7-glucosyltransferase | |
| 2.4.1.120 | sinapate 1-glucosyltransferase | False | 6 | 11 | 0 | 5 | UDP-alpha-D-glucose + sinapate = UDP + 1-O-sinapoyl-beta-D-glucose | UDP-alpha-D-glucose:sinapate D-glucosyltransferase | None | uridine diphosphoglucose-sinapate glucosyltransferase; UDP-glucose:sinapic acid glucosyltransferase; uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase; UDP-glucose:sinapate D-glucosyltransferase | |
| 2.4.1.121 | indole-3-acetate beta-glucosyltransferase | False | 4 | 40 | 0 | 5 | UDP-glucose + (indol-3-yl)acetate = UDP + 1-O-(indol-3-yl)acetyl-beta-D-glucose | UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase | None | uridine diphosphoglucose-indoleacetate glucosyltransferase; UDPG-indol-3-ylacetyl glucosyl transferase; UDP-glucose:indol-3-ylacetate glucosyltransferase; indol-3-ylacetylglucose synthase; UDP-glucose:indol-3-ylacetate glucosyl-transferase; IAGlu synthase; IAA-glucose synthase; UDP-glucose:indole-3-acetate beta-D-glucosyltransferase | |
| 2.4.1.122 | N-acetylgalactosaminide beta-1,3-galactosyltransferase | False | 12 | 7802 | 1 | 8 | UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R | UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting) | None | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase; uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase; UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase; UDP-Gal:alpha-D-GalNAc-1,3-alpha-D-GalNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase; wbnJ (gene name); wbiP (gene name); C1GALT1 (gene name); UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase | |
| 2.4.1.123 | inositol 3-alpha-galactosyltransferase | False | 12 | 10 | 0 | 20 | UDP-alpha-D-galactose + myo-inositol = UDP + O-alpha-D-galactosyl-(1->3)-1D-myo-inositol | UDP-alpha-D-galactose:myo-inositol 3-alpha-D-galactosyltransferase | None | UDP-D-galactose:inositol galactosyltransferase; UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase; UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase; galactinol synthase; inositol 1-alpha-galactosyltransferase; uridine diphosphogalactose-inositol galactosyltransferase; GolS; UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase | |
| 2.4.1.125 | sucrose---1,6-alpha-glucan 3(6)-alpha-glucosyltransferase | True | 0 | 0 | 0 | 2 | (1) sucrose + [(1->6)-alpha-D-glucosyl]n = D-fructose + [(1->6)-alpha-D-glucosyl]n+1 ;;(2) sucrose + [(1->6)-alpha-D-glucosyl]n = D-fructose + (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n | sucrose:(1->6)-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase | None | water-soluble-glucan synthase (misleading); GTF-I; GTF-S; GTF-SI; sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase; sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase; sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase; sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase; gtfB (gene name); gtfC (gene name); gtfD (gene name) | |
| 2.4.1.126 | hydroxycinnamate 4-beta-glucosyltransferase | False | 2 | 4 | 0 | 2 | UDP-glucose + trans-4-hydroxycinnamate = UDP + 4-O-beta-D-glucosyl-4-hydroxycinnamate | UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-hydroxycinnamate glucosyltransferase; UDP-glucose-hydroxycinnamate glucosyltransferase; hydroxycinnamoyl glucosyltransferase | |
| 2.4.1.127 | monoterpenol beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + (-)-menthol = UDP + (-)-menthyl O-beta-D-glucoside | UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-monoterpenol glucosyltransferase; UDPglucose:monoterpenol glucosyltransferase | |
| 2.4.1.128 | scopoletin glucosyltransferase | False | 1 | 3 | 0 | 5 | UDP-glucose + scopoletin = UDP + scopolin | UDP-glucose:scopoletin O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-scopoletin glucosyltransferase; UDP-glucose:scopoletin glucosyltransferase; SGTase | |
| 2.4.1.394 | 4,6-alpha-glucanotransferase (linear substrates/linear products) | True | 0 | 0 | 0 | 0 | formation of a linear isomalto/malto-polysaccharide from linear malto-oligosaccharides | linear (1->4)-alpha-D-glucan:(1->4)/(1->6)-alpha-D-glucan 6-alpha-D-glucosyltransferase | None | gtfB (gene name) (ambiguous); gtfC (gene name) | |
| 2.4.1.131 | GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase | False | 18 | 4011 | 3 | 7 | 2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol | GDP-alpha-D-mannose:alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase (configuration-retaining) | None | ALG11; ALG11 mannosyltransferase; LEW3 (gene name); At2G40190 (gene name); gmd3 (gene name); galactomannan deficiency protein 3; GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase; glycolipid 2-alpha-mannosyltransferase; GDP-mannose:glycolipid 2-alpha-D-mannosyltransferase; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase; GDP-alpha-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase | |
| 2.4.1.132 | GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase | False | 13 | 4477 | 0 | 8 | GDP-alpha-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol | GDP-alpha-D-mannose:beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-mannosyltransferase (configuration-retaining) | None | Alg2 mannosyltransferase (ambiguous); ALG2 (gene name, ambiguous); glycolipid 3-alpha-mannosyltransferase; GDP-mannose:glycolipid 3-alpha-D-mannosyltransferase; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase; GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase | |
| 2.4.1.133 | xylosylprotein 4-beta-galactosyltransferase | False | 4 | 13 | 0 | 8 | UDP-alpha-D-galactose + [protein]-3-O-(beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine | UDP-alpha-D-galactose:[protein]-3-O-(beta-D-xylosyl)-L-serine 4-beta-D-galactosyltransferase (configuration-inverting) | None | UDP-D-galactose:D-xylose galactosyltransferase; UDP-D-galactose:xylose galactosyltransferase; galactosyltransferase I; uridine diphosphogalactose-xylose galactosyltransferase; UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase; UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase; UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase | |
| 2.4.1.134 | galactosylxylosylprotein 3-beta-galactosyltransferase | False | 4 | 29 | 0 | 5 | UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine | UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting) | None | galactosyltransferase II; uridine diphosphogalactose-galactosylxylose galactosyltransferase; UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase; UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase | |
| 2.4.1.135 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase | False | 16 | 4899 | 5 | 7 | UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine | UDP-alpha-D-glucuronate:[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine D-glucuronosyltransferase (configuration-inverting) | None | glucuronosyltransferase I; uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase; UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase; UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein D-glucuronosyltransferase | |
| 2.4.1.136 | gallate 1-beta-glucosyltransferase | False | 3 | 2 | 0 | 2 | UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose | UDP-glucose:gallate beta-D-glucosyltransferase | None | UDP-glucose---vanillate 1-glucosyltransferase; UDPglucose:vanillate 1-O-glucosyltransferase; UDPglucose:gallate glucosyltransferase | |
| 2.4.1.137 | sn-glycerol-3-phosphate 2-alpha-galactosyltransferase | True | 0 | 0 | 0 | 10 | UDP-alpha-D-galactose + sn-glycerol 3-phosphate = UDP + 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate | UDP-alpha-D-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase | None | floridoside-phosphate synthase; UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase; FPS; UDP-galactose,sn-3-glycerol phosphate:1->2' galactosyltransferase; floridoside phosphate synthetase; floridoside phosphate synthase; UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase | |
| 2.4.1.138 | mannotetraose 2-alpha-N-acetylglucosaminyltransferase | True | 0 | 0 | 0 | 1 | UDP-N-acetyl-alpha-D-glucosamine + alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man = UDP + alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-D-mannose alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining) | None | alpha-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.139 | maltose synthase | True | 0 | 0 | 0 | 1 | 2 alpha-D-glucose 1-phosphate + H2O = maltose + 2 phosphate | alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating) | None | None | |
| 2.4.1.140 | alternansucrase | False | 0 | 3 | 8 | 3 | Transfers alternately an alpha-D-glucosyl residue from sucrose to the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-(1->6)- and alpha-(1->3)-linkages | sucrose:(1->6)[(1->3)]-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase | None | sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase; sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase; sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase | |
| 2.4.1.141 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase | False | 14 | 3402 | 2 | 8 | UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase; uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase; N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase; UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.142 | chitobiosyldiphosphodolichol beta-mannosyltransferase | False | 13 | 1668 | 0 | 5 | GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol | GDP-alpha-D-mannose:N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-D-mannosyltransferase (configuration-inverting) | None | guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase | |
| 2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | False | 5 | 2022 | 3 | 19 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | MGAT2 (gene name); N-acetylglucosaminyltransferase II; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; acetylglucosaminyltransferase II; uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase; UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase; alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GnTII; GlcNAc-T II; UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | False | 3 | 86 | 0 | 6 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | UDP-N-acetyl-alpha-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III; beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; GnTIII; GlcNAc-T III; MGAT3 (gene name); UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | False | 17 | 1235 | 1 | 5 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | N-acetylglucosaminyltransferase IV; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV; beta-acetylglucosaminyltransferase IV; uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV; alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase; GnTIV; UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.146 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase | False | 2 | 0 | 0 | 5 | UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] | UDP-N-acetyl-alpha-D-glucosamine:3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating); elongation 3beta-GalNAc-transferase; UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase; B3GNT3 (gene name) | |
| 2.4.1.147 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase | False | 2 | 8 | 0 | 7 | UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] = UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] | UDP-N-acetyl-alpha-D-glucosamine:O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase | None | O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase; mucin core 3 beta3-GlcNAc-transferase; Core 3beta-GlcNAc-transferase; UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase; UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase (incorrect) | |
| 2.4.1.148 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase | False | 13 | 821 | 0 | 10 | UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R | UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase | None | O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV; uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B; core 4 beta6-GalNAc-transferase; core 6beta-GalNAc-transferase B; UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.149 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase | False | 6 | 11 | 12 | 6 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R | UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting) | None | uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase; poly-N-acetyllactosamine extension enzyme; Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase; UDP-GlcNAc:GalR beta-D-3-N-acetylglucosaminyltransferase; N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase; UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetylglucosaminyltransferase; GnTE; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine 3-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase | False | 15 | 830 | 0 | 12 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R = UDP + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R | UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide 6-beta-N-acetylglucosaminyltransferase (configuration-inverting) | None | GCNT2 (gene name); GCNT3 (gene name); IGnT; I-branching beta1,6-N-acetylglucosaminyltransferase; N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase; Galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.152 | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase | False | 26 | 244 | 12 | 22 | GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R | GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting) | None | Lewis-negative alpha-3-fucosyltransferase; plasma alpha-3-fucosyltransferase; guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase; galactoside 3-fucosyltransferase; GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase; GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase; GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase; GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase | |
| 2.4.1.153 | UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminyltransferase | False | 1 | 33 | 0 | 3 | UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate | UDP-N-acetyl-alpha-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase | None | aglK (gene name); dolichyl-phosphate alpha-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase | False | 7 | 3130 | 13 | 6 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | MGAT5 (gene name); N-acetylglucosaminyltransferase V; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase; UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase; alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase; GnTV; GlcNAc-T V; UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.156 | indolylacetyl-myo-inositol galactosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-galactose + (indol-3-yl)acetyl-myo-inositol = UDP + 5-O-(indol-3-yl)acetyl-myo-inositol D-galactoside | UDP-alpha-D-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase | None | uridine diphosphogalactose-indolylacetylinositol galactosyltransferase; indol-3-ylacetyl-myo-inositol galactoside synthase; UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase; UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase | |
| 2.4.1.158 | 13-hydroxydocosanoate 13-beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + 13-hydroxydocosanoate = UDP + 13-beta-D-glucosyloxydocosanoate | UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase | None | 13-glucosyloxydocosanoate 2'-beta-glucosyltransferase; UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase; uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase; UDP-glucose-13-hydroxydocosanoate glucosyltransferase | |
| 2.4.1.159 | flavonol-3-O-glucoside L-rhamnosyltransferase | False | 1 | 3 | 0 | 2 | UDP-beta-L-rhamnose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] | UDP-beta-L-rhamnose:flavonol-3-O-beta-D-glucoside 6''-O-L-rhamnosyltransferase (configuration-inverting) | None | uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase; UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase; UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase | |
| 2.4.1.160 | pyridoxine 5'-O-beta-D-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + pyridoxine = UDP + 5'-O-beta-D-glucosylpyridoxine | UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase | None | UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase; uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase; UDP-glucose-pyridoxine glucosyltransferase | |
| 2.4.1.161 | oligosaccharide 4-alpha-D-glucosyltransferase | False | 1 | 81 | 9 | 1 | Transfers the non-reducing terminal alpha-D-glucose residue from a (1->4)-alpha-D-glucan to the 4-position of a free glucose or of a glucosyl residue at the non-reducing terminus of a (1->4)-alpha-D-glucan, thus bringing about the rearrangement of oligosaccharides | (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 4-alpha-D-glucosyltransferase | None | amylase III; 1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase; 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase; alpha-1,4-transglucosylase | |
| 2.4.1.162 | aldose beta-D-fructosyltransferase | True | 0 | 0 | 0 | 2 | alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside | alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase | None | None | |
| 2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase | True | 0 | 0 | 0 | 4 | UDP-N-acetyl-alpha-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-N-acetyl-alpha-D-galactosamine:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase | None | uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 4-beta-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase | |
| 2.4.1.166 | raffinose---raffinose alpha-galactosyltransferase | False | 0 | 30 | 0 | 1 | 2 raffinose = 1F-alpha-D-galactosylraffinose + sucrose | raffinose:raffinose alpha-D-galactosyltransferase | None | raffinose (raffinose donor) galactosyltransferase; raffinose:raffinose alpha-galactosyltransferase; raffinose---raffinose alpha-galactotransferase | |
| 2.4.1.167 | sucrose 6F-alpha-galactosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-galactose + sucrose = UDP + 6F-alpha-D-galactosylsucrose | UDP-alpha-D-galactose:sucrose 6F-alpha-D-galactosyltransferase | None | uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase; UDPgalactose:sucrose 6fru-alpha-galactosyltransferase; sucrose 6F-alpha-galactotransferase; UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase | |
| 2.4.1.168 | xyloglucan 4-glucosyltransferase | True | 0 | 0 | 0 | 3 | Transfers a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-(1->4)-D-glucosyl-D-glucose linkage | UDP-glucose:xyloglucan 4-beta-D-glucosyltransferase | None | uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase; xyloglucan 4beta-D-glucosyltransferase; xyloglucan glucosyltransferase; UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase | |
| 2.4.1.170 | isoflavone 7-O-glucosyltransferase | False | 5 | 8 | 0 | 8 | UDP-glucose + an isoflavone = UDP + an isoflavone 7-O-beta-D-glucoside | UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase; UDPglucose-favonoid 7-O-glucosyltransferase; UDPglucose:isoflavone 7-O-glucosyltransferase | |
| 2.4.1.171 | methyl-ONN-azoxymethanol beta-D-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + methyl-ONN-azoxymethanol = UDP + cycasin | UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase | None | cycasin synthase; uridine diphosphoglucose-methylazoxymethanol glucosyltransferase; UDP-glucose-methylazoxymethanol glucosyltransferase | |
| 2.4.1.172 | salicyl-alcohol beta-D-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + salicyl alcohol = UDP + salicin | UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase | None | uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase; UDPglucose:salicyl alcohol phenyl-glucosyltransferase | |
| 2.4.1.173 | sterol 3beta-glucosyltransferase | False | 29 | 1670 | 2 | 27 | UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside | UDP-glucose:sterol 3-O-beta-D-glucosyltransferase | None | UDPG:sterol glucosyltransferase; UDP-glucose-sterol beta-glucosyltransferase; sterol:UDPG glucosyltransferase; UDPG-SGTase; uridine diphosphoglucose-poriferasterol glucosyltransferase; uridine diphosphoglucose-sterol glucosyltransferase; sterol glucosyltransferase; sterol-beta-D-glucosyltransferase; UDP-glucose-sterol glucosyltransferase | |
| 2.4.1.174 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase | False | 5 | 0 | 0 | 5 | UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine | UDP-N-acetyl-D-galactosamine:[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 4-beta-N-acetylgalactosaminyltransferase (configuration-inverting) | None | N-acetylgalactosaminyltransferase I; glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I; UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | |
| 2.4.1.175 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | False | 10 | 101 | 2 | 8 | (1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine;;(2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n+1-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine | UDP-N-acetyl-alpha-D-galactosamine:[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 4-beta-N-acetylgalactosaminyltransferase (configuration-inverting) | None | N-acetylgalactosaminyltransferase II; UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase; chondroitin synthase; glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II; UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase; UDP-N-acetyl-alpha-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | |
| 2.4.1.176 | gibberellin beta-D-glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside | UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-gibberellate 7-glucosyltransferase; uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase | |
| 2.4.1.177 | cinnamate beta-D-glucosyltransferase | False | 6 | 1 | 0 | 9 | UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside | UDP-glucose:trans-cinnamate beta-D-glucosyltransferase | None | uridine diphosphoglucose-cinnamate glucosyltransferase; UDPG:t-cinnamate glucosyltransferase | |
| 2.4.1.178 | hydroxymandelonitrile glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-glucose + 4-hydroxymandelonitrile = UDP + taxiphyllin | UDP-glucose:4-hydroxymandelonitrile glucosyltransferase | None | cyanohydrin glucosyltransferase; uridine diphosphoglucose-cyanohydrin glucosyltransferase | |
| 2.4.1.179 | lactosylceramide beta-1,3-galactosyltransferase | True | 0 | 0 | 0 | 2 | UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-R = UDP + beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R | UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase | None | uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase; UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase; UDP-galactose:D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase; UDP-alpha-D-galactose:D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase | |
| 2.4.1.180 | lipopolysaccharide N-acetylmannosaminouronosyltransferase | False | 62 | 1270 | 0 | 3 | UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-mannosaminouronate:lipid I N-acetyl-alpha-D-mannosaminouronosyltransferase | None | ManNAcA transferase; uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase; UDP-N-acetyl-beta-D-mannosaminouronate:lipid I N-acetyl-beta-D-mannosaminouronosyltransferase (incorrect) | |
| 2.4.1.181 | hydroxyanthraquinone glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + an hydroxyanthraquinone = UDP + a glucosyloxyanthraquinone | UDP-glucose:hydroxyanthraquinone O-glucosyltransferase | None | uridine diphosphoglucose-anthraquinone glucosyltransferase; anthraquinone-specific glucosyltransferase | |
| 2.4.1.182 | lipid-A-disaccharide synthase | False | 258 | 27465 | 5 | 6 | a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a lipid X = UDP + a lipid A disaccharide | UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyltransferase | None | lpxB (gene name); UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase (incorrect) | |
| 2.4.1.183 | alpha-1,3-glucan synthase | False | 5 | 1746 | 0 | 8 | UDP-glucose + [alpha-D-glucosyl-(1->3)]n = UDP + [alpha-D-glucosyl-(1->3)]n+1 | UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase | None | uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase; 1,3-alpha-D-glucan synthase; UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase | |
| 2.4.1.184 | galactolipid galactosyltransferase | False | 2 | 4 | 0 | 3 | 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol | 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol:1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol beta-D-galactosyltransferase | None | galactolipid-galactolipid galactosyltransferase; galactolipid:galactolipid galactosyltransferase; interlipid galactosyltransferase; GGGT; DGDG synthase (ambiguous); digalactosyldiacylglycerol synthase (ambiguous); 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase; 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase; SFR2 (gene name) | |
| 2.4.1.185 | flavanone 7-O-beta-glucosyltransferase | False | 1 | 2 | 0 | 6 | UDP-glucose + a flavanone = UDP + a flavanone 7-O-beta-D-glucoside | UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-flavanone 7-O-glucosyltransferase; naringenin 7-O-glucosyltransferase; hesperetin 7-O-glucosyl-transferase | |
| 2.4.1.186 | glycogenin glucosyltransferase | False | 10 | 3877 | 31 | 13 | UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin | UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase | None | glycogenin; priming glucosyltransferase; UDP-glucose:glycogenin glucosyltransferase | |
| 2.4.1.187 | N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase | False | 10 | 4231 | 4 | 2 | UDP-N-acetyl-alpha-D-mannosamine + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-mannosamine:N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol 4-beta-N-acetylmannosaminyltransferase (configuration-inverting) | None | uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase; N-acetylmannosaminyltransferase; UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase; UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase; UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol 4-beta-N-acetylmannosaminyltransferase; tagA (gene name); tarA (gene name); UDP-N-acetyl-alpha-D-mannosamine:N-acetyl-beta-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-beta-N-acetylmannosaminyltransferase | |
| 2.4.1.188 | N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucose + N-acetyl-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-glucosyl-(1->4)-N-acetyl-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-glucose:N-acetyl-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-beta-D-glucosyltransferase | None | UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase; uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase; UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase | |
| 2.4.1.189 | luteolin 7-O-glucuronosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide | UDP-alpha-D-glucuronate:luteolin 7-O-glucuronosyltransferase (configuration-inverting) | None | uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase; LGT; UDP-glucuronate:luteolin 7-O-glucuronosyltransferase | |
| 2.4.1.190 | luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucuronate + luteolin 7-O-beta-D-glucuronide = UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] | UDP-alpha-D-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase (configuration-inverting) | None | uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase; LMT; UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase; UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase | |
| 2.4.1.191 | luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucuronate + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] = UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D-glucuronide | UDP-alpha-D-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase (configuration-inverting) | None | uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase; UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase; UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase; LDT; UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase | |
| 2.4.1.192 | nuatigenin 3beta-glucosyltransferase | False | 1 | 0 | 0 | 1 | UDP-glucose + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol = UDP + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucoside | UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-nuatigenin glucosyltransferase | |
| 2.4.1.193 | sarsapogenin 3beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + (25S)-5beta-spirostan-3beta-ol = UDP + (25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucoside | UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-sarsapogenin glucosyltransferase | |
| 2.4.1.194 | 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase | False | 2 | 0 | 0 | 3 | UDP-glucose + 4-hydroxybenzoate = UDP + 4-(beta-D-glucosyloxy)benzoate | UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase | None | uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase; UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase; HBA glucosyltransferase; p-hydroxybenzoate glucosyltransferase; PHB glucosyltransferase; PHB-O-glucosyltransferase | |
| 2.4.1.195 | N-hydroxythioamide S-beta-glucosyltransferase | False | 1 | 6 | 0 | 11 | (1) UDP-alpha-D-glucose + (Z)-2-phenyl-1-thioacetohydroximate = UDP + desulfoglucotropeolin;; (2) UDP-alpha-D-glucose + an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate = UDP + an aliphatic desulfoglucosinolate;;(3) UDP-alpha-D-glucose + (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate = UDP + desulfoglucobrassicin | UDP-alpha-D-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase | None | UGT74B1 (gene name); desulfoglucosinolate-uridine diphosphate glucosyltransferase; uridine diphosphoglucose-thiohydroximate glucosyltransferase; thiohydroximate beta-D-glucosyltransferase; UDPG:thiohydroximate glucosyltransferase; thiohydroximate S-glucosyltransferase; thiohydroximate glucosyltransferase; UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase; UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase | |
| 2.4.1.196 | nicotinate glucosyltransferase | False | 0 | 1 | 0 | 3 | UDP-glucose + nicotinate = UDP + N-glucosylnicotinate | UDP-glucose:nicotinate N-glucosyltransferase | None | uridine diphosphoglucose-nicotinate N-glucosyltransferase; UDP-glucose:nicotinic acid-N-glucosyltransferase | |
| 2.4.1.197 | high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase | True | 0 | 0 | 0 | 1 | Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-(1->6) to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum | UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide 4-beta-N-acetylglucosaminyltransferase | None | uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase; acetylglucosamine-oligosaccharide acetylglucosaminyltransferase; UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase | |
| 2.4.1.198 | phosphatidylinositol N-acetylglucosaminyltransferase | False | 18 | 3463 | 0 | 40 | UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | UDP-N-acetyl-alpha-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase (configuration-retaining) | None | UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase; uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase; UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase | |
| 2.4.1.199 | beta-mannosylphosphodecaprenol---mannooligosaccharide 6-mannosyltransferase | True | 0 | 0 | 0 | 1 | beta-D-mannosylphosphodecaprenol + (1->6)-alpha-D-mannosyloligosaccharide = decaprenol phosphate + (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide | beta-D-mannosylphosphodecaprenol:(1->6)-alpha-D-mannosyloligosaccharide 6-alpha-D-mannosyltransferase | None | mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase; beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase | |
| 2.4.1.201 | alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | False | 1 | 38 | 0 | 5 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->2)]-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | MGAT4C (gene name); N-acetylglucosaminyltransferase VI; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI; uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI; mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; GnTVI; GlcNAc-T VI; UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.202 | 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase | False | 2 | 0 | 0 | 1 | (1) UDP-alpha-D-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside;;(2) UDP-alpha-D-glucose + 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside | UDP-alpha-D-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-beta-D-glucosyltransferase | None | uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase; BX8; BX9; benzoxazinoid glucosyltransferase; DIMBOA glucosyltransferase | |
| 2.4.1.203 | trans-zeatin O-beta-D-glucosyltransferase | False | 1 | 30 | 0 | 9 | UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin | UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase | None | zeatin O-beta-D-glucosyltransferase; uridine diphosphoglucose-zeatin O-glucosyltransferase; zeatin O-glucosyltransferase | |
| 2.4.1.205 | galactogen 6beta-galactosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-galactose + galactogen = UDP + (1->6)-beta-D-galactosylgalactogen | UDP-alpha-D-galactose:galactogen 6-beta-D-galactosyltransferase | None | uridine diphosphogalactose-galactogen galactosyltransferase; 1,6-D-galactosyltransferase; beta-(1-6)-D-galactosyltransferase; UDP-galactose:galactogen beta-1,6-D-galactosyltransferase | |
| 2.4.1.206 | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase | False | 9 | 4 | 0 | 5 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting) | None | LA2 synthase; beta1->3-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase; lactosylceramide beta-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase | |
| 2.4.1.207 | xyloglucan:xyloglucosyl transferase | False | 48 | 11270 | 2 | 127 | breaks a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan | xyloglucan:xyloglucan xyloglucanotransferase | None | endo-xyloglucan transferase; xyloglucan endotransglycosylase | |
| 2.4.1.208 | diglucosyl diacylglycerol synthase (1,2-linking) | False | 1 | 27 | 0 | 4 | UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->2)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP | UDP-alpha-D-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol 2-glucosyltransferase | None | monoglucosyl diacylglycerol (1->2) glucosyltransferase; MGlcDAG (1->2) glucosyltransferase; DGlcDAG synthase (ambiguous); UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase; diglucosyl diacylglycerol synthase | |
| 2.4.1.209 | cis-p-coumarate glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-glucose + cis-p-coumarate = 4'-O-beta-D-glucosyl-cis-p-coumarate + UDP | UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase | None | None | |
| 2.4.1.210 | limonoid glucosyltransferase | False | 1 | 14 | 0 | 10 | UDP-alpha-D-glucose + limonin = limonin 17-O-beta-D-glucoside + UDP | UDP-alpha-D-glucose:limonin 17-O-beta-D-glucosyltransferase (configuration-inverting) | None | uridine diphosphoglucose-limonoid glucosyltransferase; UDP-glucose:limonin glucosyltransferase | |
| 2.4.1.211 | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | False | 3 | 765 | 6 | 7 | beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactopyranose 1-phosphate + N-acetyl-D-glucosamine | beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase | None | lacto-N-biose phosphorylase; LNBP; galacto-N-biose phosphorylase | |
| 2.4.1.212 | hyaluronan synthase | False | 22 | 3356 | 3 | 15 | (1) UDP-N-acetyl-alpha-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan];;(2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] | Alternating UDP-N-acetyl-alpha-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase (configuration-inverting) | None | spHAS; seHAS; Alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase | |
| 2.4.1.213 | glucosylglycerol-phosphate synthase | False | 3 | 391 | 0 | 5 | ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP | ADP-alpha-D-glucose:sn-glycerol-3-phosphate 2-alpha-D-glucopyranosyltransferase | None | ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase (incorrect) | |
| 2.4.1.214 | glycoprotein 3-alpha-L-fucosyltransferase | False | 3 | 101 | 0 | 15 | GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] | GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 3-alpha-L-fucosyltransferase (configuration-retaining) | None | GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase; GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase; GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase; GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase; GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase; GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase | |
| 2.4.1.215 | cis-zeatin O-beta-D-glucosyltransferase | False | 3 | 7 | 0 | 4 | UDP-glucose + cis-zeatin = UDP + O-beta-D-glucosyl-cis-zeatin | UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase | None | None | |
| 2.4.1.216 | trehalose 6-phosphate phosphorylase | False | 1 | 65 | 0 | 24 | alpha,alpha-trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate | alpha,alpha-trehalose 6-phosphate:phosphate beta-D-glucosyltransferase | None | trehalose 6-phosphate:phosphate beta-D-glucosyltransferase | |
| 2.4.1.217 | mannosyl-3-phosphoglycerate synthase | False | 4 | 251 | 13 | 7 | GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate | GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase | None | MPG synthase; GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase | |
| 2.4.1.218 | hydroquinone glucosyltransferase | False | 2 | 89 | 3 | 2 | UDP-glucose + hydroquinone = UDP + hydroquinone-O-beta-D-glucopyranoside | UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase | None | arbutin synthase; hydroquinone:O-glucosyltransferase | |
| 2.4.1.219 | vomilenine glucosyltransferase | False | 1 | 1 | 0 | 4 | UDP-glucose + vomilenine = UDP + raucaffricine | UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase | None | UDPG:vomilenine 21-beta-D-glucosyltransferase | |
| 2.4.1.220 | indoxyl-UDPG glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-glucose + indoxyl = UDP + indican | UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase | None | indoxyl-UDPG-glucosyltransferase | |
| 2.4.1.221 | peptide-O-fucosyltransferase | False | 17 | 3593 | 21 | 11 | GDP-beta-L-fucose + [protein]-(L-serine/L-threonine) = GDP + [protein]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) | GDP-beta-L-fucose:protein-(L-serine/L-threonine) O-alpha-L-fucosyltransferase (configuration-inverting) | None | GDP-L-fucose:polypeptide fucosyltransferase; GDP-fucose protein O-fucosyltransferase; GDP-fucose:polypeptide fucosyltransferase; POFUT1 (gene name); POFUT2 (gene name) | |
| 2.4.1.222 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | False | 19 | 1943 | 2 | 8 | UDP-N-acetyl-alpha-D-glucosamine + [protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) = UDP + [protein with EGF-like domain]-3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl]-(L-serine/L-threonine) | UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase; fringe; UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.223 | glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | False | 6 | 41 | 4 | 5 | UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine | UDP-N-acetyl-alpha-D-glucosamine:[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 4IV-alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining) | None | alpha-N-acetylglucosaminyltransferase I; alpha1,4-N-acetylglucosaminyltransferase; glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | |
| 2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | False | 11 | 131 | 6 | 9 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | None | alpha-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase | |
| 2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase | False | 12 | 50 | 0 | 8 | UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan | UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase | None | N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase; heparan glucuronyltransferase II | |
| 2.4.1.226 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase | False | 12 | 141 | 0 | 6 | (1) UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine;;(2) UDP-alpha-D-glucuronate + [protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine | UDP-alpha-D-glucuronate:[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 3-beta-glucuronosyltransferase (configuration-inverting) | None | chondroitin glucuronyltransferase II; alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase; UDP-alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase | |
| 2.4.1.227 | undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase | False | 688 | 40377 | 2 | 9 | UDP-N-acetyl-alpha-D-glucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase (configuration-inverting) | None | MurG transferase; UDP-N-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase; UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase | |
| 2.4.1.228 | lactosylceramide 4-alpha-galactosyltransferase | False | 6 | 748 | 0 | 4 | UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase | None | Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase; globotriaosylceramide/CD77 synthase; histo-blood group Pk UDP-galactose; UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase | |
| 2.4.1.229 | [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase | False | 1 | 36 | 0 | 7 | UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline = UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline | UDP-N-acetyl-alpha-D-glucosamine:[Skp1-protein]-trans-4-hydroxy-L-proline N-acetyl-alpha-D-glucosaminyl-transferase | None | Skp1-HyPro GlcNAc-transferase; UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase; UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase; UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase; UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase | |
| 2.4.1.230 | kojibiose phosphorylase | False | 3 | 481 | 2 | 5 | 2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate | 2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase | None | None | |
| 2.4.1.231 | alpha,alpha-trehalose phosphorylase (configuration-retaining) | False | 3 | 10 | 0 | 12 | alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate | alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase | None | trehalose phosphorylase[ambiguous] | |
| 2.4.1.232 | initiation-specific alpha-1,6-mannosyltransferase | False | 3 | 69 | 0 | 9 | Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage | GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase | None | alpha-1,6-mannosyltransferase; GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase; GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase; glycolipid 6-alpha-mannosyltransferase; GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase | |
| 2.4.1.234 | kaempferol 3-O-galactosyltransferase | False | 1 | 4 | 0 | 9 | UDP-alpha-D-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside | UDP-alpha-D-galactose:kaempferol 3-O-beta-D-galactosyltransferase | None | F3GalTase; UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase | |
| 2.4.1.236 | flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase | False | 1 | 0 | 0 | 4 | UDP-beta-L-rhamnose + a flavanone 7-O-beta-D-glucoside = UDP + a flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] | UDP-beta-L-rhamnose:flavanone-7-O-glucoside 2''-O-alpha-L-rhamnosyltransferase | None | UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase; 1->2 UDP-rhamnosyltransferase; UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase | |
| 2.4.1.237 | flavonol 7-O-beta-glucosyltransferase | False | 6 | 25 | 0 | 7 | UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside | UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase | None | UDP-glucose:flavonol 7-O-glucosyltransferase | |
| 2.4.1.238 | delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-glucose + delphinidin 3,5-di-O-beta-D-glucoside = UDP + delphinidin 3,3',5-tri-O-beta-D-glucoside | UDP-alpha-D-glucose:delphinidin-3,5-di-O-beta-D-glucoside 3'-O-glucosyltransferase | None | UDP-glucose:anthocyanin 3'-O-glucosyltransferase; 3'GT | |
| 2.4.1.239 | flavonol-3-O-glucoside glucosyltransferase | False | 2 | 0 | 0 | 2 | UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside | UDP-glucose:flavonol-3-O-beta-D-glucoside 2''-O-beta-D-glucosyltransferase | None | UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase | |
| 2.4.1.240 | flavonol-3-O-glycoside glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside | UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase | None | None | |
| 2.4.1.241 | digalactosyldiacylglycerol synthase | False | 6 | 1112 | 1 | 8 | UDP-alpha-D-galactose + 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = UDP + 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol | UDP-alpha-D-galactose:1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol 6-alpha-galactosyltransferase | None | DGD1; DGD2; DGDG synthase (ambiguous); UDP-galactose-dependent DGDG synthase; UDP-galactose-dependent digalactosyldiacylglycerol synthase; UDP-galactose:MGDG galactosyltransferase; UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase | |
| 2.4.1.242 | NDP-glucose---starch glucosyltransferase | False | 17 | 43 | 2 | 34 | NDP-glucose + [(1->4)-alpha-D-glucosyl]n = NDP + [(1->4)-alpha-D-glucosyl]n+1 | NDP-glucose:(1->4)-alpha-D-glucan 4-alpha-D-glucosyltransferase | None | granule-bound starch synthase; starch synthase II (ambiguous); waxy protein; starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase; granule-bound starch synthase I; GBSSI; granule-bound starch synthase II; GBSSII; GBSS; NDPglucose-starch glucosyltransferase | |
| 2.4.2.1 | purine-nucleoside phosphorylase | False | 456 | 47450 | 227 | 85 | (1) purine ribonucleoside + phosphate = purine + alpha-D-ribose 1-phosphate;;(2) purine 2'-deoxyribonucleoside + phosphate = purine + 2-deoxy-alpha-D-ribose 1-phosphate | purine-nucleoside:phosphate ribosyltransferase | None | inosine phosphorylase; PNPase (ambiguous); PUNPI; PUNPII; inosine-guanosine phosphorylase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase | |
| 2.4.2.2 | pyrimidine-nucleoside phosphorylase | False | 201 | 12681 | 6 | 16 | (1) uridine + phosphate = uracil + alpha-D-ribose 1-phosphate;;(2) cytidine + phosphate = cytosine + alpha-D-ribose 1-phosphate;;(3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate;;(4) thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate | pyrimidine-nucleoside:phosphate (2'-deoxy)-alpha-D-ribosyltransferase | None | Py-NPase; pdp (gene name) | |
| 2.4.2.3 | uridine phosphorylase | False | 14 | 18586 | 99 | 28 | uridine + phosphate = uracil + alpha-D-ribose 1-phosphate | uridine:phosphate alpha-D-ribosyltransferase | None | pyrimidine phosphorylase; UrdPase; UPH; UPase | |
| 2.4.2.4 | thymidine phosphorylase | False | 143 | 12384 | 19 | 11 | thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate | thymidine:phosphate deoxy-alpha-D-ribosyltransferase | None | pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase | |
| 2.4.2.5 | nucleoside ribosyltransferase | True | 0 | 0 | 0 | 3 | D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1 | nucleoside:purine(pyrimidine) D-ribosyltransferase | None | nucleoside N-ribosyltransferase | |
| 2.4.2.6 | nucleoside deoxyribosyltransferase | False | 3 | 160 | 14 | 16 | 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 | nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase | None | purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase; deoxyribose transferase; nucleoside trans-N-deoxyribosylase; trans-deoxyribosylase; trans-N-deoxyribosylase; trans-N-glycosidase; nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases); nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase] | |
| 2.4.2.7 | adenine phosphoribosyltransferase | False | 644 | 37163 | 41 | 29 | AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate | AMP:diphosphate phospho-D-ribosyltransferase | None | AMP pyrophosphorylase; transphosphoribosidase; APRT; AMP-pyrophosphate phosphoribosyltransferase; adenine phosphoribosylpyrophosphate transferase; adenosine phosphoribosyltransferase; adenylate pyrophosphorylase; adenylic pyrophosphorylase | |
| 2.4.2.8 | hypoxanthine phosphoribosyltransferase | False | 102 | 33675 | 97 | 40 | IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | IMP:diphosphate phospho-D-ribosyltransferase | None | IMP pyrophosphorylase; transphosphoribosidase; hypoxanthine---guanine phosphoribosyltransferase; guanine phosphoribosyltransferase; GPRT; HPRT; guanosine 5'-phosphate pyrophosphorylase; IMP-GMP pyrophosphorylase; HGPRTase; 6-hydroxypurine phosphoribosyltransferase; 6-mercaptopurine phosphoribosyltransferase; GMP pyrophosphorylase; guanine-hypoxanthine phosphoribosyltransferase; guanosine phosphoribosyltransferase; guanylate pyrophosphorylase; guanylic pyrophosphorylase; inosinate pyrophosphorylase; inosine 5'-phosphate pyrophosphorylase; inosinic acid pyrophosphorylase; inosinic pyrophosphorylase; purine-6-thiol phosphoribosyltransferase | |
| 2.4.2.9 | uracil phosphoribosyltransferase | False | 704 | 48458 | 27 | 23 | UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate | UMP:diphosphate phospho-alpha-D-ribosyltransferase | None | UMP pyrophosphorylase; UPRTase; UMP:pyrophosphate phosphoribosyltransferase; uridine 5'-phosphate pyrophosphorylase; uridine monophosphate pyrophosphorylase; uridylate pyrophosphorylase; uridylic pyrophosphorylase | |
| 2.4.2.10 | orotate phosphoribosyltransferase | False | 471 | 46455 | 54 | 17 | orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate | orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase | None | orotidylic acid phosphorylase; orotidine-5'-phosphate pyrophosphorylase; OPRTase; orotate phosphoribosyl pyrophosphate transferase; orotic acid phosphoribosyltransferase; orotidine 5'-monophosphate pyrophosphorylase; orotidine monophosphate pyrophosphorylase; orotidine phosphoribosyltransferase; orotidylate phosphoribosyltransferase; orotidylate pyrophosphorylase; orotidylic acid pyrophosphorylase; orotidylic phosphorylase; orotidylic pyrophosphorylase | |
| 2.4.2.12 | nicotinamide phosphoribosyltransferase | False | 7 | 5709 | 90 | 5 | nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase | None | NMN pyrophosphorylase; nicotinamide mononucleotide pyrophosphorylase; nicotinamide mononucleotide synthetase; NMN synthetase; nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase | |
| 2.4.2.14 | amidophosphoribosyltransferase | False | 41 | 42985 | 10 | 18 | 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O | 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | None | phosphoribosyldiphosphate 5-amidotransferase; glutamine phosphoribosyldiphosphate amidotransferase; alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase; 5'-phosphoribosylpyrophosphate amidotransferase; 5-phosphoribosyl-1-pyrophosphate amidotransferase; 5-phosphororibosyl-1-pyrophosphate amidotransferase; glutamine 5-phosphoribosylpyrophosphate amidotransferase; glutamine ribosylpyrophosphate 5-phosphate amidotransferase; phosphoribose pyrophosphate amidotransferase; phosphoribosyl pyrophosphate amidotransferase; phosphoribosylpyrophosphate glutamyl amidotransferase; 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | |
| 2.4.2.15 | guanosine phosphorylase | True | 0 | 0 | 0 | 2 | guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate | guanosine:phosphate alpha-D-ribosyltransferase | None | None | |
| 2.4.2.16 | urate-ribonucleoside phosphorylase | True | 0 | 0 | 0 | 4 | urate D-ribonucleoside + phosphate = urate + alpha-D-ribose 1-phosphate | urate-D-ribonucleoside:phosphate alpha-D-ribosyltransferase | None | UAR phosphorylase; urate-ribonucleotide:phosphate D-ribosyltransferase (incorrect); urate-ribonucleotide:phosphate alpha-D-ribosyltransferase (incorrect); urate-ribonucleotide phosphorylase (incorrect) | |
| 2.4.2.17 | ATP phosphoribosyltransferase | False | 532 | 38674 | 42 | 15 | 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate | 1-(5-phospho-beta-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase | None | phosphoribosyl-ATP pyrophosphorylase; adenosine triphosphate phosphoribosyltransferase; phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase; phosphoribosyl ATP synthetase; phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase; phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase; phosphoribosyladenosine triphosphate pyrophosphorylase; phosphoribosyladenosine triphosphate synthetase; 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase | |
| 2.4.2.18 | anthranilate phosphoribosyltransferase | False | 573 | 35425 | 63 | 32 | N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate | N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase | None | phosphoribosyl-anthranilate pyrophosphorylase; PRT; anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase; anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase; phosphoribosylanthranilate pyrophosphorylase; phosphoribosylanthranilate transferase; anthranilate-PP-ribose-P phosphoribosyltransferase | |
| 2.4.2.19 | nicotinate-nucleotide diphosphorylase (carboxylating) | False | 30 | 36393 | 28 | 22 | beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | beta-nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating) | None | quinolinate phosphoribosyltransferase (decarboxylating); quinolinic acid phosphoribosyltransferase; QAPRTase; NAD+ pyrophosphorylase; nicotinate mononucleotide pyrophosphorylase (carboxylating); quinolinic phosphoribosyltransferase | |
| 2.4.2.20 | dioxotetrahydropyrimidine phosphoribosyltransferase | True | 0 | 0 | 0 | 1 | a 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate = a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate | 2,4-dioxotetrahydropyrimidine-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase | None | dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase; dioxotetrahydropyrimidine phosphoribosyl transferase; dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase; 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase | |
| 2.4.2.21 | nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase | False | 205 | 20817 | 40 | 7 | beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate | nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase | None | nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase; nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase; nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase; CobT; nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase | |
| 2.4.2.22 | xanthine phosphoribosyltransferase | False | 304 | 13356 | 13 | 12 | XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine | XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase | None | Xan phosphoribosyltransferase; xanthosine 5'-phosphate pyrophosphorylase; xanthylate pyrophosphorylase; xanthylic pyrophosphorylase; XMP pyrophosphorylase; 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase; 9-(5-phospho-beta-D-ribosyl)xanthine:diphosphate 5-phospho-alpha-D-ribosyltransferase | |
| 2.4.2.24 | 1,4-beta-D-xylan synthase | False | 2 | 57 | 0 | 14 | UDP-D-xylose + [(1->4)-beta-D-xylan]n = UDP + [(1->4)-beta-D-xylan]n+1 | UDP-D-xylose:(1->4)-beta-D-xylan 4-beta-D-xylosyltransferase | None | uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase; 1,4-beta-xylan synthase; xylan synthase; xylan synthetase; UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase | |
| 2.4.2.25 | flavone apiosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-apiose + apigenin 7-O-beta-D-glucoside = UDP + apigenin 7-O-[beta-D-apiosyl-(1->2)-beta-D-glucoside] | UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase | None | uridine diphosphoapiose-flavone apiosyltransferase; UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase | |
| 2.4.2.26 | protein xylosyltransferase | False | 17 | 3265 | 9 | 8 | UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | UDP-alpha-D-xylose:protein beta-D-xylosyltransferase (configuration-inverting) | None | UDP-D-xylose:core protein beta-D-xylosyltransferase; UDP-D-xylose:core protein xylosyltransferase; UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase; UDP-xylose-core protein beta-D-xylosyltransferase; uridine diphosphoxylose-core protein beta-xylosyltransferase; uridine diphosphoxylose-protein xylosyltransferase; UDP-D-xylose:protein beta-D-xylosyltransferase | |
| 2.4.2.27 | dTDP-dihydrostreptose---streptidine-6-phosphate dihydrostreptosyltransferase | False | 1 | 1 | 0 | 1 | dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate | dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase | None | thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase | |
| 2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase | False | 99 | 11410 | 47 | 21 | S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate | S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase | None | 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase | |
| 2.4.2.29 | tRNA-guanosine34 preQ1 transglycosylase | False | 461 | 36200 | 187 | 14 | guanine34 in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7-carbaguanine34 in tRNA + guanine | tRNA-guanosine34:7-aminomethyl-7-deazaguanine tRNA-D-ribosyltransferase | None | guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase (ambiguous); TGT (ambiguous); transfer ribonucleic acid guanine34 transglycosylase (ambiguous) | |
| 2.4.2.64 | tRNA-guanosine34 queuine transglycosylase | False | 10 | 2922 | 1 | 15 | guanine34 in tRNA + queuine = queuine34 in tRNA + guanine | tRNA-guanosine34:queuine tRNA-D-ribosyltransferase | None | QTRT1 (gene name); QTRT2 (gene name); TGT (ambiguous); guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); queuine34 transfer ribonucleate ribosyltransferase; transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase (ambiguous); queuine tRNA-ribosyltransferase; [tRNA]-guanine34:queuine tRNA-D-ribosyltransferase; transfer ribonucleic acid guanine34 transglycosylase (ambiguous) | |
| 2.4.2.30 | NAD+ ADP-ribosyltransferase | False | 31 | 2516 | 414 | 26 | NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase | None | poly(ADP-ribose) synthase; ADP-ribosyltransferase (polymerizing); NAD ADP-ribosyltransferase; PARP; PARP-1; NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect); NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase | |
| 2.4.2.31 | NAD+---protein-arginine ADP-ribosyltransferase | False | 43 | 20474 | 23 | 26 | NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine | NAD+:protein-L-arginine ADP-D-ribosyltransferase | None | ADP-ribosyltransferase; mono(ADP-ribosyl)transferase; NAD+:L-arginine ADP-D-ribosyltransferase; NAD(P)+-arginine ADP-ribosyltransferase; NAD(P)+:L-arginine ADP-D-ribosyltransferase; mono-ADP-ribosyltransferase; ART; ART1; ART2; ART3; ART4; ART5; ART6; ART7; NAD(P)+---protein-arginine ADP-ribosyltransferase; NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase | |
| 2.4.2.32 | dolichyl-phosphate D-xylosyltransferase | True | 0 | 0 | 0 | 1 | UDP-D-xylose + dolichyl phosphate = UDP + dolichyl D-xylosyl phosphate | UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase | None | None | |
| 2.4.2.33 | dolichyl-xylosyl-phosphate---protein xylosyltransferase | True | 0 | 0 | 0 | 1 | dolichyl D-xylosyl phosphate + protein = dolichyl phosphate + D-xylosylprotein | dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase | None | None | |
| 2.4.2.34 | indolylacetylinositol arabinosyltransferase | False | 0 | 36 | 7 | 1 | UDP-L-arabinose + (indol-3-yl)acetyl-1D-myo-inositol = UDP + (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside | UDP-L-arabinose:(indol-3-yl)acetyl-1D-myo-inositol L-arabinosyltransferase | None | arabinosylindolylacetylinositol synthase; UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase; UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase | |
| 2.4.2.35 | flavonol-3-O-glycoside xylosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-xylose + a flavonol 3-O-glycoside = UDP + a flavonol 3-[beta-D-xylosyl-(1->2)-beta-D-glycoside] | UDP-alpha-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase | None | UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase | |
| 2.4.2.36 | NAD+---diphthamide ADP-ribosyltransferase | False | 4 | 19 | 29 | 6 | NAD+ + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] | NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase | None | ADP-ribosyltransferase; mono(ADPribosyl)transferase; NAD---diphthamide ADP-ribosyltransferase; NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase | |
| 2.4.2.37 | NAD+---dinitrogen-reductase ADP-D-ribosyltransferase | False | 1 | 96 | 0 | 4 | NAD+ + [dinitrogen reductase]-L-arginine = nicotinamide + [dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine | NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase | None | NAD-azoferredoxin (ADPribose)transferase; NAD-dinitrogen-reductase ADP-D-ribosyltransferase; draT (gene name) | |
| 2.4.2.38 | glycoprotein 2-beta-D-xylosyltransferase | False | 1 | 47 | 0 | 23 | UDP-alpha-D-xylose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = UDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] | UDP-alpha-D-xylose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 2-beta-D-xylosyltransferase (configuration-inverting) | None | beta1,2-xylosyltransferase; UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase; UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase | |
| 2.4.2.39 | xyloglucan 6-xylosyltransferase | False | 7 | 90 | 3 | 6 | Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-(1->6)-D-xylosyl-D-glucose linkage | UDP-D-xylose:xyloglucan 6-alpha-D-xylosyltransferase | None | uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase; xyloglucan 6-alpha-D-xylosyltransferase; UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase | |
| 2.4.2.40 | zeatin O-beta-D-xylosyltransferase | False | 1 | 0 | 0 | 1 | UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin | UDP-D-xylose:zeatin O-beta-D-xylosyltransferase | None | uridine diphosphoxylose-zeatin xylosyltransferase; zeatin O-xylosyltransferase | |
| 2.5.1.1 | dimethylallyltranstransferase | False | 96 | 2309 | 61 | 24 | prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + geranyl diphosphate | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate prenyltranstransferase | None | geranyl-diphosphate synthase; prenyltransferase; dimethylallyltransferase; DMAPP:IPP-dimethylallyltransferase; (2E,6E)-farnesyl diphosphate synthetase; diprenyltransferase; geranyl pyrophosphate synthase; geranyl pyrophosphate synthetase; trans-farnesyl pyrophosphate synthetase; dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase | |
| 2.5.1.2 | thiamine pyridinylase | False | 1 | 91 | 8 | 83 | thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole | thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase | None | pyrimidine transferase; thiaminase I; thiamin hydrolase; thiamin pyridinolase; thiaminase (ambiguous); thiamine pyridinolase; thiamin pyridinylase; thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase | |
| 2.5.1.3 | thiamine phosphate synthase | False | 346 | 34300 | 18 | 14 | (1) 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = diphosphate + thiamine phosphate + CO2;;(2) 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO2;;(3) 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole = diphosphate + thiamine phosphate | 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine:2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 4-amino-2-methylpyrimidine-5-methenyltransferase (decarboxylating) | None | thiamine phosphate pyrophosphorylase; thiamine monophosphate pyrophosphorylase; TMP-PPase; thiamine-phosphate diphosphorylase; thiE (gene name); TH1 (gene name); THI6 (gene name); 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase; 4-amino-2-methyl-5-diphosphomethylpyrimidine:2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 4-amino-2-methylpyrimidine-5-methenyltransferase (decarboxylating) | |
| 2.5.1.5 | galactose-6-sulfurylase | False | 0 | 6 | 0 | 4 | Eliminates sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues | D-galactose-6-sulfate:alkyltransferase (cyclizing) | None | porphyran sulfatase; galactose-6-sulfatase; galactose 6-sulfatase | |
| 2.5.1.6 | methionine adenosyltransferase | False | 785 | 54950 | 122 | 54 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine | ATP:L-methionine S-adenosyltransferase | None | adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase | |
| 2.5.1.7 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | False | 568 | 51880 | 57 | 20 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase | None | MurA transferase; UDP-N-acetylglucosamine 1-carboxyvinyl-transferase; UDP-N-acetylglucosamine enoylpyruvyltransferase; enoylpyruvate transferase; phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase; phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase; phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase; phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase; phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase; pyruvate-UDP-acetylglucosamine transferase; pyruvate-uridine diphospho-N-acetylglucosamine transferase; pyruvate-uridine diphospho-N-acetyl-glucosamine transferase; pyruvic-uridine diphospho-N-acetylglucosaminyltransferase; phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase | |
| 2.5.1.9 | riboflavin synthase | False | 27 | 40994 | 22 | 30 | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine | 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase | None | heavy riboflavin synthase; light riboflavin synthase; riboflavin synthetase; riboflavine synthase; riboflavine synthetase | |
| 2.5.1.10 | (2E,6E)-farnesyl diphosphate synthase | False | 109 | 3262 | 119 | 48 | geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate | geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase | None | farnesyl-diphosphate synthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase | |
| 2.5.1.15 | dihydropteroate synthase | False | 52 | 45993 | 79 | 27 | (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate | (7,8-dihydropterin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase | None | dihydropteroate pyrophosphorylase; DHPS; 7,8-dihydropteroate synthase; 7,8-dihydropteroate synthetase; 7,8-dihydropteroic acid synthetase; dihydropteroate synthetase; dihydropteroic synthetase; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase; (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | |
| 2.5.1.16 | spermidine synthase | False | 228 | 21792 | 55 | 39 | S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine | S-adenosyl 3-(methylsulfanyl)propylamine:putrescine 3-aminopropyltransferase | None | aminopropyltransferase; putrescine aminopropyltransferase; spermidine synthetase; SpeE (ambiguous); S-adenosylmethioninamine:putrescine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase | |
| 2.5.1.17 | corrinoid adenosyltransferase | False | 11 | 40793 | 29 | 18 | (1) 2 ATP + 2 cob(II)alamin + a reduced flavoprotein = 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein (overall reaction);;(1a) 2 cob(II)alamin + 2 [corrinoid adenosyltransferase] = 2 [corrinoid adenosyltransferase]-cob(II)alamin;;(1b) a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)alamin = an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)alamin (spontaneous);;(1c) 2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)alamin = 2 triphosphate + 2 adenosylcob(III)alamin + 2 [corrinoid adenosyltransferase];;(2) 2 ATP + 2 cob(II)yrinic acid a,c-diamide + a reduced flavoprotein = 2 triphosphate + 2 adenosylcob(III)yrinic acid a,c-diamide + an oxidized flavoprotein (overall reaction);;(2a) 2 cob(II)yrinic acid a,c-diamide + 2 [corrinoid adenosyltransferase] = 2 [corrinoid adenosyltransferase]-cob(II)yrinic acid a,c-diamide;;(2b) a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)yrinic acid a,c-diamide = an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)yrinic acid a,c-diamide (spontaneous);;(2c) 2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)yrinic acid a,c-diamide = 2 triphosphate + 2 adenosylcob(III)yrinic acid a,c-diamide + 2 [corrinoid adenosyltransferase] | ATP:cob(II)alamin Cobeta-adenosyltransferase | None | MMAB (gene name); cobA (gene name); cobO (gene name); pduO (gene name); ATP:corrinoid adenosyltransferase; cob(I)alamin adenosyltransferase; aquacob(I)alamin adenosyltransferase; aquocob(I)alamin vitamin B12s adenosyltransferase; ATP:cob(I)alamin Cobeta-adenosyltransferase; ATP:cob(I)yrinic acid-a,c-diamide Cobeta-adenosyltransferase; cob(I)yrinic acid a,c-diamide adenosyltransferase | |
| 2.5.1.18 | glutathione transferase | False | 335 | 57870 | 471 | 176 | RX + glutathione = HX + R-S-glutathione | RX:glutathione R-transferase | None | glutathione S-transferase; glutathione S-alkyltransferase; glutathione S-aryltransferase; S-(hydroxyalkyl)glutathione lyase; glutathione S-aralkyltransferase; glutathione S-alkyl transferase; GST | |
| 2.5.1.19 | 3-phosphoshikimate 1-carboxyvinyltransferase | False | 650 | 44403 | 54 | 90 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate | phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase | None | 5-enolpyruvylshikimate-3-phosphate synthase; 3-enolpyruvylshikimate 5-phosphate synthase; 3-enolpyruvylshikimic acid-5-phosphate synthetase; 5'-enolpyruvylshikimate-3-phosphate synthase; 5-enolpyruvyl-3-phosphoshikimate synthase; 5-enolpyruvylshikimate-3-phosphate synthetase; 5-enolpyruvylshikimate-3-phosphoric acid synthase; enolpyruvylshikimate phosphate synthase; EPSP synthase | |
| 2.5.1.20 | rubber cis-polyprenylcistransferase | False | 1 | 3 | 0 | 18 | polycis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit | polycis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase | None | rubber allyltransferase; rubber transferase; isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase; cis-prenyl transferase; rubber polymerase; rubber prenyltransferase | |
| 2.5.1.21 | squalene synthase | False | 35 | 6910 | 42 | 49 | 2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ (overall reaction);;(1a) 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate;;(1b) presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+ | (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase | None | farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS | |
| 2.5.1.22 | spermine synthase | False | 7 | 30 | 3 | 16 | S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine | S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase | None | spermidine aminopropyltransferase; spermine synthetase; S-adenosylmethioninamine:spermidine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase | |
| 2.5.1.23 | sym-norspermidine synthase | False | 3 | 3 | 0 | 3 | S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine | S-adenosyl 3-(methylsulfanyl)propylamine:propane-1,3-diamine 3-aminopropyltransferase | None | S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:propane-1,3-diamine 3-aminopropyltransferase | |
| 2.5.1.24 | discadenine synthase | True | 0 | 0 | 0 | 3 | S-adenosyl-L-methionine + N6-(Delta2-isopentenyl)-adenine = S-methyl-5'-thioadenosine + discadenine | S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase | None | discadenine synthetase; S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase | |
| 2.5.1.25 | tRNA-uridine aminocarboxypropyltransferase | False | 13 | 12929 | 0 | 1 | S-adenosyl-L-methionine + a uridine in tRNA = S-methyl-5'-thioadenosine + a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA | S-adenosyl-L-methionine:uridine in tRNA 3-[(3S)-3-amino-3-carboxypropyl]transferase | None | S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase; tapT (gene name); DTWD1 (gene name); DTWD2 (gene name); S-adenosyl-L-methionine:uridine47 in tRNAPhe 3-[(3S)-3-amino-3-carboxypropyl]transferase | |
| 2.5.1.26 | alkylglycerone-phosphate synthase | False | 8 | 3443 | 10 | 12 | 1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion | 1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase | None | alkyldihydroxyacetonephosphate synthase; alkyldihydroxyacetone phosphate synthetase; alkyl DHAP synthetase; alkyl-DHAP; dihydroxyacetone-phosphate acyltransferase (ambiguous); DHAP-AT | |
| 2.5.1.27 | adenylate dimethylallyltransferase (AMP-dependent) | False | 18 | 150 | 5 | 15 | prenyl diphosphate + AMP = diphosphate + N6-prenyladenosine 5'-phosphate | prenyl-diphosphate:AMP prenyltransferase | None | cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:AMP Delta2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); IPT; adenylate dimethylallyltransferase; dimethylallyl-diphosphate:AMP dimethylallyltransferase | |
| 2.5.1.28 | dimethylallylcistransferase | False | 1 | 2 | 6 | 5 | prenyl diphosphate + 3-methyl-but-3-en-1-yl diphosphate = diphosphate + neryl diphosphate | prenyl-diphosphate:3-methyl-but-3-en-1-yl-diphosphate prenylcistransferase | None | neryl-diphosphate synthase; dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase | |
| 2.5.1.29 | geranylgeranyl diphosphate synthase | False | 99 | 2154 | 4 | 69 | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase | None | geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete) | |
| 2.5.1.30 | heptaprenyl diphosphate synthase | False | 4 | 1638 | 29 | 3 | (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units) | None | all-trans-heptaprenyl-diphosphate synthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase | |
| 2.5.1.31 | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | False | 43 | 7671 | 39 | 15 | (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units) | None | di-trans,poly-cis-undecaprenyl-diphosphate synthase; undecaprenyl-diphosphate synthase; bactoprenyl-diphosphate synthase; UPP synthetase; undecaprenyl diphosphate synthetase; undecaprenyl pyrophosphate synthetase; di-trans,poly-cis-decaprenylcistransferase | |
| 2.5.1.32 | 15-cis-phytoene synthase | False | 40 | 4436 | 1 | 52 | 2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate (overall reaction);;(1a) 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate;;(1b) prephytoene diphosphate = 15-cis-phytoene + diphosphate | geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (15-cis-phytoene-forming) | None | PSY (gene name); crtB (gene name); prephytoene-diphosphate synthase; phytoene synthetase; PSase; geranylgeranyl-diphosphate geranylgeranyltransferase | |
| 2.5.1.34 | 4-dimethylallyltryptophan synthase | False | 15 | 64 | 3 | 5 | prenyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-en-1-yl)-L-tryptophan | prenyl-diphosphate:L-tryptophan 4-prenyltransferase | None | dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase; dimethylallyltryptophan synthetase; dimethylallylpyrophosphate:tryptophan dimethylallyl transferase; DMAT synthetase; 4-(gamma,gamma-dimethylallyl)tryptophan synthase; tryptophan dimethylallyltransferase; dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase | |
| 2.5.1.35 | aspulvinone dimethylallyltransferase | False | 1 | 0 | 0 | 1 | 2 prenyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H | prenyl-diphosphate:aspulvinone-E prenyltransferase | None | dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase; dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase | |
| 2.5.1.36 | trihydroxypterocarpan dimethylallyltransferase | False | 1 | 1 | 0 | 1 | (1) prenyl diphosphate + (6aS,11aS)-3,6a,9-trihydroxypterocarpan = diphosphate + (6aS,11aS)-3,6a,9-trihydroxy-2-prenylpterocarpan;;(2) prenyl diphosphate + (6aS,11aS)-3,6a,9-trihydroxypterocarpan = diphosphate + (6aS,11aS)-3,6a,9-trihydroxy-4-prenylpterocarpan | prenyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan prenyltransferase | None | glyceollin synthase; dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase; dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase; dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase; dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase | |
| 2.5.1.38 | isonocardicin synthase | False | 1 | 2 | 0 | 1 | S-adenosyl-L-methionine + nocardicin G = S-methyl-5'-thioadenosine + isonocardicin C | S-adenosyl-L-methionine:nocardicin-G 3-amino-3-carboxypropyltransferase | None | nocardicin aminocarboxypropyltransferase; S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase | |
| 2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase | False | 244 | 18481 | 0 | 14 | a polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate | polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase | None | nonaprenyl-4-hydroxybenzoate transferase; 4-hydroxybenzoate transferase; p-hydroxybenzoate dimethylallyltransferase; p-hydroxybenzoate polyprenyltransferase; p-hydroxybenzoic acid-polyprenyl transferase; p-hydroxybenzoic-polyprenyl transferase; 4-hydroxybenzoate nonaprenyltransferase | |
| 2.5.1.41 | phosphoglycerol geranylgeranyltransferase | False | 66 | 5144 | 6 | 5 | geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate | geranylgeranyl-diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase | None | glycerol phosphate geranylgeranyltransferase; geranylgeranyl-transferase (ambiguous); prenyltransferase (ambiguous); (S)-3-O-geranylgeranylglyceryl phosphate synthase; (S)-geranylgeranylglyceryl phosphate synthase; GGGP synthase; (S)-GGGP synthase; GGGPS; geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase; geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase | |
| 2.5.1.42 | geranylgeranylglycerol-phosphate geranylgeranyltransferase | False | 40 | 1082 | 5 | 2 | geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate | geranylgeranyl-diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase | None | geranylgeranyloxyglycerol phosphate geranylgeranyltransferase; geranylgeranyltransferase II; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; DGGGP synthase; DGGGPS; geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase | |
| 2.5.1.43 | nicotianamine synthase | False | 19 | 1369 | 0 | 18 | 3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine | S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase | None | None | |
| 2.5.1.44 | homospermidine synthase | False | 2 | 417 | 17 | 12 | (1) 2 putrescine = sym-homospermidine + NH3;;(2) spermidine + putrescine = sym-homospermidine + propane-1,3-diamine | putrescine/spermidine:putrescine 4-aminobutyltransferase | None | putrescine:putrescine 4-aminobutyltransferase (ammonia-forming) | |
| 2.5.1.45 | homospermidine synthase (spermidine-specific) | False | 3 | 44 | 0 | 18 | spermidine + putrescine = sym-homospermidine + propane-1,3-diamine | spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming) | None | None | |
| 2.5.1.46 | deoxyhypusine synthase | False | 61 | 5219 | 22 | 37 | [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine (overall reaction);;(1a) spermidine + NAD+ = dehydrospermidine + NADH;;(1b) dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine;;(1c) N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine;;(1d) N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+ | [eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) | None | spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) | |
| 2.5.1.47 | cysteine synthase | False | 76 | 51418 | 83 | 74 | O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate | O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase | None | O-acetyl-L-serine sulfhydrylase; O-acetyl-L-serine sulfohydrolase; O-acetylserine (thiol)-lyase; O-acetylserine (thiol)-lyase A; O-acetylserine sulfhydrylase; O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide); acetylserine sulfhydrylase; cysteine synthetase; S-sulfocysteine synthase; 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase; O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase | |
| 2.5.1.48 | cystathionine gamma-synthase | False | 16 | 10317 | 6 | 35 | O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate | O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase | None | O-succinyl-L-homoserine succinate-lyase (adding cysteine); O-succinylhomoserine (thiol)-lyase; homoserine O-transsuccinylase (ambiguous); O-succinylhomoserine synthase; O-succinylhomoserine synthetase; cystathionine synthase; cystathionine synthetase; homoserine transsuccinylase (ambiguous); 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase | |
| 2.5.1.49 | O-acetylhomoserine aminocarboxypropyltransferase | False | 6 | 10734 | 1 | 17 | O-acetyl-L-homoserine + methanethiol = L-methionine + acetate | O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase | None | O-acetyl-L-homoserine acetate-lyase (adding methanethiol); O-acetyl-L-homoserine sulfhydrolase; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrolase; methionine synthase (misleading) | |
| 2.5.1.50 | zeatin 9-aminocarboxyethyltransferase | True | 0 | 0 | 0 | 1 | O-acetyl-L-serine + zeatin = lupinate + acetate | O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase | None | beta-(9-cytokinin)-alanine synthase; beta-(9-cytokinin)alanine synthase; O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine); lupinate synthetase; lupinic acid synthase; lupinic acid synthetase; 3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase | |
| 2.5.1.51 | beta-pyrazolylalanine synthase | False | 1 | 6 | 0 | 1 | O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate | O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase | None | beta-(1-pyrazolyl)alanine synthase; beta-pyrazolealanine synthase; beta-pyrazolylalanine synthase (acetylserine); O3-acetyl-L-serine acetate-lyase (adding pyrazole); BPA-synthase; pyrazolealanine synthase; pyrazolylalaninase; 3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase; O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase | |
| 2.5.1.52 | L-mimosine synthase | False | 1 | 2 | 0 | 1 | O-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate | O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase | None | O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl); 3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase; O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase | |
| 2.5.1.53 | uracilylalanine synthase | True | 0 | 0 | 0 | 5 | O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate | O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase | None | O3-acetyl-L-serine acetate-lyase (adding uracil); isowillardiine synthase; willardiine synthase; 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase; O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase | |
| 2.5.1.54 | 3-deoxy-7-phosphoheptulonate synthase | False | 48 | 57588 | 70 | 44 | phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate | phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) | None | 2-dehydro-3-deoxy-phosphoheptonate aldolase; 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase; 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase; 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase; 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating); 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating); D-erythrose-4-phosphate-lyase; D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating); DAH7-P synthase; DAHP synthase; DS-Co; DS-Mn; KDPH synthase; KDPH synthetase; deoxy-D-arabino-heptulosonate-7-phosphate synthetase; phospho-2-dehydro-3-deoxyheptonate aldolase; phospho-2-keto-3-deoxyheptanoate aldolase; phospho-2-keto-3-deoxyheptonate aldolase; phospho-2-keto-3-deoxyheptonic aldolase; phospho-2-oxo-3-deoxyheptonate aldolase | |
| 2.5.1.55 | 3-deoxy-8-phosphooctulonate synthase | False | 323 | 24440 | 58 | 44 | phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate | phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) | None | 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating); 2-dehydro-3-deoxy-phosphooctonate aldolase; 2-keto-3-deoxy-8-phosphooctonic synthetase; 3-deoxy-D-manno-octulosonate-8-phosphate synthase; 3-deoxy-D-mannooctulosonate-8-phosphate synthetase; 3-deoxyoctulosonic 8-phosphate synthetase; KDOP synthase; phospho-2-keto-3-deoxyoctonate aldolase | |
| 2.5.1.56 | N-acetylneuraminate synthase | False | 2 | 1928 | 7 | 9 | phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate | phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) | None | (NANA)condensing enzyme; N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating); NeuAc synthase | |
| 2.5.1.57 | N-acylneuraminate-9-phosphate synthase | False | 3 | 112 | 0 | 7 | phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate | phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase | None | N-acetylneuraminate 9-phosphate lyase; N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase; N-acetylneuraminate 9-phosphate synthetase; N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating); sialic acid 9-phosphate synthetase | |
| 2.5.1.58 | protein farnesyltransferase | False | 21 | 7510 | 54 | 24 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate | farnesyl-diphosphate:protein-cysteine farnesyltransferase | None | FTase | |
| 2.5.1.59 | protein geranylgeranyltransferase type I | False | 19 | 5719 | 5 | 17 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | None | GGTase-I; GGTaseI | |
| 2.5.1.60 | protein geranylgeranyltransferase type II | False | 23 | 7942 | 24 | 9 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | None | GGTaseII; Rab geranylgeranyltransferase; RabGGTase; geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | |
| 2.5.1.61 | hydroxymethylbilane synthase | False | 477 | 40099 | 23 | 23 | 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 | porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) | None | HMB-synthase; porphobilinogen deaminase; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase; uroporphyrinogen synthase; uroporphyrinogen synthetase; porphobilinogen ammonia-lyase (polymerizing); (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) | |
| 2.5.1.62 | chlorophyll synthase | False | 3 | 623 | 0 | 14 | chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate | chlorophyllide-a:phytyl-diphosphate phytyltransferase | None | None | |
| 2.5.1.63 | adenosyl-fluoride synthase | False | 5 | 39 | 16 | 6 | S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine | S-adenosyl-L-methionine:fluoride adenosyltransferase | None | fluorinase | |
| 2.5.1.65 | O-phosphoserine sulfhydrylase | False | 2 | 46 | 2 | 2 | O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate | O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase | None | O-phosphoserine(thiol)-lyase | |
| 2.5.1.66 | N2-(2-carboxyethyl)arginine synthase | False | 1 | 5 | 3 | 1 | D-glyceraldehyde 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate | glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) | None | CEAS; N2-(2-carboxyethyl)arginine synthetase; CEA synthetase; glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) | |
| 2.6.1.1 | aspartate transaminase | False | 91 | 22357 | 180 | 84 | L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate | L-aspartate:2-oxoglutarate aminotransferase | None | glutamic-oxaloacetic transaminase; glutamic-aspartic transaminase; transaminase A; AAT; AspT; 2-oxoglutarate-glutamate aminotransferase; aspartate alpha-ketoglutarate transaminase; aspartate aminotransferase; aspartate-2-oxoglutarate transaminase; aspartic acid aminotransferase; aspartic aminotransferase; aspartyl aminotransferase; AST (ambiguous); glutamate-oxalacetate aminotransferase; glutamate-oxalate transaminase; glutamic-aspartic aminotransferase; glutamic-oxalacetic transaminase; glutamic oxalic transaminase; GOT (enzyme) [ambiguous]; L-aspartate transaminase; L-aspartate-alpha-ketoglutarate transaminase; L-aspartate-2-ketoglutarate aminotransferase; L-aspartate-2-oxoglutarate aminotransferase; L-aspartate-2-oxoglutarate-transaminase; L-aspartic aminotransferase; oxaloacetate-aspartate aminotransferase; oxaloacetate transferase; aspartate:2-oxoglutarate aminotransferase; glutamate oxaloacetate transaminase | |
| 2.6.1.2 | alanine transaminase | False | 28 | 24242 | 3 | 48 | L-alanine + 2-oxoglutarate = pyruvate + L-glutamate | L-alanine:2-oxoglutarate aminotransferase | None | glutamic-pyruvic transaminase; glutamic-alanine transaminase; GPT (ambiguous); alanine aminotransferase; alanine-alpha-ketoglutarate aminotransferase; alanine-pyruvate aminotransferase; ALT; glutamic acid-pyruvic acid transaminase; glutamic-pyruvic aminotransferase; L-alanine aminotransferase; L-alanine transaminase; L-alanine-alpha-ketoglutarate aminotransferase; pyruvate transaminase; pyruvate-alanine aminotransferase; pyruvate-glutamate transaminase | |
| 2.6.1.3 | cysteine transaminase | False | 15 | 1 | 0 | 1 | L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate | L-cysteine:2-oxoglutarate aminotransferase | None | cysteine aminotransferase; L-cysteine aminotransferase; CGT | |
| 2.6.1.4 | glycine transaminase | False | 6 | 4 | 0 | 8 | glycine + 2-oxoglutarate = glyoxylate + L-glutamate | glycine:2-oxoglutarate aminotransferase | None | glutamic-glyoxylic transaminase; glycine aminotransferase; glyoxylate-glutamic transaminase; L-glutamate:glyoxylate aminotransferase; glyoxylate-glutamate aminotransferase | |
| 2.6.1.5 | tyrosine transaminase | False | 14 | 1917 | 4 | 26 | L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate | L-tyrosine:2-oxoglutarate aminotransferase | None | tyrosine aminotransferase; glutamic-hydroxyphenylpyruvic transaminase; glutamic phenylpyruvic aminotransferase; L-phenylalanine 2-oxoglutarate aminotransferase; L-tyrosine aminotransferase; phenylalanine aminotransferase; phenylalanine transaminase; phenylalanine-alpha-ketoglutarate transaminase; phenylpyruvate transaminase; phenylpyruvic acid transaminase; tyrosine-alpha-ketoglutarate aminotransferase; tyrosine-alpha-ketoglutarate transaminase; tyrosine-2-ketoglutarate aminotransferase; TyrAT | |
| 2.6.1.6 | leucine transaminase | False | 0 | 5 | 0 | 3 | L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate | L-leucine:2-oxoglutarate aminotransferase | None | L-leucine aminotransferase; leucine 2-oxoglutarate transaminase; leucine aminotransferase; leucine-alpha-ketoglutarate transaminase | |
| 2.6.1.7 | kynurenine---oxoglutarate transaminase | False | 28 | 2387 | 26 | 24 | L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O (overall reaction);;(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate;;(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) | L-kynurenine:2-oxoglutarate aminotransferase | None | kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase | |
| 2.6.1.9 | histidinol-phosphate transaminase | False | 505 | 48155 | 23 | 10 | L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate | L-histidinol-phosphate:2-oxoglutarate aminotransferase | None | imidazolylacetolphosphate transaminase; glutamic-imidazoleacetol phosphate transaminase; histidinol phosphate aminotransferase; imidazoleacetol phosphate transaminase; L-histidinol phosphate aminotransferase; histidine:imidazoleacetol phosphate transaminase; IAP transaminase; imidazolylacetolphosphate aminotransferase | |
| 2.6.1.11 | acetylornithine transaminase | False | 106 | 32064 | 23 | 11 | N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate | N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase | None | acetylornithine delta-transaminase; ACOAT; acetylornithine 5-aminotransferase; acetylornithine aminotransferase; N-acetylornithine aminotransferase; N-acetylornithine-delta-transaminase; N2-acetylornithine 5-transaminase; N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase; succinylornithine aminotransferase; 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase | |
| 2.6.1.12 | alanine---oxo-acid transaminase | False | 0 | 1 | 0 | 2 | L-alanine + a 2-oxo carboxylate = pyruvate + an L-amino acid | L-alanine:2-oxo-acid aminotransferase | None | L-alanine-alpha-keto acid aminotransferase; leucine-alanine transaminase; alanine-keto acid aminotransferase; alanine-oxo acid aminotransferase | |
| 2.6.1.13 | ornithine aminotransferase | False | 55 | 15397 | 37 | 42 | L-ornithine + a 2-oxo carboxylate = L-glutamate 5-semialdehyde + an L-amino acid | L-ornithine:2-oxo-acid aminotransferase | None | ornithine delta-transaminase; L-ornithine:alpha-ketoglutarate delta-aminotransferase; OAT; L-ornithine 5-aminotransferase; L-ornithine aminotransferase; ornithine 5-aminotransferase; ornithine transaminase; ornithine-alpha-ketoglutarate aminotransferase; ornithine-2-oxoacid aminotransferase; ornithine-keto acid aminotransferase; ornithine-keto acid transaminase; ornithine-ketoglutarate aminotransferase; ornithine-oxo acid aminotransferase; ornithine:alpha-oxoglutarate transaminase; ornithine---oxo-acid transaminase | |
| 2.6.1.14 | asparagine---oxo-acid transaminase | False | 1 | 6 | 0 | 4 | L-asparagine + a 2-oxo carboxylate = 2-oxosuccinamate + an amino acid | L-asparagine:2-oxo-acid aminotransferase | None | asparagine-keto acid aminotransferase | |
| 2.6.1.15 | glutamine---pyruvate transaminase | False | 0 | 4 | 3 | 4 | L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine | L-glutamine:pyruvate aminotransferase | None | glutaminase II; L-glutamine transaminase L; glutamine-oxo-acid transaminase | |
| 2.6.1.16 | glutamine---fructose-6-phosphate transaminase (isomerizing) | False | 173 | 61241 | 34 | 37 | L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate | L-glutamine:D-fructose-6-phosphate isomerase (deaminating) | None | hexosephosphate aminotransferase; glucosamine-6-phosphate isomerase (glutamine-forming); glutamine-fructose-6-phosphate transaminase (isomerizing); D-fructose-6-phosphate amidotransferase; glucosaminephosphate isomerase; glucosamine 6-phosphate synthase; GlcN6P synthase | |
| 2.6.1.17 | succinyldiaminopimelate transaminase | False | 12 | 6075 | 3 | 13 | N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate | N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase | None | succinyldiaminopimelate aminotransferase; N-succinyl-L-diaminopimelic glutamic transaminase | |
| 2.6.1.18 | beta-alanine---pyruvate transaminase | False | 8 | 3763 | 27 | 19 | L-alanine + 3-oxopropanoate = pyruvate + beta-alanine | L-alanine:3-oxopropanoate aminotransferase | None | beta-alanine-pyruvate aminotransferase; beta-alanine-alpha-alanine transaminase | |
| 2.6.1.19 | 4-aminobutyrate---2-oxoglutarate transaminase | False | 19 | 12058 | 23 | 33 | 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate | 4-aminobutanoate:2-oxoglutarate aminotransferase | None | beta-alanine-oxoglutarate transaminase; aminobutyrate aminotransferase (ambiguous); beta-alanine aminotransferase; beta-alanine-oxoglutarate aminotransferase; gamma-aminobutyrate aminotransaminase (ambiguous); gamma-aminobutyrate transaminase (ambiguous); gamma-aminobutyrate-alpha-ketoglutarate aminotransferase; gamma-aminobutyrate-alpha-ketoglutarate transaminase; gamma-aminobutyrate:alpha-oxoglutarate aminotransferase; gamma-aminobutyric acid aminotransferase (ambiguous); gamma-aminobutyric acid transaminase (ambiguous); gamma-aminobutyric acid-alpha-ketoglutarate transaminase; gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase; gamma-aminobutyric acid-2-oxoglutarate transaminase; gamma-aminobutyric transaminase (ambiguous); 4-aminobutyrate aminotransferase (ambiguous); 4-aminobutyrate-2-ketoglutarate aminotransferase; 4-aminobutyrate-2-oxoglutarate aminotransferase; 4-aminobutyrate-2-oxoglutarate transaminase; 4-aminobutyric acid 2-ketoglutaric acid aminotransferase; 4-aminobutyric acid aminotransferase (ambiguous); aminobutyrate transaminase (ambiguous); GABA aminotransferase (ambiguous); GABA transaminase (ambiguous); GABA transferase (ambiguous); GABA-alpha-ketoglutarate aminotransferase; GABA-alpha-ketoglutarate transaminase; GABA-alpha-ketoglutaric acid transaminase; GABA-alpha-oxoglutarate aminotransferase; GABA-2-oxoglutarate aminotransferase; GABA-2-oxoglutarate transaminase; GABA-oxoglutarate aminotransferase; GABA-oxoglutarate transaminase; glutamate-succinic semialdehyde transaminase; GabT | |
| 2.6.1.21 | D-amino-acid transaminase | False | 19 | 3260 | 10 | 17 | D-alanine + 2-oxoglutarate = pyruvate + D-glutamate | D-alanine:2-oxoglutarate aminotransferase | None | D-aspartate transaminase; D-alanine aminotransferase; D-aspartic aminotransferase; D-alanine-D-glutamate transaminase; D-alanine transaminase; D-amino acid aminotransferase | |
| 2.6.1.22 | (S)-3-amino-2-methylpropionate transaminase | False | 11 | 2015 | 0 | 2 | (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate | (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase | None | L-3-aminoisobutyrate transaminase; beta-aminobutyric transaminase; L-3-aminoisobutyric aminotransferase; beta-aminoisobutyrate-alpha-ketoglutarate transaminase | |
| 2.6.1.23 | 4-hydroxyglutamate transaminase | False | 0 | 2 | 0 | 1 | erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate | erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase | None | 4-hydroxyglutamate aminotransferase; 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase | |
| 2.6.1.24 | diiodotyrosine transaminase | True | 0 | 0 | 0 | 1 | 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate | 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase | None | diiodotyrosine aminotransferase; halogenated tyrosine aminotransferase; halogenated tyrosine transaminase | |
| 2.6.1.26 | thyroid-hormone transaminase | True | 0 | 0 | 0 | 1 | L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate | L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase | None | 3,5-dinitrotyrosine transaminase; thyroid hormone aminotransferase | |
| 2.6.1.27 | tryptophan transaminase | False | 6 | 13 | 0 | 15 | L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate | L-tryptophan:2-oxoglutarate aminotransferase | None | L-phenylalanine-2-oxoglutarate aminotransferase; tryptophan aminotransferase; 5-hydroxytryptophan-ketoglutaric transaminase; hydroxytryptophan aminotransferase; L-tryptophan aminotransferase; L-tryptophan transaminase | |
| 2.6.1.28 | tryptophan---phenylpyruvate transaminase | False | 1 | 0 | 0 | 3 | L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine | L-tryptophan:phenylpyruvate aminotransferase | None | L-tryptophan-alpha-ketoisocaproate aminotransferase | |
| 2.6.1.29 | diamine transaminase | False | 47 | 1072 | 0 | 16 | an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate | diamine:2-oxoglutarate aminotransferase | None | amine transaminase; amine-ketoacid transaminase; diamine aminotransferase; diamine-ketoglutaric transaminase | |
| 2.6.1.30 | pyridoxamine---pyruvate transaminase | False | 1 | 26 | 4 | 6 | pyridoxamine + pyruvate = pyridoxal + L-alanine | pyridoxamine:pyruvate aminotransferase | None | pyridoxamine-pyruvic transaminase | |
| 2.6.1.31 | pyridoxamine---oxaloacetate transaminase | True | 0 | 0 | 0 | 3 | pyridoxamine + oxaloacetate = pyridoxal + L-aspartate | pyridoxamine:oxaloacetate aminotransferase | None | None | |
| 2.6.1.32 | valine---3-methyl-2-oxovalerate transaminase | True | 0 | 0 | 0 | 2 | L-valine + (S)-3-methyl-2-oxopentanoate = 3-methyl-2-oxobutanoate + L-isoleucine | L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase | None | valine---isoleucine transaminase; valine-3-methyl-2-oxovalerate aminotransferase; alanine-valine transaminase; valine-2-keto-methylvalerate aminotransferase; valine-isoleucine aminotransferase | |
| 2.6.1.33 | dTDP-4-amino-4,6-dideoxy-D-glucose transaminase | False | 2 | 247 | 0 | 3 | dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate | dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase | None | thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase; thymidine diphospho-4-amino-6-deoxyglucose aminotransferase; thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase; thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase; TDP-4-keto-6-deoxy-D-glucose transaminase; VioA; dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase | |
| 2.6.1.34 | UDP-N-acetylbacillosamine transaminase | False | 1 | 137 | 0 | 2 | UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate | UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase | None | uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase; UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase; UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase; pglE (gene name); UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase | |
| 2.6.1.35 | glycine---oxaloacetate transaminase | False | 1 | 0 | 0 | 3 | glycine + oxaloacetate = glyoxylate + L-aspartate | glycine:oxaloacetate aminotransferase | None | glycine-oxalacetate aminotransferase | |
| 2.6.1.36 | L-lysine 6-transaminase | False | 6 | 2204 | 8 | 7 | L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate | L-lysine:2-oxoglutarate 6-aminotransferase | None | lysine 6-aminotransferase; lysine epsilon-aminotransferase; lysine epsilon-transaminase; lysine:2-ketoglutarate 6-aminotransferase; L-lysine-alpha-ketoglutarate aminotransferase; L-lysine-alpha-ketoglutarate 6-aminotransferase | |
| 2.6.1.37 | 2-aminoethylphosphonate---pyruvate transaminase | False | 82 | 6237 | 2 | 3 | (2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine | (2-aminoethyl)phosphonate:pyruvate aminotransferase | None | (2-aminoethyl)phosphonate transaminase; (2-aminoethyl)phosphonate aminotransferase; (2-aminoethyl)phosphonic acid aminotransferase; 2-aminoethylphosphonate-pyruvate aminotransferase; 2-aminoethylphosphonate aminotransferase; 2-aminoethylphosphonate transaminase; AEP transaminase; AEPT | |
| 2.6.1.38 | histidine transaminase | False | 1 | 0 | 0 | 5 | L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate | L-histidine:2-oxoglutarate aminotransferase | None | histidine aminotransferase; histidine-2-oxoglutarate aminotransferase | |
| 2.6.1.39 | 2-aminoadipate transaminase | False | 8 | 1587 | 19 | 7 | L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate | L-2-aminoadipate:2-oxoglutarate aminotransferase | None | alpha-aminoadipate aminotransferase; 2-aminoadipate aminotransferase; 2-aminoadipic aminotransferase; glutamic-ketoadipic transaminase; glutamate-alpha-ketoadipate transaminase | |
| 2.6.1.40 | (R)-3-amino-2-methylpropionate---pyruvate transaminase | False | 5 | 1184 | 0 | 4 | (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine | (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase | None | D-3-aminoisobutyrate---pyruvate transaminase; beta-aminoisobutyrate-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate transaminase; (R)-3-amino-2-methylpropionate transaminase; D-beta-aminoisobutyrate:pyruvate aminotransferase | |
| 2.6.1.41 | D-methionine---pyruvate transaminase | True | 0 | 0 | 0 | 2 | D-methionine + pyruvate = 4-(methylsulfanyl)-2-oxobutanoate + L-alanine | D-methionine:pyruvate aminotransferase | None | D-methionine transaminase; D-methionine aminotransferase | |
| 2.6.1.42 | branched-chain-amino-acid transaminase | False | 60 | 59133 | 86 | 51 | L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate | branched-chain-amino-acid:2-oxoglutarate aminotransferase | None | transaminase B; branched-chain amino acid aminotransferase; branched-chain amino acid-glutamate transaminase; branched-chain aminotransferase; L-branched chain amino acid aminotransferase; glutamate-branched-chain amino acid transaminase | |
| 2.6.1.43 | aminolevulinate transaminase | True | 0 | 0 | 0 | 14 | 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine | 5-aminolevulinate:pyruvate aminotransferase | None | aminolevulinate aminotransferase; gamma,delta-dioxovalerate aminotransferase; gamma,delta-dioxovaleric acid transaminase; 4,5-dioxovalerate aminotransferase; 4,5-dioxovaleric acid transaminase; 4,5-dioxovaleric transaminase; 5-aminolevulinic acid transaminase; alanine-gamma,delta-dioxovalerate aminotransferase; alanine-dioxovalerate aminotransferase; alanine:4,5-dioxovalerate aminotransferase; aminolevulinic acid transaminase; dioxovalerate transaminase; L-alanine-4,5-dioxovalerate aminotransferase; L-alanine:4,5-dioxovaleric acid transaminase; L-alanine:dioxovalerate transaminase; DOVA transaminase; 4,5-dioxovaleric acid aminotransferase | |
| 2.6.1.44 | alanine---glyoxylate transaminase | False | 26 | 5299 | 11 | 51 | L-alanine + glyoxylate = pyruvate + glycine | L-alanine:glyoxylate aminotransferase | None | AGT; alanine-glyoxylate aminotransferase; alanine-glyoxylic aminotransferase; L-alanine-glycine transaminase | |
| 2.6.1.45 | serine---glyoxylate transaminase | False | 5 | 735 | 2 | 22 | L-serine + glyoxylate = 3-hydroxypyruvate + glycine | L-serine:glyoxylate aminotransferase | None | None | |
| 2.6.1.46 | diaminobutyrate---pyruvate transaminase | False | 0 | 27 | 0 | 5 | L-2,4-diaminobutanoate + pyruvate = L-aspartate 4-semialdehyde + L-alanine | L-2,4-diaminobutanoate:pyruvate aminotransferase | None | diaminobutyrate-pyruvate aminotransferase; L-diaminobutyric acid transaminase | |
| 2.6.1.47 | alanine---oxomalonate transaminase | True | 0 | 0 | 0 | 3 | L-alanine + oxomalonate = pyruvate + aminomalonate | L-alanine:oxomalonate aminotransferase | None | alanine-oxomalonate aminotransferase; L-alanine-ketomalonate transaminase; alanine-ketomalonate (mesoxalate) transaminase | |
| 2.6.1.48 | 5-aminovalerate transaminase | False | 3 | 483 | 0 | 10 | 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate | 5-aminopentanoate:2-oxoglutarate aminotransferase | None | 5-aminovalerate aminotransferase; delta-aminovalerate aminotransferase; delta-aminovalerate transaminase | |
| 2.6.1.49 | dihydroxyphenylalanine transaminase | False | 0 | 2 | 0 | 5 | L-dopa + 2-oxoglutarate = 3,4-dihydroxyphenylpyruvate + L-glutamate | 3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase | None | dopa transaminase; dihydroxyphenylalanine aminotransferase; aspartate-DOPP transaminase (ADT); L-dopa transaminase; dopa aminotransferase; glutamate-DOPP transaminase (GDT); phenylalanine-DOPP transaminase (PDT); DOPA 2-oxoglutarate aminotransferase; DOPAATS | |
| 2.6.1.50 | glutamine---scyllo-inositol transaminase | False | 1 | 533 | 1 | 12 | L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone = 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase | None | glutamine scyllo-inosose aminotransferase; L-glutamine-keto-scyllo-inositol aminotransferase; glutamine-scyllo-inosose transaminase; L-glutamine-scyllo-inosose transaminase | |
| 2.6.1.51 | serine---pyruvate transaminase | False | 10 | 1798 | 15 | 12 | L-serine + pyruvate = 3-hydroxypyruvate + L-alanine | L-serine:pyruvate aminotransferase | None | SPT; hydroxypyruvate:L-alanine transaminase | |
| 2.6.1.52 | phosphoserine transaminase | False | 273 | 35364 | 35 | 21 | (1) O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate;;(2) 4-phosphooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate | O-phospho-L-serine:2-oxoglutarate aminotransferase | None | PSAT; phosphoserine aminotransferase; 3-phosphoserine aminotransferase; hydroxypyruvic phosphate-glutamic transaminase; L-phosphoserine aminotransferase; phosphohydroxypyruvate transaminase; phosphohydroxypyruvic-glutamic transaminase; 3-O-phospho-L-serine:2-oxoglutarate aminotransferase; SerC; PdxC; 3PHP transaminase | |
| 2.6.1.54 | pyridoxamine-phosphate transaminase | False | 0 | 36 | 0 | 1 | pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate | pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming) | None | pyridoxamine phosphate aminotransferase; pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase; pyridoxamine 5'-phosphate transaminase | |
| 2.6.1.55 | taurine---2-oxoglutarate transaminase | False | 0 | 176 | 0 | 3 | taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate | taurine:2-oxoglutarate aminotransferase | None | taurine aminotransferase; taurine transaminase; taurine---alpha-ketoglutarate aminotransferase; taurine---glutamate transaminase | |
| 2.6.1.56 | 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase | True | 0 | 0 | 0 | 3 | 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine | 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase | None | guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase; L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase | |
| 2.6.1.57 | aromatic-amino-acid transaminase | False | 14 | 1130 | 19 | 38 | an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate | aromatic-amino-acid:2-oxoglutarate aminotransferase | None | aromatic amino acid aminotransferase; aromatic aminotransferase; ArAT | |
| 2.6.1.58 | phenylalanine(histidine) transaminase | True | 0 | 0 | 0 | 8 | L-phenylalanine + pyruvate = phenylpyruvate + L-alanine | L-phenylalanine:pyruvate aminotransferase | None | phenylalanine (histidine) aminotransferase; phenylalanine(histidine):pyruvate aminotransferase; histidine:pyruvate aminotransferase; L-phenylalanine(L-histidine):pyruvate aminotransferase | |
| 2.6.1.59 | dTDP-4-amino-4,6-dideoxygalactose transaminase | False | 1 | 2972 | 2 | 2 | dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-galactose + L-glutamate | dTDP-4-amino-4,6-dideoxy-alpha-D-galactose:2-oxoglutarate aminotransferase | None | thymidine diphosphoaminodideoxygalactose aminotransferase; thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase; WecE; dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase; dTDP-4,6-dideoxy-alpha-D-galactose:2-oxoglutarate aminotransferase | |
| 2.6.1.60 | aromatic-amino-acid---glyoxylate transaminase | True | 0 | 0 | 0 | 3 | an aromatic amino acid + glyoxylate = an aromatic oxo acid + glycine | aromatic-amino-acid:glyoxylate aminotransferase | None | None | |
| 2.6.1.62 | adenosylmethionine---8-amino-7-oxononanoate transaminase | False | 34 | 20813 | 49 | 9 | S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate | S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase | None | 7,8-diaminonanoate transaminase; 7,8-diaminononanoate transaminase; DAPA transaminase (ambiguous); 7,8-diaminopelargonic acid aminotransferase; DAPA aminotransferase (ambiguous); 7-keto-8-aminopelargonic acid; diaminopelargonate synthase; 7-keto-8-aminopelargonic acid aminotransferase | |
| 2.6.1.63 | kynurenine---glyoxylate transaminase | False | 12 | 1174 | 0 | 3 | (1) L-kynurenine + glyoxylate = kynurenate + glycine + H2O (overall reaction);;(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine;;(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous);;(2) 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O (overall reaction);;(2a) 3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine;;(2b) 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O (spontaneous) | L-kynurenine:glyoxylate aminotransferase (cyclizing) | None | kynurenine-glyoxylate aminotransferase | |
| 2.6.1.64 | glutamine---phenylpyruvate transaminase | False | 4 | 11 | 0 | 7 | L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine | L-glutamine:phenylpyruvate aminotransferase | None | glutamine transaminase K; glutamine-phenylpyruvate aminotransferase | |
| 2.6.1.65 | N6-acetyl-beta-lysine transaminase | True | 0 | 0 | 0 | 1 | 6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate | 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase | None | epsilon-acetyl-beta-lysine aminotransferase | |
| 2.6.1.66 | valine---pyruvate transaminase | False | 2 | 2185 | 1 | 3 | L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine | L-valine:pyruvate aminotransferase | None | transaminase C; valine-pyruvate aminotransferase; alanine-oxoisovalerate aminotransferase | |
| 2.6.1.67 | 2-aminohexanoate transaminase | True | 0 | 0 | 0 | 1 | L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate | L-2-aminohexanoate:2-oxoglutarate aminotransferase | None | norleucine transaminase; norleucine (leucine) aminotransferase; leucine L-norleucine: 2-oxoglutarate aminotransferase | |
| 2.6.1.70 | aspartate---phenylpyruvate transaminase | True | 0 | 0 | 0 | 1 | L-aspartate + phenylpyruvate = oxaloacetate + L-phenylalanine | L-aspartate:phenylpyruvate aminotransferase | None | aspartate-phenylpyruvate aminotransferase | |
| 2.6.1.71 | lysine---pyruvate 6-transaminase | True | 0 | 0 | 0 | 2 | L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine | L-lysine:pyruvate aminotransferase | None | lysine-pyruvate aminotransferase; Lys-AT | |
| 2.6.1.72 | D-4-hydroxyphenylglycine transaminase | False | 0 | 0 | 1 | 2 | D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate | D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase | None | D-hydroxyphenylglycine aminotransferase | |
| 2.6.1.73 | methionine---glyoxylate transaminase | False | 4 | 0 | 0 | 2 | L-methionine + glyoxylate = 4-(methylsulfanyl)-2-oxobutanoate + glycine | L-methionine:glyoxylate aminotransferase | None | methionine-glyoxylate aminotransferase; MGAT | |
| 2.6.1.74 | cephalosporin-C transaminase | True | 0 | 0 | 0 | 1 | (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate | cephalosporin-C:2-oxoglutarate aminotransferase | None | cephalosporin C aminotransferase; L-alanine:cephalosporin-C aminotransferase | |
| 2.6.1.75 | cysteine-conjugate transaminase | True | 0 | 0 | 0 | 1 | S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = 3-[(4-bromophenyl)sulfanyl]-2-oxopropanoate + L-glutamate | S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase | None | cysteine conjugate aminotransferase; cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1) | |
| 2.6.1.76 | diaminobutyrate---2-oxoglutarate transaminase | False | 21 | 6978 | 1 | 12 | L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate | L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase | None | L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; 2,4-diaminobutyrate 4-aminotransferase; diaminobutyrate aminotransferase; DABA aminotransferase; DAB aminotransferase; EctB; diaminibutyric acid aminotransferase; L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase | |
| 2.6.1.77 | taurine---pyruvate aminotransferase | False | 4 | 738 | 0 | 13 | taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde | taurine:pyruvate aminotransferase | None | Tpa | |
| 2.6.1.78 | aspartate---prephenate aminotransferase | False | 6 | 8 | 0 | 5 | L-arogenate + oxaloacetate = prephenate + L-aspartate | L-arogenate:oxaloacetate aminotransferase | None | prephenate transaminase (ambiguous); PAT (ambiguous); prephenate aspartate aminotransferase; L-aspartate:prephenate aminotransferase | |
| 2.6.1.79 | glutamate---prephenate aminotransferase | False | 11 | 15 | 0 | 13 | L-arogenate + 2-oxoglutarate = prephenate + L-glutamate | L-arogenate:2-oxoglutarate aminotransferase | None | prephenate transaminase (ambiguous); PAT (ambiguous); L-glutamate:prephenate aminotransferase | |
| 2.6.1.80 | nicotianamine aminotransferase | False | 3 | 3 | 0 | 3 | nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate | nicotianamine:2-oxoglutarate aminotransferase | None | NAAT; NAAT-I; NAAT-II; NAAT-III; nicotianamine transaminase | |
| 2.6.3.1 | oximinotransferase | True | 0 | 0 | 0 | 3 | pyruvate oxime + acetone = pyruvate + acetone oxime | pyruvate-oxime:acetone oximinotransferase | None | transoximinase; oximase; pyruvate-acetone oximinotransferase; transoximase | |
| 2.6.99.1 | dATP(dGTP)---DNA purinetransferase | True | 0 | 0 | 0 | 2 | (1) dATP + depurinated DNA = deoxyribose triphosphate + DNA;; (2) dGTP + depurinated DNA = deoxyribose triphosphate + DNA | dATP(dGTP):depurinated-DNA purine transferase | None | None | |
| 2.7.1.1 | hexokinase | False | 59 | 5301 | 50 | 75 | ATP + D-hexose = ADP + D-hexose 6-phosphate | ATP:D-hexose 6-phosphotransferase | None | hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase | |
| 2.7.1.2 | glucokinase | False | 157 | 22604 | 57 | 31 | ATP + D-glucose = ADP + D-glucose 6-phosphate | ATP:D-glucose 6-phosphotransferase | None | glucokinase (phosphorylating) | |
| 2.7.1.3 | ketohexokinase | False | 4 | 46 | 30 | 10 | ATP + D-fructose = ADP + D-fructose 1-phosphate | ATP:D-fructose 1-phosphotransferase | None | ketohexokinase (phosphorylating) | |
| 2.7.1.4 | fructokinase | False | 31 | 10184 | 21 | 46 | ATP + D-fructose = ADP + D-fructose 6-phosphate | ATP:D-fructose 6-phosphotransferase | None | fructokinase (phosphorylating); D-fructokinase; D-fructose(D-mannose)kinase | |
| 2.7.1.5 | rhamnulokinase | False | 65 | 3608 | 4 | 4 | ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate | ATP:L-rhamnulose 1-phosphotransferase | None | RhuK; rhamnulokinase (phosphorylating); L-rhamnulokinase; L-rhamnulose kinase; rhamnulose kinase | |
| 2.7.1.6 | galactokinase | False | 146 | 21285 | 26 | 26 | ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate | ATP:alpha-D-galactose 1-phosphotransferase | None | galactokinase (phosphorylating); ATP:D-galactose-1-phosphotransferase | |
| 2.7.1.7 | mannokinase | False | 1 | 13 | 0 | 6 | ATP + D-mannose = ADP + D-mannose 6-phosphate | ATP:D-mannose 6-phosphotransferase | None | mannokinase (phosphorylating); D-fructose (D-mannose) kinase | |
| 2.7.1.8 | glucosamine kinase | False | 3 | 585 | 0 | 5 | ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate | ATP:D-glucosamine 6-phosphotransferase | None | glucosamine kinase (phosphorylating); ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase; aminodeoxyglucose kinase; ATP:D-glucosamine phosphotransferase | |
| 2.7.1.10 | phosphoglucokinase | False | 0 | 1 | 0 | 3 | ATP + alpha-D-glucose 1-phosphate = ADP + alpha-D-glucose 1,6-bisphosphate | ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase | None | glucose-phosphate kinase; phosphoglucokinase (phosphorylating); ATP:D-glucose-1-phosphate 6-phosphotransferase | |
| 2.7.1.11 | 6-phosphofructokinase | False | 336 | 40294 | 43 | 97 | ATP + beta-D-fructofuranose 6-phosphate = ADP + beta-D-fructofuranose 1,6-bisphosphate | ATP:beta-D-fructose-6-phosphate 1-phosphotransferase | None | phosphohexokinase; phosphofructokinase I; phosphofructokinase (phosphorylating); 6-phosphofructose 1-kinase; ATP-dependent phosphofructokinase; D-fructose-6-phosphate 1-phosphotransferase; fructose 6-phosphate kinase; fructose 6-phosphokinase; nucleotide triphosphate-dependent phosphofructokinase; phospho-1,6-fructokinase; PFK | |
| 2.7.1.12 | gluconokinase | False | 13 | 19207 | 10 | 15 | ATP + D-gluconate = ADP + 6-phospho-D-gluconate | ATP:D-gluconate 6-phosphotransferase | None | gluconokinase (phosphorylating); gluconate kinase | |
| 2.7.1.13 | dehydrogluconokinase | False | 0 | 43 | 0 | 3 | ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate | ATP:2-dehydro-D-gluconate 6-phosphotransferase | None | ketogluconokinase; 2-ketogluconate kinase; ketogluconokinase (phosphorylating); 2-ketogluconokinase | |
| 2.7.1.14 | sedoheptulokinase | False | 2 | 17 | 0 | 4 | ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate | ATP:sedoheptulose 7-phosphotransferase | None | heptulokinase; sedoheptulokinase (phosphorylating) | |
| 2.7.1.15 | ribokinase | False | 18 | 31872 | 36 | 21 | ATP + D-ribose = ADP + D-ribose 5-phosphate | ATP:D-ribose 5-phosphotransferase | None | deoxyribokinase; ribokinase (phosphorylating); D-ribokinase | |
| 2.7.1.16 | ribulokinase | False | 77 | 6764 | 1 | 6 | ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate | ATP:L(or D)-ribulose 5-phosphotransferase | None | ribulokinase (phosphorylating); L-ribulokinase | |
| 2.7.1.17 | xylulokinase | False | 34 | 21724 | 11 | 22 | ATP + D-xylulose = ADP + D-xylulose 5-phosphate | ATP:D-xylulose 5-phosphotransferase | None | xylulokinase (phosphorylating); D-xylulokinase | |
| 2.7.1.18 | phosphoribokinase | True | 0 | 0 | 0 | 2 | ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate | ATP:D-ribose-5-phosphate 1-phosphotransferase | None | phosphoribokinase (phosphorylating) | |
| 2.7.1.19 | phosphoribulokinase | False | 20 | 8457 | 9 | 58 | ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate | ATP:D-ribulose-5-phosphate 1-phosphotransferase | None | phosphopentokinase; ribulose-5-phosphate kinase; phosphopentokinase; phosphoribulokinase (phosphorylating); 5-phosphoribulose kinase; ribulose phosphate kinase; PKK; PRuK; PRK | |
| 2.7.1.20 | adenosine kinase | False | 17 | 7582 | 39 | 39 | ATP + adenosine = ADP + AMP | ATP:adenosine 5'-phosphotransferase | None | adenosine kinase (phosphorylating) | |
| 2.7.1.21 | thymidine kinase | False | 256 | 25880 | 60 | 59 | ATP + thymidine = ADP + dTMP | ATP:thymidine 5'-phosphotransferase | None | thymidine kinase (phosphorylating); 2'-deoxythymidine kinase; deoxythymidine kinase (phosphorylating) | |
| 2.7.1.22 | ribosylnicotinamide kinase | False | 12 | 972 | 1 | 8 | ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide | ATP:1-(beta-D-ribofuranosyl)-nicotinamide 5'-phosphotransferase | None | ribosylnicotinamide kinase (phosphorylating); ATP:N-ribosylnicotinamide 5'-phosphotransferase | |
| 2.7.1.23 | NAD+ kinase | False | 540 | 46079 | 94 | 53 | ATP + NAD+ = ADP + NADP+ | ATP:NAD+ 2'-phosphotransferase | None | DPN kinase; nicotinamide adenine dinucleotide kinase (phosphorylating); nicotinamide adenine dinucleotide kinase; NAD kinase; NADK | |
| 2.7.1.24 | dephospho-CoA kinase | False | 271 | 40094 | 23 | 18 | ATP + 3'-dephospho-CoA = ADP + CoA | ATP:3'-dephospho-CoA 3'-phosphotransferase | None | dephosphocoenzyme A kinase (phosphorylating); 3'-dephospho-CoA kinase; dephosphocoenzyme A kinase; ATP:dephospho-CoA 3'-phosphotransferase | |
| 2.7.1.25 | adenylyl-sulfate kinase | False | 155 | 28512 | 19 | 29 | ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate | ATP:adenylyl-sulfate 3'-phosphotransferase | None | adenylylsulfate kinase (phosphorylating); 5'-phosphoadenosine sulfate kinase; adenosine 5'-phosphosulfate kinase; adenosine phosphosulfate kinase; adenosine phosphosulfokinase; adenosine-5'-phosphosulfate-3'-phosphokinase; APS kinase | |
| 2.7.1.26 | riboflavin kinase | False | 41 | 45213 | 18 | 14 | ATP + riboflavin = ADP + FMN | ATP:riboflavin 5'-phosphotransferase | None | flavokinase; FK; RFK | |
| 2.7.1.27 | erythritol kinase (D-erythritol 4-phosphate-forming) | False | 0 | 109 | 1 | 2 | ATP + erythritol = ADP + D-erythritol 4-phosphate | ATP:erythritol 4-phosphotransferase | None | erythritol kinase (phosphorylating) (ambiguous) | |
| 2.7.1.28 | triokinase | False | 12 | 1468 | 0 | 4 | ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate | ATP:D-glyceraldehyde 3-phosphotransferase | None | triose kinase; | |
| 2.7.1.29 | glycerone kinase | False | 13 | 2665 | 6 | 20 | ATP + glycerone = ADP + glycerone phosphate | ATP:glycerone phosphotransferase | None | dihydroxyacetone kinase; acetol kinase; acetol kinase (phosphorylating) | |
| 2.7.1.30 | glycerol kinase | False | 443 | 36791 | 41 | 69 | ATP + glycerol = ADP + sn-glycerol 3-phosphate | ATP:glycerol 3-phosphotransferase | None | glycerokinase; GK; ATP:glycerol-3-phosphotransferase; glycerol kinase (phosphorylating); glyceric kinase | |
| 2.7.1.31 | glycerate 3-kinase | False | 15 | 4651 | 4 | 17 | ATP + D-glycerate = ADP + 3-phospho-D-glycerate | ATP:D-glycerate 3-phosphotransferase | None | glycerate kinase (phosphorylating) (ambiguous); D-glycerate 3-kinase; D-glycerate kinase (ambiguous); glycerate-kinase (ambiguous); GK (ambiguous); D-glyceric acid kinase (ambiguous); ATP:(R)-glycerate 3-phosphotransferase | |
| 2.7.1.32 | choline kinase | False | 15 | 176 | 35 | 35 | ATP + choline = ADP + phosphocholine | ATP:choline phosphotransferase | None | choline kinase (phosphorylating); choline phosphokinase; choline-ethanolamine kinase | |
| 2.7.1.33 | pantothenate kinase | False | 640 | 43342 | 96 | 32 | ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate | ATP:(R)-pantothenate 4'-phosphotransferase | None | pantothenate kinase (phosphorylating); pantothenic acid kinase; ATP:pantothenate 4'-phosphotransferase; D-pantothenate kinase | |
| 2.7.1.34 | pantetheine kinase | True | 0 | 0 | 0 | 3 | ATP + pantetheine = ADP + pantetheine 4'-phosphate | ATP:pantetheine 4'-phosphotransferase | None | pantetheine kinase (phosphorylating) | |
| 2.7.1.35 | pyridoxal kinase | False | 118 | 18654 | 45 | 30 | ATP + pyridoxal = ADP + pyridoxal 5'-phosphate | ATP:pyridoxal 5'-phosphotransferase | None | pyridoxal kinase (phosphorylating); pyridoxal 5-phosphate-kinase; pyridoxal phosphokinase; pyridoxine kinase | |
| 2.7.1.36 | mevalonate kinase | False | 23 | 8991 | 11 | 38 | ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate | ATP:(R)-mevalonate 5-phosphotransferase | None | mevalonate kinase (phosphorylating); mevalonate phosphokinase; mevalonic acid kinase; mevalonic kinase; mevalonate 5-phosphotransferase ; MVA kinase; ATP:mevalonate 5-phosphotransferase | |
| 2.7.1.39 | homoserine kinase | False | 439 | 30878 | 12 | 17 | ATP + L-homoserine = ADP + O-phospho-L-homoserine | ATP:L-homoserine O-phosphotransferase | None | homoserine kinase (phosphorylating); HSK | |
| 2.7.1.40 | pyruvate kinase | False | 111 | 64776 | 188 | 138 | ATP + pyruvate = ADP + phosphoenolpyruvate | ATP:pyruvate 2-O-phosphotransferase | None | phosphoenolpyruvate kinase; phosphoenol transphosphorylase | |
| 2.7.1.41 | glucose-1-phosphate phosphodismutase | False | 0 | 22 | 0 | 4 | 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate | D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase | None | None | |
| 2.7.1.42 | riboflavin phosphotransferase | True | 0 | 0 | 0 | 1 | alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN | alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase | None | riboflavine phosphotransferase; glucose-1-phosphate phosphotransferase; G-1-P phosphotransferase; D-glucose-1-phosphate:riboflavin 5'-phosphotransferase | |
| 2.7.1.43 | glucuronokinase | False | 2 | 21 | 0 | 7 | ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate | ATP:D-glucuronate 1-phosphotransferase | None | glucuronokinase (phosphorylating); glucurono-glucuronokinase | |
| 2.7.1.44 | galacturonokinase | False | 1 | 6 | 0 | 6 | ATP + D-galacturonate = ADP + 1-phospho-alpha-D-galacturonate | ATP:D-galacturonate 1-phosphotransferase | None | galacturonokinase (phosphorylating) D-galacturonic acid kinase | |
| 2.7.1.45 | 2-dehydro-3-deoxygluconokinase | False | 10 | 2168 | 5 | 9 | ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate | ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase | None | 2-keto-3-deoxygluconokinase; 2-keto-3-deoxy-D-gluconic acid kinase; 2-keto-3-deoxygluconokinase (phosphorylating); 2-keto-3-deoxygluconate kinase; ketodeoxygluconokinase | |
| 2.7.1.46 | L-arabinokinase | False | 1 | 20 | 0 | 3 | ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate | ATP:L-arabinose 1-phosphotransferase | None | L-arabinokinase (phosphorylating) | |
| 2.7.1.47 | D-ribulokinase | False | 5 | 107 | 0 | 3 | ATP + D-ribulose = ADP + D-ribulose 5-phosphate | ATP:D-ribulose 5-phosphotransferase | None | D-ribulokinase (phosphorylating) | |
| 2.7.1.48 | uridine/cytidine kinase | False | 236 | 22896 | 17 | 11 | (1) ATP + uridine = ADP + UMP;;(2) ATP + cytidine = ADP + CMP | ATP:uridine/cytidine 5'-phosphotransferase | None | UCK (gene name); URK1 (gene name); pyrimidine ribonucleoside kinase; uridine-cytidine kinase; uridine kinase (phosphorylating); uridine phosphokinase; ATP:uridine 5'-phosphotransferase; uridine kinase | |
| 2.7.1.49 | hydroxymethylpyrimidine kinase | False | 33 | 29774 | 2 | 12 | ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine | ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase | None | hydroxymethylpyrimidine kinase (phosphorylating) | |
| 2.7.1.50 | hydroxyethylthiazole kinase | False | 320 | 12640 | 12 | 8 | ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole | ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase | None | hydroxyethylthiazole kinase (phosphorylating); 4-methyl-5-(beta-hydroxyethyl)thiazole kinase | |
| 2.7.1.51 | L-fuculokinase | False | 5 | 1454 | 1 | 4 | ATP + L-fuculose = ADP + L-fuculose 1-phosphate | ATP:L-fuculose 1-phosphotransferase | None | L-fuculokinase (phosphorylating); L-fuculose kinase | |
| 2.7.1.52 | fucokinase | False | 3 | 42 | 0 | 22 | ATP + L-fucose = ADP + beta-L-fucose 1-phosphate | ATP:beta-L-fucose 1-phosphotransferase | None | fucokinase (phosphorylating); fucose kinase; L-fucose kinase; L-fucokinase; ATP:6-deoxy-L-galactose 1-phosphotransferase; ATP:L-fucose 1-phosphotransferase | |
| 2.7.1.53 | L-xylulokinase | False | 3 | 311 | 0 | 3 | ATP + L-xylulose = ADP + L-xylulose 5-phosphate | ATP:L-xylulose 5-phosphotransferase | None | L-xylulokinase (phosphorylating) | |
| 2.7.1.54 | D-arabinokinase | True | 0 | 0 | 0 | 1 | ATP + D-arabinose = ADP + D-arabinose 5-phosphate | ATP:D-arabinose 5-phosphotransferase | None | D-arabinokinase (phosphorylating) | |
| 2.7.1.55 | allose kinase | False | 1 | 373 | 1 | 1 | ATP + D-allose = ADP + D-allose 6-phosphate | ATP:D-allose 6-phosphotransferase | None | allokinase (phosphorylating); allokinase; D-allokinase; D-allose-6-kinase | |
| 2.7.1.56 | 1-phosphofructokinase | False | 13 | 3094 | 1 | 12 | ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate | ATP:D-fructose-phosphate 6-phosphotransferase | None | fructose-1-phosphate kinase; 1-phosphofructokinase (phosphorylating); D-fructose-1-phosphate kinase; fructose 1-phosphate kinase; phosphofructokinase 1 | |
| 2.7.1.58 | 2-dehydro-3-deoxygalactonokinase | False | 3 | 1093 | 2 | 7 | ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate | ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase | None | 2-keto-3-deoxygalactonokinase; 2-keto-3-deoxygalactonate kinase (phosphorylating); 2-oxo-3-deoxygalactonate kinase | |
| 2.7.1.59 | N-acetylglucosamine kinase | False | 78 | 5361 | 10 | 13 | ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate | ATP:N-acetyl-D-glucosamine 6-phosphotransferase | None | acetylglucosamine kinase (phosphorylating); ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase; 2-acetylamino-2-deoxy-D-glucose kinase; acetylaminodeoxyglucokinase | |
| 2.7.1.60 | N-acylmannosamine kinase | False | 66 | 1508 | 10 | 7 | ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate | ATP:N-acyl-D-mannosamine 6-phosphotransferase | None | acylmannosamine kinase (phosphorylating); acetylamidodeoxymannokinase; acetylmannosamine kinase; acylaminodeoxymannokinase; acylmannosamine kinase; N-acyl-D-mannosamine kinase; N-acetylmannosamine kinase; ATP:N-acetylmannosamine 6-phosphotransferase | |
| 2.7.1.61 | acyl-phosphate---hexose phosphotransferase | True | 0 | 0 | 0 | 1 | acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate | acyl-phosphate:D-hexose phosphotransferase | None | hexose phosphate:hexose phosphotransferase | |
| 2.7.1.62 | phosphoramidate---hexose phosphotransferase | True | 0 | 0 | 0 | 1 | phosphoramidate + D-hexose = NH3 + alpha-D-hexose 1-phosphate | phosphoramidate:D-hexose 1-phosphotransferase | None | phosphoramidate-hexose transphosphorylase; phosphoramidic-hexose transphosphorylase; phosphoramidate:hexose 1-phosphotransferase | |
| 2.7.1.63 | polyphosphate---glucose phosphotransferase | False | 4 | 813 | 1 | 21 | (phosphate)n + D-glucose = (phosphate)n-1 + D-glucose 6-phosphate | polyphosphate:D-glucose 6-phosphotransferase | None | polyphosphate glucokinase; polyphosphate-D-(+)-glucose-6-phosphotransferase; polyphosphate-glucose 6-phosphotransferase | |
| 2.7.1.64 | inositol 3-kinase | False | 3 | 6 | 2 | 9 | ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate | ATP:myo-inositol 1-phosphotransferase | None | inositol-1-kinase (phosphorylating); myoinositol kinase; myo-inositol 1-kinase | |
| 2.7.1.65 | scyllo-inosamine 4-kinase | False | 0 | 7 | 0 | 2 | ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate | ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase | None | scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase | |
| 2.7.1.66 | undecaprenol kinase | False | 2 | 616 | 0 | 7 | ATP + undecaprenol = ADP + undecaprenyl phosphate | ATP:undecaprenol phosphotransferase | None | isoprenoid alcohol kinase; isoprenoid alcohol phosphokinase; C55-isoprenoid alcohol phosphokinase; isoprenoid alcohol kinase (phosphorylating); C55-isoprenoid alcohol kinase; C55-isoprenyl alcohol phosphokinase; polyisoprenol kinase | |
| 2.7.1.67 | 1-phosphatidylinositol 4-kinase | False | 54 | 15787 | 29 | 26 | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase | None | phosphatidylinositol kinase (phosphorylating); phosphatidylinositol 4-kinase; phosphatidylinositol kinase; type II phosphatidylinositol kinase; PI kinase; PI 4-kinase | |
| 2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase | False | 28 | 4806 | 4 | 15 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase | None | diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase | |
| 2.7.1.71 | shikimate kinase | False | 525 | 46855 | 37 | 31 | ATP + shikimate = ADP + 3-phosphoshikimate | ATP:shikimate 3-phosphotransferase | None | shikimate kinase (phosphorylating); shikimate kinase II | |
| 2.7.1.72 | streptomycin 6-kinase | False | 2 | 375 | 0 | 4 | ATP + streptomycin = ADP + streptomycin 6-phosphate | ATP:streptomycin 6-phosphotransferase | None | streptidine kinase; SM 6-kinase; streptomycin 6-kinase (phosphorylating); streptidine kinase (phosphorylating); streptomycin 6-O-phosphotransferase; streptomycin 6-phosphotransferase | |
| 2.7.1.73 | inosine kinase | False | 6 | 2134 | 2 | 8 | ATP + inosine = ADP + IMP | ATP:inosine 5'-phosphotransferase | None | inosine-guanosine kinase; inosine kinase (phosphorylating) | |
| 2.7.1.74 | deoxycytidine kinase | False | 14 | 291 | 58 | 11 | NTP + deoxycytidine = NDP + dCMP | NTP:deoxycytidine 5'-phosphotransferase | None | deoxycytidine kinase (phosphorylating); 2'-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase | |
| 2.7.1.76 | 2'-deoxyadenosine kinase | False | 14 | 412 | 1 | 15 | ATP + 2'-deoxyadenosine = ADP + dAMP | ATP:2'-deoxyadenosine 5'-phosphotransferase | None | purine-deoxyribonucleoside kinase; deoxyadenosine kinase (phosphorylating) (ambiguous); purine-deoxyribonucleoside kinase (ambiguous); deoxyadenosine kinase (ambiguous); ATP:deoxyadenosine 5'-phosphotransferase (ambiguous) | |
| 2.7.1.77 | nucleoside phosphotransferase | False | 9 | 1853 | 0 | 8 | a nucleotide + a 2'-deoxyribonucleoside = a nucleoside + a 2'-deoxyribonucleoside 5'-phosphate | nucleotide:nucleoside 5'-phosphotransferase | None | nonspecific nucleoside phosphotransferase; nucleotide:3'-deoxynucleoside 5'-phosphotransferase | |
| 2.7.1.78 | polynucleotide 5'-hydroxyl-kinase | False | 24 | 1528 | 16 | 18 | ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA | ATP:5'-dephosphopolynucleotide 5'-phosphotransferase | None | ATP:5'-dephosphopolynucleotide 5'-phosphatase; PNK; polynucleotide 5'-hydroxyl kinase (phosphorylating); 5'-hydroxyl polynucleotide kinase; 5'-hydroxyl polyribonucleotide kinase; 5'-hydroxyl RNA kinase; DNA 5'-hydroxyl kinase; DNA kinase; polynucleotide kinase; polynucleotide 5'-hydroxy-kinase | |
| 2.7.1.79 | diphosphate---glycerol phosphotransferase | True | 0 | 0 | 0 | 1 | diphosphate + glycerol = phosphate + glycerol 1-phosphate | diphosphate:glycerol 1-phosphotransferase | None | PPi-glycerol phosphotransferase; pyrophosphate-glycerol phosphotransferase | |
| 2.7.1.80 | diphosphate---serine phosphotransferase | True | 0 | 0 | 0 | 1 | diphosphate + L-serine = phosphate + O-phospho-L-serine | diphosphate:L-serine O-phosphotransferase | None | pyrophosphate-serine phosphotransferase; pyrophosphate-L-serine phosphotransferase | |
| 2.7.1.81 | hydroxylysine kinase | False | 5 | 3306 | 0 | 8 | GTP + 5-hydroxy-L-lysine = GDP + 5-phosphooxy-L-lysine | GTP:5-hydroxy-L-lysine O-phosphotransferase | None | hydroxylysine kinase (phosphorylating); guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase | |
| 2.7.1.82 | ethanolamine kinase | False | 18 | 7617 | 0 | 26 | ATP + ethanolamine = ADP + O-phosphoethanolamine | ATP:ethanolamine O-phosphotransferase | None | ethanolamine kinase (phosphorylating); ethanolamine phosphokinase | |
| 2.7.1.83 | pseudouridine kinase | False | 3 | 626 | 5 | 2 | ATP + pseudouridine = ADP + pseudouridine 5'-phosphate | ATP:pseudouridine 5'-phosphotransferase | None | pseudouridine kinase (phosphorylating) | |
| 2.7.1.84 | alkylglycerone kinase | True | 0 | 0 | 0 | 1 | ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate | ATP:O-alkylglycerone phosphotransferase | None | alkyldihydroxyacetone kinase (phosphorylating); alkyldihydroxyacetone kinase | |
| 2.7.1.85 | beta-glucoside kinase | False | 3 | 720 | 1 | 4 | ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1->4)-D-glucose | ATP:cellobiose 6-phosphotransferase | None | beta-D-glucoside kinase (phosphorylating) | |
| 2.7.1.86 | NADH kinase | False | 6 | 59 | 1 | 9 | ATP + NADH = ADP + NADPH | ATP:NADH 2'-phosphotransferase | None | reduced nicotinamide adenine dinucleotide kinase (phosphorylating); DPNH kinase; reduced diphosphopyridine nucleotide kinase; NADH kinase | |
| 2.7.1.87 | streptomycin 3''-kinase | False | 2 | 121 | 0 | 1 | ATP + streptomycin = ADP + streptomycin 3''-phosphate | ATP:streptomycin 3''-phosphotransferase | None | streptomycin 3''-kinase (phosphorylating); streptomycin 3''-phosphotransferase | |
| 2.7.1.88 | dihydrostreptomycin-6-phosphate 3'alpha-kinase | True | 0 | 0 | 0 | 1 | ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate | ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase | None | dihydrostreptomycin 6-phosphate kinase (phosphorylating); ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase | |
| 2.7.1.89 | thiamine kinase | False | 36 | 1514 | 0 | 2 | ATP + thiamine = ADP + thiamine phosphate | ATP:thiamine phosphotransferase | None | thiamin kinase (phosphorylating); thiamin phosphokinase; ATP:thiamin phosphotransferase; thiamin kinase | |
| 2.7.1.90 | diphosphate---fructose-6-phosphate 1-phosphotransferase | False | 28 | 15613 | 4 | 58 | diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate | diphosphate:D-fructose-6-phosphate 1-phosphotransferase | None | 6-phosphofructokinase (pyrophosphate); pyrophosphate-fructose 6-phosphate 1-phosphotransferase; inorganic pyrophosphate-dependent phosphofructokinase; inorganic pyrophosphate-phosphofructokinase; pyrophosphate-dependent phosphofructo-1-kinase; pyrophosphate-fructose 6-phosphate phosphotransferase | |
| 2.7.1.91 | sphingosine kinase | False | 13 | 3689 | 5 | 15 | ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | ATP:sphingoid base 1-phosphotransferase | None | SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase | |
| 2.7.1.92 | 5-dehydro-2-deoxygluconokinase | False | 31 | 5900 | 0 | 1 | ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate | ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase | None | 5-keto-2-deoxygluconokinase; 5-keto-2-deoxyglucono kinase (phosphorylating); DKH kinase | |
| 2.7.1.93 | alkylglycerol kinase | False | 11 | 7 | 0 | 1 | ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate | ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase | None | 1-alkylglycerol kinase (phosphorylating); ATP-alkylglycerol phosphotransferase; alkylglycerol phosphotransferase; ATP: 1-alkyl-sn-glycerol phosphotransferase | |
| 2.7.1.94 | acylglycerol kinase | False | 5 | 1521 | 0 | 8 | ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate | ATP:acylglycerol 3-phosphotransferase | None | monoacylglycerol kinase; monoacylglycerol kinase (phosphorylating); sn-2-monoacylglycerol kinase; MGK; monoglyceride kinase; monoglyceride phosphokinase | |
| 2.7.1.95 | kanamycin kinase | False | 12 | 2096 | 17 | 9 | ATP + kanamycin = ADP + kanamycin 3'-phosphate | ATP:kanamycin 3'-O-phosphotransferase | None | neomycin-kanamycin phosphotransferase; | |
| 2.7.1.100 | S-methyl-5-thioribose kinase | False | 46 | 4303 | 7 | 12 | ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate | ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase | None | 5-methylthioribose kinase (phosphorylating); methylthioribose kinase; 5-methylthioribose kinase; ATP:<em>S</em><small><sup>5</sup></small>-methyl-5-thio-D-ribose 1-phosphotransferase | |
| 2.7.1.101 | tagatose kinase | False | 1 | 5 | 1 | 1 | ATP + D-tagatose = ADP + D-tagatose 6-phosphate | ATP:D-tagatose 6-phosphotransferase | None | AtuFK | |
| 2.7.1.102 | hamamelose kinase | True | 0 | 0 | 0 | 1 | ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate | ATP:D-hamamelose 2'-phosphotransferase | None | hamamelose kinase (phosphorylating); hamamelosekinase (ATP: hamamelose 2'-phosphotransferase); ATP/hamamelose 2'-phosphotransferase | |
| 2.7.1.103 | viomycin kinase | False | 1 | 4 | 0 | 3 | ATP + viomycin = ADP + O-phosphoviomycin | ATP:viomycin O-phosphotransferase | None | viomycin phosphotransferase; capreomycin phosphotransferase | |
| 2.7.1.105 | 6-phosphofructo-2-kinase | False | 27 | 2574 | 30 | 24 | ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | ATP:beta-D-fructose-6-phosphate 2-phosphotransferase | None | phosphofructokinase 2; 6-phosphofructose 2-kinase; 6-phosphofructo-2-kinase (phosphorylating); fructose 6-phosphate 2-kinase; ATP:D-fructose-6-phosphate 2-phosphotransferase | |
| 2.7.1.106 | glucose-1,6-bisphosphate synthase | False | 3 | 30 | 0 | 3 | 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate | 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase | None | glucose 1,6-diphosphate synthase; glucose-1,6-bisphosphate synthetase; 3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase | |
| 2.7.1.107 | diacylglycerol kinase (ATP) | False | 87 | 36636 | 29 | 25 | ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate | ATP:1,2-diacyl-sn-glycerol 3-phosphotransferase | None | diglyceride kinase (ambiguous); 1,2-diacylglycerol kinase (phosphorylating) (ambiguous); 1,2-diacylglycerol kinase (ambiguous); sn-1,2-diacylglycerol kinase (ambiguous); DG kinase (ambiguous); DGK (ambiguous); ATP:diacylglycerol phosphotransferase; arachidonoyl-specific diacylglycerol kinase; diacylglycerol:ATP kinase; ATP:1,2-diacylglycerol 3-phosphotransferase; diacylglycerol kinase (ATP dependent) | |
| 2.7.1.108 | dolichol kinase | False | 6 | 3903 | 0 | 11 | CTP + dolichol = CDP + dolichyl phosphate | CTP:dolichol O-phosphotransferase | None | dolichol phosphokinase | |
| 2.7.1.113 | deoxyguanosine kinase | False | 15 | 662 | 3 | 9 | ATP + deoxyguanosine = ADP + dGMP | ATP:deoxyguanosine 5'-phosphotransferase | None | deoxyguanosine kinase (phosphorylating); (dihydroxypropoxymethyl)guanine kinase; 2'-deoxyguanosine kinase; NTP-deoxyguanosine 5'-phosphotransferase | |
| 2.7.1.114 | AMP---thymidine kinase | True | 0 | 0 | 0 | 6 | AMP + thymidine = adenosine + dTMP | AMP:thymidine 5'-phosphotransferase | None | adenylate-nucleoside phosphotransferase | |
| 2.7.1.118 | ADP---thymidine kinase | True | 0 | 0 | 0 | 1 | ADP + thymidine = AMP + dTMP | ADP:thymidine 5'-phosphotransferase | None | ADP:dThd phosphotransferase; adenosine diphosphate-thymidine phosphotransferase | |
| 2.7.1.119 | hygromycin-B 7''-O-kinase | False | 1 | 27 | 1 | 2 | ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B | ATP:hygromycin-B 7''-O-phosphotransferase | None | hygromycin B phosphotransferase; hygromycin-B kinase (ambiguous) | |
| 2.7.1.121 | phosphoenolpyruvate---glycerone phosphotransferase | False | 15 | 9401 | 0 | 1 | phosphoenolpyruvate + glycerone = pyruvate + glycerone phosphate | phosphoenolpyruvate:glycerone phosphotransferase | None | None | |
| 2.7.1.122 | xylitol kinase | True | 0 | 0 | 0 | 1 | ATP + xylitol = ADP + xylitol 5-phosphate | ATP:xylitol 5-phosphotransferase | None | None | |
| 2.7.1.127 | inositol-trisphosphate 3-kinase | False | 11 | 6 | 16 | 14 | ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase | None | 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase | |
| 2.7.1.130 | tetraacyldisaccharide 4'-kinase | False | 376 | 24701 | 8 | 3 | ATP + a lipid A disaccharide = ADP + a lipid IVA | ATP:2-deoxy-2-{[(3R)-3-hydroxyacyl]amino}-3-O-[(3R)-3-hydroxyacyl]-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-{[(3R)-3-hydroxyacyl]amino}-1-O-phospho-alpha-D-glucopyranose 4'-O-phosphotransferase | None | lpxK (gene name); lipid-A 4'-kinase; ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl-(1->6)-alpha-D-glucosaminyl-phosphate 4'-O-phosphotransferase | |
| 2.7.1.134 | inositol-tetrakisphosphate 1-kinase | False | 27 | 3126 | 8 | 9 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase | None | 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase | |
| 2.7.1.136 | macrolide 2'-kinase | False | 0 | 1 | 0 | 5 | ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate | ATP:macrolide 2'-O-phosphotransferase | None | None | |
| 2.7.1.137 | phosphatidylinositol 3-kinase | False | 38 | 5189 | 93 | 29 | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | None | 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase | |
| 2.7.1.138 | ceramide kinase | False | 10 | 1586 | 0 | 6 | ATP + ceramide = ADP + ceramide 1-phosphate | ATP:ceramide 1-phosphotransferase | None | acylsphingosine kinase | |
| 2.7.1.140 | inositol-tetrakisphosphate 5-kinase | False | 7 | 685 | 1 | 3 | ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase | None | 1D-myo-inositol-tetrakisphosphate 5-kinase | |
| 2.7.1.142 | glycerol-3-phosphate---glucose phosphotransferase | True | 0 | 0 | 0 | 1 | sn-glycerol 3-phosphate + D-glucose = glycerol + D-glucose 6-phosphate | sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase | None | None | |
| 2.7.1.143 | diphosphate-purine nucleoside kinase | False | 0 | 0 | 5 | 7 | diphosphate + a purine nucleoside = phosphate + a purine mononucleotide | diphosphate:purine nucleoside phosphotransferase | None | pyrophosphate-purine nucleoside kinase | |
| 2.7.1.144 | tagatose-6-phosphate kinase | False | 54 | 7711 | 8 | 6 | ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate | ATP:D-tagatose-6-phosphate 1-phosphotransferase | None | None | |
| 2.7.1.145 | deoxynucleoside kinase | False | 1 | 21 | 15 | 6 | ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate | ATP:deoxyribonucleoside 5'-phosphotransferase | None | multispecific deoxynucleoside kinase; ms-dNK; multisubstrate deoxyribonucleoside kinase; multifunctional deoxynucleoside kinase; D. melanogaster deoxynucleoside kinase; Dm-dNK; ATP:deoxynucleoside 5'-phosphotransferase | |
| 2.7.1.146 | ADP-specific phosphofructokinase | False | 8 | 243 | 6 | 12 | ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate | ADP:D-fructose-6-phosphate 1-phosphotransferase | None | ADP-6-phosphofructokinase; ADP-dependent phosphofructokinase | |
| 2.7.1.147 | ADP-specific glucose/glucosamine kinase | False | 11 | 178 | 10 | 15 | (1) ADP + D-glucose = AMP + D-glucose 6-phosphate;;(2) ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate | ADP:D-glucose/D-glucosamine 6-phosphotransferase | None | ADP-specific glucokinase; ADP-dependent glucokinase | |
| 2.7.1.148 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | False | 587 | 35471 | 17 | 13 | ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase | None | CDP-ME kinase | |
| 2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase | False | 16 | 2578 | 42 | 9 | ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase | None | type II PIP kinase | |
| 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase | False | 10 | 5913 | 1 | 12 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | None | type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase | |
| 2.7.1.151 | inositol-polyphosphate multikinase | False | 9 | 687 | 13 | 9 | 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction);;(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate;;(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase | None | IpK2; IP3/IP4 6-/3-kinase; IP3/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2alpha; AtIpk2beta; inositol polyphosphate 6-/3-/5-kinase | |
| 2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase | False | 18 | 4128 | 224 | 12 | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | None | type I phosphoinositide 3-kinase | |
| 2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase | False | 10 | 102 | 13 | 7 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase | None | type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase | |
| 2.7.1.156 | adenosylcobinamide kinase | False | 5 | 19879 | 1 | 5 | RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP [where RTP is either ATP or GTP (for symbol definitions, <a target = "new" href = "http://www.chem.qmul.ac.uk/iubmb/misc/naseq.html#300">click here<a>)] | RTP:adenosylcobinamide phosphotransferase | None | CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase | |
| 2.7.1.157 | N-acetylgalactosamine kinase | False | 4 | 50 | 0 | 3 | ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase | None | GALK2; GK2; GalNAc kinase; N-acetylgalactosamine (GalNAc)-1-phosphate kinase; ATP:N-acetyl-D-galactosamine 1-phosphotransferase | |
| 2.7.2.1 | acetate kinase | False | 353 | 31229 | 12 | 65 | ATP + acetate = ADP + acetyl phosphate | ATP:acetate phosphotransferase | None | acetokinase; AckA; AK; acetic kinase; acetate kinase (phosphorylating) | |
| 2.7.2.2 | carbamate kinase | False | 48 | 1271 | 11 | 22 | ATP + NH3 + hydrogencarbonate = ADP + carbamoyl phosphate + H2O (overall reaction);;(1a) ATP + carbamate = ADP + carbamoyl phosphate;;(1b) NH3 + hydrogencarbonate = carbamate + H2O (spontaneous) | ATP:carbamate phosphotransferase | None | CKase; carbamoyl phosphokinase; carbamyl phosphokinase | |
| 2.7.2.3 | phosphoglycerate kinase | False | 724 | 56504 | 64 | 87 | ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate | ATP:3-phospho-D-glycerate 1-phosphotransferase | None | PGK; 3-PGK; ATP-3-phospho-D-glycerate-1-phosphotransferase; ATP:D-3-phosphoglycerate 1-phosphotransferase; 3-phosphoglycerate kinase; 3-phosphoglycerate phosphokinase; 3-phosphoglyceric acid kinase; 3-phosphoglyceric acid phosphokinase; 3-phosphoglyceric kinase; glycerate 3-phosphate kinase; glycerophosphate kinase; phosphoglyceric acid kinase; phosphoglyceric kinase; phosphoglycerokinase | |
| 2.7.2.4 | aspartate kinase | False | 52 | 60293 | 22 | 59 | ATP + L-aspartate = ADP + 4-phospho-L-aspartate | ATP:L-aspartate 4-phosphotransferase | None | aspartokinase; AK; beta-aspartokinase; aspartic kinase | |
| 2.7.2.6 | formate kinase | True | 0 | 0 | 0 | 1 | ATP + formate = ADP + formyl phosphate | ATP:formate phosphotransferase | None | None | |
| 2.7.2.7 | butyrate kinase | False | 48 | 5907 | 2 | 13 | ATP + butanoate = ADP + butanoyl phosphate | ATP:butanoate 1-phosphotransferase | None | None | |
| 2.7.2.8 | acetylglutamate kinase | False | 570 | 34329 | 39 | 17 | ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate | ATP:N-acetyl-L-glutamate 5-phosphotransferase | None | N-acetylglutamate 5-phosphotransferase; acetylglutamate phosphokinase; N-acetylglutamate phosphokinase; N-acetylglutamate kinase; N-acetylglutamic 5-phosphotransferase | |
| 2.7.2.10 | phosphoglycerate kinase (GTP) | True | 0 | 0 | 0 | 1 | GTP + 3-phospho-D-glycerate = GDP + 3-phospho-D-glyceroyl phosphate | GTP:3-phospho-D-glycerate 1-phosphotransferase | None | None | |
| 2.7.2.11 | glutamate 5-kinase | False | 454 | 35432 | 23 | 14 | ATP + L-glutamate = ADP + L-glutamate 5-phosphate | ATP:L-glutamate 5-phosphotransferase | None | ATP-L-glutamate 5-phosphotransferase; ATP:gamma-L-glutamate phosphotransferase; gamma-glutamate kinase; gamma-glutamyl kinase; glutamate kinase | |
| 2.7.2.12 | acetate kinase (diphosphate) | False | 0 | 0 | 1 | 1 | diphosphate + acetate = phosphate + acetyl phosphate | diphosphate:acetate phosphotransferase | None | pyrophosphate-acetate phosphotransferase | |
| 2.7.2.14 | branched-chain-fatty-acid kinase | True | 0 | 0 | 0 | 2 | ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate | ATP:branched-chain-fatty-acid 1-phosphotransferase | None | isobutyrate kinase | |
| 2.7.2.15 | propionate kinase | False | 22 | 1661 | 20 | 3 | ATP + propanoate = ADP + propanoyl phosphate | ATP:propanoate phosphotransferase | None | PduW; TdcD; propionate/acetate kinase | |
| 2.7.3.1 | guanidinoacetate kinase | False | 1 | 0 | 3 | 7 | ATP + guanidinoacetate = ADP + phosphoguanidinoacetate | ATP:guanidinoacetate N-phosphotransferase | None | glycocyamine kinase | |
| 2.7.3.2 | creatine kinase | False | 34 | 5307 | 19 | 44 | ATP + creatine = ADP + phosphocreatine | ATP:creatine N-phosphotransferase | None | ATP:creatine phosphotransferase; CK; MM-CK; MB-CK; BB-CK; creatine phosphokinase; creatine phosphotransferase; phosphocreatine kinase; adenosine triphosphate-creatine transphosphorylase; Mi-CK; CK-BB; CK-MM; CK-MB; CKMiMi; MiMi-CK | |
| 2.7.3.3 | arginine kinase | False | 31 | 11762 | 27 | 147 | ATP + L-arginine = ADP + Nomega-phospho-L-arginine | ATP:L-arginine Nomega-phosphotransferase | None | arginine phosphokinase; adenosine 5'-triphosphate: L-arginine phosphotransferase; adenosine 5'-triphosphate-arginine phosphotransferase; ATP:L-arginine N-phosphotransferasel ATP:L-arginine omega-N-phosphotransferase | |
| 2.7.3.4 | taurocyamine kinase | False | 2 | 0 | 3 | 12 | ATP + taurocyamine = ADP + N-phosphotaurocyamine | ATP:taurocyamine N-phosphotransferase | None | taurocyamine phosphotransferase; ATP:taurocyamine phosphotransferase | |
| 2.7.3.5 | lombricine kinase | False | 2 | 2 | 2 | 9 | ATP + lombricine = ADP + N-phospholombricine | ATP:lombricine N-phosphotransferase | None | None | |
| 2.7.3.6 | hypotaurocyamine kinase | True | 0 | 0 | 0 | 1 | ATP + hypotaurocyamine = ADP + Nomega-phosphohypotaurocyamine | ATP:hypotaurocyamine N-phosphotransferase | None | None | |
| 2.7.3.7 | opheline kinase | True | 0 | 0 | 0 | 1 | ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate | ATP:guanidinoethyl-methyl-phosphate phosphotransferase | None | None | |
| 2.7.3.8 | ammonia kinase | True | 0 | 0 | 0 | 1 | ATP + NH3 = ADP + phosphoramide | ATP:ammonia phosphotransferase | None | phosphoramidate-adenosine diphosphate phosphotransferase; phosphoramidate-ADP-phosphotransferase | |
| 2.7.3.9 | phosphoenolpyruvate---protein phosphotransferase | False | 51 | 37953 | 28 | 24 | phosphoenolpyruvate + protein histidine = pyruvate + protein Npi-phospho-L-histidine | phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase | None | phosphoenolpyruvate sugar phosphotransferase enzyme I; phosphopyruvate-protein factor phosphotransferase; phosphopyruvate-protein phosphotransferase; sugar-PEP phosphotransferase enzyme I; phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase | |
| 2.7.3.10 | agmatine kinase | True | 0 | 0 | 0 | 1 | ATP + agmatine = ADP + N4-phosphoagmatine | ATP:agmatine N4-phosphotransferase | None | phosphagen phosphokinase; ATP:agmatine 4-N-phosphotransferase | |
| 2.7.4.1 | ATP-polyphosphate phosphotransferase | False | 94 | 33665 | 10 | 70 | ATP + (phosphate)n = ADP + (phosphate)n+1 | ATP:polyphosphate phosphotransferase | None | polyphosphate kinase 1; ppk1 (gene name); polyphosphate kinase (ambiguous); polyphosphoric acid kinase (ambiguous) | |
| 2.7.4.2 | phosphomevalonate kinase | False | 13 | 6077 | 4 | 14 | ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate | ATP:(R)-5-phosphomevalonate phosphotransferase | None | ATP:5-phosphomevalonate phosphotransferase; 5-phosphomevalonate kinase; mevalonate phosphate kinase; mevalonate-5-phosphate kinase; mevalonic acid phosphate kinase | |
| 2.7.4.3 | adenylate kinase | False | 903 | 67466 | 126 | 73 | ATP + AMP = 2 ADP | ATP:AMP phosphotransferase | None | myokinase; 5'-AMP-kinase; adenylic kinase; adenylokinase | |
| 2.7.4.4 | nucleoside-phosphate kinase | False | 2 | 1 | 3 | 3 | ATP + nucleoside phosphate = ADP + nucleoside diphosphate | ATP:nucleoside-phosphate phosphotransferase | None | NMP-kinase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | False | 782 | 53295 | 185 | 97 | ATP + nucleoside diphosphate = ADP + nucleoside triphosphate | ATP:nucleoside-diphosphate phosphotransferase | None | nucleoside 5'-diphosphate kinase; nucleoside diphosphate (UDP) kinase; nucleoside diphosphokinase; nucleotide phosphate kinase; UDP kinase; uridine diphosphate kinase | |
| 2.7.4.7 | phosphooxymethylpyrimidine kinase | False | 29 | 10880 | 8 | 9 | ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine | ATP:4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine phosphotransferase | None | hydroxymethylpyrimidine phosphokinase; ATP:4-amino-2-methyl-5-phosphooxymethylpyrimidine phosphotransferase; ATP:(4-amino-2-methylpyrimidin-5-yl)methyl-phosphate phosphotransferase; phosphomethylpyrimidine kinase | |
| 2.7.4.8 | guanylate kinase | False | 339 | 43595 | 32 | 21 | ATP + GMP = ADP + GDP | ATP:(d)GMP phosphotransferase | None | deoxyguanylate kinase; 5'-GMP kinase; GMP kinase; guanosine monophosphate kinase; ATP:GMP phosphotransferase | |
| 2.7.4.9 | dTMP kinase | False | 616 | 47100 | 120 | 30 | ATP + dTMP = ADP + dTDP | ATP:dTMP phosphotransferase | None | thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase | |
| 2.7.4.10 | nucleoside-triphosphate---adenylate kinase | False | 21 | 2890 | 5 | 6 | nucleoside triphosphate + AMP = nucleoside diphosphate + ADP | nucleoside-triphosphate:AMP phosphotransferase | None | guanosine triphosphate-adenylate kinase; nucleoside triphosphate-adenosine monophosphate transphosphorylase; GTP:AMP phosphotransferase; isozyme 3 of adenylate kinase | |
| 2.7.4.11 | (deoxy)adenylate kinase | True | 0 | 0 | 0 | 2 | ATP + dAMP = ADP + dADP | ATP:(d)AMP phosphotransferase | None | None | |
| 2.7.4.12 | T2-induced deoxynucleotide kinase | True | 0 | 0 | 0 | 1 | ATP + dGMP (or dTMP) = ADP + dGDP (or dTDP) | ATP:(d)NMP phosphotransferase | None | None | |
| 2.7.4.13 | (deoxy)nucleoside-phosphate kinase | False | 4 | 157 | 2 | 2 | ATP + a 2'-deoxyribonucleoside 5'-phosphate = ADP + a 2'-deoxyribonucleoside 5'-diphosphate | ATP:2'-deoxyribonucleoside-5'-phosphate phosphotransferase | None | deoxynucleoside monophosphate kinase; deoxyribonucleoside monophosphokinase; deoxynucleoside-5'-monophosphate kinase; ATP:deoxynucleoside-phosphate phosphotransferase | |
| 2.7.4.14 | UMP/CMP kinase | False | 25 | 4039 | 22 | 12 | (1) ATP + (d)CMP = ADP + (d)CDP;;(2) ATP + UMP = ADP + UDP | ATP:(d)CMP/UMP phosphotransferase | None | cytidylate kinase (misleading); deoxycytidylate kinase (misleading); CTP:CMP phosphotransferase (misleading); dCMP kinase (misleading); deoxycytidine monophosphokinase (misleading); UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase | |
| 2.7.4.15 | thiamine-diphosphate kinase | True | 0 | 0 | 0 | 6 | ATP + thiamine diphosphate = ADP + thiamine triphosphate | ATP:thiamine-diphosphate phosphotransferase | None | ATP:thiamin-diphosphate phosphotransferase; TDP kinase; thiamin diphosphate kinase; thiamin diphosphate phosphotransferase; thiamin pyrophosphate kinase; thiamine diphosphate kinase; protein bound thiamin diphosphate:ATP phosphoryltransferase | |
| 2.7.4.16 | thiamine-phosphate kinase | False | 27 | 29199 | 14 | 6 | ATP + thiamine phosphate = ADP + thiamine diphosphate | ATP:thiamine-phosphate phosphotransferase | None | thiamin-monophosphate kinase; thiamin monophosphatase; thiamin monophosphokinase | |
| 2.7.4.17 | 3-phosphoglyceroyl-phosphate---polyphosphate phosphotransferase | True | 0 | 0 | 0 | 5 | 3-phospho-D-glyceroyl phosphate + (phosphate)n = 3-phosphoglycerate + (phosphate)n+1 | 3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase | None | diphosphoglycerate-polyphosphate phosphotransferase; 1,3-diphosphoglycerate-polyphosphate phosphotransferase | |
| 2.7.4.18 | farnesyl-diphosphate kinase | True | 0 | 0 | 0 | 1 | ATP + farnesyl diphosphate = ADP + farnesyl triphosphate | ATP:farnesyl-diphosphate phosphotransferase | None | farnesyl pyrophosphate kinase | |
| 2.7.4.19 | 5-methyldeoxycytidine-5'-phosphate kinase | True | 0 | 0 | 0 | 1 | ATP + 5-methyldeoxycytidine 5'-phosphate = ADP + 5-methyldeoxycytidine diphosphate | ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase | None | None | |
| 2.7.4.20 | dolichyl-diphosphate---polyphosphate phosphotransferase | True | 0 | 0 | 0 | 2 | dolichyl diphosphate + (phosphate)n = dolichyl phosphate + (phosphate)n+1 | dolichyl-diphosphate:polyphosphate phosphotransferase | None | dolichylpyrophosphate:polyphosphate phosphotransferase | |
| 2.7.4.21 | inositol-hexakisphosphate 5-kinase | False | 9 | 7 | 17 | 10 | (1) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate;;(2) ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate | ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase | None | ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; IP6K; inositol-hexakisphosphate kinase (ambiguous) | |
| 2.7.6.1 | ribose-phosphate diphosphokinase | False | 204 | 58619 | 46 | 27 | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | ATP:D-ribose-5-phosphate diphosphotransferase | None | ribose-phosphate pyrophosphokinase; PRPP synthetase; phosphoribosylpyrophosphate synthetase; PPRibP synthetase; PP-ribose P synthetase; 5-phosphoribosyl-1-pyrophosphate synthetase; 5-phosphoribose pyrophosphorylase; 5-phosphoribosyl-alpha-1-pyrophosphate synthetase; phosphoribosyl-diphosphate synthetase; phosphoribosylpyrophosphate synthase; pyrophosphoribosylphosphate synthetase; ribophosphate pyrophosphokinase; ribose-5-phosphate pyrophosphokinase | |
| 2.7.6.2 | thiamine diphosphokinase | False | 9 | 16940 | 8 | 15 | ATP + thiamine = AMP + thiamine diphosphate | ATP:thiamine diphosphotransferase | None | thiamin kinase; thiamine pyrophosphokinase; ATP:thiamin pyrophosphotransferase; thiamin pyrophosphokinase; thiamin pyrophosphotransferase; thiaminokinase; thiamin:ATP pyrophosphotransferase; TPTase | |
| 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | False | 41 | 43840 | 73 | 14 | ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate | ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase | None | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; H2-pteridine-CH2OH pyrophosphokinase; 7,8-dihydroxymethylpterin-pyrophosphokinase; HPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; hydroxymethyldihydropteridine pyrophosphokinase; ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase | |
| 2.7.6.4 | nucleotide diphosphokinase | True | 0 | 0 | 0 | 6 | ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate | ATP:nucleoside-5'-phosphate diphosphotransferase | None | nucleotide pyrophosphokinase; ATP:nucleotide pyrophosphotransferase; ATP nucleotide 3'-pyrophosphokinase; nucleotide 3'-pyrophosphokinase | |
| 2.7.6.5 | GTP diphosphokinase | False | 45 | 18515 | 30 | 20 | ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate | ATP:GTP 3'-diphosphotransferase | None | stringent factor; guanosine 3',5'-polyphosphate synthase; GTP pyrophosphokinase; ATP-GTP 3'-diphosphotransferase; guanosine 5',3'-polyphosphate synthetase; (p)ppGpp synthetase I; (p)ppGpp synthetase II; guanosine pentaphosphate synthetase; GPSI; GPSII | |
| 2.7.7.1 | nicotinamide-nucleotide adenylyltransferase | False | 68 | 8885 | 28 | 35 | ATP + nicotinamide ribonucleotide = diphosphate + NAD+ | ATP:nicotinamide-nucleotide adenylyltransferase | None | NAD+ pyrophosphorylase; adenosine triphosphate-nicotinamide mononucleotide transadenylase; ATP:NMN adenylyltransferase; diphosphopyridine nucleotide pyrophosphorylase; nicotinamide adenine dinucleotide pyrophosphorylase; nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase | |
| 2.7.7.2 | FAD synthase | False | 89 | 46394 | 8 | 14 | ATP + FMN = diphosphate + FAD | ATP:FMN adenylyltransferase | None | FAD pyrophosphorylase; riboflavin mononucleotide adenylyltransferase; adenosine triphosphate-riboflavin mononucleotide transadenylase; adenosine triphosphate-riboflavine mononucleotide transadenylase; riboflavin adenine dinucleotide pyrophosphorylase; riboflavine adenine dinucleotide adenylyltransferase; flavin adenine dinucleotide synthetase; FADS; FMN adenylyltransferase; FAD synthetase (misleading) | |
| 2.7.7.3 | pantetheine-phosphate adenylyltransferase | False | 681 | 40986 | 114 | 24 | ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA | ATP:pantetheine-4'-phosphate adenylyltransferase | None | dephospho-CoA pyrophosphorylase; pantetheine phosphate adenylyltransferase; dephospho-coenzyme A pyrophosphorylase; 3'-dephospho-CoA pyrophosphorylase | |
| 2.7.7.4 | sulfate adenylyltransferase | False | 458 | 52569 | 30 | 79 | ATP + sulfate = diphosphate + adenylyl sulfate | ATP:sulfate adenylyltransferase | None | ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; ATP-sulfurylase; sulfurylase | |
| 2.7.7.5 | sulfate adenylyltransferase (ADP) | False | 4 | 9 | 0 | 7 | ADP + sulfate = phosphate + adenylyl sulfate | ADP:sulfate adenylyltransferase | None | ADP-sulfurylase; sulfate (adenosine diphosphate) adenylyltransferase; adenosine diphosphate sulfurylase | |
| 2.7.7.6 | DNA-directed RNA polymerase | False | 3981 | 409846 | 1062 | 95 | nucleoside triphosphate + RNAn = diphosphate + RNAn+1 | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | None | RNA polymerase; RNA nucleotidyltransferase (DNA-directed); RNA polymerase I; RNA polymerase II; RNA polymerase III; C RNA formation factors; deoxyribonucleic acid-dependent ribonucleic acid polymerase; DNA-dependent ribonucleate nucleotidyltransferase; DNA-dependent RNA nucleotidyltransferase; DNA-dependent RNA polymerase; ribonucleate nucleotidyltransferase; ribonucleate polymerase; C ribonucleic acid formation factors; ribonucleic acid nucleotidyltransferase; ribonucleic acid polymerase; ribonucleic acid transcriptase; ribonucleic polymerase; ribonucleic transcriptase; RNA nucleotidyltransferase; RNA transcriptase; transcriptase; RNA nucleotidyltransferase I | |
| 2.7.7.7 | DNA-directed DNA polymerase | False | 1057 | 388834 | 1881 | 132 | a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 | 2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | None | DNA polymerase I; DNA polymerase II; DNA polymerase III; DNA polymerase alpha; DNA polymerase beta; DNA polymerase gamma; DNA nucleotidyltransferase (DNA-directed); deoxyribonucleate nucleotidyltransferase; deoxynucleate polymerase; deoxyribonucleic acid duplicase; deoxyribonucleic acid polymerase; deoxyribonucleic duplicase; deoxyribonucleic polymerase; deoxyribonucleic polymerase I; DNA duplicase; DNA nucleotidyltransferase; DNA polymerase; DNA replicase; DNA-dependent DNA polymerase; duplicase; Klenow fragment; sequenase; Taq DNA polymerase; Taq Pol I; Tca DNA polymerase | |
| 2.7.7.8 | polyribonucleotide nucleotidyltransferase | False | 783 | 43161 | 24 | 56 | RNAn+1 + phosphate = RNAn + a nucleoside diphosphate | polyribonucleotide:phosphate nucleotidyltransferase | None | polynucleotide phosphorylase; PNPase (ambiguous); nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide phosphorylase | |
| 2.7.7.9 | UTP---glucose-1-phosphate uridylyltransferase | False | 74 | 46256 | 46 | 78 | UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose | UTP:alpha-D-glucose-1-phosphate uridylyltransferase | None | UDP glucose pyrophosphorylase; glucose-1-phosphate uridylyltransferase; UDPG phosphorylase; UDPG pyrophosphorylase; uridine 5'-diphosphoglucose pyrophosphorylase; uridine diphosphoglucose pyrophosphorylase; uridine diphosphate-D-glucose pyrophosphorylase; uridine-diphosphate glucose pyrophosphorylase | |
| 2.7.7.10 | UTP---hexose-1-phosphate uridylyltransferase | False | 0 | 146 | 3 | 10 | UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose | UTP:alpha-D-hexose-1-phosphate uridylyltransferase | None | galactose-1-phosphate uridylyltransferase; galactose 1-phosphate uridylyltransferase; alpha-D-galactose 1-phosphate uridylyltransferase; galactose 1-phosphate uridyltransferase; UDPgalactose pyrophosphorylase; uridine diphosphate galactose pyrophosphorylase; uridine diphosphogalactose pyrophosphorylase | |
| 2.7.7.11 | UTP---xylose-1-phosphate uridylyltransferase | True | 0 | 0 | 0 | 1 | UTP + alpha-D-xylose 1-phosphate = diphosphate + UDP-xylose | UTP:alpha-D-xylose-1-phosphate uridylyltransferase | None | xylose-1-phosphate uridylyltransferase; uridylyltransferase, xylose 1-phosphate; UDP-xylose pyrophosphorylase; uridine diphosphoxylose pyrophosphorylase; xylose 1-phosphate uridylyltransferase | |
| 2.7.7.12 | UDP-glucose---hexose-1-phosphate uridylyltransferase | False | 54 | 17470 | 6 | 20 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose | UDP-alpha-D-glucose:alpha-D-galactose-1-phosphate uridylyltransferase | None | uridyl transferase; hexose-1-phosphate uridylyltransferase; uridyltransferase; hexose 1-phosphate uridyltransferase; UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase | |
| 2.7.7.13 | mannose-1-phosphate guanylyltransferase | False | 62 | 21875 | 10 | 31 | GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose | GTP:alpha-D-mannose-1-phosphate guanylyltransferase | None | GTP-mannose-1-phosphate guanylyltransferase; PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase); GDP-mannose pyrophosphorylase; guanosine 5'-diphospho-D-mannose pyrophosphorylase; guanosine diphosphomannose pyrophosphorylase; guanosine triphosphate-mannose 1-phosphate guanylyltransferase; mannose 1-phosphate guanylyltransferase (guanosine triphosphate) | |
| 2.7.7.14 | ethanolamine-phosphate cytidylyltransferase | False | 9 | 5926 | 2 | 9 | CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine | CTP:ethanolamine-phosphate cytidylyltransferase | None | phosphorylethanolamine transferase; ET; CTP-phosphoethanolamine cytidylyltransferase; phosphoethanolamine cytidylyltransferase; ethanolamine phosphate cytidylyltransferase | |
| 2.7.7.15 | choline-phosphate cytidylyltransferase | False | 15 | 6638 | 33 | 15 | CTP + phosphocholine = diphosphate + CDP-choline | CTP:phosphocholine cytidylyltransferase | None | phosphorylcholine transferase; CDP-choline pyrophosphorylase; CDP-choline synthetase; choline phosphate cytidylyltransferase; CTP-phosphocholine cytidylyltransferase; CTP:phosphorylcholine cytidylyltransferase; cytidine diphosphocholine pyrophosphorylase; phosphocholine cytidylyltransferase; phosphorylcholine cytidylyltransferase; phosphorylcholine:CTP cytidylyltransferase | |
| 2.7.7.18 | nicotinate-nucleotide adenylyltransferase | False | 412 | 43942 | 35 | 18 | ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+ | ATP:beta-nicotinate-D-ribonucleotide adenylyltransferase | None | deamido-NAD+ pyrophosphorylase; nicotinate mononucleotide adenylyltransferase; deamidonicotinamide adenine dinucleotide pyrophosphorylase; NaMN-ATase; nicotinic acid mononucleotide adenylyltransferase | |
| 2.7.7.19 | polynucleotide adenylyltransferase | False | 137 | 31243 | 56 | 35 | ATP + RNAn = diphosphate + RNAn+1 | ATP:polynucleotide adenylyltransferase | None | NTP polymerase; RNA adenylating enzyme; AMP polynucleotidylexotransferase; ATP-polynucleotide adenylyltransferase; ATP:polynucleotidylexotransferase; poly(A) polymerase; poly(A) synthetase; polyadenylate nucleotidyltransferase; polyadenylate polymerase; polyadenylate synthetase; polyadenylic acid polymerase; polyadenylic polymerase; terminal riboadenylate transferase; poly(A) hydrolase; RNA formation factors, PF1; adenosine triphosphate:ribonucleic acid adenylyltransferase | |
| 2.7.7.22 | mannose-1-phosphate guanylyltransferase (GDP) | False | 0 | 531 | 0 | 6 | GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose | GDP:alpha-D-mannose-1-phosphate guanylyltransferase | None | GDP mannose phosphorylase; mannose 1-phosphate (guanosine diphosphate) guanylyltransferase; GDP mannose phosphorylase; GDP-mannose 1-phosphate guanylyltransferase; guanosine diphosphate-mannose 1-phosphate guanylyltransferase; guanosine diphosphomannose phosphorylase; mannose 1-phosphate guanylyltransferase; GDP:D-mannose-1-phosphate guanylyltransferase | |
| 2.7.7.23 | UDP-N-acetylglucosamine diphosphorylase | False | 614 | 33396 | 54 | 28 | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine | UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase | None | UDP-N-acetylglucosamine pyrophosphorylase; uridine diphosphoacetylglucosamine pyrophosphorylase; UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase; UDP-GlcNAc pyrophosphorylase; GlmU uridylyltransferase; Acetylglucosamine 1-phosphate uridylyltransferase; UDP-acetylglucosamine pyrophosphorylase; uridine diphosphate-N-acetylglucosamine pyrophosphorylase; uridine diphosphoacetylglucosamine phosphorylase; acetylglucosamine 1-phosphate uridylyltransferase | |
| 2.7.7.24 | glucose-1-phosphate thymidylyltransferase | False | 25 | 37660 | 50 | 27 | dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose | dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase | None | glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase | |
| 2.7.7.72 | CCA tRNA nucleotidyltransferase | False | 363 | 17954 | 21 | 25 | a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate (overall reaction);;(1a) a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate;;(1b) a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate;;(1c) a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate | CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase | None | CCA-adding enzyme; tRNA adenylyltransferase; tRNA cytidylyltransferase; tRNA CCA-pyrophosphorylase; tRNA-nucleotidyltransferase; transfer-RNA nucleotidyltransferase; transfer ribonucleic acid nucleotidyl transferase; CTP(ATP):tRNA nucleotidyltransferase; transfer ribonucleate adenylyltransferase; transfer ribonucleate adenyltransferase; transfer RNA adenylyltransferase; transfer ribonucleate nucleotidyltransferase; ATP (CTP):tRNA nucleotidyltransferase; ribonucleic cytidylic cytidylic adenylic pyrophosphorylase; transfer ribonucleic adenylyl (cytidylyl) transferase; transfer ribonucleic-terminal trinucleotide nucleotidyltransferase; transfer ribonucleate cytidylyltransferase; ribonucleic cytidylyltransferase; -C-C-A pyrophosphorylase; ATP(CTP)-tRNA nucleotidyltransferase; tRNA adenylyl(cytidylyl)transferase; CTP:tRNA cytidylyltransferase | |
| 2.7.7.27 | glucose-1-phosphate adenylyltransferase | False | 319 | 29097 | 20 | 80 | ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-alpha-D-glucose | ATP:alpha-D-glucose-1-phosphate adenylyltransferase | None | ADP glucose pyrophosphorylase; glucose 1-phosphate adenylyltransferase; adenosine diphosphate glucose pyrophosphorylase; adenosine diphosphoglucose pyrophosphorylase; ADP-glucose pyrophosphorylase; ADP-glucose synthase; ADP-glucose synthetase; ADPG pyrophosphorylase; ADP:alpha-D-glucose-1-phosphate adenylyltransferase | |
| 2.7.7.28 | nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase | False | 0 | 1 | 0 | 2 | nucleoside triphosphate + alpha-D-aldose 1-phosphate = diphosphate + NDP-hexose | NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase | None | NDP hexose pyrophosphorylase; hexose 1-phosphate nucleotidyltransferase; hexose nucleotidylating enzyme; nucleoside diphosphohexose pyrophosphorylase; hexose-1-phosphate guanylyltransferase; GTP:alpha-D-hexose-1-phosphate guanylyltransferase; GDP hexose pyrophosphorylase; guanosine diphosphohexose pyrophosphorylase; nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase; NTP:hexose-1-phosphate nucleotidyltransferase | |
| 2.7.7.30 | fucose-1-phosphate guanylyltransferase | False | 3 | 20 | 0 | 11 | GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose | GTP:beta-L-fucose-1-phosphate guanylyltransferase | None | GDP fucose pyrophosphorylase; guanosine diphosphate L-fucose pyrophosphorylase; GDP-L-fucose pyrophosphorylase; GDP-fucose pyrophosphorylase; GTP:L-fucose-1-phosphate guanylyltransferase | |
| 2.7.7.31 | DNA nucleotidylexotransferase | False | 10 | 649 | 37 | 14 | 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 | 2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidylexotransferase | None | terminal deoxyribonucleotidyltransferase; terminal addition enzyme; addase; deoxynucleotidyl terminal transferase; deoxyribonucleic acid nucleotidyltransferase; deoxyribonucleic nucleotidyltransferase; terminal deoxynucleotide transferase; TdT | |
| 2.7.7.32 | galactose-1-phosphate thymidylyltransferase | True | 0 | 0 | 0 | 1 | dTTP + alpha-D-galactose 1-phosphate = diphosphate + dTDP-galactose | dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase | None | dTDP galactose pyrophosphorylase; galactose 1-phosphate thymidylyl transferase; thymidine diphosphogalactose pyrophosphorylase; thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase | |
| 2.7.7.33 | glucose-1-phosphate cytidylyltransferase | False | 3 | 7993 | 2 | 5 | CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose | CTP:alpha-D-glucose-1-phosphate cytidylyltransferase | None | CDP glucose pyrophosphorylase; cytidine diphosphoglucose pyrophosphorylase; cytidine diphosphate glucose pyrophosphorylase; cytidine diphosphate-D-glucose pyrophosphorylase; CTP:D-glucose-1-phosphate cytidylyltransferase | |
| 2.7.7.34 | glucose-1-phosphate guanylyltransferase | True | 0 | 0 | 0 | 11 | GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose | GTP:alpha-D-glucose-1-phosphate guanylyltransferase | None | GDP glucose pyrophosphorylase; guanosine diphosphoglucose pyrophosphorylase | |
| 2.7.7.35 | ADP ribose phosphorylase | True | 0 | 0 | 0 | 2 | ADP + D-ribose 5-phosphate = phosphate + ADP-D-ribose | ADP:D-ribose-5-phosphate adenylyltransferase | None | ; ribose-5-phosphate adenylyltransferase (ambiguous); adenosine diphosphoribose phosphorylase (ambiguous) | |
| 2.7.7.36 | aldose-1-phosphate adenylyltransferase | True | 0 | 0 | 0 | 1 | ADP + alpha-D-aldose 1-phosphate = phosphate + ADP-aldose | ADP:alpha-D-aldose-1-phosphate adenylyltransferase | None | sugar-1-phosphate adenylyltransferase; ADPaldose phosphorylase; adenosine diphosphosugar phosphorylase; ADP sugar phosphorylase; adenosine diphosphate glucose:orthophosphate adenylyltransferase; ADP:aldose-1-phosphate adenylyltransferase | |
| 2.7.7.37 | aldose-1-phosphate nucleotidyltransferase | False | 0 | 10 | 0 | 3 | NDP + alpha-D-aldose 1-phosphate = phosphate + NDP-aldose | NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase | None | sugar-1-phosphate nucleotidyltransferase; NDPaldose phosphorylase; glucose 1-phosphate inosityltransferase; NDP sugar phosphorylase; nucleoside diphosphosugar phosphorylase; sugar phosphate nucleotidyltransferase; nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase; sugar nucleotide phosphorylase; NDP:aldose-1-phosphate nucleotidyltransferase | |
| 2.7.7.38 | 3-deoxy-manno-octulosonate cytidylyltransferase | False | 380 | 20962 | 22 | 30 | CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate | CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase | None | CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase; 2-keto-3-deoxyoctonate cytidylyltransferase; 3-Deoxy-D-manno-octulosonate cytidylyltransferase; CMP-3-deoxy-D-manno-octulosonate synthetase; CMP-KDO synthetase; CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase; cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase | |
| 2.7.7.39 | glycerol-3-phosphate cytidylyltransferase | False | 3 | 1922 | 3 | 10 | CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol | CTP:sn-glycerol-3-phosphate cytidylyltransferase | None | CDP-glycerol pyrophosphorylase; cytidine diphosphoglycerol pyrophosphorylase; cytidine diphosphate glycerol pyrophosphorylase; CTP:glycerol 3-phosphate cytidylyltransferase; Gro-PCT; tagD (gene name); tarD (gene name) | |
| 2.7.7.40 | D-ribitol-5-phosphate cytidylyltransferase | False | 49 | 1737 | 6 | 10 | CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol | CTP:D-ribitol-5-phosphate cytidylyltransferase | None | CDP ribitol pyrophosphorylase; cytidine diphosphate ribitol pyrophosphorylase; ribitol 5-phosphate cytidylyltransferase; cytidine diphosphoribitol pyrophosphorylase | |
| 2.7.7.41 | phosphatidate cytidylyltransferase | False | 70 | 54261 | 5 | 29 | CTP + phosphatidate = diphosphate + CDP-diacylglycerol | CTP:phosphatidate cytidylyltransferase | None | CDP diglyceride pyrophosphorylase; CDP-diacylglycerol synthase; CDP-diacylglyceride synthetase; cytidine diphosphoglyceride pyrophosphorylase; phosphatidate cytidyltransferase; phosphatidic acid cytidylyltransferase; CTP:1,2-diacylglycerophosphate-cytidyl transferase; CTP-diacylglycerol synthetase; DAG synthetase; CDP-DG | |
| 2.7.7.42 | [glutamine synthetase] adenylyltransferase | False | 136 | 15866 | 2 | 8 | ATP + [glutamine synthetase]-L-tyrosine = diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine | ATP:[glutamine synthetase]-L-tyrosine adenylyltransferase | None | glutamine-synthetase adenylyltransferase; ATP:glutamine synthetase adenylyltransferase; adenosine triphosphate:glutamine synthetase adenylyltransferase; ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyltransferase; ATP:[L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine adenylyltransferase; [glutamate---ammonia-ligase] adenylyltransferase | |
| 2.7.7.43 | N-acylneuraminate cytidylyltransferase | False | 16 | 3863 | 10 | 25 | CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate | CTP:N-acylneuraminate cytidylyltransferase | None | CMP-sialate pyrophosphorylase; CMP-sialate synthase; cytidine 5'-monophosphosialic acid synthetase; CMP-Neu5Ac synthetase; CMP-NeuAc synthetase; acylneuraminate cytidyltransferase; CMP-N-acetylneuraminate synthetase; CMP-N-acetylneuraminate synthase; CMP-N-acetylneuraminic acid synthase; CMP-NANA synthetase; CMP-sialate synthetase; CMP-sialic synthetase; cytidine 5'-monophospho-N-acetylneuraminic acid synthetase; cytidine 5-monophosphate N-acetylneuraminic acid synthetase; cytidine monophosphosialic acid synthetase; cytidine monophosphoacetylneuraminic synthetase; cytidine monophosphosialate pyrophosphorylase; cytidine monophosphosialate synthetase; acetylneuraminate cytidylyltransferase | |
| 2.7.7.44 | glucuronate-1-phosphate uridylyltransferase | True | 0 | 0 | 0 | 5 | UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-alpha-D-glucuronate | UTP:1-phospho-alpha-D-glucuronate uridylyltransferase | None | UDP-glucuronate pyrophosphorylase; UDP-D-glucuronic acid pyrophosphorylase; UDP-glucuronic acid pyrophosphorylase; uridine diphosphoglucuronic pyrophosphorylase | |
| 2.7.7.45 | guanosine-triphosphate guanylyltransferase | True | 0 | 0 | 0 | 4 | 2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate | GTP:GTP guanylyltransferase | None | diguanosine tetraphosphate synthetase; GTP-GTP guanylyltransferase; Gp4G synthetase; guanosine triphosphate-guanose triphosphate guanylyltransferase | |
| 2.7.7.46 | gentamicin 2''-nucleotidyltransferase | False | 3 | 6 | 3 | 4 | nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin | NTP:gentamicin 2''-nucleotidyltransferase | None | gentamicin 2''-adenylyltransferase; aminoglycoside adenylyltransferase; gentamycin 2''-nucleotidyltransferase | |
| 2.7.7.47 | streptomycin 3''-adenylyltransferase | False | 5 | 2816 | 7 | 18 | ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin | ATP:streptomycin 3''-adenylyltransferase | None | streptomycin adenylate synthetase; streptomycin adenyltransferase; streptomycin adenylylase; streptomycin adenylyltransferase; streptomycin-spectinomycin adenylyltransferase; AAD (3''); aminoglycoside 3''-adenylyltransferase | |
| 2.7.7.48 | RNA-directed RNA polymerase | False | 864 | 159225 | 653 | 119 | nucleoside triphosphate + RNAn = diphosphate + RNAn+1 | nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) | None | RNA nucleotidyltransferase (RNA-directed); RNA nucleotidyltransferase (RNA-directed); RNA-dependent ribonucleate nucleotidyltransferase; 3D polymerase; PB1 proteins; PB2 proteins; phage f2 replicase; polymerase L; Q-beta replicase; phage f2 replicase; ribonucleic acid replicase; ribonucleic acid-dependent ribonucleate nucleotidyltransferase; ribonucleic acid-dependent ribonucleic acid polymerase; ribonucleic replicase; ribonucleic synthetase; RNA replicase; RNA synthetase; RNA transcriptase; RNA-dependent ribonucleate nucleotidyltransferase; RDRP; RNA-dependent RNA polymerase; RNA-dependent RNA replicase; transcriptase | |
| 2.7.7.49 | RNA-directed DNA polymerase | False | 326 | 76821 | 511 | 65 | a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 | 2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) | None | DNA nucleotidyltransferase (RNA-directed); reverse transcriptase; revertase; RNA-dependent deoxyribonucleate nucleotidyltransferase; RNA revertase; RNA-dependent DNA polymerase; RNA-instructed DNA polymerase; RT | |
| 2.7.7.50 | mRNA guanylyltransferase | False | 131 | 7097 | 15 | 27 | GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA] | GTP:mRNA guanylyltransferase | None | RNGTT (gene name); CEG1 (gene name); mRNA capping enzyme; messenger RNA guanylyltransferase; Protein lambda2 | |
| 2.7.7.51 | adenylylsulfate---ammonia adenylyltransferase | False | 5 | 0 | 0 | 11 | adenylyl sulfate + NH3 = adenosine 5'-phosphoramidate + sulfate | adenylyl-sulfate:ammonia adenylyltransferase | None | APSAT; adenylylsulfate:ammonia adenylyltransferase | |
| 2.7.7.52 | RNA uridylyltransferase | False | 22 | 5253 | 31 | 12 | UTP + RNAn = diphosphate + RNAn+1 | UTP:RNA uridylyltransferase | None | terminal uridylyltransferase; TUT | |
| 2.7.7.53 | ATP adenylyltransferase | False | 5 | 946 | 5 | 13 | ADP + ATP = phosphate + P1,P4-bis(5'-adenosyl) tetraphosphate | ADP:ATP adenylyltransferase | None | bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming); diadenosinetetraphosphate alphabeta-phosphorylase; adenine triphosphate adenylyltransferase; diadenosine 5',5'"-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming); dinucleoside oligophosphate alphabeta-phosphorylase | |
| 2.7.7.56 | tRNA nucleotidyltransferase | False | 420 | 26104 | 11 | 8 | tRNAn+1 + phosphate = tRNAn + a nucleoside diphosphate | tRNA:phosphate nucleotidyltransferase | None | phosphate-dependent exonuclease; RNase PH; ribonuclease PH | |
| 2.7.7.57 | N-methylphosphoethanolamine cytidylyltransferase | True | 0 | 0 | 0 | 3 | CTP + N-methylethanolamine phosphate = diphosphate + CDP-N-methylethanolamine | CTP:N-methylethanolamine-phosphate cytidylyltransferase | None | monomethylethanolamine phosphate cytidylyltransferase; CTP:P-MEA cytidylyltransferase | |
| 2.7.7.59 | [protein-PII] uridylyltransferase | False | 188 | 19232 | 0 | 12 | UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII] | UTP:[protein-PII] uridylyltransferase | None | PII uridylyl-transferase; uridyl removing enzyme | |
| 2.7.7.60 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | False | 455 | 33074 | 42 | 14 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | None | MEP cytidylyltransferase | |
| 2.7.7.61 | citrate lyase holo-[acyl-carrier protein] synthase | False | 36 | 2929 | 3 | 3 | 2'-(5-triphosphoribosyl)-3'-dephospho-CoA + apo-[citrate (pro-3S)-lyase] = diphosphate + holo-[citrate (pro-3S)-lyase] | 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-[citrate (pro-3S)-lyase] 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase | None | 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase; CitX; holo-ACP synthase (ambiguous); 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase adenylyltransferase; holo-citrate lyase synthase (incorrect); 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase | |
| 2.7.7.62 | adenosylcobinamide-phosphate guanylyltransferase | False | 6 | 19984 | 2 | 8 | GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP | GTP:adenosylcobinamide-phosphate guanylyltransferase | None | CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase | |
| 2.7.8.1 | ethanolaminephosphotransferase | False | 13 | 1473 | 2 | 17 | CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine | CDP-ethanolamine:1,2-diacyl-sn-glycerol ethanolaminephosphotransferase | None | EPT; diacylglycerol ethanolaminephosphotransferase; CDPethanolamine diglyceride phosphotransferase; phosphorylethanolamine-glyceride transferase; CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase | |
| 2.7.8.2 | diacylglycerol cholinephosphotransferase | False | 17 | 2340 | 2 | 34 | CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine | CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase | None | phosphorylcholine-glyceride transferase; alkylacylglycerol cholinephosphotransferase; 1-alkyl-2-acetylglycerol cholinephosphotransferase; cholinephosphotransferase; CPT (ambiguous); alkylacylglycerol choline phosphotransferase; diacylglycerol choline phosphotransferase; 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase; CDP-choline diglyceride phosphotransferase; cytidine diphosphocholine glyceride transferase; cytidine diphosphorylcholine diglyceride transferase; phosphocholine diacylglyceroltransferase; sn-1,2-diacylglycerol cholinephosphotransferase; 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase; CDP choline:1,2-diacylglycerol cholinephosphotransferase; CDP-choline:1,2-diacylglycerol cholinephosphotransferase | |
| 2.7.8.3 | ceramide cholinephosphotransferase | True | 0 | 0 | 0 | 7 | CDP-choline + a ceramide = CMP + sphingomyelin | CDP-choline:N-acylsphingosine cholinephosphotransferase | None | phosphorylcholine-ceramide transferase | |
| 2.7.8.4 | serine-phosphoethanolamine synthase | True | 0 | 0 | 0 | 1 | CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine | CDP-ethanolamine:L-serine ethanolamine phosphotransferase | None | serine ethanolamine phosphate synthetase; serine ethanolamine phosphodiester synthase; serine ethanolaminephosphotransferase; serine-phosphinico-ethanolamine synthase; serinephosphoethanolamine synthase | |
| 2.7.8.5 | CDP-diacylglycerol---glycerol-3-phosphate 1-phosphatidyltransferase | False | 63 | 56608 | 2 | 18 | CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate | CDP-diacylglycerol:sn-glycerol-3-phosphate 1-(3-sn-phosphatidyl)transferase | None | glycerophosphate phosphatidyltransferase; 3-phosphatidyl-1'-glycerol-3'-phosphate synthase; CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDP-diglyceride):sn-glycerol-3-phosphate phosphatidyltransferase; phosphatidylglycerophosphate synthase; phosphatidylglycerolphosphate synthase; PGP synthase; CDP-diacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase; CDP-diacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase; glycerol phosphate phosphatidyltransferase; glycerol 3-phosphate phosphatidyltransferase; phosphatidylglycerol phosphate synthase; phosphatidylglycerol phosphate synthetase; phosphatidylglycerophosphate synthetase; sn-glycerol-3-phosphate phosphatidyltransferase | |
| 2.7.8.6 | undecaprenyl-phosphate galactose phosphotransferase | False | 1 | 1891 | 1 | 5 | UDP-alpha-D-galactose + undecaprenyl phosphate = UMP + alpha-D-galactosyl-diphosphoundecaprenol | UDP-alpha-D-galactose:undecaprenyl-phosphate galactose phosphotransferase | None | poly(isoprenol)-phosphate galactose phosphotransferase; poly(isoprenyl)phosphate galactosephosphatetransferase; undecaprenyl phosphate galactosyl-1-phosphate transferase; UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase | |
| 2.7.8.7 | holo-[acyl-carrier-protein] synthase | False | 595 | 32043 | 40 | 49 | CoA-[4'-phosphopantetheine] + an apo-[acyl-carrier protein] = adenosine 3',5'-bisphosphate + an [acyl-carrier protein] | CoA-[4'-phosphopantetheine]:apo-[acyl-carrier protein] 4'-pantetheinephosphotransferase | None | acyl carrier protein holoprotein (holo-ACP) synthetase; holo-ACP synthetase; coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase; holosynthase; acyl carrier protein synthetase; holo-ACP synthase; PPTase; AcpS; ACPS; acyl carrier protein synthase; P-pant transferase; CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase; CoA-[4'-phosphopantetheine]:apo-[acyl-carrier-protein] 4'-pantetheinephosphotransferase | |
| 2.7.8.8 | CDP-diacylglycerol---serine O-phosphatidyltransferase | False | 17 | 23661 | 5 | 11 | CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine | CDP-diacylglycerol:L-serine 3-sn-phosphatidyltransferase | None | phosphatidylserine synthase; CDPdiglyceride-serine O-phosphatidyltransferase; PS synthase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase; phosphatidylserine synthetase; CDP-diacylglycerol-L-serine O-phosphatidyltransferase; cytidine diphosphoglyceride-serine O-phosphatidyltransferase; CDP-diglyceride-L-serine phosphatidyltransferase; CDP-diglyceride:serine phosphatidyltransferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase; CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase | |
| 2.7.8.9 | phosphomannan mannosephosphotransferase | True | 0 | 0 | 0 | 1 | GDP-mannose + (phosphomannan)n = GMP + (phosphomannan)n+1 | GDP-mannose:phosphomannan mannose phosphotransferase | None | None | |
| 2.7.8.10 | sphingosine cholinephosphotransferase | True | 0 | 0 | 0 | 1 | CDP-choline + sphingosine = CMP + sphingosyl-phosphocholine | CDP-choline:sphingosine cholinephosphotransferase | None | CDP-choline-sphingosine cholinephosphotransferase; phosphorylcholine-sphingosine transferase; cytidine diphosphocholine-sphingosine cholinephosphotransferase; sphingosine choline phosphotransferase | |
| 2.7.8.11 | CDP-diacylglycerol---inositol 3-phosphatidyltransferase | False | 9 | 2541 | 3 | 26 | CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | None | CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase; CDP-DG:inositol transferase; cytidine diphosphodiglyceride-inositol phosphatidyltransferase; CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase; CDP-diglyceride-inositol transferase; cytidine diphosphoglyceride-inositol phosphatidyltransferase; cytidine diphosphoglyceride-inositol transferase | |
| 2.7.8.12 | teichoic acid poly(glycerol phosphate) polymerase | False | 3 | 1075 | 1 | 4 | n CDP-glycerol + 4-O-[(2R)-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-glycerol:4-O-[(2R)-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase | None | teichoic-acid synthase; cytidine diphosphoglycerol glycerophosphotransferase; poly(glycerol phosphate) polymerase; teichoic acid glycerol transferase; glycerophosphate synthetase; CGPTase; CDP-glycerol glycerophosphotransferase (ambiguous); Tag polymerase; CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase; tagF (gene name); tarF (gene name) (ambiguous) | |
| 2.7.8.13 | phospho-N-acetylmuramoyl-pentapeptide-transferase | False | 716 | 39399 | 11 | 13 | UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase | None | MraY transferase; UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase; UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase; phospho-N-acetylmuramoyl pentapeptide translocase; phospho-MurNAc-pentapeptide transferase; phospho-NAc-muramoyl-pentapeptide translocase (UMP); phosphoacetylmuramoylpentapeptide translocase; phosphoacetylmuramoylpentapeptidetransferase | |
| 2.7.8.14 | CDP-ribitol ribitolphosphotransferase | False | 2 | 41 | 1 | 1 | n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase | None | teichoic-acid synthase (ambiguous); polyribitol phosphate synthetase (ambiguous); teichoate synthetase (ambiguous); poly(ribitol phosphate) synthetase (ambiguous); polyribitol phosphate polymerase (ambiguous); teichoate synthase (ambiguous); CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase | |
| 2.7.8.15 | UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminephosphotransferase | False | 11 | 4357 | 6 | 14 | UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol | UDP-N-alpha-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase (configuration-retaining) | None | UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase; UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase; UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase; uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase; chitobiosylpyrophosphoryldolichol synthase; dolichol phosphate N-acetylglucosamine-1-phosphotransferase; UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase; UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase | |
| 2.7.8.17 | UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase | False | 3 | 21 | 2 | 11 | UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose | UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase | None | N-acetylglucosaminylphosphotransferase; UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase; UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase; uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase; uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase; lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase; N-acetylglucosaminyl phosphotransferase; UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase; UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase; UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase; UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase | |
| 2.7.8.18 | UDP-galactose---UDP-N-acetylglucosamine galactose phosphotransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = UMP + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine | UDP-alpha-D-galactose:UDP-N-acetyl-alpha-D-glucosamine galactose phosphotransferase | None | uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase; galactose-1-phosphotransferase; galactosyl phosphotransferase; UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase | |
| 2.7.8.19 | UDP-glucose---glycoprotein glucose phosphotransferase | False | 0 | 3 | 0 | 5 | UDP-glucose + glycoprotein D-mannose = UMP + glycoprotein 6-(D-glucose-1-phospho)-D-mannose | UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase | None | UDP-glucose:glycoprotein glucose-1-phosphotransferase; GlcPTase; Glc-phosphotransferase; uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase | |
| 2.7.8.20 | phosphatidylglycerol---membrane-oligosaccharide glycerophosphotransferase | False | 37 | 1775 | 0 | 2 | phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose | phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase | None | phosphoglycerol transferase; oligosaccharide glycerophosphotransferase; phosphoglycerol transferase I | |
| 2.7.8.21 | membrane-oligosaccharide glycerophosphotransferase | False | 0 | 3 | 0 | 1 | Transfer of a glycerophospho group from one membrane-derived oligosaccharide to another | membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase | None | periplasmic phosphoglycerotransferase; phosphoglycerol cyclase | |
| 2.7.8.22 | 1-alkenyl-2-acylglycerol choline phosphotransferase | False | 6 | 1314 | 0 | 1 | CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine | CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase | None | CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase | |
| 2.7.8.23 | carboxyvinyl-carboxyphosphonate phosphorylmutase | False | 2 | 523 | 1 | 2 | 1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 | 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating) | None | None | |
| 2.7.8.24 | phosphatidylcholine synthase | False | 10 | 3723 | 0 | 16 | CDP-diacylglycerol + choline = CMP + phosphatidylcholine | CDP-diacylglycerol:choline O-phosphatidyltransferase | None | CDP-diglyceride-choline O-phosphatidyltransferase | |
| 2.7.8.26 | adenosylcobinamide-GDP ribazoletransferase | False | 247 | 21521 | 0 | 4 | (1) adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin;;(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate = GMP + adenosylcobalamin 5'-phosphate | adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase | None | CobS; cobalamin synthase; cobalamin-5'-phosphate synthase; cobalamin (5'-phosphate) synthase | |
| 2.7.9.1 | pyruvate, phosphate dikinase | False | 20 | 24060 | 15 | 61 | ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate | ATP:pyruvate, phosphate phosphotransferase | None | pyruvate, orthophosphate dikinase; pyruvate-phosphate dikinase (phosphorylating); pyruvate, phosphate dikinase; pyruvate-inorganic phosphate dikinase; pyruvate-phosphate dikinase; pyruvate-phosphate ligase; pyruvic-phosphate dikinase; pyruvic-phosphate ligase; pyruvate, Pi dikinase; PPDK | |
| 2.7.9.2 | pyruvate, water dikinase | False | 17 | 25906 | 2 | 9 | ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate | ATP:pyruvate, water phosphotransferase | None | phosphoenolpyruvate synthase; pyruvate-water dikinase (phosphorylating); PEP synthetase; phosphoenolpyruvate synthase; phoephoenolpyruvate synthetase; phosphoenolpyruvic synthase; phosphopyruvate synthetase | |
| 2.7.9.3 | selenide, water dikinase | False | 103 | 17634 | 7 | 27 | ATP + selenide + H2O = AMP + selenophosphate + phosphate | ATP:selenide, water phosphotransferase | None | selenophosphate synthase | |
| 2.7.9.4 | alpha-glucan, water dikinase | False | 4 | 71 | 0 | 49 | ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate | ATP:alpha-glucan, water phosphotransferase | None | starch-related R1 protein; GWD | |
| 2.7.9.5 | phosphoglucan, water dikinase | False | 2 | 51 | 0 | 4 | ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate | ATP:phospho-alpha-glucan, water phosphotransferase | None | PWD; OK1 | |
| 2.8.1.1 | thiosulfate sulfurtransferase | False | 149 | 7700 | 30 | 45 | thiosulfate + cyanide = sulfite + thiocyanate | thiosulfate:cyanide sulfurtransferase | None | thiosulfate cyanide transsulfurase; thiosulfate thiotransferase; rhodanese; rhodanase | |
| 2.8.1.2 | 3-mercaptopyruvate sulfurtransferase | False | 9 | 2998 | 4 | 12 | 2-oxo-3-sulfanylpropanoate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin (overall reaction);;(1a) 2-oxo-3-sulfanylpropanoate + [3-mercaptopyruvate sulfurtransferase]-L-cysteine = pyruvate + [3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine;;(1b) [3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine + reduced thioredoxin = hydrogen sulfide + [3-mercaptopyruvate sulfurtransferase]-L-cysteine + oxidized thioredoxin | 2-oxo-3-sulfanylpropanoate:sulfide sulfurtransferase | None | beta-mercaptopyruvate sulfurtransferase; TUM1 (gene name); MPST (gene name); 3-mercaptopyruvate:cyanide sulfurtransferase | |
| 2.8.1.3 | thiosulfate---thiol sulfurtransferase | False | 1 | 0 | 0 | 3 | thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide | thiosulfate:thiol sulfurtransferase | None | glutathione-dependent thiosulfate reductase; sulfane reductase; sulfane sulfurtransferase | |
| 2.8.1.4 | tRNA uracil 4-sulfurtransferase | False | 287 | 13774 | 3 | 7 | ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster | [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine:uracil in tRNA sulfurtransferase | None | thiI (gene name); transfer ribonucleate sulfurtransferase (ambiguous); RNA sulfurtransferase (ambiguous); ribonucleate sulfurtransferase (ambiguous); transfer RNA sulfurtransferase (ambiguous); transfer RNA thiolase (ambiguous); L-cysteine:tRNA sulfurtransferase (incorrect); tRNA sulfurtransferase (ambiguous) | |
| 2.8.1.5 | thiosulfate---dithiol sulfurtransferase | False | 0 | 12 | 0 | 6 | thiosulfate + dithioerythritol = sulfite + 4,5-cis-dihydroxy-1,2-dithiacyclohexane (i.e. oxidized dithioerythritol) + sulfide | thiosulfate:dithioerythritol sulfurtransferase | None | thiosulfate reductase; TSR | |
| 2.8.1.6 | biotin synthase | False | 593 | 25930 | 4 | 12 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin | dethiobiotin:sulfur-(sulfur carrier) sulfurtransferase | None | dethiobiotin:sulfur sulfurtransferase | |
| 3.1.1.85 | pimelyl-[acyl-carrier protein] methyl ester esterase | False | 106 | 4024 | 3 | 6 | pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol | pimeloyl-[acyl-carrier protein] methyl ester hydrolase | None | BioH | |
| 2.8.1.7 | cysteine desulfurase | False | 302 | 73307 | 96 | 35 | L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor (overall reaction);;(1a) L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine;;(1b) [enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor | L-cysteine:acceptor sulfurtransferase | None | IscS; NIFS; NifS; SufS; cysteine desulfurylase | |
| 2.8.2.1 | aryl sulfotransferase | False | 25 | 38 | 13 | 19 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate | 3'-phosphoadenylyl-sulfate:phenol sulfonotransferase | None | phenol sulfotransferase; sulfokinase; 1-naphthol phenol sulfotransferase; 2-naphtholsulfotransferase; 4-nitrocatechol sulfokinase; arylsulfotransferase; dopamine sulfotransferase; p-nitrophenol sulfotransferase; phenol sulfokinase; ritodrine sulfotransferase; PST; 3'-phosphoadenylyl-sulfate:phenol sulfotransferase | |
| 2.8.2.2 | alcohol sulfotransferase | False | 14 | 75 | 3 | 13 | 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate | 3'-phosphoadenylyl-sulfate:alcohol sulfonotransferase | None | hydroxysteroid sulfotransferase; 3beta-hydroxy steroid sulfotransferase; Delta5-3beta-hydroxysteroid sulfokinase; 3-hydroxysteroid sulfotransferase; HST; 5alpha-androstenol sulfotransferase; cholesterol sulfotransferase; dehydroepiandrosterone sulfotransferase; estrogen sulfokinase; estrogen sulfotransferase; steroid alcohol sulfotransferase; steroid sulfokinase; steroid sulfotransferase; sterol sulfokinase; sterol sulfotransferase; alcohol/hydroxysteroid sulfotransferase; 3beta-hydroxysteroid sulfotransferase; 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase | |
| 2.8.2.3 | amine sulfotransferase | False | 2 | 3 | 1 | 5 | 3'-phosphoadenylyl sulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate | 3'-phosphoadenylyl-sulfate:amine N-sulfonotransferase | None | arylamine sulfotransferase; amine N-sulfotransferase; 3'-phosphoadenylyl-sulfate:amine N-sulfotransferase | |
| 2.8.2.4 | estrone sulfotransferase | False | 5 | 19 | 8 | 11 | 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate | 3'-phosphoadenylyl-sulfate:estrone 3-sulfonotransferase | None | 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase; estrogen sulfotransferase; estrogen sulphotransferase; oestrogen sulphotransferase; 3'-phosphoadenylylsulfate:oestrone sulfotransferase; 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase | |
| 2.8.2.5 | chondroitin 4-sulfotransferase | False | 9 | 4 | 0 | 8 | 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate | 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfonotransferase | None | chondroitin sulfotransferase; 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase | |
| 2.8.2.6 | choline sulfotransferase | True | 0 | 0 | 0 | 8 | 3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate | 3'-phosphoadenylyl-sulfate:choline sulfonotransferase | None | choline sulphokinase; 3'-phosphoadenylyl-sulfate:choline sulfotransferase | |
| 2.8.2.7 | UDP-N-acetylgalactosamine-4-sulfate sulfotransferase | True | 0 | 0 | 0 | 3 | 3'-phosphoadenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + UDP-N-acetyl-D-galactosamine 4,6-bissulfate | 3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfonotransferase | None | uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase; uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase; 3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase | |
| 2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase | False | 15 | 4474 | 0 | 11 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfonotransferase | None | heparin N-sulfotransferase; 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase; PAPS:N-desulfoheparin sulfotransferase; PAPS:DSH sulfotransferase; N-HSST; N-heparan sulfate sulfotransferase; heparan sulfate N-deacetylase/N-sulfotransferase; heparan sulfate 2-N-sulfotransferase; heparan sulfate N-sulfotransferase; heparan sulfate sulfotransferase; N-desulfoheparin sulfotransferase; desulfoheparin sulfotransferase; 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase; heparitin sulfotransferase; 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase; 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase | |
| 2.8.2.9 | tyrosine-ester sulfotransferase | False | 0 | 0 | 7 | 4 | 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate | 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfonotransferase | None | aryl sulfotransferase IV; L-tyrosine methyl ester sulfotransferase; 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase | |
| 2.8.2.10 | Renilla-luciferin sulfotransferase | True | 0 | 0 | 0 | 7 | 3'-phosphoadenylyl sulfate + Renilla luciferin = adenosine 3',5'-bisphosphate + luciferyl sulfate | 3'-phosphoadenylyl-sulfate:Renilla luciferin sulfonotransferase | None | luciferin sulfotransferase; luciferin sulfokinase; luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase); 3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase | |
| 2.8.2.11 | galactosylceramide sulfotransferase | False | 3 | 51 | 0 | 7 | 3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate | 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfonotransferase | None | GSase; 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase; galactocerebroside sulfotransferase; galactolipid sulfotransferase; glycolipid sulfotransferase; glycosphingolipid sulfotransferase; 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase | |
| 2.8.2.13 | psychosine sulfotransferase | True | 0 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate | 3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfonotransferase | None | PAPS:psychosine sulphotransferase; 3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase; 3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase | |
| 2.8.2.14 | bile-salt sulfotransferase | False | 6 | 0 | 4 | 9 | (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate;;(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate | 3'-phosphoadenylyl-sulfate:glycolithocholate sulfonotransferase | None | BAST I; bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase; 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase | |
| 2.8.2.15 | steroid sulfotransferase | True | 0 | 0 | 0 | 8 | 3'-phosphoadenylyl sulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate | 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfonotransferase | None | steroid alcohol sulfotransferase; 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase | |
| 2.8.2.16 | thiol sulfotransferase | True | 0 | 0 | 0 | 3 | 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate | 3'-phosphoadenylyl-sulfate:thiol S-sulfonotransferase | None | phosphoadenylylsulfate-thiol sulfotransferase; PAPS sulfotransferase; adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase; 3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase | |
| 2.8.2.17 | chondroitin 6-sulfotransferase | False | 8 | 13 | 0 | 7 | 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate | 3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfonotransferase | None | chondroitin 6-O-sulfotransferase; 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase; terminal 6-sulfotransferase; 3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase | |
| 2.8.2.18 | cortisol sulfotransferase | True | 0 | 0 | 0 | 6 | 3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate | 3'-phosphoadenylyl-sulfate:cortisol 21-sulfonotransferase | None | glucocorticosteroid sulfotransferase; glucocorticoid sulfotransferase; 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase | |
| 2.8.2.19 | triglucosylalkylacylglycerol sulfotransferase | True | 0 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-O-alkyl-2-O-acylglycerol = adenosine 3',5'-bisphosphate + 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-O-alkyl-2-O-acylglycerol | 3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfonotransferase | None | triglucosylmonoalkylmonoacyl sulfotransferase; 3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase | |
| 2.8.2.20 | protein-tyrosine sulfotransferase | False | 15 | 4558 | 5 | 17 | 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate | 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfonotransferase | None | tyrosylprotein sulfotransferase; 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase | |
| 2.8.2.21 | keratan sulfotransferase | False | 10 | 29 | 0 | 5 | 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate | 3'-phosphoadenylyl-sulfate:keratan 6'-sulfonotransferase | None | 3'-phosphoadenylyl keratan sulfotransferase; keratan sulfate sulfotransferase; 3'-phosphoadenylylsulfate:keratan sulfotransferase; 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase | |
| 2.8.2.22 | aryl-sulfate sulfotransferase | False | 2 | 698 | 7 | 10 | an aryl sulfate + a phenol = a phenol + an aryl sulfate | aryl-sulfate:phenol sulfonotransferase | None | arylsulfate-phenol sulfotransferase; arylsulfotransferase (ambiguous); ASST; arylsulfate sulfotransferase; arylsulfate:phenol sulfotransferase; astA (gene name); aryl-sulfate:phenol sulfotransferase | |
| 2.8.2.23 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 | False | 9 | 22 | 6 | 5 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfonotransferase | None | heparin-glucosamine 3-O-sulfotransferase; 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase; glucosaminyl 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase; isoform/isozyme 1 (3-OST-1, HS3ST1); 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase | |
| 2.8.2.24 | aromatic desulfoglucosinolate sulfotransferase | False | 1 | 0 | 0 | 9 | (1) 3'-phosphoadenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-bisphosphate + glucotropeolin;;(2) 3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate = adenosine 3',5'-bisphosphate + glucobrassicin | 3'-phosphoadenylyl-sulfate:aromatic desulfoglucosinolate sulfonotransferase | None | desulfoglucosinolate sulfotransferase (ambiguous); PAPS-desulfoglucosinolate sulfotransferase (ambiguous); 3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase (ambiguous); 3'-phosphoadenylyl-sulfate:aromatic desulfoglucosinolate sulfotransferase | |
| 2.8.2.25 | flavonol 3-sulfotransferase | False | 1 | 1 | 0 | 2 | 3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate | 3'-phosphoadenylyl-sulfate:quercetin 3-sulfonotransferase | None | 3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase | |
| 2.8.2.26 | quercetin-3-sulfate 3'-sulfotransferase | True | 0 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate | 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfonotransferase | None | flavonol 3'-sulfotransferase; 3'-Sulfotransferase; PAPS:flavonol 3-sulfate 3'-sulfotransferase; 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase | |
| 2.8.2.27 | quercetin-3-sulfate 4'-sulfotransferase | False | 1 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,4'-bissulfate | 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfonotransferase | None | flavonol 4'-sulfotransferase; PAPS:flavonol 3-sulfate 4'-sulfotransferase; 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase | |
| 2.8.2.28 | quercetin-3,3'-bissulfate 7-sulfotransferase | True | 0 | 0 | 0 | 3 | 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + quercetin 3,7,3'-trissulfate | 3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfonotransferase | None | flavonol 7-sulfotransferase; 7-sulfotransferase; PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase; 3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase | |
| 2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 | False | 3 | 0 | 0 | 3 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfonotransferase | None | glucosaminyl 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase; isoform/isozyme 2 (3-OST-2, HS3ST2); 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase | |
| 2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 | False | 3 | 15 | 2 | 5 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfonotransferase | None | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase | |
| 2.8.2.31 | petromyzonol sulfotransferase | True | 0 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate | 3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfonotransferase | None | PZ-SULT; 3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase | |
| 2.8.2.32 | scymnol sulfotransferase | True | 0 | 0 | 0 | 5 | 3'-phosphoadenylyl sulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate | 3'-phosphoadenylyl sulfate:5beta-scymnol sulfonotransferase | None | 3'-phosphoadenylyl sulfate:5beta-scymnol sulfotransferase | |
| 2.8.2.33 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase | False | 4 | 44 | 0 | 4 | (1) 3'-phospho-5'-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine;;(2) 3'-phospho-5'-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine | 3'-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfonotransferase | None | GalNAc4S-6ST; CHST15 (gene name); 3'-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase | |
| 2.8.2.34 | glycochenodeoxycholate sulfotransferase | False | 1 | 0 | 0 | 3 | 3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate | 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfonotransferase | None | bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile acid:PAPS:sulfotransferase; BAST; 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase | |
| 2.8.3.1 | propionate CoA-transferase | False | 0 | 114 | 0 | 7 | acetyl-CoA + propanoate = acetate + propanoyl-CoA | acetyl-CoA:propanoate CoA-transferase | None | propionate coenzyme A-transferase; propionate-CoA:lactoyl-CoA transferase; propionyl CoA:acetate CoA transferase; propionyl-CoA transferase | |
| 2.8.3.2 | oxalate CoA-transferase | True | 0 | 0 | 0 | 1 | succinyl-CoA + oxalate = succinate + oxalyl-CoA | succinyl-CoA:oxalate CoA-transferase | None | succinyl---beta-ketoacyl-CoA transferase; oxalate coenzyme A-transferase | |
| 2.8.3.3 | malonate CoA-transferase | True | 0 | 0 | 0 | 2 | acetyl-CoA + malonate = acetate + malonyl-CoA | acetyl-CoA:malonate CoA-transferase | None | malonate coenzyme A-transferase | |
| 2.8.3.5 | 3-oxoacid CoA-transferase | False | 27 | 7957 | 16 | 20 | succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA | succinyl-CoA:3-oxo-acid CoA-transferase | None | 3-oxoacid coenzyme A-transferase; 3-ketoacid CoA-transferase; 3-ketoacid coenzyme A transferase; 3-oxo-CoA transferase; 3-oxoacid CoA dehydrogenase; acetoacetate succinyl-CoA transferase; acetoacetyl coenzyme A-succinic thiophorase; succinyl coenzyme A-acetoacetyl coenzyme A-transferase; succinyl-CoA transferase | |
| 2.8.3.6 | 3-oxoadipate CoA-transferase | False | 7 | 6087 | 0 | 9 | succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA | succinyl-CoA:3-oxoadipate CoA-transferase | None | 3-oxoadipate coenzyme A-transferase; 3-oxoadipate succinyl-CoA transferase | |
| 2.8.3.8 | acetate CoA-transferase | False | 6 | 4284 | 2 | 16 | acyl-CoA + acetate = a fatty acid anion + acetyl-CoA | acyl-CoA:acetate CoA-transferase | None | acetate coenzyme A-transferase; butyryl CoA:acetate CoA transferase; butyryl coenzyme A transferase | |
| 2.8.3.9 | butyrate---acetoacetate CoA-transferase | False | 2 | 655 | 1 | 5 | butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA | butanoyl-CoA:acetoacetate CoA-transferase | None | butyryl coenzyme A-acetoacetate coenzyme A-transferase; butyryl-CoA-acetoacetate CoA-transferase | |
| 2.8.3.10 | citrate CoA-transferase | False | 4 | 4039 | 0 | 1 | acetyl-CoA + citrate = acetate + (3S)-citryl-CoA | acetyl-CoA:citrate CoA-transferase | None | None | |
| 2.8.3.11 | citramalate CoA-transferase | False | 0 | 12 | 0 | 2 | acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA | acetyl-CoA:citramalate CoA-transferase | None | None | |
| 2.8.3.12 | glutaconate CoA-transferase | False | 2 | 809 | 0 | 1 | acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA | acetyl-CoA:(E)-glutaconate CoA-transferase | None | None | |
| 2.8.3.13 | succinate---hydroxymethylglutarate CoA-transferase | False | 3 | 36 | 2 | 2 | succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA | succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase | None | hydroxymethylglutarate coenzyme A-transferase; dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase | |
| 2.8.3.14 | 5-hydroxypentanoate CoA-transferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxypentanoyl-CoA | acetyl-CoA:5-hydroxypentanoate CoA-transferase | None | 5-hydroxyvalerate CoA-transferase; 5-hydroxyvalerate coenzyme A transferase | |
| 2.8.3.15 | succinyl-CoA:(R)-benzylsuccinate CoA-transferase | False | 2 | 620 | 0 | 2 | succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA | succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase | None | benzylsuccinate CoA-transferase | |
| 2.8.3.16 | formyl-CoA transferase | False | 40 | 6759 | 12 | 39 | formyl-CoA + oxalate = formate + oxalyl-CoA | formyl-CoA:oxalate CoA-transferase | None | formyl-coenzyme A transferase; formyl-CoA oxalate CoA-transferase | |
| 2.8.3.17 | 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase | False | 1 | 285 | 0 | 1 | (1) (E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA;;(2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA;;(3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA | 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase | None | FldA; cinnamoyl-CoA:phenyllactate CoA-transferase | |
| 2.8.4.1 | coenzyme-B sulfoethylthiotransferase | False | 38 | 6750 | 25 | 40 | methyl-CoM + CoB = CoM-S-S-CoB + methane | methyl-CoM:CoB S-(2-sulfoethyl)thiotransferase | None | methyl-CoM reductase; methyl coenzyme M reductase | |
| 2.9.1.1 | L-seryl-tRNASec selenium transferase | False | 127 | 12335 | 9 | 10 | L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate | selenophosphate:L-seryl-tRNASec selenium transferase | None | L-selenocysteinyl-tRNASel synthase; L-selenocysteinyl-tRNASec synthase selenocysteine synthase; cysteinyl-tRNASec-selenium transferase; cysteinyl-tRNASec-selenium transferase | |
| 3.1.1.1 | carboxylesterase | False | 180 | 7218 | 122 | 114 | a carboxylic ester + H2O = an alcohol + a carboxylate | carboxylic-ester hydrolase | None | ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; alpha-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase | |
| 3.1.1.2 | arylesterase | False | 20 | 2814 | 20 | 40 | a phenyl acetate + H2O = a phenol + acetate | aryl-ester hydrolase | None | A-esterase (ambiguous); paraoxonase (ambiguous); aromatic esterase | |
| 3.1.1.3 | triacylglycerol lipase | False | 202 | 12454 | 227 | 155 | triacylglycerol + H2O = diacylglycerol + a carboxylate | triacylglycerol acylhydrolase | None | lipase (ambiguous); butyrinase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; PNLIP (gene name); LIPF (gene name) | |
| 3.1.1.4 | phospholipase A2 | False | 595 | 22975 | 292 | 117 | phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate | phosphatidylcholine 2-acylhydrolase | None | lecithinase A; phosphatidase; phosphatidolipase; phospholipase A | |
| 3.1.1.5 | lysophospholipase | False | 123 | 12564 | 11 | 41 | 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate | 2-lysophosphatidylcholine acylhydrolase | None | lecithinase B; lysolecithinase; phospholipase B; lysophosphatidase; lecitholipase; phosphatidase B; lysophosphatidylcholine hydrolase; lysophospholipase A1; lysophopholipase L2; lysophospholipase transacylase; neuropathy target esterase; NTE; NTE-LysoPLA; NTE-lysophospholipase | |
| 3.1.1.6 | acetylesterase | False | 16 | 100 | 8 | 52 | an acetic ester + H2O = an alcohol + acetate | acetic-ester acetylhydrolase | None | C-esterase (in animal tissues); acetic ester hydrolase; chloroesterase; p-nitrophenyl acetate esterase; Citrus acetylesterase | |
| 3.1.1.7 | acetylcholinesterase | False | 26 | 523 | 304 | 108 | acetylcholine + H2O = choline + acetate | acetylcholine acetylhydrolase | None | true cholinesterase; choline esterase I; cholinesterase; acetylthiocholinesterase; acetylcholine hydrolase; acetyl.beta-methylcholinesterase; AcCholE | |
| 3.1.1.8 | cholinesterase | False | 14 | 60 | 89 | 77 | an acylcholine + H2O = choline + a carboxylate | acylcholine acylhydrolase | None | pseudocholinesterase; butyrylcholine esterase; non-specific cholinesterase; choline esterase II (unspecific); benzoylcholinesterase; choline esterase; butyrylcholinesterase; propionylcholinesterase; BtChoEase | |
| 3.1.1.10 | tropinesterase | False | 1 | 666 | 0 | 9 | atropine + H2O = tropine + tropate | atropine acylhydrolase | None | tropine esterase; atropinase; atropine esterase | |
| 3.1.1.11 | pectinesterase | False | 104 | 27820 | 15 | 153 | pectin + n H2O = n methanol + pectate | pectin pectylhydrolase | None | pectin demethoxylase; pectin methoxylase; pectin methylesterase; pectase; pectin methyl esterase; pectinoesterase | |
| 3.1.1.13 | sterol esterase | False | 22 | 506 | 11 | 25 | a steryl ester + H2O = a sterol + a fatty acid | steryl-ester acylhydrolase | None | cholesterol esterase; cholesteryl ester synthase; triterpenol esterase; cholesteryl esterase; cholesteryl ester hydrolase; sterol ester hydrolase; cholesterol ester hydrolase; cholesterase; acylcholesterol lipase | |
| 3.1.1.14 | chlorophyllase | False | 7 | 153 | 0 | 168 | chlorophyll + H2O = phytol + chlorophyllide | chlorophyll chlorophyllidohydrolase | None | CLH; Chlase | |
| 3.1.1.15 | L-arabinonolactonase | False | 2 | 426 | 0 | 5 | L-arabinono-1,4-lactone + H2O = L-arabinonate | L-arabinono-1,4-lactone lactonohydrolase | None | None | |
| 3.1.1.17 | gluconolactonase | False | 13 | 4423 | 16 | 19 | D-glucono-1,5-lactone + H2O = D-gluconate | D-glucono-1,5-lactone lactonohydrolase | None | lactonase; aldonolactonase; glucono-delta-lactonase; gulonolactonase | |
| 3.1.1.19 | uronolactonase | True | 0 | 0 | 0 | 7 | D-glucurono-6,2-lactone + H2O = D-glucuronate | D-glucurono-6,2-lactone lactonohydrolase | None | glucuronolactonase | |
| 3.1.1.20 | tannase | False | 2 | 36 | 2 | 79 | digallate + H2O = 2 gallate | tannin acylhydrolase | None | tannase S; tannin acetylhydrolase | |
| 3.1.1.22 | hydroxybutyrate-dimer hydrolase | False | 27 | 398 | 0 | 8 | (R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate | (R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase | None | D-(-)-3-hydroxybutyrate-dimer hydrolase | |
| 3.1.1.23 | acylglycerol lipase | False | 42 | 3622 | 29 | 15 | Hydrolyses glycerol monoesters of long-chain fatty acids | glycerol-ester acylhydrolase | None | monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase | |
| 3.1.1.24 | 3-oxoadipate enol-lactonase | False | 2 | 6055 | 1 | 7 | 3-oxoadipate enol-lactone + H2O = 3-oxoadipate | 4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase | None | carboxymethylbutenolide lactonase; beta-ketoadipic enol-lactone hydrolase; 3-ketoadipate enol-lactonase; 3-oxoadipic enol-lactone hydrolase; beta-ketoadipate enol-lactone hydrolase | |
| 3.1.1.25 | 1,4-lactonase | False | 2 | 20 | 3 | 13 | a 1,4-lactone + H2O = a 4-hydroxyacid | 1,4-lactone hydroxyacylhydrolase | None | gamma-lactonase | |
| 3.1.1.26 | galactolipase | False | 11 | 29 | 0 | 48 | 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates | 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase | None | galactolipid lipase; polygalactolipase; galactolipid acylhydrolase | |
| 3.1.1.27 | 4-pyridoxolactonase | False | 1 | 46 | 3 | 2 | 4-pyridoxolactone + H2O = 4-pyridoxate | 4-pyridoxolactone lactonohydrolase | None | None | |
| 3.1.1.28 | acylcarnitine hydrolase | False | 2 | 0 | 1 | 6 | O-acylcarnitine + H2O = a fatty acid + L-carnitine | O-acylcarnitine acylhydrolase | None | high activity acylcarnitine hydrolase; HACH; carnitine ester hydrolase; palmitoylcarnitine hydrolase; palmitoyl-L-carnitine hydrolase; long-chain acyl-L-carnitine hydrolase; palmitoyl carnitine hydrolase | |
| 3.1.1.29 | peptidyl-tRNA hydrolase | False | 780 | 66710 | 155 | 24 | N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA | peptidyl-tRNA peptidylhydrolase | None | aminoacyl-transfer ribonucleate hydrolase; N-substituted aminoacyl transfer RNA hydrolase; aminoacyl-tRNA hydrolase; PTH1 (gene name); PTH2 (gene name); pth (gene name); spoVC (gene name); PTRH1 (gene name); PTRH2 (gene name) | |
| 3.1.1.30 | D-arabinonolactonase | False | 0 | 2 | 0 | 1 | D-arabinono-1,4-lactone + H2O = D-arabinonate | D-arabinono-1,4-lactone lactonohydrolase | None | None | |
| 3.1.1.31 | 6-phosphogluconolactonase | False | 130 | 26240 | 11 | 17 | 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate | 6-phospho-D-glucono-1,5-lactone lactonohydrolase | None | phosphogluconolactonase; 6-PGL | |
| 3.1.1.32 | phospholipase A1 | False | 89 | 10122 | 12 | 48 | phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | phosphatidylcholine 1-acylhydrolase | None | None | |
| 3.1.1.33 | 6-acetylglucose deacetylase | True | 0 | 0 | 0 | 1 | 6-acetyl-D-glucose + H2O = D-glucose + acetate | 6-acetyl-D-glucose acetylhydrolase | None | 6-O-acetylglucose deacetylase | |
| 3.1.1.34 | lipoprotein lipase | False | 11 | 1279 | 6 | 20 | triacylglycerol + H2O = diacylglycerol + a carboxylate | triacylglycerol acylhydrolase (lipoprotein-dependent) | None | clearing factor lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; hepatic triacylglycerol lipase; LIPC (gene name); LPL (gene name); triacylglycero-protein acylhydrolase | |
| 3.1.1.35 | dihydrocoumarin hydrolase | False | 1 | 0 | 1 | 8 | dihydrocoumarin + H2O = melilotate | dihydrocoumarin lactonohydrolase | None | None | |
| 3.1.1.36 | limonin-D-ring-lactonase | True | 0 | 0 | 0 | 4 | limonoate D-ring-lactone + H2O = limonoate | limonoate-D-ring-lactone lactonohydrolase | None | limonin-D-ring-lactone hydrolase; limonin lactone hydrolase | |
| 3.1.1.37 | steroid-lactonase | True | 0 | 0 | 0 | 1 | testololactone + H2O = testolate | testololactone lactonohydrolase | None | None | |
| 3.1.1.38 | triacetate-lactonase | True | 0 | 0 | 0 | 1 | triacetate lactone + H2O = triacetate | triacetolactone lactonohydrolase | None | triacetic lactone hydrolase; triacetic acid lactone hydrolase; TAL hydrolase; triacetate lactone hydrolase | |
| 3.1.1.39 | actinomycin lactonase | True | 0 | 0 | 0 | 13 | actinomycin + H2O = actinomycinic monolactone | actinomycin lactonohydrolase | None | None | |
| 3.1.1.40 | orsellinate-depside hydrolase | True | 0 | 0 | 0 | 2 | orsellinate depside + H2O = 2 orsellinate | orsellinate-depside hydrolase | None | lecanorate hydrolase | |
| 3.1.1.41 | cephalosporin-C deacetylase | False | 2 | 674 | 8 | 12 | cephalosporin C + H2O = deacetylcephalosporin C + acetate | cephalosporin-C acetylhydrolase | None | cephalosporin C acetyl-hydrolase; cephalosporin C acetylase; cephalosporin acetylesterase; cephalosporin C acetylesterase; cephalosporin C acetyl-esterase; cephalosporin C deacetylase | |
| 3.1.1.42 | chlorogenate hydrolase | False | 2 | 9 | 0 | 13 | chlorogenate + H2O = caffeate + quinate | chlorogenate hydrolase | None | chlorogenase; chlorogenic acid esterase | |
| 3.1.1.43 | alpha-amino-acid esterase | False | 0 | 18 | 3 | 17 | an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol | alpha-amino-acid-ester aminoacylhydrolase | None | alpha-amino acid ester hydrolase | |
| 3.1.1.44 | 4-methyloxaloacetate esterase | True | 0 | 0 | 0 | 1 | oxaloacetate 4-methyl ester + H2O = oxaloacetate + methanol | oxaloacetate-4-methyl-ester oxaloacetohydrolase | None | None | |
| 3.1.1.45 | carboxymethylenebutenolidase | False | 17 | 9124 | 18 | 17 | 4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate | 4-carboxymethylenebut-2-en-4-olide lactonohydrolase | None | maleylacetate enol-lactonase; dienelactone hydrolase; carboxymethylene butenolide hydrolase | |
| 3.1.1.46 | deoxylimonate A-ring-lactonase | True | 0 | 0 | 0 | 1 | deoxylimonate + H2O = deoxylimononic acid D-ring-lactone | deoxylimonate A-ring-lactonohydrolase | None | None | |
| 3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase | False | 32 | 8275 | 43 | 15 | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase | None | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase; alkylacetyl-GPC:acetylhydrolase | |
| 3.1.1.48 | fusarinine-C ornithinesterase | True | 0 | 0 | 0 | 4 | N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol | N5-acyl-L-ornithine-ester hydrolase | None | ornithine esterase; 5-N-acyl-L-ornithine-ester hydrolase | |
| 3.1.1.49 | sinapine esterase | False | 1 | 95 | 0 | 9 | sinapoylcholine + H2O = sinapate + choline | sinapoylcholine sinapohydrolase | None | aromatic choline esterase | |
| 3.1.1.50 | wax-ester hydrolase | True | 0 | 0 | 0 | 12 | a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate | wax-ester acylhydrolase | None | jojoba wax esterase; WEH | |
| 3.1.1.51 | phorbol-diester hydrolase | True | 0 | 0 | 0 | 5 | phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate | 12,13-diacylphorbate 12-acylhydrolase | None | diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH | |
| 3.1.1.52 | phosphatidylinositol deacylase | True | 0 | 0 | 0 | 3 | 1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate | 1-phosphatidyl-D-myo-inositol 2-acylhydrolase | None | phosphatidylinositol phospholipase A2; phospholipase A2 | |
| 3.1.1.53 | sialate O-acetylesterase | False | 48 | 1349 | 16 | 29 | N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate | N-acyl-O-acetylneuraminate O-acetylhydrolase | None | N-acetylneuraminate acetyltransferase; sialate 9(4)-O-acetylesterase; sialidase | |
| 3.1.1.54 | acetoxybutynylbithiophene deacetylase | True | 0 | 0 | 0 | 1 | 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene + acetate | 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase | None | acetoxybutynylbithiophene esterase; 5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase | |
| 3.1.1.55 | acetylsalicylate deacetylase | False | 0 | 1 | 0 | 8 | acetylsalicylate + H2O = salicylate + acetate | acetylsalicylate O-acetylhydrolase | None | aspirin esterase; aspirin esterase; acetylsalicylic acid esterase; aspirin hydrolase | |
| 3.1.1.56 | methylumbelliferyl-acetate deacetylase | False | 3 | 17 | 0 | 7 | 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate | 4-methylumbelliferyl-acetate acylhydrolase | None | esterase D | |
| 3.1.1.57 | 2-pyrone-4,6-dicarboxylate lactonase | False | 2 | 291 | 1 | 4 | 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate | 2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase | None | 2-pyrone-4,6-dicarboxylate hydrolase; 2-pyrone-4,6-dicarboxylate lactonohydrolase | |
| 3.1.1.58 | N-acetylgalactosaminoglycan deacetylase | False | 0 | 6 | 0 | 13 | N-acetyl-D-galactosaminoglycan + H2O = D-galactosaminoglycan + acetate | N-acetyl-D-galactosaminoglycan acetylhydrolase | None | polysaccharide deacetylase (misleading); Vi-polysaccharide deacetylase; N-acetyl galactosaminoglycan deacetylase | |
| 3.1.1.59 | juvenile-hormone esterase | False | 5 | 1 | 0 | 36 | (1) juvenile hormone I + H2O = juvenile hormone I acid + methanol;;(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol | methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase | None | JH-esterase; juvenile hormone analog esterase; juvenile hormone carboxyesterase; methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase | |
| 3.1.1.60 | bis(2-ethylhexyl)phthalate esterase | True | 0 | 0 | 0 | 7 | bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexyl phthalate + 2-ethylhexan-1-ol | bis(2-ethylhexyl)phthalate acylhydrolase | None | DEHP esterase | |
| 3.1.1.61 | protein-glutamate methylesterase | False | 237 | 37259 | 5 | 5 | protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol | protein-L-glutamate-O5-methyl-ester acylhydrolase | None | chemotaxis-specific methylesterase; methyl-accepting chemotaxis protein methyl-esterase; CheB methylesterase; methylesterase CheB; protein methyl-esterase; protein carboxyl methylesterase; PME; protein methylesterase; protein-L-glutamate-5-O-methyl-ester acylhydrolase | |
| 3.1.1.63 | 11-cis-retinyl-palmitate hydrolase | True | 0 | 0 | 0 | 3 | 11-cis-retinyl palmitate + H2O = 11-cis-retinol + palmitate | 11-cis-retinyl-palmitate acylhydrolase | None | 11-cis-retinol palmitate esterase; RPH | |
| 3.1.1.64 | retinoid isomerohydrolase | False | 11 | 1047 | 18 | 7 | an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid | all-trans-retinyl ester acylhydrolase, 11-cis retinol-forming | None | all-trans-retinyl-palmitate hydrolase (ambiguous); retinol isomerase (ambiguous); all-trans-retinol isomerase:hydrolase (ambiguous); all-trans-retinylester 11-cis isomerohydrolase; RPE65 (gene name) | |
| 3.1.1.65 | L-rhamnono-1,4-lactonase | False | 1 | 20 | 0 | 6 | L-rhamnono-1,4-lactone + H2O = L-rhamnonate | L-rhamnono-1,4-lactone lactonohydrolase | None | L-rhamno-gamma-lactonase; L-rhamnono-gamma-lactonase; L-rhamnonate dehydratase | |
| 3.1.1.66 | 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase | True | 0 | 0 | 0 | 1 | 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate | 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase | None | diacetoxybutynylbithiophene acetate esterase; 3,4-diacetoxybutinylbithiophene:4-acetate esterase | |
| 3.1.1.67 | fatty-acyl-ethyl-ester synthase | False | 2 | 0 | 0 | 5 | a long-chain-fatty-acyl ethyl ester + H2O = a long-chain-fatty acid + ethanol | long-chain-fatty-acyl-ethyl-ester acylhydrolase | None | FAEES | |
| 3.1.1.68 | xylono-1,4-lactonase | False | 1 | 22 | 3 | 4 | D-xylono-1,4-lactone + H2O = D-xylonate | D-xylono-1,4-lactone lactonohydrolase | None | xylono-gamma-lactonase; xylonolactonase | |
| 3.1.1.70 | cetraxate benzylesterase | True | 0 | 0 | 0 | 1 | cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol | cetraxate-benzyl-ester benzylhydrolase | None | None | |
| 3.1.1.71 | acetylalkylglycerol acetylhydrolase | False | 5 | 957 | 0 | 2 | 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate | 2-acetyl-1-alkyl-sn-glycerol acetylhydrolase | None | alkylacetylglycerol acetylhydrolase | |
| 3.1.1.72 | acetylxylan esterase | False | 28 | 997 | 12 | 48 | Deacetylation of xylans and xylo-oligosaccharides | acetylxylan esterase | None | None | |
| 3.1.1.73 | feruloyl esterase | False | 44 | 3216 | 21 | 88 | feruloyl-polysaccharide + H2O = ferulate + polysaccharide | 4-hydroxy-3-methoxycinnamoyl-sugar hydrolase | None | ferulic acid esterase; hydroxycinnamoyl esterase; hemicellulase accessory enzyme; FAE-III; cinnamoyl ester hydrolase; FAEA; cinnAE; FAE-I; FAE-II | |
| 3.1.1.74 | cutinase | False | 64 | 11016 | 45 | 57 | cutin + H2O = cutin monomers | cutin hydrolase | None | None | |
| 3.1.1.75 | poly(3-hydroxybutyrate) depolymerase | False | 3 | 379 | 8 | 51 | [(R)-3-hydroxybutanoate]n + H2O = [(R)-3-hydroxybutanoate]n-x + [(R)-3-hydroxybutanoate]x; x = 1--5 | poly[(R)-3-hydroxybutanoate] hydrolase | None | PHB depolymerase; poly(3HB) depolymerase; poly[(R)-hydroxyalkanoic acid] depolymerase; poly(HA) depolymerase; poly(HASCL) depolymerase; poly[(R)-3-hydroxybutyrate] hydrolase | |
| 3.1.1.76 | poly(3-hydroxyoctanoate) depolymerase | False | 1 | 21 | 0 | 28 | Hydrolyses the polyester poly{oxycarbonyl[(R)-2-pentylethylene]} to oligomers | poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase | None | PHO depolymerase; poly(3HO) depolymerase; poly[(R)-hydroxyalkanoic acid] depolymerase; poly(HA) depolymerase; poly(HAMCL) depolymerase; poly[(R)-3-hydroxyoctanoate] hydrolase | |
| 3.1.1.77 | acyloxyacyl hydrolase | False | 5 | 2246 | 7 | 4 | 3-(acyloxy)acyl group of bacterial toxin + H2O = 3-hydroxyacyl group of bacterial toxin + a fatty acid | None | None | None | |
| 3.1.1.78 | polyneuridine-aldehyde esterase | False | 1 | 48 | 3 | 1 | polyneuridine aldehyde + H2O = 16-epivellosimine + CO2 + methanol | polyneuridine aldehyde hydrolase (decarboxylating) | None | polyneuridine aldehyde esterase; PNAE | |
| 3.1.1.79 | hormone-sensitive lipase | False | 12 | 1149 | 1 | 18 | (1) diacylglycerol + H2O = monoacylglycerol + a carboxylate;;(2) triacylglycerol + H2O = diacylglycerol + a carboxylate;;(3) monoacylglycerol + H2O = glycerol + a carboxylate | diacylglycerol acylhydrolase | None | HSL | |
| 3.1.2.1 | acetyl-CoA hydrolase | False | 31 | 2403 | 5 | 33 | acetyl-CoA + H2O = CoA + acetate | acetyl-CoA hydrolase | None | acetyl-CoA deacylase; acetyl-CoA acylase; acetyl coenzyme A hydrolase; acetyl coenzyme A deacylase; acetyl coenzyme A acylase; acetyl-CoA thiol esterase | |
| 3.1.2.2 | palmitoyl-CoA hydrolase | False | 53 | 15545 | 7 | 40 | palmitoyl-CoA + H2O = CoA + palmitate | palmitoyl-CoA hydrolase | None | long-chain fatty-acyl-CoA hydrolase; palmitoyl coenzyme A hydrolase; palmitoyl thioesterase; palmitoyl coenzyme A hydrolase; palmitoyl-CoA deacylase; palmityl thioesterase; palmityl-CoA deacylase; fatty acyl thioesterase I; palmityl thioesterase I | |
| 3.1.2.3 | succinyl-CoA hydrolase | False | 5 | 0 | 0 | 2 | succinyl-CoA + H2O = CoA + succinate | succinyl-CoA hydrolase | None | succinyl-CoA acylase; succinyl coenzyme A hydrolase; succinyl coenzyme A deacylase | |
| 3.1.2.4 | 3-hydroxyisobutyryl-CoA hydrolase | False | 15 | 22032 | 15 | 10 | 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate | 3-hydroxy-2-methylpropanoyl-CoA hydrolase | None | 3-hydroxy-isobutyryl CoA hydrolase; HIB CoA deacylase | |
| 3.1.2.5 | hydroxymethylglutaryl-CoA hydrolase | False | 3 | 0 | 0 | 6 | (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate | (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase | None | beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase; beta-hydroxy-beta-methylglutaryl coenzyme A deacylase; hydroxymethylglutaryl coenzyme A hydrolase; hydroxymethylglutaryl coenzyme A deacylase; 3-hydroxy-3-methylglutaryl-CoA hydrolase | |
| 3.1.2.6 | hydroxyacylglutathione hydrolase | False | 287 | 22978 | 11 | 35 | S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate | S-(2-hydroxyacyl)glutathione hydrolase | None | glyoxalase II; S-2-hydroxylacylglutathione hydrolase; hydroxyacylglutathione hydrolase; acetoacetylglutathione hydrolase | |
| 3.1.2.7 | glutathione thiolesterase | True | 0 | 0 | 0 | 4 | S-acylglutathione + H2O = glutathione + a carboxylate | S-acylglutathione hydrolase | None | citryl-glutathione thioesterhydrolase | |
| 3.1.2.10 | formyl-CoA hydrolase | True | 0 | 0 | 0 | 2 | formyl-CoA + H2O = CoA + formate | formyl-CoA hydrolase | None | formyl coenzyme A hydrolase | |
| 3.1.2.11 | acetoacetyl-CoA hydrolase | False | 3 | 0 | 0 | 8 | acetoacetyl-CoA + H2O = CoA + acetoacetate | acetoacetyl-CoA hydrolase | None | acetoacetyl coenzyme A hydrolase; acetoacetyl CoA deacylase; acetoacetyl coenzyme A deacylase | |
| 3.1.2.12 | S-formylglutathione hydrolase | False | 36 | 16752 | 13 | 25 | S-formylglutathione + H2O = glutathione + formate | S-formylglutathione hydrolase | None | None | |
| 3.1.2.13 | S-succinylglutathione hydrolase | True | 0 | 0 | 0 | 1 | S-succinylglutathione + H2O = glutathione + succinate | S-succinylglutathione hydrolase | None | None | |
| 3.1.2.14 | oleoyl-[acyl-carrier-protein] hydrolase | False | 27 | 4330 | 5 | 45 | an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate | oleoyl-[acyl-carrier protein] hydrolase | None | acyl-[acyl-carrier-protein] hydrolase; acyl-ACP-hydrolase; acyl-acyl carrier protein hydrolase; oleoyl-ACP thioesterase; oleoyl-acyl carrier protein thioesterase; oleoyl-[acyl-carrier-protein] hydrolase | |
| 3.1.2.16 | citrate-lyase deacetylase | True | 0 | 0 | 0 | 2 | acetyl-[citrate (pro-3S)-lyase] + H2O = holo-[citrate (pro-3S)-lyase] + acetate | acetyl-[citrate-(pro-3S)-lyase] hydrolase | None | [citrate-(pro-3S)-lyase] thiolesterase; acetyl-S-(acyl-carrier protein) enzyme thioester hydrolase; citrate lyase deacetylase; [citrate-(pro-3S)-lyase](acetyl-form) hydrolase | |
| 3.1.2.17 | (S)-methylmalonyl-CoA hydrolase | True | 0 | 0 | 0 | 1 | (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA | (S)-methylmalonyl-CoA hydrolase | None | D-methylmalonyl-coenzyme A hydrolase | |
| 3.1.2.18 | ADP-dependent short-chain-acyl-CoA hydrolase | False | 0 | 13 | 0 | 3 | acyl-CoA + H2O = CoA + a carboxylate | ADP-dependent-short-chain-acyl-CoA hydrolase | None | short-chain acyl coenzyme A hydrolase; propionyl coenzyme A hydrolase; propionyl-CoA hydrolase; propionyl-CoA thioesterase; short-chain acyl-CoA hydrolase; short-chain acyl-CoA thioesterase | |
| 3.1.2.19 | ADP-dependent medium-chain-acyl-CoA hydrolase | False | 0 | 1 | 0 | 2 | acyl-CoA + H2O = CoA + a carboxylate | ADP-dependent-medium-chain-acyl-CoA hydrolase | None | medium-chain acyl coenzyme A hydrolase; medium-chain acyl-CoA hydrolase; medium-chain acyl-thioester hydrolase; medium-chain hydrolase; myristoyl-CoA thioesterase | |
| 3.1.2.20 | acyl-CoA hydrolase | False | 11 | 10689 | 5 | 44 | acyl-CoA + H2O = CoA + a carboxylate | acyl-CoA hydrolase | None | acyl coenzyme A thioesterase; acyl-CoA thioesterase; acyl coenzyme A hydrolase; thioesterase B; thioesterase II; acyl-CoA thioesterase | |
| 3.1.2.21 | dodecanoyl-[acyl-carrier-protein] hydrolase | False | 2 | 80 | 1 | 2 | a dodecanoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + dodecanoate | dodecanoyl-[acyl-carrier protein] hydrolase | None | lauryl-acyl-carrier-protein hydrolase; dodecanoyl-acyl-carrier-protein hydrolase; dodecyl-acyl-carrier protein hydrolase; dodecanoyl-[acyl-carrier protein] hydrolase; dodecanoyl-[acyl-carrier-protein] hydrolase | |
| 3.1.2.22 | palmitoyl[protein] hydrolase | False | 82 | 19768 | 5 | 9 | palmitoyl[protein] + H2O = palmitate + protein | palmitoyl[protein] hydrolase | None | palmitoyl-protein thioesterase; palmitoyl-(protein) hydrolase | |
| 3.1.2.23 | 4-hydroxybenzoyl-CoA thioesterase | False | 3 | 395 | 18 | 3 | 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA | 4-hydroxybenzoyl-CoA hydrolase | None | None | |
| 3.1.2.25 | phenylacetyl-CoA hydrolase | False | 0 | 4 | 0 | 3 | phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA | phenylglyoxylyl-CoA hydrolase | None | None | |
| 3.1.2.27 | choloyl-CoA hydrolase | False | 6 | 90 | 0 | 3 | choloyl-CoA + H2O = cholate + CoA | choloyl-CoA hydrolase | None | PTE-2 (ambiguous); choloyl-coenzyme A thioesterase; chenodeoxycholoyl-coenzyme A thioesterase; peroxisomal acyl-CoA thioesterase 2 | |
| 3.1.3.1 | alkaline phosphatase | False | 37 | 16858 | 106 | 122 | a phosphate monoester + H2O = an alcohol + phosphate | phosphate-monoester phosphohydrolase (alkaline optimum) | None | alkaline phosphomonoesterase; phosphomonoesterase; glycerophosphatase; alkaline phosphohydrolase; alkaline phenyl phosphatase; orthophosphoric-monoester phosphohydrolase (alkaline optimum) | |
| 3.1.3.2 | acid phosphatase | False | 123 | 25775 | 100 | 152 | a phosphate monoester + H2O = an alcohol + phosphate | phosphate-monoester phosphohydrolase (acid optimum) | None | acid phosphomonoesterase; phosphomonoesterase; glycerophosphatase; acid monophosphatase; acid phosphohydrolase; acid phosphomonoester hydrolase; uteroferrin; acid nucleoside diphosphate phosphatase; orthophosphoric-monoester phosphohydrolase (acid optimum) | |
| 3.1.3.3 | phosphoserine phosphatase | False | 40 | 39297 | 42 | 21 | O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate | O-phosphoserine phosphohydrolase | None | None | |
| 3.1.3.4 | phosphatidate phosphatase | False | 37 | 7825 | 0 | 29 | a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate | diacylglycerol-3-phosphate phosphohydrolase | None | phosphatic acid phosphatase; acid phosphatidyl phosphatase; phosphatic acid phosphohydrolase; PAP; Lipin | |
| 3.1.3.5 | 5'-nucleotidase | False | 567 | 46196 | 146 | 98 | a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate | 5'-ribonucleotide phosphohydrolase | None | uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase | |
| 3.1.3.6 | 3'-nucleotidase | False | 65 | 2699 | 0 | 27 | a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate | 3'-ribonucleotide phosphohydrolase | None | 3'-mononucleotidase; 3'-phosphatase; 3'-ribonucleotidase | |
| 3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase | False | 47 | 17788 | 19 | 20 | adenosine 3',5'-bisphosphate + H2O = AMP + phosphate | adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase | None | phosphoadenylate 3'-nucleotidase; 3'-phosphoadenylylsulfate 3'-phosphatase; 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase | |
| 3.1.3.8 | 3-phytase | False | 19 | 4502 | 23 | 160 | myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate | myo-inositol-hexakisphosphate 3-phosphohydrolase | None | 1-phytase; phytase; phytate 1-phosphatase; phytate 6-phosphatase | |
| 3.1.3.9 | glucose-6-phosphatase | False | 15 | 3036 | 0 | 74 | D-glucose 6-phosphate + H2O = D-glucose + phosphate | D-glucose-6-phosphate phosphohydrolase | None | glucose 6-phosphate phosphatase | |
| 3.1.3.10 | glucose-1-phosphatase | False | 5 | 1733 | 4 | 9 | alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate | alpha-D-glucose-1-phosphate phosphohydrolase | None | None | |
| 3.1.3.11 | fructose-bisphosphatase | False | 540 | 33850 | 170 | 94 | D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | D-fructose-1,6-bisphosphate 1-phosphohydrolase | None | hexose diphosphatase; FBPase; fructose 1,6-diphosphatase; fructose 1,6-diphosphate phosphatase; D-fructose 1,6-diphosphatase; fructose 1,6-bisphosphatase; fructose diphosphatase; fructose diphosphate phosphatase; fructose bisphosphate phosphatase; fructose 1,6-bisphosphate 1-phosphatase; fructose 1,6-bisphosphate phosphatase; hexose bisphosphatase; D-fructose-1,6-bisphosphate phosphatase | |
| 3.1.3.12 | trehalose-phosphatase | False | 45 | 16663 | 9 | 40 | alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate | alpha,alpha-trehalose-6-phosphate phosphohydrolase | None | trehalose 6-phosphatase; trehalose 6-phosphate phosphatase; trehalose-6-phosphate phosphohydrolase | |
| 3.1.3.14 | methylphosphothioglycerate phosphatase | True | 0 | 0 | 0 | 1 | S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate | S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase | None | methylthiophosphoglycerate phosphatase | |
| 3.1.3.15 | histidinol-phosphatase | False | 79 | 29920 | 15 | 15 | L-histidinol phosphate + H2O = L-histidinol + phosphate | L-histidinol-phosphate phosphohydrolase | None | histidinol phosphate phosphatase; L-histidinol phosphate phosphatase; histidinolphosphate phosphatase; HPpase; histidinolphosphatase | |
| 3.1.3.16 | protein-serine/threonine phosphatase | False | 760 | 177375 | 325 | 78 | [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate | protein-serine/threonine-phosphate phosphohydrolase | None | phosphoprotein phosphatase (ambiguous); protein phosphatase-1; protein phosphatase-2A; protein phosphatase-2B; protein phosphatase-2C; protein D phosphatase; phosphospectrin phosphatase; casein phosphatase; Aspergillus awamori acid protein phosphatase; calcineurin; phosphatase 2A; phosphatase 2B; phosphatase II; phosphatase IB; phosphatase C-II; polycation modulated (PCM-) phosphatase; phosphopyruvate dehydrogenase phosphatase; phosphatase SP; branched-chain alpha-keto acid dehydrogenase phosphatase; BCKDH phosphatase; 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase; HMG-CoA reductase phosphatase; phosphatase H-II; phosphatase III; phosphatase I; protein phosphatase; phosphatase IV; phosphoprotein phosphohydrolase | |
| 3.1.3.17 | [phosphorylase] phosphatase | False | 0 | 2 | 0 | 7 | [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate | [phosphorylase a] phosphohydrolase | None | PR-enzyme; phosphorylase a phosphatase; glycogen phosphorylase phosphatase; protein phosphatase C; type 1 protein phosphatase | |
| 3.1.3.18 | phosphoglycolate phosphatase | False | 98 | 19094 | 7 | 38 | 2-phosphoglycolate + H2O = glycolate + phosphate | 2-phosphoglycolate phosphohydrolase | None | phosphoglycolate hydrolase; 2-phosphoglycolate phosphatase; P-glycolate phosphatase; phosphoglycollate phosphatase | |
| 3.1.3.19 | glycerol-2-phosphatase | False | 0 | 1 | 0 | 25 | glycerol 2-phosphate + H2O = glycerol + phosphate | glycerol-2-phosphate phosphohydrolase | None | beta-glycerophosphatase; beta-glycerophosphate phosphatase; 2-glycerophosphatase | |
| 3.1.3.20 | phosphoglycerate phosphatase | True | 0 | 0 | 0 | 5 | D-glycerate 2-phosphate + H2O = D-glycerate + phosphate | D-glycerate-2-phosphate phosphohydrolase | None | D-2-phosphoglycerate phosphatase; glycerophosphate phosphatase | |
| 3.1.3.21 | glycerol-1-phosphatase | False | 9 | 1131 | 2 | 15 | glycerol 1-phosphate + H2O = glycerol + phosphate | glycerol-1-phosphate phosphohydrolase | None | alpha-glycerophosphatase; alpha-glycerol phosphatase; glycerol 3-phosphatase; glycerol-3-phosphate phosphatase; glycerol 3-phosphate phosphohydrolase | |
| 3.1.3.22 | mannitol-1-phosphatase | False | 4 | 288 | 0 | 33 | D-mannitol 1-phosphate + H2O = D-mannitol + phosphate | D-mannitol-1-phosphate phosphohydrolase | None | mannitol-1-phosphate phosphatase | |
| 3.1.3.23 | sugar-phosphatase | False | 11 | 3838 | 1 | 14 | sugar phosphate + H2O = sugar + phosphate | sugar-phosphate phosphohydrolase | None | None | |
| 3.1.3.24 | sucrose-phosphate phosphatase | False | 11 | 1447 | 9 | 43 | sucrose 6F-phosphate + H2O = sucrose + phosphate | sucrose-6F-phosphate phosphohydrolase | None | sucrose 6-phosphate hydrolase; sucrose-phosphate hydrolase; sucrose-phosphate phosphohydrolase; sucrose-6-phosphatase; sucrose phosphatase; sucrose-6-phosphate phosphatase; SPP | |
| 3.1.3.25 | inositol-phosphate phosphatase | False | 68 | 41933 | 44 | 27 | myo-inositol phosphate + H2O = myo-inositol + phosphate | myo-inositol-phosphate phosphohydrolase | None | myo-inositol-1(or 4)-monophosphatase; inositol 1-phosphatase; L-myo-inositol-1-phosphate phosphatase; myo-inositol 1-phosphatase; inositol phosphatase; inositol monophosphate phosphatase; inositol-1(or 4)-monophosphatase; myo-inositol-1(or 4)-phosphate phosphohydrolase; myo-inositol monophosphatase; myo-inositol-1-phosphatase | |
| 3.1.3.26 | 4-phytase | False | 0 | 421 | 13 | 127 | myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate | myo-inositol-hexakisphosphate 4-phosphohydrolase | None | 6-phytase (name based on 1L-numbering system and not 1D-numbering); phytase; phytate 6-phosphatase; myo-inositol-hexakisphosphate 6-phosphohydrolase (name based on 1L-numbering system and not 1D-numbering) | |
| 3.1.3.27 | phosphatidylglycerophosphatase | False | 19 | 10801 | 6 | 16 | phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate | phosphatidylglycerophosphate phosphohydrolase | None | phosphatidylglycerol phosphate phosphatase; phosphatidylglycerol phosphatase; PGP phosphatase | |
| 3.1.3.28 | ADP-phosphoglycerate phosphatase | True | 0 | 0 | 0 | 1 | 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate | 3-(ADP)-2-phosphoglycerate phosphohydrolase | None | adenosine diphosphate phosphoglycerate phosphatase | |
| 3.1.3.29 | N-acylneuraminate-9-phosphatase | False | 3 | 36 | 3 | 2 | N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate | N-acylneuraminate-9-phosphate phosphohydrolase | None | acylneuraminate 9-phosphatase; N-acylneuraminic acid 9-phosphate phosphatase; N-acylneuraminic (sialic) acid 9-phosphatase | |
| 3.1.3.32 | polynucleotide 3'-phosphatase | False | 7 | 54 | 10 | 15 | a 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate | polynucleotide 3'-phosphohydrolase | None | 2'(3')-polynucleotidase; DNA 3'-phosphatase; deoxyribonucleate 3'-phosphatase; 5'-polynucleotidekinase 3'-phosphatase | |
| 3.1.3.33 | polynucleotide 5'-phosphatase | False | 0 | 7 | 13 | 1 | a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate | polynucleotide 5'-phosphohydrolase | None | 5'-polynucleotidase | |
| 3.1.3.34 | deoxynucleotide 3'-phosphatase | False | 1 | 0 | 0 | 4 | a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate | 2'-deoxyribonucleotide 3'-phosphohydrolase | None | 3'-deoxynucleotidase; 3'-deoxyribonucleotidase | |
| 3.1.3.35 | thymidylate 5'-phosphatase | False | 4 | 1 | 0 | 5 | thymidylate + H2O = thymidine + phosphate | thymidylate 5'-phosphohydrolase | None | thymidylate 5'-nucleotidase; deoxythymidylate 5'-nucleotidase; thymidylate nucleotidase; deoxythymidylic 5'-nucleotidase; deoxythymidylate phosphohydrolase; dTMPase | |
| 3.1.3.36 | phosphoinositide 5-phosphatase | False | 42 | 9070 | 21 | 26 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | None | type II inositol polyphosphate 5-phosphatase; triphosphoinositide phosphatase; IP3 phosphatase; PtdIns(4,5)P2 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase | |
| 3.1.3.37 | sedoheptulose-bisphosphatase | False | 36 | 774 | 4 | 22 | sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate | sedoheptulose-1,7-bisphosphate 1-phosphohydrolase | None | SBPase; sedoheptulose 1,7-diphospate phosphatase; sedoheptulose 1,7-diphosphatase; sedoheptulose diphosphatase; sedoheptulose bisphosphatase; sedoheptulose 1,7-bisphosphatase | |
| 3.1.3.38 | 3-phosphoglycerate phosphatase | True | 0 | 0 | 0 | 39 | D-glycerate 3-phosphate + H2O = D-glycerate + phosphate | D-glycerate-3-phosphate phosphohydrolase | None | D-3-Phosphoglycerate phosphatase; 3-PGA phosphatase | |
| 3.1.3.39 | streptomycin-6-phosphatase | False | 1 | 11 | 0 | 7 | streptomycin 6-phosphate + H2O = streptomycin + phosphate | streptomycin-6-phosphate phosphohydrolase | None | streptomycin 6-phosphate phosphatase; streptomycin 6-phosphate phosphohydrolase; streptomycin-6-P phosphohydrolase | |
| 3.1.3.40 | guanidinodeoxy-scyllo-inositol-4-phosphatase | True | 0 | 0 | 0 | 4 | 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate | 1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase | None | 1-guanidino-scyllo-inositol 4-phosphatase; 1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase | |
| 3.1.3.41 | 4-nitrophenylphosphatase | False | 2 | 1910 | 1 | 10 | 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate | 4-nitrophenylphosphate phosphohydrolase | None | nitrophenyl phosphatase; p-nitrophenylphosphatase; para-nitrophenyl phosphatase; K-pNPPase; NPPase; PNPPase; Ecto-p-nitrophenyl phosphatase; p-nitrophenylphosphate phosphohydrolase | |
| 3.1.3.42 | [glycogen-synthase-D] phosphatase | True | 0 | 0 | 0 | 4 | [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate | [UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D] phosphohydrolase | None | uridine diphosphoglucose-glycogen glucosyltransferase phosphatase; UDP-glycogen glucosyltransferase phosphatase; UDPglucose-glycogen glucosyltransferase phosphatase; glycogen glucosyltransferase phosphatase; glycogen synthetase phosphatase; glycogen synthase phosphatase; glycogen synthase D phosphatase; Mg2+ dependent glycogen synthase phosphatase; phosphatase type 2_degree_C | |
| 3.1.3.43 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase | False | 10 | 1201 | 3 | 11 | [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate | [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase | None | pyruvate dehydrogenase phosphatase; phosphopyruvate dehydrogenase phosphatase; [pyruvate dehydrogenase (lipoamide)]-phosphatase; [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase | |
| 3.1.3.44 | [acetyl-CoA carboxylase]-phosphatase | False | 0 | 1 | 0 | 2 | [acetyl-CoA carboxylase] phosphate + H2O = [acetyl-CoA carboxylase] + phosphate | [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]-phosphate phosphohydrolase | None | None | |
| 3.1.3.45 | 3-deoxy-manno-octulosonate-8-phosphatase | False | 9 | 18645 | 14 | 5 | 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate | 3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase | None | None | |
| 3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase | False | 32 | 2974 | 5 | 26 | beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase | None | fructose-2,6-bisphosphatase; D-fructose-2,6-bisphosphate 2-phosphohydrolase | |
| 3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase | True | 0 | 0 | 0 | 1 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O = [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase | None | reductase phosphatase | |
| 3.1.3.48 | protein-tyrosine-phosphatase | False | 522 | 150531 | 987 | 55 | [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate | protein-tyrosine-phosphate phosphohydrolase | None | phosphotyrosine phosphatase; phosphoprotein phosphatase (phosphotyrosine); phosphotyrosine histone phosphatase; protein phosphotyrosine phosphatase; tyrosylprotein phosphatase; phosphotyrosine protein phosphatase; phosphotyrosylprotein phosphatase; tyrosine O-phosphate phosphatase; PPT-phosphatase; PTPase; [phosphotyrosine]protein phosphatase; PTP-phosphatase | |
| 3.1.3.49 | [pyruvate kinase]-phosphatase | False | 0 | 2 | 0 | 2 | [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate | [ATP:pyruvate 2-O-phosphotransferase]-phosphate phosphohydrolase | None | pyruvate kinase phosphatase | |
| 3.1.3.50 | sorbitol-6-phosphatase | False | 5 | 232 | 0 | 3 | sorbitol 6-phosphate + H2O = sorbitol + phosphate | sorbitol-6-phosphate phosphohydrolase | None | sorbitol-6-phosphate phosphatase | |
| 3.1.3.51 | dolichyl-phosphatase | False | 0 | 2 | 0 | 6 | dolichyl phosphate + H2O = dolichol + phosphate | dolichyl-phosphate phosphohydrolase | None | dolichol phosphate phosphatase; dolichol phosphatase; dolichol monophosphatase; dolichyl monophosphate phosphatase; dolichyl phosphate phosphatase; polyisoprenyl phosphate phosphatase; polyprenylphosphate phosphatase; Dol-P phosphatase | |
| 3.1.3.52 | [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase | False | 5 | 229 | 0 | 4 | [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O = [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate | [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase | None | branched-chain oxo-acid dehydrogenase phosphatase; branched-chain 2-keto acid dehydrogenase phosphatase; branched-chain alpha-keto acid dehydrogenase phosphatase; BCKDH (ambiguous); [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase; [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase | |
| 3.1.3.53 | [myosin-light-chain] phosphatase | False | 9 | 20 | 0 | 14 | [myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate | [myosin-light-chain]-phosphate phosphohydrolase | None | myosin light chain kinase phosphatase; myosin phosphatase; myosin phosphatase; protein phosphatase 2A; myosin-light-chain-phosphatase | |
| 3.1.3.54 | fructose-2,6-bisphosphate 6-phosphatase | False | 1 | 0 | 0 | 1 | beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate | beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase | None | fructose 2,6-bisphosphate-6-phosphohydrolase; fructose-2,6-bisphosphate 6-phosphohydrolase; D-fructose-2,6-bisphosphate 6-phosphohydrolase | |
| 3.1.3.55 | caldesmon-phosphatase | True | 0 | 0 | 0 | 3 | caldesmon phosphate + H2O = caldesmon + phosphate | caldesmon-phosphate phosphohydrolase | None | SMP-I; smooth muscle caldesmon phosphatase | |
| 3.1.3.56 | inositol-polyphosphate 5-phosphatase | False | 21 | 2640 | 0 | 16 | (1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate;;(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate | 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase | None | type I inositol-polyphosphate phosphatase; inositol trisphosphate phosphomonoesterase; InsP3/Ins(1,3,4,5)P4 5-phosphatase; inosine triphosphatase; D-myo-inositol 1,4,5-triphosphate 5-phosphatase; D-myo-inositol 1,4,5-trisphosphate 5-phosphatase; L-myo-inositol 1,4,5-trisphosphate-monoesterase; inositol phosphate 5-phosphomonoesterase; inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase; Ins(1,4,5)P3 5-phosphatase; D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase; inositol 1,4,5-trisphosphate phosphatase; inositol polyphosphate-5-phosphatase; myo-inositol-1,4,5-trisphosphate 5-phosphatase; inositol-1,4,5-trisphosphate 5-phosphatase | |
| 3.1.3.57 | inositol-1,4-bisphosphate 1-phosphatase | False | 16 | 2364 | 8 | 7 | 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate | 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase | None | inositol-polyphosphate 1-phosphatase | |
| 3.1.3.58 | sugar-terminal-phosphatase | False | 0 | 23 | 0 | 2 | D-glucose 6-phosphate + H2O = D-glucose + phosphate | sugar-omega-phosphate phosphohydrolase | None | xylitol-5-phosphatase | |
| 3.1.3.59 | alkylacetylglycerophosphatase | True | 0 | 0 | 0 | 2 | 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate | 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase | None | 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase; alkylacetylglycerophosphate phosphatase | |
| 3.1.3.60 | phosphoenolpyruvate phosphatase | False | 2 | 0 | 0 | 9 | phosphoenolpyruvate + H2O = pyruvate + phosphate | phosphoenolpyruvate phosphohydrolase | None | PEP phosphatase | |
| 3.1.3.62 | multiple inositol-polyphosphate phosphatase | False | 7 | 1512 | 3 | 11 | (1) myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate;;(2) 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate;;(3) 1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate;;(4) 1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate;;(5) 1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate | myo-inositol-hexakisphosphate phosphohydrolase | None | MIPP; phytase (ambiguous); 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase (incorrect) | |
| 3.1.3.63 | 2-carboxy-D-arabinitol-1-phosphatase | False | 2 | 11 | 0 | 3 | 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate | 2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase | None | 2-carboxyarabinitol 1-phosphatase; 2-carboxy-D-arabinitol 1-phosphate phosphohydrolase | |
| 3.1.3.64 | phosphatidylinositol-3-phosphatase | False | 48 | 14501 | 5 | 8 | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | None | inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase | |
| 3.1.3.66 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase | False | 8 | 3507 | 0 | 5 | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase | None | inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II | |
| 3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | False | 15 | 1217 | 3 | 9 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase | None | PTEN (gene name); MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase | |
| 3.1.3.68 | 2-deoxyglucose-6-phosphatase | False | 4 | 425 | 0 | 1 | 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate | 2-deoxy-D-glucose-6-phosphate phosphohydrolase | None | 2-deoxyglucose-6-phosphate phosphatase | |
| 3.1.3.69 | glucosylglycerol 3-phosphatase | False | 1 | 132 | 0 | 2 | 2-O-(alpha-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate | 2-O-(alpha-D-glucopyranosyl)-sn-glycerol-3-phosphate phosphohydrolase | None | salt tolerance protein A; StpA; 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase (incorrect) | |
| 3.1.3.70 | mannosyl-3-phosphoglycerate phosphatase | False | 36 | 1278 | 12 | 3 | 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate | 2-O-(alpha-D-mannosyl)-3-phosphoglycerate phosphohydrolase | None | None | |
| 3.1.3.71 | 2-phosphosulfolactate phosphatase | False | 60 | 8382 | 3 | 3 | (2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate | (R)-2-phospho-3-sulfolactate phosphohydrolase | None | (2R)-phosphosulfolactate phosphohydrolase; ComB phosphatase | |
| 3.1.3.72 | 5-phytase | False | 0 | 0 | 6 | 9 | myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate | myo-inositol-hexakisphosphate 5-phosphohydrolase | None | None | |
| 3.1.3.73 | adenosylcobalamin/alpha-ribazole phosphatase | False | 4 | 4634 | 18 | 3 | (1) adenosylcobalamin 5'-phosphate + H2O = adenosylcobalamin + phosphate;;(2) alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate | adenosylcobalamin/alpha-ribazole-5'-phosphate phosphohydrolase | None | CobC; adenosylcobalamin phosphatase; alpha-ribazole phosphatase | |
| 3.1.3.74 | pyridoxal phosphatase | False | 11 | 1277 | 10 | 13 | pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate | pyridoxal-5'-phosphate phosphohydrolase | None | vitamine B6 (pyridoxine) phosphatase; PLP phosphatase; vitamin B6-phosphate phosphatase; PNP phosphatase | |
| 3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase | False | 5 | 11 | 2 | 5 | (1) O-phosphoethanolamine + H2O = ethanolamine + phosphate;;(2) phosphocholine + H2O = choline + phosphate | phosphoethanolamine phosphohydrolase | None | PHOSPHO1; 3X11A | |
| 3.1.4.1 | phosphodiesterase I | False | 21 | 7280 | 22 | 44 | Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides | oligonucleotide 5'-nucleotidohydrolase | None | 5'-exonuclease; 5'-phosphodiesterase; 5'-nucleotide phosphodiesterase; oligonucleate 5'-nucleotidohydrolase; 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I; 5'-NPDase; 5'-PDase; 5'-PDE; 5'NPDE; alkaline phosphodiesterase; nucleotide pyrophosphatase/phosphodiesterase I; orthophosphoric diester phosphohydrolase; PDE I; phosphodiesterase (ambiguous); exonuclease I | |
| 3.1.4.2 | glycerophosphocholine phosphodiesterase | False | 10 | 22 | 1 | 26 | sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate | sn-glycero-3-phosphocholine glycerophosphohydrolase | None | glycerophosphinicocholine diesterase; glycerylphosphorylcholinediesterase; sn-glycero-3-phosphorylcholine diesterase; glycerolphosphorylcholine phosphodiesterase; glycerophosphohydrolase | |
| 3.1.4.3 | phospholipase C | False | 32 | 10344 | 20 | 55 | a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine | phosphatidylcholine cholinephosphohydrolase | None | lipophosphodiesterase I; lecithinase C; Clostridium welchii alpha-toxin; Clostridium oedematiens beta- and gamma-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; alpha-toxin | |
| 3.1.4.4 | phospholipase D | False | 58 | 30449 | 32 | 83 | a phosphatidylcholine + H2O = choline + a phosphatidate | phosphatidylcholine phosphatidohydrolase | None | lipophosphodiesterase II; lecithinase D; choline phosphatase | |
| 3.1.4.11 | phosphoinositide phospholipase C | False | 70 | 34576 | 58 | 65 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase | None | triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase | |
| 3.1.4.12 | sphingomyelin phosphodiesterase | False | 36 | 5723 | 19 | 29 | a sphingomyelin + H2O = a ceramide + phosphocholine | sphingomyelin cholinephosphohydrolase | None | neutral sphingomyelinase | |
| 3.1.4.13 | serine-ethanolaminephosphate phosphodiesterase | True | 0 | 0 | 0 | 1 | serine phosphoethanolamine + H2O = serine + ethanolamine phosphate | serine-phosphoethanolamine ethanolaminephosphohydrolase | None | serine ethanolamine phosphodiester phosphodiesterase; SEP diesterase | |
| 3.1.4.14 | [acyl-carrier-protein] phosphodiesterase | False | 51 | 1193 | 2 | 4 | holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier protein] | holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase | None | ACP hydrolyase; ACP phosphodiesterase; AcpH; [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase; holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase | |
| 3.1.4.16 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase | False | 9 | 2307 | 1 | 19 | nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate | nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase | None | ribonucleoside 2',3'-cyclic phosphate diesterase; 2',3 '-cyclic AMP phosphodiesterase; 2',3'-cyclic nucleotidase; cyclic 2',3'-nucleotide 2'-phosphodiesterase; cyclic 2',3'-nucleotide phosphodiesterase; 2',3'-cyclic nucleoside monophosphate phosphodiesterase; 2',3'-cyclic AMP 2'-phosphohydrolase; cyclic phosphodiesterase:3'-nucleotidase; 2',3'-cyclic nucleotide phosphohydrolase; 2':3'-cyclic phosphodiesterase; 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase | |
| 3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase | False | 39 | 1550 | 523 | 26 | nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate | 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase | None | cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP); cyclic 3',5-nucleotide monophosphate phosphodiesterase; nucleoside 3',5'-cyclic phosphate diesterase; nucleoside-3',5-monophosphate phosphodiesterase | |
| 3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase | False | 59 | 2725 | 70 | 26 | guanosine 3',5'-cyclic phosphate + H2O = GMP | 3',5'-cyclic-GMP 5'-nucleotidohydrolase | None | guanosine cyclic 3',5'-phosphate phosphodiesterase; cyclic GMP phosphodiesterase; cyclic 3',5'-GMP phosphodiesterase; cyclic guanosine 3',5'-monophosphate phosphodiesterase; cyclic guanosine 3',5'-phosphate phosphodiesterase; cGMP phosphodiesterase; cGMP-PDE | |
| 3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | False | 15 | 1145 | 36 | 29 | nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate | nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase | None | cyclic-CMP phosphodiesterase; 2',3'-cyclic AMP phosphodiesterase; cyclic 2',3'-nucleotide 3'-phosphodiesterase; cyclic 2',3'-nucleotide phosphodiesterase; 2',3'-cyclic nucleoside monophosphate phosphodiesterase; 2',3'-cyclic nucleotide 3'-phosphohydrolase; CNPase; 2',3'-cyclic nucleotide phosphohydrolase; 2':3'-cyclic nucleotide 3'-phosphodiesterase; 2':3'-CNMP-3'-ase | |
| 3.1.4.38 | glycerophosphocholine cholinephosphodiesterase | False | 8 | 1326 | 1 | 5 | sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine | sn-glycero-3-phosphocholine cholinephosphohydrolase | None | L-3-glycerylphosphinicocholine cholinephosphohydrolase | |
| 3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase | False | 4 | 14 | 60 | 13 | 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine | 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase | None | lysophospholipase D | |
| 3.1.4.40 | CMP-N-acylneuraminate phosphodiesterase | True | 0 | 0 | 0 | 5 | CMP-N-acylneuraminate + H2O = CMP + N-acylneuraminate | CMP-N-acylneuraminate N-acylneuraminohydrolase | None | CMP-sialate hydrolase; CMP-sialic acid hydrolase; CMP-N-acylneuraminic acid hydrolase; cytidine monophosphosialic hydrolase; cytidine monophosphosialate hydrolase; cytidine monophosphate-N-acetylneuraminic acid hydrolase; CMP-N-acetylneuraminate hydrolase | |
| 3.1.4.41 | sphingomyelin phosphodiesterase D | False | 10 | 15 | 4 | 42 | sphingomyelin + H2O = ceramide phosphate + choline | sphingomyelin ceramide-phosphohydrolase | None | sphingomyelinase D | |
| 3.1.4.42 | glycerol-1,2-cyclic-phosphate 2-phosphodiesterase | True | 0 | 0 | 0 | 5 | glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate | rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase | None | rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase | |
| 3.1.4.43 | glycerophosphoinositol inositolphosphodiesterase | False | 2 | 0 | 0 | 1 | 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate | 1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase | None | 1,2-cyclic-inositol-phosphate phosphodiesterase; D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase; D-inositol 1,2-cyclic phosphate 2-phosphohydrolase; D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase; 1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase; inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase | |
| 3.1.4.44 | glycerophosphoinositol glycerophosphodiesterase | False | 4 | 15 | 0 | 4 | 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate | 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase | None | sn-glycero(3)phosphoinositol glycerophosphohydrolase; sn-glycero-3-phospho-1-inositol glycerophosphohydrolase | |
| 3.1.4.45 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | False | 3 | 46 | 0 | 7 | glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose | glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase | None | alpha-N-acetylglucosaminyl phosphodiesterase; lysosomal alpha-N-acetylglucosaminidase; phosphodiester glycosidase; alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase; 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase | |
| 3.1.4.46 | glycerophosphodiester phosphodiesterase | False | 28 | 23937 | 20 | 35 | a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate | glycerophosphodiester glycerophosphohydrolase | None | gene hpd protein; glycerophosphoryl diester phosphodiesterase; IgD-binding protein D | |
| 3.1.4.48 | dolichylphosphate-glucose phosphodiesterase | True | 0 | 0 | 0 | 1 | dolichyl beta-D-glucosyl phosphate + H2O = dolichyl phosphate + D-glucose | dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase | None | dolichol phosphoglucose phosphodiesterase; Dol-P-Glc phosphodiesterase | |
| 3.1.4.49 | dolichylphosphate-mannose phosphodiesterase | True | 0 | 0 | 0 | 2 | dolichyl beta-D-mannosyl phosphate + H2O = dolichyl phosphate + D-mannose | dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase | None | mannosylphosphodolichol phosphodiesterase | |
| 3.1.4.50 | glycosylphosphatidylinositol phospholipase D | False | 5 | 751 | 0 | 8 | 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate | glycoprotein-phosphatidylinositol phosphatidohydrolase | None | GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D | |
| 3.1.4.51 | glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase | True | 0 | 0 | 0 | 1 | 6-(D-glucose-1-phospho)-D-mannosylglycoprotein + H2O = alpha-D-glucose 1-phosphate + D-mannosylglycoprotein | 6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase | None | alpha-glucose-1-phosphate phosphodiesterase | |
| 3.1.5.1 | dGTPase | False | 54 | 3310 | 19 | 11 | dGTP + H2O = deoxyguanosine + triphosphate | dGTP triphosphohydrolase | None | deoxy-GTPase; deoxyguanosine 5-triphosphate triphosphohydrolase; deoxyguanosine triphosphatase; deoxyguanosine triphosphate triphosphohydrolase | |
| 3.1.6.1 | arylsulfatase (type I) | False | 30 | 12265 | 9 | 44 | an aryl sulfate + H2O = a phenol + sulfate | aryl-sulfate sulfohydrolase | None | sulfatase; nitrocatechol sulfatase; phenolsulfatase; phenylsulfatase; p-nitrophenyl sulfatase; arylsulfohydrolase; 4-methylumbelliferyl sulfatase; estrogen sulfatase; type I sulfatase; arylsulfatase | |
| 3.1.6.2 | steryl-sulfatase | False | 3 | 37 | 2 | 16 | 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate | steryl-sulfate sulfohydrolase | None | arylsulfatase; steroid sulfatase; sterol sulfatase; dehydroepiandrosterone sulfate sulfatase; arylsulfatase C; steroid 3-sulfatase; steroid sulfate sulfohydrolase; dehydroepiandrosterone sulfatase; pregnenolone sulfatase; phenolic steroid sulfatase; 3-beta-hydroxysteroid sulfate sulfatase | |
| 3.1.6.3 | glycosulfatase | True | 0 | 0 | 0 | 12 | D-glucose 6-sulfate + H2O = D-glucose + sulfate | sugar-sulfate sulfohydrolase | None | glucosulfatase | |
| 3.1.6.4 | N-acetylgalactosamine-6-sulfatase | False | 5 | 864 | 2 | 12 | Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate | N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase | None | chondroitin sulfatase; chondroitinase; galactose-6-sulfate sulfatase; acetylgalactosamine 6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine 6-sulfatase | |
| 3.1.6.6 | choline-sulfatase | False | 1 | 4335 | 5 | 8 | choline sulfate + H2O = choline + sulfate | choline-sulfate sulfohydrolase | None | None | |
| 3.1.6.7 | cellulose-polysulfatase | True | 0 | 0 | 0 | 1 | Hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin | cellulose-sulfate sulfohydrolase | None | None | |
| 3.1.6.8 | cerebroside-sulfatase | False | 3 | 111 | 7 | 20 | a cerebroside 3-sulfate + H2O = a cerebroside + sulfate | cerebroside-3-sulfate 3-sulfohydrolase | None | arylsulfatase A; cerebroside sulfate sulfatase | |
| 3.1.6.9 | chondro-4-sulfatase | True | 0 | 0 | 0 | 2 | 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate | 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase | None | chondroitin-4-sulfatase; 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase | |
| 3.1.6.10 | chondro-6-sulfatase | True | 0 | 0 | 0 | 1 | 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate | 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase | None | 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase | |
| 3.1.6.11 | disulfoglucosamine-6-sulfatase | True | 0 | 0 | 0 | 3 | 2-N,6-O-disulfo-D-glucosamine + H2O = 2-N-sulfo-D-glucosamine + sulfate | 2-N,6-O-disulfo-D-glucosamine 6-sulfohydrolase | None | N-sulfoglucosamine-6-sulfatase; 6,N-disulfoglucosamine 6-O-sulfohydrolase; N,6-O-disulfo-D-glucosamine 6-sulfohydrolase | |
| 3.1.6.12 | N-acetylgalactosamine-4-sulfatase | False | 4 | 125 | 2 | 9 | Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate | N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase | None | chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase | |
| 3.1.6.13 | iduronate-2-sulfatase | False | 2 | 95 | 2 | 4 | Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin | L-iduronate-2-sulfate 2-sulfohydrolase | None | chondroitinsulfatase; idurono-2-sulfatase; iduronide-2-sulfate sulfatase; L-iduronosulfatase; L-idurono sulfate sulfatase; iduronate sulfatase; sulfo-L-iduronate sulfatase; L-iduronate 2-sulfate sulfatase; sulfoiduronate sulfohydrolase; 2-sulfo-L-iduronate 2-sulfatase; iduronate-2-sulfate sulfatase; iduronate sulfate sulfatase | |
| 3.1.6.14 | N-acetylglucosamine-6-sulfatase | False | 9 | 1421 | 1 | 7 | Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate | N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase | None | chondroitinsulfatase; O,N-disulfate O-sulfohydrolase; acetylglucosamine 6-sulfatase; N-acetylglucosamine 6-sulfate sulfatase; acetylglucosamine 6-sulfatase; 2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase | |
| 3.1.6.15 | N-sulfoglucosamine-3-sulfatase | False | 4 | 1 | 0 | 1 | Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin | N-sulfo-3-sulfoglucosamine 3-sulfohydrolase | None | chondroitinsulfatase | |
| 3.1.6.16 | monomethyl-sulfatase | True | 0 | 0 | 0 | 1 | monomethyl sulfate + H2O = methanol + sulfate | monomethyl-sulfate sulfohydrolase | None | None | |
| 3.1.6.17 | D-lactate-2-sulfatase | True | 0 | 0 | 0 | 1 | (R)-2-O-sulfolactate + H2O = (R)-lactate + sulfate | (R)-2-O-sulfolactate 2-sulfohydrolase | None | (S)-2-O-sulfolactate 2-sulfohydrolase (incorrect stereochemistry) | |
| 3.1.6.18 | glucuronate-2-sulfatase | False | 8 | 474 | 2 | 2 | Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate | polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase | None | glucurono-2-sulfatase | |
| 3.1.7.1 | prenyl-diphosphatase | False | 0 | 10 | 0 | 4 | prenyl diphosphate + H2O = prenol + diphosphate | prenyl-diphosphate diphosphohydrolase | None | prenyl-pyrophosphatase; prenol pyrophosphatase; prenylphosphatase | |
| 3.1.7.2 | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase | False | 19 | 7388 | 4 | 10 | guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate | guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase | None | guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase; PpGpp-3'-pyrophosphohydrolase; PpGpp phosphohydrolase | |
| 3.1.7.3 | monoterpenyl-diphosphatase | False | 0 | 1 | 0 | 1 | a monoterpenyl diphosphate + H2O = a monoterpenol + diphosphate | monoterpenyl-diphosphate diphosphohydrolase | None | bornyl pyrophosphate hydrolase; monoterpenyl-pyrophosphatase | |
| 3.1.8.1 | aryldialkylphosphatase | False | 15 | 166 | 99 | 42 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol | aryltriphosphate dialkylphosphohydrolase | None | organophosphate hydrolase; paraoxonase; A-esterase; aryltriphosphatase; organophosphate esterase; esterase B1; esterase E4; paraoxon esterase; pirimiphos-methyloxon esterase; OPA anhydrase (ambiguous); organophosphorus hydrolase; phosphotriesterase; paraoxon hydrolase; OPH; organophosphorus acid anhydrase | |
| 3.1.11.1 | exodeoxyribonuclease I | False | 50 | 12040 | 20 | 11 | Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates | None | None | Escherichia coli exonuclease I; E. coli exonuclease I; exonuclease I | |
| 3.1.11.2 | exodeoxyribonuclease III | False | 37 | 27377 | 82 | 7 | Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates | None | None | Escherichia coli exonuclease III; E. coli exonuclease III; endoribonuclease III | |
| 3.1.11.3 | exodeoxyribonuclease (lambda-induced) | False | 6 | 567 | 13 | 6 | Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates | None | None | lambda exonuclease; phage lambda-induced exonuclease; Escherichia coli exonuclease IV; E. coli exonuclease IV; exodeoxyribonuclease IV; exonuclease IV | |
| 3.1.11.4 | exodeoxyribonuclease (phage SP3-induced) | False | 0 | 5 | 0 | 1 | Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates | None | None | phage SP3 DNase; DNA 5'-dinucleotidohydrolase; deoxyribonucleate 5'-dinucleotidase; deoxyribonucleic 5'-dinucleotidohydrolase; bacteriophage SP3 deoxyribonuclease; deoxyribonucleate 5'-dinucleotidase | |
| 3.1.11.5 | exodeoxyribonuclease V | False | 12 | 11829 | 18 | 16 | Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides | None | None | Escherichia coli exonuclease V; E. coli exonuclease V; gene recBC endoenzyme; RecBC deoxyribonuclease; gene recBC DNase; exonuclease V; gene recBCD enzymes | |
| 3.1.11.6 | exodeoxyribonuclease VII | False | 853 | 71428 | 1 | 3 | Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates | None | None | Escherichia coli exonuclease VII; E. coli exonuclease VII; endodeoxyribonuclease VII; exonuclease VII | |
| 3.1.13.1 | exoribonuclease II | False | 134 | 33161 | 12 | 29 | Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates | None | None | ribonuclease II; ribonuclease Q; BN ribonuclease; Escherichia coli exo-RNase II; RNase II; exoribonuclease (misleading); 5'-exoribonuclease (misleading) | |
| 3.1.13.2 | exoribonuclease H | False | 75 | 3 | 2 | 29 | 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid | None | None | None | |
| 3.1.13.3 | oligonucleotidase | False | 0 | 233 | 3 | 13 | Exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates | None | None | oligoribonuclease | |
| 3.1.13.4 | poly(A)-specific ribonuclease | False | 108 | 17941 | 30 | 14 | Exonucleolytic cleavage of poly(A) to 5'-AMP | None | None | 3'-exoribonuclease; 2',3'-exoribonuclease | |
| 3.1.14.1 | yeast ribonuclease | True | 0 | 0 | 0 | 9 | Exonucleolytic cleavage to nucleoside 3'-phosphates | None | None | None | |
| 3.1.15.1 | venom exonuclease | True | 0 | 0 | 0 | 74 | Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates | None | None | venom phosphodiesterase | |
| 3.1.16.1 | spleen exonuclease | False | 10 | 801 | 2 | 10 | Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates | None | None | 3'-exonuclease; spleen phosphodiesterase; 3'-nucleotide phosphodiesterase; phosphodiesterase II | |
| 3.1.21.1 | deoxyribonuclease I | False | 18 | 1741 | 54 | 51 | Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products | None | None | pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease | |
| 3.1.21.2 | deoxyribonuclease IV | False | 271 | 17410 | 21 | 9 | Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products | None | None | deoxyribonuclease IV (phage-T4-induced) (misleading); endodeoxyribonuclease IV (phage T4-induced) (misleading); E. coli endonuclease IV; endodeoxyribonuclease (misleading); redoxyendonuclease; deoxriboendonuclease (misleading); endonuclease II; endonuclease IV; DNA-adenine-transferase; nfo (gene name) | |
| 3.1.21.3 | type I site-specific deoxyribonuclease | False | 17 | 36144 | 10 | 14 | Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolysed | None | None | type I restriction enzyme; deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent); restriction-modification system; deoxyribonuclease (adenosine triphosphate-hydrolyzing); adenosine triphosphate-dependent deoxyribonuclease; ATP-dependent DNase; type 1 site-specific deoxyribonuclease | |
| 3.1.21.4 | type II site-specific deoxyribonuclease | False | 114 | 3109 | 130 | 142 | Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates | None | None | type II restriction enzyme | |
| 3.1.21.5 | type III site-specific deoxyribonuclease | False | 5 | 640 | 1 | 16 | Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates | None | None | type III restriction enzyme; restriction-modification system | |
| 3.1.21.6 | CC-preferring endodeoxyribonuclease | True | 0 | 0 | 0 | 4 | endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC | None | None | Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease | |
| 3.1.21.7 | deoxyribonuclease V | False | 128 | 8005 | 9 | 12 | Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate | None | None | endodeoxyribonuclease V; DNase V; Escherichia coli endodeoxyribonuclease V | |
| 3.1.22.1 | deoxyribonuclease II | False | 10 | 1538 | 0 | 27 | Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products | None | None | DNase II; pancreatic DNase II; deoxyribonucleate 3'-nucleotidohydrolase; DNase II; pancreatic DNase II; acid deoxyribonuclease; acid DNase | |
| 3.1.22.2 | Aspergillus deoxyribonuclease K1 | True | 0 | 0 | 0 | 1 | Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products | None | None | Aspergillus DNase K1 | |
| 3.1.22.5 | deoxyribonuclease X | True | 0 | 0 | 0 | 1 | Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes | None | None | Escherichia coli endodeoxyribonuclease; Escherichia coli endodeoxyribonuclease X | |
| 3.1.25.1 | deoxyribonuclease (pyrimidine dimer) | False | 0 | 33 | 5 | 7 | Endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate | None | None | endodeoxyribonuclease (pyrimidine dimer); endodeoxyribonuclease (pyrimidine dimer); bacteriophage T4 endodeoxyribonuclease V; T4 endonuclease V | |
| 3.1.26.1 | Physarum polycephalum ribonuclease | False | 1 | 2 | 0 | 1 | Endonucleolytic cleavage to 5'-phosphomonoester | None | None | None | |
| 3.1.26.2 | ribonuclease alpha | True | 0 | 0 | 0 | 1 | Endonucleolytic cleavage to 5'-phosphomonoester | None | None | 2'-O-methyl RNase | |
| 3.1.26.3 | ribonuclease III | False | 516 | 44946 | 49 | 52 | Endonucleolytic cleavage to a 5'-phosphomonoester | None | None | RNase III; ribonuclease 3 | |
| 3.1.26.4 | ribonuclease H | False | 1339 | 123969 | 202 | 49 | Endonucleolytic cleavage to 5'-phosphomonoester | None | None | endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H | |
| 3.1.26.5 | ribonuclease P | False | 703 | 48331 | 63 | 179 | Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor | None | None | RNase P | |
| 3.1.26.6 | ribonuclease IV | True | 0 | 0 | 0 | 3 | Endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups | None | None | endoribonuclease IV; poly(A)-specific ribonuclease | |
| 3.1.26.7 | ribonuclease P4 | True | 0 | 0 | 0 | 2 | Endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor | None | None | None | |
| 3.1.26.8 | ribonuclease M5 | False | 22 | 4367 | 4 | 3 | Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor | None | None | RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease | |
| 3.1.26.9 | ribonuclease [poly-(U)-specific] | True | 0 | 0 | 0 | 4 | Endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups | None | None | ribonuclease (uracil-specific); uracil-specific endoribonuclease; uracil-specific RNase | |
| 3.1.26.10 | ribonuclease IX | True | 0 | 0 | 0 | 3 | Endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups | None | None | poly(U)- and poly(C)-specific endoribonuclease | |
| 3.1.26.11 | tRNase Z | False | 293 | 23108 | 8 | 74 | endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule | None | None | 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase | |
| 4.2.3.197 | eudesmane-5,11-diol synthase | False | 2 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 7-epi-ent-eudesmane-5,11-diol-forming) | None | ZmEDS (gene name) | |
| 4.2.3.196 | dolabradiene synthase | False | 1 | 0 | 0 | 1 | ent-copalyl diphosphate = dolabradiene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (dolabradiene-forming) | None | KSL4 (gene name) | |
| 3.1.27.7 | ribonuclease F | True | 0 | 0 | 0 | 3 | Endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups | None | None | ribonuclease F (E. coli) | |
| 3.1.27.8 | ribonuclease V | True | 0 | 0 | 0 | 2 | Hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP | None | None | endoribonuclease V | |
| 3.1.30.1 | Aspergillus nuclease S1 | False | 7 | 1806 | 15 | 27 | Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products | None | None | endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease | |
| 3.1.30.2 | Serratia marcescens nuclease | False | 1 | 33 | 5 | 17 | Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products | None | None | endonuclease (Serratia marcescens); barley nuclease; plant nuclease I; nucleate endonuclease | |
| 3.1.31.1 | micrococcal nuclease | False | 16 | 2288 | 317 | 10 | Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products | None | None | spleen endonuclease; thermonuclease; nuclease T; micrococcal endonuclease; nuclease T'; staphylococcal nuclease; spleen phosphodiesterase; Staphylococcus aureus nuclease; Staphylococcus aureus nuclease B; ribonucleate (deoxynucleate) 3'-nucleotidohydrolase | |
| 3.2.1.1 | alpha-amylase | False | 137 | 27696 | 208 | 251 | Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units | 4-alpha-D-glucan glucanohydrolase | None | glycogenase; alpha amylase; endoamylase; Taka-amylase A; 1,4-alpha-D-glucan glucanohydrolase | |
| 3.2.1.2 | beta-amylase | False | 24 | 5694 | 53 | 62 | Hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains | 4-alpha-D-glucan maltohydrolase | None | saccharogen amylase; glycogenase; beta amylase; 1,4-alpha-D-glucan maltohydrolase | |
| 3.2.1.3 | glucan 1,4-alpha-glucosidase | False | 24 | 4111 | 27 | 98 | Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose | 4-alpha-D-glucan glucohydrolase | None | glucoamylase; amyloglucosidase; gamma-amylase; lysosomal alpha-glucosidase; acid maltase; exo-1,4-alpha-glucosidase; glucose amylase; gamma-1,4-glucan glucohydrolase; acid maltase; 1,4-alpha-D-glucan glucohydrolase | |
| 3.2.1.4 | cellulase | False | 302 | 46342 | 327 | 236 | Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans | 4-beta-D-glucan 4-glucanohydrolase | None | endo-1,4-beta-D-glucanase; beta-1,4-glucanase; beta-1,4-endoglucan hydrolase; celluase A; cellulosin AP; endoglucanase D; alkali cellulase; cellulase A 3; celludextrinase; 9.5 cellulase; avicelase; pancellase SS; 1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase | |
| 3.2.1.6 | endo-1,3(4)-beta-glucanase | False | 12 | 286 | 8 | 53 | Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3 | 3(or 4)-beta-D-glucan 3(4)-glucanohydrolase | None | endo-1,3-beta-D-glucanase; laminarinase; laminaranase; beta-1,3-glucanase; beta-1,3-1,4-glucanase; endo-1,3-beta-glucanase; endo-beta-1,3(4)-glucanase; endo-beta-1,3-1,4-glucanase; endo-beta-(1->3)-D-glucanase; endo-1,3-1,4-beta-D-glucanase; endo-beta-(1-3)-D-glucanase; endo-beta-1,3-glucanase IV; endo-1,3-beta-D-glucanase; 1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase | |
| 3.2.1.7 | inulinase | False | 5 | 10 | 2 | 39 | Endohydrolysis of (2->1)-beta-D-fructosidic linkages in inulin | 1-beta-D-fructan fructanohydrolase | None | inulase; indoinulinase; endo-inulinase; exoinulinase; 2,1-beta-D-fructan fructanohydrolase | |
| 3.2.1.8 | endo-1,4-beta-xylanase | False | 171 | 24366 | 424 | 207 | Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans | 4-beta-D-xylan xylanohydrolase | None | endo-(1->4)-beta-xylan 4-xylanohydrolase; endo-1,4-xylanase; xylanase; beta-1,4-xylanase; endo-1,4-xylanase; endo-beta-1,4-xylanase; endo-1,4-beta-D-xylanase; 1,4-beta-xylan xylanohydrolase; beta-xylanase; beta-1,4-xylan xylanohydrolase; endo-1,4-beta-xylanase; beta-D-xylanase | |
| 3.2.1.10 | oligo-1,6-glucosidase | False | 18 | 2657 | 14 | 34 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by EC 3.2.1.1 (alpha-amylase), and in isomaltose | oligosaccharide 6-alpha-glucohydrolase | None | limit dextrinase (erroneous); isomaltase; sucrase-isomaltase; exo-oligo-1,6-glucosidase; dextrin 6alpha-glucanohydrolase; alpha-limit dextrinase; dextrin 6-glucanohydrolase; oligosaccharide alpha-1,6-glucohydrolase; alpha-methylglucosidase | |
| 3.2.1.11 | dextranase | False | 7 | 78 | 8 | 58 | Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran | 6-alpha-D-glucan 6-glucanohydrolase | None | dextran hydrolase; endodextranase; dextranase DL 2; DL 2; endo-dextranase; alpha-D-1,6-glucan-6-glucanohydrolase; 1,6-alpha-D-glucan 6-glucanohydrolase | |
| 3.2.1.14 | chitinase | False | 192 | 32500 | 254 | 234 | Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins | (1->4)-2-acetamido-2-deoxy-beta-D-glucan glycanohydrolase | None | ChiC; chitodextrinase (ambiguous); 1,4-beta-poly-N-acetylglucosaminidase; poly-beta-glucosaminidase; beta-1,4-poly-N-acetyl glucosamidinase; poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase | |
| 3.2.1.15 | endo-polygalacturonase | False | 89 | 6089 | 12 | 110 | (1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m | (1->4)-alpha-D-galacturonan glycanohydrolase (endo-cleaving) | None | pectin depolymerase (ambiguous); pectinase (ambiguous); endopolygalacturonase; pectolase (ambiguous); pectin hydrolase (ambiguous); pectin polygalacturonase (ambiguous); polygalacturonase (ambiguous); poly-alpha-1,4-galacturonide glycanohydrolase (ambiguous); endogalacturonase; endo-D-galacturonase; poly(1,4-alpha-D-galacturonide) glycanohydrolase (ambiguous) | |
| 3.2.1.17 | lysozyme | False | 204 | 28931 | 2311 | 102 | Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins | peptidoglycan N-acetylmuramoylhydrolase | None | muramidase; globulin G; mucopeptide glucohydrolase; globulin G1; N,O-diacetylmuramidase; lysozyme g; L-7001; 1,4-N-acetylmuramidase; mucopeptide N-acetylmuramoylhydrolase; PR1-lysozyme | |
| 3.2.1.18 | exo-alpha-sialidase | False | 218 | 115833 | 368 | 71 | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates | acetylneuraminyl hydrolase | None | neuraminidase; sialidase; alpha-neuraminidase; acetylneuraminidase | |
| 3.2.1.20 | alpha-glucosidase | False | 51 | 12416 | 66 | 130 | Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of D-glucose | alpha-D-glucoside glucohydrolase | None | maltase; glucoinvertase; glucosidosucrase; maltase-glucoamylase; alpha-glucopyranosidase; glucosidoinvertase; alpha-D-glucosidase; alpha-glucoside hydrolase; alpha-1,4-glucosidase | |
| 3.2.1.21 | beta-glucosidase | False | 220 | 72110 | 222 | 255 | Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose | beta-D-glucoside glucohydrolase | None | gentiobiase; cellobiase; emulsin; elaterase; aryl-beta-glucosidase; beta-D-glucosidase; beta-glucoside glucohydrolase; arbutinase; amygdalinase; p-nitrophenyl beta-glucosidase; primeverosidase; amygdalase; linamarase; salicilinase; beta-1,6-glucosidase | |
| 3.2.1.22 | alpha-galactosidase | False | 88 | 34965 | 78 | 143 | Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids | alpha-D-galactoside galactohydrolase | None | melibiase; alpha-D-galactosidase; alpha-galactosidase A; alpha-galactoside galactohydrolase | |
| 3.2.1.23 | beta-galactosidase | False | 198 | 62386 | 189 | 241 | Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides | beta-D-galactoside galactohydrolase | None | lactase (ambiguous); beta-lactosidase; maxilact; hydrolact; beta-D-lactosidase; S 2107; lactozym; trilactase; beta-D-galactanase; oryzatym; sumiklat | |
| 3.2.1.24 | alpha-mannosidase | False | 28 | 4289 | 13 | 55 | Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides | alpha-D-mannoside mannohydrolase | None | alpha-D-mannosidase; p-nitrophenyl-alpha-mannosidase; alpha-D-mannopyranosidase; 1,2-alpha-mannosidase; 1,2-alpha-D-mannosidase; exo-alpha-mannosidase | |
| 3.2.1.25 | beta-mannosidase | False | 27 | 13717 | 25 | 48 | Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides | beta-D-mannoside mannohydrolase | None | mannanase; mannase; beta-D-mannosidase; beta-mannoside mannohydrolase; exo-beta-D-mannanase | |
| 3.2.1.26 | beta-fructofuranosidase | False | 75 | 21200 | 49 | 133 | Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides | beta-D-fructofuranoside fructohydrolase | None | invertase; saccharase; glucosucrase; beta-h-fructosidase; beta-fructosidase; invertin; sucrase; maxinvert L 1000; fructosylinvertase; alkaline invertase; acid invertase | |
| 3.2.1.28 | alpha,alpha-trehalase | False | 117 | 11924 | 13 | 77 | alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose | alpha,alpha-trehalose glucohydrolase | None | trehalase | |
| 3.2.1.31 | beta-glucuronidase | False | 22 | 5516 | 50 | 51 | a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol | beta-D-glucuronoside glucuronosohydrolase | None | beta-glucuronide glucuronohydrolase glucuronidase; exo-beta-D-glucuronidase; ketodase | |
| 3.2.1.32 | endo-1,3-beta-xylanase | False | 3 | 16 | 1 | 10 | Random endohydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans | 3-beta-D-xylan xylanohydrolase | None | xylanase (ambiguous); endo-1,3-beta-xylosidase (misleading); 1,3-beta-xylanase; 1,3-xylanase; beta-1,3-xylanase; endo-beta-1,3-xylanase; 1,3-beta-D-xylan xylanohydrolase; xylan endo-1,3-beta-xylosidase | |
| 3.2.1.33 | amylo-alpha-1,6-glucosidase | False | 5 | 2609 | 1 | 15 | Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin | glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase | None | amylo-1,6-glucosidase; dextrin 6-alpha-D-glucosidase; amylopectin 1,6-glucosidase; dextrin-1,6-glucosidase; glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase | |
| 3.2.1.35 | hyaluronoglucosaminidase | False | 60 | 7240 | 22 | 61 | Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate | hyaluronate 4-glycanohydrolase | None | hyaluronidase; hyaluronoglucosidase; chondroitinase; chondroitinase I | |
| 3.2.1.36 | hyaluronoglucuronidase | False | 1 | 0 | 1 | 32 | Random hydrolysis of (1->3)-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate | hyaluronate 3-glycanohydrolase | None | hyaluronidase; glucuronoglucosaminoglycan hyaluronate lyase; orgelase | |
| 3.2.1.37 | xylan 1,4-beta-xylosidase | False | 43 | 3833 | 43 | 98 | Hydrolysis of (1->4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini | 4-beta-D-xylan xylohydrolase | None | xylobiase; beta-xylosidase; exo-1,4-beta-xylosidase; beta-D-xylopyranosidase; beta-xylosidase; beta-xylosidase; exo-1,4-xylosidase; exo-1,4-beta-D-xylosidase; 1,4-beta-D-xylan xylohydrolase | |
| 3.2.1.38 | beta-D-fucosidase | False | 1 | 17 | 0 | 25 | Hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides | beta-D-fucoside fucohydrolase | None | beta-fucosidase | |
| 3.2.1.39 | glucan endo-1,3-beta-D-glucosidase | False | 102 | 23614 | 39 | 106 | Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans | 3-beta-D-glucan glucanohydrolase | None | endo-1,3-beta-glucanase; laminarinase; laminaranase; oligo-1,3-glucosidase; endo-1,3-beta-glucanase; callase; beta-1,3-glucanase; kitalase; 1,3-beta-D-glucan 3-glucanohydrolase; endo-(1,3)-beta-D-glucanase; (1->3)-beta-glucan 3-glucanohydrolase; endo-1,3-beta-D-glucanase; endo-1,3-beta-glucosidase; 1,3-beta-D-glucan glucanohydrolase | |
| 3.2.1.40 | alpha-L-rhamnosidase | False | 6 | 28137 | 5 | 38 | Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides | alpha-L-rhamnoside rhamnohydrolase | None | alpha-L-rhamnosidase T; alpha-L-rhamnosidase N | |
| 3.2.1.41 | pullulanase | False | 11 | 7763 | 39 | 64 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen | pullulan 6-alpha-glucanohydrolase | None | limit dextrinase (erroneous); amylopectin 6-glucanohydrolase; bacterial debranching enzyme; debranching enzyme; alpha-dextrin endo-1,6-alpha-glucosidase; R-enzyme; pullulan alpha-1,6-glucanohydrolase | |
| 3.2.1.42 | GDP-glucosidase | False | 0 | 90 | 0 | 1 | GDP-glucose + H2O = D-glucose + GDP | GDP-glucose glucohydrolase | None | guanosine diphosphoglucosidase; guanosine diphosphate D-glucose glucohydrolase | |
| 3.2.1.43 | beta-L-rhamnosidase | True | 0 | 0 | 0 | 1 | Hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides | beta-L-rhamnoside rhamnohydrolase | None | None | |
| 3.2.1.45 | glucosylceramidase | False | 20 | 6885 | 64 | 8 | a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide | D-glucosyl-N-acylsphingosine glucohydrolase | None | psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-beta-glucosidase; beta-D-glucocerebrosidase; glucosylcerebrosidase; beta-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine beta-glucosidase; glucosylsphingosine beta-D-glucosidase | |
| 3.2.1.46 | galactosylceramidase | False | 21 | 2234 | 14 | 4 | a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide | D-galactosyl-N-acylsphingosine galactohydrolase | None | cerebroside galactosidase; galactocerebroside.beta-galactosidase; galactosylcerebrosidase; galactocerebrosidase; ceramide galactosidase; galactocerebroside galactosidase; galactosylceramide.beta-galactosidase; cerebroside beta-galactosidase; galactosylceramidase I; beta-galactosylceramidase; galactocerebroside-beta-D-galactosidase; lactosylceramidase I; beta-galactocerebrosidase; lactosylceramidase | |
| 3.2.1.48 | sucrose alpha-glucosidase | False | 5 | 11 | 4 | 24 | Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action | sucrose-alpha-D-glucohydrolase | None | sucrose alpha-glucohydrolase; sucrase; sucrase-isomaltase; sucrose.alpha.-glucohydrolase; intestinal sucrase; sucrase(invertase) | |
| 3.2.1.49 | alpha-N-acetylgalactosaminidase | False | 10 | 261 | 16 | 41 | Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids | alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase | None | alpha-acetylgalactosaminidase; N-acetyl-alpha-D-galactosaminidase; N-acetyl-alpha-galactosaminidase; alpha-NAGAL; alpha-NAGA; alpha-GalNAcase | |
| 3.2.1.50 | alpha-N-acetylglucosaminidase | False | 2 | 215 | 12 | 12 | Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides | alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase | None | alpha-acetylglucosaminidase; N-acetyl-alpha-D-glucosaminidase; N-acetyl-alpha-glucosaminidase; alpha-D-2-acetamido-2-deoxyglucosidase | |
| 3.2.1.51 | alpha-L-fucosidase | False | 21 | 7943 | 22 | 93 | an alpha-L-fucoside + H2O = L-fucose + an alcohol | alpha-L-fucoside fucohydrolase | None | alpha-fucosidase | |
| 3.2.1.52 | beta-N-acetylhexosaminidase | False | 170 | 78907 | 163 | 133 | Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides | beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase | None | hexosaminidase; beta-acetylaminodeoxyhexosidase; N-acetyl-beta-D-hexosaminidase; N-acetyl-beta-hexosaminidase; beta-hexosaminidase; beta-acetylhexosaminidinase; beta-D-N-acetylhexosaminidase; beta-N-acetyl-D-hexosaminidase; beta-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; beta-D-hexosaminidase; NAHase | |
| 3.2.1.53 | beta-N-acetylgalactosaminidase | False | 0 | 2 | 2 | 8 | Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides | beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase | None | N-acetyl-beta-galactosaminidase; N-acetyl-beta-D-galactosaminidase; beta-acetylgalactosaminidase; beta-D-N-acetylgalactosaminidase; N-acetylgalactosaminidase | |
| 3.2.1.54 | cyclomaltodextrinase | False | 6 | 484 | 10 | 39 | cyclomaltodextrin + H2O = linear maltodextrin | cyclomaltodextrin dextrin-hydrolase (ring-opening) | None | cycloheptaglucanase; cyclohexaglucanase; cyclodextrinase; cyclomaltodextrin dextrin-hydrolase (decyclizing) | |
| 3.2.1.55 | non-reducing end alpha-L-arabinofuranosidase | False | 70 | 16550 | 79 | 136 | Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. | alpha-L-arabinofuranoside non-reducing end alpha-L-arabinofuranosidase | None | arabinosidase (ambiguous); alpha-arabinosidase; alpha-L-arabinosidase; alpha-arabinofuranosidase; polysaccharide alpha-L-arabinofuranosidase; alpha-L-arabinofuranoside hydrolase; L-arabinosidase (ambiguous); alpha-L-arabinanase | |
| 3.2.1.56 | glucuronosyl-disulfoglucosamine glucuronidase | True | 0 | 0 | 0 | 1 | 3-D-glucuronosyl-N2,6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N2,6-disulfo-D-glucosamine | 3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase | None | glycuronidase; 3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase | |
| 3.2.1.57 | isopullulanase | False | 1 | 1 | 4 | 5 | Hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose) | pullulan 4-glucanohydrolase (isopanose-forming) | None | None | |
| 3.2.1.58 | glucan 1,3-beta-glucosidase | False | 46 | 6268 | 26 | 62 | Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose | 3-beta-D-glucan glucohydrolase | None | exo-1,3-beta-glucosidase; beta-1,3-glucan exo-hydrolase; exo (1->3)-glucanohydrolase; 1,3-beta-glucan glucohydrolase | |
| 3.2.1.59 | glucan endo-1,3-alpha-glucosidase | False | 3 | 18 | 1 | 19 | Endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran | 3-alpha-D-glucan 3-glucanohydrolase | None | endo-1,3-alpha-glucanase; mutanase; endo-(1->3)-alpha-glucanase; cariogenase; cariogenanase; endo-1,3-alpha-D-glucanase; 1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase | |
| 3.2.1.60 | glucan 1,4-alpha-maltotetraohydrolase | False | 2 | 10 | 13 | 6 | Hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends | 4-alpha-D-glucan maltotetraohydrolase | None | exo-maltotetraohydrolase; 1,4-alpha-D-glucan maltotetraohydrolase | |
| 3.2.1.61 | mycodextranase | False | 0 | 3 | 0 | 7 | Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in alpha-D-glucans containing both (1->3)- and (1->4)-bonds | (1->3)-(1->4)-alpha-D-glucan 4-glucanohydrolase | None | 1,3-1,4-alpha-D-glucan 4-glucanohydrolase | |
| 3.2.1.62 | glycosylceramidase | False | 4 | 19 | 0 | 14 | (1) a beta-D-glucosyl-N-acylsphingosine + H2O = a ceramide + beta-D-glucose;;(2) a beta-D-galactosyl-N-acylsphingosine + H2O = a ceramide + beta-D-galactose;;(3) a flavonoid-O-beta-D-glucoside + H2O = a flavonoid + beta-D-glucose | beta-D-glucosyl-N-acylsphingosine glycohydrolase (configuration-retaining) | None | phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin beta-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase; LPH (gene name); LCT (gene name); glycosyl-N-acylsphingosine glycohydrolase | |
| 3.2.1.63 | 1,2-alpha-L-fucosidase | False | 0 | 11 | 4 | 12 | methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H2O = L-fucose + methyl beta-D-galactoside | 2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase | None | almond emulsin fucosidase; alpha-(1->2)-L-fucosidase | |
| 3.2.1.64 | 2,6-beta-fructan 6-levanbiohydrolase | False | 2 | 85 | 0 | 3 | Hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain | (2->6)-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase | None | beta-2,6-fructan-6-levanbiohydrolase; 2,6-beta-D-fructan 6-levanbiohydrolase; levanbiose-producing levanase; 2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase | |
| 3.2.1.65 | levanase | False | 1 | 169 | 0 | 26 | Random hydrolysis of (2->6)-beta-D-fructofuranosidic linkages in (2->6)-beta-D-fructans (levans) containing more than 3 fructose units | (2->6)-beta-D-fructan fructanohydrolase | None | levan hydrolase; 2,6-beta-D-fructan fructanohydrolase | |
| 3.2.1.67 | galacturonan 1,4-alpha-galacturonidase | False | 52 | 5191 | 1 | 61 | [(1->4)-alpha-D-galacturonide]n + H2O = [(1->4)-alpha-D-galacturonide]n-1 + D-galacturonate | poly[(1->4)-alpha-D-galacturonide] non-reducing-end galacturonohydrolase | None | exo-polygalacturonase; poly(galacturonate) hydrolase (ambiguous); exo-D-galacturonase; exo-D-galacturonanase; exopoly-D-galacturonase; poly(1,4-alpha-D-galacturonide) galacturonohydrolase (ambiguous); pgaA (gene name); pgaB (gene name); pgaC (gene name); pgaD (gene name); pgaE (gene name); pgaI (gene name); pgaII (gene name); poly[(1->4)-alpha-D-galacturonide] galacturonohydrolase; galacturan 1,4-alpha-galacturonidase (incorrect) | |
| 3.2.1.68 | isoamylase | False | 9 | 299 | 3 | 27 | Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limit dextrins | glycogen 6-alpha-D-glucanohydrolase | None | debranching enzyme; glycogen alpha-1,6-glucanohydrolase | |
| 3.2.1.70 | glucan 1,6-alpha-glucosidase | False | 3 | 363 | 10 | 11 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides | glucan 6-alpha-D-glucohydrolase | None | exo-1,6-beta-glucosidase; glucodextrinase; glucan alpha-1,6-D-glucohydrolase | |
| 3.2.1.71 | glucan endo-1,2-beta-glucosidase | False | 0 | 4 | 3 | 15 | Random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans | 2-beta-D-glucan glucanohydrolase | None | endo-1,2-beta-glucanase; beta-D-1,2-glucanase; endo-(1->2)-beta-D-glucanase; 1,2-beta-D-glucan glucanohydrolase | |
| 3.2.1.72 | xylan 1,3-beta-xylosidase | False | 1 | 21 | 0 | 3 | Hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans | 3-beta-D-xylan xylohydrolase | None | 1,3-beta-D-xylosidase; exo-1,3-beta-xylosidase; beta-1,3'-xylanase; exo-beta-1,3'-xylanase; 1,3-beta-D-xylan xylohydrolase | |
| 3.2.1.73 | licheninase | False | 15 | 2261 | 43 | 54 | Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3)- and (1->4)-bonds | (1->3)-(1->4)-beta-D-glucan 4-glucanohydrolase | None | lichenase; beta-(1->4)-D-glucan 4-glucanohydrolase; 1,3;1,4-beta-glucan endohydrolase; 1,3;1,4-beta-glucan 4-glucanohydrolase; 1,3-1,4-beta-D-glucan 4-glucanohydrolase | |
| 3.2.1.74 | glucan 1,4-beta-glucosidase | False | 3 | 28 | 2 | 75 | Hydrolysis of (1->4)-linkages in (1->4)-beta-D-glucans, to remove successive glucose units | 4-beta-D-glucan glucohydrolase | None | exo-1,4-beta-glucosidase; exocellulase; exo-beta-1,4-glucosidase; exo-beta-1,4-glucanase; beta-1,4-beta-glucanase; beta-glucosidase; exo-1,4-beta-glucanase; 1,4-beta-D-glucan glucohydrolase | |
| 3.2.1.75 | glucan endo-1,6-beta-glucosidase | False | 11 | 1201 | 0 | 37 | Random hydrolysis of (1->6)-linkages in (1->6)-beta-D-glucans | 6-beta-D-glucan glucanohydrolase | None | endo-1,6-beta-glucanase; beta-1->6)-beta-D-glucanase; beta-1,6-glucanase-pustulanase; beta-1,6-glucan hydrolase; beta-1,6-glucan 6-glucanohydrolase; 1,6-beta-D-glucan glucanohydrolase | |
| 3.2.1.76 | L-iduronidase | False | 4 | 21 | 11 | 7 | Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate | glycosaminoglycan alpha-L-iduronohydrolase | None | alpha-L-iduronidase | |
| 3.2.1.77 | mannan 1,2-(1,3)-alpha-mannosidase | True | 0 | 0 | 0 | 7 | Hydrolysis of (1->2)- and (1->3)-linkages in yeast mannan, releasing mannose | (1->2)-(1->3)-alpha-D-mannan mannohydrolase | None | exo-1,2-1,3-alpha-mannosidase; 1,2-1,3-alpha-D-mannan mannohydrolase | |
| 3.2.1.78 | mannan endo-1,4-beta-mannosidase | False | 61 | 8997 | 53 | 94 | Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans | 4-beta-D-mannan mannanohydrolase | None | endo-1,4-beta-mannanase; endo-beta-1,4-mannase; beta-mannanase B; beta-1,4-mannan 4-mannanohydrolase; endo-beta-mannanase; beta-D-mannanase; 1,4-beta-D-mannan mannanohydrolase | |
| 3.2.1.80 | fructan beta-fructosidase | False | 10 | 461 | 7 | 33 | Hydrolysis of terminal, non-reducing (2->1)- and (2->6)-linked beta-D-fructofuranose residues in fructans | beta-D-fructan fructohydrolase | None | exo-beta-D-fructosidase; exo-beta-fructosidase; polysaccharide beta-fructofuranosidase; fructan exohydrolase | |
| 3.2.1.81 | beta-agarase | False | 11 | 157 | 12 | 24 | Hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product | agarose 4-glycanohydrolase | None | agarase (ambiguous); AgaA; AgaB; endo-beta-agarase; agarose 3-glycanohydrolase (incorrect) | |
| 3.2.1.82 | exo-poly-alpha-digalacturonosidase | False | 1 | 389 | 0 | 10 | [(1->4)-alpha-D-galacturonosyl]n + H2O = alpha-D-galacturonosyl-(1->4)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl]n-2 | poly[(1->4)-alpha-D-galactosiduronate] non-reducing-end-digalacturonohydrolase | None | pehX (gene name); poly(1,4-alpha-D-galactosiduronate) digalacturonohydrolase; exopolygalacturonosidase (misleading); poly[(1->4)-alpha-D-galactosiduronate] digalacturonohydrolase; exo-poly-alpha-galacturonosidase | |
| 3.2.1.83 | kappa-carrageenase | False | 1 | 257 | 3 | 55 | Endohydrolysis of (1->4)-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans | kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) | None | kappa-carrageenan 4-beta-D-glycanohydrolase | |
| 3.2.1.84 | glucan 1,3-alpha-glucosidase | False | 1 | 40 | 10 | 8 | Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans | 3-alpha-D-glucan 3-glucohydrolase | None | exo-1,3-alpha-glucanase; glucosidase II; 1,3-alpha-D-glucan 3-glucohydrolase | |
| 3.2.1.85 | 6-phospho-beta-galactosidase | False | 49 | 1209 | 22 | 17 | a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol | 6-phospho-beta-D-galactoside 6-phosphogalactohydrolase | None | phospho-beta-galactosidase; beta-D-phosphogalactoside galactohydrolase; phospho-beta-D-galactosidase; 6-phospho-beta-D-galactosidase | |
| 3.2.1.86 | 6-phospho-beta-glucosidase | False | 12 | 7605 | 12 | 22 | 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate | 6-phospho-beta-D-glucosyl-(1->4)-D-glucose glucohydrolase | None | phospho-beta-glucosidase A; phospho-beta-glucosidase; phosphocellobiase; 6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase | |
| 3.2.1.87 | capsular-polysaccharide endo-1,3-alpha-galactosidase | True | 0 | 0 | 0 | 5 | Random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide | Aerobacter-capsular-polysaccharide galactohydrolase | None | polysaccharide depolymerase; capsular polysaccharide galactohydrolase | |
| 3.2.1.88 | non-reducing end beta-L-arabinopyranosidase | False | 0 | 1 | 0 | 3 | Removal of a terminal beta-L-arabinopyranose residue from the non-reducing end of its substrate. | beta-L-arabinopyranoside non-reducing end beta-L-arabinopyranosidase | None | vicianosidase; beta-L-arabinosidase (ambiguous); beta-L-arabinoside arabinohydrolase (ambiguous) | |
| 3.2.1.89 | arabinogalactan endo-beta-1,4-galactanase | False | 16 | 7087 | 16 | 16 | The enzyme specifically hydrolyses (1->4)-beta-D-galactosidic linkages in type I arabinogalactans. | arabinogalactan 4-beta-D-galactanohydrolase | None | endo-1,4-beta-galactanase; galactanase (ambiguous); arabinogalactanase; ganB (gene name) | |
| 3.2.1.91 | cellulose 1,4-beta-cellobiosidase (non-reducing end) | False | 59 | 1153 | 139 | 57 | Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains | 4-beta-D-glucan cellobiohydrolase (non-reducing end) | None | exo-cellobiohydrolase; beta-1,4-glucan cellobiohydrolase; beta-1,4-glucan cellobiosylhydrolase; 1,4-beta-glucan cellobiosidase; exoglucanase; avicelase; CBH 1; C1 cellulase; cellobiohydrolase I; cellobiohydrolase; exo-beta-1,4-glucan cellobiohydrolase; 1,4-beta-D-glucan cellobiohydrolase; cellobiosidase | |
| 3.2.1.92 | peptidoglycan beta-N-acetylmuramidase | False | 1 | 34 | 0 | 1 | Hydrolysis of terminal, non-reducing N-acetylmuramic residues | peptidoglycan beta-N-acetylmuramoylexohydrolase | None | exo-beta-N-acetylmuramidase; exo-beta-acetylmuramidase; beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase | |
| 3.2.1.93 | alpha,alpha-phosphotrehalase | False | 2 | 5299 | 2 | 5 | alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate | alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase | None | phosphotrehalase | |
| 3.2.1.94 | glucan 1,6-alpha-isomaltosidase | False | 1 | 26 | 0 | 3 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains | 6-alpha-D-glucan isomaltohydrolase | None | exo-isomaltohydrolase; isomalto-dextranase; isomaltodextranase; G2-dextranase; 1,6-alpha-D-glucan isomaltohydrolase | |
| 3.2.1.95 | dextran 1,6-alpha-isomaltotriosidase | False | 0 | 2 | 0 | 1 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains | 6-alpha-D-glucan isomaltotriohydrolase | None | exo-isomaltotriohydrolase; 1,6-alpha-D-glucan isomaltotriohydrolase | |
| 3.2.1.96 | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase | False | 30 | 4287 | 31 | 53 | Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn- structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact | glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase | None | N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase; endo-beta-N-acetylglucosaminidase; mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; di-N-acetylchitobiosyl beta-N-acetylglucosaminidase; endo-beta-acetylglucosaminidase; endo-beta-(1->4)-N-acetylglucosaminidase; mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase; endoglycosidase S; endo-N-acetyl-beta-D-glucosaminidase; endo-N-acetyl-beta-glucosaminidase; endo-beta-N-acetylglucosaminidase D; endo-beta-N-acetylglucosaminidase F; endo-beta-N-acetylglucosaminidase H; endo-beta-N-acetylglucosaminidase L; glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase; endoglycosidase H | |
| 3.2.1.97 | endo-alpha-N-acetylgalactosaminidase | False | 3 | 194 | 7 | 12 | beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-[glycoprotein]-L-serine/L-threonine + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + [glycoprotein]-L-serine/L-threonine | glycopeptide-D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase | None | endo-alpha-acetylgalactosaminidase; endo-alpha-N-acetyl-D-galactosaminidase; mucinaminylserine mucinaminidase; D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine mucinaminohydrolase; endo-alpha-GalNAc-ase; glycopeptide alpha-N-acetylgalactosaminidase; D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase | |
| 3.2.1.98 | glucan 1,4-alpha-maltohexaosidase | False | 1 | 168 | 4 | 11 | Hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends | 4-alpha-D-glucan maltohexaohydrolase | None | exo-maltohexaohydrolase; 1,4-alpha-D-glucan maltohexaohydrolase | |
| 3.2.1.99 | arabinan endo-1,5-alpha-L-arabinanase | False | 33 | 2686 | 22 | 24 | Endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5)-arabinans | 5-alpha-L-arabinan 5-alpha-L-arabinanohydrolase | None | endo-1,5-alpha-L-arabinanase; endo-alpha-1,5-arabanase; endo-arabanase; 1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase; arabinan endo-1,5-alpha-L-arabinosidase (misleading) | |
| 3.2.1.100 | mannan 1,4-mannobiosidase | False | 0 | 1 | 0 | 2 | Hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends | 4-beta-D-mannan mannobiohydrolase | None | 1,4-beta-D-mannan mannobiohydrolase; exo-beta-mannanase; exo-1,4-beta-mannobiohydrolase | |
| 3.2.1.101 | mannan endo-1,6-alpha-mannosidase | False | 9 | 6363 | 14 | 1 | Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans | 6-alpha-D-mannan mannanohydrolase | None | endo-alpha-1->6-D-mannanase; endo-1,6-beta-mannanase; mannan endo-1,6-beta-mannosidase; 1,6-alpha-D-mannan mannanohydrolase | |
| 3.2.1.102 | blood-group-substance endo-1,4-beta-galactosidase | False | 1 | 4 | 10 | 5 | Endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances | blood-group-substance 4-beta-D-galactanohydrolase | None | endo-beta-galactosidase (ambiguous); blood-group-substance 1,4-beta-D-galactanohydrolase | |
| 3.2.1.103 | keratan-sulfate endo-1,4-beta-galactosidase | False | 1 | 26 | 0 | 6 | Endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate | keratan-sulfate 4-beta-D-galactanohydrolase | None | endo-beta-galactosidase (ambiguous); keratan sulfate endogalactosidase; keratanase; keratan-sulfate 1,4-beta-D-galactanohydrolase | |
| 3.2.1.104 | steryl-beta-glucosidase | True | 0 | 0 | 0 | 3 | cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol | cholesteryl-beta-D-glucoside glucohydrolase | None | None | |
| 3.2.1.105 | 3alpha(S)-strictosidine beta-glucosidase | False | 1 | 11 | 4 | 12 | strictosidine + H2O = D-glucose + strictosidine aglycone | strictosidine beta-D-glucohydrolase | None | None | |
| 3.2.1.106 | mannosyl-oligosaccharide glucosidase | False | 7 | 6843 | 2 | 22 | Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose | Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting) | None | Glc3Man9NAc2 oligosaccharide glucosidase; trimming glucosidase I; CWH41 (gene name); MOGS (gene name); mannosyl-oligosaccharide glucohydrolase | |
| 3.2.1.107 | protein-glucosylgalactosylhydroxylysine glucosidase | False | 5 | 8 | 0 | 2 | [collagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine + H2O = D-glucose + [collagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine | [collagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine glucohydrolase | None | PGGHG (gene name); 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase; protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase; protein-alpha-D-glucosyl-(1->2)-beta-D-galactosyl-L-hydroxylysine glucohydrolase | |
| 3.2.1.108 | lactase | False | 4 | 30 | 0 | 8 | lactose + H2O = beta-D-galactose + D-glucose | lactose galactohydrolase (configuration-retaining) | None | lactase-phlorizin hydrolase; LPH (gene name); LCT (gene name) | |
| 3.2.1.109 | endogalactosaminidase | False | 0 | 3 | 0 | 2 | Endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine) | galactosaminoglycan glycanohydrolase | None | None | |
| 3.2.1.111 | 1,3-alpha-L-fucosidase | False | 0 | 5 | 4 | 5 | Hydrolysis of (1->3)-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins | 3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase | None | almond emulsin fucosidase I | |
| 3.2.1.112 | 2-deoxyglucosidase | True | 0 | 0 | 0 | 2 | a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol | 2-deoxy-alpha-D-glucoside deoxyglucohydrolase | None | 2-deoxy-alpha-glucosidase; 2-deoxy-alpha-D-glucosidase | |
| 3.2.1.113 | mannosyl-oligosaccharide 1,2-alpha-mannosidase | False | 35 | 295 | 21 | 24 | (1) Man9GlcNAc2-[protein] + 4 H2O = Man5GlcNAc2-[protein] + 4 beta-D-mannopyranose (overall reaction);;(1a) Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,2) + beta-D-mannopyranose;;(1b) Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,2) + H2O = Man7GlcNAc2-[protein] (isomer 7A1,2,3B2) + beta-D-mannopyranose;;(1c) Man7GlcNAc2-[protein] (isomer 7A1,2,3B2) + H2O = Man6GlcNAc2-[protein] (isomer 6A1,2B2) + beta-D-mannopyranose;;(1d) Man6GlcNAc2-[protein] (isomer 6A1,2B2) + H2O = Man5GlcNAc2-[protein] + beta-D-mannopyranose;;(2) Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + 3 H2O = Man5GlcNAc2-[protein] + 3 beta-D-mannopyranose (overall reaction);;(2a) Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + H2O = Man7GlcNAc2-[protein] (isomer 7A1,2,3B1) + beta-D-mannopyranose;;(2b) Man7GlcNAc2-[protein] (isomer 7A1,2,3B1) + H2O = Man6GlcNAc2-[protein] (isomer 6A1,2,3) + beta-D-mannopyranose;;(2c) Man6GlcNAc2-[protein] (isomer 6A1,2,3) + H2O = Man5GlcNAc2-[protein] + beta-D-mannopyranose | Man9GlcNAc2-[protein] alpha-2-mannohydrolase (configuration-inverting) | None | mannosidase 1A; mannosidase 1B; 1,2-alpha-mannosidase; exo-alpha-1,2-mannanase; mannose-9 processing alpha-mannosidase; glycoprotein processing mannosidase I; mannosidase I; Man9-mannosidase; ManI; 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase; MAN1A1 (gene name); MAN1A2 (gene name); MAN1C1 (gene name); 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase | |
| 3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | False | 8 | 40 | 67 | 21 | Man5GlcNAc3-[protein] + 2 H2O = Man3GlcNAc3-[protein] + 2 alpha-D-mannopyranose | (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining) | None | MAN2A1 (gene name); MAN2A2 (gene name); mannosidase II; exo-1,3-1,6-alpha-mannosidase; alpha-D-mannosidase II; alpha-mannosidase II; alpha1-3,6-mannosidase; GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase; Golgi alpha-mannosidase II; ManII; 1,3(1,6)-alpha-D-mannosidase; 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase; (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase | |
| 3.2.1.115 | branched-dextran exo-1,2-alpha-glucosidase | True | 0 | 0 | 0 | 1 | Hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose | (1->2)-alpha-D-glucosyl-branched-dextran 2-glucohydrolase | None | dextran 1,2-alpha-glucosidase; dextran alpha-1,2-debranching enzyme; 1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase | |
| 3.2.1.220 | ipecoside beta-D-glucosidase | True | 0 | 0 | 0 | 0 | (1) ipecoside + H2O = ipecoside aglycone + D-glucopyranose;;(2) N-deacetylipecoside + H2O = N-deacetylipecoside aglycone + D-glucopyranose;;(3) 6-O-methyl-N-deacetylipecoside + H2O = 6-O-methyl-N-deacetylipecoside aglycone + D-glucopyranose | ipecoside glucohydrolase | None | 6-O-methyl-deacetylisoipecoside beta-glucosidase; IpeGlu1 | |
| 3.2.1.116 | glucan 1,4-alpha-maltotriohydrolase | True | 0 | 0 | 0 | 6 | Hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends | 4-alpha-D-glucan maltotriohydrolase | None | exo-maltotriohydrolase; maltotriohydrolase; 1,4-alpha-D-glucan maltotriohydrolase | |
| 3.2.1.117 | amygdalin beta-glucosidase | False | 4 | 3 | 0 | 10 | (R)-amygdalin + H2O = (R)-prunasin + D-glucose | amygdalin beta-D-glucohydrolase | None | amygdalase; amygdalinase; amygdalin hydrolase; amygdalin glucosidase | |
| 3.2.1.118 | prunasin beta-glucosidase | False | 3 | 9 | 0 | 6 | (R)-prunasin + H2O = D-glucose + mandelonitrile | prunasin beta-D-glucohydrolase | None | prunasin hydrolase | |
| 3.2.1.119 | vicianin beta-glucosidase | False | 1 | 3 | 0 | 2 | (R)-vicianin + H2O = mandelonitrile + vicianose | (R)-vicianin beta-D-glucohydrolase | None | vicianin hydrolase | |
| 3.2.1.120 | oligoxyloglucan beta-glycosidase | False | 0 | 2 | 0 | 11 | Hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose [i.e. alpha-xylo-(1->6)-beta-D-glucosyl-] residues from the non-reducing chain ends | oligoxyloglucan xyloglucohydrolase | None | isoprimeverose-producing oligoxyloglucan hydrolase; oligoxyloglucan hydrolase | |
| 3.2.1.121 | polymannuronate hydrolase | True | 0 | 0 | 0 | 1 | Endohydrolysis of the D-mannuronide linkages of polymannuronate | poly(mannuronide) mannuronohydrolase | None | polymannuronic acid polymerase | |
| 3.2.1.122 | maltose-6'-phosphate glucosidase | False | 6 | 527 | 4 | 8 | alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate | alpha-maltose-6'-phosphate 6-phosphoglucohydrolase | None | phospho-alpha-glucosidase; maltose-6'-phosphate 6-phosphoglucohydrolase | |
| 3.2.1.123 | endoglycosylceramidase | False | 3 | 58 | 6 | 16 | oligoglycosylglucosyl-(1<->1)-ceramide + H2O = ceramide + oligoglycosylglucose | oligoglycosylglucosyl-(1<->1)-ceramide glycohydrolase | None | endoglycoceramidase; EGCase; glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase; oligoglycosylglucosylceramide glycohydrolase; oligoglycosylglucosyl(1<->1)ceramide glycohydrolase | |
| 3.2.1.124 | 3-deoxy-2-octulosonidase | True | 0 | 0 | 0 | 4 | Endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides | capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase | None | 2-keto-3-deoxyoctonate hydrolase; octulosylono hydrolase; octulofuranosylono hydrolase; octulopyranosylonohydrolase | |
| 3.2.1.125 | raucaffricine beta-glucosidase | False | 1 | 26 | 8 | 4 | raucaffricine + H2O = D-glucose + vomilenine | raucaffricine beta-D-glucohydrolase | None | raucaffricine beta-D-glucosidase; raucaffricine glucosidase | |
| 3.2.1.126 | coniferin beta-glucosidase | False | 1 | 0 | 0 | 10 | coniferin + H2O = D-glucose + coniferol | coniferin beta-D-glucosidase | None | coniferin-hydrolyzing beta-glucosidase | |
| 3.2.1.127 | 1,6-alpha-L-fucosidase | True | 0 | 0 | 0 | 6 | Hydrolysis of (1->6)-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin | 6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase | None | alpha-L-fucosidase; 1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase | |
| 3.2.1.128 | glycyrrhizin hydrolase | True | 0 | 0 | 0 | 4 | glycyrrhizin + H2O = beta-D-glucuronosyl-(1->2)-D-glucuronate + glycyrrhetinate | glycyrrhizinate glucuronosylhydrolase | None | glycyrrhizinate beta-glucuronidase; glycyrrhizin beta-hydrolase; glycyrrhizinic acid hydrolase | |
| 3.2.1.129 | endo-alpha-sialidase | False | 2 | 29 | 8 | 13 | Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids | polysialoside (2->8)-alpha-sialosylhydrolase | None | endo-N-acylneuraminidase; endoneuraminidase; endo-N-acetylneuraminidase; poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase; poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase; endosialidase; endo-N | |
| 3.2.1.130 | glycoprotein endo-alpha-1,2-mannosidase | False | 5 | 820 | 20 | 11 | GlcMan9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,2) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose | glycoprotein glucosylmannohydrolase (configuration-retaining) | None | glucosylmannosidase; endo-alpha-D-mannosidase; endo-alpha-mannosidase; endomannosidase; glucosyl mannosidase; MANEA (gene name); glycoprotein glucosylmannohydrolase | |
| 3.2.1.131 | xylan alpha-1,2-glucuronosidase | False | 3 | 2213 | 2 | 28 | Hydrolysis of (1->2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans | xylan 2-alpha-D-(4-O-methyl)glucuronohydrolase | None | 1,2-alpha-glucuronidase; alpha-(1->2)-glucuronidase; xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase | |
| 3.2.1.132 | chitosanase | False | 14 | 2582 | 12 | 79 | Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chitosan | chitosan N-acetylglucosaminohydrolase | None | None | |
| 3.2.1.133 | glucan 1,4-alpha-maltohydrolase | False | 3 | 72 | 3 | 18 | hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains | 4-alpha-D-glucan alpha-maltohydrolase | None | maltogenic alpha-amylase; 1,4-alpha-D-glucan alpha-maltohydrolase | |
| 3.2.1.135 | neopullulanase | False | 5 | 1135 | 22 | 22 | Hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose) | pullulan 4-D-glucanohydrolase (panose-forming) | None | pullulanase II | |
| 3.2.1.136 | glucuronoarabinoxylan endo-1,4-beta-xylanase | False | 2 | 162 | 5 | 13 | Endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans | glucuronoarabinoxylan 4-beta-D-xylanohydrolase | None | feraxan endoxylanase; feraxanase; endoarabinoxylanase; glucuronoxylan xylohydrolase; glucuronoxylanase; glucuronoxylan xylanohydrolase; glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase | |
| 3.2.1.137 | mannan exo-1,2-1,6-alpha-mannosidase | True | 0 | 0 | 0 | 2 | Hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in yeast mannan, releasing D-mannose | (1->2)-(1->6)-alpha-D-mannan D-mannohydrolase | None | exo-1,2-1,6-alpha-mannosidase; 1,2-1,6-alpha-D-mannan D-mannohydrolase | |
| 3.2.1.139 | alpha-glucuronidase | False | 12 | 880 | 13 | 34 | an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate | alpha-D-glucosiduronate glucuronohydrolase | None | alpha-glucosiduronase | |
| 3.2.1.140 | lacto-N-biosidase | False | 2 | 2 | 9 | 4 | beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-Gal-(1->3)-D-GlcNAc + beta-D-Gal-(1->4)-D-Glc | oligosaccharide lacto-N-biosylhydrolase | None | None | |
| 3.2.1.141 | 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase | False | 9 | 10447 | 6 | 13 | hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-[(1->4)-alpha-D-glucanosyl]n trehalose to yield trehalose and (1->4)-alpha-D-glucan | 4-alpha-D-[(1->4)-alpha-D-glucano]trehalose glucanohydrolase (trehalose-producing) | None | malto-oligosyltrehalose trehalohydrolase | |
| 3.2.1.142 | limit dextrinase | False | 1 | 3 | 0 | 10 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan | dextrin 6-alpha-glucanohydrolase | None | R-enzyme; amylopectin-1,6-glucosidase; dextrin alpha-1,6-glucanohydrolase | |
| 3.2.1.143 | poly(ADP-ribose) glycohydrolase | False | 16 | 5795 | 45 | 14 | hydrolyses poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D-ribose | None | None | None | |
| 3.2.1.144 | 3-deoxyoctulosonase | True | 0 | 0 | 0 | 1 | 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide | 3-deoxyoctulosonyl-lipopolysaccharide hydrolase | None | alpha-Kdo-ase | |
| 3.2.1.145 | galactan 1,3-beta-galactosidase | False | 0 | 12 | 5 | 10 | Hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans | galactan 3-beta-D-galactosidase | None | galactan (1->3)-beta-D-galactosidase | |
| 3.2.1.146 | beta-galactofuranosidase | True | 0 | 0 | 0 | 29 | Hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose | beta-D-galactofuranoside hydrolase | None | exo-beta-galactofuranosidase; exo-beta-D-galactofuranosidase; beta-D-galactofuranosidase | |
| 3.2.1.147 | thioglucosidase | False | 13 | 1259 | 12 | 53 | a thioglucoside + H2O = a sugar + a thiol | thioglucoside glucohydrolase | None | myrosinase; sinigrinase; sinigrase | |
| 3.2.1.149 | beta-primeverosidase | False | 0 | 7 | 3 | 4 | a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol | 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase | None | None | |
| 3.2.1.150 | oligoxyloglucan reducing-end-specific cellobiohydrolase | False | 3 | 0 | 2 | 2 | Hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a (1->4)-beta-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted. | oligoxyloglucan reducing-end cellobiohydrolase | None | None | |
| 3.2.1.151 | xyloglucan-specific endo-beta-1,4-glucanase | False | 17 | 555 | 26 | 55 | xyloglucan + H2O = xyloglucan oligosaccharides | [(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase | None | XEG; xyloglucan endo-beta-1,4-glucanase; xyloglucanase; xyloglucanendohydrolase; XH; 1,4-beta-D-glucan glucanohydrolase | |
| 3.2.1.152 | mannosylglycoprotein endo-beta-mannosidase | False | 2 | 36 | 0 | 3 | Hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequences | None | None | endo-beta-mannosidase | |
| 3.2.1.153 | fructan beta-(2,1)-fructosidase | False | 9 | 66 | 4 | 10 | Hydrolysis of terminal, non-reducing (2->1)-linked beta-D-fructofuranose residues in fructans | beta-(2->1)-D-fructan fructohydrolase | None | beta-(2-1)-D-fructan fructohydrolase; beta-(2-1)fructan exohydrolase; inulinase; 1-FEH II; 1-fructan exohydrolase; 1-FEH w1; 1-FEH w2; beta-(2-1)-linkage-specific fructan-beta-fructosidase; beta-(2,1)-D-fructan fructohydrolase | |
| 3.2.1.154 | fructan beta-(2,6)-fructosidase | False | 2 | 1 | 0 | 13 | Hydrolysis of terminal, non-reducing (2->6)-linked beta-D-fructofuranose residues in fructans | (2->6)-beta-D-fructan fructohydrolase | None | beta-(2-6)-fructan exohydrolase; levanase; 6-FEH; beta-(2,6)-D-fructan fructohydrolase | |
| 3.2.1.156 | oligosaccharide reducing-end xylanase | False | 3 | 107 | 15 | 6 | Hydrolysis of (1->4)-beta-D-xylose residues from the reducing end of oligosaccharides | beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase | None | Rex; reducing end xylose-releasing exo-oligoxylanase | |
| 3.2.2.1 | purine nucleosidase | False | 3 | 1288 | 27 | 41 | a purine nucleoside + H2O = D-ribose + a purine base | purine-nucleoside ribohydrolase | None | nucleosidase (misleading); purine beta-ribosidase; purine nucleoside hydrolase; purine ribonucleosidase; ribonucleoside hydrolase (misleading); nucleoside hydrolase (misleading); N-ribosyl purine ribohydrolase; nucleosidase g; N-D-ribosylpurine ribohydrolase; inosine-adenosine-guanosine preferring nucleoside hydrolase; purine-specific nucleoside N-ribohydrolase; IAG-nucleoside hydrolase; IAG-NH | |
| 3.2.2.2 | inosine nucleosidase | False | 6 | 12 | 0 | 9 | inosine + H2O = D-ribose + hypoxanthine | inosine ribohydrolase | None | inosinase; inosine-guanosine nucleosidase | |
| 3.2.2.3 | uridine nucleosidase | False | 8 | 297 | 27 | 13 | uridine + H2O = D-ribose + uracil | uridine ribohydrolase | None | uridine hydrolase | |
| 3.2.2.4 | AMP nucleosidase | False | 7 | 17843 | 6 | 3 | AMP + H2O = D-ribose 5-phosphate + adenine | AMP phosphoribohydrolase | None | adenylate nucleosidase; adenosine monophosphate nucleosidase | |
| 3.2.2.5 | NAD+ glycohydrolase | False | 24 | 727 | 77 | 27 | NAD+ + H2O = ADP-D-ribose + nicotinamide | NAD+ glycohydrolase | None | NAD glycohydrolase; nicotinamide adenine dinucleotide glycohydrolase; beta-NAD+ glycohydrolase; DPNase (ambiguous); NAD hydrolase (ambiguous); diphosphopyridine nucleosidase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD nucleosidase (ambiguous); DPN hydrolase (ambiguous); NADase (ambiguous); nga (gene name); NAD+ nucleosidase | |
| 3.2.2.6 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | False | 96 | 7876 | 63 | 11 | NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction);;(1a) NAD+ = cyclic ADP-ribose + nicotinamide;;(1b) cyclic ADP-ribose + H2O = ADP-D-ribose | NAD+ glycohydrolase (cyclic ADP-ribose-forming) | None | NAD+ nucleosidase; NADase (ambiguous); DPNase (ambiguous); DPN hydrolase (ambiguous); NAD hydrolase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD glycohydrolase (misleading); NAD nucleosidase (ambiguous); nicotinamide adenine dinucleotide glycohydrolase (misleading); CD38 (gene name); BST1 (gene name) | |
| 3.2.2.7 | adenosine nucleosidase | False | 3 | 0 | 0 | 27 | adenosine + H2O = D-ribose + adenine | adenosine ribohydrolase | None | adenosinase; N-ribosyladenine ribohydrolase; adenosine hydrolase; ANase | |
| 3.2.2.8 | ribosylpyrimidine nucleosidase | False | 29 | 730 | 6 | 9 | a pyrimidine nucleoside + H2O = D-ribose + a pyrimidine base | pyrimidine-nucleoside ribohydrolase | None | N-ribosylpyrimidine nucleosidase; pyrimidine nucleosidase; N-ribosylpyrimidine ribohydrolase; pyrimidine nucleoside hydrolase; RihB; YeiK; nucleoside ribohydrolase | |
| 3.2.2.9 | adenosylhomocysteine nucleosidase | False | 194 | 14818 | 51 | 24 | (1) S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine;;(2) 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine;;(3) S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine | S-adenosyl-L-homocysteine homocysteinylribohydrolase | None | S-adenosylhomocysteine hydrolase (ambiguous); S-adenosylhomocysteine nucleosidase; 5'-methyladenosine nucleosidase; S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase; AdoHcy/MTA nucleosidase; MTN2 (gene name); mtnN (gene name) | |
| 3.2.2.10 | pyrimidine-5'-nucleotide nucleosidase | False | 4 | 47 | 4 | 6 | a pyrimidine 5'-nucleotide + H2O = D-ribose 5-phosphate + a pyrimidine base | pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase | None | pyrimidine nucleotide N-ribosidase; Pyr5N | |
| 3.2.2.11 | beta-aspartyl-N-acetylglucosaminidase | True | 0 | 0 | 0 | 4 | 1-beta-aspartyl-N-acetyl-D-glucosaminylamine + H2O = L-asparagine + N-acetyl-D-glucosamine | 1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase | None | beta-aspartylacetylglucosaminidase | |
| 3.2.2.12 | inosinate nucleosidase | True | 0 | 0 | 0 | 1 | IMP + H2O = D-ribose 5-phosphate + hypoxanthine | IMP phosphoribohydrolase | None | 5'-inosinate phosphoribohydrolase | |
| 3.2.2.13 | 1-methyladenosine nucleosidase | True | 0 | 0 | 0 | 2 | 1-methyladenosine + H2O = 1-methyladenine + D-ribose | 1-methyladenosine ribohydrolase | None | 1-methyladenosine hydrolase | |
| 3.2.2.14 | NMN nucleosidase | False | 0 | 1 | 0 | 6 | beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide | nicotinamide-nucleotide phosphoribohydrolase | None | NMNase; nicotinamide mononucleotide nucleosidase; nicotinamide mononucleotidase; NMN glycohydrolase; NMNGhase | |
| 3.2.2.15 | DNA-deoxyinosine glycosylase | False | 0 | 2789 | 0 | 7 | Hydrolyses DNA and polynucleotides, releasing free hypoxanthine | DNA-deoxyinosine deoxyribohydrolase | None | DNA(hypoxanthine) glycohydrolase; deoxyribonucleic acid glycosylase; hypoxanthine-DNA glycosylase | |
| 3.2.2.16 | methylthioadenosine nucleosidase | False | 1 | 303 | 19 | 24 | S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine | S-methyl-5'-thioadenosine adeninehyrolase | None | 5'-methylthioadenosine nucleosidase; MTA nucleosidase; MeSAdo nucleosidase; methylthioadenosine methylthioribohydrolase; MTN1 (gene name) | |
| 3.2.2.17 | deoxyribodipyrimidine endonucleosidase | False | 1 | 30 | 2 | 5 | Cleaves the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue | deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase | None | pyrimidine dimer DNA-glycosylase; endonuclease V; deoxyribonucleate pyrimidine dimer glycosidase; pyrimidine dimer DNA glycosylase; T4-induced UV endonuclease; PD-DNA glycosylase | |
| 3.2.2.19 | [protein ADP-ribosylarginine] hydrolase | False | 8 | 77 | 4 | 12 | (1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine;;(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine | protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase | None | ADP-ribose-L-arginine cleavage enzyme; ADP-ribosylarginine hydrolase; Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase; protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase | |
| 3.2.2.20 | DNA-3-methyladenine glycosylase I | False | 2 | 5659 | 9 | 15 | Hydrolysis of alkylated DNA, releasing 3-methyladenine | alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) | None | deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I | |
| 3.2.2.21 | DNA-3-methyladenine glycosylase II | False | 12 | 28559 | 29 | 11 | Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine | alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) | None | deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA | |
| 3.2.2.22 | rRNA N-glycosylase | False | 88 | 2273 | 266 | 66 | Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes | rRNA N-glycohydrolase | None | ribosomal ribonucleate N-glycosidase; nigrin b; RNA N-glycosidase; rRNA N-glycosidase; ricin; momorcochin-S; Mirabilis antiviral protein; momorcochin-S; gelonin; saporins | |
| 3.2.2.23 | DNA-formamidopyrimidine glycosylase | False | 453 | 26760 | 54 | 13 | Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] | None | Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein | |
| 3.2.2.24 | ADP-ribosyl-[dinitrogen reductase] hydrolase | False | 1 | 999 | 7 | 5 | [dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + [dinitrogen reductase]-L-arginine | ADP-D-ribosyl-[dinitrogen reductase] ADP-ribosylhydrolase | None | azoferredoxin glycosidase; azoferredoxin-activating enzymes; dinitrogenase reductase-activating glycohydrolase; ADP-ribosyl glycohydrolase; draG (gene name) | |
| 3.3.2.1 | isochorismatase | False | 10 | 3584 | 6 | 14 | isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate | isochorismate pyruvate-hydrolase | None | 2,3-dihydro-2,3-dihydroxybenzoate synthase; 2,3-dihydroxy-2,3-dihydrobenzoate synthase; 2,3-dihydroxy-2,3-dihydrobenzoic synthase | |
| 3.3.2.2 | lysoplasmalogenase | False | 12 | 1983 | 0 | 4 | (1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine;;(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine | lysoplasmalogen aldehydohydrolase | None | alkenylglycerophosphocholine hydrolase; alkenylglycerophosphoethanolamine hydrolase; 1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase | |
| 3.3.2.4 | trans-epoxysuccinate hydrolase | True | 0 | 0 | 0 | 2 | trans-2,3-epoxysuccinate + H2O = meso-tartrate | trans-2,3-epoxysuccinate hydrolase | None | trans-epoxysuccinate hydratase; tartrate epoxydase | |
| 3.3.2.6 | leukotriene-A4 hydrolase | False | 8 | 1088 | 80 | 11 | leukotriene A4 + H2O = leukotriene B4 | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase | None | LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase | |
| 1.14.14.10 | nitrilotriacetate monooxygenase | False | 1 | 761 | 0 | 6 | nitrilotriacetate + FMNH2 + H+ + O2 = iminodiacetate + glyoxylate + FMN + H2O | nitrilotriacetate,FMNH2:oxygen oxidoreductase (glyoxylate-forming) | None | None | |
| 3.3.2.7 | hepoxilin-epoxide hydrolase | True | 0 | 0 | 0 | 2 | hepoxilin A3 + H2O = trioxilin A3 | (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase | None | hepoxilin epoxide hydrolase; hepoxylin hydrolase; hepoxilin A3 hydrolase | |
| 3.3.2.8 | limonene-1,2-epoxide hydrolase | False | 1 | 149 | 27 | 3 | 1,2-epoxymenth-8-ene + H2O = menth-8-ene-1,2-diol | 1,2-epoxymenth-8-ene hydrolase | None | limonene oxide hydrolase | |
| 3.5.1.1 | asparaginase | False | 46 | 19993 | 119 | 123 | L-asparagine + H2O = L-aspartate + NH3 | L-asparagine amidohydrolase | None | asparaginase II; L-asparaginase; colaspase; elspar; leunase; crasnitin; alpha-asparaginase | |
| 3.5.1.2 | glutaminase | False | 905 | 99482 | 65 | 49 | L-glutamine + H2O = L-glutamate + NH3 | L-glutamine amidohydrolase | None | glutaminase I; L-glutaminase; glutamine aminohydrolase | |
| 3.5.1.3 | omega-amidase | False | 15 | 2066 | 0 | 20 | a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3 | omega-amidodicarboxylate amidohydrolase | None | alpha-keto acid-omega-amidase | |
| 3.5.1.4 | amidase | False | 64 | 25229 | 34 | 54 | a monocarboxylic acid amide + H2O = a monocarboxylate + NH3 | acylamide amidohydrolase | None | acylamidase; acylase (misleading); amidohydrolase (ambiguous); deaminase (ambiguous); fatty acylamidase; N-acetylaminohydrolase (ambiguous) | |
| 3.5.1.5 | urease | False | 827 | 50656 | 84 | 68 | urea + H2O = CO2 + 2 NH3 | urea amidohydrolase | None | None | |
| 3.5.1.6 | beta-ureidopropionase | False | 6 | 345 | 15 | 28 | 3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3 | 3-ureidopropanoate amidohydrolase | None | N-carbamoyl-beta-alanine amidohydrolase | |
| 3.5.1.7 | ureidosuccinase | True | 0 | 0 | 0 | 1 | N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3 | N-carbamoyl-L-aspartate amidohydrolase | None | None | |
| 3.5.1.8 | formylaspartate deformylase | False | 0 | 1 | 0 | 1 | N-formyl-L-aspartate + H2O = formate + L-aspartate | N-formyl-L-aspartate amidohydrolase | None | formylaspartic formylase (formylase I, formylase II) | |
| 3.5.1.9 | arylformamidase | False | 66 | 5200 | 8 | 33 | N-formyl-L-kynurenine + H2O = formate + L-kynurenine | aryl-formylamine amidohydrolase | None | kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II | |
| 3.5.1.10 | formyltetrahydrofolate deformylase | False | 12 | 23520 | 3 | 4 | 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate | 10-formyltetrahydrofolate amidohydrolase | None | None | |
| 3.5.1.11 | penicillin amidase | False | 8 | 1274 | 43 | 29 | penicillin + H2O = a carboxylate + 6-aminopenicillanate | penicillin amidohydrolase | None | penicillin acylase; benzylpenicillin acylase; novozym 217; semacylase; alpha-acylamino-beta-lactam acylhydrolase; ampicillin acylase | |
| 3.5.1.12 | biotinidase | False | 5 | 1148 | 0 | 10 | biocytin + H2O = biotin + L-lysine | biocytin amidohydrolase | None | amidohydrolase biotinidase; biocytinase; biotin-amide amidohydrolase | |
| 3.5.1.13 | aryl-acylamidase | False | 2 | 497 | 2 | 51 | an anilide + H2O = a carboxylate + aniline | aryl-acylamide amidohydrolase | None | AAA-1; AAA-2; brain acetylcholinesterase (is associated with AAA-2); pseudocholinesterase (associated with arylacylamidase) | |
| 3.5.1.14 | N-acyl-aliphatic-L-amino acid amidohydrolase | False | 17 | 4221 | 3 | 28 | (1) an N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate;;(2) an N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate | N-acyl-aliphatic-L-amino acid amidohydrolase (carboxylate-forming) | None | aminoacylase 1; aminoacylase I; dehydropeptidase II; histozyme; hippuricase; benzamidase; acylase I; hippurase; amido acid deacylase; L-aminoacylase; acylase; aminoacylase; L-amino-acid acylase; alpha-N-acylaminoacid hydrolase; long acyl amidoacylase; short acyl amidoacylase; ACY1 (gene name); N-acyl-L-amino-acid amidohydrolase | |
| 3.5.1.15 | aspartoacylase | False | 27 | 1266 | 10 | 15 | N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate | N-acyl-L-aspartate amidohydrolase | None | aminoacylase II; N-acetylaspartate amidohydrolase; acetyl-aspartic deaminase; acylase II | |
| 3.5.1.16 | acetylornithine deacetylase | False | 73 | 5648 | 7 | 15 | N2-acetyl-L-ornithine + H2O = acetate + L-ornithine | N2-acetyl-L-ornithine amidohydrolase | None | acetylornithinase; N-acetylornithinase; 2-N-acetyl-L-ornithine amidohydrolase | |
| 3.5.1.17 | acyl-lysine deacylase | False | 0 | 0 | 2 | 9 | N6-acyl-L-lysine + H2O = a carboxylate + L-lysine | N6-acyl-L-lysine amidohydrolase | None | epsilon-lysine acylase; 6-N-acyl-L-lysine amidohydrolase | |
| 3.5.1.18 | succinyl-diaminopimelate desuccinylase | False | 395 | 36320 | 16 | 15 | N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate | N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase | None | N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase | |
| 3.5.1.19 | nicotinamidase | False | 8 | 19552 | 9 | 36 | nicotinamide + H2O = nicotinate + NH3 | nicotinamide amidohydrolase | None | nicotinamide deaminase; nicotinamide amidase; YNDase | |
| 3.5.1.20 | citrullinase | False | 1 | 0 | 0 | 8 | L-citrulline + H2O = L-ornithine + CO2 + NH3 | L-citrulline N5-carbamoyldihydrolase | None | citrulline ureidase; citrulline hydrolase; L-citrulline 5-N-carbamoyldihydrolase | |
| 3.5.1.21 | N-acetyl-beta-alanine deacetylase | True | 0 | 0 | 0 | 2 | N-acetyl-beta-alanine + H2O = acetate + beta-alanine | N-acetyl-beta-alanine amidohydrolase | None | None | |
| 3.5.1.22 | pantothenase | True | 0 | 0 | 0 | 3 | (R)-pantothenate + H2O = (R)-pantoate + beta-alanine | (R)-pantothenate amidohydrolase | None | pantothenate hydrolase; pantothenate amidohydrolase | |
| 3.5.1.23 | ceramidase | False | 40 | 10312 | 6 | 23 | a ceramide + H2O = a carboxylate + sphingosine | N-acylsphingosine amidohydrolase | None | acylsphingosine deacylase; glycosphingolipid ceramide deacylase | |
| 3.5.1.24 | choloylglycine hydrolase | False | 6 | 2675 | 17 | 47 | glycocholate + H2O = cholate + glycine | glycocholate amidohydrolase | None | glycocholase; bile salt hydrolase; choloyltaurine hydrolase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase | |
| 3.5.1.25 | N-acetylglucosamine-6-phosphate deacetylase | False | 15 | 19876 | 12 | 18 | N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate | N-acetyl-D-glucosamine-6-phosphate amidohydrolase | None | acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase | |
| 3.5.1.26 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase | False | 17 | 383 | 14 | 13 | N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate | N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase | None | aspartylglucosylamine deaspartylase; aspartylglucosylaminase; aspartylglucosaminidase; aspartylglycosylamine amidohydrolase; N-aspartyl-beta-glucosaminidase; glucosylamidase; beta-aspartylglucosylamine amidohydrolase; 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase | |
| 3.5.1.28 | N-acetylmuramoyl-L-alanine amidase | False | 90 | 74532 | 56 | 45 | Hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides | peptidoglycan amidohydrolase | None | acetylmuramyl-L-alanine amidase; N-acetylmuramyl-L-alanine amidase; N-acylmuramyl-L-alanine amidase; acetylmuramoyl-alanine amidase; N-acetylmuramic acid L-alanine amidase; acetylmuramyl-alanine amidase; N-acetylmuramylalanine amidase; murein hydrolase; N-acetylmuramoyl-L-alanine amidase type I; N-acetylmuramoyl-L-alanine amidase type II | |
| 3.5.1.29 | 2-(acetamidomethylene)succinate hydrolase | False | 1 | 176 | 0 | 4 | 2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2 | 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating) | None | alpha-(N-acetylaminomethylene)succinic acid hydrolase | |
| 3.5.1.30 | 5-aminopentanamidase | False | 0 | 58 | 0 | 1 | 5-aminopentanamide + H2O = 5-aminopentanoate + NH3 | 5-aminopentanamide amidohydrolase | None | 5-aminovaleramidase; 5-aminonorvaleramidase | |
| 3.5.1.31 | formylmethionine deformylase | False | 0 | 30 | 16 | 6 | N-formyl-L-methionine + H2O = formate + L-methionine | N-formyl-L-methionine amidohydrolase | None | None | |
| 3.5.1.32 | hippurate hydrolase | False | 1 | 2218 | 0 | 27 | hippurate + H2O = benzoate + glycine | N-benzoylamino-acid amidohydrolase | None | None | |
| 3.5.1.33 | N-acetylglucosamine deacetylase | False | 0 | 2 | 4 | 12 | N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate | N-acetyl-D-glucosamine amidohydrolase | None | acetylaminodeoxyglucose acetylhydrolase; N-acetyl-D-glucosaminyl N-deacetylase | |
| 3.5.1.35 | D-glutaminase | True | 0 | 0 | 0 | 1 | D-glutamine + H2O = D-glutamate + NH3 | D-glutamine amidohydrolase | None | None | |
| 3.5.1.36 | N-methyl-2-oxoglutaramate hydrolase | True | 0 | 0 | 0 | 1 | N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine | N-methyl-2-oxoglutaramate methylamidohydrolase | None | 5-hydroxy-N-methylpyroglutamate synthase | |
| 3.5.1.38 | glutamin-(asparagin-)ase | False | 6 | 242 | 10 | 14 | (1) L-glutamine + H2O = L-glutamate + NH3;;(2) L-asparagine + H2O = L-aspartate + NH3 | L-glutamine(L-asparagine) amidohydrolase | None | glutaminase-asparaginase; ansB (gene name); L-asparagine/L-glutamine amidohydrolase; L-ASNase/L-GLNase | |
| 3.5.1.39 | alkylamidase | True | 0 | 0 | 0 | 1 | N-methylhexanamide + H2O = hexanoate + methylamine | N-methylhexanamide amidohydrolase | None | None | |
| 3.5.1.40 | acylagmatine amidase | True | 0 | 0 | 0 | 1 | benzoylagmatine + H2O = benzoate + agmatine | benzoylagmatine amidohydrolase | None | acylagmatine amidohydrolase; acylagmatine deacylase | |
| 3.5.1.41 | chitin deacetylase | False | 16 | 3032 | 18 | 64 | chitin + H2O = chitosan + acetate | chitin amidohydrolase | None | None | |
| 3.5.1.42 | nicotinamide-nucleotide amidase | False | 6 | 789 | 0 | 21 | beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3 | nicotinamide-D-ribonucleotide amidohydrolase | None | NMN deamidase; nicotinamide mononucleotide deamidase; nicotinamide mononucleotide amidohydrolase | |
| 3.5.1.43 | peptidyl-glutaminase | True | 0 | 0 | 0 | 1 | alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3 | peptidyl-L-glutamine amidohydrolase | None | peptidoglutaminase I; peptideglutaminase; peptidoglutaminase | |
| 3.5.1.44 | protein-glutamine glutaminase | False | 406 | 36784 | 1 | 3 | protein L-glutamine + H2O = protein L-glutamate + NH3 | protein-L-glutamine amidohydrolase | None | peptidoglutaminase II; glutaminyl-peptide glutaminase; destabilase; peptidylglutaminase II | |
| 3.5.1.46 | 6-aminohexanoate-oligomer exohydrolase | False | 2 | 958 | 19 | 6 | (1) [N-(6-aminohexanoyl)]n + H2O = [N-(6-aminohexanoyl)]n-1 + 6-aminohexanoate;;(2) N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate | N-(6-aminohexanoyl)-6-aminohexanoate exoamidohydrolase | None | 6-aminohexanoate-dimer hydrolase; nylB (gene name); 6-aminohexanoic acid oligomer hydrolase (ambiguous); N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase; nylon-6 hydrolase (ambiguous) | |
| 3.5.1.47 | N-acetyldiaminopimelate deacetylase | False | 74 | 2612 | 0 | 6 | N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate | N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase | None | N-acetyl-L-diaminopimelic acid deacylase; N-acetyl-LL-diaminopimelate deacylase; 6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase | |
| 3.5.1.48 | acetylspermidine deacetylase | False | 5 | 96 | 27 | 5 | N8-acetylspermidine + H2O = acetate + spermidine | N8-acetylspermidine amidohydrolase | None | N8-monoacetylspermidine deacetylase; N8-acetylspermidine deacetylase; N-acetylspermidine deacetylase; N1-acetylspermidine amidohydrolase (incorrect); 8-N-acetylspermidine amidohydrolase | |
| 3.5.1.49 | formamidase | False | 29 | 1981 | 6 | 11 | formamide + H2O = formate + NH3 | formamide amidohydrolase | None | None | |
| 3.5.1.50 | pentanamidase | True | 0 | 0 | 0 | 1 | pentanamide + H2O = pentanoate + NH3 | pentanamide amidohydrolase | None | valeramidase | |
| 3.5.1.51 | 4-acetamidobutyryl-CoA deacetylase | False | 0 | 1 | 0 | 1 | 4-acetamidobutanoyl-CoA + H2O = acetate + 4-aminobutanoyl-CoA | 4-acetamidobutanoyl-CoA amidohydrolase | None | aminobutyryl-CoA thiolesterase; deacetylase-thiolesterase | |
| 3.5.1.52 | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase | False | 22 | 1746 | 15 | 26 | Hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue | N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase | None | glycopeptide N-glycosidase; glycopeptidase; N-oligosaccharide glycopeptidase; N-glycanase; Jack-bean glycopeptidase; PNGase A; PNGase F | |
| 3.5.1.53 | N-carbamoylputrescine amidase | False | 4 | 2330 | 1 | 7 | N-carbamoylputrescine + H2O = putrescine + CO2 + NH3 | N-carbamoylputrescine amidohydrolase | None | carbamoylputrescine hydrolase; NCP | |
| 3.5.1.54 | allophanate hydrolase | False | 3 | 3442 | 6 | 13 | urea-1-carboxylate + H2O = 2 CO2 + 2 NH3 | urea-1-carboxylate amidohydrolase | None | allophanate lyase; AtzF; TrzF | |
| 3.5.1.55 | long-chain-fatty-acyl-glutamate deacylase | True | 0 | 0 | 0 | 2 | N-long-chain-fatty-acyl-L-glutamate + H2O = a long-chain carboxylate + L-glutamate | N-long-chain-fatty-acyl-L-glutamate amidohydrolase | None | long-chain aminoacylase; long-chain-fatty-acyl-glutamate deacylase; long-chain acylglutamate amidase; N-acyl-D-glutamate deacylase | |
| 3.5.1.56 | N,N-dimethylformamidase | False | 4 | 148 | 6 | 5 | N,N-dimethylformamide + H2O = dimethylamine + formate | N,N-dimethylformamide amidohydrolase | None | dimethylformamidase; DMFase | |
| 3.5.1.57 | tryptophanamidase | True | 0 | 0 | 0 | 2 | L-tryptophanamide + H2O = L-tryptophan + NH3 | L-tryptophanamide amidohydrolase | None | tryptophan aminopeptidase; L-tryptophan aminopeptidase | |
| 3.5.1.58 | N-benzyloxycarbonylglycine hydrolase | True | 0 | 0 | 0 | 1 | N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine | N-benzyloxycarbonylglycine urethanehydrolase | None | benzyloxycarbonylglycine hydrolase; Nalpha-carbobenzoxyamino acid amidohydrolase; Nalpha-benzyloxycarbonyl amino acid urethane hydrolase; Nalpha-benzyloxycarbonyl amino acid urethane hydrolase I | |
| 3.5.1.59 | N-carbamoylsarcosine amidase | False | 1 | 257 | 2 | 6 | N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3 | N-carbamoylsarcosine amidohydrolase | None | carbamoylsarcosine amidase | |
| 3.5.1.60 | N-(long-chain-acyl)ethanolamine deacylase | False | 6 | 659 | 8 | 6 | N-(long-chain-acyl)ethanolamine + H2O = a long-chain carboxylate + ethanolamine | N-(long-chain-acyl)ethanolamine amidohydrolase | None | NAAA (gene name); N-acylethanolamine amidohydrolase; acylethanolamine amidase | |
| 3.5.1.62 | acetylputrescine deacetylase | False | 8 | 4 | 0 | 3 | N-acetylputrescine + H2O = acetate + putrescine | N-acetylputrescine acetylhydrolase | None | None | |
| 3.5.1.63 | 4-acetamidobutyrate deacetylase | True | 0 | 0 | 0 | 4 | 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate | 4-acetamidobutanoate amidohydrolase | None | None | |
| 3.5.1.64 | Nalpha-benzyloxycarbonylleucine hydrolase | True | 0 | 0 | 0 | 1 | Nalpha-benzyloxycarbonyl-L-leucine + H2O = benzyl alcohol + CO2 + L-leucine | Nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase | None | benzyloxycarbonylleucine hydrolase; Nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV; alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase | |
| 3.5.1.65 | theanine hydrolase | True | 0 | 0 | 0 | 4 | N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine | N5-ethyl-L-glutamine amidohydrolase | None | L-theanine amidohydrolase; 5-N-ethyl-L-glutamine amidohydrolase | |
| 3.5.1.66 | 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase | True | 0 | 0 | 0 | 2 | 2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O = acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2 | 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating) | None | compound B hydrolase; alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase | |
| 3.5.1.67 | 4-methyleneglutaminase | True | 0 | 0 | 0 | 1 | 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3 | 4-methylene-L-glutamine amidohydrolase | None | 4-methyleneglutamine deamidase; 4-methyleneglutamine amidohydrolase | |
| 3.5.1.68 | N-formylglutamate deformylase | False | 2 | 2551 | 0 | 3 | N-formyl-L-glutamate + H2O = formate + L-glutamate | N-formyl-L-glutamate amidohydrolase | None | beta-citryl-L-glutamate hydrolase; formylglutamate deformylase; N-formylglutamate hydrolase; beta-citrylglutamate amidase; beta-citryl-L-glutamate amidohydrolase; beta-citryl-L-glutamate amidase; beta-citryl-L-glutamate-hydrolyzing enzyme | |
| 3.5.1.69 | glycosphingolipid deacylase | False | 0 | 2 | 0 | 3 | Hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives | glycosphingolipid amidohydrolase | None | glycosphingolipid ceramide deacylase | |
| 3.5.1.70 | aculeacin-A deacylase | True | 0 | 0 | 0 | 1 | Hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain | aculeacin-A amidohydrolase | None | aculeacin A acylase | |
| 3.5.1.71 | N-feruloylglycine deacylase | True | 0 | 0 | 0 | 6 | N-feruloylglycine + H2O = ferulate + glycine | N-feruloylglycine amidohydrolase | None | N-feruloylglycine hydrolase | |
| 3.5.1.72 | D-benzoylarginine-4-nitroanilide amidase | True | 0 | 0 | 0 | 10 | N-benzoyl-D-arginine-4-nitroanilide + H2O = N-benzoyl-D-arginine + 4-nitroaniline | N-benzoyl-D-arginine-4-nitroanilide amidohydrolase | None | benzoyl-D-arginine arylamidase; D-BAPA-ase | |
| 3.5.1.73 | carnitinamidase | True | 0 | 0 | 0 | 1 | L-carnitinamide + H2O = L-carnitine + NH3 | L-carnitinamide amidohydrolase | None | L-carnitinamidase; carnitine amidase; L-carnitine amidase | |
| 3.5.1.74 | chenodeoxycholoyltaurine hydrolase | False | 4 | 0 | 0 | 1 | chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine | chenodeoxycholoyltaurine amidohydrolase | None | None | |
| 3.5.1.75 | urethanase | False | 0 | 2 | 1 | 10 | urethane + H2O = ethanol + CO2 + NH3 | urethane amidohydrolase (decarboxylating) | None | urethane hydrolase | |
| 3.5.1.76 | arylalkyl acylamidase | False | 1 | 0 | 0 | 1 | N-acetylarylalkylamine + H2O = arylalkylamine + acetate | N-acetylarylalkylamine amidohydrolase | None | aralkyl acylamidase | |
| 3.5.1.77 | N-carbamoyl-D-amino-acid hydrolase | False | 3 | 1095 | 8 | 12 | an N-carbamoyl-D-amino acid + H2O = a D-amino acid + NH3 + CO2 | N-carbamoyl-D-amino-acid amidohydrolase | None | D-N-carbamoylase; N-carbamoylase (ambiguous); N-carbamoyl-D-amino acid hydrolase | |
| 3.5.1.78 | glutathionylspermidine amidase | False | 2 | 282 | 0 | 3 | glutathionylspermidine + H2O = glutathione + spermidine | gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase | None | glutathionylspermidine amidohydrolase (spermidine-forming) | |
| 3.5.1.79 | phthalyl amidase | False | 1 | 31 | 0 | 1 | a phthalylamide + H2O = phthalic acid + a substituted amine | phthalyl-amide amidohydrolase | None | None | |
| 3.5.1.81 | N-acyl-D-amino-acid deacylase | False | 1 | 1247 | 8 | 13 | N-acyl-D-amino acid + H2O = a carboxylate + D-amino acid | N-acyl-D-amino acid amidohydrolase | None | None | |
| 3.5.1.82 | N-acyl-D-glutamate deacylase | False | 1 | 402 | 2 | 2 | N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate | N-acyl-D-glutamate amidohydrolase | None | None | |
| 3.5.1.83 | N-acyl-D-aspartate deacylase | False | 1 | 131 | 0 | 1 | N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate | N-acyl-D-aspartate amidohydrolase | None | None | |
| 3.5.1.84 | biuret amidohydrolase | False | 1 | 156 | 2 | 7 | biuret + H2O = urea-1-carboxylate + NH3 | biuret amidohydrolase | None | biuH (gene name) | |
| 3.5.1.130 | [amino group carrier protein]-lysine hydrolase | False | 18 | 1384 | 0 | 1 | [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine | [amino group carrier protein]-C-terminal-gamma-L-lysyl-L-glutamate amidohydrolase | None | lysK (gene name) | |
| 3.5.1.85 | (S)-N-acetyl-1-phenylethylamine hydrolase | True | 0 | 0 | 0 | 1 | N-acetylphenylethylamine + H2O = phenylethylamine + acetate | (S)-N-acetylphenylethylamine:H2O hydrolase | None | None | |
| 3.5.1.86 | mandelamide amidase | False | 1 | 258 | 0 | 8 | (R)-mandelamide + H2O = (R)-mandelate + NH3 | mandelamide hydrolase | None | Pseudomonas mandelamide hydrolase | |
| 3.5.1.87 | N-carbamoyl-L-amino-acid hydrolase | False | 5 | 2403 | 8 | 9 | an N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = an L-2-amino acid + NH3 + CO2 | N-carbamoyl-L-amino-acid amidohydrolase | None | N-carbamyl L-amino acid amidohydrolase; N-carbamoyl-L-amino acid amidohydrolase; L-N-carbamoylase; N-carbamoylase (ambiguous) | |
| 3.5.1.88 | peptide deformylase | False | 472 | 63827 | 149 | 50 | formyl-L-methionyl peptide + H2O = formate + methionyl peptide | formyl-L-methionyl peptide amidohydrolase | None | N-formylmethionylaminoacyl-tRNA deformylase | |
| 3.5.1.89 | N-acetylglucosaminylphosphatidylinositol deacetylase | False | 8 | 4979 | 0 | 7 | 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate | 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase | None | N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase; N-acetylglucosaminylphosphatidylinositol de-N-acetylase; GlcNAc-PI de-N-acetylase; GlcNAc-PI deacetylase; acetylglucosaminylphosphatidylinositol deacetylase | |
| 3.5.1.90 | adenosylcobinamide hydrolase | False | 2 | 153 | 0 | 12 | adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol | adenosylcobinamide amidohydrolase | None | CbiZ; AdoCbi amidohydrolase | |
| 3.5.1.91 | N-substituted formamide deformylase | False | 1 | 1772 | 0 | 1 | N-benzylformamide + H2O = formate + benzylamine | N-benzylformamide amidohydrolase | None | NfdA | |
| 3.5.1.92 | pantetheine hydrolase | False | 6 | 248 | 8 | 6 | (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol | (R)-pantetheine amidohydrolase | None | pantetheinase; vanin; vanin-1 | |
| 3.5.1.93 | glutaryl-7-aminocephalosporanic-acid acylase | False | 4 | 85 | 6 | 18 | (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate | (7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase | None | 7beta-(4-carboxybutanamido)cephalosporanic acid acylase; cephalosporin C acylase; glutaryl-7-ACA acylase; CA; GCA; GA; cephalosporin acylase; glutaryl-7-aminocephalosporanic acid acylase; GL-7-ACA acylase | |
| 3.5.2.1 | barbiturase | False | 3 | 504 | 5 | 4 | barbiturate + H2O = 3-oxo-3-ureidopropanoate | barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming) | None | None | |
| 3.5.2.2 | dihydropyrimidinase | False | 12 | 6903 | 22 | 72 | 5,6-dihydrouracil + H2O = 3-ureidopropanoate | 5,6-dihydropyrimidine amidohydrolase | None | hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase | |
| 3.5.2.3 | dihydroorotase | False | 344 | 45285 | 57 | 32 | (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate | (S)-dihydroorotate amidohydrolase | None | carbamoylaspartic dehydrase; dihydroorotate hydrolase | |
| 3.5.2.4 | carboxymethylhydantoinase | False | 0 | 1 | 0 | 2 | L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate | L-5-carboxymethylhydantoin amidohydrolase | None | hydantoin hydrolase | |
| 3.5.2.5 | allantoinase | False | 50 | 5839 | 6 | 28 | (S)-allantoin + H2O = allantoate | (S)-allantoin amidohydrolase | None | None | |
| 3.5.2.6 | beta-lactamase | False | 169 | 70703 | 1462 | 98 | a beta-lactam + H2O = a substituted beta-amino acid | beta-lactam hydrolase | None | penicillinase; cephalosporinase; neutrapen; penicillin beta-lactamase; exopenicillinase; ampicillinase; penicillin amido-beta-lactamhydrolase; penicillinase I; penicillinase II; beta-lactamase I; beta-lactamase II; beta-lactamase III; beta-lactamase A; beta-lactamase B; beta-lactamase C; beta-lactamase AME I; cephalosporin-beta-lactamase; carbapenemase | |
| 3.5.2.7 | imidazolonepropionase | False | 276 | 23289 | 6 | 14 | (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ | 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase | None | 4(5)-imidazolone-5(4)-propionic acid hydrolase; imidazolone propionic acid hydrolase | |
| 3.5.2.9 | 5-oxoprolinase (ATP-hydrolysing) | False | 252 | 19512 | 0 | 29 | ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate | 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) | None | pyroglutamase (ATP-hydrolysing); oxoprolinase; pyroglutamase; 5-oxoprolinase; pyroglutamate hydrolase; pyroglutamic hydrolase; L-pyroglutamate hydrolase; 5-oxo-L-prolinase; pyroglutamase | |
| 3.5.2.10 | creatininase | False | 1 | 2144 | 12 | 7 | creatinine + H2O = creatine | creatinine amidohydrolase | None | creatinine hydrolase | |
| 3.5.2.11 | L-lysine-lactamase | True | 0 | 0 | 0 | 1 | (S)-2-aminohexano-6-lactam + H2O = L-lysine | (S)-2-aminohexano-6-lactam lactamhydrolase | None | L-alpha-aminocaprolactam hydrolase; L-lysinamidase; L-lysine-1,6-lactam lactamhydrolase | |
| 3.5.2.12 | 6-aminohexanoate-cyclic-dimer hydrolase | False | 2 | 460 | 2 | 9 | 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate | 1,8-diazacyclotetradecane-2,9-dione lactamhydrolase | None | None | |
| 3.5.2.13 | 2,5-dioxopiperazine hydrolase | True | 0 | 0 | 0 | 2 | 2,5-dioxopiperazine + H2O = glycylglycine | 2,5-dioxopiperazine amidohydrolase | None | cyclo(Gly-Gly) hydrolase; cyclo(glycylglycine) hydrolase | |
| 3.5.2.14 | N-methylhydantoinase (ATP-hydrolysing) | False | 0 | 1842 | 0 | 2 | ATP + N-methylhydantoin + 2 H2O = ADP + phosphate + N-carbamoylsarcosine | N-methylhydantoin amidohydrolase (ATP-hydrolysing) | None | N-methylhydantoin amidohydrolase; methylhydantoin amidase; N-methylhydantoin hydrolase; N-methylhydantoinase; N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing) | |
| 3.5.2.15 | cyanuric acid amidohydrolase | False | 14 | 547 | 16 | 10 | cyanuric acid + H2O = 1-carboxybiuret | cyanuric acid amidohydrolase | None | atzD (gene name); trzD (gene name) | |
| 4.1.1.115 | indoleacetate decarboxylase | False | 1 | 0 | 0 | 2 | (1H-indol-3-yl)acetate = skatole + CO2 | (1H-indol-3-yl)acetate carboxy-lyase (skatole-forming) | None | IAD | |
| 3.5.2.16 | maleimide hydrolase | False | 0 | 27 | 0 | 7 | maleimide + H2O = maleamic acid | cyclic-imide amidohydrolase (ring-opening) | None | imidase; cyclic imide hydrolase; cyclic-imide amidohydrolase (decyclicizing) [misprint]; cyclic-imide amidohydrolase (decyclizing) | |
| 3.5.2.17 | hydroxyisourate hydrolase | False | 23 | 15682 | 5 | 13 | 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate | 5-hydroxyisourate amidohydrolase | None | HIUHase; 5-hydroxyisourate hydrolase | |
| 3.5.3.1 | arginase | False | 51 | 12833 | 148 | 52 | L-arginine + H2O = L-ornithine + urea | L-arginine amidinohydrolase | None | arginine amidinase; canavanase; L-arginase; arginine transamidinase | |
| 3.5.3.2 | guanidinoacetase | True | 0 | 0 | 0 | 5 | guanidinoacetate + H2O = glycine + urea | guanidinoacetate amidinohydrolase | None | glycocyaminase | |
| 3.5.3.3 | creatinase | False | 3 | 432 | 2 | 12 | creatine + H2O = sarcosine + urea | creatine amidinohydrolase | None | None | |
| 3.5.3.4 | allantoicase | False | 37 | 5309 | 2 | 23 | allantoate + H2O = (S)-ureidoglycolate + urea | allantoate amidinohydrolase | None | None | |
| 3.5.3.5 | formimidoylaspartate deiminase | True | 0 | 0 | 0 | 1 | N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3 | N-formimidoyl-L-aspartate iminohydrolase | None | formiminoaspartate deiminase | |
| 3.5.3.6 | arginine deiminase | False | 148 | 9356 | 9 | 42 | L-arginine + H2O = L-citrulline + NH3 | L-arginine iminohydrolase | None | arginine dihydrolase; citrulline iminase; L-arginine deiminase | |
| 3.5.3.7 | guanidinobutyrase | False | 6 | 665 | 1 | 28 | 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea | 4-guanidinobutanoate amidinohydrolase | None | gamma-guanidobutyrase; 4-guanidinobutyrate amidinobutyrase; gamma-guanidinobutyrate amidinohydrolase; G-Base; GBH; guanidinobutyrate ureahydrolase | |
| 3.5.3.8 | formimidoylglutamase | False | 95 | 5376 | 8 | 10 | N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide | N-formimidoyl-L-glutamate formimidoylhydrolase | None | formiminoglutamase; N-formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase | |
| 3.5.3.9 | allantoate deiminase | False | 6 | 799 | 0 | 7 | allantoate + H2O = (S)-ureidoglycine + NH3 + CO2 | allantoate amidinohydrolase (decarboxylating) | None | allantoate amidohydrolase | |
| 3.5.3.10 | D-arginase | False | 0 | 35 | 0 | 9 | D-arginine + H2O = D-ornithine + urea | D-arginine amidinohydrolase | None | None | |
| 3.5.3.11 | agmatinase | False | 75 | 14020 | 12 | 14 | agmatine + H2O = putrescine + urea | agmatine amidinohydrolase | None | agmatine ureohydrolase; SpeB | |
| 3.5.3.12 | agmatine deiminase | False | 60 | 5505 | 8 | 36 | agmatine + H2O = N-carbamoylputrescine + NH3 | agmatine iminohydrolase | None | agmatine amidinohydrolase | |
| 3.5.3.13 | formimidoylglutamate deiminase | False | 1 | 4260 | 0 | 4 | N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3 | N-formimidoyl-L-glutamate iminohydrolase | None | formiminoglutamate deiminase; formiminoglutamic iminohydrolase | |
| 3.5.3.14 | amidinoaspartase | True | 0 | 0 | 0 | 2 | N-amidino-L-aspartate + H2O = L-aspartate + urea | N-amidino-L-aspartate amidinohydrolase | None | amidinoaspartic amidinohydrolase | |
| 3.5.3.15 | protein-arginine deiminase | False | 15 | 2200 | 57 | 13 | protein L-arginine + H2O = protein L-citrulline + NH3 | protein-L-arginine iminohydrolase | None | peptidylarginine deiminase; PAD | |
| 3.5.3.16 | methylguanidinase | True | 0 | 0 | 0 | 1 | methylguanidine + H2O = methylamine + urea | methylguanidine amidinohydrolase | None | methylguanidine hydrolase | |
| 3.5.3.17 | guanidinopropionase | False | 4 | 122 | 2 | 1 | 3-guanidinopropanoate + H2O = beta-alanine + urea | 3-guanidinopropanoate amidinopropionase | None | GPase; GPH | |
| 3.5.3.18 | dimethylargininase | False | 7 | 671 | 24 | 11 | Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline | Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase | None | dimethylarginine dimethylaminohydrolase; NG,NG-dimethylarginine dimethylaminohydrolase; NG,NG-dimethyl-L-arginine dimethylamidohydrolase; omega,omega'-di-N-methyl-L-arginine dimethylamidohydrolase; Nomega,Nomega'-methyl-L-arginine dimethylamidohydrolase (incorrect) | |
| 3.5.3.20 | diguanidinobutanase | True | 0 | 0 | 0 | 1 | 1,4-diguanidinobutane + H2O = agmatine + urea | 1,4-diguanidinobutane amidinohydrolase | None | None | |
| 3.5.3.21 | methylenediurea deaminase | True | 0 | 0 | 0 | 1 | methylenediurea + 2 H2O = N-(hydroxymethyl)urea + 2 NH3 + CO2 (overall reaction);;(1a) methylenediurea + H2O = N-(carboxyaminomethyl)urea + NH3;;(1b) N-(carboxyaminomethyl)urea = N-(aminomethyl)urea + CO2 (spontaneous);;(1c) N-(aminomethyl)urea + H2O = N-(hydroxymethyl)urea + NH3 (spontaneous) | methylenediurea aminohydrolase | None | methylenediurease | |
| 3.5.3.22 | proclavaminate amidinohydrolase | False | 1 | 134 | 0 | 1 | amidinoproclavaminate + H2O = proclavaminate + urea | amidinoproclavaminate amidinohydrolase | None | PAH; proclavaminate amidino hydrolase | |
| 3.5.4.1 | cytosine deaminase | False | 4 | 4908 | 27 | 46 | cytosine + H2O = uracil + NH3 | cytosine aminohydrolase | None | isocytosine deaminase | |
| 3.5.4.2 | adenine deaminase | False | 223 | 22602 | 4 | 23 | adenine + H2O = hypoxanthine + NH3 | adenine aminohydrolase | None | adenase; adenine aminase; ADase | |
| 3.5.4.3 | guanine deaminase | False | 11 | 12388 | 11 | 27 | guanine + H2O = xanthine + NH3 | guanine aminohydrolase | None | guanase; guanine aminase; GAH | |
| 3.5.4.4 | adenosine deaminase | False | 208 | 23187 | 49 | 54 | (1) adenosine + H2O = inosine + NH3;;(2) 2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3 | adenosine aminohydrolase | None | deoxyadenosine deaminase | |
| 3.5.4.5 | cytidine deaminase | False | 135 | 26927 | 24 | 36 | (1) cytidine + H2O = uridine + NH3;;(2) 2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3 | cytidine/2'-deoxycytidine aminohydrolase | None | cytosine nucleoside deaminase; (deoxy)cytidine deaminase; cdd (gene name); CDA (gene name) | |
| 3.5.4.6 | AMP deaminase | False | 16 | 9553 | 2 | 30 | AMP + H2O = IMP + NH3 | AMP aminohydrolase | None | adenylic acid deaminase; AMP aminase; adenylic deaminase; adenylate deaminase; 5-AMP deaminase; adenosine 5-monophosphate deaminase; 5-adenylate deaminase; adenyl deaminase; 5-adenylic acid deaminase; adenosine monophosphate deaminase; adenylate aminohydrolase; adenylate desaminase; adenosine 5-phosphate aminohydrolase; 5-adenylate deaminase | |
| 3.5.4.7 | ADP deaminase | True | 0 | 0 | 0 | 8 | ADP + H2O = IDP + NH3 | ADP aminohydrolase | None | adenosine diphosphate deaminase; adenosinepyrophosphate deaminase | |
| 3.5.4.8 | aminoimidazolase | True | 0 | 0 | 0 | 1 | 4-aminoimidazole + H2O = imidazol-4-one + NH3 | 4-aminoimidazole aminohydrolase | None | 4-aminoimidazole hydrolase; 4-aminoimidazole deaminase | |
| 3.5.4.9 | methenyltetrahydrofolate cyclohydrolase | False | 823 | 51033 | 3 | 50 | 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate | 5,10-methenyltetrahydrofolate 5-hydrolase (ring-opening) | None | Citrovorum factor cyclodehydrase; cyclohydrolase; formyl-methenyl-methylenetetrahydrofolate synthetase (combined); 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) | |
| 3.5.4.10 | IMP cyclohydrolase | False | 492 | 38961 | 5 | 16 | IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | IMP 1,2-hydrolase (ring-opening) | None | inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing) | |
| 3.5.4.11 | pterin deaminase | False | 2 | 209 | 0 | 7 | a 2-amino-4-hydroxypteridine + H2O = a 2,4-dihydroxypteridine + NH3 | 2-amino-4-hydroxypteridine aminohydrolase | None | acrasinase | |
| 3.5.4.12 | dCMP deaminase | False | 11 | 974 | 4 | 24 | dCMP + H2O = dUMP + NH3 | dCMP aminohydrolase | None | deoxycytidylate deaminase; deoxy-CMP-deaminase; deoxycytidylate aminohydrolase; deoxycytidine monophosphate deaminase; deoxycytidine-5'-phosphate deaminase; deoxycytidine-5'-monophosphate aminohydrolase | |
| 3.5.4.13 | dCTP deaminase | False | 335 | 16933 | 16 | 9 | dCTP + H2O = dUTP + NH3 | dCTP aminohydrolase | None | deoxycytidine triphosphate deaminase; 5-methyl-dCTP deaminase | |
| 3.5.4.15 | guanosine deaminase | False | 1 | 0 | 16 | 5 | guanosine + H2O = xanthosine + NH3 | guanosine aminohydrolase | None | guanosine aminase | |
| 3.5.4.16 | GTP cyclohydrolase I | False | 551 | 50458 | 32 | 27 | GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate | GTP 7,8-8,9-dihydrolase | None | GTP cyclohydrolase; guanosine triphosphate cyclohydrolase; guanosine triphosphate 8-deformylase; dihydroneopterin triphosphate synthase; GTP 8-formylhydrolase | |
| 3.5.4.17 | adenosine-phosphate deaminase | False | 0 | 1 | 0 | 8 | (1) AMP + H2O = IMP + NH3;;(2) ADP + H2O = IDP + NH3;;(3) ATP + H2O = ITP + NH3 | adenosine-phosphate aminohydrolase | None | adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase | |
| 3.5.4.18 | ATP deaminase | True | 0 | 0 | 0 | 6 | ATP + H2O = ITP + NH3 | ATP aminohydrolase | None | adenosine triphosphate deaminase | |
| 3.5.4.19 | phosphoribosyl-AMP cyclohydrolase | False | 359 | 37459 | 5 | 6 | 1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide | 1-(5-phospho-beta-D-ribosyl)-AMP 1,6-hydrolase | None | PRAMP-cyclohydrolase; phosphoribosyladenosine monophosphate cyclohydrolase; 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase | |
| 3.5.4.20 | pyrithiamine deaminase | True | 0 | 0 | 0 | 1 | 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH3 | 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium aminohydrolase | None | 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase | |
| 3.5.4.21 | creatinine deaminase | False | 0 | 30 | 0 | 14 | creatinine + H2O = N-methylhydantoin + NH3 | creatinine iminohydrolase | None | creatinine hydrolase; creatinine desiminase | |
| 3.5.4.22 | 1-pyrroline-4-hydroxy-2-carboxylate deaminase | False | 0 | 87 | 3 | 1 | 1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3 | 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (ring-opening) | None | HPC deaminase; 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing) | |
| 3.5.4.23 | blasticidin-S deaminase | False | 4 | 69 | 7 | 11 | blasticidin S + H2O = deaminohydroxyblasticidin S + NH3 | blasticidin-S aminohydrolase | None | None | |
| 3.5.4.24 | sepiapterin deaminase | True | 0 | 0 | 0 | 1 | sepiapterin + H2O = xanthopterin-B2 + NH3 | sepiapterin aminohydrolase | None | None | |
| 3.5.4.25 | GTP cyclohydrolase II | False | 221 | 35401 | 3 | 11 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate | GTP 7,8-8,9-dihydrolase (formate-releasing, phosphate-releasing) | None | guanosine triphosphate cyclohydrolase II; GTP-8-formylhydrolase; ribA (gene name); GTP 7,8-8,9-dihydrolase (diphosphate-forming) | |
| 3.5.4.26 | diaminohydroxyphosphoribosylaminopyrimidine deaminase | False | 20 | 34446 | 10 | 3 | 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH3 | 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine 2-aminohydrolase | None | None | |
| 3.5.4.27 | methenyltetrahydromethanopterin cyclohydrolase | False | 38 | 3156 | 5 | 24 | 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin | 5,10-methenyltetrahydromethanopterin 10-hydrolase (ring-opening) | None | 5,10-methenyltetrahydromethanopterin cyclohydrolase; N5,N10-methenyltetrahydromethanopterin cyclohydrolase; methenyl-H4MPT cyclohydrolase; 5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing) | |
| 3.5.4.28 | S-adenosylhomocysteine deaminase | False | 77 | 8171 | 2 | 2 | S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3 | S-adenosyl-L-homocysteine aminohydrolase | None | adenosylhomocysteine deaminase | |
| 3.5.4.29 | GTP cyclohydrolase IIa | False | 27 | 976 | 1 | 1 | GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate | GTP 8,9-hydrolase (phosphate-forming) | None | None | |
| 3.5.4.30 | dCTP deaminase (dUMP-forming) | False | 94 | 6911 | 3 | 3 | dCTP + 2 H2O = dUMP + diphosphate + NH3 | dCTP aminohydrolase (dUMP-forming) | None | None | |
| 3.5.5.1 | nitrilase | False | 34 | 2736 | 3 | 100 | a nitrile + 2 H2O = a carboxylate + NH3 | nitrile aminohydrolase | None | acetonitrilase; benzonitrilase | |
| 3.5.5.2 | ricinine nitrilase | True | 0 | 0 | 0 | 1 | ricinine + 2 H2O = 3-carboxy-4-methoxy-N-methyl-2-pyridone + NH3 | ricinine aminohydrolase | None | None | |
| 3.5.5.4 | cyanoalanine nitrilase | False | 6 | 493 | 0 | 36 | 3-cyano-L-alanine + 2 H2O = L-aspartate + NH3 (overall reaction);;(1a) 3-cyano-L-alanine + H2O = L-asparagine;;(1b) L-asparagine + H2O = L-aspartate + NH3 | 3-cyano-L-alanine aminohydrolase | None | beta-cyanoalanine nitrilase | |
| 3.5.5.5 | arylacetonitrilase | False | 10 | 3 | 0 | 16 | 4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH3 | arylacetonitrile aminohydrolase | None | None | |
| 3.5.5.6 | bromoxynil nitrilase | True | 0 | 0 | 0 | 1 | 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH3 | 3,5-dibromo-4-hydroxybenzonitrile aminohydrolase | None | None | |
| 3.5.5.7 | aliphatic nitrilase | False | 3 | 675 | 0 | 63 | R-CN + 2 H2O = R-COOH + NH3 | aliphatic nitrile aminohydrolase | None | None | |
| 3.5.5.8 | thiocyanate hydrolase | False | 3 | 211 | 6 | 5 | thiocyanate + 2 H2O = carbonyl sulfide + NH3 + HO- | thiocyanate aminohydrolase | None | None | |
| 3.5.99.1 | riboflavinase | False | 0 | 1 | 0 | 1 | riboflavin + H2O = ribitol + lumichrome | riboflavin hydrolase | None | None | |
| 3.5.99.2 | aminopyrimidine aminohydrolase | False | 22 | 8838 | 5 | 10 | (1) 4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH3;;(2) thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole | 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase | None | thiaminase (ambiguous); thiaminase II; tenA (gene name) | |
| 3.5.99.5 | 2-aminomuconate deaminase | False | 3 | 439 | 1 | 4 | 2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 | 2-aminomuconate aminohydrolase | None | amnD (gene name); nbaF (gene name) | |
| 3.5.99.6 | glucosamine-6-phosphate deaminase | False | 287 | 20329 | 14 | 22 | alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3 | 2-amino-2-deoxy-alpha-D-glucose-6-phosphate aminohydrolase (ketol isomerizing) | None | glucosaminephosphate isomerase (ambiguous); glucosamine-6-phosphate isomerase (ambiguous); phosphoglucosaminisomerase (ambiguous); glucosamine phosphate deaminase; aminodeoxyglucosephosphate isomerase (ambiguous); phosphoglucosamine isomerase (ambiguous); 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing) | |
| 3.5.99.7 | 1-aminocyclopropane-1-carboxylate deaminase | False | 54 | 2825 | 6 | 91 | 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3 (overall reaction);;(1a) 1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate;;(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);;(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) | 1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing) | None | 1-aminocyclopropane-1-carboxylate endolyase (deaminating); ACC deaminase; 1-aminocyclopropane carboxylic acid deaminase | |
| 3.6.1.1 | inorganic diphosphatase | False | 286 | 55326 | 131 | 94 | diphosphate + H2O = 2 phosphate | diphosphate phosphohydrolase | None | None | |
| 3.6.1.2 | trimetaphosphatase | True | 0 | 0 | 0 | 9 | trimetaphosphate + H2O = triphosphate | trimetaphosphate hydrolase | None | inorganic trimetaphosphatase | |
| 3.6.1.5 | apyrase | False | 31 | 2973 | 34 | 62 | a nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate (overall reaction);;(1a) a nucleoside 5'-triphosphate + H2O = a nucleoside 5'-diphosphate + phosphate;;(1b) a nucleoside 5'-diphosphate + H2O = a nucleoside 5'-phosphate + phosphate | nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming) | None | ATP-diphosphatase (ambiguous); adenosine diphosphatase; ADPase; ATP diphosphohydrolase [ambiguous] | |
| 3.6.1.6 | nucleoside diphosphate phosphatase | False | 116 | 3162 | 4 | 17 | a nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate | nucleoside-diphosphate phosphohydrolase | None | nucleoside-diphosphatase; thiaminpyrophosphatase; UDPase; inosine diphosphatase; adenosine diphosphatase; IDPase; ADPase; adenosinepyrophosphatase; guanosine diphosphatase; guanosine 5'-diphosphatase; inosine 5'-diphosphatase; uridine diphosphatase; uridine 5'-diphosphatase; type B nucleoside diphosphatase; GDPase; CDPase; nucleoside 5'-diphosphatase; type L nucleoside diphosphatase; NDPase; nucleoside diphosphate phosphohydrolase | |
| 3.6.1.7 | acylphosphatase | False | 271 | 30812 | 35 | 22 | an acylphosphate + H2O = a carboxylate + phosphate | acylphosphate phosphohydrolase | None | acetylphosphatase; 1,3-diphosphoglycerate phosphatase; acetic phosphatase; Ho 1-3; GP 1-3 | |
| 3.6.1.8 | ATP diphosphatase | False | 5 | 1834 | 1 | 9 | ATP + H2O = AMP + diphosphate | ATP diphosphohydrolase (diphosphate-forming) | None | ATPase (ambiguous); ATP pyrophosphatase; adenosine triphosphate pyrophosphatase; ATP diphosphohydrolase (ambiguous) | |
| 3.6.1.9 | nucleotide diphosphatase | False | 530 | 53897 | 26 | 32 | a nucleoside triphosphate + H2O = a nucleotide + diphosphate | nucleoside-triphosphate diphosphohydrolase | None | ENPP1 (gene name); nucleotide pyrophosphatase; nucleotide-sugar pyrophosphatase; nucleoside-triphosphate diphosphatase | |
| 3.6.1.10 | endopolyphosphatase | False | 15 | 1238 | 0 | 15 | polyphosphate + n H2O = (n+1) oligophosphate | polyphosphate polyphosphohydrolase | None | polyphosphate depolymerase; metaphosphatase; polyphosphatase; polymetaphosphatase | |
| 3.6.1.11 | exopolyphosphatase | False | 77 | 13234 | 11 | 31 | (polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate | polyphosphate phosphohydrolase | None | metaphosphatase; acid phosphoanhydride phosphohydrolase; Gra-Pase | |
| 3.6.1.12 | dCTP diphosphatase | False | 48 | 2156 | 4 | 5 | dCTP + H2O = dCMP + diphosphate | dCTP nucleotidohydrolase | None | DCTPP1 (gene name); deoxycytidine-triphosphatase; dCTPase; dCTP pyrophosphatase; deoxycytidine triphosphatase; deoxy-CTPase | |
| 3.6.1.13 | ADP-ribose diphosphatase | False | 32 | 11127 | 106 | 21 | ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate | ADP-D-ribose ribophosphohydrolase | None | ADPribose pyrophosphatase; adenosine diphosphoribose pyrophosphatase; ADPR-PPase; ADP-ribose ribophosphohydrolase | |
| 3.6.1.14 | adenosine-tetraphosphatase | False | 0 | 20 | 1 | 4 | adenosine 5'-tetraphosphate + H2O = ATP + phosphate | adenosine-tetraphosphate phosphohydrolase | None | None | |
| 3.6.1.15 | nucleoside-triphosphate phosphatase | False | 402 | 11988 | 49 | 53 | a nucleoside triphosphate + H2O = a nucleoside diphosphate + phosphate | nucleoside-triphosphate phosphohydrolase | None | nucleoside-triphosphatase; nucleoside triphosphate phosphohydrolase; nucleoside-5-triphosphate phosphohydrolase; nucleoside 5-triphosphatase; unspecific diphosphate phosphohydrolase | |
| 3.6.1.16 | CDP-glycerol diphosphatase | False | 9 | 1112 | 0 | 1 | CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate | CDP-glycerol phosphoglycerohydrolase | None | CDP-glycerol pyrophosphatase; cytidine diphosphoglycerol pyrophosphatase | |
| 3.6.1.17 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) | False | 32 | 2035 | 12 | 21 | P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP | P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase | None | bis(5'-guanosyl)-tetraphosphatase; bis(5'-adenosyl)-tetraphosphatase; diguanosinetetraphosphatase (asymmetrical); dinucleosidetetraphosphatase (asymmetrical); diadenosine P1,P4-tetraphosphatase; dinucleoside tetraphosphatase; 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase | |
| 3.6.1.18 | FAD diphosphatase | False | 1 | 46 | 0 | 9 | FAD + H2O = AMP + FMN | FAD nucleotidohydrolase | None | FAD pyrophosphatase; riboflavin adenine dinucleotide pyrophosphatase; flavin adenine dinucleotide pyrophosphatase; riboflavine adenine dinucleotide pyrophosphatase; flavine adenine dinucleotide pyrophosphatase | |
| 3.6.1.20 | 5'-acylphosphoadenosine hydrolase | True | 0 | 0 | 0 | 1 | 5'-acylphosphoadenosine + H2O = AMP + a carboxylate | 5'-acylphosphoadenosine acylhydrolase | None | 5-phosphoadenosine hydrolase | |
| 3.6.1.21 | ADP-sugar diphosphatase | False | 1 | 16 | 0 | 6 | ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate | ADP-sugar sugarphosphohydrolase | None | ADP-sugar pyrophosphatase; adenosine diphosphosugar pyrophosphatase | |
| 3.6.1.22 | NAD+ diphosphatase | False | 116 | 23453 | 7 | 15 | NAD(H) + H2O = AMP + NMN(H) | NAD(H) phosphohydrolase | None | NPY1 (gene name); nudC (gene name); NUDT7 (gene name); nicotinamide adenine dinucleotide pyrophosphatase; NADP pyrophosphatase; NADH pyrophosphatase; NAD+ phosphohydrolase | |
| 3.6.1.23 | dUTP diphosphatase | False | 561 | 43016 | 141 | 55 | dUTP + H2O = dUMP + diphosphate | dUTP nucleotidohydrolase | None | DUT (gene name); deoxyuridine-triphosphatase; dUTPase; dUTP pyrophosphatase; desoxyuridine 5'-triphosphate nucleotidohydrolase; desoxyuridine 5'-triphosphatase | |
| 3.6.1.24 | nucleoside phosphoacylhydrolase | False | 0 | 1 | 0 | 1 | Hydrolyses mixed phospho-anhydride bonds | nucleoside-5'-phosphoacylate acylhydrolase | None | None | |
| 3.6.1.25 | triphosphatase | False | 5 | 279 | 2 | 5 | triphosphate + H2O = diphosphate + phosphate | triphosphate phosphohydrolase | None | inorganic triphosphatase | |
| 3.6.1.26 | CDP-diacylglycerol diphosphatase | False | 46 | 2705 | 1 | 2 | CDP-diacylglycerol + H2O = CMP + phosphatidate | CDP-diacylglycerol phosphatidylhydrolase | None | cytidine diphosphodiacylglycerol pyrophosphatase; CDP diacylglycerol hydrolase | |
| 3.6.1.27 | undecaprenyl-diphosphate phosphatase | False | 647 | 56448 | 5 | 9 | ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate | ditrans,octacis-undecaprenyl-diphosphate phosphohydrolase | None | C55-isoprenyl diphosphatase; C55-isoprenyl pyrophosphatase; isoprenyl pyrophosphatase (ambiguous); undecaprenyl pyrophosphate phosphatase; undecaprenyl pyrophosphate pyrophosphatase; UPP phosphatase; Und-PP pyrophosphatase; UppP (ambiguous); BacA; undecaprenyl-diphosphate phosphohydrolase; undecaprenyl-diphosphatase | |
| 3.6.1.28 | thiamine-triphosphatase | False | 5 | 496 | 5 | 10 | thiamine triphosphate + H2O = thiamine diphosphate + phosphate | thiamine-triphosphate phosphohydrolase | None | None | |
| 3.6.1.29 | bis(5'-adenosyl)-triphosphatase | False | 21 | 2783 | 8 | 9 | P1,P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP | P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase | None | dinucleosidetriphosphatase; diadenosine 5,5-P1,P3-triphosphatase; 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase | |
| 3.6.1.31 | phosphoribosyl-ATP diphosphatase | False | 347 | 32771 | 5 | 4 | 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate | 1-(5-phospho-beta-D-ribosyl)-ATP diphosphohydrolase | None | phosphoribosyl-ATP pyrophosphatase; phosphoribosyladenosine triphosphate pyrophosphatase; 1-(5-phosphoribosyl)-ATP diphosphohydrolase | |
| 3.6.1.39 | thymidine-triphosphatase | True | 0 | 0 | 0 | 4 | dTTP + H2O = dTDP + phosphate | dTTP nucleotidohydrolase | None | thymidine triphosphate nucleotidohydrolase; dTTPase; deoxythymidine-5'-triphosphatase | |
| 3.6.1.40 | guanosine-5'-triphosphate,3'-diphosphate phosphatase | False | 77 | 3650 | 1 | 4 | guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate | guanosine-5'-triphosphate-3'-diphosphate 5'-phosphohydrolase | None | pppGpp 5'-phosphohydrolase; guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase; guanosine pentaphosphatase; guanosine pentaphosphate phosphatase; guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase; guanosine pentaphosphate phosphohydrolase | |
| 3.6.1.41 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) | False | 203 | 17051 | 12 | 7 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP | P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase | None | diadenosinetetraphosphatase (symmetrical); dinucleosidetetraphosphatasee (symmetrical); symmetrical diadenosine tetraphosphate hydrolase; adenosine tetraphosphate phosphodiesterase; Ap4A hydrolase; bis(5'-adenosyl) tetraphosphatase; diadenosine tetraphosphate hydrolase; diadenosine polyphosphate hydrolase; diadenosine 5',5'''-P1,P4-tetraphosphatase; diadenosinetetraphosphatase (symmetrical); 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase | |
| 3.6.1.42 | guanosine-diphosphatase | False | 7 | 1760 | 0 | 11 | GDP + H2O = GMP + phosphate | GDP phosphohydrolase | None | GDPase | |
| 3.6.1.43 | dolichyldiphosphatase | False | 10 | 2522 | 0 | 6 | dolichyl diphosphate + H2O = dolichyl phosphate + phosphate | dolichyl-diphosphate phosphohydrolase | None | dolichol diphosphatase; dolichyl pyrophosphatase; dolichyl pyrophosphate phosphatase; dolichyl diphosphate phosphohydrolase; Dol-P-P phosphohydrolase | |
| 3.6.1.44 | oligosaccharide-diphosphodolichol diphosphatase | True | 0 | 0 | 0 | 2 | oligosaccharide-diphosphodolichol + H2O = oligosaccharide phosphate + dolichyl phosphate | oligosaccharide-diphosphodolichol phosphodolichohydrolase | None | oligosaccharide-diphosphodolichol pyrophosphatase | |
| 3.6.1.45 | UDP-sugar diphosphatase | False | 12 | 1136 | 33 | 11 | UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate | UDP-sugar sugarphosphohydrolase | None | nucleosidediphosphate-sugar pyrophosphatase; nucleosidediphosphate-sugar diphosphatase; UDP-sugar hydrolase; UDP-sugar pyrophosphatase | |
| 3.6.1.52 | diphosphoinositol-polyphosphate diphosphatase | False | 31 | 2433 | 40 | 6 | diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate | diphospho-myo-inositol-polyphosphate diphosphohydrolase | None | diphosphoinositol-polyphosphate phosphohydrolase; DIPP | |
| 3.6.2.1 | adenylylsulfatase | False | 8 | 29 | 0 | 3 | adenylyl sulfate + H2O = AMP + sulfate | adenylyl-sulfate sulfohydrolase | None | adenosine 5-phosphosulfate sulfohydrolase; adenylylsulfate sulfohydrolase | |
| 3.6.2.2 | phosphoadenylylsulfatase | True | 0 | 0 | 0 | 4 | 3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + sulfate | 3'-phosphoadenylyl-sulfate sulfohydrolase | None | 3-phosphoadenylyl sulfatase; 3-phosphoadenosine 5-phosphosulfate sulfatase; PAPS sulfatase; 3'-phosphoadenylylsulfate sulfohydrolase | |
| 3.6.4.6 | vesicle-fusing ATPase | False | 35 | 11413 | 135 | 25 | ATP + H2O = ADP + phosphate | ATP phosphohydrolase (vesicle-fusing) | None | None | |
| 3.6.4.7 | peroxisome-assembly ATPase | False | 0 | 89 | 0 | 14 | ATP + H2O = ADP + phosphate | ATP phosphohydrolase (peroxisome-assembling) | None | peroxisome assembly factor-2 | |
| 3.6.4.10 | non-chaperonin molecular chaperone ATPase | False | 78 | 4369 | 52 | 46 | ATP + H2O = ADP + phosphate | ATP phosphohydrolase (polypeptide-polymerizing) | None | molecular chaperone Hsc70 ATPase | |
| 3.6.5.1 | heterotrimeric G-protein GTPase | False | 0 | 98 | 12 | 28 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (signalling) | None | None | |
| 3.6.5.2 | small monomeric GTPase | False | 374 | 33523 | 354 | 45 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (cell-regulating) | None | None | |
| 3.6.5.3 | protein-synthesizing GTPase | False | 54 | 9705 | 17 | 45 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (mRNA-translation-assisting) | None | elongation factor (EF); initiation factor (IF); peptide-release or termination factor | |
| 3.6.5.4 | signal-recognition-particle GTPase | False | 145 | 77649 | 4 | 36 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (protein-synthesis-assisting) | None | None | |
| 3.6.5.5 | dynamin GTPase | False | 38 | 13754 | 38 | 20 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (vesicle-releasing) | None | None | |
| 3.6.5.6 | tubulin GTPase | False | 0 | 44 | 6 | 15 | GTP + H2O = GDP + phosphate | GTP phosphohydrolase (microtubule-releasing) | None | None | |
| 3.7.1.1 | oxaloacetase | False | 1 | 3 | 3 | 10 | oxaloacetate + H2O = oxalate + acetate | oxaloacetate acetylhydrolase | None | oxalacetic hydrolase | |
| 3.7.1.2 | fumarylacetoacetase | False | 10 | 15442 | 6 | 17 | 4-fumarylacetoacetate + H2O = acetoacetate + fumarate | 4-fumarylacetoacetate fumarylhydrolase | None | beta-diketonase; fumarylacetoacetate hydrolase | |
| 3.7.1.3 | kynureninase | False | 83 | 15360 | 4 | 27 | L-kynurenine + H2O = anthranilate + L-alanine | L-kynurenine hydrolase | None | None | |
| 3.7.1.4 | phloretin hydrolase | False | 2 | 19 | 0 | 10 | phloretin + H2O = phloretate + phloroglucinol | phloretin acylhydrolase (phloroglucinol-forming) | None | ErPhy; lactase-phlorerin hydrolase; C-acylphenol hydrolase; 2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase (incorrect) | |
| 3.7.1.5 | acylpyruvate hydrolase | False | 6 | 749 | 4 | 4 | a 3-acylpyruvate + H2O = a carboxylate + pyruvate | 3-acylpyruvate acylhydrolase | None | None | |
| 3.7.1.6 | acetylpyruvate hydrolase | False | 0 | 1 | 0 | 1 | acetylpyruvate + H2O = acetate + pyruvate | 2,4-dioxopentanoate acetylhydrolase | None | None | |
| 3.7.1.7 | beta-diketone hydrolase | False | 2 | 13 | 10 | 4 | nonane-4,6-dione + H2O = pentan-2-one + butanoate | nonane-4,6-dione acylhydrolase | None | oxidized PVA hydrolase | |
| 3.7.1.8 | 2,6-dioxo-6-phenylhexa-3-enoate hydrolase | False | 10 | 547 | 18 | 14 | 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate | 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase | None | HOHPDA hydrolase | |
| 3.7.1.9 | 2-hydroxymuconate-6-semialdehyde hydrolase | False | 2 | 369 | 10 | 10 | 2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate | 2-hydroxymuconate-6-semialdehyde formylhydrolase | None | 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase; 2-hydroxymuconic semialdehyde hydrolase; HMSH; HOD hydrolase; xylF (gene name); 2-hydroxymuconate-semialdehyde formylhydrolase; 2-hydroxymuconate-semialdehyde hydrolase | |
| 3.7.1.10 | cyclohexane-1,3-dione hydrolase | True | 0 | 0 | 0 | 2 | cyclohexane-1,3-dione + H2O = 5-oxohexanoate | cyclohexane-1,3-dione acylhydrolase (ring-opening) | None | 1,3-cyclohexanedione hydrolase; cyclohexane-1,3-dione acylhydrolase (decyclizing) | |
| 3.8.1.2 | (S)-2-haloacid dehalogenase | False | 9 | 10592 | 27 | 21 | (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide | (S)-2-haloacid halidohydrolase | None | 2-haloacid dehalogenase[ambiguous]; 2-haloacid halidohydrolase [ambiguous][ambiguous]; 2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; 2-halocarboxylic acid dehalogenase II; DL-2-haloacid dehalogenase[ambiguous]; L-2-haloacid dehalogenase; L-DEX | |
| 3.8.1.3 | haloacetate dehalogenase | False | 4 | 1226 | 46 | 15 | haloacetate + H2O = glycolate + halide | haloacetate halidohydrolase | None | monohaloacetate dehalogenase | |
| 3.8.1.5 | haloalkane dehalogenase | False | 33 | 4379 | 113 | 50 | 1-haloalkane + H2O = a primary alcohol + halide | 1-haloalkane halidohydrolase | None | 1-chlorohexane halidohydrolase; 1-haloalkane dehalogenase | |
| 3.8.1.6 | 4-chlorobenzoate dehalogenase | False | 0 | 1 | 3 | 4 | 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride | 4-chlorobenzoate chlorohydrolase | None | halobenzoate dehalogenase | |
| 3.8.1.7 | 4-chlorobenzoyl-CoA dehalogenase | False | 3 | 301 | 0 | 5 | 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride | 4-chlorobenzoyl CoA chlorohydrolase | None | None | |
| 3.8.1.8 | atrazine chlorohydrolase | False | 1 | 303 | 7 | 16 | atrazine + H2O = hydroxyatrazine + chloride | atrazine chlorohydrolase | None | AtzA | |
| 3.8.1.9 | (R)-2-haloacid dehalogenase | False | 2 | 17 | 4 | 4 | (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide | (R)-2-haloacid halidohydrolase | None | 2-haloalkanoic acid dehalogenase[ambiguous]; 2-haloalkanoid acid halidohydrolase[ambiguous]; D-2-haloacid dehalogenase; D-DEX | |
| 3.8.1.10 | 2-haloacid dehalogenase (configuration-inverting) | False | 2 | 8 | 2 | 8 | (1) (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide;;(2) (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide | (S)-2-haloacid dehalogenase (configuration-inverting) | None | 2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; DL-2-haloacid dehalogenase; DL-2-haloacid dehalogenase (inversion of configuration); DL-2-haloacid halidohydrolase (inversion of configuration); DL-DEXi; (R,S)-2-haloacid dehalogenase (configuration-inverting) | |
| 3.8.1.11 | 2-haloacid dehalogenase (configuration-retaining) | False | 0 | 1 | 0 | 1 | (1) (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide;;(2) (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide | (S)-2-haloacid dehalogenase (configuration-retaining) | None | 2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; DL-2-haloacid dehalogenase; DL-DEXr | |
| 3.9.1.1 | phosphoamidase | False | 5 | 25 | 0 | 3 | N-phosphocreatine + H2O = creatine + phosphate | phosphamide hydrolase | None | creatine phosphatase | |
| 3.10.1.1 | N-sulfoglucosamine sulfohydrolase | False | 1 | 73 | 2 | 5 | N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate | N-sulfo-D-glucosamine sulfohydrolase | None | sulfoglucosamine sulfamidase; heparin sulfamidase; 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase) | |
| 3.10.1.2 | cyclamate sulfohydrolase | True | 0 | 0 | 0 | 1 | cyclohexylsulfamate + H2O = cyclohexylamine + sulfate | cyclohexylsulfamate sulfohydrolase | None | cyclamate sulfamatase; cyclamate sulfamidase; cyclohexylsulfamate sulfamidase | |
| 3.11.1.1 | phosphonoacetaldehyde hydrolase | False | 67 | 4498 | 2 | 7 | phosphonoacetaldehyde + H2O = acetaldehyde + phosphate | 2-oxoethylphosphonate phosphonohydrolase | None | phosphonatase; 2-phosphonoacetylaldehyde phosphonohydrolase | |
| 3.11.1.2 | phosphonoacetate hydrolase | False | 4 | 1024 | 1 | 21 | phosphonoacetate + H2O = acetate + phosphate | phosphonoacetate phosphonohydrolase | None | None | |
| 3.12.1.1 | trithionate hydrolase | True | 0 | 0 | 0 | 11 | trithionate + H2O = thiosulfate + sulfate + 2 H+ | trithionate thiosulfohydrolase | None | None | |
| 3.13.1.1 | UDP-sulfoquinovose synthase | False | 3 | 359 | 0 | 9 | UDP-alpha-D-sulfoquinovopyranose + H2O = UDP-alpha-D-glucose + sulfite | UDP-6-sulfo-6-deoxy-alpha-D-glucose sulfohydrolase | None | sulfite:UDP-glucose sulfotransferase; UDPsulfoquinovose synthase; UDP-6-sulfo-6-deoxyglucose sulfohydrolase | |
| 3.13.1.3 | 2'-hydroxybiphenyl-2-sulfinate desulfinase | False | 3 | 84 | 3 | 5 | 2'-hydroxybiphenyl-2-sulfinate + H2O = 2-hydroxybiphenyl + sulfite | 2'-hydroxybiphenyl-2-sulfinate sulfohydrolase | None | gene dszB-encoded hydrolase; 2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase; DszB; HBPSi desulfinase; 2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase; HPBS desulfinase; 2-(2-hydroxyphenyl)benzenesulfinate hydrolase; 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase; 2-(2-hydroxyphenyl)benzenesulfinate desulfinase | |
| 3.4.11.1 | leucyl aminopeptidase | False | 440 | 31354 | 50 | 94 | Release of an N-terminal amino acid, Xaa!Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low | None | None | leucine aminopeptidase; leucyl peptidase; peptidase S; cytosol aminopeptidase; cathepsin III; L-leucine aminopeptidase; leucinaminopeptidase; leucinamide aminopeptidase; FTBL proteins; proteinates FTBL; aminopeptidase II; aminopeptidase III; aminopeptidase I | |
| 3.4.11.2 | membrane alanyl aminopeptidase | False | 29 | 42693 | 92 | 52 | Release of an N-terminal amino acid, Xaa!Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide | None | None | microsomal aminopeptidase; aminopeptidase M; aminopeptidase N; particle-bound aminopeptidase; amino-oligopeptidase; alanine aminopeptidase; membrane aminopeptidase I; pseudo leucine aminopeptidase; alanyl aminopeptidase; alanine-specific aminopeptidase; cysteinylglycine dipeptidase; cysteinylglycinase; L-alanine aminopeptidase; CD13 | |
| 3.4.11.3 | cystinyl aminopeptidase | False | 3 | 7 | 8 | 13 | Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4] | None | None | cystyl-aminopeptidase; oxytocinase; cystine aminopeptidase; L-cystine aminopeptidase; oxytocin peptidase; vasopresssinase | |
| 3.4.11.4 | tripeptide aminopeptidase | False | 205 | 14306 | 1 | 21 | Release of the N-terminal residue from a tripeptide | None | None | tripeptidase; aminotripeptidase; aminoexotripeptidase; lymphopeptidase; imidoendopeptidase; peptidase B; alanine-phenylalanine-proline arylamidase; peptidase T | |
| 3.4.11.5 | prolyl aminopeptidase | False | 52 | 23501 | 21 | 56 | Release of N-terminal proline from a peptide | None | None | proline aminopeptidase; Pro-X aminopeptidase; cytosol aminopeptidase V; proline iminopeptidase | |
| 3.4.11.6 | aminopeptidase B | False | 5 | 725 | 1 | 33 | Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys | None | None | arylamidase II; arginine aminopeptidase; arginyl aminopeptidase; Cl--activated arginine aminopeptidase; cytosol aminopeptidase IV; L-arginine aminopeptidase | |
| 3.4.11.7 | glutamyl aminopeptidase | False | 9 | 999 | 8 | 38 | Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide | None | None | aminopeptidase A; aspartate aminopeptidase; angiotensinase A; glutamyl peptidase; Ca2+-activated glutamate aminopeptidase; membrane aminopeptidase II; antigen BP-1/6C3 of mouse B lymphocytes; L-aspartate aminopeptidase; angiotensinase A2 | |
| 3.4.11.9 | Xaa-Pro aminopeptidase | False | 152 | 8730 | 31 | 31 | Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide | None | None | proline aminopeptidase; aminopeptidase P; aminoacylproline aminopeptidase; X-Pro aminopeptidase | |
| 3.4.11.10 | bacterial leucyl aminopeptidase | False | 418 | 27794 | 23 | 24 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids | None | None | Aeromonas proteolytica aminopeptidase | |
| 3.4.11.13 | clostridial aminopeptidase | True | 0 | 0 | 0 | 1 | Release of any N-terminal amino acid, including proline and hydroxyproline, but no cleavage of Xaa-Pro- | None | None | Clostridium histolyticum aminopeptidase | |
| 3.4.11.14 | cytosol alanyl aminopeptidase | False | 5 | 40 | 3 | 11 | Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides | None | None | arylamidase; aminopolypeptidase; thiol-activated aminopeptidase; human liver aminopeptidase; puromycin-sensitive aminopeptidase; soluble alanyl aminopeptidase; cytosol aminopeptidase III; alanine aminopeptidase | |
| 3.4.11.15 | aminopeptidase Y | False | 2 | 228 | 1 | 7 | Preferentially, release of N-terminal lysine | None | None | aminopeptidase Co; aminopeptidase (cobalt-activated); lysyl aminopeptidase | |
| 3.4.11.16 | Xaa-Trp aminopeptidase | True | 0 | 0 | 0 | 2 | Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on Glu!Trp, Leu!Trp and a number of other dipeptides | None | None | aminopeptidase W; aminopeptidase X-Trp; X-Trp aminopeptidase | |
| 3.4.11.17 | tryptophanyl aminopeptidase | False | 5 | 0 | 0 | 2 | Preferential release of N-terminal tryptophan | None | None | tryptophan aminopeptidase; L-tryptophan aminopeptidase | |
| 3.4.11.18 | methionyl aminopeptidase | False | 178 | 75740 | 175 | 35 | Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides | None | None | methionine aminopeptidase; peptidase M; L-methionine aminopeptidase; MAP | |
| 3.4.11.19 | D-stereospecific aminopeptidase | False | 15 | 760 | 1 | 4 | Release of an N-terminal D-amino acid from a peptide, Xaa!Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-Amino acid amides and methyl esters also are hydrolysed, as is glycine amide | None | None | D-aminopeptidase | |
| 3.4.11.20 | aminopeptidase Ey | False | 1 | 0 | 0 | 4 | Differs from other aminopeptidases in broad specificity for amino acids in the P1 position and the ability to hydrolyse peptides of four or five residues that contain Pro in the P1' position | None | None | None | |
| 3.4.11.21 | aspartyl aminopeptidase | False | 11 | 4525 | 6 | 18 | Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate | None | None | None | |
| 3.4.11.22 | aminopeptidase I | False | 1 | 28 | 5 | 21 | Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates | None | None | aminopeptidase III; aminopeptidase yscI (gene name); leucine aminopeptidase IV; yeast aminopeptidase I | |
| 3.4.11.23 | PepB aminopeptidase | False | 66 | 2217 | 3 | 3 | Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln | None | None | Salmonella enterica serovar Typhimurium peptidase B | |
| 3.4.13.4 | Xaa-Arg dipeptidase | False | 2 | 0 | 1 | 3 | Preferential hydrolysis of Xaa!Arg, Xaa!Lys or Xaa!ornithine dipeptides | None | None | aminoacyl-lysine dipeptidase; N2-(4-amino-butyryl)-L-lysine hydrolase; X-Arg dipeptidase | |
| 3.4.13.5 | Xaa-methyl-His dipeptidase | False | 0 | 10 | 0 | 5 | Hydrolysis of anserine (beta-alanyl!Npi-methyl-L-histidine), carnosine, homocarnosine, glycyl!leucine and other dipeptides with broad specificity | None | None | anserinase; aminoacyl-methylhistidine dipeptidase; acetylhistidine deacetylase; N-acetylhistidine deacetylase; alpha-N-acetyl-L-histidine aminohydrolase; X-methyl-His dipeptidase | |
| 3.4.13.7 | Glu-Glu dipeptidase | True | 0 | 0 | 0 | 1 | Hydrolysis of the Glu!Glu dipeptide | None | None | alpha-glutamyl-glutamate dipeptidase; glutamylglutamic arylamidase | |
| 3.4.13.9 | Xaa-Pro dipeptidase | False | 118 | 7866 | 49 | 27 | Hydrolysis of Xaa!Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro | None | None | prolidase; imidodipeptidase; proline dipeptidase; peptidase D; gamma-peptidase; X-Pro dipeptidase | |
| 3.4.13.12 | Met-Xaa dipeptidase | True | 0 | 0 | 0 | 2 | Hydrolysis of Met!Xaa dipeptides | None | None | methionyl dipeptidase; dipeptidase M; Met-X dipeptidase | |
| 3.4.13.17 | non-stereospecific dipeptidase | True | 0 | 0 | 0 | 3 | Hydrolysis of dipeptides containing either D- or L-amino acids or both | None | None | peptidyl-D-amino acid hydrolase; D-(or L-)aminoacyl-dipeptidase | |
| 3.4.13.18 | cytosol nonspecific dipeptidase | False | 7 | 2654 | 3 | 16 | Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids | None | None | N2-beta-alanylarginine dipeptidase; glycyl-glycine dipeptidase; glycyl-leucine dipeptidase; iminodipeptidase; peptidase A; Pro-X dipeptidase; prolinase; prolyl dipeptidase; prolylglycine dipeptidase; L-prolylglycine dipeptidase; diglycinase; Gly-Leu hydrolase; glycyl-L-leucine dipeptidase; glycyl-L-leucine hydrolase; glycyl-L-leucine peptidase; L-amino-acyl-L-amino-acid hydrolase; glycylleucine peptidase; glycylleucine hydrolase; glycylleucine dipeptide hydrolase; non-specific dipeptidase; human cytosolic non-specific dipeptidase | |
| 3.4.13.19 | membrane dipeptidase | False | 45 | 7388 | 17 | 12 | Hydrolysis of dipeptides | None | None | renal dipeptidase; dehydropeptidase I (DPH I); dipeptidase (ambiguous); aminodipeptidase; dipeptide hydrolase (ambiguous); dipeptidyl hydrolase (ambiguous); nonspecific dipeptidase; glycosyl-phosphatidylinositol-anchored renal dipeptidase; MDP | |
| 3.4.13.20 | beta-Ala-His dipeptidase | False | 3 | 878 | 2 | 5 | Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine | None | None | serum carnosinase | |
| 3.4.13.21 | dipeptidase E | False | 63 | 2894 | 4 | 12 | Dipeptidase E catalyses the hydrolysis of dipeptides Asp!Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides | None | None | aspartyl dipeptidase; peptidase E; PepE gene product (Salmonella typhimurium) | |
| 3.4.14.1 | dipeptidyl-peptidase I | False | 8 | 1042 | 19 | 16 | Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro | None | None | cathepsin C; dipeptidyl aminopeptidase I; dipeptidyl transferase; dipeptide arylamidase I; DAP I | |
| 3.4.14.2 | dipeptidyl-peptidase II | False | 3 | 32 | 3 | 10 | Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides | None | None | dipeptidyl aminopeptidase II; dipeptidyl arylamidase II; carboxytripeptidase; dipeptidyl peptidase II; DAP II; dipeptidyl(amino)peptidase II; dipeptidylarylamidase | |
| 3.4.14.4 | dipeptidyl-peptidase III | False | 8 | 2835 | 17 | 23 | Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides. | None | None | dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; enkephalinase B; red cell angiotensinase | |
| 3.4.14.5 | dipeptidyl-peptidase IV | False | 78 | 5849 | 151 | 35 | Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline | None | None | dipeptidyl aminopeptidase IV; Xaa-Pro-dipeptidyl-aminopeptidase; Gly-Pro naphthylamidase; postproline dipeptidyl aminopeptidase IV; lymphocyte antigen CD26; glycoprotein GP110; dipeptidyl peptidase IV; glycylproline aminopeptidase; X-prolyl dipeptidyl aminopeptidase; pep X; leukocyte antigen CD26; glycylprolyl dipeptidylaminopeptidase; dipeptidyl-peptide hydrolase; glycylprolyl aminopeptidase; dipeptidyl-aminopeptidase IV; DPP IV/CD26; amino acyl-prolyl dipeptidyl aminopeptidase; T cell triggering molecule Tp103; X-PDAP | |
| 3.4.14.6 | dipeptidyl-dipeptidase | True | 0 | 0 | 0 | 2 | Preferential release of dipeptides from a tetrapeptide, e.g. Ala-Gly!Ala-Gly. Acts more slowly on Ala-Ala!Ala-Ala and Gly-Gly!Gly-Gly | None | None | dipeptidyl tetrapeptide hydrolase; dipeptidyl ligase; tetrapeptide dipeptidase | |
| 3.4.14.9 | tripeptidyl-peptidase I | False | 10 | 519 | 2 | 9 | Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity. | None | None | tripeptidyl aminopeptidase; tripeptidyl peptidase | |
| 3.4.14.10 | tripeptidyl-peptidase II | False | 25 | 7381 | 1 | 15 | Release of an N-terminal tripeptide from a polypeptide | None | None | tripeptidyl aminopeptidase; tripeptidyl peptidase; tripeptidyl aminopeptidase II; tripeptidyl peptidase II; TPP | |
| 3.4.14.11 | Xaa-Pro dipeptidyl-peptidase | False | 60 | 3296 | 2 | 15 | Hydrolyses Xaa-Pro! bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro!p-nitroanilide and (sequentially) Tyr-Pro!Phe-Pro!Gly-Pro!Ile | None | None | X-prolyl dipeptidyl aminopeptidase; PepX; X-prolyl dipeptidyl peptidase; X-Pro dipeptidyl-peptidase | |
| 3.4.15.1 | peptidyl-dipeptidase A | False | 13 | 184 | 41 | 30 | Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II | None | None | dipeptidyl carboxypeptidase I; peptidase P; dipeptide hydrolase (ambiguous); peptidyl dipeptidase; angiotensin converting enzyme; kininase II; angiotensin I-converting enzyme; carboxycathepsin; dipeptidyl carboxypeptidase; peptidyl dipeptidase I; peptidyl-dipeptide hydrolase; peptidyldipeptide hydrolase; endothelial cell peptidyl dipeptidase; ACE; peptidyl dipeptidase-4; PDH; peptidyl dipeptide hydrolase; DCP | |
| 3.4.15.4 | peptidyl-dipeptidase B | True | 0 | 0 | 0 | 1 | Release of a C-terminal dipeptide or exceptionally a tripeptide | None | None | dipeptidyl carboxyhydrolase; atriopeptin convertase; atrial di-(tri)peptidyl carboxyhydrolase; peptidyldipeptidase B; atrial dipeptidyl carboxyhydrolase; atrial peptide convertase | |
| 3.4.15.5 | peptidyl-dipeptidase Dcp | False | 2 | 2779 | 2 | 4 | Hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly | None | None | dipeptidyl carboxypeptidase (Dcp); dipeptidyl carboxypeptidase | |
| 3.4.16.2 | lysosomal Pro-Xaa carboxypeptidase | False | 4 | 118 | 1 | 8 | Cleavage of a -Pro!Xaa bond to release a C-terminal amino acid | None | None | angiotensinase C; lysosomal carboxypeptidase C; peptidylprolylamino acid carboxypeptidase; aminoacylproline carboxypeptidase; prolyl carboxypeptidase; carboxypeptidase P; proline-specific carboxypeptidase P; PCP | |
| 3.4.16.4 | serine-type D-Ala-D-Ala carboxypeptidase | False | 109 | 103037 | 193 | 27 | Preferential cleavage: (Ac)2-L-Lys-D-Ala!D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine | None | None | DD-peptidase; D-alanyl-D-alanine-carboxypeptidase; D-alanyl-D-alanine-cleaving-peptidase; D-alanyl-D-alanine-cleaving peptidase; DD-transpeptidase; D-alanine carboxypeptidase; DD-carboxypeptidase; D-alanyl carboxypeptidase | |
| 3.4.16.5 | carboxypeptidase C | False | 59 | 602 | 12 | 25 | Release of a C-terminal amino acid with broad specificity | None | None | carboxypeptidase Y; serine carboxypeptidase I; cathepsin A; lysosomal protective protein; deamidase; lysosomal carboxypeptidase A; phaseolin | |
| 3.4.16.6 | carboxypeptidase D | False | 82 | 702 | 3 | 8 | Preferential release of a C-terminal arginine or lysine residue | None | None | cereal serine carboxypeptidase II; Saccharomyces cerevisiae KEX1 gene product; carboxypeptidase Kex1; gene KEX1 serine carboxypeptidase; KEX1 carboxypeptidase; KEX1 proteinase; KEX1DELTAp; CPDW-II; serine carboxypeptidase (misleading); Phaseolus proteinase | |
| 3.4.17.1 | carboxypeptidase A | False | 8 | 572 | 38 | 32 | Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro | None | None | carboxypolypeptidase; pancreatic carboxypeptidase A; tissue carboxypeptidase A | |
| 3.4.17.2 | carboxypeptidase B | False | 9 | 772 | 45 | 23 | Preferential release of a C-terminal lysine or arginine amino acid | None | None | protaminase; pancreatic carboxypeptidase B; tissue carboxypeptidase B; peptidyl-L-lysine [L-arginine]hydrolase | |
| 3.4.17.3 | lysine carboxypeptidase | False | 4 | 17 | 1 | 10 | Release of a C-terminal basic amino acid, preferentially lysine | None | None | carboxypeptidase N; arginine carboxypeptidase; kininase I; anaphylatoxin inactivator; plasma carboxypeptidase B; creatine kinase conversion factor; bradykinase; kininase Ia; hippuryllysine hydrolase; bradykinin-decomposing enzyme; protaminase; CPase N; creatinine kinase convertase; peptidyl-L-lysine(-L-arginine) hydrolase; CPN | |
| 3.4.17.4 | Gly-Xaa carboxypeptidase | False | 1 | 83 | 0 | 3 | Release of a C-terminal amino acid from a peptide in which glycine is the penultimate amino acid, e.g. Z-Gly!Leu | None | None | glycine carboxypeptidase; carboxypeptidase a; carboxypeptidase S; peptidase alpha; yeast carboxypeptidase; Gly-X carboxypeptidase | |
| 3.4.17.6 | alanine carboxypeptidase | False | 1 | 0 | 0 | 3 | Release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups | None | None | N-benzoyl-L-alanine-amidohydrolase | |
| 3.4.17.8 | muramoylpentapeptide carboxypeptidase | False | 0 | 17 | 1 | 13 | Cleavage of the bond UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-6-carboxy-L-lysyl-D-alanyl!D-alanine | None | None | D-alanine carboxypeptidase I; DD-carboxypeptidase; D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanine-D-alanine-carboxypeptidase; carboxypeptidase D-alanyl-D-alanine; carboxypeptidase I; UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase; D-alanyl-D-alanine peptidase; DD-peptidase; penicillin binding protein 5; PBP5; PdcA; VanY | |
| 3.4.17.10 | carboxypeptidase E | False | 8 | 543 | 0 | 14 | Release of C-terminal arginine or lysine residues from polypeptides | None | None | carboxypeptidase H; enkephalin convertase; cobalt-stimulated chromaffin granule carboxypeptidase; insulin granule-associated carboxypeptidase; enkephalin convertase; membrane-bound carboxypeptidase; carboxypeptidase E; enkephalin-precursor endopeptidase; enkephalin precursor carboxypeptidase; peptidyl-L-lysine(-L-arginine) hydrolase | |
| 3.4.17.11 | glutamate carboxypeptidase | False | 1 | 1331 | 3 | 7 | Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups | None | None | carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase | |
| 3.4.17.12 | carboxypeptidase M | False | 3 | 26 | 1 | 7 | Cleavage of C-terminal arginine or lysine residues from polypeptides | None | None | CPM | |
| 3.4.17.13 | muramoyltetrapeptide carboxypeptidase | False | 9 | 2908 | 11 | 12 | Hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-lysyl!D-alanine | None | None | carboxypeptidase IIW; carboxypeptidase II; lysyl-D-alanine carboxypeptidase; L-lysyl-D-alanine carboxypeptidase; LD-carboxypeptidase | |
| 3.4.17.14 | zinc D-Ala-D-Ala carboxypeptidase | False | 1 | 296 | 0 | 5 | Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl!D-alanine | None | None | Zn2+ G peptidase; D-alanyl-D-alanine hydrolase; D-alanyl-D-alanine-cleaving carboxypeptidase; DD-carboxypeptidase; G enzyme; DD-carboxypeptidase-transpeptidase | |
| 3.4.17.15 | carboxypeptidase A2 | False | 3 | 12 | 2 | 4 | Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues | None | None | CPA2 | |
| 3.4.17.16 | membrane Pro-Xaa carboxypeptidase | True | 0 | 0 | 0 | 3 | Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond | None | None | carboxypeptidase P; microsomal carboxypeptidase; membrane Pro-X carboxypeptidase | |
| 3.4.17.17 | tubulinyl-Tyr carboxypeptidase | False | 7 | 7 | 24 | 7 | Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr | None | None | carboxypeptidase-tubulin; soluble carboxypeptidase; tubulin-tyrosine carboxypeptidase; tubulin carboxypeptidase; tubulinyltyrosine carboxypeptidase; tyrosinotubulin carboxypeptidase; tyrosyltubulin carboxypeptidase; TTCPase; brain I carboxypeptidase; carboxypeptidase 1; CCP1 | |
| 3.4.17.18 | carboxypeptidase T | False | 3 | 222 | 23 | 3 | Releases a C-terminal residue, which may be hydrophobic or positively charged | None | None | CPT (ambiguous) | |
| 3.4.17.19 | carboxypeptidase Taq | False | 4 | 10778 | 4 | 2 | Release of a C-terminal amino acid with broad specificity, except for -Pro | None | None | None | |
| 3.4.17.20 | carboxypeptidase U | False | 4 | 3 | 13 | 11 | Release of C-terminal Arg and Lys from a polypeptide | None | None | arginine carboxypeptidase; carboxypeptidase R; plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes); thrombin-activatable fibrinolysis inhibitor | |
| 3.4.17.21 | glutamate carboxypeptidase II | False | 13 | 234 | 89 | 9 | Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates | None | None | N-acetylated-gamma-linked-acidic dipeptidase (NAALADase); folate hydrolase; prostate-specific membrane antigen; pteroylpoly-gamma-glutamate carboxypeptidase; microsomal gamma-glutamyl carboxypeptidase; pteroylpolyglutamate hydrolase; folylpolyglutamate hydrolase; pteroylpoly-gamma-glutamate hydrolase; pteroylpolygammaglutamyl hydrolase; pteroylpolyglutamic acid hydrolase; PSM antigen; acetylaspartylglutamate dipeptidase; NAALA dipeptidase; rat NAAG peptidase; mGCP; membrane glutamate carboxypeptidase; N-acetylated-alpha-linked-amino dipeptidase; prostrate-specific membrane antigen; N-Acetylated alpha-linked acidic dipeptidase; PSMA | |
| 3.4.17.22 | metallocarboxypeptidase D | False | 6 | 1792 | 1 | 10 | Releases C-terminal Arg and Lys from polypeptides | None | None | carboxypeptidase D (cattle, human, mouse, rat); gp180 (duck) | |
| 3.4.18.1 | cathepsin X | False | 6 | 1192 | 1 | 8 | Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity | None | None | cathepsin B2; cysteine-type carboxypeptidase; cathepsin IV; cathepsin Z; acid carboxypeptidase; lysosomal carboxypeptidase B | |
| 3.4.19.1 | acylaminoacyl-peptidase | False | 10 | 3472 | 16 | 22 | (1) cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide;;(2) internal cleavage of oxidized and glycated proteins | None | None | acylamino-acid-releasing enzyme; N-acylpeptide hydrolase; N-formylmethionine (fMet) aminopeptidase; alpha-N-acylpeptide hydrolase; oxidized protein hydrolase; acylpeptide hydrolase; AARE; AAP; OPH; AAH; APEH; ACPH | |
| 3.4.19.2 | peptidyl-glycinamidase | True | 0 | 0 | 0 | 4 | Cleavage of C-terminal glycinamide from polypeptides | None | None | carboxyamidase; peptidyl carboxy-amidase; peptidyl-aminoacylamidase; carboxamidopeptidase; peptidyl amino acid amide hydrolase | |
| 3.4.19.3 | pyroglutamyl-peptidase I | False | 149 | 7569 | 23 | 32 | Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro | None | None | 5-oxoprolyl-peptidase; pyrase; pyroglutamate aminopeptidase; pyroglutamyl aminopeptidase; L-pyroglutamyl peptide hydrolase; pyrrolidone-carboxyl peptidase; pyrrolidone-carboxylate peptidase; pyrrolidonyl peptidase; L-pyrrolidonecarboxylate peptidase; pyroglutamidase; pyrrolidonecarboxylyl peptidase | |
| 3.4.19.5 | beta-aspartyl-peptidase | False | 21 | 4327 | 26 | 7 | Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide | None | None | beta-aspartyl dipeptidase; beta-aspartyl peptidase; beta-aspartyldipeptidase | |
| 3.4.19.6 | pyroglutamyl-peptidase II | False | 3 | 8 | 0 | 7 | Release of the N-terminal pyroglutamyl group from pGlu!His-Xaa tripeptides and pGlu!His-Xaa-Gly tetrapeptides | None | None | thyroliberinase; pyroglutamyl aminopeptidase II; thyrotropin-releasing factor pyroglutamate aminopeptidase; pyroglutamate aminopeptidase II; pyroglutamyl peptidase II; thyroliberin-hydrolyzing pyroglutamate aminopeptidase; thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase; thyrotropin-releasing hormone-degrading peptidase; TRH aminopeptidase | |
| 3.4.19.7 | N-formylmethionyl-peptidase | True | 0 | 0 | 0 | 1 | Release of an N-terminal, formyl-methionyl residue from a polypeptide | None | None | (fMet)-releasing enzyme; formylmethionine aminopeptidase | |
| 3.4.19.9 | folate gamma-glutamyl hydrolase | False | 10 | 3187 | 6 | 16 | tetrahydropteroyl-(gamma-glutamyl)n + (n-1) H2O = 5,6,7,8-tetrahydrofolate + (n-1) L-glutamate | tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase | None | GGH (gene name); conjugase; folate conjugase; lysosomal gamma-glutamyl carboxypeptidase; gamma-Glu-X carboxypeptidase; pteroyl-poly-gamma-glutamate hydrolase; carboxypeptidase G; folic acid conjugase; poly(gamma-glutamic acid) endohydrolase; polyglutamate hydrolase; poly(glutamic acid) hydrolase II; pteroylpoly-gamma-glutamyl hydrolase; gamma-glutamyl hydrolase | |
| 3.4.19.11 | gamma-D-glutamyl-meso-diaminopimelate peptidase | False | 3 | 505 | 2 | 1 | Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm. It is required that the D-terminal amino and carboxy groups of meso-A2pm are unsubstituted | None | None | endopeptidase I; gamma-D-glutamyldiaminopimelate endopeptidase; gamma-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase; gamma-glutamyl-L-meso-diaminopimelyl endopeptidase; gamma-D-glutamyl-meso-diaminopimelate endopeptidase; gamma-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase; gamma-D-glutamyl-meso-diaminopimelic endopeptidase; gamma-D-glutamyl-meso-D-aminopimelic endopeptidase | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | False | 603 | 155576 | 539 | 27 | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) | None | None | ubiquitin C-terminal hydrolase; yeast ubiquitin hydrolase | |
| 3.4.21.1 | chymotrypsin | False | 19 | 404 | 84 | 37 | Preferential cleavage: Tyr!, Trp!, Phe!, Leu! | None | None | chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin | |
| 3.4.21.2 | chymotrypsin C | False | 4 | 3 | 1 | 5 | Preferential cleavage: Leu!, Tyr!, Phe!, Met!, Trp!, Gln!, Asn! | None | None | None | |
| 3.4.21.3 | metridin | True | 0 | 0 | 0 | 1 | Preferential cleavage: Tyr!, Phe!, Leu!; little action on Trp-! | None | None | Metridium proteinase A; sea anemone protease A; sea anemone proteinase A | |
| 3.4.21.4 | trypsin | False | 80 | 4827 | 691 | 98 | Preferential cleavage: Arg!, Lys! | None | None | alpha-trypsin; beta-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase | |
| 3.4.21.5 | thrombin | False | 7 | 1053 | 483 | 10 | Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B | None | None | fibrinogenase; thrombase; thrombofort; topical; thrombin-C; tropostasin; activated blood-coagulation factor II; blood-coagulation factor IIa; factor IIa; E thrombin; beta-thrombin; gamma-thrombin | |
| 3.4.21.6 | coagulation factor Xa | False | 21 | 685 | 139 | 13 | Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin | None | None | thrombokinase; prothrombase; prothrombinase; activated blood-coagulation factor X; autoprothrombin C; thromboplastin; plasma thromboplastin; factor Xa; activated Stuart-Prower factor; activated factor X | |
| 3.4.21.7 | plasmin | False | 15 | 1997 | 39 | 7 | Preferential cleavage: Lys! > Arg!; higher selectivity than trypsin. Converts fibrin into soluble products | None | None | fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin | |
| 3.4.21.9 | enteropeptidase | False | 4 | 85 | 4 | 7 | Activation of trypsinogen by selective cleavage of Lys6!Ile bond | None | None | enterokinase | |
| 3.4.21.10 | acrosin | False | 8 | 129 | 0 | 49 | Preferential cleavage: Arg!, Lys! | None | None | acrosomal proteinase; acrozonase; alpha-acrosin; beta-acrosin; upsilon-acrosin; acrosomal protease; acrosin amidase | |
| 3.4.21.12 | alpha-lytic endopeptidase | False | 3 | 101 | 46 | 4 | Preferential cleavage: Ala!, Val! in bacterial cell walls, elastin and other proteins | None | None | myxobacter alpha-lytic proteinase; alpha-lytic proteinase; alpha-lytic protease; Mycobacterium sorangium alpha-lytic proteinase; Myxobacter 495 alpha-lytic proteinase; Myxobacter alpha-lytic proteinase | |
| 3.4.21.19 | glutamyl endopeptidase | False | 12 | 121 | 13 | 13 | Preferential cleavage: Glu!, Asp! | None | None | V8 proteinase; endoproteinase Glu-C; staphylococcal serine proteinase | |
| 3.4.21.20 | cathepsin G | False | 3 | 4 | 5 | 8 | Specificity similar to chymotrypsin C | None | None | chymotrypsin-like proteinase; neutral proteinase | |
| 3.4.21.21 | coagulation factor VIIa | False | 7 | 619 | 103 | 5 | Selective cleavage of Arg!Ile bond in factor X to form factor Xa | None | None | blood-coagulation factor VIIa; activated blood coagulation factor VII | |
| 3.4.21.22 | coagulation factor IXa | False | 12 | 1036 | 44 | 3 | Selective cleavage of Arg!Ile bond in factor X to form factor Xa | None | None | activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI | |
| 3.4.21.25 | cucumisin | False | 1 | 264 | 2 | 4 | Hydrolysis of proteins with broad specificity | None | None | euphorbain; solanain; hurain; tabernamontanain | |
| 3.4.21.26 | prolyl oligopeptidase | False | 20 | 10681 | 37 | 53 | Hydrolysis of ---Pro! and to a lesser extent ---Ala! in oligopeptides | None | None | post-proline cleaving enzyme; proline-specific endopeptidase; post-proline endopeptidase; proline endopeptidase; endoprolylpeptidase; prolyl endopeptidase | |
| 3.4.21.27 | coagulation factor XIa | False | 3 | 47 | 107 | 9 | Selective cleavage of Arg!Ala and Arg!Val bonds in factor IX to form factor IXa | None | None | blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent | |
| 3.4.21.32 | brachyurin | False | 9 | 10 | 1 | 10 | Hydrolysis of proteins, with broad specificity for peptide bonds. Native collagen is cleaved about 75% of the length of the molecule from the N-terminus. Low activity on small molecule substrates of both trypsin and chymotrypsin | None | None | Uca pugilator collagenolytic proteinase; crab protease I; crab protease II | |
| 3.4.21.34 | plasma kallikrein | False | 4 | 25 | 15 | 9 | Selective cleavage of some Arg! and Lys! bonds, including Lys!Arg and Arg!Ser in (human) kininogen to release bradykinin | None | None | serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein | |
| 3.4.21.35 | tissue kallikrein | False | 29 | 50 | 9 | 12 | Preferential cleavage of Arg! bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met! or Leu!. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg! bonds [5] | None | None | glandular kallikrein; pancreatic kallikrein; submandibular kallikrein; submaxillary kallikrein; kidney kallikrein; urinary kallikrein; kallikrein; salivary kallikrein; kininogenin; kininogenase; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; depot-padutin; urokallikrein; dilminal D; onokrein P | |
| 3.4.21.36 | pancreatic elastase | False | 9 | 1306 | 123 | 9 | Hydrolysis of proteins, including elastin. Preferential cleavage: Ala! | None | None | pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase | |
| 3.4.21.37 | leukocyte elastase | False | 2 | 2 | 35 | 12 | Hydrolysis of proteins, including elastin. Preferential cleavage Val! > Ala! | None | None | lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; granulocyte elastase | |
| 3.4.21.38 | coagulation factor XIIa | False | 6 | 248 | 14 | 7 | Selective cleavage of Arg!Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa | None | None | Hageman factor (activated); blood-coagulation factor XIIf; activated beta blood-coagulation factor XII; prealbumin activator; Hageman factor beta-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIabeta; prekallikrein activator; kallikreinogen activator | |
| 3.4.21.39 | chymase | False | 9 | 4 | 18 | 11 | Preferential cleavage: Phe! > Tyr! > Trp! > Leu! | None | None | mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase; skeletal muscle (SK) protease | |
| 3.4.21.41 | complement subcomponent C_overbar_1r_ | False | 6 | 1003 | 9 | 5 | Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) | None | None | activated complement C1r; C_overbar_1r_ esterase | |
| 3.4.21.42 | complement subcomponent C_overbar_1s_ | False | 6 | 4 | 9 | 7 | Cleavage of Arg!Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)!Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase | None | None | C1 esterase; activated complement C1s; complement C_overbar_1r_ | |
| 3.4.21.43 | classical-complement-pathway C3/C5 convertase | False | 6 | 442 | 6 | 4 | Selective cleavage of Arg!Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg! bond in complement component C5 alpha-chain to form C5a and C5b | None | None | C3 convertase; C_overbar_42_; C4b,2a; C5 convertase; C_overbar_423_; C4b,2a,3b; C42; C423; complement C.hivin.4.hivin2; complement C3 convertase | |
| 3.4.21.45 | complement factor I | False | 4 | 21 | 2 | 13 | Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage | None | None | complement component C3b inactivator; C3b inactivator; C3b/C4b inactivator; C3bINA; complement C3b/C4b inactivator; complement C4b inactivator; conglutinogen-activating factor C; complement C3b inactivator; factor I; complement C4bi | |
| 3.4.21.46 | complement factor D | False | 5 | 174 | 40 | 7 | Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor | None | None | C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement) | |
| 3.4.21.47 | alternative-complement-pathway C3/C5 convertase | False | 7 | 232 | 22 | 4 | Cleavage of Arg!Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg! bond in complement component C5 alpha-chain to yield C5a and C5b | None | None | complement component C3/C5 convertase (alternative); proenzyme factor B; properdin factor B; C3 proactivator; glycine-rich beta-glycoprotein; heat-labile factor; C3 convertase; C3b,Bb,CVF,Bb,C5 convertase; (C3b)n,Bb; complement C 3(C 5) convertase (amplification); alternative complement pathway C3(C5) convertase; C5 convertase; CVF,Bb; (CVF)-dependent glycine-rich-beta-glucoprotein; cobra venom factor-dependent C3 convertase | |
| 3.4.21.48 | cerevisin | False | 1 | 71 | 0 | 2 | Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt Ac-Tyr-OEt. Does not hydrolyse peptide amides | None | None | yeast proteinase B; proteinase yscB (gene name); baker's yeast proteinase B; brewer's yeast proteinase; peptidase beta | |
| 3.4.21.49 | hypodermin C | False | 1 | 0 | 0 | 2 | Hydrolysis of proteins including native collagen at !Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment | None | None | Hypoderma collagenase | |
| 3.4.21.50 | lysyl endopeptidase | False | 4 | 240 | 5 | 7 | Preferential cleavage: Lys!, including -Lys!Pro- | None | None | Achromobacter proteinase I (also see Comment); Achromobacter lyticus alkaline proteinase I; protease I; achromopeptidase; lysyl bond specific proteinase | |
| 3.4.21.53 | endopeptidase La | False | 191 | 64976 | 96 | 47 | Hydrolysis of proteins in presence of ATP | None | None | ATP-dependent serine proteinase; lon proteinase; protease La; proteinase La; ATP-dependent lon proteinase; ATP-dependent protease La; Escherichia coli proteinase La; Escherichia coli serine proteinase La; gene lon protease; gene lon proteins; PIM1 protease; PIM1 proteinase; serine protease La | |
| 3.4.21.54 | gamma-renin | False | 1 | 0 | 0 | 1 | Cleavage of the Leu!Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide | None | None | None | |
| 3.4.21.55 | venombin AB | False | 1 | 0 | 0 | 3 | Selective cleavage at Arg! bonds in fibrinogen to form fibrin and release fibrinopeptides A and B | None | None | gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afaacytin | |
| 3.4.21.57 | leucyl endopeptidase | True | 0 | 0 | 0 | 2 | Hydrolysis of proteins. Preferential cleavage: Leu! in small molecule substrates | None | None | plant Leu-proteinase; leucine-specific serine proteinase; leucine endopeptidase; spinach serine proteinase (leucine specific); spinach leucine-specific serine proteinase; Leu-proteinase | |
| 3.4.21.59 | tryptase | False | 11 | 11 | 24 | 9 | Preferential cleavage: Arg!, Lys!, but with more restricted specificity than trypsin | None | None | mast cell tryptase; mast cell protease II; skin tryptase; lung tryptase; pituitary tryptase; mast cell neutral proteinase; mast cell serine proteinase II; mast cell proteinase II; mast cell serine proteinase tryptase; rat mast cell protease II; tryptase M | |
| 3.4.21.60 | scutelarin | True | 0 | 0 | 0 | 7 | Selective cleavage of Arg!Thr and Arg!Ile in prothrombin to form thrombin and two inactive fragments | None | None | taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase | |
| 3.4.21.61 | kexin | False | 2 | 70 | 5 | 9 | Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors | None | None | yeast KEX2 protease; proteinase yscF (gene name); prohormone-processing endoprotease; paired-basic endopeptidase; yeast cysteine proteinase F (misleading); andrenorphin-Gly-generating enzyme; endoproteinase Kex2p; gene KEX2 dibasic proteinase; Kex 2p proteinase; Kex2 endopeptidase; Kex2 endoprotease; Kex2 endoproteinase; Kex2 protease; proteinase Kex2p; Kex2-like precursor protein processing endoprotease; prohormone-processing KEX2 proteinase; prohormone-processing proteinase; proprotein convertase; protease KEX2; Kex2 proteinase; Kex2-like endoproteinase | |
| 3.4.21.62 | subtilisin | False | 21 | 5375 | 141 | 48 | Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyses peptide amides | None | None | alcalase; alcalase 0.6L; alcalase 2.5L; ALK-enzyme; bacillopeptidase A; bacillopeptidase B; Bacillus subtilis alkaline proteinase bioprase; bioprase AL 15; bioprase APL 30; colistinase; (see also comments); subtilisin J; subtilisin S41; subtilisin Sendai; subtilisin GX; subtilisin E; subtilisin BL; genenase I; esperase; maxatase; thermoase PC 10; protease XXVII; thermoase; superase; subtilisin DY; subtilopeptidase; SP 266; savinase 8.0L; savinase 4.0T; kazusase; protease VIII; opticlean; Bacillus subtilis alkaline proteinase; protin A 3L; savinase; savinase 16.0L; savinase 32.0 L EX; orientase 10B; protease S | |
| 3.4.21.63 | oryzin | False | 10 | 158 | 4 | 20 | Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyse peptide amides | None | None | Aspergillus alkaline proteinase; aspergillopeptidase B; API 21; aspergillopepsin B; aspergillopepsin F; Aspergillus candidus alkaline proteinase; Aspergillus flavus alkaline proteinase; Aspergillus melleus semi-alkaline proteinase; Aspergillus oryzae alkaline proteinase; Aspergillus parasiticus alkaline proteinase; Aspergillus serine proteinase; Aspergillus sydowi alkaline proteinase; Aspergillus soya alkaline proteinase; Aspergillus melleus alkaline proteinase; Aspergillus sulphureus alkaline proteinase; prozyme; P 5380; kyorinase; seaprose S; semi-alkaline protease; sumizyme MP; prozyme 10; onoprose; onoprose SA; protease P; promelase | |
| 3.4.21.64 | peptidase K | False | 1 | 10 | 247 | 6 | Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyses peptide amides | None | None | Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K | |
| 3.4.21.65 | thermomycolin | False | 1 | 0 | 0 | 1 | Rather nonspecific hydrolysis of proteins. Preferential cleavage: Ala!, Tyr!, Phe! in small molecule substrates | None | None | thermomycolase | |
| 3.4.21.66 | thermitase | False | 1 | 133 | 4 | 7 | Hydrolysis of proteins, including collagen | None | None | thermophilic Streptomyces serine proteinase; Thermoactinomyces vulgaris serine proteinase | |
| 3.4.21.67 | endopeptidase So | True | 0 | 0 | 0 | 2 | Hydrolysis of proteins, but not Bz-Tyr-OEt, Ac-Phe-beta-naphthylester, or Bz-Arg-OEt | None | None | E. coli cytoplasmic proteinase; proteinase So; Escherichia coli serine proteinase So | |
| 3.4.21.68 | t-plasminogen activator | False | 10 | 1319 | 9 | 12 | Specific cleavage of Arg!Val bond in plasminogen to form plasmin | None | None | tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA | |
| 3.4.21.69 | protein C (activated) | False | 11 | 945 | 5 | 5 | Degradation of blood coagulation factors Va and VIIIa | None | None | blood-coagulation factor XIVa; activated blood coagulation factor XIV; activated protein C; autoprothrombin II-A; protein Ca; APC; GSAPC | |
| 3.4.21.70 | pancreatic endopeptidase E | False | 4 | 2 | 0 | 3 | Preferential cleavage: Ala!. Does not hydrolyse elastin | None | None | cholesterol-binding proteinase; proteinase E; cholesterol-binding serine proteinase; pancreatic protease E; pancreatic proteinase E; cholesterol-binding pancreatic proteinase; CBPP; pancreas E proteinase | |
| 3.4.21.71 | pancreatic elastase II | False | 6 | 1259 | 1 | 4 | Preferential cleavage: Leu!, Met! and Phe!. Hydrolyses elastin | None | None | pancreatic elastase 2 | |
| 3.4.21.72 | IgA-specific serine endopeptidase | False | 6 | 480 | 1 | 12 | Cleavage of immunoglobulin A molecules at certain Pro! bonds in the hinge region. No small molecule substrates are known | None | None | IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase | |
| 3.4.21.73 | u-plasminogen activator | False | 9 | 783 | 156 | 7 | Specific cleavage of Arg!Val bond in plasminogen to form plasmin | None | None | urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A | |
| 3.4.21.74 | venombin A | False | 10 | 4 | 2 | 20 | Selective cleavage of Arg! bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme | None | None | alpha-fibrinogenase; habutobin; zinc metalloproteinase Cbfib1.1; zinc metalloproteinase Cbfib1.2; zinc metalloproteinase Cbfib2; ancrod; (see also Comments) | |
| 3.4.21.75 | furin | False | 9 | 762 | 41 | 22 | Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg! bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors | None | None | prohormone convertase; dibasic processing enzyme; PACE; paired basic amino acid cleaving enzyme; paired basic amino acid converting enzyme; serine proteinase PACE; PC1; SPC3; proprotein convertase | |
| 3.4.21.76 | myeloblastin | False | 2 | 2 | 0 | 8 | Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val! | None | None | leukocyte proteinase 3; leukocyte proteinase 4; Wegener's granulomatosis autoantigen; proteinase PR-3; proteinase-3; PMNL proteinase | |
| 3.4.21.77 | semenogelase | False | 3 | 0 | 4 | 5 | Preferential cleavage: -Tyr! | None | None | prostate-specific antigen; alpha-seminoprotein; seminin; P-30 antigen; antigen (human clone HPSA-1 prostate-specific protein moiety reduced); gamma-seminoglycoprotein (human protein moiety reduced); gamma-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced) | |
| 3.4.21.78 | granzyme A | False | 3 | 2 | 2 | 5 | Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg!, -Lys! >> -Phe! in small molecule substrates | None | None | CTLA3; HuTPS; T-cell associated protease 1; cytotoxic T lymphocyte serine protease; TSP-1; T-cell derived serine proteinase | |
| 3.4.21.79 | granzyme B | False | 3 | 1 | 2 | 6 | Preferential cleavage: -Asp! >> -Asn! > -Met!, -Ser! | None | None | CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase | |
| 3.4.21.80 | streptogrisin A | False | 1 | 23 | 0 | 1 | Hydrolysis of proteins with specificity similar to chymotrypsin | None | None | Streptomyces griseus protease A; protease A; proteinase A; Streptomyces griseus proteinase A; Streptomyces griseus serine proteinase 3; Streptomyces griseus serine proteinase A | |
| 3.4.21.81 | streptogrisin B | False | 1 | 102 | 26 | 2 | Hydrolysis of proteins with trypsin-like specificity | None | None | Streptomyces griseus protease B; pronase B; serine proteinase B; Streptomyces griseus proteinase B; Streptomyces griseus proteinase 1; Streptomyces griseus serine proteinase B | |
| 3.4.21.82 | glutamyl endopeptidase II | False | 1 | 4 | 1 | 3 | Preferential cleavage: -Glu! >> -Asp! . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu!Asp- and -Glu!Pro- bonds is slow | None | None | GluSGP | |
| 3.4.21.83 | oligopeptidase B | False | 2 | 4470 | 5 | 16 | Hydrolysis of -Arg!, -Lys! bonds in oligopeptides, even when P1' residue is proline | None | None | protease II; Escherichia coli alkaline proteinase II | |
| 3.4.21.84 | limulus clotting factor _overbar_C_ | False | 2 | 45 | 0 | 6 | Selective cleavage of -Arg103!Ser- and -Ile124!Ile- bonds in limulus clotting factor B to form factor _overbar_B_. Cleavage of -Pro-Arg! bonds in synthetic substrates | None | None | factor C; limulus factor C | |
| 3.4.21.85 | limulus clotting factor _overbar_B_ | False | 2 | 0 | 0 | 1 | Selective cleavage of -Arg98!Ile- bond in limulus proclotting enzyme to form active clotting enzyme | None | None | None | |
| 3.4.21.86 | limulus clotting enzyme | False | 1 | 7 | 0 | 3 | Selective cleavage of -Arg18! and -Arg47! bonds in coagulogen to form coagulin and fragments | None | None | clotting enzyme | |
| 3.4.21.88 | repressor LexA | False | 459 | 31586 | 18 | 20 | Hydrolysis of Ala84!Gly bond in repressor LexA | None | None | LexA repressor | |
| 3.4.21.89 | signal peptidase I | False | 135 | 80393 | 14 | 57 | Cleavage of hydrophobic, N-terminal signal or leader sequences | None | None | leader peptidase I; signal proteinase; Escherichia coli leader peptidase; eukaryotic signal peptidase; eukaryotic signal proteinase; leader peptidase; leader peptide hydrolase; leader proteinase; signal peptidase; pilin leader peptidase; SPC; prokaryotic signal peptidase; prokaryotic leader peptidase; HOSP; prokaryotic signal proteinase; propeptidase; PuIO prepilin peptidase; signal peptide hydrolase; signal peptide peptidase; signalase; bacterial leader peptidase 1 | |
| 3.4.21.90 | togavirin | False | 34 | 0 | 41 | 4 | Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond | None | None | Sindbis virus protease; Sindbis virus core protein; NsP2 proteinase | |
| 3.4.21.91 | flavivirin | False | 61 | 0 | 225 | 14 | Selective hydrolysis of -Xaa-Xaa!Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala | None | None | Yellow fever virus (flavivirus) protease; NS2B-3 proteinase | |
| 3.4.21.92 | endopeptidase Clp | False | 757 | 74099 | 143 | 63 | Hydrolysis of proteins to small peptides in the presence of ATP and Mg2+. alpha-Casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolysed (such as succinyl-Leu-Tyr!NHMec; and Leu-Tyr-Leu!Tyr-Trp, in which cleavage of the -Tyr!Leu- and -Tyr!Trp bonds also occurs) | None | None | endopeptidase Ti; caseinolytic protease; protease Ti; ATP-dependent Clp protease; ClpP; Clp protease | |
| 3.4.21.93 | proprotein convertase 1 | False | 5 | 962 | 3 | 6 | Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds | None | None | prohormone convertase 3; neuroendocrine convertase 1; PC1 | |
| 3.4.21.94 | proprotein convertase 2 | False | 8 | 26 | 0 | 8 | Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds | None | None | neuroendocrine convertase 2; PC2 | |
| 3.4.21.95 | snake venom factor V activator | False | 3 | 0 | 4 | 4 | Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545!Ser-Asn-Asn-Gly bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO2 | None | None | None | |
| 3.4.21.96 | lactocepin | False | 4 | 305 | 0 | 8 | Endopeptidase activity with very broad specificity, although some subsite preferences have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position [1,2]. Best known for its action on caseins, although it has been shown to hydrolyse hemoglobin and oxidized insulin B chain | None | None | CEP; extracellular lactococcal proteinase; lactococcal cell wall-associated proteinase; lactococcal cell envelope-associated proteinase; lactococcal proteinase; PrtP | |
| 3.4.21.97 | assemblin | False | 24 | 1002 | 20 | 20 | Cleaves -Ala!Ser- and -Ala!Ala- bonds in the scaffold protein | None | None | None | |
| 3.4.21.98 | hepacivirin | False | 33 | 182 | 54 | 8 | Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' | None | None | Cpro-2; hepatitis C virus NS3 serine proteinase; NS3-4A serine proteinase complex | |
| 3.4.21.99 | spermosin | False | 1 | 0 | 0 | 1 | Hydrolyses arginyl bonds, preferably with Pro in the P2 position | None | None | None | |
| 3.4.21.100 | sedolisin | False | 1 | 200 | 6 | 6 | Hydrolysis of the B chain of insulin at -Glu13!Ala-, -Leu15!Tyr- and -Phe25!Tyr-, and angiotensin I at -Tyr4!Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe!Phe(NO2)-Arg-Leu. | None | None | Pseudomonas sp. pepstatin-insensitive carboxyl proteinase; pseudomonapepsin; pseudomonalisin; sedolysin | |
| 3.4.21.101 | xanthomonalisin | False | 1 | 67 | 0 | 2 | Cleavage of casein | None | None | Xanthomonas aspartic proteinase; xanthomonapepsin; sedolisin-B | |
| 3.4.21.102 | C-terminal processing peptidase | False | 12 | 6386 | 11 | 27 | The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II | None | None | CtpA gene product (Synechocystis sp.); photosystem II D1 protein processing peptidase; protease Re; tail-specific protease; Tsp protease | |
| 3.4.21.103 | physarolisin | False | 1 | 0 | 0 | 3 | Milk clotting activity. Preferential cleavage of Gly8!Ser in B chain of insulin most rapidly, followed by Leu11!Val, Cys(SO3H)19!Gly and Phe24!Phe. No action on Ac-Phe-Tyr(I)2. | None | None | Dictyostelium discoideum aspartic proteinase; Dictyostelium discoideum aspartic proteinase E; Physarum flavicomum aspartic proteinase; Physarum polycephalum acid proteinase; Physarum aspartic proteinase; physaropepsin | |
| 3.4.21.104 | mannan-binding lectin-associated serine protease-2 | False | 3 | 8 | 2 | 5 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg!Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg!Ala-Leu-Glu-Ile) | None | None | MASP-2; MASP2; MBP-associated serine protease-2; mannose-binding lectin-associated serine protease-2; p100; mannan-binding lectin-associated serine peptidase 2 | |
| 3.4.21.105 | rhomboid protease | False | 109 | 16007 | 46 | 26 | Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains | None | None | None | |
| 3.4.22.1 | cathepsin B | False | 11 | 1210 | 41 | 58 | Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg! bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides | None | None | cathepsin B1 (obsolete); cathepsin II | |
| 3.4.22.2 | papain | False | 1 | 56 | 30 | 2 | Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1' | None | None | papayotin; summetrin; velardon; papaine; Papaya peptidase I | |
| 3.4.22.3 | ficain | False | 0 | 9 | 6 | 7 | Similar to that of papain | None | None | ficin; debricin; higueroxyl delabarre | |
| 3.4.22.6 | chymopapain | False | 1 | 28 | 2 | 2 | Similar to that of papain | None | None | chymopapain A; chymopapain B; chymopapain S | |
| 3.4.22.7 | asclepain | True | 0 | 0 | 0 | 7 | Similar to that of papain | None | None | None | |
| 3.4.22.8 | clostripain | False | 1 | 167 | 0 | 3 | Preferential cleavage: Arg!, including Arg!Pro, but not Lys- | None | None | clostridiopeptidase B; clostridium histolyticum proteinase B; alpha-clostridipain; clostridiopeptidase | |
| 3.4.22.10 | streptopain | False | 7 | 142 | 9 | 2 | Preferential cleavage with hydrophobic residues at P2, P1 and P1' | None | None | Streptococcus peptidase A; streptococcal cysteine proteinase; Streptococcus protease | |
| 3.4.22.14 | actinidain | False | 2 | 72 | 5 | 3 | Similar to that of papain | None | None | actinidin; Actinidia anionic protease; proteinase A2 of Actinidia chinensis | |
| 3.4.22.15 | cathepsin L | False | 21 | 473 | 49 | 55 | Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity | None | None | Aldrichina grahami cysteine proteinase | |
| 3.4.22.16 | cathepsin H | False | 9 | 57 | 5 | 14 | Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg! bonds) as well as an endopeptidase | None | None | cathepsin B3; benzoylarginine-naphthylamide (BANA) hydrolase (obsolete); cathepsin Ba; aleurain; N-benzoylarginine-beta-naphthylamide hydrolase | |
| 3.4.22.24 | cathepsin T | True | 0 | 0 | 0 | 1 | Interconversion of the three forms of tyrosine aminotransferase, EC 2.6.1.5 | None | None | None | |
| 3.4.22.25 | glycyl endopeptidase | False | 1 | 3 | 1 | 1 | Preferential cleavage: Gly!, in proteins and small molecule substrates | None | None | papaya peptidase B; papaya proteinase IV; glycine-specific proteinase; chymopapain; Papaya proteinase 4; PPIV; chymopapain M | |
| 3.4.22.26 | cancer procoagulant | True | 0 | 0 | 0 | 4 | Specific cleavage of Arg!Ile bond in Factor X to form Factor Xa | None | None | None | |
| 3.4.22.27 | cathepsin S | False | 6 | 1307 | 68 | 15 | Similar to cathepsin L, but with much less activity on Z-Phe-Arg!NHMec, and more activity on the Z-Val-Val-Arg! compound | None | None | None | |
| 3.4.22.28 | picornain 3C | False | 89 | 6391 | 166 | 29 | Selective cleavage of Gln!Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly | None | None | picornavirus endopeptidase 3C; poliovirus protease 3C; rhinovirus protease 3C; foot-and-mouth protease 3C; poliovirus proteinase 3C; rhinovirus proteinase 3C; coxsackievirus 3C proteinase; foot-and-mouth-disease virus proteinase 3C; 3C protease; 3C proteinase; cysteine proteinase 3C; hepatitis A virus 3C proteinase; protease 3C; tomato ringspot nepovirus 3C-related protease | |
| 3.4.22.29 | picornain 2A | False | 44 | 6389 | 202 | 20 | Selective cleavage of Tyr!Gly bond in picornavirus polyprotein | None | None | picornavirus endopeptidase 2A; poliovirus protease 2A; rhinovirus protease 2A; 2A protease; 2A proteinase; protease 2A; proteinase 2Apro; picornaviral 2A proteinase; Y-G proteinase 2A; poliovirus proteinase 2A; poliovirus protease 2Apro | |
| 3.4.22.30 | caricain | False | 1 | 0 | 2 | 1 | Hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain | None | None | papaya peptidase A; papaya peptidase II; papaya proteinase; papaya proteinase III; papaya proteinase 3; proteinase omega; papaya proteinase A; chymopapain S; Pp | |
| 3.4.22.31 | ananain | False | 1 | 14 | 6 | 1 | Hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-Arg!NHMec, but broader specificity than fruit bromelain | None | None | stem bromelain; fruit bromelain | |
| 3.4.22.32 | stem bromelain | False | 1 | 1 | 0 | 1 | Broad specificity for cleavage of proteins, but strong preference for Z-Arg-Arg!NHMec amongst small molecule substrates | None | None | bromelain; pineapple stem bromelain | |
| 3.4.22.33 | fruit bromelain | False | 1 | 149 | 0 | 4 | Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg!NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain) | None | None | juice bromelain; ananase; bromelase; bromelin; extranase; pinase; pineapple enzyme; traumanase; fruit bromelain FA2 | |
| 3.4.22.34 | legumain | False | 17 | 1091 | 36 | 40 | Hydrolysis of proteins and small molecule substrates at -Asn!Xaa- bonds | None | None | asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase | |
| 3.4.22.35 | histolysain | False | 2 | 5 | 0 | 2 | Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg! in small molecule substrates including Z-Arg-Arg!NHMec | None | None | histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase | |
| 3.4.22.36 | caspase-1 | False | 11 | 11 | 42 | 16 | Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp! | None | None | interleukin 1beta-converting enzyme; protease VII; protease A; interleukin 1beta precursor proteinase; interleukin 1 converting enzyme; interleukin 1beta-converting endopeptidase; interleukin-1beta convertase; interleukin-1beta converting enzyme; interleukin-1beta precursor proteinase; prointerleukin 1beta protease; precursor interleukin-1beta converting enzyme; pro-interleukin 1beta proteinase; ICE | |
| 3.4.22.37 | gingipain R | False | 4 | 108 | 5 | 1 | Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 | None | None | Arg-gingipain; gingipain-1; argingipain; Arg-gingivain-55 proteinase; Arg-gingivain-70 proteinase; Arg-gingivain-75 proteinase; arginine-specific cysteine protease; arginine-specific gingipain; arginine-specific gingivain; RGP-1; RGP | |
| 3.4.22.38 | cathepsin K | False | 10 | 685 | 73 | 13 | Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met Phe, and not Arg | None | None | cathepsin O and cathepsin X (both misleading, having been used for other enzymes); cathepsin O2 | |
| 3.4.22.39 | adenain | False | 26 | 335 | 6 | 2 | Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly!Xaa- and -Yaa-Xaa-Gly-Xaa!Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid) | None | None | None | |
| 3.4.22.40 | bleomycin hydrolase | False | 18 | 3085 | 10 | 13 | Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred [1] | None | None | aminopeptidase C (Lactococcus lactis) [4] | |
| 3.4.22.41 | cathepsin F | False | 3 | 38 | 1 | 12 | The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L | None | None | None | |
| 3.4.22.42 | cathepsin O | False | 2 | 7 | 0 | 6 | The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec | None | None | None | |
| 3.4.22.43 | cathepsin V | False | 2 | 8 | 24 | 2 | The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) | None | None | Cathepsin L2; cathepsin U | |
| 3.4.22.44 | nuclear-inclusion-a endopeptidase | False | 38 | 15 | 1 | 10 | Hydrolyses glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln!(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. | None | None | potyvirus NIa protease | |
| 3.4.22.45 | helper-component proteinase | False | 62 | 1 | 1 | 20 | Hydrolyses a Gly!Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly!Gly, in the processing of the potyviral polyprotein | None | None | HC-Pro | |
| 3.4.22.46 | L-peptidase | False | 12 | 0 | 5 | 5 | Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys!Gly bond, but then cleaves host cell <a "target = "new" href="http://www.chem.qmul.ac.uk/iubmb/misc/trans.html">initiation factor eIF-4G</a> at bonds -Gly!Arg- and -Lys!Arg- | None | None | None | |
| 3.4.22.47 | gingipain K | False | 4 | 54 | 5 | 1 | Endopeptidase with strict specificity for lysyl bonds | None | None | Lys-gingipain; PrtP proteinase | |
| 3.4.22.48 | staphopain | False | 8 | 36 | 0 | 3 | Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate | None | None | staphylopain | |
| 3.4.22.49 | separase | False | 7 | 3747 | 4 | 21 | All bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage | None | None | separin | |
| 3.4.22.50 | V-cath endopeptidase | False | 18 | 126 | 0 | 4 | Endopeptidase of broad specificity, hydrolysing substrates of both cathepsin L and cathepsin B | None | None | AcNPV protease; BmNPV protease; NPV protease; baculovirus cathepsin; nucleopolyhedrosis virus protease; viral cathepsin | |
| 3.4.22.51 | cruzipain | False | 1 | 4 | 20 | 5 | Broad endopeptidase specificity similar to that of cathepsin L | None | None | congopain; cruzain; evansain; trypanopain | |
| 3.4.22.52 | calpain-1 | False | 9 | 1146 | 15 | 24 | Broad endopeptidase specificity | None | None | mu-calpain; calcium-activated neutral protease I | |
| 3.4.22.53 | calpain-2 | False | 11 | 1002 | 7 | 20 | Broad endopeptidase specificity | None | None | calcium-activated neutral protease II; m-calpain; milli-calpain | |
| 3.4.23.1 | pepsin A | False | 22 | 1264 | 18 | 31 | Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1!Val, Gln4!His, Glu13!Ala, Ala14!Leu, Leu15!Tyr, Tyr16!Leu, Gly23!Phe, Phe24!Phe and Phe25!Tyr bonds in the B chain of insulin | None | None | pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D | |
| 3.4.23.2 | pepsin B | False | 3 | 3 | 0 | 6 | Degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than that of pepsin A; does not cleave at Phe1-Val, Gln4-His or Gly23-Phe | None | None | parapepsin I; pig gelatinase | |
| 3.4.23.3 | gastricsin | False | 11 | 517 | 2 | 10 | More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin | None | None | pepsin C; pig parapepsin II; parapepsin II | |
| 3.4.23.4 | chymosin | False | 5 | 24 | 9 | 18 | Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105!Met-Ala bond in kappa-chain of casein | None | None | rennin (but this should be avoided since it leads to confusion with renin) | |
| 3.4.23.5 | cathepsin D | False | 11 | 1311 | 10 | 42 | Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin | None | None | None | |
| 3.4.23.12 | nepenthesin | False | 4 | 309 | 0 | 14 | Similar to pepsin, but also cleaves on either side of Asp and at Lys!Arg | None | None | Nepenthes aspartic proteinase; Nepenthes acid proteinase; nepenthacin; nepenthasin; aspartyl endopeptidase | |
| 3.4.23.15 | renin | False | 12 | 945 | 93 | 14 | Cleavage of Leu! bond in angiotensinogen to generate angiotensin I | None | None | angiotensin-forming enzyme; angiotensinogenase | |
| 3.4.23.16 | HIV-1 retropepsin | False | 51 | 131 | 602 | 1 | Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro | None | None | human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease | |
| 3.4.23.17 | pro-opiomelanocortin converting enzyme | True | 0 | 0 | 0 | 4 | Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side | None | None | prohormone converting enzyme; pro-opiomelanocortin-converting enzyme; proopiomelanocortin proteinase; PCE | |
| 3.4.23.18 | aspergillopepsin I | False | 15 | 138 | 2 | 12 | Hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk | None | None | Aspergillus acid protease; Aspergillus acid proteinase; Aspergillus aspartic proteinase; Aspergillus awamori acid proteinase; Aspergillus carboxyl proteinase; (see also Comments); carboxyl proteinase; Aspergillus kawachii aspartic proteinase; Aspergillus saitoi acid proteinase; pepsin-type aspartic proteinase; Aspergillus niger acid proteinase; sumizyme AP; proctase P; denapsin; denapsin XP 271; proctase | |
| 3.4.23.19 | aspergillopepsin II | False | 1 | 13 | 2 | 1 | Preferential cleavage in B chain of insulin: Asn3!Gln, Gly13!Ala, Tyr26!Thr | None | None | proteinase A; proctase A; Aspergillus niger var. macrosporus aspartic proteinase | |
| 3.4.23.20 | penicillopepsin | False | 6 | 385 | 14 | 9 | Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20!Glu in the B chain of insulin. Clots milk, and activates trypsinogen | None | None | peptidase A; Penicillium janthinellum aspartic proteinase; acid protease A; Penicillium citrinum acid proteinase; Penicillium cyclopium acid proteinase; Penicillium expansum acid proteinase; Penicillium janthinellum acid proteinase; Penicillium expansum aspartic proteinase; Penicillium aspartic proteinase; Penicillium caseicolum aspartic proteinase; Penicillium roqueforti acid proteinase; Penicillium duponti aspartic proteinase; Penicillium citrinum aspartic proteinase | |
| 3.4.23.21 | rhizopuspepsin | False | 7 | 405 | 1 | 5 | Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave Gln4-His, but does cleave His10!Leu and Val12!Glu in B chain of insulin | None | None | Rhizopus aspartic proteinase; neurase; Rhizopus acid protease; Rhizopus acid proteinase | |
| 3.4.23.22 | endothiapepsin | False | 1 | 0 | 833 | 2 | Hydrolysis of proteins with specificity similar to that of pepsin A; prefers hydrophobic residues at P1 and P1', but does not cleave Ala14-Leu in the B chain of insulin or Z-Glu-Tyr. Clots milk | None | None | Endothia aspartic proteinase; Endothia acid proteinase; Endothia parasitica acid proteinase; Endothia parasitica aspartic proteinase | |
| 3.4.23.23 | mucorpepsin | False | 3 | 0 | 7 | 15 | Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen | None | None | Mucor rennin; Mucor aspartic proteinase; Mucor acid proteinase; Mucor acid protease; Mucor miehei aspartic proteinase; Mucor miehei aspartic protease; Mucor pusillus emporase; Fromase 100; Mucor pusillus rennin; Fromase 46TL; Mucor miehei rennin | |
| 3.4.23.24 | candidapepsin | False | 24 | 376 | 15 | 10 | Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin | None | None | Candida albicans aspartic proteinase; Candida albicans carboxyl proteinase; Candida albicans secretory acid proteinase; Candida olea acid proteinase; Candida aspartic proteinase; Candida olea aspartic proteinase | |
| 3.4.23.25 | saccharopepsin | False | 5 | 97 | 11 | 4 | Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg | None | None | yeast endopeptidase A; Saccharomyces aspartic proteinase; aspartic proteinase yscA (gene name); proteinase A; proteinase yscA (gene name); yeast proteinase A; Saccharomyces cerevisiae aspartic proteinase A; PRA | |
| 3.4.23.26 | rhodotorulapepsin | True | 0 | 0 | 0 | 4 | Specificity similar to that of pepsin A. Cleaves Z-Lys!Ala-Ala-Ala and activates trypsinogen | None | None | Rhodotorula aspartic proteinase; Cladosporium acid protease; Cladosporium acid proteinase; Paecilomyces proteinase; Cladosporium aspartic proteinase; Paecilomyces proteinase; Rhodotorula glutinis aspartic proteinase; Rhodotorula glutinis acid proteinase; Rhodotorula glutinis aspartic proteinase II; Rhodotorula acid proteinase | |
| 3.4.23.28 | acrocylindropepsin | False | 0 | 7 | 0 | 1 | Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6!Cys(SO3H), Glu21!Arg and Asn3!Gln, although not Gln4-His | None | None | Acrocylindrium proteinase; Acrocylindrium acid proteinase | |
| 3.4.23.29 | polyporopepsin | False | 1 | 3 | 1 | 1 | Milk clotting activity, broad specificity, but fails to cleave Leu15-Tyr or Tyr16-Leu of insulin B chain | None | None | Polyporus aspartic proteinase; Irpex lacteus aspartic proteinase; Irpex lacteus carboxyl proteinase B | |
| 3.4.23.30 | pycnoporopepsin | True | 0 | 0 | 0 | 2 | Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala14!Leu, Tyr16!Leu, and Phe24!Phe | None | None | proteinase Ia; Pycnoporus coccineus aspartic proteinase; Trametes acid proteinase | |
| 3.4.23.31 | scytalidopepsin A | True | 0 | 0 | 0 | 1 | Hydrolysis of proteins with specificity similar to that of pepsin A, but also cleaves Cys(SO3H)7!Gly and Leu17!Val in the B chain of insulin | None | None | Scytalidium aspartic proteinase A; Scytalidium lignicolum aspartic proteinase; Scytalidium lignicolum aspartic proteinase A-2; Scytalidium lignicolum aspartic proteinase A-I; Scytalidium lignicolum aspartic proteinase C; Scytalidium lignicolum carboxyl proteinase; Scytalidium lignicolum acid proteinase | |
| 3.4.23.32 | scytalidopepsin B | False | 1 | 0 | 4 | 3 | Hydrolysis of proteins with broad specificity, cleaving Phe24!Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin | None | None | Scytalidium aspartic proteinase B; Ganoderma lucidum carboxyl proteinase; Ganoderma lucidum aspartic proteinase; Scytalidium lignicolum aspartic proteinase B; SLB | |
| 3.4.23.34 | cathepsin E | False | 8 | 704 | 1 | 7 | Similar to cathepsin D, but slightly broader specificity | None | None | slow-moving proteinase; erythrocyte membrane aspartic proteinase; SMP; EMAP; non-pepsin proteinase; cathepsin D-like acid proteinase; cathepsin E-like acid proteinase; cathepsin D-type proteinase | |
| 3.4.23.35 | barrierpepsin | False | 1 | 2 | 0 | 1 | Selective cleavage of -Leu6!Lys- bond in the pheromone alpha-mating factor | None | None | barrier proteinase; Bar proteinase | |
| 3.4.23.36 | signal peptidase II | False | 421 | 43447 | 4 | 16 | Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa!(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains | None | None | premurein-leader peptidase; prolipoprotein signal peptidase; leader peptidase II; premurein leader proteinase | |
| 3.4.23.38 | plasmepsin I | False | 2 | 1 | 2 | 1 | Hydrolysis of the -Phe33!Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule | None | None | aspartic hemoglobinase I; PFAPG; malaria aspartic hemoglobinase | |
| 3.4.23.39 | plasmepsin II | False | 6 | 1 | 29 | 2 | Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr [3] | None | None | aspartic hemoglobinase II; PFAPD | |
| 3.4.23.40 | phytepsin | False | 1 | 73 | 1 | 21 | Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe!Asp- and -Asp!Asp- bonds in 2S albumin from plant seeds | None | None | None | |
| 3.4.23.41 | yapsin 1 | False | 2 | 4 | 0 | 5 | Hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions | None | None | yeast aspartic protease 3; Yap3 gene product (Saccharomyces cerevisiae) | |
| 3.4.23.42 | thermopsin | False | 1 | 44 | 0 | 3 | Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1' | None | None | None | |
| 3.4.23.43 | prepilin peptidase | False | 24 | 14857 | 0 | 21 | Typically cleaves a -Gly!Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine | None | None | None | |
| 3.4.23.44 | nodavirus endopeptidase | False | 5 | 22 | 7 | 6 | Hydrolysis of an asparaginyl bond involved in the maturation of the structural protein of the virus, typically -Asn!Ala- or -Asn!Phe- | None | None | Black Beetle virus endopeptidase; Flock House virus endopeptidase | |
| 3.4.23.45 | memapsin 1 | False | 3 | 9 | 19 | 4 | Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein | None | None | beta-secretase; beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2); ASP1; Down region aspartic protease | |
| 3.4.23.46 | memapsin 2 | False | 5 | 1005 | 425 | 7 | Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein | None | None | beta-secretase; beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) | |
| 3.4.23.47 | HIV-2 retropepsin | False | 12 | 2 | 5 | 1 | Endopeptidase for which the P1 residue is preferably hydrophobic | None | None | None | |
| 3.4.23.48 | plasminogen activator Pla | False | 1 | 102 | 4 | 5 | Converts human Glu-plasminogen to plasmin by cleaving the Arg560!Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins | None | None | None | |
| 3.4.24.1 | atrolysin A | False | 1 | 4 | 0 | 4 | Cleavage of Asn3!Gln, His5!Leu, His10!Leu, Ala14!Leu and Tyr16!Leu in insulin B chain; removes C-terminal Leu from small peptides | None | None | Crotalus atrox metalloendopeptidase a; hemorrhagic toxin a; Crotalus atrox alpha-proteinase; Crotalus atrox proteinase; bothropasin | |
| 3.4.24.3 | microbial collagenase | False | 10 | 2013 | 20 | 23 | Digestion of native collagen in the triple helical region at !Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3' | None | None | Clostridium histolyticum collagenase; clostridiopeptidase A; collagenase A; collagenase I; Achromobacter iophagus collagenase; collagenase; aspergillopeptidase C; nucleolysin; azocollase; metallocollagenase; soycollagestin; Clostridium histolyticum proteinase A; clostridiopeptidase II; MMP-8; clostridiopeptidase I; collagen peptidase; collagen protease; collagenase MMP-1; metalloproteinase-1; kollaza; matrix metalloproteinase-1; MMP-1; matrix metalloproteinase-8; matirx metalloproteinase-18; interstitial collagenase | |
| 3.4.24.6 | leucolysin | False | 0 | 1 | 0 | 2 | Cleavage of Phe1!Val, His5!Leu, Ala14!Leu, Gly20!Glu, Gly23!Phe and Phe24!Phe bonds in insulin B chain as well as N-blocked dipeptides | None | None | Leucostoma neutral proteinase; Leucostoma peptidase A | |
| 3.4.24.7 | interstitial collagenase | False | 10 | 1186 | 16 | 11 | Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue | None | None | vertebrate collagenase; matrix metalloproteinase 1 | |
| 3.4.24.11 | neprilysin | False | 13 | 1438 | 19 | 14 | Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' | None | None | neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metalloendopeptidase; kidney-brush-border neutral endopeptidase; kidney-brush-border neutral proteinase; CALLA glycoprotein; CALLA; common acute lymphoblastic leukemia antigen; CALLA glycoproteins; common acute lymphoblastic leukemia-associated antigens; neutral metallendopeptidase; NEP; neutral endopeptidase 24.11; CD10; acute lymphoblastic leukemia antigen | |
| 3.4.24.12 | envelysin | False | 2 | 21 | 0 | 5 | Hydrolysis of proteins of the fertilization envelope and dimethylcasein | None | None | sea-urchin-hatching proteinase; hatching enzyme; chorionase; chorion-digesting proteinase; chymostrypsin; sea urchin embryo hatching enzyme | |
| 3.4.24.13 | IgA-specific metalloendopeptidase | False | 4 | 603 | 3 | 34 | Cleavage of Pro!Thr bond in the hinge region of the heavy chain of human IgA | None | None | immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase | |
| 3.4.24.14 | procollagen N-endopeptidase | False | 3 | 10 | 0 | 9 | Cleaves the N-propeptide of collagen chain alpha1(I) at Pro!Gln and of alpha1(II) and alpha2(I) at Ala!Gln | None | None | procollagen N-terminal peptidase; procollagen aminopeptidase; aminoprocollagen peptidase; aminoterminal procollagen peptidase; procollagen aminoterminal protease; procollagen N-terminal proteinase; type I/II procollagen N-proteinase; type III procollagen | |
| 3.4.24.15 | thimet oligopeptidase | False | 6 | 933 | 2 | 14 | Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues | None | None | Pz-peptidase; soluble metalloendopeptidase; endo-oligopeptidase A; tissue-endopeptidase degrading collagenase-synthetic-substrate | |
| 3.4.24.16 | neurolysin | False | 7 | 842 | 10 | 9 | Preferential cleavage in neurotensin: Pro10!Tyr | None | None | neurotensin endopeptidase; endopeptidase 24.16; endo-oligopeptidase B (proline-endopeptidase) | |
| 3.4.24.17 | stromelysin 1 | False | 6 | 192 | 44 | 6 | Preferential cleavage where P1', P2' and P3' are hydrophobic residues | None | None | matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein | |
| 3.4.24.18 | meprin A | False | 3 | 6 | 5 | 5 | Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues | None | None | endopeptidase-2; meprin-a; meprin; N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase; PABA-peptide hydrolase; PPH | |
| 3.4.24.19 | procollagen C-endopeptidase | False | 2 | 11 | 8 | 9 | Cleavage of the C-terminal propeptide at Ala!Asp in type I and II procollagens and at Arg!Asp in type III | None | None | procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase | |
| 3.4.24.20 | peptidyl-Lys metalloendopeptidase | False | 3 | 50 | 4 | 5 | Preferential cleavage in proteins: -Xaa!Lys- (in which Xaa may be Pro) | None | None | Armillaria mellea neutral proteinase; peptidyllysine metalloproteinase | |
| 3.4.24.21 | astacin | False | 4 | 19 | 11 | 21 | Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2' | None | None | Astacus proteinase; crayfish small-molecule proteinase | |
| 3.4.24.22 | stromelysin 2 | False | 3 | 4 | 3 | 3 | Similar to stromelysin 1, but action on collagen types III, IV and V is weak | None | None | matrix metalloproteinase 10; transin 2; proteoglycanase 2 | |
| 3.4.24.23 | matrilysin | False | 4 | 20 | 16 | 7 | Cleavage of Ala14!Leu and Tyr16!Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I) | None | None | matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP | |
| 3.4.24.24 | gelatinase A | False | 6 | 1165 | 14 | 14 | Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly!Ile-Ala-Gly-Gln | None | None | 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous) | |
| 3.4.24.25 | vibriolysin | False | 1 | 44 | 3 | 5 | Preferential cleavage of bonds with bulky hydrophobic groups in P2 and P1'. Phe at P1' is the most favoured residue, which distinguished this enzyme from thermolysin | None | None | Aeromonas proteolytica neutral proteinase; aeromonolysin | |
| 3.4.24.26 | pseudolysin | False | 2 | 18 | 4 | 6 | Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects | None | None | Pseudomonas elastase; Pseudomonas aeruginosa neutral metalloproteinase | |
| 3.4.24.27 | thermolysin | False | 5 | 39 | 220 | 11 | Preferential cleavage: !Leu > !Phe | None | None | Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN | |
| 3.4.24.28 | bacillolysin | False | 10 | 127 | 1 | 12 | Similar, but not identical, to that of thermolysin | None | None | Bacillus metalloendopeptidase; Bacillus subtilis neutral proteinase; anilozyme P 10; Bacillus metalloproteinase; Bacillus neutral proteinase; megateriopeptidase | |
| 3.4.24.29 | aureolysin | False | 1 | 24 | 6 | 2 | Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus | None | None | Staphylococcus aureus neutral proteinase; Staphylococcus aureus neutral protease | |
| 3.4.24.30 | coccolysin | False | 1 | 3 | 0 | 3 | Preferential cleavage: !Leu, !Phe, !Tyr, !Ala | None | None | Streptococcus thermophilus intracellular proteinase; EM 19000 | |
| 3.4.24.31 | mycolysin | False | 1 | 1 | 0 | 3 | Preferential cleavage of bonds with hydrophobic residues in P1' | None | None | pronase component; Streptomyces griseus neutral proteinase; actinase E; SGNPI | |
| 3.4.24.32 | beta-lytic metalloendopeptidase | False | 2 | 7 | 0 | 4 | Cleavage of N-acetylmuramoyl!Ala, and of the insulin B chain at Gly23!Phe > Val18!Cya | None | None | Myxobacter beta-lytic proteinase; achromopeptidase component; beta-lytic metalloproteinase; beta-lytic protease; Myxobacterium sorangium beta-lytic proteinase; Myxobacter495 beta-lytic proteinase | |
| 3.4.24.33 | peptidyl-Asp metalloendopeptidase | False | 5 | 11 | 0 | 2 | Cleavage of Xaa!Asp, Xaa!Glu and Xaa!cysteic acid bonds | None | None | endoproteinase Asp-N; peptidyl-Asp metalloproteinase | |
| 3.4.24.34 | neutrophil collagenase | False | 3 | 4 | 24 | 3 | Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I | None | None | matrix metalloproteinase 8; PMNL collagenase; MMP-8 | |
| 3.4.24.35 | gelatinase B | False | 6 | 1135 | 29 | 11 | Cleavage of gelatin types I and V and collagen types IV and V | None | None | 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV (ambiguous); collagenase type IV (ambiguous); gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase (ambiguous) | |
| 3.4.24.36 | leishmanolysin | False | 8 | 557 | 1 | 13 | Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr!Leu-Lys-Lys- | None | None | promastigote surface endopeptidase; glycoprotein gp63; Leishmania metalloproteinase; surface acid proteinase; promastigote surface protease | |
| 3.4.24.37 | saccharolysin | False | 1 | 147 | 0 | 3 | Cleavage of Pro!Phe and Ala!Ala bonds | None | None | proteinase yscD (gene name) (gene name); yeast cysteine proteinase D (Misleading); Saccharomyces cerevisiae proteinase yscD (gene name) | |
| 3.4.24.38 | gametolysin | False | 1 | 1 | 0 | 1 | Cleavage of the proline- and hydroxyproline-rich proteins of the Chlamydomonas cell wall; also cleaves azocasein, gelatin and Leu-Trp-Met!Arg-Phe-Ala | None | None | autolysin; Chlamydomonas cell wall degrading protease; lysin; Chlamydomonas reinhardtii metalloproteinase; gamete lytic enzyme; gamete autolysin | |
| 3.4.24.39 | deuterolysin | False | 59 | 1892 | 4 | 15 | Preferential cleavage of bonds with hydrophobic residues in P1', also Asn3!Gln and Gly8!Ser bonds in insulin B chain | None | None | Penicillium roqueforti protease II; microbial neutral proteinase II; acid metalloproteinase; neutral proteinase II; Penicillium roqueforti metalloproteinase | |
| 3.4.24.40 | serralysin | False | 12 | 950 | 13 | 16 | Preferential cleavage of bonds with hydrophobic residues in P1' | None | None | Pseudomonas aeruginosa alkaline proteinase; Escherichia freundii proteinase; Serratia marcescens extracellular proteinase; Serratia marcescens metalloproteinase; Pseudomonas aeruginosa alk. protease; Serratia marcescens metalloprotease | |
| 3.4.24.41 | atrolysin B | False | 1 | 1 | 0 | 1 | Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves !Ser bonds in glucagon | None | None | Crotalus atrox metalloendopeptidase b; hemorrhagic toxin b; Ht-b | |
| 3.4.24.42 | atrolysin C | False | 2 | 0 | 3 | 3 | Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 | None | None | Crotalus atrox metalloendopeptidase c; hemorrhagic toxin c and d | |
| 3.4.24.43 | atroxase | False | 1 | 0 | 0 | 1 | Cleavage of His5!Leu, Ser9!His, His10!Leu, Ala14!Leu and Tyr16!Leu of insulin B chain | None | None | None | |
| 3.4.24.44 | atrolysin E | False | 1 | 0 | 4 | 1 | Cleavage of Asn3!Gln, Ser9!His and Ala14!Leu bonds in insulin B chain and Tyr14!Gln and Thr8!Ser in A chain. Cleaves type IV collagen at Ala73!Gln in alpha1(IV) and at Gly7!Leu in alpha2(IV) | None | None | Crotalus atrox metalloendopeptidase e; hemorrhagic toxin e | |
| 3.4.24.45 | atrolysin F | True | 0 | 0 | 0 | 1 | Cleavage of Val2!Asn, Gln4!His, Leu6!Cys, His10!Leu, Ala14!Leu and Tyr16!Leu bonds in insulin B chain | None | None | Crotalus atrox metalloendopeptidase; hemorrhagic toxin f; Crotalus atrox metalloendopeptidase f | |
| 3.4.24.46 | adamalysin | False | 1 | 1 | 4 | 2 | Cleavage of Phe1!Val, His5!Leu, His10!Leu, Ala14!Leu, Leu15!Tyr, and Tyr16!Leu of insulin B chain | None | None | Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II | |
| 3.4.24.47 | horrilysin | True | 0 | 0 | 0 | 1 | Cleavage of only the single bond Ala14!Leu in the insulin B chain, Ser12!Leu in the A chain, and Ile!Gly, Pro!Ala, and Ser!Trp in melittin | None | None | Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase | |
| 3.4.24.48 | ruberlysin | False | 1 | 0 | 0 | 1 | Cleavage of His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe bonds in the B chain of insulin; His!Pro, Pro!Phe, and Trp!Ser of angiotensin I; and Gly!Phe of Met enkephalin | None | None | Crotalus ruber metalloendopeptidase II; hemorrhagic toxin II | |
| 3.4.24.49 | bothropasin | False | 1 | 3 | 1 | 2 | Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Phe24!Phe in insulin B chain | None | None | Bothrops jararaca venom metalloproteinase | |
| 3.4.24.50 | bothrolysin | False | 1 | 0 | 0 | 1 | Cleavage of Gln4!His, Ser9!His and Ala14!Leu of insulin B chain and Pro!Phe of angiotensin I | None | None | Bothrops metalloendopeptidase J; J protease | |
| 3.4.24.51 | ophiolysin | True | 0 | 0 | 0 | 1 | Cleavage of Asn3!Gln, Gln4!His, His10!Leu, Ala14!Leu, and Tyr16!Leu in insulin B chain | None | None | Ophiophagus metalloendopeptidase | |
| 3.4.24.52 | trimerelysin I | False | 0 | 7 | 0 | 1 | Cleavage of only two bonds His10!Leu and Ala14!Leu in the insulin B chain | None | None | Trimeresurus metalloendopeptidase I; hemorrhagic proteinase HR1A; hemorrhagic metalloproteinase HR1A; metalloproteinase HR1A | |
| 3.4.24.53 | trimerelysin II | False | 2 | 0 | 2 | 1 | Cleavage of Asn3!Gln, His10!Leu and Ala14!Leu in the insulin B chain, and the bond Z-Gly-Pro!Leu-Gly-Pro in a small molecule substrate of microbial collagenase | None | None | Trimeresurus metalloendopeptidase II; proteinase H2; H2-proteinase | |
| 3.4.24.54 | mucrolysin | True | 0 | 0 | 0 | 1 | Cleavage of Ser9!His, His10!Leu, Ala14!Leu, Leu15!Tyr and Tyr16!Leu bonds in insulin B chain | None | None | Trimeresurus metalloendopeptidase A; mucrotoxin A | |
| 3.4.24.55 | pitrilysin | False | 6 | 5163 | 1 | 3 | Preferential cleavage of -Tyr16! Leu- and -Phe25! Tyr-bonds of oxidized insulin B chain. Also acts on other substrates of less than 7 kDa such as insulin and glucagon | None | None | Escherichia coli protease III; protease Pi; proteinase Pi; PTR; Escherichia coli metalloproteinase Pi | |
| 3.4.24.56 | insulysin | False | 5 | 409 | 65 | 12 | Degradation of insulin, glucagon and other polypeptides. No action on proteins | None | None | insulinase; insulin-degrading enzyme; insulin protease; insulin proteinase; insulin-degrading neutral proteinase; insulin-specific protease; insulin-glucagon protease; metalloinsulinase; IDE | |
| 3.4.24.57 | O-sialoglycoprotein endopeptidase | False | 0 | 130 | 6 | 5 | Hydrolysis of O-sialoglycoproteins; cleaves -Arg31!Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated | None | None | glycoprotease; glycophorin A proteinase; glycoproteinase; sialoglycoprotease; sialoglycoproteinase | |
| 3.4.24.58 | russellysin | False | 3 | 1 | 1 | 3 | Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg! bonds. Has no action on insulin B chain | None | None | Russell's viper venom factor X activator; RVV-X; blood-coagulation factor X activating enzyme; metalloproteinase RVV-x; Vipera russelli proteinase; Russell's viper blood coagulation factor X activator; RVV-V | |
| 3.4.24.59 | mitochondrial intermediate peptidase | False | 44 | 1701 | 0 | 8 | Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion | None | None | mitochondrial intermediate precursor-processing proteinase; MIP | |
| 3.4.24.60 | dactylysin | True | 0 | 0 | 0 | 2 | Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe!Phe- and -Phe!Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively | None | None | peptide hormone inactivating endopeptidase; PHIE | |
| 3.4.24.61 | nardilysin | False | 5 | 31 | 0 | 3 | Hydrolysis of polypeptides, preferably at -Xaa!Arg-Lys-, and less commonly at -Arg!Arg-Xaa-, in which Xaa is not Arg or Lys | None | None | N-arginine dibasic convertase; NRD-convertase | |
| 3.4.24.62 | magnolysin | True | 0 | 0 | 0 | 2 | Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg!Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or more residues containing the paired basic amino acids near the centre [3] | None | None | bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin; pro-oxytocin/neurophysin convertase; prooxyphysin proteinase; pro-oxytocin convertase | |
| 3.4.24.63 | meprin B | False | 3 | 4 | 4 | 4 | Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain | None | None | meprin-b | |
| 3.4.24.64 | mitochondrial processing peptidase | False | 13 | 3395 | 5 | 19 | Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 | None | None | processing enhancing peptidase (for one of two subunits); mitochondrial protein precursor-processing proteinase; matrix peptidase; matrix processing peptidase; matrix processing proteinase; MPP | |
| 3.4.24.65 | macrophage elastase | False | 4 | 4 | 84 | 3 | Hydrolysis of soluble and insoluble elastin [1]. Specific cleavages are also produced at -Ala14!Leu- and -Tyr16!Leu- in the B chain of insulin [2] | None | None | metalloelastase; human macrophage metalloelastase (HME) | |
| 3.4.24.66 | choriolysin L | False | 1 | 0 | 0 | 5 | Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr!7-(4-methyl)coumarylamide | None | None | teleost hatching enzyme (component); low choriolytic enzyme (LCE) | |
| 3.4.24.67 | choriolysin H | False | 3 | 2 | 1 | 10 | Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr!7-(4-methyl)coumarylamide | None | None | teleost hatching enzyme (component); high choriolytic enzyme (HCE) | |
| 3.4.24.68 | tentoxilysin | False | 1 | 7 | 18 | 1 | Hydrolysis of -Gln76!Phe- bond in synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP) | None | None | tetanus neurotoxin | |
| 3.4.24.69 | bontoxilysin | False | 16 | 56 | 135 | 6 | Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates | None | None | botulinum neurotoxin; BoNT | |
| 3.4.24.70 | oligopeptidase A | False | 5 | 12510 | 1 | 37 | Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly!Gly-Pro-Ala is cleaved, but not Z-(Gly)5 [4] | None | None | 68000-M signalpeptide hydrolase | |
| 3.4.24.71 | endothelin-converting enzyme 1 | False | 11 | 3570 | 1 | 7 | Hydrolysis of the -Trp21!Val- bond in big endothelin to form endothelin 1 | None | None | endothelin-converting enzyme; ECE-1 | |
| 3.4.24.72 | fibrolase | False | 2 | 3 | 0 | 21 | Hydrolysis of -Ala14!Leu- in insulin B chain and -Lys413!Leu- in Aalpha-chain of fibrinogen | None | None | fibrinolytic proteinase; Agkistrodon contortrix contortrix metalloproteinase; Agkistrodon contortrix contortrix venom metalloproteinase | |
| 3.4.24.73 | jararhagin | False | 1 | 0 | 0 | 1 | Hydrolysis of -His10!Leu-, -Ala14!Leu-, -Tyr16!Leu-and -Phe24!Phe- bonds in insulin B chain | None | None | HF2-proteinase; JF1 | |
| 3.4.24.74 | fragilysin | False | 1 | 14 | 3 | 1 | Broad proteolytic specificity, bonds hydrolysed including -Gly!Leu-, -Met!Leu-, -Phe!Leu-, -Cys!Leu-, Leu!Gly | None | None | Bacteroides fragilis (entero)toxin | |
| 3.4.24.75 | lysostaphin | False | 11 | 1596 | 18 | 10 | Hydrolysis of the -Gly!Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans | None | None | glycyl-glycine endopeptidase | |
| 3.4.24.76 | flavastacin | False | 1 | 51 | 0 | 1 | Hydrolyses polypeptides on the amino-side of Asp in -Xaa!Asp-. Acts very slowly on -Xaa!Glu | None | None | None | |
| 3.4.24.77 | snapalysin | False | 5 | 1989 | 1 | 7 | Hydrolyses proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides | None | None | small neutral protease; SnpA gene product (Streptomyces lividans) | |
| 3.4.24.78 | gpr endopeptidase | False | 29 | 3589 | 0 | 7 | Endopeptidase action with P4 Glu or Asp, P1 preferably Glu Asp, P1' hydrophobic and P2' Ala | None | None | germination proteinase | |
| 3.4.24.79 | pappalysin-1 | False | 2 | 23 | 7 | 13 | Cleavage of the Met135!Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143!Lys bond in IGFBP-5 | None | None | insulin-like growth factor binding protein-4 protease; pregnancy-associated plasma protein-A | |
| 3.4.24.80 | membrane-type matrix metalloproteinase-1 | False | 7 | 363 | 10 | 9 | Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain | None | None | matrix metalloproteinase 14 | |
| 3.4.24.81 | ADAM10 endopeptidase | False | 7 | 3075 | 6 | 8 | Endopeptidase of broad specificity | None | None | Kuzbanian protein; myelin-associated disintegrin metalloproteinase | |
| 3.4.24.82 | ADAMTS-4 endopeptidase | False | 5 | 290 | 5 | 6 | Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373!Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan | None | None | aggrecanase-1 | |
| 3.4.24.83 | anthrax lethal factor endopeptidase | False | 1 | 11 | 27 | 2 | Preferred amino acids around the cleavage site can be denoted BBBBxHx!H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases | None | None | lethal toxin | |
| 3.4.24.84 | Ste24 endopeptidase | False | 9 | 4623 | 5 | 5 | Hydrolyses the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue. | None | None | None | |
| 3.4.24.85 | S2P endopeptidase | False | 5 | 1508 | 2 | 34 | Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSRILL483!CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced. | None | None | None | |
| 3.4.24.86 | ADAM 17 endopeptidase | False | 4 | 44 | 26 | 9 | Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains | None | None | tumor necrosis factor alpha-converting enzyme; TACE | |
| 3.4.25.1 | proteasome endopeptidase complex | False | 241 | 16509 | 513 | 43 | Cleavage of peptide bonds with very broad specificity | None | None | ingensin; macropain; multicatalytic endopeptidase complex; prosome; multicatalytic proteinase (complex); MCP; proteasome; large multicatalytic protease; multicatalytic proteinase; proteasome organelle; alkaline protease; 26S protease; tricorn proteinase; tricorn protease | |
| 4.1.1.1 | pyruvate decarboxylase | False | 33 | 2873 | 21 | 69 | a 2-oxo carboxylate = an aldehyde + CO2 | 2-oxo-acid carboxy-lyase (aldehyde-forming) | None | alpha-carboxylase (ambiguous); pyruvic decarboxylase; alpha-ketoacid carboxylase; 2-oxo-acid carboxy-lyase | |
| 4.1.1.2 | oxalate decarboxylase | False | 4 | 494 | 10 | 20 | oxalate + H+ = formate + CO2 | oxalate carboxy-lyase (formate-forming) | None | oxalate carboxy-lyase | |
| 4.1.1.4 | acetoacetate decarboxylase | False | 33 | 1600 | 4 | 6 | acetoacetate + H+ = acetone + CO2 | acetoacetate carboxy-lyase (acetone-forming) | None | acetoacetic acid decarboxylase; acetoacetate carboxy-lyase | |
| 4.1.1.5 | acetolactate decarboxylase | False | 11 | 5481 | 13 | 50 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate = (3R)-3-hydroxybutan-2-one + CO2 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(3R)-3-hydroxybutan-2-one-forming] | None | alpha-acetolactate decarboxylase; (S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase; (S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]; (S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(3R)-3-hydroxybutan-2-one-forming] | |
| 4.1.1.6 | cis-aconitate decarboxylase | False | 4 | 19 | 1 | 4 | cis-aconitate = itaconate + CO2 | cis-aconitate carboxy-lyase (itaconate-forming) | None | cis-aconitic decarboxylase; cis-aconitate carboxy-lyase; CAD1 (gene name); IRG1 (gene name) | |
| 4.1.1.7 | benzoylformate decarboxylase | False | 2 | 1329 | 49 | 7 | phenylglyoxylate = benzaldehyde + CO2 | phenylglyoxylate carboxy-lyase (benzaldehyde-forming) | None | phenylglyoxylate decarboxylase; benzoylformate carboxy-lyase; benzoylformate carboxy-lyase (benzaldehyde-forming) | |
| 4.1.1.8 | oxalyl-CoA decarboxylase | False | 3 | 1360 | 11 | 21 | oxalyl-CoA = formyl-CoA + CO2 | oxalyl-CoA carboxy-lyase (formyl-CoA-forming) | None | oxalyl coenzyme A decarboxylase; oxalyl-CoA carboxy-lyase | |
| 4.1.1.9 | malonyl-CoA decarboxylase | False | 4 | 310 | 4 | 21 | malonyl-CoA = acetyl-CoA + CO2 | malonyl-CoA carboxy-lyase (acetyl-CoA-forming) | None | malonyl coenzyme A decarboxylase; malonyl-CoA carboxy-lyase | |
| 4.1.1.11 | aspartate 1-decarboxylase | False | 452 | 21971 | 35 | 23 | L-aspartate = beta-alanine + CO2 | L-aspartate 1-carboxy-lyase (beta-alanine-forming) | None | aspartate alpha-decarboxylase; L-aspartate alpha-decarboxylase; aspartic alpha-decarboxylase; L-aspartate 1-carboxy-lyase | |
| 4.1.1.12 | aspartate 4-decarboxylase | False | 2 | 497 | 5 | 24 | L-aspartate = L-alanine + CO2 | L-aspartate 4-carboxy-lyase (L-alanine-forming) | None | desulfinase; aminomalonic decarboxylase; aspartate beta-decarboxylase; aspartate omega-decarboxylase; aspartic omega-decarboxylase; aspartic beta-decarboxylase; L-aspartate beta-decarboxylase; cysteine sulfinic desulfinase; L-cysteine sulfinate acid desulfinase; L-aspartate 4-carboxy-lyase | |
| 4.1.1.14 | valine decarboxylase | True | 0 | 0 | 0 | 16 | L-valine = 2-methylpropanamine + CO2 | L-valine carboxy-lyase (2-methylpropanamine-forming) | None | leucine decarboxylase; L-valine carboxy-lyase | |
| 4.1.1.15 | glutamate decarboxylase | False | 43 | 12883 | 26 | 56 | L-glutamate = 4-aminobutanoate + CO2 | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) | None | L-glutamic acid decarboxylase; L-glutamic decarboxylase; cysteic acid decarboxylase; L-glutamate alpha-decarboxylase; aspartate 1-decarboxylase; aspartic alpha-decarboxylase; L-aspartate-alpha-decarboxylase; gamma-glutamate decarboxylase; L-glutamate 1-carboxy-lyase | |
| 4.1.1.16 | hydroxyglutamate decarboxylase | True | 0 | 0 | 0 | 1 | 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2 | 3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming) | None | 3-hydroxy-L-glutamate 1-carboxy-lyase | |
| 4.1.1.17 | ornithine decarboxylase | False | 32 | 13925 | 18 | 97 | L-ornithine = putrescine + CO2 | L-ornithine carboxy-lyase (putrescine-forming) | None | SpeC; L-ornithine carboxy-lyase | |
| 4.1.1.18 | lysine decarboxylase | False | 9 | 1635 | 18 | 74 | L-lysine = cadaverine + CO2 | L-lysine carboxy-lyase (cadaverine-forming) | None | L-lysine carboxy-lyase | |
| 4.1.1.19 | arginine decarboxylase | False | 175 | 19024 | 14 | 83 | L-arginine = agmatine + CO2 | L-arginine carboxy-lyase (agmatine-forming) | None | SpeA; L-arginine carboxy-lyase | |
| 4.1.1.20 | diaminopimelate decarboxylase | False | 42 | 38396 | 18 | 37 | meso-2,6-diaminoheptanedioate = L-lysine + CO2 | meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming) | None | diaminopimelic acid decarboxylase; meso-diaminopimelate decarboxylase; DAP-decarboxylase; meso-2,6-diaminoheptanedioate carboxy-lyase | |
| 4.1.1.21 | phosphoribosylaminoimidazole carboxylase | False | 20 | 3946 | 38 | 15 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming] | None | 5-phosphoribosyl-5-aminoimidazole carboxylase; 5-amino-1-ribosylimidazole 5-phosphate carboxylase; AIR carboxylase; 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase; ADE2; class II PurE; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase | |
| 4.1.1.22 | histidine decarboxylase | False | 25 | 2419 | 11 | 38 | L-histidine = histamine + CO2 | L-histidine carboxy-lyase (histamine-forming) | None | L-histidine decarboxylase; L-histidine carboxy-lyase | |
| 4.1.1.23 | orotidine-5'-phosphate decarboxylase | False | 580 | 47169 | 205 | 25 | orotidine 5'-phosphate = UMP + CO2 | orotidine-5'-phosphate carboxy-lyase (UMP-forming) | None | orotidine-5'-monophosphate decarboxylase; orotodylate decarboxylase; orotidine phosphate decarboxylase; OMP decarboxylase; orotate monophosphate decarboxylase; orotidine monophosphate decarboxylase; orotidine phosphate decarboxylase; OMP-DC; orotate decarboxylase; orotidine 5'-phosphate decarboxylase; orotidylic decarboxylase; orotidylic acid decarboxylase; orotodylate decarboxylase; ODCase; orotic decarboxylase; orotidine-5'-phosphate carboxy-lyase | |
| 4.1.1.24 | aminobenzoate decarboxylase | False | 0 | 2 | 0 | 1 | 4(or 2)-aminobenzoate = aniline + CO2 | aminobenzoate carboxy-lyase (aniline-forming) | None | None | |
| 4.1.1.25 | tyrosine decarboxylase | False | 38 | 826 | 4 | 40 | L-tyrosine = tyramine + CO2 | L-tyrosine carboxy-lyase (tyramine-forming) | None | L-tyrosine decarboxylase; L-(-)-tyrosine apodecarboxylase; L-tyrosine carboxy-lyase | |
| 4.1.1.28 | aromatic-L-amino-acid decarboxylase | False | 18 | 6313 | 11 | 53 | (1) L-dopa = dopamine + CO2;;(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 | aromatic-L-amino-acid carboxy-lyase | None | DOPA decarboxylase; tryptophan decarboxylase; hydroxytryptophan decarboxylase; L-DOPA decarboxylase; aromatic amino acid decarboxylase; 5-hydroxytryptophan decarboxylase; aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) | |
| 4.1.1.29 | sulfinoalanine decarboxylase | False | 8 | 54 | 3 | 25 | 3-sulfino-L-alanine = hypotaurine + CO2 | 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming) | None | cysteine-sulfinate decarboxylase; L-cysteinesulfinic acid decarboxylase; cysteine-sulfinate decarboxylase; CADCase/CSADCase; CSAD; cysteic decarboxylase; cysteinesulfinic acid decarboxylase; cysteinesulfinate decarboxylase; sulfoalanine decarboxylase; 3-sulfino-L-alanine carboxy-lyase | |
| 4.1.1.30 | pantothenoylcysteine decarboxylase | True | 0 | 0 | 0 | 4 | N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2 | N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming) | None | pantothenylcysteine decarboxylase; N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase | |
| 4.1.1.31 | phosphoenolpyruvate carboxylase | False | 264 | 18823 | 22 | 110 | phosphate + oxaloacetate = phosphoenolpyruvate + HCO3- | phosphate:oxaloacetate carboxy-lyase (adding phosphate, phosphoenolpyruvate-forming) | None | phosphopyruvate (phosphate) carboxylase; PEP carboxylase; phosphoenolpyruvic carboxylase; PEPC; PEPCase; phosphate:oxaloacetate carboxy-lyase (phosphorylating) | |
| 4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) | False | 95 | 15966 | 68 | 33 | GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2 | GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming) | None | phosphoenolpyruvate carboxylase (ambiguous); phosphopyruvate carboxylase (ambiguous); phosphopyruvate (guanosine triphosphate) carboxykinase; phosphoenolpyruvic carboxykinase (GTP); phosphopyruvate carboxylase (GTP); phosphoenolpyruvic carboxylase (GTP); phosphoenolpyruvic carboxykinase (ambiguous); phosphoenolpyruvate carboxykinase (ambiguous); PEP carboxylase (ambiguous); GTP:oxaloacetate carboxy-lyase (transphosphorylating) | |
| 4.1.1.33 | diphosphomevalonate decarboxylase | False | 19 | 7733 | 33 | 27 | ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2 | ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming) | None | pyrophosphomevalonate decarboxylase; mevalonate-5-pyrophosphate decarboxylase; pyrophosphomevalonic acid decarboxylase; 5-pyrophosphomevalonate decarboxylase; mevalonate 5-diphosphate decarboxylase; ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating) | |
| 4.1.1.34 | dehydro-L-gulonate decarboxylase | True | 0 | 0 | 0 | 2 | 3-dehydro-L-gulonate = L-xylulose + CO2 | 3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming) | None | keto-L-gulonate decarboxylase; 3-keto-L-gulonate decarboxylase; 3-dehydro-L-gulonate carboxy-lyase | |
| 4.1.1.35 | UDP-glucuronate decarboxylase | False | 12 | 14792 | 5 | 26 | UDP-D-glucuronate = UDP-D-xylose + CO2 | UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming) | None | uridine-diphosphoglucuronate decarboxylase; UDP-D-glucuronate carboxy-lyase | |
| 4.1.1.36 | phosphopantothenoylcysteine decarboxylase | False | 24 | 37008 | 11 | 18 | N-[(R)-4'-phosphopantothenoyl]-L-cysteine = pantotheine 4'-phosphate + CO2 | N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming) | None | 4-phosphopantotheoylcysteine decarboxylase; 4-phosphopantothenoyl-L-cysteine decarboxylase; PPC-decarboxylase; N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase | |
| 4.1.1.37 | uroporphyrinogen decarboxylase | False | 514 | 32713 | 27 | 18 | uroporphyrinogen III = coproporphyrinogen III + 4 CO2 | uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming) | None | uroporphyrinogen III decarboxylase; porphyrinogen carboxy-lyase; porphyrinogen decarboxylase; uroporphyrinogen-III carboxy-lyase | |
| 4.1.1.38 | phosphoenolpyruvate carboxykinase (diphosphate) | False | 4 | 10 | 1 | 9 | diphosphate + oxaloacetate = phosphate + phosphoenolpyruvate + CO2 | diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming) | None | phosphopyruvate carboxylase (ambiguous); PEP carboxyphosphotransferase (ambiguous); PEP carboxykinase (ambiguous); phosphopyruvate carboxykinase (pyrophosphate); PEP carboxylase (ambiguous); phosphopyruvate carboxykinase (ambiguous); phosphoenolpyruvic carboxykinase (ambiguous); phosphoenolpyruvic carboxylase (ambiguous); phosphoenolpyruvate carboxytransphosphorylase (ambiguous); phosphoenolpyruvate carboxykinase (ambiguous); phosphoenolpyruvic carboxykinase; phosphoenolpyruvic carboxylase; PEPCTrP; phosphoenolpyruvic carboxykinase (pyrophosphate); phosphoenolpyruvic carboxylase (pyrophosphate); phosphoenolpyruvate carboxylase (ambiguous); phosphoenolpyruvate carboxyphosphotransferase (ambiguous); phosphoenolpyruvic carboxytransphosphorylase (ambiguous); phosphoenolpyruvate carboxylase (pyrophosphate); phosphopyruvate carboxylase (pyrophosphate); diphosphate:oxaloacetate carboxy-lyase (transphosphorylating) | |
| 4.1.1.39 | ribulose-bisphosphate carboxylase | False | 697 | 173753 | 121 | 302 | 2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O | 3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming) | None | D-ribulose 1,5-diphosphate carboxylase; D-ribulose-1,5-bisphosphate carboxylase; RuBP carboxylase; carboxydismutase; diphosphoribulose carboxylase; ribulose 1,5-bisphosphate carboxylase; ribulose 1,5-bisphosphate carboxylase/oxygenase; ribulose 1,5-diphosphate carboxylase; ribulose 1,5-diphosphate carboxylase/oxygenase; ribulose bisphosphate carboxylase/oxygenase; ribulose diphosphate carboxylase; ribulose diphosphate carboxylase/oxygenase; rubisco; 3-phospho-D-glycerate carboxy-lyase (dimerizing) | |
| 4.1.1.40 | hydroxypyruvate decarboxylase | True | 0 | 0 | 0 | 5 | hydroxypyruvate = glycolaldehyde + CO2 | hydroxypyruvate carboxy-lyase (glycolaldehyde-forming) | None | hydroxypyruvate carboxy-lyase | |
| 4.1.1.42 | carnitine decarboxylase | True | 0 | 0 | 0 | 2 | carnitine = 2-methylcholine + CO2 | carnitine carboxy-lyase (2-methylcholine-forming) | None | carnitine carboxy-lyase | |
| 4.1.1.43 | phenylpyruvate decarboxylase | False | 4 | 136 | 5 | 17 | phenylpyruvate = phenylacetaldehyde + CO2 | 3-phenyl-2-oxopropanoate carboxy-lyase (phenylacetaldehyde-forming) | None | phenylpyruvate carboxy-lyase; phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming) | |
| 4.1.1.44 | 4-carboxymuconolactone decarboxylase | False | 2 | 4978 | 1 | 20 | (R)-2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2 | (R)-2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming) | None | gamma-4-carboxymuconolactone decarboxylase; 4-carboxymuconolactone carboxy-lyase; 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming) | |
| 4.1.1.45 | aminocarboxymuconate-semialdehyde decarboxylase | False | 7 | 1848 | 8 | 7 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming) | None | picolinic acid carboxylase; picolinic acid decarboxylase; alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase; alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase; 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase; 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase | |
| 4.1.1.46 | o-pyrocatechuate decarboxylase | False | 2 | 81 | 1 | 9 | 2,3-dihydroxybenzoate = catechol + CO2 | 2,3-dihydroxybenzoate carboxy-lyase (catechol-forming) | None | 2,3-dihydroxybenzoate carboxy-lyase | |
| 4.1.1.47 | tartronate-semialdehyde synthase | False | 2 | 3240 | 7 | 8 | 2 glyoxylate = 2-hydroxy-3-oxopropanoate + CO2 | glyoxylate carboxy-lyase (dimerizing; 2-hydroxy-3-oxopropanoate-forming) | None | tartronate semialdehyde carboxylase; glyoxylate carbo-ligase; glyoxylic carbo-ligase; hydroxymalonic semialdehyde carboxylase; tartronic semialdehyde carboxylase; glyoxalate carboligase; glyoxylate carboxy-lyase (dimerizing); glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming) | |
| 4.1.1.48 | indole-3-glycerol-phosphate synthase | False | 407 | 41323 | 33 | 30 | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming] | None | indoleglycerol phosphate synthetase; indoleglycerol phosphate synthase; indole-3-glycerophosphate synthase; 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing) | |
| 4.1.1.49 | phosphoenolpyruvate carboxykinase (ATP) | False | 286 | 25201 | 27 | 56 | ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2 | ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming) | None | phosphopyruvate carboxylase (ATP); phosphoenolpyruvate carboxylase (ambiguous); phosphoenolpyruvate carboxykinase (ambiguous); phosphopyruvate carboxykinase (adenosine triphosphate); PEP carboxylase (ambiguous); PEP carboxykinase (ambiguous); PEPCK (ATP); PEPK; PEPCK; phosphoenolpyruvic carboxylase (ambiguous); phosphoenolpyruvic carboxykinase (ambiguous); phosphoenolpyruvate carboxylase (ATP); phosphopyruvate carboxykinase (ambiguous); ATP:oxaloacetate carboxy-lyase (transphosphorylating) | |
| 4.1.1.50 | adenosylmethionine decarboxylase | False | 261 | 16606 | 37 | 50 | S-adenosyl-L-methionine = S-adenosyl 3-(methylsulfanyl)propylamine + CO2 | S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylsulfanyl)propylamine-forming] | None | S-adenosylmethionine decarboxylase; S-adenosyl-L-methionine decarboxylase; S-adenosyl-L-methionine carboxy-lyase; S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] | |
| 4.1.1.51 | 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase | False | 1 | 5 | 1 | 2 | 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2 | 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming) | None | 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase | |
| 4.1.1.52 | 6-methylsalicylate decarboxylase | False | 6 | 2597 | 0 | 4 | 6-methylsalicylate = 3-methylphenol + CO2 | 6-methylsalicylate carboxy-lyase (3-methylphenol-forming) | None | 6-methylsalicylic acid (2,6-cresotic acid) decarboxylase; 6-MSA decarboxylase; 6-methylsalicylate carboxy-lyase | |
| 4.1.1.53 | phenylalanine decarboxylase | False | 0 | 3 | 0 | 16 | L-phenylalanine = phenylethylamine + CO2 | L-phenylalanine carboxy-lyase (phenylethylamine-forming) | None | L-phenylalanine decarboxylase; aromatic L-amino acid decarboxylase (ambiguous); L-phenylalanine carboxy-lyase | |
| 4.1.1.54 | dihydroxyfumarate decarboxylase | True | 0 | 0 | 0 | 1 | dihydroxyfumarate = 2-hydroxy-3-oxopropanoate + CO2 | dihydroxyfumarate carboxy-lyase (2-hydroxy-3-oxopropanoate-forming) | None | dihydroxyfumarate carboxy-lyase; dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming) | |
| 4.1.1.55 | 4,5-dihydroxyphthalate decarboxylase | False | 2 | 320 | 0 | 5 | 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2 | 4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming) | None | 4,5-dihydroxyphthalate carboxy-lyase | |
| 4.1.1.56 | 3-oxolaurate decarboxylase | False | 0 | 25 | 0 | 2 | 3-oxododecanoate = 2-undecanone + CO2 | 3-oxododecanoate carboxy-lyase (2-undecanone-forming) | None | beta-ketolaurate decarboxylase; beta-ketoacyl decarboxylase; 3-oxododecanoate carboxy-lyase | |
| 4.1.1.57 | methionine decarboxylase | False | 0 | 0 | 5 | 3 | L-methionine = 3-(methylsulfanyl)propanamine + CO2 | L-methionine carboxy-lyase [3-(methylsulfanyl)propanamine-forming] | None | L-methionine decarboxylase; L-methionine carboxy-lyase; L-methionine carboxy-lyase (3-methylthiopropanamine-forming) | |
| 4.1.1.58 | orsellinate decarboxylase | True | 0 | 0 | 0 | 2 | orsellinate = orcinol + CO2 | 2,4-dihydroxy-6-methylbenzoate carboxy-lyase (orcinol-forming) | None | orsellinate carboxy-lyase | |
| 4.1.1.59 | gallate decarboxylase | False | 1 | 6 | 0 | 12 | 3,4,5-trihydroxybenzoate = 1,2,3-trihydroxybenzene + CO2 | 3,4,5-trihydroxybenzoate carboxy-lyase (1,2,3-trihydroxybenzene-forming) | None | gallic acid decarboxylase; gallate carboxy-lyase; 3,4,5-trihydroxybenzoate carboxy-lyase (pyrogallol-forming) | |
| 4.1.1.60 | stipitatonate decarboxylase | True | 0 | 0 | 0 | 1 | stipitatonate = stipitatate + CO2 | stipitatonate carboxy-lyase (ring-opening, stipitatate-forming) | None | stipitatonate carboxy-lyase (decyclizing); stipitatonate carboxy-lyase (decyclizing, stipitatate-forming) | |
| 4.1.1.61 | 4-hydroxybenzoate decarboxylase | False | 4 | 215 | 7 | 13 | 4-hydroxybenzoate = phenol + CO2 | 4-hydroxybenzoate carboxy-lyase (phenol-forming) | None | p-hydroxybenzoate decarboxylase; 4-hydroxybenzoate carboxy-lyase | |
| 4.1.1.62 | gentisate decarboxylase | True | 0 | 0 | 0 | 1 | 2,5-dihydroxybenzoate = hydroquinone + CO2 | 2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming) | None | 2,5-dihydroxybenzoate decarboxylase; gentisate carboxy-lyase | |
| 4.1.1.63 | protocatechuate decarboxylase | False | 3 | 10 | 3 | 5 | 3,4-dihydroxybenzoate = catechol + CO2 | 3,4-dihydroxybenzoate carboxy-lyase (catechol-forming) | None | 3,4-dihydrobenzoate decarboxylase; protocatechuate carboxy-lyase | |
| 4.1.1.64 | 2,2-dialkylglycine decarboxylase (pyruvate) | False | 1 | 325 | 16 | 10 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine | 2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming) | None | dialkyl amino acid (pyruvate) decarboxylase; alpha-dialkyl amino acid transaminase; 2,2-dialkyl-2-amino acid-pyruvate aminotransferase; L-alanine-alpha-ketobutyrate aminotransferase; dialkylamino-acid decarboxylase (pyruvate); 2,2-dialkylglycine carboxy-lyase (amino-transferring) | |
| 4.1.1.65 | phosphatidylserine decarboxylase | False | 477 | 33201 | 6 | 34 | phosphatidyl-L-serine = phosphatidylethanolamine + CO2 | phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming) | None | PS decarboxylase; phosphatidyl-L-serine carboxy-lyase | |
| 4.1.1.66 | uracil-5-carboxylate decarboxylase | False | 0 | 1 | 4 | 1 | uracil 5-carboxylate = uracil + CO2 | uracil-5-carboxylate carboxy-lyase (uracil-forming) | None | uracil-5-carboxylic acid decarboxylase; uracil-5-carboxylate carboxy-lyase | |
| 4.1.1.67 | UDP-galacturonate decarboxylase | True | 0 | 0 | 0 | 1 | UDP-D-galacturonate = UDP-L-arabinose + CO2 | UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming) | None | UDP-galacturonic acid decarboxylase; UDPGalUA carboxy lyase; UDP-D-galacturonate carboxy-lyase | |
| 4.1.1.68 | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase | False | 3 | 626 | 0 | 1 | (3E,5R)-5-carboxy-2-oxohept-3-enedioate = (4Z)-2-oxohept-4-enedioate + CO2 (overall reaction);;(1a) (3E,5R)-5-carboxy-2-oxohept-3-enedioate = (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate + CO2;;(1b) (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate = (4Z)-2-oxohept-4-enedioate | (3E,5R)-5-carboxy-2-oxohept-3-enedioate carboxy-lyase [(4Z)-2-oxohept-4-enedioate-forming] | None | 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase; 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase; 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming) | |
| 4.1.1.69 | 3,4-dihydroxyphthalate decarboxylase | False | 0 | 16 | 0 | 3 | 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2 | 3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming) | None | 3,4-dihydroxyphthalate carboxy-lyase | |
| 4.1.1.71 | 2-oxoglutarate decarboxylase | False | 13 | 2951 | 5 | 8 | 2-oxoglutarate = succinate semialdehyde + CO2 | 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming) | None | oxoglutarate decarboxylase; alpha-ketoglutarate decarboxylase; alpha-ketoglutaric decarboxylase; pre-2-oxoglutarate decarboxylase; 2-oxoglutarate carboxy-lyase | |
| 4.1.1.72 | branched-chain-2-oxoacid decarboxylase | False | 5 | 86 | 0 | 10 | (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2 | (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming) | None | branched-chain oxo acid decarboxylase; branched-chain alpha-keto acid decarboxylase; branched-chain keto acid decarboxylase; BCKA; (3S)-3-methyl-2-oxopentanoate carboxy-lyase | |
| 4.1.1.73 | tartrate decarboxylase | False | 7 | 2340 | 0 | 1 | (R,R)-tartrate = D-glycerate + CO2 | (R,R)-tartrate carboxy-lyase (D-glycerate-forming) | None | (R,R)-tartrate carboxy-lyase | |
| 4.1.1.74 | indolepyruvate decarboxylase | False | 6 | 667 | 1 | 8 | 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2 | 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming] | None | indol-3-yl-pyruvate carboxy-lyase; 3-(indol-3-yl)pyruvate carboxy-lyase | |
| 4.1.1.75 | 5-guanidino-2-oxopentanoate decarboxylase | False | 1 | 884 | 0 | 2 | 5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 | 5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming) | None | alpha-ketoarginine decarboxylase; 2-oxo-5-guanidinopentanoate carboxy-lyase | |
| 4.1.1.76 | arylmalonate decarboxylase | False | 1 | 263 | 8 | 6 | 2-aryl-2-methylmalonate = 2-arylpropanoate + CO2 | 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming) | None | AMDASE; 2-aryl-2-methylmalonate carboxy-lyase; 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming) | |
| 4.1.1.77 | 2-oxo-3-hexenedioate decarboxylase | False | 3 | 720 | 6 | 6 | (3E)-2-oxohex-3-enedioate = 2-oxopent-4-enoate + CO2 | (3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming) | None | 4-oxalocrotonate carboxy-lyase (misleading); 4-oxalocrotonate decarboxylase (misleading); cnbF (gene name); praD (gene name); amnE (gene name); nbaG (gene name); xylI (gene name) | |
| 4.1.1.78 | acetylenedicarboxylate decarboxylase | True | 0 | 0 | 0 | 1 | acetylenedicarboxylate + H2O = pyruvate + CO2 | acetylenedicarboxylate carboxy-lyase (pyruvate-forming) | None | acetylenedicarboxylate hydratase; acetylenedicarboxylate hydrase; acetylenedicarboxylate carboxy-lyase | |
| 4.1.1.79 | sulfopyruvate decarboxylase | False | 7 | 1269 | 0 | 4 | 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2 | 3-sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming) | None | sulfopyruvate carboxy-lyase | |
| 4.1.1.80 | 4-hydroxyphenylpyruvate decarboxylase | False | 1 | 1 | 0 | 10 | 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2 | 4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming) | None | 4-hydroxyphenylpyruvate carboxy-lyase | |
| 4.1.1.81 | threonine-phosphate decarboxylase | False | 6 | 8969 | 0 | 3 | L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2 | L-threonine-O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming] | None | L-threonine-O-3-phosphate decarboxylase; CobD; L-threonine-O-3-phosphate carboxy-lyase | |
| 4.1.1.82 | phosphonopyruvate decarboxylase | False | 2 | 964 | 0 | 3 | 3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2 | 3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) | None | 3-phosphonopyruvate carboxy-lyase | |
| 4.1.1.83 | 4-hydroxyphenylacetate decarboxylase | False | 10 | 928 | 2 | 2 | (4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2 | (4-hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming) | None | p-hydroxyphenylacetate decarboxylase; p-Hpd; 4-Hpd; 4-hydroxyphenylacetate carboxy-lyase | |
| 4.1.1.84 | D-dopachrome decarboxylase | False | 8 | 828 | 17 | 4 | D-dopachrome = 5,6-dihydroxyindole + CO2 | D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) | None | phenylpyruvate tautomerase II; D-tautomerase; D-dopachrome tautomerase; D-dopachrome carboxy-lyase | |
| 4.1.1.85 | 3-dehydro-L-gulonate-6-phosphate decarboxylase | False | 42 | 1154 | 3 | 3 | 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2 | 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) | None | 3-keto-L-gulonate 6-phosphate decarboxylase; UlaD; SgaH; SgbH; KGPDC; 3-dehydro-L-gulonate-6-phosphate carboxy-lyase | |
| 4.1.2.2 | ketotetrose-phosphate aldolase | False | 0 | 36 | 0 | 2 | erythrulose 1-phosphate = glycerone phosphate + formaldehyde | erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming) | None | phosphoketotetrose aldolase; erythrulose-1-phosphate synthetase; erythrose-1-phosphate synthase; erythrulose-1-phosphate formaldehyde-lyase | |
| 4.1.2.4 | deoxyribose-phosphate aldolase | False | 338 | 33483 | 34 | 37 | 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde | 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming) | None | phosphodeoxyriboaldolase; deoxyriboaldolase; deoxyribose-5-phosphate aldolase; 2-deoxyribose-5-phosphate aldolase; 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase | |
| 4.1.2.5 | L-threonine aldolase | False | 0 | 1477 | 9 | 9 | L-threonine = glycine + acetaldehyde | L-threonine acetaldehyde-lyase (glycine-forming) | None | L-threonine acetaldehyde-lyase | |
| 4.1.2.9 | phosphoketolase | False | 2 | 409 | 0 | 46 | D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O | D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming) | None | D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) | |
| 4.1.2.10 | (R)-mandelonitrile lyase | False | 9 | 383 | 21 | 21 | (R)-mandelonitrile = cyanide + benzaldehyde | (R)-mandelonitrile benzaldehyde-lyase (cyanide-forming) | None | (R)-oxynitrilase; oxynitrilase; D-oxynitrilase; D-alpha-hydroxynitrile lyase; mandelonitrile benzaldehyde-lyase; PaHNL; AtHNL; PhaMDL; (R)-HNL; (R)-PeHNL; (R)-hydroxynitrile lyase; R-selective hydroxynitrile lyase; R-selective HNL; (R)-(+)-mandelonitrile lyase | |
| 4.1.2.11 | hydroxymandelonitrile lyase | False | 1 | 0 | 1 | 6 | (S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde | (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming) | None | hydroxynitrile lyase; oxynitrilase; Sorghum hydroxynitrile lyase; (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase | |
| 4.1.2.12 | 2-dehydropantoate aldolase | True | 0 | 0 | 0 | 1 | 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde | 2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming) | None | ketopantoaldolase; 2-dehydropantoate formaldehyde-lyase | |
| 4.1.2.13 | fructose-bisphosphate aldolase | False | 188 | 58082 | 151 | 144 | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate | D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) | None | aldolase; fructose-1,6-bisphosphate triosephosphate-lyase; fructose diphosphate aldolase; diphosphofructose aldolase; fructose 1,6-diphosphate aldolase; ketose 1-phosphate aldolase; phosphofructoaldolase; zymohexase; fructoaldolase; fructose 1-phosphate aldolase; fructose 1-monophosphate aldolase; 1,6-diphosphofructose aldolase; SMALDO; D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase | |
| 4.1.2.14 | 2-dehydro-3-deoxy-phosphogluconate aldolase | False | 15 | 18530 | 21 | 23 | 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate | 2-dehydro-3-deoxy-6-phospho-D-gluconate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming) | None | phospho-2-keto-3-deoxygluconate aldolase; KDPG aldolase; phospho-2-keto-3-deoxygluconic aldolase; 2-keto-3-deoxy-6-phosphogluconic aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; 6-phospho-2-keto-3-deoxygluconate aldolase; ODPG aldolase; 2-oxo-3-deoxy-6-phosphogluconate aldolase; 2-keto-3-deoxygluconate-6-P-aldolase; 2-keto-3-deoxygluconate-6-phosphate aldolase; 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase; 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming) | |
| 4.1.2.17 | L-fuculose-phosphate aldolase | False | 11 | 3150 | 29 | 4 | L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde | L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming) | None | L-fuculose 1-phosphate aldolase; fuculose aldolase; L-fuculose-1-phosphate lactaldehyde-lyase | |
| 4.1.2.18 | 2-dehydro-3-deoxy-L-pentonate aldolase | True | 0 | 0 | 0 | 4 | 2-dehydro-3-deoxy-L-pentonate = pyruvate + glycolaldehyde | 2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming) | None | 2-keto-3-deoxy-L-pentonate aldolase; 2-keto-3-deoxy-L-arabonate aldolase; 2-keto-3-deoxy-D-xylonate aldolase; 3-deoxy-D-pentulosonic acid aldolase; 2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase | |
| 4.1.2.19 | rhamnulose-1-phosphate aldolase | False | 66 | 2981 | 15 | 5 | L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde | L-rhamnulose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming) | None | rhamnulose phosphate aldolase; L-rhamnulose 1-phosphate aldolase; L-rhamnulose-phosphate aldolase; L-rhamnulose-1-phosphate lactaldehyde-lyase | |
| 4.1.2.20 | 2-dehydro-3-deoxyglucarate aldolase | False | 42 | 1670 | 15 | 4 | 2-dehydro-3-deoxy-D-glucarate = pyruvate + 2-hydroxy-3-oxopropanoate | 2-dehydro-3-deoxy-D-glucarate 2-hydroxy-3-oxopropanoate-lyase (pyruvate-forming) | None | 2-keto-3-deoxyglucarate aldolase; alpha-keto-beta-deoxy-D-glucarate aldolase; 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase; 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming) | |
| 4.1.2.21 | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase | False | 3 | 2676 | 3 | 10 | 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate | 2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phospho-lyase (pyruvate-forming) | None | 6-phospho-2-keto-3-deoxygalactonate aldolase; phospho-2-keto-3-deoxygalactonate aldolase; 2-keto-3-deoxy-6-phosphogalactonic aldolase; phospho-2-keto-3-deoxygalactonic aldolase; 2-keto-3-deoxy-6-phosphogalactonic acid aldolase; (KDPGal)aldolase; 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase; 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming) | |
| 4.1.2.22 | fructose-6-phosphate phosphoketolase | False | 1 | 248 | 12 | 36 | D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O | D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming) | None | D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) | |
| 4.1.2.23 | 3-deoxy-D-manno-octulosonate aldolase | True | 0 | 0 | 0 | 14 | 3-deoxy-D-manno-octulosonate = pyruvate + D-arabinose | 3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming) | None | 2-keto-3-deoxyoctonate aldolase; KDOaldolase; 3-deoxyoctulosonic aldolase; 2-keto-3-deoxyoctonic aldolase; 3-deoxy-D-manno-octulosonic aldolase; 3-deoxy-D-manno-octulosonate D-arabinose-lyase | |
| 4.1.2.24 | dimethylaniline-N-oxide aldolase | True | 0 | 0 | 0 | 1 | N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde | N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming) | None | microsomal oxidase II; microsomal N-oxide dealkylase; N,N-dimethylaniline-N-oxide formaldehyde-lyase | |
| 4.1.2.25 | dihydroneopterin aldolase | False | 43 | 31707 | 24 | 11 | 7,8-dihydroneopterin = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde | 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] | None | 7,8-dihydroneopterin aldolase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming); DHNA; mptD (gene name); folB (gene name) | |
| 4.1.2.26 | phenylserine aldolase | False | 0 | 2 | 1 | 9 | L-threo-3-phenylserine = glycine + benzaldehyde | L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming) | None | L-threo-3-phenylserine benzaldehyde-lyase | |
| 4.1.2.27 | sphinganine-1-phosphate aldolase | False | 13 | 4289 | 9 | 25 | sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) | None | dihydrosphingosine 1-phosphate aldolase; sphinganine-1-phosphate alkanal-lyase; sphinganine-1-phosphate lyase; sphinganine-1-phosphate palmitaldehyde-lyase | |
| 4.1.2.28 | 2-dehydro-3-deoxy-D-pentonate aldolase | False | 2 | 25 | 0 | 2 | 2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde | 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase (pyruvate-forming) | None | 2-keto-3-deoxy-D-pentonate aldolase; 3-deoxy-D-pentulosonic acid aldolase; 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase | |
| 4.1.2.29 | 5-dehydro-2-deoxyphosphogluconate aldolase | False | 5 | 144 | 0 | 1 | 5-dehydro-2-deoxy-D-gluconate 6-phosphate = glycerone phosphate + malonate semialdehyde | 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (glycerone-phosphate-forming) | None | phospho-5-keto-2-deoxygluconate aldolase; 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase | |
| 4.1.2.32 | trimethylamine-oxide aldolase | False | 1 | 7 | 0 | 13 | trimethylamine N-oxide = dimethylamine + formaldehyde | trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming) | None | trimethylamine N-oxide formaldehyde-lyase; trimethylamine N-oxide aldolase; trimethylamine N-oxide demethylase; trimethylamine-N-oxide formaldehyde-lyase | |
| 4.1.2.33 | fucosterol-epoxide lyase | True | 0 | 0 | 0 | 1 | (24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde | (24R,241R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) | None | (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase; (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) | |
| 4.1.2.34 | 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase | False | 1 | 5 | 0 | 2 | (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate | (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming) | None | 2'-carboxybenzalpyruvate aldolase; (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase; (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase | |
| 4.1.2.35 | propioin synthase | True | 0 | 0 | 0 | 1 | 4-hydroxy-3-hexanone = 2 propanal | 4-hydroxy-3-hexanone propanal-lyase (propanal-forming) | None | 4-hydroxy-3-hexanone aldolase; 4-hydroxy-3-hexanone propanal-lyase | |
| 4.1.2.36 | lactate aldolase | True | 0 | 0 | 0 | 1 | (S)-lactate = formate + acetaldehyde | (S)-lactate acetaldehyde-lyase (formate-forming) | None | lactate synthase; (S)-lactate acetaldehyde-lyase | |
| 4.1.2.38 | benzoin aldolase | False | 1 | 10 | 6 | 4 | 2-hydroxy-1,2-diphenylethanone = 2 benzaldehyde | 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming) | None | benzaldehyde lyase; 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase | |
| 4.1.2.40 | tagatose-bisphosphate aldolase | False | 108 | 5481 | 16 | 8 | D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate | D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) | None | D-tagatose-1,6-bisphosphate triosephosphate lyase | |
| 4.1.3.1 | isocitrate lyase | False | 56 | 12494 | 32 | 79 | isocitrate = succinate + glyoxylate | isocitrate glyoxylate-lyase (succinate-forming) | None | isocitrase; isocitritase; isocitratase; threo-Ds-isocitrate glyoxylate-lyase; isocitrate glyoxylate-lyase | |
| 4.1.3.3 | N-acetylneuraminate lyase | False | 85 | 9008 | 53 | 22 | aceneuramate = N-acetyl-D-mannosamine + pyruvate | aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming) | None | N-acetylneuraminic acid aldolase; acetylneuraminate lyase; sialic aldolase; sialic acid aldolase; sialate lyase; N-acetylneuraminic aldolase; neuraminic aldolase; N-acetylneuraminate aldolase; neuraminic acid aldolase; neuraminate aldolase; N-acetylneuraminic lyase; N-acetylneuraminic acid lyase; NPL; NALase; NANA lyase; acetylneuraminate pyruvate-lyase; N-acetylneuraminate pyruvate-lyase; NanA; N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming) | |
| 4.1.3.4 | hydroxymethylglutaryl-CoA lyase | False | 15 | 12675 | 7 | 17 | (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate | (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) | None | hydroxymethylglutaryl coenzyme A-cleaving enzyme; hydroxymethylglutaryl coenzyme A lyase; 3-hydroxy-3-methylglutaryl coenzyme A lyase; 3-hydroxy-3-methylglutaryl CoA cleaving enzyme; 3-hydroxy-3-methylglutaryl-CoA lyase; (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase | |
| 4.1.3.6 | citrate (pro-3S)-lyase | False | 9 | 7544 | 5 | 23 | citrate = acetate + oxaloacetate | citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate) | None | citrase; citratase; citritase; citridesmolase; citrate aldolase; citric aldolase; citrate lyase; citrate oxaloacetate-lyase; citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate] | |
| 4.1.3.13 | oxalomalate lyase | True | 0 | 0 | 0 | 1 | 3-oxalomalate = oxaloacetate + glyoxylate | 3-oxalomalate glyoxylate-lyase (oxaloacetate-forming) | None | 3-oxalomalate glyoxylate-lyase | |
| 4.1.3.14 | L-erythro-3-hydroxyaspartate aldolase | True | 0 | 0 | 0 | 1 | L-erythro-3-hydroxy-aspartate = glycine + glyoxylate | L-erythro-3-hydroxy-aspartate glyoxylate-lyase (glycine-forming) | None | L-erythro-beta-hydroxyaspartate aldolase; L-erythro-beta-hydroxyaspartate glycine-lyase; erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase | |
| 4.1.3.16 | 4-hydroxy-2-oxoglutarate aldolase | False | 18 | 6953 | 5 | 5 | 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate | 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming) | None | 2-oxo-4-hydroxyglutarate aldolase; hydroxyketoglutaric aldolase; 4-hydroxy-2-ketoglutaric aldolase; 2-keto-4-hydroxyglutaric aldolase; 4-hydroxy-2-ketoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; 2-oxo-4-hydroxyglutaric aldolase; DL-4-hydroxy-2-ketoglutarate aldolase; hydroxyketoglutarate aldolase; 2-keto-4-hydroxybutyrate aldolase; 4-hydroxy-2-oxoglutarate glyoxylate-lyase; KHGA | |
| 4.1.3.17 | 4-hydroxy-4-methyl-2-oxoglutarate aldolase | False | 101 | 12923 | 1 | 7 | (1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate;;(2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate | 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming) | None | pyruvate aldolase; gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase; 4-hydroxy-4-methyl-2-ketoglutarate aldolase; 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase; HMG aldolase; CHA aldolase; 4-carboxy-4-hydroxy-2-oxoadipate aldolase | |
| 4.1.3.22 | citramalate lyase | True | 0 | 0 | 0 | 7 | (2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate | (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming) | None | citramalate pyruvate-lyase; citramalate synthase; citramalic-condensing enzyme; citramalate synthetase; citramalic synthase; (S)-citramalate lyase; (+)-citramalate pyruvate-lyase; citramalate pyruvate lyase; (3S)-citramalate pyruvate-lyase; (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase | |
| 4.1.3.24 | malyl-CoA lyase | False | 10 | 725 | 5 | 11 | (1) (S)-malyl-CoA = acetyl-CoA + glyoxylate;; (2) (2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate | (S)-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming) | None | malyl-coenzyme A lyase; (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase; mclA (gene name); mcl1 (gene name); (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming); L-malyl-CoA lyase | |
| 4.1.3.25 | (S)-citramalyl-CoA lyase | False | 6 | 107 | 0 | 10 | (3S)-citramalyl-CoA = acetyl-CoA + pyruvate | (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming) | None | citramalyl coenzyme A lyase (ambiguous); (+)-CMA-CoA lyase; (3S)-citramalyl-CoA pyruvate-lyase; Mcl (ambiguous); citramalyl-CoA lyase (ambiguous) | |
| 4.1.3.26 | 3-hydroxy-3-isohexenylglutaryl-CoA lyase | False | 1 | 102 | 0 | 2 | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming) | None | beta-hydroxy-beta-isohexenylglutaryl CoA-lyase; hydroxyisohexenylglutaryl-CoA:acetatelyase; 3-hydroxy-3-isohexenylglutaryl coenzyme A lyase; 3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase | |
| 4.1.3.27 | anthranilate synthase | False | 134 | 46593 | 12 | 44 | chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O;;(1c) (2S)-2-amino-4-deoxychorismate = anthranilate + pyruvate | chorismate pyruvate-lyase (amino-accepting; anthranilate-forming) | None | anthranilate synthetase; chorismate lyase; chorismate pyruvate-lyase (amino-accepting); TrpDE | |
| 4.1.3.30 | methylisocitrate lyase | False | 37 | 10775 | 11 | 21 | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = succinate + pyruvate | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) | None | 2-methylisocitrate lyase; MICL; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase | |
| 4.1.3.32 | 2,3-dimethylmalate lyase | False | 1 | 372 | 2 | 3 | (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate | (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming) | None | 2,3-dimethylmalate pyruvate-lyase; (2R,3S)-2,3-dimethylmalate pyruvate-lyase | |
| 4.1.3.34 | citryl-CoA lyase | False | 5 | 3248 | 0 | 12 | (3S)-citryl-CoA = acetyl-CoA + oxaloacetate | (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming) | None | (3S)-citryl-CoA oxaloacetate-lyase | |
| 4.1.3.35 | (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase | True | 0 | 0 | 0 | 1 | (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone | (1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming) | None | (1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase | |
| 4.1.3.36 | 1,4-dihydroxy-2-naphthoyl-CoA synthase | False | 21 | 14819 | 21 | 8 | 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O | 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing) | None | naphthoate synthase; 1,4-dihydroxy-2-naphthoate synthase; dihydroxynaphthoate synthase; o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing); MenB; o-succinylbenzoyl-CoA dehydratase (cyclizing) | |
| 4.1.3.38 | aminodeoxychorismate lyase | False | 8 | 7923 | 3 | 9 | 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) | None | enzyme X; 4-amino-4-deoxychorismate lyase; 4-amino-4-deoxychorismate pyruvate-lyase | |
| 4.1.99.1 | tryptophanase | False | 56 | 2482 | 16 | 33 | L-tryptophan + H2O = indole + pyruvate + NH3 (overall reaction);;(1a) L-tryptophan = indole + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-tryptophan indole-lyase (deaminating; pyruvate-forming) | None | L-tryptophanase; L-tryptophan indole-lyase (deaminating); TNase | |
| 4.1.99.2 | tyrosine phenol-lyase | False | 11 | 1170 | 26 | 17 | L-tyrosine + H2O = phenol + pyruvate + NH3 (overall reaction);;(1a) L-tyrosine = phenol + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-tyrosine phenol-lyase (deaminating; pyruvate-forming) | None | beta-tyrosinase; L-tyrosine phenol-lyase (deaminating) | |
| 4.1.99.3 | deoxyribodipyrimidine photo-lyase | False | 21 | 7427 | 73 | 82 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) | deoxyribocyclobutadipyrimidine pyrimidine-lyase | None | photoreactivating enzyme; DNA photolyase; DNA-photoreactivating enzyme; DNA cyclobutane dipyrimidine photolyase; DNA photolyase; deoxyribonucleic photolyase; deoxyribodipyrimidine photolyase; photolyase; PRE; PhrB photolyase; deoxyribonucleic cyclobutane dipyrimidine photolyase; phr A photolyase; dipyrimidine photolyase (photosensitive); deoxyribonucleate pyrimidine dimer lyase (photosensitive) | |
| 4.1.99.5 | aldehyde oxygenase (deformylating) | False | 25 | 2663 | 18 | 10 | a long-chain aldehyde + O2 + 2 NADPH + 2 H+ = an alkane + formate + H2O + 2 NADP+ | a long-chain aldehyde alkane-lyase | None | decarbonylase; aldehyde decarbonylase; octadecanal decarbonylase; octadecanal alkane-lyase | |
| 4.1.99.11 | benzylsuccinate synthase | False | 3 | 262 | 4 | 17 | benzylsuccinate = toluene + fumarate | benzylsuccinate fumarate-lyase (toluene-forming) | None | benzylsuccinate fumarate-lyase | |
| 4.2.1.1 | carbonic anhydrase | False | 141 | 60625 | 1401 | 156 | H2CO3 = CO2 + H2O | carbonic acid hydro-lyase (carbon-dioxide-forming) | None | carbonate dehydratase; anhydrase; carbonate anhydrase; carbonic acid anhydrase; carboxyanhydrase; carbonic anhydrase A; carbonate hydro-lyase; carbonate hydro-lyase (carbon-dioxide-forming) | |
| 4.2.1.2 | fumarate hydratase | False | 117 | 57612 | 66 | 45 | (S)-malate = fumarate + H2O | (S)-malate hydro-lyase (fumarate-forming) | None | fumarase; L-malate hydro-lyase; (S)-malate hydro-lyase | |
| 4.2.1.3 | aconitate hydratase | False | 76 | 48722 | 20 | 51 | citrate = isocitrate (overall reaction);;(1a) citrate = cis-aconitate + H2O;;(1b) cis-aconitate + H2O = isocitrate | citrate(isocitrate) hydro-lyase (cis-aconitate-forming) | None | cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase | |
| 4.2.1.5 | arabinonate dehydratase | False | 1 | 17 | 0 | 1 | D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O | D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming) | None | D-arabinonate hydro-lyase | |
| 4.2.1.6 | galactonate dehydratase | False | 48 | 5118 | 4 | 12 | D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O | D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming) | None | D-galactonate dehydrase; D-galactonate dehydratase; D-galactonate hydro-lyase | |
| 4.2.1.7 | altronate dehydratase | False | 2 | 1317 | 0 | 1 | D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O | D-altronate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming) | None | D-altronate hydro-lyase | |
| 4.2.1.8 | mannonate dehydratase | False | 146 | 15468 | 13 | 6 | D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O | D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming) | None | mannonic hydrolase; mannonate hydrolyase; altronic hydro-lyase; altronate hydrolase; D-mannonate hydrolyase; D-mannonate hydro-lyase | |
| 4.2.1.9 | dihydroxy-acid dehydratase | False | 582 | 50606 | 8 | 23 | 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O | 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming) | None | acetohydroxyacid dehydratase; alpha,beta-dihydroxyacid dehydratase; 2,3-dihydroxyisovalerate dehydratase; alpha,beta-dihydroxyisovalerate dehydratase; dihydroxy acid dehydrase; DHAD; 2,3-dihydroxy-acid hydro-lyase | |
| 4.2.1.10 | 3-dehydroquinate dehydratase | False | 617 | 46609 | 122 | 60 | 3-dehydroquinate = 3-dehydroshikimate + H2O | 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming) | None | 3-dehydroquinate hydrolase; DHQase; dehydroquinate dehydratase; 3-dehydroquinase; 5-dehydroquinase; dehydroquinase; 5-dehydroquinate dehydratase; 5-dehydroquinate hydro-lyase; 3-dehydroquinate hydro-lyase | |
| 4.2.1.11 | phosphopyruvate hydratase | False | 919 | 67707 | 108 | 114 | 2-phospho-D-glycerate = phosphoenolpyruvate + H2O | 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming) | None | enolase; 2-phosphoglycerate dehydratase; 14-3-2-protein; nervous-system specific enolase; phosphoenolpyruvate hydratase; 2-phosphoglycerate dehydratase; 2-phosphoglyceric dehydratase; 2-phosphoglycerate enolase; gamma-enolase; 2-phospho-D-glycerate hydro-lyase | |
| 4.2.1.12 | phosphogluconate dehydratase | False | 7 | 9972 | 1 | 25 | 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O | 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming) | None | 6-phosphogluconate dehydratase; 6-phosphogluconic dehydrase; gluconate-6-phosphate dehydratase; gluconate 6-phosphate dehydratase; 6-phosphogluconate dehydrase; 6-phospho-D-gluconate hydro-lyase | |
| 4.2.1.17 | enoyl-CoA hydratase | False | 259 | 57243 | 95 | 19 | (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O | (3S)-3-hydroxyacyl-CoA hydro-lyase | None | enoyl hydrase; unsaturated acyl-CoA hydratase; beta-hydroxyacyl-CoA dehydrase; beta-hydroxyacid dehydrase; acyl coenzyme A hydrase; crotonase; crotonyl hydrase; 2-octenoyl coenzyme A hydrase; enoyl coenzyme A hydratase; 2-enoyl-CoA hydratase; short-chain enoyl-CoA hydratase; ECH; trans-2-enoyl-CoA hydratase; enoyl coenzyme A hydrase (D); enoyl coenzyme A hydrase (L); short chain enoyl coenzyme A hydratase; D-3-hydroxyacyl-CoA dehydratase; enol-CoA hydratase | |
| 4.2.1.18 | methylglutaconyl-CoA hydratase | False | 4 | 661 | 2 | 9 | (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O | (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming) | None | methylglutaconyl coenzyme A hydratase; 3-methylglutaconyl CoA hydratase; methylglutaconase; (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase | |
| 4.2.1.19 | imidazoleglycerol-phosphate dehydratase | False | 558 | 35852 | 30 | 16 | D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O | D-erythro-1-(imidazol-4-yl)glycerol-3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming] | None | IGP dehydratase; D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase | |
| 4.2.1.20 | tryptophan synthase | False | 1002 | 94371 | 202 | 33 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O (overall reaction);;(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate;;(1b) L-serine + indole = L-tryptophan + H2O | L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate, L-tryptophan and D-glyceraldehyde-3-phosphate-forming] | None | L-tryptophan synthetase; indoleglycerol phosphate aldolase; tryptophan desmolase; tryptophan synthetase; L-serine hydro-lyase (adding indoleglycerol-phosphate); L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate, L-tryptophan and glyceraldehyde-3-phosphate-forming] | |
| 4.2.1.22 | cystathionine beta-synthase | False | 13 | 8839 | 46 | 45 | L-serine + L-homocysteine = L-cystathionine + H2O | L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) | None | serine sulfhydrase; beta-thionase; methylcysteine synthase; cysteine synthase (incorrect); serine sulfhydrylase; L-serine hydro-lyase (adding homocysteine) | |
| 4.2.1.24 | porphobilinogen synthase | False | 58 | 39864 | 43 | 77 | 2 5-aminolevulinate = porphobilinogen + 2 H2O | 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming) | None | aminolevulinate dehydratase; delta-aminolevulinate dehydratase; delta-aminolevulinic acid dehydrase; delta-aminolevulinic acid dehydratase; aminolevulinic dehydratase; delta-aminolevulinic dehydratase; 5-levulinic acid dehydratase; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing); hemB (gene name) | |
| 4.2.1.25 | L-arabinonate dehydratase | False | 2 | 662 | 1 | 5 | L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O | L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming) | None | L-arabonate dehydrase; L-arabonate dehydratase; L-arabinonate hydro-lyase | |
| 4.2.1.27 | acetylenecarboxylate hydratase | True | 0 | 0 | 0 | 1 | 3-oxopropanoate = propynoate + H2O | 3-oxopropanoate hydro-lyase (propynoate-forming) | None | acetylenemonocarboxylate hydratase; alkynoate hydratase; acetylenemonocarboxylate hydrase; acetylenemonocarboxylic acid hydrase; malonate-semialdehyde dehydratase; 3-oxopropanoate hydro-lyase | |
| 4.2.1.28 | propanediol dehydratase | False | 6 | 641 | 13 | 15 | propane-1,2-diol = propanal + H2O | propane-1,2-diol hydro-lyase (propanal-forming) | None | meso-2,3-butanediol dehydrase; diol dehydratase; DL-1,2-propanediol hydro-lyase; diol dehydrase; adenosylcobalamin-dependent diol dehydratase; propanediol dehydrase; coenzyme B12-dependent diol dehydrase; 1,2-propanediol dehydratase; dioldehydratase; propane-1,2-diol hydro-lyase; RiDD | |
| 4.2.1.30 | glycerol dehydratase | False | 1 | 351 | 2 | 14 | glycerol = 3-hydroxypropanal + H2O | glycerol hydro-lyase (3-hydroxypropanal-forming) | None | glycerol dehydrase; glycerol hydro-lyase; dhaB (gene name) | |
| 4.2.1.31 | maleate hydratase | False | 2 | 5 | 0 | 31 | (R)-malate = maleate + H2O | (R)-malate hydro-lyase (maleate-forming) | None | D-malate hydro-lyase; malease; (R)-malate hydro-lyase | |
| 4.2.1.32 | L(+)-tartrate dehydratase | False | 18 | 11636 | 1 | 9 | (R,R)-tartrate = oxaloacetate + H2O | (R,R)-tartrate hydro-lyase (oxaloacetate-forming) | None | tartrate dehydratase; tartaric acid dehydrase; L-tartrate dehydratase; L-(+)-tartaric acid dehydratase; (R,R)-tartrate hydro-lyase | |
| 4.2.1.33 | 3-isopropylmalate dehydratase | False | 1078 | 84470 | 9 | 12 | (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate (overall reaction);;(1a) (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O;;(1b) 2-isopropylmaleate + H2O = (2S)-2-isopropylmalate | (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming) | None | (2R,3S)-3-isopropylmalate hydro-lyase; beta-isopropylmalate dehydratase; isopropylmalate isomerase; alpha-isopropylmalate isomerase; 3-isopropylmalate hydro-lyase | |
| 4.2.1.34 | (S)-2-methylmalate dehydratase | True | 0 | 0 | 0 | 10 | (S)-2-methylmalate = 2-methylfumarate + H2O | (S)-2-methylmalate hydro-lyase (2-methylfumarate-forming) | None | mesaconate hydratase; (+)-citramalate hydro-lyase; L-citramalate hydrolase; citramalate dehydratase; (+)-citramalic hydro-lyase; mesaconate mesaconase; mesaconase; (S)-2-methylmalate hydro-lyase | |
| 4.2.1.35 | (R)-2-methylmalate dehydratase | False | 2 | 151 | 0 | 2 | (R)-2-methylmalate = 2-methylmaleate + H2O | (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming) | None | citraconate hydratase; citraconase; citramalate hydro-lyase; (-)-citramalate hydro-lyase; (R)-2-methylmalate hydro-lyase | |
| 4.2.1.36 | homoaconitate hydratase | False | 21 | 1993 | 1 | 10 | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming] | None | homoaconitase; cis-homoaconitase; HACN; Lys4; LysF; 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase (incorrect) | |
| 4.2.1.39 | gluconate dehydratase | False | 11 | 197 | 0 | 24 | D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O | D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming) | None | D-gluconate dehydratase; D-gluconate hydro-lyase | |
| 4.2.1.40 | glucarate dehydratase | False | 6 | 9654 | 13 | 12 | D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O | D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming) | None | D-glucarate dehydratase; D-glucarate hydro-lyase | |
| 4.2.1.41 | 5-dehydro-4-deoxyglucarate dehydratase | False | 59 | 5872 | 3 | 7 | 5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2 | 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming) | None | 5-keto-4-deoxy-glucarate dehydratase; 5-keto-4-deoxy-glucarate dehydratase; deoxyketoglucarate dehydratase; D-4-deoxy-5-ketoglucarate hydro-lyase; 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating) | |
| 4.2.1.42 | galactarate dehydratase | False | 3 | 4648 | 2 | 4 | galactarate = (2R,3S)-2,3-dihydroxy-5-oxohexanedioate + H2O | galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming) | None | D-galactarate hydro-lyase; D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming); talrD (gene name)/galrD (gene name); galactarate dehydratase (L-threo-forming) | |
| 4.2.1.43 | 2-dehydro-3-deoxy-L-arabinonate dehydratase | False | 1 | 255 | 3 | 5 | 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O | 2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming) | None | 2-keto-3-deoxy-L-arabinonate dehydratase; 2-dehydro-3-deoxy-L-arabinonate hydro-lyase | |
| 4.2.1.44 | myo-inosose-2 dehydratase | False | 38 | 5022 | 0 | 1 | 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O | 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming) | None | inosose 2,3-dehydratase; ketoinositol dehydratase; 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase | |
| 4.2.1.45 | CDP-glucose 4,6-dehydratase | False | 1 | 3500 | 2 | 3 | CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O | CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming) | None | cytidine diphosphoglucose oxidoreductase; CDP-glucose 4,6-hydro-lyase | |
| 4.2.1.46 | dTDP-glucose 4,6-dehydratase | False | 27 | 37478 | 19 | 30 | dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O | dTDP-alpha-D-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-alpha-D-glucose-forming) | None | thymidine diphosphoglucose oxidoreductase; TDP-glucose oxidoreductase; dTDP-glucose 4,6-hydro-lyase; dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-alpha-D-glucose-forming) | |
| 4.2.1.47 | GDP-mannose 4,6-dehydratase | False | 22 | 32045 | 15 | 24 | GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O | GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming) | None | guanosine 5'-diphosphate-D-mannose oxidoreductase; guanosine diphosphomannose oxidoreductase; guanosine diphosphomannose 4,6-dehydratase; GDP-D-mannose dehydratase; GDP-D-mannose 4,6-dehydratase; Gmd; GDP-mannose 4,6-hydro-lyase; GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming) | |
| 4.2.1.48 | D-glutamate cyclase | False | 2 | 4 | 0 | 5 | D-glutamate = 5-oxo-D-proline + H2O | D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming) | None | D-glutamate hydro-lyase (cyclizing) | |
| 4.2.1.49 | urocanate hydratase | False | 170 | 23474 | 8 | 17 | 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O | 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming) | None | urocanase; 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase | |
| 4.2.1.50 | pyrazolylalanine synthase | False | 1 | 2 | 0 | 4 | L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O | L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming] | None | beta-pyrazolylalaninase; beta-(1-pyrazolyl)alanine synthase; L-serine hydro-lyase (adding pyrazole) | |
| 4.2.1.51 | prephenate dehydratase | False | 44 | 38727 | 11 | 28 | prephenate = phenylpyruvate + H2O + CO2 | prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) | None | prephenate hydro-lyase (decarboxylating) | |
| 4.2.1.53 | oleate hydratase | False | 3 | 2118 | 1 | 19 | (R)-10-hydroxystearate = oleate + H2O | (R)-10-hydroxystearate 10-hydro-lyase (oleate-forming) | None | (R)-10-hydroxystearate 10-hydro-lyase | |
| 4.2.1.54 | lactoyl-CoA dehydratase | False | 2 | 4 | 0 | 8 | (R)-lactoyl-CoA = acryloyl-CoA + H2O | (R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming) | None | lactoyl coenzyme A dehydratase; lactyl-coenzyme A dehydrase; lactyl CoA dehydratase; acrylyl coenzyme A hydratase; lactoyl-CoA hydro-lyase | |
| 4.2.1.55 | 3-hydroxybutyryl-CoA dehydratase | False | 3 | 759 | 3 | 6 | (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O | (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming) | None | D-3-hydroxybutyryl coenzyme A dehydratase; D-3-hydroxybutyryl-CoA dehydratase; enoyl coenzyme A hydrase (D); (3R)-3-hydroxybutanoyl-CoA hydro-lyase | |
| 4.2.1.56 | itaconyl-CoA hydratase | False | 3 | 34 | 0 | 5 | citramalyl-CoA = itaconyl-CoA + H2O | citramalyl-CoA hydro-lyase (itaconyl-CoA-forming) | None | itaconyl coenzyme A hydratase; citramalyl-CoA hydro-lyase | |
| 4.2.1.57 | isohexenylglutaconyl-CoA hydratase | False | 0 | 47 | 0 | 2 | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming] | None | 3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase; isohexenylglutaconyl coenzyme A hydratase; beta-isohexenylglutaconyl-CoA-hydratase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase | |
| 4.2.1.134 | very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase | False | 24 | 8881 | 0 | 5 | a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H2O | very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase | None | PHS1 (gene name); PAS2 (gene name) | |
| 4.2.1.152 | hydroperoxy icosatetraenoate dehydratase | False | 44 | 1266 | 0 | 2 | a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O | hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming) | None | epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous) | |
| 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | False | 783 | 39760 | 26 | 4 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O | (3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming) | None | fabZ (gene name); fabA (gene name); D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase; D-3-hydroxyoctanoyl-acyl carrier protein dehydratase; beta-hydroxyoctanoyl-acyl carrier protein dehydrase; beta-hydroxyoctanoyl thioester dehydratase; beta-hydroxyoctanoyl-ACP-dehydrase; (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase; (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming); 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase | |
| 4.2.1.62 | 5alpha-hydroxysteroid dehydratase | True | 0 | 0 | 0 | 1 | 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O | 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming) | None | 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase | |
| 4.2.1.65 | 3-cyanoalanine hydratase | False | 4 | 3 | 0 | 4 | L-asparagine = 3-cyanoalanine + H2O | L-asparagine hydro-lyase (3-cyanoalanine-forming) | None | beta-cyanoalanine hydrolase; beta-cyanoalanine hydratase; beta-CNAla hydrolase; beta-CNA nitrilase; L-asparagine hydro-lyase | |
| 4.2.1.66 | cyanide hydratase | False | 14 | 485 | 0 | 23 | formamide = cyanide + H2O | formamide hydro-lyase (cyanide-forming) | None | formamide dehydratase; formamide hydro-lyase | |
| 4.2.1.67 | D-fuconate dehydratase | False | 1 | 4 | 0 | 1 | D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O | D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming) | None | D-fuconate hydro-lyase | |
| 4.2.1.68 | L-fuconate dehydratase | False | 5 | 5063 | 1 | 4 | L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O | L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming) | None | L-fuconate hydro-lyase | |
| 4.2.1.69 | cyanamide hydratase | False | 22 | 164 | 1 | 3 | urea = cyanamide + H2O | urea hydro-lyase (cyanamide-forming) | None | urea hydro-lyase | |
| 4.2.1.70 | pseudouridylate synthase | False | 58 | 9016 | 25 | 14 | uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O | uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming) | None | pseudouridylic acid synthetase; pseudouridine monophosphate synthetase; 5-ribosyluracil 5-phosphate synthetase; pseudouridylate synthetase; upsilonUMP synthetase; uracil hydro-lyase (adding D-ribose 5-phosphate); YeiN; pseudouridine-5'-phosphate glycosidase | |
| 4.2.1.73 | protoaphin-aglucone dehydratase (cyclizing) | True | 0 | 0 | 0 | 4 | protoaphin aglucone = xanthoaphin + H2O | protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming) | None | protoaphin dehydratase; protoaphin dehydratase (cyclizing); protoaphin-aglucone hydro-lyase (cyclizing) | |
| 4.2.1.74 | medium-chain-enoyl-CoA hydratase | True | 0 | 0 | 0 | 3 | a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain trans-2-enoyl-CoA + H2O | medium-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase | None | long-chain enoyl coenzyme A hydratase (incorrect); long-chain-enoyl-CoA hydratase (incorrect); long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase (incorrect) | |
| 4.2.1.75 | uroporphyrinogen-III synthase | False | 18 | 24821 | 10 | 18 | hydroxymethylbilane = uroporphyrinogen III + H2O | hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming) | None | porphobilinogenase; uroporphyrinogen isomerase; uroporphyrinogen III cosynthase; URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing) | |
| 4.2.1.76 | UDP-glucose 4,6-dehydratase | False | 3 | 21 | 0 | 7 | UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O | UDP-alpha-D-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-alpha-D-glucose-forming) | None | UDP-D-glucose-4,6-hydrolyase; UDP-D-glucose oxidoreductase; UDP-glucose 4,6-hydro-lyase | |
| 4.2.1.77 | trans-L-3-hydroxyproline dehydratase | False | 23 | 1760 | 1 | 6 | trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O | trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming) | None | trans-L-3-hydroxyproline hydro-lyase | |
| 4.2.1.79 | 2-methylcitrate dehydratase | False | 12 | 5324 | 3 | 12 | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] | None | 2-methylcitrate hydro-lyase; PrpD; 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase | |
| 4.2.1.80 | 2-oxopent-4-enoate hydratase | False | 24 | 1840 | 2 | 7 | (S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O | (S)-4-hydroxy-2-oxopentanoate hydro-lyase ((2Z)-2-hydroxypenta-2,4-dienoate-forming) | None | 2-keto-4-pentenoate hydratase; OEH; 2-keto-4-pentenoate (vinylpyruvate)hydratase; 4-hydroxy-2-oxopentanoate hydro-lyase; 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming); mhpD (gene name); ahdF (gene name); todG (gene name); cmtF (gene name); xylJ (gene name); cnbE (gene name) | |
| 4.2.1.81 | D(-)-tartrate dehydratase | False | 2 | 69 | 2 | 3 | (S,S)-tartrate = oxaloacetate + H2O | (S,S)-tartrate hydro-lyase (oxaloacetate-forming) | None | D-tartrate dehydratase; (S,S)-tartrate hydro-lyase | |
| 4.2.1.82 | xylonate dehydratase | False | 4 | 390 | 0 | 4 | D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O | D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming) | None | D-xylo-aldonate dehydratase; D-xylonate dehydratase; D-xylonate hydro-lyase | |
| 4.2.1.83 | 4-oxalomesaconate hydratase | False | 1 | 454 | 4 | 4 | 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + H2O | (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate 1,2-hydro-lyase (2-hydroxy-4-oxobutane-1,2,4-tricarboxylate-forming) | None | 4-oxalmesaconate hydratase; 4-carboxy-2-oxohexenedioate hydratase; 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase; oxalmesaconate hydratase; gamma-oxalmesaconate hydratase; 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase; LigJ; GalB | |
| 4.2.1.84 | nitrile hydratase | False | 15 | 7682 | 58 | 50 | an aliphatic amide = a nitrile + H2O | aliphatic-amide hydro-lyase (nitrile-forming) | None | nitrilase (ambiguous); 3-cyanopyridine hydratase; NHase; L-NHase; H-NHase; acrylonitrile hydratase; aliphatic nitrile hydratase; nitrile hydro-lyase | |
| 4.2.1.85 | dimethylmaleate hydratase | False | 2 | 395 | 0 | 1 | (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O | (2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming) | None | (2R,3S)-2,3-dimethylmalate hydro-lyase | |
| 4.2.1.87 | octopamine dehydratase | True | 0 | 0 | 0 | 1 | 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3 | 1-(4-hydroxyphenyl)-2-aminoethanol hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming] | None | octopamine hydrolyase; octopamine hydro-lyase (deaminating) | |
| 4.2.1.88 | synephrine dehydratase | True | 0 | 0 | 0 | 1 | (R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine | (R)-synephrine hydro-lyase (methylamine-forming) | None | syringinase | |
| 4.2.1.90 | L-rhamnonate dehydratase | False | 47 | 1533 | 4 | 9 | L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O | L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming) | None | L-rhamnonate hydro-lyase | |
| 4.2.1.91 | arogenate dehydratase | False | 10 | 2091 | 0 | 12 | L-arogenate = L-phenylalanine + H2O + CO2 | L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming) | None | carboxycyclohexadienyl dehydratase; L-arogenate hydro-lyase (decarboxylating) | |
| 4.2.1.92 | hydroperoxide dehydratase | False | 10 | 49 | 12 | 45 | (9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O | (9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate 12,13-hydro-lyase [(9Z,15Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate-forming] | None | hydroperoxide isomerase; linoleate hydroperoxide isomerase; linoleic acid hydroperoxide isomerase; HPI; (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase; (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]; allene oxide synthase; AOS | |
| 4.2.1.93 | ATP-dependent NAD(P)H-hydrate dehydratase | False | 42 | 4360 | 27 | 7 | (1) ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH;;(2) ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming) | None | reduced nicotinamide adenine dinucleotide hydrate dehydratase; ATP-dependent H4NAD(P)+OH dehydratase; (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing); (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming) | |
| 4.2.1.94 | scytalone dehydratase | False | 4 | 23 | 8 | 11 | scytalone = 1,3,8-trihydroxynaphthalene + H2O | scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) | None | scytalone 7,8-hydro-lyase | |
| 4.2.1.95 | kievitone hydratase | False | 1 | 0 | 0 | 2 | kievitone hydrate = kievitone + H2O | kievitone-hydrate hydro-lyase (kievitone-forming) | None | KHase; kievitone-hydrate hydro-lyase | |
| 4.2.1.96 | 4a-hydroxytetrahydrobiopterin dehydratase | False | 258 | 32114 | 11 | 10 | 4a-hydroxytetrahydrobiopterin = 6,7-dihydrobiopterin + H2O | 4a-hydroxytetrahydrobiopterin hydro-lyase (6,7-dihydrobiopterin-forming) | None | 4alpha-hydroxy-tetrahydropterin dehydratase; 4a-carbinolamine dehydratase; pterin-4alpha-carbinolamine dehydratase; 4a-hydroxytetrahydrobiopterin hydro-lyase | |
| 4.2.1.97 | phaseollidin hydratase | True | 0 | 0 | 0 | 1 | phaseollidin hydrate = phaseollidin + H2O | phaseollidin-hydrate hydro-lyase (phaseollidin-forming) | None | phaseollidin-hydrate hydro-lyase | |
| 4.2.1.98 | 16alpha-hydroxyprogesterone dehydratase | True | 0 | 0 | 0 | 1 | 16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O | 16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming) | None | hydroxyprogesterone dehydroxylase; 16alpha-hydroxyprogesterone dehydroxylase; 16alpha-dehydroxylase; 16alpha-hydroxyprogesterone hydro-lyase | |
| 4.2.1.99 | 2-methylisocitrate dehydratase | False | 35 | 12046 | 0 | 2 | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] | None | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase | |
| 4.2.1.100 | cyclohexa-1,5-dienecarbonyl-CoA hydratase | False | 1 | 169 | 0 | 6 | 6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O | 6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming) | None | cyclohexa-1,5-diene-1-carbonyl-CoA hydratase; dienoyl-CoA hydratase; cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect); 6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming) | |
| 4.2.1.103 | cyclohexyl-isocyanide hydratase | False | 1 | 693 | 9 | 3 | N-cyclohexylformamide = cyclohexyl isocyanide + H2O | N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming) | None | isonitrile hydratase; N-cyclohexylformamide hydro-lyase | |
| 4.2.1.104 | cyanase | False | 124 | 6845 | 17 | 17 | cyanate + hydrogencarbonate + 2 H+ = NH3 + 2 CO2 (overall reaction);;(1a) cyanate + hydrogencarbonate + H+ = carbamate + CO2;;(1b) carbamate + H+ = NH3 + CO2 (spontaneous) | carbamate hydro-lyase | None | cyanate lyase; cyanate hydrolase; cyanate aminohydrolase; cyanate C-N-lyase; cyanate hydratase | |
| 4.2.1.105 | 2-hydroxyisoflavanone dehydratase | False | 2 | 65 | 1 | 4 | (1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O;;(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O | 2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming) | None | 2,7,4'-trihydroxyisoflavanone hydro-lyase; 2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) | |
| 4.2.1.106 | bile-acid 7alpha-dehydratase | False | 1 | 175 | 4 | 3 | 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O | 7alpha,12alpha-dihydroxy-3-oxochol-4-enoyl-CoA hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoyl-CoA-forming) | None | baiE (gene name); 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase; 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming); BA7 alpha dehydratase | |
| 4.2.1.107 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase | False | 3 | 116 | 2 | 2 | (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O | (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] | None | 46 kDa hydratase 2; (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase | |
| 4.2.2.1 | hyaluronate lyase | False | 7 | 322 | 37 | 42 | Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. | hyaluronate lyase | None | hyaluronidase (ambiguous); glucuronoglycosaminoglycan lyase (ambiguous); spreading factor; mucinase (ambiguous) | |
| 4.2.2.2 | pectate lyase | False | 113 | 15584 | 57 | 89 | Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends | (1->4)-alpha-D-galacturonan lyase | None | polygalacturonic transeliminase; pectic acid transeliminase; polygalacturonate lyase; endopectin methyltranseliminase; pectate transeliminase; endogalacturonate transeliminase; pectic acid lyase; pectic lyase; alpha-1,4-D-endopolygalacturonic acid lyase; PGA lyase; PPase-N; endo-alpha-1,4-polygalacturonic acid lyase; polygalacturonic acid lyase; pectin trans-eliminase; Polygalacturonic acid trans-eliminase | |
| 4.2.2.3 | mannuronate-specific alginate lyase | False | 26 | 1353 | 43 | 77 | Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end. | alginate beta-D-mannuronate---uronate lyase | None | alginate lyase I; alginate lyase; alginase I; alginase II; alginase; poly(beta-D-1,4-mannuronide) lyase; poly(beta-D-mannuronate) lyase; aly (gene name) (ambiguous); poly[(1->4)-beta-D-mannuronide] lyase | |
| 4.2.2.5 | chondroitin AC lyase | False | 1 | 124 | 11 | 10 | Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups | chondroitin AC lyase | None | chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC | |
| 4.2.2.6 | oligogalacturonide lyase | False | 2 | 145 | 0 | 4 | 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate | oligogalacturonide lyase | None | oligogalacturonate lyase; unsaturated oligogalacturonate transeliminase; OGTE | |
| 4.2.2.7 | heparin lyase | False | 3 | 87 | 3 | 15 | Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends | heparin lyase | None | heparin eliminase; heparinase | |
| 4.2.2.8 | heparin-sulfate lyase | False | 5 | 179 | 2 | 6 | Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. | heparin-sulfate lyase | None | heparin-sulfate eliminase; heparitin-sulfate lyase; heparitinase I; heparitinase II | |
| 4.2.2.9 | pectate disaccharide-lyase | False | 2 | 140 | 0 | 10 | (1,4-alpha-D-galacturonosyl)n = (1,4-alpha-D-galacturonosyl)n-2 + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate | (1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase | None | pectate exo-lyase; exopectic acid transeliminase; exopectate lyase; exopolygalacturonic acid-trans-eliminase; PATE; exo-PATE; exo-PGL; exopolygalacturonate lyase (ambiguous); pelW (gene name); pelX (gene name) | |
| 4.2.2.10 | pectin lyase | False | 46 | 3586 | 6 | 64 | Eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends | (1->4)-6-O-methyl-alpha-D-galacturonan lyase | None | pectin trans-eliminase; endo-pectin lyase; polymethylgalacturonic transeliminase; pectin methyltranseliminase; pectolyase; PL; PNL; PMGL | |
| 4.2.2.11 | guluronate-specific alginate lyase | False | 0 | 23 | 2 | 37 | Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end. | alginate alpha-L-guluronate---uronate lyase | None | alginase II; guluronate lyase; L-guluronan lyase; L-guluronate lyase; poly-alpha-L-guluronate lyase; polyguluronate-specific alginate lyase; poly(alpha-L-1,4-guluronide) exo-lyase; poly(alpha-L-guluronate) lyase; poly[(1->4)-alpha-L-guluronide] exo-lyase | |
| 4.2.2.12 | xanthan lyase | False | 1 | 325 | 8 | 5 | Eliminative cleavage of the terminal beta-D-mannosyl-(1->4)-beta-D-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain | xanthan lyase | None | None | |
| 4.2.2.13 | exo-(1->4)-alpha-D-glucan lyase | False | 0 | 0 | 5 | 7 | linear alpha-glucan = (n-1) 1,5-anhydro-D-fructose + D-glucose | (1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming) | None | alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase; alpha-1,4-glucan exo-lyase; alpha-1,4-glucan lyase; GLase | |
| 4.2.2.14 | glucuronan lyase | False | 1 | 0 | 1 | 3 | Eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides. | (1->4)-beta-D-glucuronan lyase | None | (1,4)-beta-D-glucuronan lyase | |
| 4.2.2.15 | anhydrosialidase | False | 1 | 2 | 1 | 3 | Elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate | glycoconjugate sialyl-lyase (2,7-cyclizing) | None | anhydroneuraminidase; sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing); sialidase L | |
| 4.2.2.16 | levan fructotransferase (DFA-IV-forming) | False | 0 | 0 | 4 | 6 | Produces di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide | (2->6)-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) | None | 2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride); levan fructotransferase; 2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) | |
| 4.2.2.17 | inulin fructotransferase (DFA-I-forming) | False | 1 | 63 | 2 | 7 | Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. | (2->1)-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) | None | inulin fructotransferase (DFA-I-producing); inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming); inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming); inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride); 2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) | |
| 4.2.2.18 | inulin fructotransferase (DFA-III-forming) | False | 0 | 4 | 4 | 14 | Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. | (2->1)-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) | None | inulin fructotransferase (DFA-III-producing); inulin fructotransferase (depolymerizing); inulase II; inulinase II; inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming); inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming); inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride); 2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) | |
| 4.2.2.19 | chondroitin B lyase | False | 1 | 60 | 0 | 2 | Eliminative cleavage of dermatan sulfate containing (1->4)-beta-D-hexosaminyl and (1->3)-beta-D-glucurosonyl or (1->3)-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAc-4S). | chondroitin B lyase | None | chondroitinase B; ChonB; ChnB | |
| 4.2.3.1 | threonine synthase | False | 28 | 45250 | 15 | 20 | O-phospho-L-homoserine + H2O = L-threonine + phosphate | O-phospho-L-homoserine phosphate-lyase (adding water; L-threonine-forming) | None | threonine synthetase; O-phospho-L-homoserine phospho-lyase (adding water) | |
| 4.2.3.2 | ethanolamine-phosphate phospho-lyase | False | 5 | 1089 | 3 | 9 | ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate | ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming) | None | O-phosphoethanolamine-phospholyase; amino alcohol O-phosphate phospholyase; O-phosphorylethanol-amine phospho-lyase; ethanolamine-phosphate phospho-lyase (deaminating) | |
| 4.2.3.3 | methylglyoxal synthase | False | 228 | 12229 | 10 | 25 | glycerone phosphate = 2-oxopropanal + phosphate | glycerone-phosphate phosphate-lyase (methylglyoxal-forming) | None | methylglyoxal synthetase; glycerone-phosphate phospho-lyase | |
| 4.2.3.4 | 3-dehydroquinate synthase | False | 589 | 38953 | 31 | 31 | 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate | 3-deoxy-D-arabino-hept-2-ulosonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming) | None | 5-dehydroquinate synthase; 5-dehydroquinic acid synthetase; dehydroquinate synthase; 3-dehydroquinate synthetase; 3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing); 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing); 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming) | |
| 4.2.3.5 | chorismate synthase | False | 714 | 44498 | 21 | 27 | 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate | 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming) | None | 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase | |
| 4.2.3.6 | trichodiene synthase | False | 18 | 112 | 16 | 14 | (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming) | None | trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase | |
| 4.2.3.7 | pentalenene synthase | False | 4 | 12 | 13 | 2 | (2E,6E)-farnesyl diphosphate = pentalenene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming) | None | pentalenene synthetase | |
| 4.2.3.8 | casbene synthase | False | 1 | 10 | 0 | 5 | geranylgeranyl diphosphate = casbene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming) | None | casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing) | |
| 4.2.3.9 | aristolochene synthase | False | 5 | 7 | 20 | 4 | (2E,6E)-farnesyl diphosphate = aristolochene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming) | None | sesquiterpene cyclase; trans,trans-farnesyl diphosphate aristolochene-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming) | |
| 4.2.3.10 | (-)-endo-fenchol synthase | False | 4 | 0 | 0 | 3 | geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming] | None | (-)-endo-fenchol cyclase; geranyl pyrophosphate:(-)-endo-fenchol cyclase | |
| 4.2.3.11 | sabinene-hydrate synthase | False | 2 | 2 | 0 | 5 | geranyl diphosphate + H2O = sabinene hydrate + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming) | None | sabinene hydrate cyclase | |
| 4.2.3.12 | 6-pyruvoyltetrahydropterin synthase | False | 9 | 2260 | 10 | 18 | 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate | 7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming) | None | 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase; 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming) | |
| 4.2.3.13 | (+)-delta-cadinene synthase | False | 8 | 280 | 2 | 8 | (2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming) | None | None | |
| 4.2.3.15 | myrcene synthase | False | 35 | 10 | 0 | 9 | geranyl diphosphate = myrcene + diphosphate | geranyl-diphosphate diphosphate-lyase (myrcene-forming) | None | None | |
| 4.2.3.16 | (4S)-limonene synthase | False | 10 | 2 | 0 | 10 | geranyl diphosphate = (S)-limonene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing; (S)-limonene-forming] | None | (-)-(4S)-limonene synthase; 4S-(-)-limonene synthase; geranyldiphosphate diphosphate lyase (limonene forming); geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing; (-)-(4S)-limonene-forming] | |
| 4.2.3.17 | taxadiene synthase | False | 3 | 2 | 2 | 10 | geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing; taxa-4,11-diene-forming) | None | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming) | |
| 4.2.3.18 | abieta-7,13-diene synthase | False | 6 | 1 | 1 | 7 | (+)-copalyl diphosphate = abieta-7,13-diene + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase [cyclizing, abieta-7,13-diene-forming] | None | copalyl-diphosphate diphosphate-lyase (cyclizing) (ambiguous); abietadiene synthase (ambiguous) | |
| 4.2.3.19 | ent-kaurene synthase | False | 14 | 78 | 0 | 26 | ent-copalyl diphosphate = ent-kaurene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming) | None | ent-kaurene synthase B; ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase (cyclizing) | |
| 4.2.3.20 | (R)-limonene synthase | False | 5 | 18 | 1 | 9 | geranyl diphosphate = (R)-limonene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (R)-limonene-forming] | None | (+)-limonene synthase; geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] | |
| 4.2.3.21 | vetispiradiene synthase | False | 4 | 9 | 1 | 3 | (2E,6E)-farnesyl diphosphate = vetispiradiene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) | None | vetispiradiene-forming farnesyl pyrophosphate cyclase; pemnaspirodiene synthase; HVS; vetispiradiene cyclase | |
| 4.2.99.12 | carboxymethyloxysuccinate lyase | True | 0 | 0 | 0 | 1 | carboxymethyloxysuccinate = fumarate + glycolate | carboxymethyloxysuccinate glycolate-lyase (fumarate-forming) | None | carbon-oxygen lyase; carboxymethyloxysuccinate glycolate-lyase | |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | False | 611 | 111249 | 165 | 42 | The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate | DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase | None | AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); deoxyribonuclease (apurinic or apyrimidinic); E. coli endonuclease III; phage-T4 UV endonuclease; Micrococcus luteus UV endonuclease; AP site-DNA 5'-phosphomonoester-lyase; X-ray endonuclease III | |
| 4.3.1.1 | aspartate ammonia-lyase | False | 14 | 11112 | 8 | 21 | L-aspartate = fumarate + NH3 | L-aspartate ammonia-lyase (fumarate-forming) | None | aspartase; fumaric aminase; L-aspartase; L-aspartate ammonia-lyase | |
| 4.3.1.2 | methylaspartate ammonia-lyase | False | 5 | 1427 | 6 | 10 | L-threo-3-methylaspartate = mesaconate + NH3 | L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming) | None | beta-methylaspartase; 3-methylaspartase; L-threo-3-methylaspartate ammonia-lyase | |
| 4.3.1.3 | histidine ammonia-lyase | False | 201 | 22177 | 14 | 30 | L-histidine = urocanate + NH3 | L-histidine ammonia-lyase (urocanate-forming) | None | histidase; histidinase; histidine alpha-deaminase; L-histidine ammonia-lyase | |
| 4.3.1.4 | formimidoyltetrahydrofolate cyclodeaminase | False | 6 | 4024 | 1 | 11 | 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 | 5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming) | None | formiminotetrahydrofolate cyclodeaminase; 5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing) | |
| 4.3.1.6 | beta-alanyl-CoA ammonia-lyase | False | 0 | 12 | 0 | 1 | beta-alanyl-CoA = acryloyl-CoA + NH3 | beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming) | None | beta-alanyl coenzyme A ammonia-lyase | |
| 4.3.1.7 | ethanolamine ammonia-lyase | False | 78 | 13978 | 11 | 8 | ethanolamine = acetaldehyde + NH3 | ethanolamine ammonia-lyase (acetaldehyde-forming) | None | ethanolamine deaminase | |
| 4.3.1.9 | glucosaminate ammonia-lyase | False | 1 | 38 | 0 | 3 | 2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH3 (overall reaction);;(1a) 2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O;;(1b) (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate (spontaneous);;(1c) (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH3 (spontaneous) | 2-amino-2-deoxy-D-gluconate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming) | None | glucosaminic dehydrase; D-glucosaminate dehydratase; D-glucosaminic acid dehydrase; aminodeoxygluconate dehydratase; 2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating); aminodeoxygluconate ammonia-lyase; 2-amino-2-deoxy-D-gluconate ammonia-lyase; D-glucosaminate ammonia-lyase; D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming) | |
| 4.3.1.10 | serine-sulfate ammonia-lyase | True | 0 | 0 | 0 | 13 | L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate | L-serine-O-sulfate ammonia-lyase (pyruvate-forming) | None | (L-SOS)lyase | |
| 4.3.1.12 | ornithine cyclodeaminase | False | 8 | 4078 | 10 | 13 | L-ornithine = L-proline + NH3 | L-ornithine ammonia-lyase (cyclizing; L-proline-forming) | None | ornithine cyclase; ornithine cyclase (deaminating); L-ornithine ammonia-lyase (cyclizing) | |
| 4.3.1.13 | carbamoyl-serine ammonia-lyase | True | 0 | 0 | 0 | 1 | O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2 (overall reaction);;(1a) O-carbamoyl-L-serine = CO2 + NH3 + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming) | None | O-carbamoyl-L-serine deaminase; carbamoylserine deaminase; O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming) | |
| 4.3.1.14 | 3-aminobutyryl-CoA ammonia-lyase | False | 2 | 180 | 0 | 4 | L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3 | L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming) | None | L-3-aminobutyryl-CoA deaminase; L-3-aminobutyryl-CoA ammonia-lyase | |
| 4.3.1.15 | diaminopropionate ammonia-lyase | False | 4 | 3152 | 6 | 6 | 2,3-diaminopropanoate + H2O = pyruvate + 2 NH3 | 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) | None | diaminopropionatase; alpha,beta-diaminopropionate ammonia-lyase; 2,3-diaminopropionate ammonia-lyase; 2,3-diaminopropanoate ammonia-lyase; 2,3-diaminopropanoate ammonia-lyase (adding H2O; pyruvate-forming) | |
| 4.3.1.16 | threo-3-hydroxy-L-aspartate ammonia-lyase | False | 2 | 1291 | 0 | 2 | threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 | threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming) | None | L-threo-3-hydroxyaspartate dehydratase; threo-3-hydroxyaspartate ammonia-lyase | |
| 4.3.1.17 | L-serine ammonia-lyase | False | 50 | 38238 | 8 | 31 | L-serine = pyruvate + NH3 (overall reaction);;(1a) L-serine = 2-aminoprop-2-enoate + H2O;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-serine ammonia-lyase (pyruvate-forming) | None | serine deaminase; L-hydroxyaminoacid dehydratase; L-serine deaminase; L-serine dehydratase; L-serine hydro-lyase (deaminating) | |
| 4.3.1.18 | D-serine ammonia-lyase | False | 121 | 4377 | 10 | 11 | D-serine = pyruvate + NH3 (overall reaction);;(1a) D-serine = 2-aminoprop-2-enoate + H2O;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | D-serine ammonia-lyase (pyruvate-forming) | None | D-hydroxyaminoacid dehydratase; D-serine dehydrase; D-hydroxy amino acid dehydratase; D-serine hydrolase; D-serine dehydratase (deaminating); D-serine deaminase; D-serine hydro-lyase (deaminating) | |
| 4.3.1.19 | threonine ammonia-lyase | False | 60 | 36675 | 8 | 56 | L-threonine = 2-oxobutanoate + NH3 (overall reaction);;(1a) L-threonine = 2-aminobut-2-enoate + H2O;;(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);;(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) | L-threonine ammonia-lyase (2-oxobutanoate-forming) | None | threonine deaminase; L-serine dehydratase; serine deaminase; L-threonine dehydratase; threonine dehydrase; L-threonine deaminase; threonine dehydratase; L-threonine hydro-lyase (deaminating); L-threonine ammonia-lyase | |
| 4.3.1.20 | erythro-3-hydroxy-L-aspartate ammonia-lyase | True | 0 | 0 | 0 | 2 | erythro-3-hydroxy-L-aspartate = oxaloacetate + NH3 | erythro-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming) | None | erythro-beta-hydroxyaspartate dehydratase; erythro-3-hydroxyaspartate dehydratase; erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating); erythro-3-hydroxy-Ls-aspartate ammonia-lyase | |
| 4.3.2.1 | argininosuccinate lyase | False | 621 | 41050 | 20 | 26 | 2-(Nomega-L-arginino)succinate = fumarate + L-arginine | 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming) | None | arginosuccinase; argininosuccinic acid lyase; arginine-succinate lyase; N-(L-argininosuccinate) arginine-lyase; omega-N-(L-arginino)succinate arginine-lyase; 2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming) | |
| 4.3.2.2 | adenylosuccinate lyase | False | 47 | 45150 | 33 | 21 | (1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP;;(2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | None | adenylosuccinase; succino AMP-lyase; 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase; 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | |
| 4.3.2.3 | ureidoglycolate lyase | False | 80 | 6034 | 0 | 19 | (S)-ureidoglycolate = glyoxylate + urea | (S)-ureidoglycolate urea-lyase (glyoxylate-forming) | None | ureidoglycolatase (ambiguous); ureidoglycolase (ambiguous); ureidoglycolate hydrolase (misleading); (S)-ureidoglycolate urea-lyase | |
| 4.3.2.4 | purine imidazole-ring cyclase | True | 0 | 0 | 0 | 5 | DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O | DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming) | None | DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing); DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming) | |
| 4.3.2.5 | peptidylamidoglycolate lyase | False | 10 | 1418 | 2 | 6 | [peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate | [peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming) | None | alpha-hydroxyglycine amidating dealkylase; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; HGAD; PGL; PAL; peptidylamidoglycolate peptidylamide-lyase | |
| 4.3.3.1 | 3-ketovalidoxylamine C-N-lyase | True | 0 | 0 | 0 | 2 | 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one | 4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming] | None | 3-ketovalidoxylamine A C-N-lyase; p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase; 4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase | |
| 4.4.1.1 | cystathionine gamma-lyase | False | 14 | 11390 | 42 | 62 | L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction);;(1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate;;(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);;(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) | L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming) | None | homoserine deaminase; homoserine dehydratase; cystine desulfhydrase; cysteine desulfhydrase; gamma-cystathionase; cystathionase; homoserine deaminase-cystathionase; gamma-CTL; cystalysin; cysteine lyase; L-cystathionine cysteine-lyase (deaminating); CGL | |
| 4.4.1.2 | homocysteine desulfhydrase | False | 13 | 142 | 0 | 5 | L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate (overall reaction);;(1a) L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate;;(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);;(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) | L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming) | None | homocysteine desulfurase; L-homocysteine hydrogen-sulfide-lyase (deaminating) | |
| 4.4.1.3 | dimethylpropiothetin dethiomethylase | False | 17 | 100 | 3 | 26 | S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate | S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming) | None | desulfhydrase; S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase | |
| 4.4.1.4 | alliin lyase | False | 4 | 41 | 3 | 28 | an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate | S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming) | None | alliinase; cysteine sulfoxide lyase; alkylcysteine sulfoxide lyase; S-alkylcysteine sulfoxide lyase; L-cysteine sulfoxide lyase; S-alkyl-L-cysteine sulfoxide lyase; alliin alkyl-sulfenate-lyase | |
| 4.4.1.5 | lactoylglutathione lyase | False | 30 | 16387 | 37 | 70 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming) | None | methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) | |
| 5.6.1.1 | microtubule-severing ATPase | False | 52 | 6064 | 14 | 20 | n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | ATP phosphohydrolase (tubulin-dimerizing) | None | katanin | |
| 4.4.1.9 | L-3-cyanoalanine synthase | False | 9 | 95 | 0 | 45 | L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide | L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming) | None | beta-cyanoalanine synthase; beta-cyanoalanine synthetase; beta-cyano-L-alanine synthase; L-cysteine hydrogen-sulfide-lyase (adding HCN) | |
| 4.4.1.10 | cysteine lyase | True | 0 | 0 | 0 | 10 | L-cysteine + sulfite = L-cysteate + hydrogen sulfide | L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming) | None | cysteine (sulfite) lyase; L-cysteine hydrogen-sulfide-lyase (adding sulfite) | |
| 4.4.1.11 | methionine gamma-lyase | False | 8 | 6350 | 48 | 49 | L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate (overall reaction);;(1a) L-methionine = methanethiol + 2-aminobut-2-enoate;;(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);;(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) | L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming) | None | L-methioninase; methionine lyase; methioninase; methionine dethiomethylase; L-methionine gamma-lyase; L-methionine methanethiol-lyase (deaminating) | |
| 4.4.1.13 | cysteine-S-conjugate beta-lyase | False | 35 | 23704 | 5 | 58 | an L-cysteine-S-conjugate + H2O = a thiol + NH3 + pyruvate (overall reaction);;(1a) an L-cysteine-S-conjugate = a thiol + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous);; | L-cysteine-S-conjugate thiol-lyase (deaminating; 2-aminoprop-2-enoate-forming) | None | cysteine conjugate beta-lyase; glutamine transaminase K/cysteine conjugate beta-lyase; L-cysteine-S-conjugate thiol-lyase (deaminating); cystathionine beta-lyase; beta-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionine L-homocysteine-lyase (deaminating); CBL; S-alkylcysteine lyase; S-alkylcysteinase; alkylcysteine lyase; S-alkyl-L-cysteine lyase; S-alkyl-L-cysteinase; alkyl cysteine lyase; S-alkyl-L-cysteine alkylthiol-lyase (deaminating) | |
| 4.4.1.14 | 1-aminocyclopropane-1-carboxylate synthase | False | 28 | 4652 | 9 | 50 | S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine | S-adenosyl-L-methionine S-methyl-5'-thioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) | None | 1-aminocyclopropanecarboxylate synthase; 1-aminocyclopropane-1-carboxylic acid synthase; 1-aminocyclopropane-1-carboxylate synthetase; aminocyclopropanecarboxylic acid synthase; aminocyclopropanecarboxylate synthase; ACC synthase; S-adenosyl-L-methionine methylthioadenosine-lyase; S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) | |
| 4.4.1.15 | D-cysteine desulfhydrase | False | 49 | 2668 | 13 | 15 | D-cysteine + H2O = sulfide + NH3 + pyruvate | D-cysteine sulfide-lyase (deaminating; pyruvate-forming) | None | D-cysteine lyase; D-cysteine sulfide-lyase (deaminating) | |
| 4.4.1.16 | selenocysteine lyase | False | 67 | 2609 | 9 | 17 | L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor | L-selenocysteine selenide-lyase (L-alanine-forming) | None | selenocysteine reductase; selenocysteine beta-lyase | |
| 4.4.1.17 | holocytochrome-c synthase | False | 13 | 6326 | 0 | 7 | holocytochrome c = apocytochrome c + heme | holocytochrome-c apocytochrome-c-lyase (heme-forming) | None | cytochrome c heme-lyase; holocytochrome c synthetase; holocytochrome-c apocytochrome-c-lyase | |
| 4.4.1.19 | phosphosulfolactate synthase | False | 4 | 410 | 1 | 3 | (2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite | (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming) | None | (2R)-phospho-3-sulfolactate synthase; (2R)-O-phospho-3-sulfolactate sulfo-lyase | |
| 4.4.1.20 | leukotriene-C4 synthase | False | 14 | 955 | 17 | 9 | leukotriene C4 = leukotriene A4 + glutathione | leukotriene-C4 glutathione-lyase (leukotriene-A4-forming) | None | leukotriene C4 synthetase; LTC4 synthase; LTC4 synthetase; leukotriene A4:glutathione S-leukotrienyltransferase; (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening); (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming) | |
| 4.4.1.21 | S-ribosylhomocysteine lyase | False | 288 | 9043 | 6 | 64 | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming] | None | S-ribosylhomocysteinase; LuxS | |
| 4.4.1.22 | S-(hydroxymethyl)glutathione synthase | False | 30 | 2254 | 0 | 1 | S-(hydroxymethyl)glutathione = glutathione + formaldehyde | S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming) | None | glutathione-dependent formaldehyde-activating enzyme; Gfa; S-(hydroxymethyl)glutathione formaldehyde-lyase | |
| 4.4.1.23 | 2-hydroxypropyl-CoM lyase | False | 1 | 279 | 0 | 6 | (1) (R)-2-hydroxypropyl-CoM = (R)-1,2-epoxypropane + HS-CoM;; (2) (S)-2-hydroxypropyl-CoM = (S)-1,2-epoxypropane + HS-CoM | (R)[or (S)]-2-hydroxypropyl-CoM:2-sulfanylethane-1-sulfonate lyase (epoxyalkane-ring-forming) | None | epoxyalkane:coenzyme M transferase; epoxyalkane:CoM transferase; epoxyalkane:2-mercaptoethanesulfonate transferase; coenzyme M-epoxyalkane ligase; epoxyalkyl:CoM transferase; epoxypropane:coenzyme M transferase; epoxypropyl:CoM transferase; EaCoMT; 2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming); (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; (R)-1,2-epoxypropane-forming) | |
| 4.5.1.1 | DDT-dehydrochlorinase | False | 8 | 1 | 0 | 9 | 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride | 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming] | None | DDT-ase; 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase; DDTase | |
| 4.5.1.2 | 3-chloro-D-alanine dehydrochlorinase | True | 0 | 0 | 0 | 2 | 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3 (overall reaction);;(1a) 3-chloro-D-alanine = chloride + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | 3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming) | None | beta-chloro-D-alanine dehydrochlorinase; 3-chloro-D-alanine chloride-lyase (deaminating) | |
| 4.5.1.3 | dichloromethane dehalogenase | False | 2 | 100 | 0 | 11 | dichloromethane + H2O = formaldehyde + 2 chloride | dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming) | None | dichloromethane chloride-lyase (chloride-hydrolysing) | |
| 4.5.1.4 | L-2-amino-4-chloropent-4-enoate dehydrochlorinase | True | 0 | 0 | 0 | 1 | L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + NH3 | L-2-amino-4-chloropent-4-enoate chloride-lyase (adding water; deaminating; 2-oxopent-4-enoate-forming) | None | L-2-amino-4-chloro-4-pentenoate dehalogenase; L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating); L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming) | |
| 4.5.1.5 | S-carboxymethylcysteine synthase | False | 1 | 1 | 0 | 1 | 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride | 3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming) | None | S-carboxymethyl-L-cysteine synthase | |
| 4.6.1.1 | adenylate cyclase | False | 95 | 29542 | 127 | 106 | ATP = 3',5'-cyclic AMP + diphosphate | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) | None | adenylylcyclase; adenyl cyclase; 3',5'-cyclic AMP synthetase; ATP diphosphate-lyase (cyclizing) | |
| 4.6.1.2 | guanylate cyclase | False | 93 | 19805 | 35 | 54 | GTP = 3',5'-cyclic GMP + diphosphate | GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) | None | guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing) | |
| 4.6.1.6 | cytidylate cyclase | False | 3 | 1 | 2 | 4 | CTP = 3',5'-cyclic CMP + diphosphate | CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) | None | 3',5'-cyclic-CMP synthase; cytidylyl cyclase; cytidyl cyclase; CTP diphosphate-lyase (cyclizing); pycC (gene name) (ambiguous) | |
| 4.6.1.12 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | False | 527 | 34624 | 65 | 19 | 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP | 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming) | None | MECDP-synthase; 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing) | |
| 4.6.1.13 | phosphatidylinositol diacylglycerol-lyase | False | 5 | 2603 | 19 | 11 | 1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming) | None | monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) | |
| 4.6.1.14 | glycosylphosphatidylinositol diacylglycerol-lyase | False | 2 | 16 | 0 | 8 | 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming] | None | (glycosyl)phosphatidylinositol-specific phospholipase C; GPI-PLC; GPI-specific phospholipase C; VSG-lipase; glycosyl inositol phospholipid anchor-hydrolyzing enzyme; glycosylphosphatidylinositol-phospholipase C; glycosylphosphatidylinositol-specific phospholipase C; variant-surface-glycoprotein phospholipase C; 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) | |
| 4.6.1.15 | FAD-AMP lyase (cyclizing) | False | 5 | 1464 | 0 | 2 | FAD = AMP + riboflavin cyclic-4',5'-phosphate | FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) | None | FMN cyclase; FAD AMP-lyase (cyclic-FMN-forming) | |
| 4.99.1.2 | alkylmercury lyase | False | 10 | 665 | 17 | 13 | an alkylmercury + H+ = an alkane + Hg2+ | alkylmercury mercury(II)-lyase (alkane-forming) | None | organomercury lyase; organomercurial lyase; alkylmercury mercuric-lyase | |
| 4.99.1.3 | sirohydrochlorin cobaltochelatase | False | 25 | 2835 | 23 | 15 | cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+ | cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming) | None | CbiK; CbiX; CbiXS; anaerobic cobalt chelatase; cobaltochelatase [ambiguous]; sirohydrochlorin cobalt-lyase | |
| 4.99.1.4 | sirohydrochlorin ferrochelatase | False | 149 | 6201 | 4 | 5 | siroheme + 2 H+ = sirohydrochlorin + Fe2+ | siroheme ferro-lyase (sirohydrochlorin-forming) | None | CysG; Met8P; SirB; sirohydrochlorin ferro-lyase (incorrect) | |
| 5.1.1.1 | alanine racemase | False | 371 | 46742 | 61 | 65 | L-alanine = D-alanine | alanine racemase | None | L-alanine racemase | |
| 5.1.1.2 | methionine racemase | False | 2 | 0 | 0 | 1 | L-methionine = D-methionine | methionine racemase | None | None | |
| 5.1.1.3 | glutamate racemase | False | 345 | 32580 | 35 | 31 | L-glutamate = D-glutamate | glutamate racemase | None | None | |
| 5.1.1.4 | proline racemase | False | 5 | 618 | 8 | 15 | L-proline = D-proline | proline racemase | None | None | |
| 5.1.1.5 | lysine racemase | False | 3 | 7 | 1 | 5 | L-lysine = D-lysine | lysine racemase | None | None | |
| 5.1.1.6 | threonine racemase | True | 0 | 0 | 0 | 2 | L-threonine = D-threonine | threonine racemase | None | None | |
| 5.1.1.7 | diaminopimelate epimerase | False | 423 | 38863 | 22 | 23 | LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate | LL-2,6-diaminoheptanedioate 2-epimerase | None | None | |
| 5.1.1.8 | 4-hydroxyproline epimerase | False | 49 | 2492 | 0 | 11 | trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline | 4-hydroxyproline 2-epimerase | None | hydroxyproline epimerase; hydroxyproline 2-epimerase; L-hydroxyproline epimerase | |
| 5.1.1.9 | arginine racemase | False | 0 | 1 | 0 | 3 | L-arginine = D-arginine | arginine racemase | None | None | |
| 5.1.1.10 | amino-acid racemase | False | 11 | 608 | 8 | 22 | an L-amino acid = a D-amino acid | amino-acid racemase | None | L-amino acid racemase | |
| 5.1.1.11 | phenylalanine racemase (ATP-hydrolysing) | False | 5 | 507 | 9 | 1 | ATP + L-phenylalanine + H2O = AMP + diphosphate + D-phenylalanine | phenylalanine racemase (ATP-hydrolysing) | None | phenylalanine racemase; phenylalanine racemase (adenosine triphosphate-hydrolysing); gramicidin S synthetase I | |
| 5.1.1.12 | ornithine racemase | False | 3 | 165 | 0 | 2 | L-ornithine = D-ornithine | ornithine racemase | None | None | |
| 5.1.1.13 | aspartate racemase | False | 8 | 1771 | 7 | 28 | L-aspartate = D-aspartate | aspartate racemase | None | D-aspartate racemase; McyF | |
| 5.1.1.14 | nocardicin A epimerase | False | 1 | 0 | 0 | 1 | (1) isonocardicin C = nocardicin C;;(2) isonocardicin A = nocardicin A | nocardicin-C epimerase | None | isonocardicin A epimerase; nocJ (gene name) | |
| 5.1.1.15 | 2-aminohexano-6-lactam racemase | False | 1 | 7 | 3 | 11 | (S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam | 2-aminohexano-6-lactam racemase | None | alpha-amino-epsilon-caprolactam racemase | |
| 5.1.1.16 | protein-serine epimerase | False | 0 | 2 | 1 | 2 | [protein]-L-serine = [protein]-D-serine | [protein]-serine epimerase | None | protein-serine racemase | |
| 5.1.1.17 | isopenicillin-N epimerase | False | 4 | 414 | 0 | 5 | isopenicillin N = penicillin N | penicillin-N 5-amino-5-carboxypentanoyl-epimerase | None | None | |
| 5.1.2.1 | lactate racemase | False | 2 | 87 | 5 | 10 | (S)-lactate = (R)-lactate | lactate racemase | None | lacticoracemase; hydroxyacid racemase; lactic acid racemase; larA (gene name) | |
| 5.1.2.2 | mandelate racemase | False | 1 | 419 | 18 | 2 | (S)-mandelate = (R)-mandelate | mandelate racemase | None | None | |
| 5.1.2.3 | 3-hydroxybutyryl-CoA epimerase | False | 202 | 5567 | 0 | 8 | (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA | 3-hydroxybutanoyl-CoA 3-epimerase | None | 3-hydroxybutyryl coenzyme A epimerase; 3-hydroxyacyl-CoA epimerase | |
| 5.1.2.4 | acetoin racemase | True | 0 | 0 | 0 | 2 | (S)-acetoin = (R)-acetoin | acetoin racemase | None | acetylmethylcarbinol racemase | |
| 5.1.2.5 | tartrate epimerase | True | 0 | 0 | 0 | 1 | (R,R)-tartrate = meso-tartrate | tartrate epimerase | None | tartaric racemase | |
| 5.1.2.6 | isocitrate epimerase | True | 0 | 0 | 0 | 1 | (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate | (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase | None | None | |
| 5.1.3.1 | ribulose-phosphate 3-epimerase | False | 44 | 45422 | 15 | 18 | D-ribulose 5-phosphate = D-xylulose 5-phosphate | D-ribulose-5-phosphate 3-epimerase | None | phosphoribulose epimerase; erythrose-4-phosphate isomerase; phosphoketopentose 3-epimerase; xylulose phosphate 3-epimerase; phosphoketopentose epimerase; ribulose 5-phosphate 3-epimerase; D-ribulose phosphate-3-epimerase; D-ribulose 5-phosphate epimerase; D-ribulose-5-P 3-epimerase; D-xylulose-5-phosphate 3-epimerase; pentose-5-phosphate 3-epimerase | |
| 5.1.3.2 | UDP-glucose 4-epimerase | False | 71 | 59501 | 50 | 55 | UDP-alpha-D-glucose = UDP-alpha-D-galactose | UDP-alpha-D-glucose 4-epimerase | None | UDP-galactose 4-epimerase; uridine diphosphoglucose epimerase; galactowaldenase; UDPG-4-epimerase; uridine diphosphate galactose 4-epimerase; uridine diphospho-galactose-4-epimerase; UDP-glucose epimerase; 4-epimerase; uridine diphosphoglucose 4-epimerase; uridine diphosphate glucose 4-epimerase; UDP-D-galactose 4-epimerase | |
| 5.1.3.3 | aldose 1-epimerase | False | 19 | 23700 | 29 | 31 | alpha-D-glucose = beta-D-glucose | aldose 1-epimerase | None | mutarotase; aldose mutarotase; galactose mutarotase; galactose 1-epimerase; D-galactose 1-epimerase | |
| 5.1.3.4 | L-ribulose-5-phosphate 4-epimerase | False | 42 | 12240 | 2 | 6 | L-ribulose 5-phosphate = D-xylulose 5-phosphate | L-ribulose-5-phosphate 4-epimerase | None | phosphoribulose isomerase; ribulose phosphate 4-epimerase; L-ribulose-phosphate 4-epimerase; L-ribulose 5-phosphate 4-epimerase; AraD; L-Ru5P | |
| 5.1.3.5 | UDP-arabinose 4-epimerase | False | 10 | 21 | 0 | 12 | UDP-L-arabinose = UDP-D-xylose | UDP-L-arabinose 4-epimerase | None | uridine diphosphoarabinose epimerase; UDP arabinose epimerase; uridine 5'-diphosphate-D-xylose 4-epimerase; UDP-D-xylose 4-epimerase | |
| 5.1.3.6 | UDP-glucuronate 4-epimerase | False | 9 | 581 | 0 | 13 | UDP-glucuronate = UDP-D-galacturonate | UDP-glucuronate 4-epimerase | None | uridine diphospho-D-galacturonic acid; UDP glucuronic epimerase; uridine diphosphoglucuronic epimerase; UDP-galacturonate 4-epimerase; uridine diphosphoglucuronate epimerase; UDP-D-galacturonic acid 4-epimerase | |
| 5.1.3.7 | UDP-N-acetylglucosamine 4-epimerase | False | 9 | 740 | 4 | 22 | UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine | UDP-N-acetyl-alpha-D-glucosamine 4-epimerase | None | UDP acetylglucosamine epimerase; uridine diphosphoacetylglucosamine epimerase; uridine diphosphate N-acetylglucosamine-4-epimerase; uridine 5'-diphospho-N-acetylglucosamine-4-epimerase; UDP-N-acetyl-D-glucosamine 4-epimerase | |
| 5.1.3.8 | N-acylglucosamine 2-epimerase | False | 6 | 1160 | 1 | 12 | N-acyl-D-glucosamine = N-acyl-D-mannosamine | N-acyl-D-glucosamine 2-epimerase | None | acylglucosamine 2-epimerase; N-acetylglucosamine 2-epimerase | |
| 5.1.3.9 | N-acylglucosamine-6-phosphate 2-epimerase | False | 144 | 7398 | 15 | 4 | N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate | N-acyl-D-glucosamine-6-phosphate 2-epimerase | None | acylglucosamine-6-phosphate 2-epimerase; acylglucosamine phosphate 2-epimerase | |
| 5.1.3.10 | CDP-paratose 2-epimerase | False | 1 | 366 | 0 | 3 | CDP-alpha-D-paratose = CDP-alpha-D-tyvelose | CDP-3,6-dideoxy-D-glucose 2-epimerase | None | CDP-paratose epimerase; cytidine diphosphoabequose epimerase; cytidine diphosphodideoxyglucose epimerase; cytidine diphosphoparatose epimerase; cytidine diphosphate paratose-2-epimerase; CDP-abequose epimerase (incorrect); CDP-D-abequose 2-epimerase (incorrect); CDP-tyvelose 2-epimerase, | |
| 5.1.3.11 | cellobiose epimerase | False | 6 | 2232 | 11 | 21 | cellobiose = 4-O-beta-D-glucopyranosyl-D-mannose | cellobiose 2-epimerase | None | None | |
| 5.1.3.13 | dTDP-4-dehydrorhamnose 3,5-epimerase | False | 12 | 29517 | 30 | 15 | dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose | dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3,5-epimerase | None | dTDP-L-rhamnose synthetase; dTDP-L-rhamnose synthase; thymidine diphospho-4-ketorhamnose 3,5-epimerase; TDP-4-ketorhamnose 3,5-epimerase; dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase; TDP-4-keto-L-rhamnose-3,5-epimerase | |
| 5.1.3.14 | UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) | False | 14 | 24307 | 18 | 17 | UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine | UDP-N-acetyl-alpha-D-glucosamine 2-epimerase | None | UDP-N-acetylglucosamine 2'-epimerase (ambiguous); uridine diphosphoacetylglucosamine 2'-epimerase (ambiguous); uridine diphospho-N-acetylglucosamine 2'-epimerase (ambiguous); uridine diphosphate-N-acetylglucosamine-2'-epimerase (ambiguous); rffE (gene name); mnaA (gene name); UDP-N-acetyl-D-glucosamine 2-epimerase | |
| 5.1.3.15 | glucose-6-phosphate 1-epimerase | False | 5 | 12124 | 3 | 4 | alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate | D-glucose-6-phosphate 1-epimerase | None | None | |
| 5.1.3.16 | UDP-glucosamine 4-epimerase | True | 0 | 0 | 0 | 2 | UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine | UDP-alpha-D-glucosamine 4-epimerase | None | None | |
| 5.1.3.17 | heparosan-N-sulfate-glucuronate 5-epimerase | False | 5 | 1714 | 5 | 36 | Epimerization of D-glucuronate in heparosan-N-sulfate to L-iduronate. | poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase | None | heparosan epimerase; heparosan-N-sulfate-D-glucuronosyl 5-epimerase; C-5 uronosyl epimerase; polyglucuronate epimerase; D-glucuronyl C-5 epimerase; poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase | |
| 5.1.3.18 | GDP-mannose 3,5-epimerase | False | 4 | 63 | 6 | 11 | (1) GDP-alpha-D-mannose = GDP-beta-L-galactose;;(2) GDP-alpha-D-mannose = GDP-beta-L-gulose | GDP-alpha-D-mannose 3,5-epimerase | None | GME (gene name); GDP-D-mannose:GDP-L-galactose epimerase; guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase | |
| 5.1.3.19 | chondroitin-glucuronate 5-epimerase | False | 3 | 5 | 1 | 5 | chondroitin D-glucuronate = dermatan L-iduronate | chondroitin-D-glucuronate 5-epimerase | None | polyglucuronate 5-epimerase; dermatan-sulfate 5-epimerase; urunosyl C-5 epimerase; chondroitin D-glucuronosyl 5-epimerase | |
| 5.1.3.20 | ADP-glyceromanno-heptose 6-epimerase | False | 158 | 8741 | 5 | 7 | ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose | ADP-L-glycero-D-manno-heptose 6-epimerase | None | None | |
| 5.1.3.21 | maltose epimerase | False | 1 | 325 | 0 | 1 | alpha-maltose = beta-maltose | maltose 1-epimerase | None | None | |
| 5.1.3.22 | L-ribulose-5-phosphate 3-epimerase | False | 43 | 918 | 4 | 2 | L-ribulose 5-phosphate = L-xylulose 5-phosphate | L-ribulose-5-phosphate 3-epimerase | None | L-xylulose 5-phosphate 3-epimerase; UlaE; SgaU | |
| 5.1.99.1 | methylmalonyl-CoA epimerase | False | 6 | 8886 | 6 | 12 | (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA | methylmalonyl-CoA 2-epimerase | None | methylmalonyl-CoA racemase; methylmalonyl coenzyme A racemase; DL-methylmalonyl-CoA racemase; 2-methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect] | |
| 5.1.99.2 | 16-hydroxysteroid epimerase | True | 0 | 0 | 0 | 3 | 16alpha-hydroxysteroid = 16beta-hydroxysteroid | 16-hydroxysteroid 16-epimerase | None | None | |
| 5.1.99.3 | allantoin racemase | False | 0 | 334 | 2 | 7 | (S)(+)-allantoin = (R)(-)-allantoin | allantoin racemase | None | None | |
| 5.1.99.4 | alpha-methylacyl-CoA racemase | False | 4 | 772 | 11 | 5 | (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA | 2-methylacyl-CoA 2-epimerase | None | None | |
| 5.2.1.1 | maleate isomerase | False | 4 | 2453 | 2 | 9 | maleate = fumarate | maleate cis-trans-isomerase | None | None | |
| 5.2.1.2 | maleylacetoacetate isomerase | False | 12 | 6792 | 9 | 13 | 4-maleylacetoacetate = 4-fumarylacetoacetate | 4-maleylacetoacetate cis-trans-isomerase | None | maleylacetoacetic isomerase; maleylacetone isomerase; maleylacetone cis-trans-isomerase | |
| 5.2.1.4 | maleylpyruvate isomerase | False | 2 | 823 | 2 | 22 | 3-maleylpyruvate = 3-fumarylpyruvate | 3-maleylpyruvate cis-trans-isomerase | None | None | |
| 5.2.1.5 | linoleate isomerase | False | 0 | 8 | 0 | 14 | 9-cis,12-cis-octadecadienoate = 9-cis,11-trans-octadecadienoate | linoleate Delta12-cis-Delta11-trans-isomerase | None | linoleic acid isomerase | |
| 5.2.1.6 | furylfuramide isomerase | True | 0 | 0 | 0 | 2 | (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide | 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase | None | None | |
| 5.2.1.8 | peptidylprolyl isomerase | False | 1503 | 328794 | 882 | 61 | peptidylproline (omega=180) = peptidylproline (omega=0) | peptidylproline cis-trans-isomerase | None | PPIase; cyclophilin [misleading, see comments]; peptide bond isomerase; peptidyl-prolyl cis-trans isomerase | |
| 5.2.1.9 | farnesol 2-isomerase | True | 0 | 0 | 0 | 1 | (2E,6E)-farnesol = (2Z,6E)-farnesol | (2E,6E)-farnesol 2-cis-trans-isomerase | None | farnesol isomerase | |
| 5.2.1.10 | 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase | True | 0 | 0 | 0 | 1 | cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide | 2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase | None | 2-chlorocarboxymethylenebutenolide isomerase; chlorodienelactone isomerase | |
| 5.3.1.1 | triose-phosphate isomerase | False | 654 | 58481 | 250 | 63 | D-glyceraldehyde 3-phosphate = glycerone phosphate | D-glyceraldehyde-3-phosphate aldose-ketose-isomerase | None | phosphotriose isomerase; triose phosphoisomerase; triose phosphate mutase; D-glyceraldehyde-3-phosphate ketol-isomerase | |
| 5.3.1.3 | D-arabinose isomerase | False | 1 | 10 | 4 | 5 | D-arabinose = D-ribulose | D-arabinose aldose-ketose-isomerase | None | D-arabinose(L-fucose) isomerase; L-fucose isomerase; D-arabinose ketol-isomerase; arabinose isomerase (misleading) | |
| 5.3.1.4 | L-arabinose isomerase | False | 115 | 7220 | 13 | 41 | beta-L-arabinopyranose = L-ribulose | beta-L-arabinopyranose aldose-ketose-isomerase | None | L-arabinose ketol-isomerase; araA (gene name) | |
| 5.3.1.5 | xylose isomerase | False | 198 | 17192 | 192 | 108 | alpha-D-xylopyranose = alpha-D-xylulofuranose | alpha-D-xylopyranose aldose-ketose-isomerase | None | D-xylose isomerase; D-xylose ketoisomerase; D-xylose ketol-isomerase; D-xylose aldose-ketose-isomerase | |
| 5.3.1.6 | ribose-5-phosphate isomerase | False | 475 | 43693 | 53 | 37 | D-ribose 5-phosphate = D-ribulose 5-phosphate | D-ribose-5-phosphate aldose-ketose-isomerase | None | phosphopentosisomerase; phosphoriboisomerase; ribose phosphate isomerase; 5-phosphoribose isomerase; D-ribose 5-phosphate isomerase; D-ribose-5-phosphate ketol-isomerase | |
| 5.3.1.7 | mannose isomerase | False | 6 | 22 | 0 | 11 | D-mannose = D-fructose | D-mannose aldose-ketose-isomerase | None | D-mannose isomerase; D-mannose ketol-isomerase | |
| 5.3.1.8 | mannose-6-phosphate isomerase | False | 41 | 18751 | 17 | 53 | D-mannose 6-phosphate = D-fructose 6-phosphate | D-mannose-6-phosphate aldose-ketose-isomerase | None | phosphomannose isomerase; phosphohexomutase; phosphohexoisomerase; mannose phosphate isomerase; phosphomannoisomerase; D-mannose-6-phosphate ketol-isomerase | |
| 5.3.1.9 | glucose-6-phosphate isomerase | False | 639 | 50884 | 89 | 63 | alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate | alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting) | None | phosphohexose isomerase; phosphohexomutase; oxoisomerase; hexosephosphate isomerase; phosphosaccharomutase; phosphoglucoisomerase; phosphohexoisomerase; phosphoglucose isomerase; glucose phosphate isomerase; hexose phosphate isomerase; D-glucose-6-phosphate ketol-isomerase | |
| 5.3.1.12 | glucuronate isomerase | False | 132 | 12338 | 3 | 4 | D-glucuronate = D-fructuronate | D-glucuronate aldose-ketose-isomerase | None | uronic isomerase; uronate isomerase; D-glucuronate isomerase; uronic acid isomerase; D-glucuronate ketol-isomerase | |
| 5.3.1.13 | arabinose-5-phosphate isomerase | False | 20 | 9536 | 2 | 9 | D-arabinose 5-phosphate = D-ribulose 5-phosphate | D-arabinose-5-phosphate aldose-ketose-isomerase | None | kdsD (gene name); gutQ (gene name); arabinose phosphate isomerase; phosphoarabinoisomerase; D-arabinose-5-phosphate ketol-isomerase | |
| 5.3.1.14 | L-rhamnose isomerase | False | 72 | 5597 | 27 | 20 | L-rhamnopyranose = L-rhamnulose | L-rhamnose aldose-ketose-isomerase | None | rhamnose isomerase; L-rhamnose ketol-isomerase | |
| 5.3.1.15 | D-lyxose ketol-isomerase | False | 6 | 88 | 4 | 9 | D-lyxose = D-xylulose | D-lyxose aldose-ketose-isomerase | None | D-lyxose isomerase; D-lyxose ketol-isomerase | |
| 5.3.1.16 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase | False | 638 | 35740 | 30 | 7 | 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide | 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase | None | N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase; N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase | |
| 5.3.1.17 | 5-dehydro-4-deoxy-D-glucuronate isomerase | False | 93 | 8020 | 7 | 3 | 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate | 5-dehydro-4-deoxy-D-glucuronate aldose-ketose-isomerase | None | 4-deoxy-L-threo-5-hexulose uronate isomerase; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; kduI (gene name) | |
| 5.3.1.20 | ribose isomerase | True | 0 | 0 | 0 | 2 | D-ribose = D-ribulose | D-ribose aldose-ketose-isomerase | None | D-ribose isomerase; D-ribose ketol-isomerase | |
| 5.3.1.21 | corticosteroid side-chain-isomerase | True | 0 | 0 | 0 | 12 | 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al | 11-deoxycorticosterone aldose-ketose-isomerase | None | None | |
| 5.3.1.22 | hydroxypyruvate isomerase | False | 9 | 4994 | 1 | 3 | hydroxypyruvate = 2-hydroxy-3-oxopropanoate | hydroxypyruvate aldose-ketose-isomerase | None | None | |
| 5.3.1.23 | S-methyl-5-thioribose-1-phosphate isomerase | False | 294 | 21707 | 8 | 6 | S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate | S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase | None | methylthioribose 1-phosphate isomerase; 1-PMTR isomerase; 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase; S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase; S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase; 1-phospho-5'-S-methylthioribose isomerase; S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase | |
| 5.3.1.24 | phosphoribosylanthranilate isomerase | False | 366 | 37822 | 12 | 31 | N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase | None | PRA isomerase; PRAI; IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex); N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase | |
| 5.3.1.25 | L-fucose isomerase | False | 60 | 3749 | 5 | 7 | L-fucopyranose = L-fuculose | L-fucose aldose-ketose-isomerase | None | None | |
| 5.3.1.26 | galactose-6-phosphate isomerase | False | 112 | 1629 | 4 | 3 | D-galactose 6-phosphate = D-tagatose 6-phosphate | D-galactose-6-phosphate aldose-ketose-isomerase | None | None | |
| 5.3.2.1 | phenylpyruvate tautomerase | False | 16 | 5101 | 107 | 14 | keto-phenylpyruvate = enol-phenylpyruvate | phenylpyruvate keto---enol-isomerase | None | phenylpyruvic keto-enol isomerase | |
| 5.3.2.2 | oxaloacetate tautomerase | False | 25 | 4 | 4 | 3 | keto-oxaloacetate = enol-oxaloacetate | oxaloacetate keto---enol-isomerase | None | oxalacetic keto-enol isomerase | |
| 5.3.3.1 | steroid Delta-isomerase | False | 32 | 355 | 84 | 15 | a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid | 3-oxosteroid Delta5-Delta4-isomerase | None | hydroxysteroid isomerase; steroid isomerase; Delta5-ketosteroid isomerase; Delta5(or Delta4)-3-keto steroid isomerase; Delta5-steroid isomerase; 3-oxosteroid isomerase; Delta5-3-keto steroid isomerase; Delta5-3-oxosteroid isomerase | |
| 5.3.3.2 | isopentenyl-diphosphate Delta-isomerase | False | 279 | 23516 | 40 | 48 | 3-methylbut-3-en-1-yl diphosphate = prenyl diphosphate | 3-methylbut-3-en-1-yl-diphosphate Delta3-Delta2-isomerase | None | isopentenylpyrophosphate Delta-isomerase; methylbutenylpyrophosphate isomerase; isopentenylpyrophosphate isomerase; isopentenyl-diphosphate Delta3-Delta2-isomerase | |
| 5.3.3.3 | vinylacetyl-CoA Delta-isomerase | False | 1 | 193 | 1 | 10 | vinylacetyl-CoA = (E)-but-2-enoyl-CoA | vinylacetyl-CoA Delta3-Delta2-isomerase | None | vinylacetyl coenzyme A Delta-isomerase; vinylacetyl coenzyme A isomerase; Delta3-cis-Delta2-trans-enoyl-CoA isomerase | |
| 5.3.3.4 | muconolactone Delta-isomerase | False | 7 | 3576 | 2 | 6 | (+)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate | (+)-muconolactone Delta3-Delta2-isomerase | None | muconolactone isomerase; 5-oxo-4,5-dihydrofuran-2-acetate Delta3-Delta2-isomerase | |
| 5.3.3.5 | cholestenol Delta-isomerase | False | 7 | 2918 | 3 | 8 | 5alpha-cholest-7-en-3beta-ol = 5alpha-cholest-8-en-3beta-ol | Delta7-cholestenol Delta7-Delta8-isomerase | None | None | |
| 5.3.3.6 | methylitaconate Delta-isomerase | False | 1 | 432 | 0 | 1 | methylitaconate = 2,3-dimethylmaleate | methylitaconate Delta2-Delta3-isomerase | None | methylitaconate isomerase | |
| 5.3.3.7 | aconitate Delta-isomerase | False | 1 | 92 | 0 | 30 | trans-aconitate = cis-aconitate | aconitate Delta2-Delta3-isomerase | None | aconitate isomerase | |
| 5.3.3.8 | Delta3-Delta2-enoyl-CoA isomerase | False | 149 | 5793 | 17 | 12 | (1) a (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA;;(2) a (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA | (3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase | None | ECI (gene name); dodecenoyl-CoA isomerase; dodecenoyl-CoA Delta-isomerase; Delta3-cis-Delta2-trans-enoyl-CoA isomerase; acetylene-allene isomerase; dodecenoyl-CoA Delta3-cis-Delta2-trans-isomerase; dodecenoyl-CoA (3Z)-(2E)-isomerase | |
| 5.3.3.9 | prostaglandin-A1 Delta-isomerase | True | 0 | 0 | 0 | 11 | (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate | (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate Delta10-Delta11-isomerase | None | prostaglandin A isomerase | |
| 5.3.3.10 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | False | 4 | 1778 | 6 | 2 | 5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate | 5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase | None | CHM isomerase; 5-carboxymethyl-2-hydroxymuconic acid isomerase | |
| 5.3.3.11 | isopiperitenone Delta-isomerase | True | 0 | 0 | 0 | 1 | isopiperitenone = piperitenone | isopiperitenone Delta8-Delta4-isomerase | None | None | |
| 5.3.3.12 | L-dopachrome isomerase | False | 24 | 6089 | 0 | 8 | L-dopachrome = 5,6-dihydroxyindole-2-carboxylate | L-dopachrome keto-enol isomerase | None | dopachrome tautomerase; tyrosinase-related protein 2; TRP-1; TRP2; TRP-2; tyrosinase-related protein-2; dopachrome Delta7,Delta2-isomerase; dopachrome Delta-isomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome-rearranging enzyme; DCF; DCT; dopachrome keto-enol isomerase; L-dopachrome-methyl ester tautomerase | |
| 5.3.3.13 | polyenoic fatty acid isomerase | False | 1 | 1 | 0 | 2 | (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate | (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming) | None | PFI; eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase; (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase (incorrect); (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming) | |
| 5.3.4.1 | protein disulfide-isomerase | False | 106 | 17392 | 61 | 79 | Catalyses the rearrangement of -S-S- bonds in proteins | protein disulfide-isomerase | None | S-S rearrangase | |
| 5.3.99.2 | prostaglandin-D synthase | False | 17 | 653 | 54 | 13 | (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate | (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase | None | prostaglandin-H2 Delta-isomerase; prostaglandin-R-prostaglandin D isomerase; PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect); (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase; prostaglandin endoperoxide Delta-isomerase; prostaglandin D synthetase | |
| 5.3.99.3 | prostaglandin-E synthase | False | 20 | 3946 | 24 | 16 | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase | None | prostaglandin-H2 E-isomerase; endoperoxide isomerase; endoperoxide isomerase; prostaglandin R-prostaglandin E isomerase; prostaglandin endoperoxide E isomerase; PGE isomerase; PGH-PGE isomerase; PGE2 isomerase; prostaglandin endoperoxide E2 isomerase; prostaglandin H-E isomerase | |
| 5.3.99.4 | prostaglandin-I synthase | False | 5 | 815 | 4 | 8 | (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate | (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase | None | prostacyclin synthase; prostacycline synthetase; prostagladin I2 synthetase; PGI2 synthase; PGI2 synthetase; (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase | |
| 5.3.99.5 | thromboxane-A synthase | False | 8 | 804 | 0 | 9 | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase | None | thromboxane synthase; (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase | |
| 5.3.99.6 | allene-oxide cyclase | False | 7 | 999 | 12 | 28 | (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate | (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing) | None | None | |
| 5.3.99.7 | styrene-oxide isomerase | False | 1 | 16 | 0 | 9 | styrene oxide = phenylacetaldehyde | styrene-oxide isomerase (epoxide-cleaving) | None | SOI | |
| 5.3.99.8 | capsanthin/capsorubin synthase | False | 2 | 16 | 0 | 3 | (1) violaxanthin = capsorubin;;(2) antheraxanthin = capsanthin | violaxanthin---capsorubin isomerase (ketone-forming) | None | CCS; ketoxanthophyll synthase; capsanthin-capsorubin synthase | |
| 5.3.99.9 | neoxanthin synthase | False | 2 | 11 | 0 | 4 | violaxanthin = neoxanthin | violaxanthin---neoxanthin isomerase (epoxide-opening) | None | NSY | |
| 5.4.1.1 | lysolecithin acylmutase | True | 0 | 0 | 0 | 2 | 2-lysolecithin = 3-lysolecithin | lysolecithin 2,3-acylmutase | None | lysolecithin migratase | |
| 5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) | False | 444 | 29669 | 22 | 19 | 2-phospho-D-glycerate = 3-phospho-D-glycerate (overall reaction);;(1a) [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 2/3-phospho-D-glycerate;;(1b) [enzyme]-Ntau-phospho-L-histidine + 2-phospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate;;(1c) [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 3-phospho-D-glycerate;;(1d) [enzyme]-Ntau-phospho-L-histidine + 2/3-bisphospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate | D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-dependent) | None | glycerate phosphomutase (diphosphoglycerate cofactor); 2,3-diphosphoglycerate dependent phosphoglycerate mutase; cofactor dependent phosphoglycerate mutase; phosphoglycerate phosphomutase (ambiguous); phosphoglyceromutase (ambiguous); monophosphoglycerate mutase (ambiguous); monophosphoglyceromutase (ambiguous); GriP mutase (ambiguous); PGA mutase (ambiguous); MPGM; PGAM; PGAM-d; PGM; dPGM | |
| 5.4.2.2 | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) | False | 63 | 26255 | 35 | 46 | alpha-D-glucose 1-phosphate = D-glucose 6-phosphate | alpha-D-glucose 1,6-phosphomutase | None | glucose phosphomutase (ambiguous); phosphoglucose mutase (ambiguous) | |
| 5.4.2.3 | phosphoacetylglucosamine mutase | False | 10 | 3833 | 7 | 13 | N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate | N-acetyl-alpha-D-glucosamine 1,6-phosphomutase | None | acetylglucosamine phosphomutase; acetylglucosamine phosphomutase; acetylaminodeoxyglucose phosphomutase; phospho-N-acetylglucosamine mutase; N-acetyl-D-glucosamine 1,6-phosphomutase | |
| 5.4.2.4 | bisphosphoglycerate mutase | False | 18 | 2126 | 12 | 5 | 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate | 3-phospho-D-glycerate 1,2-phosphomutase | None | diphosphoglycerate mutase; glycerate phosphomutase; bisphosphoglycerate synthase; bisphosphoglyceromutase; biphosphoglycerate synthase; diphosphoglyceric mutase; 2,3-diphosphoglycerate mutase; phosphoglyceromutase; 2,3-diphosphoglycerate synthase; DPGM; 2,3-bisphosphoglycerate mutase; BPGM; diphosphoglyceromutase; 2,3-diphosphoglyceromutase | |
| 5.4.2.5 | phosphoglucomutase (glucose-cofactor) | True | 0 | 0 | 0 | 3 | alpha-D-glucose 1-phosphate = D-glucose 6-phosphate | alpha-D-glucose 1,6-phosphomutase (glucose-cofactor) | None | glucose phosphomutase (ambiguous); glucose-1-phosphate phosphotransferase | |
| 5.4.2.6 | beta-phosphoglucomutase | False | 7 | 3386 | 56 | 11 | beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate | beta-D-glucose 1,6-phosphomutase | None | beta-pgm (gene name) | |
| 5.4.2.7 | phosphopentomutase | False | 282 | 13501 | 22 | 10 | alpha-D-ribose 1-phosphate = D-ribose 5-phosphate | alpha-D-ribose 1,5-phosphomutase | None | phosphodeoxyribomutase; deoxyribose phosphomutase; deoxyribomutase; phosphoribomutase; alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase; D-ribose 1,5-phosphomutase | |
| 5.4.2.8 | phosphomannomutase | False | 50 | 22587 | 36 | 37 | alpha-D-mannose 1-phosphate = D-mannose 6-phosphate | alpha-D-mannose 1,6-phosphomutase | None | mannose phosphomutase; phosphomannose mutase; D-mannose 1,6-phosphomutase | |
| 5.4.2.9 | phosphoenolpyruvate mutase | False | 6 | 2352 | 6 | 7 | phosphoenolpyruvate = 3-phosphonopyruvate | phosphoenolpyruvate 2,3-phosphonomutase | None | phosphoenolpyruvate-phosphonopyruvate phosphomutase; PEP phosphomutase; phosphoenolpyruvate phosphomutase; PEPPM; PEP phosphomutase | |
| 5.4.2.10 | phosphoglucosamine mutase | False | 687 | 35490 | 7 | 12 | alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate | alpha-D-glucosamine 1,6-phosphomutase | None | None | |
| 5.4.3.2 | lysine 2,3-aminomutase | False | 6 | 4580 | 1 | 12 | L-lysine = (3S)-3,6-diaminohexanoate | L-lysine 2,3-aminomutase | None | None | |
| 5.4.3.3 | lysine 5,6-aminomutase | False | 4 | 234 | 1 | 4 | (1) (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate;;(2) D-lysine = (2R,5S)-2,5-diaminohexanoate | (3S)-3,6-diaminohexanoate 5,6-aminomutase | None | beta-lysine 5,6-aminomutase; beta-lysine mutase; L-beta-lysine 5,6-aminomutase; D-lysine 5,6-aminomutase; D-alpha-lysine mutase; adenosylcobalamin-dependent D-lysine 5,6-aminomutase | |
| 5.4.3.5 | D-ornithine 4,5-aminomutase | False | 2 | 134 | 0 | 10 | D-ornithine = (2R,4S)-2,4-diaminopentanoate | D-ornithine 4,5-aminomutase | None | D-alpha-ornithine 5,4-aminomutase; D-ornithine aminomutase | |
| 5.4.3.6 | tyrosine 2,3-aminomutase | False | 5 | 138 | 4 | 7 | L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate | L-tyrosine 2,3-aminomutase | None | tyrosine alpha,beta-mutase | |
| 5.4.3.7 | leucine 2,3-aminomutase | True | 0 | 0 | 0 | 15 | (2S)-alpha-leucine = (3R)-beta-leucine | (2S)-alpha-leucine 2,3-aminomutase | None | None | |
| 5.4.3.8 | glutamate-1-semialdehyde 2,1-aminomutase | False | 674 | 31395 | 25 | 14 | L-glutamate 1-semialdehyde = 5-aminolevulinate | (S)-4-amino-5-oxopentanoate 4,5-aminomutase | None | glutamate-1-semialdehyde aminotransferase | |
| 5.4.4.1 | (hydroxyamino)benzene mutase | False | 2 | 14 | 0 | 3 | (hydroxyamino)benzene = 2-aminophenol | (hydroxyamino)benzene hydroxymutase | None | HAB mutase; hydroxylaminobenzene hydroxymutase; hydroxylaminobenzene mutase | |
| 5.4.4.2 | isochorismate synthase | False | 19 | 16116 | 12 | 22 | chorismate = isochorismate | isochorismate hydroxymutase | None | MenF | |
| 5.4.4.3 | 3-(hydroxyamino)phenol mutase | False | 1 | 22 | 0 | 1 | 3-hydroxyaminophenol = aminohydroquinone | 3-(hydroxyamino)phenol hydroxymutase | None | 3-hydroxylaminophenol mutase; 3HAP mutase | |
| 5.4.99.1 | methylaspartate mutase | False | 23 | 2505 | 10 | 12 | L-threo-3-methylaspartate = L-glutamate | L-threo-3-methylaspartate carboxy-aminomethylmutase | None | glutamate mutase; glutamic mutase; glutamic isomerase; glutamic acid mutase; glutamic acid isomerase; methylaspartic acid mutase; beta-methylaspartate-glutamate mutase; glutamate isomerase | |
| 5.4.99.2 | methylmalonyl-CoA mutase | False | 22 | 27668 | 23 | 31 | (R)-methylmalonyl-CoA = succinyl-CoA | (R)-methylmalonyl-CoA CoA-carbonylmutase | None | methylmalonyl-CoA CoA-carbonyl mutase; methylmalonyl coenzyme A mutase; methylmalonyl coenzyme A carbonylmutase; (S)-methylmalonyl-CoA mutase; (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase [incorrect] | |
| 5.4.99.3 | 2-acetolactate mutase | True | 0 | 0 | 0 | 1 | 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate | 2-acetolactate methylmutase | None | acetolactate mutase; acetohydroxy acid isomerase | |
| 5.4.99.4 | 2-methyleneglutarate mutase | False | 1 | 18 | 0 | 1 | 2-methyleneglutarate = 2-methylene-3-methylsuccinate | 2-methyleneglutarate carboxy-methylenemethylmutase | None | alpha-methyleneglutarate mutase | |
| 5.4.99.5 | chorismate mutase | False | 50 | 33617 | 52 | 57 | chorismate = prephenate | chorismate pyruvatemutase | None | hydroxyphenylpyruvate synthase | |
| 5.4.99.7 | lanosterol synthase | False | 13 | 163 | 2 | 20 | (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming) | None | 2,3-epoxysqualene lanosterol cyclase; squalene-2,3-oxide-lanosterol cyclase; lanosterol 2,3-oxidosqualene cyclase; squalene 2,3-epoxide:lanosterol cyclase; 2,3-oxidosqualene sterol cyclase; oxidosqualene cyclase; 2,3-oxidosqualene cyclase; 2,3-oxidosqualene-lanosterol cyclase; oxidosqualene-lanosterol cyclase; squalene epoxidase-cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming) | |
| 5.4.99.8 | cycloartenol synthase | False | 12 | 145 | 0 | 25 | (3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, cycloartenol-forming) | None | 2,3-epoxysqualene cycloartenol-cyclase; squalene-2,3-epoxide-cycloartenol cyclase; 2,3-epoxysqualene-cycloartenol cyclase; 2,3-oxidosqualene-cycloartenol cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming) | |
| 5.4.99.9 | UDP-galactopyranose mutase | False | 8 | 6400 | 51 | 16 | UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose | UDP-alpha-D-galactopyranose furanomutase | None | UGM; UDP-D-galactopyranose furanomutase | |
| 5.4.99.11 | isomaltulose synthase | False | 0 | 12 | 14 | 13 | sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose | sucrose glucosylmutase | None | isomaltulose synthetase; sucrose alpha-glucosyltransferase; trehalulose synthase | |
| 5.4.99.12 | tRNA pseudouridine38-40 synthase | False | 630 | 50070 | 9 | 7 | tRNA uridine38-40 = tRNA pseudouridine38-40 | tRNA-uridine38-40 uracil mutase | None | TruA; tRNA pseudouridine synthase I; PSUI; hisT (gene name) | |
| 5.4.99.13 | isobutyryl-CoA mutase | False | 4 | 5536 | 4 | 7 | 2-methylpropanoyl-CoA = butanoyl-CoA | 2-methylpropanoyl-CoA CoA-carbonylmutase | None | isobutyryl coenzyme A mutase; butyryl-CoA:isobutyryl-CoA mutase; icmA (gene name); icmB (gene name); icmF (gene name) | |
| 5.4.99.14 | 4-carboxymethyl-4-methylbutenolide mutase | False | 0 | 0 | 3 | 6 | 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide | 4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase | None | 4-methyl-2-enelactone isomerase; 4-methylmuconolactone methylisomerase; 4-methyl-3-enelactone methyl isomerase | |
| 5.4.99.15 | (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase | False | 3 | 1508 | 3 | 14 | 4-[(1->4)-alpha-D-glucosyl]n-1-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl]n-1-alpha-D-glucopyranoside | (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase | None | malto-oligosyltrehalose synthase; maltodextrin alpha-D-glucosyltransferase | |
| 5.4.99.16 | maltose alpha-D-glucosyltransferase | False | 5 | 8439 | 5 | 29 | maltose = alpha,alpha-trehalose | maltose alpha-D-glucosylmutase | None | trehalose synthase; maltose glucosylmutase | |
| 5.4.99.17 | squalene---hopene cyclase | False | 5 | 3239 | 13 | 15 | squalene = hop-22(29)-ene | squalene mutase (cyclizing, hop-22(29)-ene-forming) | None | None | |
| 5.5.1.1 | muconate cycloisomerase | False | 6 | 734 | 13 | 20 | (+)-muconolactone = cis,cis-muconate | (+)-muconolactone lyase (ring-opening) | None | muconate cycloisomerase I; cis,cis-muconate-lactonizing enzyme; cis,cis-muconate cycloisomerase; muconate lactonizing enzyme; 4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing); CatB; MCI; 2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing); 2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | |
| 5.5.1.2 | 3-carboxy-cis,cis-muconate cycloisomerase | False | 4 | 4963 | 1 | 16 | 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate | 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | None | beta-carboxymuconate lactonizing enzyme; 3-carboxymuconolactone hydrolase; 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) | |
| 5.5.1.3 | tetrahydroxypteridine cycloisomerase | True | 0 | 0 | 0 | 1 | tetrahydroxypteridine = xanthine-8-carboxylate | tetrahydroxypteridine lyase (isomerizing) | None | None | |
| 5.5.1.4 | inositol-3-phosphate synthase | False | 37 | 11846 | 18 | 74 | D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate | 1D-myo-inositol-3-phosphate lyase (isomerizing) | None | myo-inositol-1-phosphate synthase; D-glucose 6-phosphate cycloaldolase; inositol 1-phosphate synthatase; glucose 6-phosphate cyclase; inositol 1-phosphate synthetase; glucose-6-phosphate inositol monophosphate cycloaldolase; glucocycloaldolase; 1L-myo-inositol-1-phosphate lyase (isomerizing) | |
| 5.5.1.5 | carboxy-cis,cis-muconate cyclase | False | 1 | 48 | 1 | 21 | 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate | 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | None | 3-carboxymuconate cyclase; 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) | |
| 5.5.1.6 | chalcone isomerase | False | 53 | 18 | 18 | 61 | a chalcone = a flavanone | flavanone lyase (ring-opening) | None | chalcone-flavanone isomerase; flavanone lyase (decyclizing) | |
| 5.5.1.7 | chloromuconate cycloisomerase | False | 6 | 77 | 4 | 9 | (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate | (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | None | muconate cycloisomerase II; 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing); 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | |
| 5.5.1.8 | (+)-bornyl diphosphate synthase | False | 1 | 1 | 7 | 5 | geranyl diphosphate = (+)-bornyl diphosphate | (+)-bornyl-diphosphate lyase (ring-opening) | None | bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (+)-bornylpyrophosphate cyclase; geranyl-diphosphate cyclase (ambiguous); (+)-bornyl-diphosphate lyase (decyclizing) | |
| 5.5.1.9 | cycloeucalenol cycloisomerase | False | 1 | 17 | 0 | 5 | cycloeucalenol = obtusifoliol | cycloeucalenol lyase (cyclopropane-ring opening) | None | cycloeucalenol---obtusifoliol isomerase; cycloeucalenol lyase (cyclopropane-decyclizing) | |
| 5.5.1.10 | alpha-pinene-oxide decyclase | False | 0 | 1 | 0 | 4 | alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal | alpha-pinene-oxide lyase (ring-opening) | None | alpha-pinene oxide lyase; alpha-pinene-oxide lyase (decyclizing) | |
| 5.5.1.11 | dichloromuconate cycloisomerase | True | 0 | 0 | 0 | 1 | 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate | 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) | None | 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) | |
| 5.5.1.12 | copalyl diphosphate synthase | False | 23 | 6 | 1 | 11 | geranylgeranyl diphosphate = (+)-copalyl diphosphate | (+)-copalyl-diphosphate lyase (ring-opening) | None | (+)-copalyl-diphosphate lyase (decyclizing) | |
| 5.5.1.13 | ent-copalyl diphosphate synthase | False | 18 | 171 | 3 | 25 | geranylgeranyl diphosphate = ent-copalyl diphosphate | ent-copalyl-diphosphate lyase (ring-opening) | None | ent-kaurene synthase A; ent-kaurene synthetase A; ent-CDP synthase; ent-copalyl-diphosphate lyase (decyclizing) | |
| 5.99.1.1 | thiocyanate isomerase | True | 0 | 0 | 0 | 1 | benzyl isothiocyanate = benzyl thiocyanate | benzyl-thiocyanate isomerase | None | isothiocyanate isomerase | |
| 6.1.1.1 | tyrosine---tRNA ligase | False | 550 | 56531 | 99 | 32 | ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr | L-tyrosine:tRNATyr ligase (AMP-forming) | None | None | |
| 6.1.1.2 | tryptophan---tRNA ligase | False | 171 | 59524 | 77 | 35 | ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp | L-tryptophan:tRNATrp ligase (AMP-forming) | None | tryptophanyl-tRNA synthetase; L-tryptophan-tRNATrp ligase (AMP-forming); tryptophanyl-transfer ribonucleate synthetase; tryptophanyl-transfer ribonucleic acid synthetase; tryptophanyl-transfer RNA synthetase; tryptophanyl ribonucleic synthetase; tryptophanyl-transfer ribonucleic synthetase; tryptophanyl-tRNA synthase; tryptophan translase; TrpRS | |
| 6.1.1.3 | threonine---tRNA ligase | False | 701 | 58012 | 83 | 33 | ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr | L-threonine:tRNAThr ligase (AMP-forming) | None | threonyl-tRNA synthetase; threonyl-transfer ribonucleate synthetase; threonyl-transfer RNA synthetase; threonyl-transfer ribonucleic acid synthetase; threonyl ribonucleic synthetase; threonine-transfer ribonucleate synthetase; threonine translase; threonyl-tRNA synthetase; TRS | |
| 6.1.1.4 | leucine---tRNA ligase | False | 764 | 62180 | 92 | 35 | ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu | L-leucine:tRNALeu ligase (AMP-forming) | None | leucyl-tRNA synthetase; leucyl-transfer ribonucleate synthetase; leucyl-transfer RNA synthetase; leucyl-transfer ribonucleic acid synthetase; leucine-tRNA synthetase; leucine translase | |
| 6.1.1.5 | isoleucine---tRNA ligase | False | 583 | 56950 | 26 | 21 | ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle | L-isoleucine:tRNAIle ligase (AMP-forming) | None | isoleucyl-tRNA synthetase; isoleucyl-transfer ribonucleate synthetase; isoleucyl-transfer RNA synthetase; isoleucine-transfer RNA ligase; isoleucine-tRNA synthetase; isoleucine translase | |
| 6.1.1.6 | lysine---tRNA ligase | False | 513 | 53513 | 69 | 53 | ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys | L-lysine:tRNALys ligase (AMP-forming) | None | lysyl-tRNA synthetase; lysyl-transfer ribonucleate synthetase; lysyl-transfer RNA synthetase; L-lysine-transfer RNA ligase; lysine-tRNA synthetase; lysine translase | |
| 6.1.1.7 | alanine---tRNA ligase | False | 717 | 59649 | 33 | 19 | ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla | L-alanine:tRNAAla ligase (AMP-forming) | None | alanyl-tRNA synthetase; alanyl-transfer ribonucleate synthetase; alanyl-transfer RNA synthetase; alanyl-transfer ribonucleic acid synthetase; alanine-transfer RNA ligase; alanine transfer RNA synthetase; alanine tRNA synthetase; alanine translase; alanyl-transfer ribonucleate synthase; AlaRS; Ala-tRNA synthetase | |
| 6.1.1.9 | valine---tRNA ligase | False | 342 | 61374 | 6 | 21 | ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal | L-valine:tRNAVal ligase (AMP-forming) | None | valyl-tRNA synthetase; valyl-transfer ribonucleate synthetase; valyl-transfer RNA synthetase; valyl-transfer ribonucleic acid synthetase; valine transfer ribonucleate ligase; valine translase | |
| 6.1.1.10 | methionine---tRNA ligase | False | 499 | 56078 | 107 | 39 | ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet | L-methionine:tRNAMet ligase (AMP-forming) | None | methionyl-tRNA synthetase; methionyl-transfer ribonucleic acid synthetase; methionyl-transfer ribonucleate synthetase; methionyl-transfer RNA synthetase; methionine translase; MetRS | |
| 6.1.1.11 | serine---tRNA ligase | False | 820 | 54403 | 56 | 31 | ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer | L-serine:tRNASer ligase (AMP-forming) | None | seryl-tRNA synthetase; SerRS; seryl-transfer ribonucleate synthetase; seryl-transfer RNA synthetase; seryl-transfer ribonucleic acid synthetase; serine translase | |
| 6.1.1.12 | aspartate---tRNA ligase | False | 310 | 24997 | 25 | 29 | ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp | L-aspartate:tRNAAsp ligase (AMP-forming) | None | aspartyl-tRNA synthetase; aspartyl ribonucleic synthetase; aspartyl-transfer RNA synthetase; aspartic acid translase; aspartyl-transfer ribonucleic acid synthetase; aspartyl ribonucleate synthetase | |
| 6.1.1.13 | D-alanine---poly(phosphoribitol) ligase | False | 0 | 692 | 11 | 5 | ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate) | D-alanine:poly(phosphoribitol) ligase (AMP-forming) | None | D-alanyl-poly(phosphoribitol) synthetase; D-alanine: membrane acceptor ligase; D-alanine-D-alanyl carrier protein ligase; D-alanine-membrane acceptor ligase; D-alanine-activating enzyme | |
| 6.1.1.14 | glycine---tRNA ligase | False | 859 | 73330 | 35 | 26 | ATP + glycine + tRNAGly = AMP + diphosphate + glycyl-tRNAGly | glycine:tRNAGly ligase (AMP-forming) | None | glycyl-tRNA synthetase; glycyl-transfer ribonucleate synthetase; glycyl-transfer RNA synthetase; glycyl-transfer ribonucleic acid synthetase; glycyl translase | |
| 6.1.1.15 | proline---tRNA ligase | False | 838 | 56173 | 52 | 45 | ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro | L-proline:tRNAPro ligase (AMP-forming) | None | prolyl-tRNA synthetase; prolyl-transferRNA synthetase; prolyl-transfer ribonucleate synthetase; proline translase; prolyl-transfer ribonucleic acid synthetase; prolyl-s-RNA synthetase; prolinyl-tRNA ligase | |
| 6.1.1.16 | cysteine---tRNA ligase | False | 740 | 57800 | 7 | 21 | ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys | L-cysteine:tRNACys ligase (AMP-forming) | None | cysteinyl-tRNA synthetase; cysteinyl-transferRNA synthetase; cysteinyl-transfer ribonucleate synthetase; cysteine translase | |
| 6.1.1.17 | glutamate---tRNA ligase | False | 886 | 56508 | 61 | 41 | ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu | L-glutamate:tRNAGlu ligase (AMP-forming) | None | glutamyl-tRNA synthetase; glutamyl-transfer ribonucleate synthetase; glutamyl-transfer RNA synthetase; glutamyl-transfer ribonucleic acid synthetase; glutamate-tRNA synthetase; glutamic acid translase | |
| 6.1.1.18 | glutamine---tRNA ligase | False | 154 | 26348 | 28 | 15 | ATP + L-glutamine + tRNAGln = AMP + diphosphate + L-glutaminyl-tRNAGln | L-glutamine:tRNAGln ligase (AMP-forming) | None | glutaminyl-tRNA synthetase; glutaminyl-transfer RNA synthetase; glutaminyl-transfer ribonucleate synthetase; glutamine-tRNA synthetase; glutamine translase; glutamate-tRNA ligase; glutaminyl ribonucleic acid; GlnRS | |
| 6.1.1.19 | arginine---tRNA ligase | False | 743 | 57090 | 19 | 21 | ATP + L-arginine + tRNAArg = AMP + diphosphate + L-arginyl-tRNAArg | L-arginine:tRNAArg ligase (AMP-forming) | None | arginyl-tRNA synthetase; arginyl-transfer ribonucleate synthetase; arginyl-transfer RNA synthetase; arginyl transfer ribonucleic acid synthetase; arginine-tRNA synthetase; arginine translase | |
| 6.1.1.20 | phenylalanine---tRNA ligase | False | 1008 | 106829 | 47 | 37 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe | L-phenylalanine:tRNAPhe ligase (AMP-forming) | None | phenylalanyl-tRNA synthetase; phenylalanyl-transfer ribonucleate synthetase; phenylalanine-tRNA synthetase; phenylalanyl-transfer RNA synthetase; phenylalanyl-tRNA ligase; phenylalanyl-transfer RNA ligase; L-phenylalanyl-tRNA synthetase; phenylalanine translase | |
| 6.1.1.21 | histidine---tRNA ligase | False | 703 | 53294 | 44 | 35 | ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis | L-histidine:tRNAHis ligase (AMP-forming) | None | histidyl-tRNA synthetase; histidyl-transfer ribonucleate synthetase; histidine translase | |
| 6.1.1.22 | asparagine---tRNA ligase | False | 287 | 28585 | 14 | 17 | ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn | L-asparagine:tRNAAsn ligase (AMP-forming) | None | asparaginyl-tRNA synthetase; asparaginyl-transfer ribonucleate synthetase; asparaginyl transfer RNA synthetase; asparaginyl transfer ribonucleic acid synthetase; asparagyl-transfer RNA synthetase; asparagine translase | |
| 6.1.1.23 | aspartate---tRNAAsn ligase | False | 437 | 27747 | 4 | 19 | ATP + L-aspartate + tRNAAsx = AMP + diphosphate + L-aspartyl-tRNAAsx | L-aspartate:tRNAAsx ligase (AMP-forming) | None | nondiscriminating aspartyl-tRNA synthetase | |
| 6.1.1.24 | glutamate---tRNAGln ligase | False | 6 | 1464 | 0 | 13 | ATP + L-glutamate + tRNAGlx = AMP + diphosphate + L-glutamyl-tRNAGlx | L-glutamate:tRNAGlx ligase (AMP-forming) | None | nondiscriminating glutamyl-tRNA synthetase | |
| 6.2.1.1 | acetate---CoA ligase | False | 211 | 54613 | 40 | 51 | ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA | acetate:CoA ligase (AMP-forming) | None | acetyl-CoA synthetase; acetyl activating enzyme; acetate thiokinase; acyl-activating enzyme; acetyl coenzyme A synthetase; acetic thiokinase; acetyl CoA ligase; acetyl CoA synthase; acetyl-coenzyme A synthase; short chain fatty acyl-CoA synthetase; short-chain acyl-coenzyme A synthetase; ACS | |
| 6.2.1.2 | medium-chain acyl-CoA ligase | False | 45 | 6608 | 8 | 14 | ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA | medium-chain fatty acid:CoA ligase (AMP-forming) | None | fadK (gene name); lvaE (gene name); butyryl-CoA synthetase; fatty acid thiokinase (medium chain); acyl-activating enzyme; fatty acid elongase; fatty acid activating enzyme; fatty acyl coenzyme A synthetase; butyrate---CoA ligase; butyryl-coenzyme A synthetase; L-(+)-3-hydroxybutyryl CoA ligase; short-chain acyl-CoA synthetase; medium-chain acyl-CoA synthetase; butanoate:CoA ligase (AMP-forming) | |
| 6.2.1.3 | long-chain-fatty-acid---CoA ligase | False | 90 | 56516 | 6 | 36 | ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA | long-chain fatty acid:CoA ligase (AMP-forming) | None | acyl-CoA synthetase; fatty acid thiokinase (long chain); acyl-activating enzyme; palmitoyl-CoA synthase; lignoceroyl-CoA synthase; arachidonyl-CoA synthetase; acyl coenzyme A synthetase; acyl-CoA ligase; palmitoyl coenzyme A synthetase; thiokinase; palmitoyl-CoA ligase; acyl-coenzyme A ligase; fatty acid CoA ligase; long-chain fatty acyl coenzyme A synthetase; oleoyl-CoA synthetase; stearoyl-CoA synthetase; long chain fatty acyl-CoA synthetase; long-chain acyl CoA synthetase; fatty acid elongase; LCFA synthetase; pristanoyl-CoA synthetase; ACS3; long-chain acyl-CoA synthetase I; long-chain acyl-CoA synthetase II; fatty acyl-coenzyme A synthetase; long-chain acyl-coenzyme A synthetase; FAA1 | |
| 6.2.1.4 | succinate---CoA ligase (GDP-forming) | False | 18 | 2675 | 18 | 26 | GTP + succinate + CoA = GDP + phosphate + succinyl-CoA | succinate:CoA ligase (GDP-forming) | None | succinyl-CoA synthetase (GDP-forming); succinyl coenzyme A synthetase (guanosine diphosphate-forming); succinate thiokinase (ambiguous); succinic thiokinase (ambiguous); succinyl coenzyme A synthetase (ambiguous); succinate-phosphorylating enzyme (ambiguous); P-enzyme; SCS (ambiguous); G-STK; succinyl coenzyme A synthetase (GDP-forming); succinyl CoA synthetase (ambiguous) | |
| 6.2.1.5 | succinate---CoA ligase (ADP-forming) | False | 583 | 74488 | 24 | 52 | ATP + succinate + CoA = ADP + phosphate + succinyl-CoA | succinate:CoA ligase (ADP-forming) | None | succinyl-CoA synthetase (ADP-forming); succinic thiokinase (ambiguous); succinate thiokinase (ambiguous); succinyl-CoA synthetase (ambiguous); succinyl coenzyme A synthetase (adenosine diphosphate-forming); succinyl coenzyme A synthetase (ambiguous); A-STK (adenin nucleotide-linked succinate thiokinase); STK (ambiguous); A-SCS | |
| 6.2.1.6 | glutarate---CoA ligase | False | 0 | 6 | 0 | 3 | ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA | glutarate:CoA ligase (ADP-forming) | None | glutaryl-CoA synthetase; glutaryl coenzyme A synthetase | |
| 6.2.1.7 | cholate---CoA ligase | False | 7 | 4 | 0 | 7 | (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA;;(2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA | cholate:CoA ligase (AMP-forming) | None | BAL; bile acid CoA ligase; bile acid coenzyme A ligase; choloyl-CoA synthetase; choloyl coenzyme A synthetase; cholic thiokinase; cholate thiokinase; cholic acid:CoA ligase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase; THCA-CoA ligase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate---CoA ligase; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming); cholyl-CoA synthetase; trihydroxycoprostanoyl-CoA synthetase | |
| 6.2.1.8 | oxalate---CoA ligase | False | 3 | 33 | 6 | 16 | ATP + oxalate + CoA = AMP + diphosphate + oxalyl-CoA | oxalate:CoA ligase (AMP-forming) | None | oxalyl-CoA synthetase; oxalyl coenzyme A synthetase | |
| 6.2.1.9 | malate---CoA ligase | False | 3 | 13 | 0 | 4 | ATP + malate + CoA = ADP + phosphate + malyl-CoA | malate:CoA ligase (ADP-forming) | None | malyl-CoA synthetase; malyl coenzyme A synthetase; malate thiokinase | |
| 6.2.1.10 | carboxylic acid---CoA ligase (GDP-forming) | True | 0 | 0 | 0 | 1 | GTP + a carboxylate + CoA = GDP + phosphate + acyl-CoA | carboxylic acid:CoA ligase (GDP-forming) | None | acyl-CoA synthetase (GDP-forming); acyl coenzyme A synthetase (guanosine diphosphate forming) | |
| 6.2.1.11 | biotin---CoA ligase | False | 0 | 4 | 0 | 3 | ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA | biotin:CoA ligase (AMP-forming) | None | biotinyl-CoA synthetase; biotin CoA synthetase; biotinyl coenzyme A synthetase | |
| 6.2.1.12 | 4-coumarate---CoA ligase | False | 44 | 4500 | 11 | 61 | ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA | 4-coumarate:CoA ligase (AMP-forming) | None | 4-coumaroyl-CoA synthetase; p-coumaroyl CoA ligase; p-coumaryl coenzyme A synthetase; p-coumaryl-CoA synthetase; p-coumaryl-CoA ligase; feruloyl CoA ligase; hydroxycinnamoyl CoA synthetase; 4-coumarate:coenzyme A ligase; caffeolyl coenzyme A synthetase; p-hydroxycinnamoyl coenzyme A synthetase; feruloyl coenzyme A synthetase; sinapoyl coenzyme A synthetase; 4-coumaryl-CoA synthetase; hydroxycinnamate:CoA ligase; p-coumaryl-CoA ligase; p-hydroxycinnamic acid:CoA ligase; 4CL | |
| 6.2.1.13 | acetate---CoA ligase (ADP-forming) | False | 8 | 2404 | 0 | 16 | ATP + acetate + CoA = ADP + phosphate + acetyl-CoA | acetate:CoA ligase (ADP-forming) | None | acetyl-CoA synthetase (ADP-forming); acetyl coenzyme A synthetase (adenosine diphosphate-forming); acetate thiokinase | |
| 6.2.1.14 | 6-carboxyhexanoate---CoA ligase | False | 52 | 744 | 8 | 14 | ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA | 6-carboxyhexanoate:CoA ligase (AMP-forming) | None | 6-carboxyhexanoyl-CoA synthetase; pimelyl-CoA synthetase | |
| 6.2.1.15 | arachidonate---CoA ligase | False | 37 | 3732 | 0 | 5 | ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA | arachidonate:CoA ligase (AMP-forming) | None | arachidonoyl-CoA synthetase | |
| 6.2.1.16 | acetoacetate---CoA ligase | False | 9 | 7292 | 0 | 7 | ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA | acetoacetate:CoA ligase (AMP-forming) | None | acetoacetyl-CoA synthetase | |
| 6.2.1.17 | propionate---CoA ligase | False | 20 | 6694 | 0 | 11 | ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA | propanoate:CoA ligase (AMP-forming) | None | propionyl-CoA synthetase | |
| 6.2.1.18 | citrate---CoA ligase | False | 0 | 3 | 0 | 5 | ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA | citrate:CoA ligase (ADP-forming) | None | citryl-CoA synthetase; citrate:CoA ligase; citrate thiokinase | |
| 6.2.1.19 | long-chain-fatty-acid---protein ligase | False | 4 | 81 | 0 | 5 | ATP + a long-chain fatty acid + [protein]-L-cysteine = AMP + diphosphate + a [protein]-S-(long-chain-acyl)-L-cysteine | long-chain-fatty-acid:protein ligase (AMP-forming) | None | luxE (gene name); acyl-protein synthetase; long-chain-fatty-acid---luciferin-component ligase | |
| 6.2.1.20 | long-chain-fatty-acid---[acyl-carrier-protein] ligase | False | 69 | 1970 | 3 | 11 | ATP + a long-chain fatty acid + an [acyl-carrier protein] = AMP + diphosphate + a long-chain acyl-[acyl-carrier protein] | long-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming) | None | acyl-[acyl-carrier-protein] synthetase (ambiguous); acyl-ACP synthetase (ambiguous); stearoyl-ACP synthetase; acyl-acyl carrier protein synthetase (ambiguous); long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming) | |
| 6.2.1.22 | [citrate (pro-3S)-lyase] ligase | False | 4 | 3204 | 0 | 7 | ATP + acetate + holo-[citrate (pro-3S)-lyase] = AMP + diphosphate + acetyl-[citrate (pro-3S)-lyase] | acetate:holo-[citrate-(pro-3S)-lyase] ligase (AMP-forming) | None | citrate lyase ligase; citrate lyase synthetase; acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP); acetate:HS-citrate lyase ligase; acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming); acetate:[citrate-(pro-3S)-lyase](thiol-form) ligase (AMP-forming) | |
| 6.2.1.23 | dicarboxylate---CoA ligase | False | 0 | 3 | 0 | 1 | ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA | omega-dicarboxylate:CoA ligase (AMP-forming) | None | carboxylyl-CoA synthetase; dicarboxylyl-CoA synthetase | |
| 6.2.1.24 | phytanate---CoA ligase | False | 7 | 1 | 0 | 2 | ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA | phytanate:CoA ligase (AMP-forming) | None | phytanoyl-CoA ligase | |
| 6.2.1.25 | benzoate---CoA ligase | False | 11 | 676 | 2 | 17 | ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA | benzoate:CoA ligase (AMP-forming) | None | benzoate---coenzyme A ligase; benzoyl-coenzyme A synthetase; benzoyl CoA synthetase (AMP forming) | |
| 6.2.1.26 | o-succinylbenzoate---CoA ligase | False | 48 | 6587 | 10 | 8 | ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA | 2-succinylbenzoate:CoA ligase (AMP-forming) | None | o-succinylbenzoyl-coenzyme A synthetase; o-succinylbenzoate:CoA ligase (AMP-forming) | |
| 6.2.1.27 | 4-hydroxybenzoate---CoA ligase | False | 3 | 146 | 0 | 7 | ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA | 4-hydroxybenzoate:CoA ligase (AMP-forming) | None | 4-hydroxybenzoate-CoA synthetase; 4-hydroxybenzoate---coenzyme A ligase (AMP-forming); 4-hydroxybenzoyl coenzyme A synthetase; 4-hydroxybenzoyl-CoA ligase | |
| 6.2.1.28 | 3alpha,7alpha-dihydroxy-5beta-cholestanate---CoA ligase | True | 0 | 0 | 0 | 1 | ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA | (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming) | None | 3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase; DHCA-CoA ligase; 3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming) | |
| 6.2.1.30 | phenylacetate---CoA ligase | False | 4 | 14214 | 3 | 14 | ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA | phenylacetate:CoA ligase (AMP-forming) | None | phenacyl coenzyme A synthetase; phenylacetyl-CoA ligase; PA-CoA ligase; phenylacetyl-CoA ligase (AMP-forming) | |
| 6.2.1.31 | 2-furoate---CoA ligase | False | 0 | 31 | 0 | 1 | ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA | 2-furoate:CoA ligase (AMP-forming) | None | 2-furoyl coenzyme A synthetase | |
| 6.2.1.32 | anthranilate---CoA ligase | False | 1 | 176 | 4 | 3 | ATP + anthranilate + CoA = AMP + diphosphate + anthraniloyl-CoA | anthranilate:CoA ligase (AMP-forming) | None | anthraniloyl coenzyme A synthetase; 2-aminobenzoate---CoA ligase; 2-aminobenzoate---coenzyme A ligase; 2-aminobenzoate coenzyme A ligase | |
| 6.2.1.33 | 4-chlorobenzoate---CoA ligase | False | 3 | 140 | 9 | 3 | 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate | 4-chlorobenzoate:CoA ligase | None | None | |
| 6.2.1.34 | trans-feruloyl-CoA synthase | False | 12 | 224 | 0 | 1 | ferulic acid + CoA + ATP = feruloyl-CoA + products of ATP breakdown | ferulate:CoA ligase (ATP-hydrolysing) | None | trans-feruloyl-CoA synthetase; trans-ferulate:CoASH ligase (ATP-hydrolysing); ferulate:CoASH ligase (ATP-hydrolysing) | |
| 6.3.1.1 | aspartate---ammonia ligase | False | 152 | 6621 | 3 | 10 | ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine | L-aspartate:ammonia ligase (AMP-forming) | None | asparagine synthetase; L-asparagine synthetase | |
| 6.3.1.2 | glutamine synthetase | False | 176 | 62515 | 75 | 143 | ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine | L-glutamate:ammonia ligase (ADP-forming) | None | glutamate---ammonia ligase; glutamylhydroxamic synthetase; L-glutamine synthetase; GS | |
| 6.3.1.4 | aspartate---ammonia ligase (ADP-forming) | True | 0 | 0 | 0 | 3 | ATP + L-aspartate + NH3 = ADP + phosphate + L-asparagine | L-aspartate:ammonia ligase (ADP-forming) | None | asparagine synthetase (ADP-forming); asparagine synthetase (adenosine diphosphate-forming) | |
| 6.3.1.5 | NAD+ synthase | False | 291 | 20602 | 23 | 15 | ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+ | deamido-NAD+:ammonia ligase (AMP-forming) | None | NAD synthetase; NAD synthase; nicotinamide adenine dinucleotide synthetase; diphosphopyridine nucleotide synthetase | |
| 6.3.1.6 | glutamate---ethylamine ligase | False | 1 | 2 | 0 | 1 | ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine | L-glutamate:ethylamine ligase (ADP-forming) | None | N5-ethyl-L-glutamine synthetase; theanine synthetase; N5-ethylglutamine synthetase | |
| 6.3.1.7 | 4-methyleneglutamate---ammonia ligase | True | 0 | 0 | 0 | 1 | ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine | 4-methylene-L-glutamate:ammonia ligase (AMP-forming) | None | 4-methyleneglutamine synthetase | |
| 6.3.1.8 | glutathionylspermidine synthase | False | 3 | 444 | 9 | 5 | glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate | gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule] | None | glutathione:spermidine ligase (ADP-forming) | |
| 6.3.1.9 | trypanothione synthase | False | 2 | 42 | 3 | 8 | (1) glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate;;(2) glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate | spermidine/glutathionylspermidine:glutathione ligase (ADP-forming) | None | glutathionylspermidine:glutathione ligase (ADP-forming) | |
| 6.3.1.10 | adenosylcobinamide-phosphate synthase | False | 0 | 113 | 0 | 4 | (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate;;(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide | adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming) | None | CbiB | |
| 6.3.1.11 | glutamate---putrescine ligase | False | 2 | 1144 | 1 | 1 | ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine | L-glutamate:putrescine ligase (ADP-forming) | None | gamma-glutamylputrescine synthetase; YcjK | |
| 6.3.2.1 | pantoate---beta-alanine ligase (AMP-forming) | False | 564 | 34728 | 70 | 9 | ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate | (R)-pantoate:beta-alanine ligase (AMP-forming) | None | pantothenate synthetase; pantoate activating enzyme; pantoic-activating enzyme; D-pantoate:beta-alanine ligase (AMP-forming); pantoate---beta-alanine ligase (ambiguous) | |
| 6.3.2.2 | glutamate---cysteine ligase | False | 337 | 41358 | 14 | 57 | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine | L-glutamate:L-cysteine gamma-ligase (ADP-forming) | None | gamma-glutamylcysteine synthetase; gamma-glutamyl-L-cysteine synthetase; gamma-glutamylcysteinyl synthetase | |
| 6.3.2.3 | glutathione synthase | False | 80 | 22184 | 14 | 42 | ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione | gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming) | None | glutathione synthetase; GSH synthetase | |
| 6.3.2.4 | D-alanine---D-alanine ligase | False | 587 | 46506 | 63 | 30 | ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine | D-alanine:D-alanine ligase (ADP-forming) | None | MurE synthetase [ambiguous]; alanine:alanine ligase (ADP-forming); alanylalanine synthetase | |
| 6.3.2.5 | phosphopantothenate---cysteine ligase (CTP) | False | 21 | 36423 | 12 | 13 | CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | (R)-4'-phosphopantothenate:L-cysteine ligase | None | phosphopantothenoylcysteine synthetase (ambiguous); phosphopantothenate---cysteine ligase (ambiguous) | |
| 6.3.2.6 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | False | 541 | 45966 | 50 | 20 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming) | None | phosphoribosylaminoimidazole-succinocarboxamide synthetase; PurC; SAICAR synthetase; 4-(N-succinocarboxamide)-5-aminoimidazole synthetase; 4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase; SAICARs; phosphoribosylaminoimidazolesuccinocarboxamide synthetase; 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase | |
| 6.3.2.7 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase | False | 38 | 1155 | 2 | 4 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming) | None | MurE synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase; uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase; UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming) | |
| 6.3.2.8 | UDP-N-acetylmuramate---L-alanine ligase | False | 679 | 39663 | 17 | 14 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | UDP-N-acetyl-alpha-D-muramate:L-alanine ligase (ADP-forming) | None | MurC synthetase; UDP-N-acetylmuramoyl-L-alanine synthetase; uridine diphospho-N-acetylmuramoylalanine synthetase; UDP-N-acetylmuramoylalanine synthetase; L-alanine-adding enzyme; UDP-acetylmuramyl-L-alanine synthetase; UDPMurNAc-L-alanine synthetase; L-Ala ligase; uridine diphosphate N-acetylmuramate:L-alanine ligase; uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase; uridine-diphosphate-N-acetylmuramate:L-alanine ligase; UDP-MurNAc:L-alanine ligase; alanine-adding enzyme; UDP-N-acetylmuramyl:L-alanine ligase; UDP-N-acetylmuramate:L-alanine ligase (ADP-forming) | |
| 6.3.2.9 | UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase | False | 475 | 40269 | 34 | 8 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate | UDP-N-acetyl-alpha-D-muramoyl-L-alanine:D-glutamate ligase (ADP-forming) | None | MurD synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase; D-glutamate-adding enzyme; D-glutamate ligase; UDP-Mur-NAC-L-Ala:D-Glu ligase; UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming); UDP-N-acetylmuramoylalanine---D-glutamate ligase; UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming) | |
| 6.3.2.10 | UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase | False | 18 | 37035 | 10 | 7 | ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming) | None | MurF synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase; UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase; uridine diphosphoacetylmuramoylpentapeptide synthetase; UDPacetylmuramoylpentapeptide synthetase; UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase | |
| 6.3.2.11 | carnosine synthase | False | 3 | 21 | 0 | 6 | ATP + L-histidine + beta-alanine = ADP + phosphate + carnosine | L-histidine:beta-alanine ligase (ADP-forming) | None | carnosine synthetase; carnosine-anserine synthetase; homocarnosine-carnosine synthetase; carnosine-homocarnosine synthetase; L-histidine:beta-alanine ligase (AMP-forming) (incorrect) | |
| 6.3.2.12 | dihydrofolate synthase | False | 10 | 9293 | 4 | 23 | ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate | 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) | None | dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS | |
| 6.3.2.13 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase | False | 147 | 33181 | 22 | 10 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming) | None | MurE synthetase [ambiguous]; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming); UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase; UDP-N-acetylmuramoylalanyl-D-glutamate---2,6-diaminopimelate ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming) | |
| 6.3.5.11 | cobyrinate a,c-diamide synthase | False | 42 | 9117 | 0 | 3 | 2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction);;(1a) ATP + cobyrinate + L-glutamine + H2O = ADP + phosphate + cobyrinate c-monamide + L-glutamate;;(1b) ATP + cobyrinate c-monamide + L-glutamine + H2O = ADP + phosphate + cobyrinate a,c-diamide + L-glutamate | cobyrinate:L-glutamine amido-ligase (ADP-forming) | None | cobyrinic acid a,c-diamide synthetase; CbiA | |
| 6.3.2.14 | enterobactin synthase | False | 8 | 1040 | 2 | 1 | 6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine = enterobactin + 6 AMP + 6 diphosphate | 2,3-dihydroxybenzoate:L-serine ligase | None | N-(2,3-dihydroxybenzoyl)-serine synthetase; 2,3-dihydroxybenzoylserine synthetase; 2,3-dihydroxybenzoate---serine ligase | |
| 6.3.2.16 | D-alanine---alanyl-poly(glycerolphosphate) ligase | True | 0 | 0 | 0 | 1 | ATP + D-alanine + alanyl-poly(glycerolphosphate) = ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate) | D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming) | None | D-alanyl-alanyl-poly(glycerolphosphate) synthetase; D-alanine:membrane-acceptor ligase; D-alanylalanylpoly(phosphoglycerol) synthetase; D-alanyl-poly(phosphoglycerol) synthetase; D-alanine-membrane acceptor-ligase | |
| 6.3.2.17 | tetrahydrofolate synthase | False | 33 | 47555 | 11 | 21 | ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming) | None | folylpolyglutamate synthase; folate polyglutamate synthetase; formyltetrahydropteroyldiglutamate synthetase; N10-formyltetrahydropteroyldiglutamate synthetase; folylpoly-gamma-glutamate synthase; folylpolyglutamyl synthetase; folylpoly(gamma-glutamate) synthase; folylpolyglutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) | |
| 1.1.3.49 | (R)-mandelonitrile oxidase | True | 0 | 0 | 0 | 1 | (R)-mandelonitrile + O2 = benzoyl cyanide + H2O2 | (R)-mandelonitrile:oxygen oxidoreductase | None | ChuaMOX (gene name) | |
| 6.3.2.18 | gamma-glutamylhistamine synthase | True | 0 | 0 | 0 | 1 | ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine | L-glutamate:histamine ligase | None | gamma-glutaminylhistamine synthetase; gamma-GHA synthetase | |
| 6.3.2.20 | indoleacetate---lysine synthetase | False | 1 | 8 | 0 | 2 | ATP + (indol-3-yl)acetate + L-lysine = ADP + phosphate + N6-[(indol-3-yl)acetyl]-L-lysine | (indol-3-yl)acetate:L-lysine ligase (ADP-forming) | None | indoleacetate:L-lysine ligase (ADP-forming) | |
| 6.3.2.23 | homoglutathione synthase | False | 0 | 1 | 1 | 9 | ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine | gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming) | None | homoglutathione synthetase; beta-alanine specific hGSH synthetase | |
| 6.3.2.24 | tyrosine---arginine ligase | True | 0 | 0 | 0 | 3 | ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine | L-tyrosine:L-arginine ligase (AMP-forming) | None | tyrosyl-arginine synthase; kyotorphin synthase; kyotorphin-synthesizing enzyme; kyotorphin synthetase | |
| 6.3.2.25 | tubulin---tyrosine ligase | False | 7 | 1219 | 4 | 10 | ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate | alpha-tubulin:L-tyrosine ligase (ADP-forming) | None | None | |
| 6.3.2.26 | N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase | False | 6 | 60 | 2 | 10 | 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O = 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine | L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting) | None | L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase; ACV synthetase; L-alpha-aminoadipyl-cysteinyl-valine synthetase; | |
| 6.3.3.1 | phosphoribosylformylglycinamidine cyclo-ligase | False | 489 | 43127 | 11 | 13 | ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole | 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | None | phosphoribosylaminoimidazole synthetase; AIR synthetase; 5'-aminoimidazole ribonucleotide synthetase; 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | |
| 6.3.3.2 | 5-formyltetrahydrofolate cyclo-ligase | False | 16 | 38701 | 9 | 17 | ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate | 5-formyltetrahydrofolate cyclo-ligase (ADP-forming) | None | 5,10-methenyltetrahydrofolate synthetase; formyltetrahydrofolic cyclodehydrase; 5-formyltetrahydrofolate cyclodehydrase | |
| 6.3.3.3 | dethiobiotin synthase | False | 258 | 22428 | 55 | 20 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin | 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming) | None | desthiobiotin synthase | |
| 6.3.3.4 | (carboxyethyl)arginine beta-lactam-synthase | False | 1 | 6 | 0 | 1 | ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate | L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) | None | L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) | |
| 6.3.4.2 | CTP synthase (glutamine hydrolysing) | False | 694 | 54412 | 60 | 16 | ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + UTP + NH3 = ADP + phosphate + CTP | UTP:L-glutamine amido-ligase (ADP-forming) | None | UTP---ammonia ligase; cytidine triphosphate synthetase; uridine triphosphate aminase; cytidine 5'-triphosphate synthetase; CTPS (gene name); pyrG (gene name); CTP synthase; UTP:ammonia ligase (ADP-forming) | |
| 6.3.4.3 | formate---tetrahydrofolate ligase | False | 313 | 26462 | 19 | 71 | ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate | formate:tetrahydrofolate ligase (ADP-forming) | None | formyltetrahydrofolate synthetase; 10-formyltetrahydrofolate synthetase; tetrahydrofolic formylase; tetrahydrofolate formylase | |
| 6.3.4.4 | adenylosuccinate synthase | False | 828 | 50791 | 51 | 37 | GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP | IMP:L-aspartate ligase (GDP-forming) | None | IMP---aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase | |
| 6.3.4.5 | argininosuccinate synthase | False | 607 | 42523 | 20 | 20 | ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate | L-citrulline:L-aspartate ligase (AMP-forming) | None | citrulline---aspartate ligase; argininosuccinate synthetase; arginine succinate synthetase; argininosuccinic acid synthetase; arginosuccinate synthetase | |
| 6.3.4.6 | urea carboxylase | False | 3 | 1546 | 1 | 34 | ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate | urea:carbon-dioxide ligase (ADP-forming) | None | urease (ATP-hydrolysing); urea carboxylase (hydrolysing); ATP---urea amidolyase; urea amidolyase; UALase; UCA | |
| 6.3.4.7 | ribose-5-phosphate---ammonia ligase | True | 0 | 0 | 0 | 7 | ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine | ribose-5-phosphate:ammonia ligase (ADP-forming) | None | 5-phosphoribosylamine synthetase; ribose 5-phosphate aminotransferase; ammonia-ribose 5-phosphate aminotransferase | |
| 6.3.4.8 | imidazoleacetate---phosphoribosyldiphosphate ligase | True | 0 | 0 | 0 | 1 | ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate + H2O = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate | imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming) | None | 5-phosphoribosylimidazoleacetate synthetase | |
| 6.3.4.9 | biotin---[methylmalonyl-CoA-carboxytransferase] ligase | False | 4 | 89 | 0 | 1 | ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] = AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase] | biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming) | None | biotin-[methylmalonyl-CoA-carboxyltransferase] synthetase; biotin-methylmalonyl coenzyme A carboxyltransferase synthetase; biotin-transcarboxylase synthetase; methylmalonyl coenzyme A holotranscarboxylase synthetase; biotin---[methylmalonyl-CoA-carboxyltransferase] ligase; biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase (AMP-forming) | |
| 6.3.4.10 | biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase | False | 4 | 32 | 0 | 11 | ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming) | None | biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase; biotin-propionyl coenzyme A carboxylase synthetase; propionyl coenzyme A holocarboxylase synthetase | |
| 6.3.4.11 | biotin---[methylcrotonoyl-CoA-carboxylase] ligase | False | 5 | 30 | 0 | 2 | ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] | biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming) | None | biotin-[methylcrotonoyl-CoA-carboxylase] synthetase; biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase; beta-methylcrotonyl coenzyme A holocarboxylase synthetase; holocarboxylase-synthetase | |
| 6.3.4.12 | glutamate---methylamine ligase | False | 2 | 109 | 0 | 4 | ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine | L-glutamate:methylamine ligase (ADP-forming) | None | gamma-glutamylmethylamide synthetase | |
| 6.3.4.13 | phosphoribosylamine---glycine ligase | False | 118 | 44989 | 30 | 31 | ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide | 5-phospho-D-ribosylamine:glycine ligase (ADP-forming) | None | phosphoribosylglycinamide synthetase; glycinamide ribonucleotide synthetase; phosphoribosylglycineamide synthetase; glycineamide ribonucleotide synthetase; 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase; 5'-phosphoribosylglycinamide synthetase; GAR | |
| 6.3.4.14 | biotin carboxylase | False | 33 | 44222 | 44 | 52 | ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine | [biotin carboxyl-carrier protein]-biotin-N6-L-lysine:hydrogencarbonate ligase (ADP-forming) | None | accC (gene name); biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) | |
| 6.3.4.15 | biotin---[biotin carboxyl-carrier protein] ligase | False | 16 | 35234 | 61 | 21 | ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine | biotin:apo-[carboxyl-carrier protein] ligase (AMP-forming) | None | birA (gene name); HLCS (gene name); HCS1 (gene name); biotin-[acetyl-CoA carboxylase] synthetase; biotin-[acetyl coenzyme A carboxylase] synthetase; acetyl coenzyme A holocarboxylase synthetase; acetyl CoA holocarboxylase synthetase; biotin:apocarboxylase ligase; Biotin holoenzyme synthetase; biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming); biotin---[acetyl-CoA-carboxylase] ligase | |
| 6.3.4.16 | carbamoyl-phosphate synthase (ammonia) | False | 270 | 35069 | 6 | 22 | 2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate (overall reaction);;(1a) ATP + hydrogencarbonate = ADP + carboxyphosphate;;(1b) NH3 + carboxyphosphate = carbamate + phosphate;;(1c) ATP + carbamate = ADP + carbamoyl phosphate | hydrogencarbonate:ammonia ligase (ADP-forming, carbamate-phosphorylating) | None | carbon-dioxide---ammonia ligase; carbamoylphosphate synthase; carbamylphosphate synthetase; carbamoylphosphate synthase (ammonia); carbamoylphosphate synthetase; carbamylphosphate synthetase I; CPSI (gene name); carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating) | |
| 6.3.4.17 | formate---dihydrofolate ligase | True | 0 | 0 | 0 | 2 | ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate | formate:dihydrofolate ligase (ADP-forming) | None | formyltransferase, dihydrofolate; dihydrofolate formyltransferase; formyl dihydrofolate synthase | |
| 6.3.5.1 | NAD+ synthase (glutamine-hydrolysing) | False | 25 | 32251 | 17 | 10 | ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate | deamido-NAD+:L-glutamine amido-ligase (AMP-forming) | None | NAD synthetase (glutamine-hydrolysing); nicotinamide adenine dinucleotide synthetase (glutamine); desamidonicotinamide adenine dinucleotide amidotransferase; DPN synthetase | |
| 6.3.5.2 | GMP synthase (glutamine-hydrolysing) | False | 663 | 51807 | 27 | 21 | ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + XMP + NH3 = AMP + diphosphate + GMP | xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) | None | GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase | |
| 6.3.5.3 | phosphoribosylformylglycinamidine synthase | False | 531 | 79862 | 28 | 16 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate | N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) | None | phosphoribosylformylglycinamidine synthetase; formylglycinamide ribonucleotide amidotransferase; phosphoribosylformylglycineamidine synthetase; FGAM synthetase; FGAR amidotransferase; 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming); 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) | |
| 6.3.5.4 | asparagine synthase (glutamine-hydrolysing) | False | 36 | 63466 | 3 | 44 | ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine | L-aspartate:L-glutamine amido-ligase (AMP-forming) | None | asparagine synthetase (glutamine-hydrolysing); glutamine-dependent asparagine synthetase; asparagine synthetase B; AS; AS-B | |
| 6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) | False | 465 | 89013 | 42 | 43 | 2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + hydrogencarbonate = ADP + carboxyphosphate;;(1c) NH3 + carboxyphosphate = carbamate + phosphate;;(1d) ATP + carbamate = ADP + carbamoyl phosphate;; | hydrogencarbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) | None | carbamoyl-phosphate synthetase (glutamine-hydrolysing); carbamyl phosphate synthetase (glutamine); carbamoylphosphate synthetase II; glutamine-dependent carbamyl phosphate synthetase; carbamoyl phosphate synthetase; CPS; carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating); carA (gene name); carB (gene name); CAD (gene name); hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) | |
| 6.3.5.6 | asparaginyl-tRNA synthase (glutamine-hydrolysing) | False | 0 | 1453 | 0 | 18 | ATP + L-aspartyl-tRNAAsn + L-glutamine + H2O = ADP + phosphate + L-asparaginyl-tRNAAsn + L-glutamate;;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + L-aspartyl-tRNAAsn = ADP + 4-phosphooxy-L-aspartyl-tRNAAsn;;(1c) 4-phosphooxy-L-aspartyl-tRNAAsn + NH3 = L-asparaginyl-tRNAAsn + phosphate | L-aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming) | None | Asp-AdT; Asp-tRNAAsn amidotransferase; aspartyl-tRNAAsn amidotransferase; Asn-tRNAAsn:L-glutamine amido-ligase (ADP-forming); aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming); GatCAB | |
| 6.3.5.7 | glutaminyl-tRNA synthase (glutamine-hydrolysing) | False | 608 | 40029 | 2 | 16 | ATP + L-glutamyl-tRNAGln + L-glutamine = ADP + phosphate + L-glutaminyl-tRNAGln + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + L-glutamyl-tRNAGln = ADP + 5-phosphooxy-L-glutamyl-tRNAGln;;(1c) 5-phosphooxy-L-glutamyl-tRNAGln + NH3 = L-glutaminyl-tRNAGln + phosphate | L-glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming) | None | Glu-AdT; Glu-tRNAGln amidotransferase; glutamyl-tRNAGln amidotransferase; Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming); GatCAB; GatFAB; GatDE | |
| 6.3.5.9 | hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) | False | 17 | 5803 | 0 | 3 | 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate | hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming) | None | CobB | |
| 6.3.5.10 | adenosylcobyric acid synthase (glutamine-hydrolysing) | False | 0 | 112 | 1 | 4 | 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate | adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming) | None | CobQ; cobyric acid synthase; 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase; Ado-cobyric acid synthase [glutamine hydrolyzing] | |
| 6.4.1.1 | pyruvate carboxylase | False | 20 | 18267 | 42 | 56 | ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate | pyruvate:carbon-dioxide ligase (ADP-forming) | None | pyruvic carboxylase | |
| 6.4.1.2 | acetyl-CoA carboxylase | False | 22 | 10444 | 57 | 81 | ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA | acetyl-CoA:hydrogencarbonate ligase (ADP-forming) | None | HFA1 (gene name); ACC1 (gene name); acetyl coenzyme A carboxylase; acetyl-CoA:carbon-dioxide ligase (ADP-forming) | |
| 6.4.1.3 | propionyl-CoA carboxylase | False | 21 | 12694 | 21 | 36 | ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA | propanoyl-CoA:carbon-dioxide ligase (ADP-forming) | None | propionyl coenzyme A carboxylase | |
| 6.4.1.4 | methylcrotonoyl-CoA carboxylase | False | 14 | 6849 | 18 | 24 | ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA | 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) | None | methylcrotonyl coenzyme A carboxylase; beta-methylcrotonyl coenzyme A carboxylase; beta-methylcrotonyl CoA carboxylase; methylcrotonyl-CoA carboxylase | |
| 6.4.1.5 | geranoyl-CoA carboxylase | False | 0 | 136 | 0 | 8 | ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA | geranoyl-CoA:carbon-dioxide ligase (ADP-forming) | None | geranoyl coenzyme A carboxylase; geranyl-CoA carboxylase | |
| 6.4.1.6 | acetone carboxylase | False | 3 | 499 | 3 | 8 | acetone + hydrogen carbonate + 2 ATP + 3 H2O = acetoacetate + 2 AMP + 4 phosphate | acetone:carbon-dioxide ligase (AMP-forming) | None | None | |
| 6.5.1.1 | DNA ligase (ATP) | False | 186 | 50662 | 63 | 118 | ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate (overall reaction);;(1a) ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;;(1b) [DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(1c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP) | None | polydeoxyribonucleotide synthase (ATP); polynucleotide ligase (ambiguous); sealase; DNA repair enzyme (ambiguous); DNA joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleate ligase (ambiguous); DNA-joining enzyme (ambiguous); deoxyribonucleic-joining enzyme (ambiguous); deoxyribonucleic acid-joining enzyme (ambiguous); deoxyribonucleic repair enzyme (ambiguous); deoxyribonucleic joinase (ambiguous); deoxyribonucleic acid ligase (ambiguous); deoxyribonucleic acid joinase (ambiguous); deoxyribonucleic acid repair enzyme (ambiguous); poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) | |
| 6.5.1.2 | DNA ligase (NAD+) | False | 876 | 48847 | 47 | 62 | NAD + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide (overall reaction);;(1a) NAD + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + beta-nicotinamide D-nucleotide;;(1b) [DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(1c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (NAD+) | None | polydeoxyribonucleotide synthase (NAD+); polynucleotide ligase (NAD+); DNA repair enzyme (ambiguous); DNA joinase (ambiguous); polynucleotide synthetase (nicotinamide adenine dinucleotide); deoxyribonucleic-joining enzyme (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleic repair enzyme (ambiguous); deoxyribonucleic joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleate ligase (ambiguous); polynucleotide ligase (ambiguous); deoxyribonucleic acid ligase (ambiguous); polynucleotide synthetase (ambiguous); deoxyribonucleic acid joinase (ambiguous); DNA-joining enzyme (ambiguous); polynucleotide ligase (nicotinamide adenine dinucleotide); poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) | |
| 6.5.1.3 | RNA ligase (ATP) | False | 18 | 3529 | 20 | 19 | ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate (overall reaction);;(1a) ATP + [RNA ligase]-L-lysine = [RNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;;(1b) [RNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(ribonucleotide)m = 5'-(5'-diphosphoadenosine)-(ribonucleotide)m + [RNA ligase]-L-lysine;;(1c) (ribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(ribonucleotide)m = (ribonucleotide)n+m + AMP | poly(ribonucleotide)-3'-hydroxyl:5'-phospho-poly(ribonucleotide) ligase (ATP) | None | polyribonucleotide synthase (ATP); RNA ligase; polyribonucleotide ligase; ribonucleic ligase; poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) | |
| 6.5.1.4 | RNA 3'-terminal-phosphate cyclase (ATP) | False | 90 | 6845 | 9 | 20 | ATP + [RNA]-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside (overall reaction);;(1a) ATP + [RNA 3'-phosphate cyclase]-L-histidine = [RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate;;(1b) [RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside) = [RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine);;(1c) [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine) = [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP | RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming) | None | rtcA (gene name); RNA cyclase (ambiguous); RNA-3'-phosphate cyclase (ambiguous) | |
| 6.6.1.1 | magnesium chelatase | False | 46 | 9989 | 6 | 17 | ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+ | Mg-protoporphyrin IX magnesium-lyase | None | protoporphyrin IX magnesium-chelatase; protoporphyrin IX Mg-chelatase; magnesium-protoporphyrin IX chelatase; magnesium-protoporphyrin chelatase; magnesium-chelatase; Mg-chelatase; Mg-protoporphyrin IX magnesio-lyase | |
| 6.6.1.2 | cobaltochelatase | False | 4 | 15113 | 1 | 5 | ATP + hydrogenobyrinate a,c-diamide + Co2+ + H2O = ADP + phosphate + cob(II)yrinate a,c-diamide + H+ | hydrogenobyrinate-a,c-diamide:cobalt cobalt-ligase (ADP-forming) | None | hydrogenobyrinic acid a,c-diamide cobaltochelatase; CobNST; CobNCobST; hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming) | |
| 1.1.3.2 | L-lactate oxidase | False | 0 | 0 | 3 | 7 | (S)-lactate + O2 = pyruvate + H2O2 | (S)-lactate:oxygen 2-oxidoreductase | None | lctO (gene name); LOX | |
| 2.7.11.3 | dephospho-[reductase kinase] kinase | True | 0 | 0 | 0 | 2 | ATP + dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} = ADP + {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} | ATP:dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} phosphotransferase | None | AMP-activated kinase; AMP-activated protein kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating); reductase kinase; reductase kinase kinase; STK30 | |
| 2.7.10.1 | receptor protein-tyrosine kinase | False | 322 | 70325 | 1387 | 43 | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) | None | AATK; AATYK; AATYK2; AATYK3; ACH; ALK; anaplastic lymphoma kinase; ARK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); AXL; Bek; Bfgfr; BRT; Bsk; C-FMS; CAK; CCK4; CD115; CD135; CDw135; Cek1; Cek10; Cek11; Cek2; Cek3; Cek5; Cek6; Cek7; CFD1; CKIT; CSF1R; DAlk; DDR1; DDR2; Dek; DKFZp434C1418; Drosophila Eph kinase; DRT; DTK; Ebk; ECK; EDDR1; Eek; EGFR; Ehk2; Ehk3; Elk; EPH; EPHA1; EPHA2; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EphB5; ephrin-B3 receptor tyrosine kinase; EPHT; EPHT2; EPHT3; EPHX; ERBB; ERBB1; ERBB2; ERBB3; ERBB4; ERK; Eyk; FGFR1; FGFR2; FGFR3; FGFR4; FLG; FLK1; FLK2; FLT1; FLT2; FLT3; FLT4; FMS; Fv2; HBGFR; HEK11; HEK2; HEK3; HEK5; HEK6; HEP; HER2; HER3; HER4; HGFR; HSCR1; HTK; IGF1R; INSR; INSRR; insulin receptor protein-tyrosine kinase; IR; IRR; JTK12; JTK13; JTK14; JWS; K-SAM; KDR; KGFR; KIA0641; KIAA1079; KIAA1459; Kil; Kin15; Kin16; KIT; KLG; LTK; MCF3; Mdk1; Mdk2; Mdk5; MEhk1; MEN2A/B; Mep; MER; MERTK; MET; Mlk1; Mlk2; Mrk; MST1R; MTC1; MUSK; Myk1; N-SAM; NEP; NET; Neu; neurite outgrowth regulating kinase; NGL; NOK; nork; novel oncogene with kinase-domain; Nsk2; NTRK1; NTRK2; NTRK3; NTRK4; NTRKR1; NTRKR2; NTRKR3; Nuk; NYK; PCL; PDGFR; PDGFRA; PDGFRB; PHB6; protein-tyrosine kinase (ambiguous); protein tyrosine kinase (ambiguous); PTK; PTK3; PTK7; receptor protein tyrosine kinase; RET; RON; ROR1; ROR2; ROS1; RSE; RTK; RYK; SEA; Sek2; Sek3; Sek4; Sfr; SKY; STK (ambiguous); STK1; TEK; TIE; TIE1; TIE2; TIF; TKT; TRK; TRKA; TRKB; TRKC; TRKE; TYK1; TYRO10; Tyro11; TYRO3; Tyro5; Tyro6; TYRO7; UFO; VEGFR1; VEGFR2; VEGFR3; Vik; YK1; Yrk | |
| 2.7.10.2 | non-specific protein-tyrosine kinase | False | 230 | 68778 | 1076 | 40 | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | None | ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); BLK; Bmk; BMX; BRK; Bruton's tyrosine kinase; Bsk; BTK; BTKL; CAKb; Cdgip; CHK; CSK; CTK; CYL; cytoplasmic protein tyrosine kinase; EMT; ETK; Fadk; FAK; FAK2; FER; Fert1/2; FES; FGR; focal adhesion kinase; FPS; FRK; FYN; HCK; HCTK; HYL; IMD1; ITK; IYK; JAK1; JAK2; JAK3; Janus kinase 1; Janus kinase 2; Janus kinase 3; JTK1; JTK9; L-JAK; LCK; LSK; LYN; MATK; Ntk; p60c-src protein tyrosine kinase; PKB; protein-tyrosine kinase (ambiguous); PSCTK; PSCTK1; PSCTK2; PSCTK4; PSCTK5; PTK2; PTK2B; PTK6; PYK2; RAFTK; RAK; Rlk; Sik; SLK; SRC; SRC2; SRK; SRM; SRMS; STD; SYK; SYN; Tck; TEC; TNK1; Tsk; TXK; TYK2; TYK3; YES1; YK2; ZAP70 | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | False | 2650 | 748211 | 2870 | 66 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (non-specific) | None | A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; protein kinase (phosphorylating); protein kinase A; protein kinase CK2; protein kinase p58; protein phosphokinase; protein serine kinase; protein serine-threonine kinase; protein-aspartyl kinase; protein-cysteine kinase; protein-serine kinase; Prp4 protein kinase; Raf kinase; Raf-1; ribosomal protein S6 kinase II; ribosomal S6 protein kinase; serine kinase; serine protein kinase; serine-specific protein kinase; serine(threonine) protein kinase; serine/threonine protein kinase; STK32; T-antigen kinase; threonine-specific protein kinase; twitchin kinase; type-2 casein kinase; betaIIPKC; epsilon PKC; Wee 1-like kinase; Wee-kinase; WEE1Hu | |
| 2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase | False | 20 | 132 | 44 | 19 | ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate | ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase | None | PDH kinase; PDHK; PDK; PDK1; PDK2; PDK3; PDK4; pyruvate dehydrogenase kinase; pyruvate dehydrogenase kinase (phosphorylating); pyruvate dehydrogenase kinase activator protein; STK1 | |
| 2.7.11.4 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase | False | 4 | 0 | 20 | 6 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase | None | BCK; BCKD kinase; BCODH kinase; branched-chain alpha-ketoacid dehydrogenase kinase; branched-chain 2-oxo acid dehydrogenase kinase; branched-chain keto acid dehydrogenase kinase; branched-chain oxo acid dehydrogenase kinase (phosphorylating); STK2 | |
| 2.7.11.5 | [isocitrate dehydrogenase (NADP+)] kinase | False | 122 | 5376 | 4 | 3 | ATP + [isocitrate dehydrogenase (NADP+)] = ADP + [isocitrate dehydrogenase (NADP+)] phosphate | ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase | None | [isocitrate dehydrogenase (NADP+)] kinase; ICDH kinase/phosphatase; IDH kinase; IDH kinase/phosphatase; IDH-K/P; IDHK/P; isocitrate dehydrogenase kinase (phosphorylating); isocitrate dehydrogenase kinase/phosphatase; STK3 | |
| 2.7.11.6 | [tyrosine 3-monooxygenase] kinase | True | 0 | 0 | 0 | 1 | ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase] | ATP:[tyrosine-3-monooxygenase] phosphotransferase | None | pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating) | |
| 2.7.11.7 | myosin-heavy-chain kinase | False | 4 | 255 | 11 | 4 | ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate | ATP:[myosin heavy-chain] O-phosphotransferase | None | ATP:myosin-heavy-chain O-phosphotransferase; calmodulin-dependent myosin heavy chain kinase; MHCK; MIHC kinase; myosin heavy chain kinase; myosin I heavy-chain kinase; myosin II heavy-chain kinase; [myosin-heavy-chain] kinase; myosin heavy chain kinase A; STK6 | |
| 2.7.11.8 | Fas-activated serine/threonine kinase | False | 2 | 2 | 0 | 2 | ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein] | ATP:[Fas-activated serine/threonine protein] phosphotransferase | None | FAST; FASTK; STK10 | |
| 2.7.11.9 | Goodpasture-antigen-binding protein kinase | False | 0 | 11 | 0 | 5 | ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein] | ATP:[Goodpasture antigen-binding protein] phosphotransferase | None | GPBPK; GPBP kinase; STK11; Goodpasture antigen-binding protein kinase | |
| 2.7.11.10 | IkappaB kinase | False | 14 | 3276 | 9 | 7 | ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein] | ATP:[IkappaB protein] phosphotransferase | None | CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFkappaB kinase; inhibitor of NF-kappaB kinase; STK12; TANK-binding kinase 1; TBK1 | |
| 2.7.11.11 | cAMP-dependent protein kinase | False | 28 | 3704 | 293 | 43 | ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent) | None | PKA; protein kinase A; PKA catalytic (C) subunit; A kinase; ATP:protein phosphotransferase (cAMP-dependent) | |
| 2.7.11.12 | cGMP-dependent protein kinase | False | 18 | 5217 | 31 | 30 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (cGMP-dependent) | None | 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Ibeta; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1alpha; PKG 1beta; PKG II; STK23 | |
| 2.7.11.13 | protein kinase C | False | 87 | 24225 | 57 | 25 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (diacylglycerol-dependent) | None | calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCalpha; cPKCbeta; cPKCgamma; nPKCdelta; nPKCepsilon; nPKC; nPKC; PKC; PKCalpha; PKCbeta; PKCgamma; PKCdelta; PKCepsilon; PKCzeta; Pkc1p; protein kinase Cepsilon; STK24 | |
| 2.7.11.14 | rhodopsin kinase | False | 12 | 98 | 16 | 15 | ATP + rhodopsin = ADP + phosphorhodopsin | ATP:rhodopsin phosphotransferase | None | cone opsin kinase; G-protein-coupled receptor kinase 1; GPCR kinase 1; GRK1; GRK7; opsin kinase; opsin kinase (phosphorylating); rhodopsin kinase (phosphorylating); RK; STK14 | |
| 2.7.11.15 | beta-adrenergic-receptor kinase | False | 10 | 44 | 32 | 10 | ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] | ATP:[beta-adrenergic receptor] phosphotransferase | None | ATP:beta-adrenergic-receptor phosphotransferase; [beta-adrenergic-receptor] kinase; beta-adrenergic receptor-specific kinase; beta-AR kinase; beta-ARK; beta-ARK 1; beta-ARK 2; beta-receptor kinase; GRK2; GRK3; beta-adrenergic-receptor kinase (phosphorylating); beta2ARK; betaARK1; beta-adrenoceptor kinase; beta-adrenoceptor kinase 1; beta-adrenoceptor kinase 2; ADRBK1; BARK1; adrenergic receptor kinase; STK15 | |
| 2.7.11.16 | G-protein-coupled receptor kinase | False | 15 | 45 | 7 | 5 | ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate | ATP:[G-protein-coupled receptor] phosphotransferase | None | G protein-coupled receptor kinase; GPCR kinase; GPCRK; GRK4; GRK5; GRK6; STK16 | |
| 2.7.11.17 | Ca2+/calmodulin-dependent protein kinase | False | 64 | 13216 | 118 | 38 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) | None | ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase; Ca2+/calmodulin-dependent protein kinase 1; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase kinase; Ca2+/calmodulin-dependent protein kinase kinase beta; calmodulin-dependent kinase II; CaM kinase; CaM kinase II; CAM PKII; CaM-regulated serine/threonine kinase; CaMKI; CaMKII; CaMKIV; CaMKKalpha; CaMKKbeta; microtubule-associated protein 2 kinase; STK20 | |
| 2.7.11.18 | myosin-light-chain kinase | False | 24 | 1265 | 8 | 19 | ATP + [myosin light chain] = ADP + [myosin light chain] phosphate | ATP:[myosin light chain] O-phosphotransferase | None | [myosin-light-chain] kinase; ATP:myosin-light-chain O-phosphotransferase; calcium/calmodulin-dependent myosin light chain kinase; MLCK; MLCKase; myosin kinase; myosin light chain kinase; myosin light chain protein kinase; myosin light-chain kinase (phosphorylating); smooth-muscle-myosin-light-chain kinase; STK18 | |
| 2.7.11.19 | phosphorylase kinase | False | 8 | 2314 | 6 | 23 | 2 ATP + phosphorylase b = 2 ADP + phosphorylase a | ATP:phosphorylase-b phosphotransferase | None | dephosphophosphorylase kinase; glycogen phosphorylase kinase; PHK; phosphorylase b kinase; phosphorylase B kinase; phosphorylase kinase (phosphorylating); STK17 | |
| 2.7.11.20 | elongation factor 2 kinase | False | 4 | 1050 | 8 | 8 | ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate | ATP:[elongation factor 2] phosphotransferase | None | Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19 | |
| 2.7.11.21 | polo kinase | False | 45 | 6579 | 111 | 16 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (spindle-pole-dependent) | None | Cdc5; Cdc5p; Plk; PLK; Plk1; Plo1; POLO kinase; polo serine-threonine kinase; polo-like kinase; polo-like kinase 1; serine/threonine-specific Drosophila kinase polo; STK21 | |
| 2.7.11.22 | cyclin-dependent kinase | False | 268 | 18630 | 481 | 48 | ATP + a protein = ADP + a phosphoprotein | ATP:cyclin phosphotransferase | None | Bur1; Bur1 Cdk; Cak1; Cak1p; cdc2; cdc2 kinase; Cdc28p; CDK; cdk-activating kinase; Cdk-activating protein kinase; cdk1; cdk2; Cdk2; cdk3; cdk4; cdk5; cdk6; cdk7; cdk8; cdk9; cyclin A-activated cdc2; cyclin A-activated cdk2; cyclin D-cdk6 kinase; cyclin D-dependent kinase; cyclin E kinase; cyclin-A associated kinase; cyclin-dependent kinase 6; cyclin-dependent kinase-2; cyclin-dependent kinase-4; cyclin-dependent protein kinase activating kinase; cyk; D-type cyclin kinase; nclk; neuronal cdc2-like kinase; PCTAIRE-1; STK25 | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | False | 159 | 12259 | 5 | 12 | ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase] | ATP:[DNA-directed RNA polymerase] phosphotransferase | None | CTD kinase; STK9 | |
| 2.7.11.24 | mitogen-activated protein kinase | False | 227 | 30076 | 651 | 48 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (MAPKK-activated) | None | c-Jun N-terminal kinase; Dp38; ERK; ERK1; ERK2; extracellular signal-regulated kinase; JNK; JNK3alpha1; LeMPK3; MAP kinase; MAP-2 kinase; MAPK; MBP kinase I; MBP kinase II; microtubule-associated protein 2 kinase; microtubule-associated protein kinase; myelin basic protein kinase; p38delta; p38-2; p42 mitogen-activated protein kinase; p42mapk; PMK-1; PMK-2; PMK-3; pp42; pp44mapk; p44mpk; SAPK; STK26; stress-activated protein kinase | |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase | False | 80 | 16834 | 98 | 29 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (MAPKKKK-activated) | None | cMos; cRaf; MAPKKK; MAP3K; MAP kinase kinase kinase; MEKK; MEKK1; MEKK2; MEKK3; MEK kinase; Mil/Raf; MLK-like mitogen-activated protein triple kinase; MLTK; MLTKa; MLTKb; REKS; STK28 | |
| 2.7.11.26 | tau-protein kinase | False | 43 | 3263 | 80 | 18 | ATP + [tau-protein] = ADP + O-phospho-[tau-protein] | ATP:[tau-protein] O-phosphotransferase | None | ATP:tau-protein O-hosphotransferase; brain protein kinase PK40erk; cdk5/p20; CDK5/p23; glycogen synthase kinase-3beta; GSK; protein tau kinase; STK31; tau kinase; [tau-protein] kinase; tau-protein kinase I; tau-protein kinase II; tau-tubulin kinase; TPK; TPK I; TPK II; TTK | |
| 2.7.11.28 | tropomyosin kinase | False | 0 | 1 | 0 | 4 | ATP + tropomyosin = ADP + O-phosphotropomyosin | ATP:tropomyosin O-phosphotransferase | None | tropomyosin kinase (phosphorylating); STK (ambiguous) | |
| 2.7.11.29 | low-density-lipoprotein receptor kinase | True | 0 | 0 | 0 | 1 | ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine | ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase | None | ATP:low-density-lipoprotein-L-serine O-phosphotransferase; LDL receptor kinase; [low-density-lipoprotein] kinase; low-density lipoprotein kinase; low-density-lipoprotein receptor kinase (phosphorylating); STK7 | |
| 2.7.11.30 | receptor protein serine/threonine kinase | False | 54 | 20066 | 153 | 8 | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate | ATP:[receptor-protein] phosphotransferase | None | activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-beta kinase; receptor serine/threonine protein kinase | |
| 2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase | False | 10 | 1990 | 0 | 25 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase | None | AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; beta-hydroxy-beta-methylglutaryl-CoA reductase kinase; [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase; 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase; 3-hydroxy-3-methylglutaryl-CoA reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating); hydroxymethylglutaryl-CoA reductase kinase; reductase kinase; STK29 | |
| 2.7.13.1 | protein-histidine pros-kinase | False | 0 | 17 | 1 | 5 | ATP + protein L-histidine = ADP + protein Npi-phospho-L-histidine | ATP:protein-L-histidine Npi-phosphotransferase | None | ATP:protein-L-histidine N-pros-phosphotransferase; histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK2 | |
| 2.7.13.2 | protein-histidine tele-kinase | True | 0 | 0 | 0 | 1 | ATP + protein L-histidine = ADP + protein Ntau-phospho-L-histidine | ATP:protein-L-histidine Ntau-phosphotransferase | None | ATP:protein-L-histidine N-tele-phosphotransferase; histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK3 | |
| 2.7.13.3 | histidine kinase | False | 578 | 1276890 | 299 | 115 | ATP + protein L-histidine = ADP + protein N-phospho-L-histidine | ATP:protein-L-histidine N-phosphotransferase | None | EnvZ; histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK1; HP165; Sln1p | |
| 2.7.99.1 | triphosphate---protein phosphotransferase | False | 0 | 0 | 1 | 1 | triphosphate + [microsomal-membrane protein] = diphosphate + phospho-[microsomal-membrane protein] | triphosphate:[microsomal-membrane-protein] phosphotransferase | None | diphosphate:microsomal-membrane-protein O-phosphotransferase (erroneous); DiPPT (erroneous); pyrophosphate:protein phosphotransferase (erroneous); diphosphate---protein phosphotransferase (erroneous); diphosphate:[microsomal-membrane-protein] O-phosphotransferase (erroneous) | |
| 2.7.12.1 | dual-specificity kinase | False | 82 | 17376 | 249 | 50 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) | None | ADK1; Arabidopsis dual specificity kinase 1; CLK1; dDYRK2; Mps1p | |
| 2.7.12.2 | mitogen-activated protein kinase kinase | False | 73 | 20844 | 107 | 35 | ATP + a protein = ADP + a phosphoprotein | ATP:protein phosphotransferase (MAPKKK-activated) | None | MAP kinase kinase; MAP kinase kinase 4; MAP kinase kinase 7; MAP kinase or ERK kinase; MAP2K; MAPKK; MAPKK1; MEK; MEK1; MEK2; MKK; MKK2; MKK4; MKK6; MKK7; STK27 | |
| 1.1.1.289 | sorbose reductase | False | 2 | 73 | 3 | 3 | D-glucitol + NADP+ = L-sorbose + NADPH + H+ | D-glucitol:NADP+ oxidoreductase | None | Sou1p | |
| 1.1.1.290 | 4-phosphoerythronate dehydrogenase | False | 154 | 6292 | 5 | 3 | 4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH + H+ | 4-phospho-D-erythronate:NAD+ 2-oxidoreductase | None | PdxB; PdxB 4PE dehydrogenase; 4-O-phosphoerythronate dehydrogenase; 4PE dehydrogenase; erythronate-4-phosphate dehydrogenase | |
| 1.2.1.71 | succinylglutamate-semialdehyde dehydrogenase | False | 134 | 5317 | 4 | 4 | N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+ | N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase | None | succinylglutamic semialdehyde dehydrogenase; N-succinylglutamate 5-semialdehyde dehydrogenase; SGSD; AruD; AstD | |
| 1.2.1.72 | erythrose-4-phosphate dehydrogenase | False | 92 | 2963 | 3 | 2 | D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH + 2 H+ | D-erythrose 4-phosphate:NAD+ oxidoreductase | None | erythrose 4-phosphate dehydrogenase; E4PDH; GapB; Epd dehydrogenase; E4P dehydrogenase | |
| 1.7.1.13 | preQ1 synthase | False | 417 | 20872 | 10 | 5 | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+ | 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase | None | YkvM; QueF; preQ0 reductase; preQ0 oxidoreductase; 7-cyano-7-deazaguanine reductase; queuine synthase (incorrect as queuine is not the product); queuine:NADP+ oxidoreductase (incorrect as queuine is not the product) | |
| 5.2.1.12 | zeta-carotene isomerase | False | 2 | 16 | 0 | 2 | 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene | 9,15,9'-tricis-zeta-carotene cis-trans-isomerase | None | Z-ISO; 15-cis-zeta-carotene isomerase | |
| 1.11.1.16 | versatile peroxidase | False | 4 | 24 | 25 | 11 | (1) 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 4-hydroxy-3-methoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H2O;;(2) 2 manganese(II) + 2 H+ + H2O2 = 2 manganese(III) + 2 H2O | 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol:hydrogen-peroxide oxidoreductase | None | VP; hybrid peroxidase; polyvalent peroxidase; reactive-black-5:hydrogen-peroxide oxidoreductase | |
| 1.13.11.52 | indoleamine 2,3-dioxygenase | False | 8 | 5205 | 69 | 47 | (1) D-tryptophan + O2 = N-formyl-D-kynurenine;;(2) L-tryptophan + O2 = N-formyl-L-kynurenine | D-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) | None | IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) | False | 158 | 8220 | 0 | 9 | 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + formate + CO | 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) | None | ARD; 2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous); acireductone dioxygenase (ambiguous); E-2; 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) | |
| 1.13.11.54 | acireductone dioxygenase [iron(II)-requiring] | False | 158 | 9362 | 10 | 7 | 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-(methylsulfanyl)-2-oxobutanoate + formate | 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) | None | ARD'; 2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous); acireductone dioxygenase (ambiguous); E-2'; E-3 dioxygenase; 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) | |
| 1.13.11.55 | sulfur oxygenase/reductase | False | 1 | 5 | 14 | 12 | 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 sulfite | sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) | None | SOR; sulfur oxygenase; sulfur oxygenase reductase | |
| 1.14.13.101 | senecionine N-oxygenase | False | 1 | 2 | 0 | 10 | senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O | senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) | None | senecionine monooxygenase (N-oxide-forming); SNO | |
| 1.17.99.4 | uracil/thymine dehydrogenase | True | 0 | 0 | 0 | 5 | (1) uracil + H2O + acceptor = barbiturate + reduced acceptor;;(2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor | uracil:acceptor oxidoreductase | None | uracil oxidase; uracil-thymine oxidase; uracil dehydrogenase | |
| 2.3.1.177 | 3,5-dihydroxybiphenyl synthase | False | 1 | 10 | 2 | 12 | 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 | malonyl-CoA:benzoyl-CoA malonyltransferase | None | BIS1; biphenyl synthase (ambiguous) | |
| 2.3.1.178 | diaminobutyrate acetyltransferase | False | 18 | 4311 | 6 | 12 | acetyl-CoA + L-2,4-diaminobutanoate = CoA + (2S)-4-acetamido-2-aminobutanoate | acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase | None | L-2,4-diaminobutyrate acetyltransferase; L-2,4-diaminobutanoate acetyltransferase; EctA; diaminobutyric acid acetyltransferase; DABA acetyltransferase; 2,4-diaminobutanoate acetyltransferase; DAB acetyltransferase; DABAcT; acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase | |
| 2.3.1.179 | beta-ketoacyl-[acyl-carrier-protein] synthase II | False | 17 | 45657 | 92 | 27 | a (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadec-11-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | (Z)-hexadec-9-enoyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating) | None | KASII; KAS II; FabF; 3-oxoacyl-acyl carrier protein synthase II; beta-ketoacyl-ACP synthase II | |
| 2.3.1.180 | beta-ketoacyl-[acyl-carrier-protein] synthase III | False | 410 | 42771 | 38 | 62 | acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | acetyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase | None | 3-oxoacyl:ACP synthase III; 3-ketoacyl-acyl carrier protein synthase III; KASIII; KAS III; FabH; beta-ketoacyl-acyl carrier protein synthase III; beta-ketoacyl-ACP synthase III; beta-ketoacyl (acyl carrier protein) synthase III; acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase | |
| 2.3.1.300 | branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase | False | 8 | 0 | 0 | 7 | (1) 3-methylbutanoyl-CoA + a malonyl-[acyl-carrier protein] = a 5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2;;(2) 2-methylpropanoyl-CoA + a malonyl-[acyl-carrier protein] = a 4-methyl-3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2;;(3) (2S)-2-methylbutanoyl-CoA + a malonyl-[acyl-carrier protein] = a (4S)-4-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2 | 3-methylbutanoyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase | None | None | |
| 2.3.1.181 | lipoyl(octanoyl) transferase | False | 463 | 33973 | 0 | 11 | an octanoyl-[acyl-carrier protein] + a protein = a protein N6-(octanoyl)lysine + an [acyl-carrier protein] | octanoyl-[acyl-carrier protein]:protein N-octanoyltransferase | None | LipB; lipoyl (octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase; lipoyl (octanoyl)-acyl carrier protein:protein transferase; lipoate/octanoate transferase; lipoyltransferase; octanoyl-[acyl carrier protein]-protein N-octanoyltransferase; lipoyl(octanoyl)transferase; octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase | |
| 2.4.1.244 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase | False | 4 | 1771 | 0 | 3 | UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group | UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase | None | beta1,4-N-acetylgalactosaminyltransferase III; beta4GalNAc-T3; beta1,4-N-acetylgalactosaminyltransferase IV; beta4GalNAc-T4; UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase | |
| 2.6.1.81 | succinylornithine transaminase | False | 47 | 923 | 1 | 12 | N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate | N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase | None | succinylornithine aminotransferase; N2-succinylornithine 5-aminotransferase; AstC; SOAT; 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase | |
| 2.6.99.2 | pyridoxine 5'-phosphate synthase | False | 259 | 22608 | 7 | 7 | 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O | 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) | None | pyridoxine 5-phosphate phospho lyase; PNP synthase; PdxJ | |
| 2.7.1.158 | inositol-pentakisphosphate 2-kinase | False | 19 | 4342 | 22 | 11 | ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate | ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase | None | IP5 2-kinase; Gsl1p; Ipk1p; inositol polyphosphate kinase; inositol 1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase | |
| 2.7.1.159 | inositol-1,3,4-trisphosphate 5/6-kinase | False | 28 | 2101 | 1 | 9 | (1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate;;(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase | None | Ins(1,3,4)P3 5/6-kinase; inositol trisphosphate 5/6-kinase | |
| 2.7.4.22 | UMP kinase | False | 554 | 46474 | 14 | 16 | ATP + UMP = ADP + UDP | ATP:UMP phosphotransferase | None | uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA | |
| 2.7.7.90 | 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase | False | 19 | 75 | 0 | 1 | CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate | CTP:8-amino-3,8-dideoxy-alpha-D-manno-octulosonate cytidylyltransferase | None | kdsB (gene name, ambiguous) | |
| 2.4.1.243 | 6G-fructosyltransferase | False | 2 | 2 | 0 | 5 | [1-beta-D-fructofuranosyl-(2->1)-]m+1-alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n-alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m-alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n-beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0) | 1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase | None | fructan:fructan 6G-fructosyltransferase; 1F(1-beta-D-fructofuranosyl)m sucrose:1F(1-beta-D-fructofuranosyl)nsucrose 6G-fructosyltransferase; 6G-FFT; 6G-FT; 6G-fructotransferase | |
| 2.8.1.8 | lipoyl synthase | False | 646 | 39227 | 5 | 11 | [protein]-N6-(octanoyl)-L-lysine + an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-adenosyl-L-methionine + 2 oxidized [2Fe-2S] ferredoxin + 6 H+ = [protein]-N6-[(R)-dihydrolipoyl]-L-lysine + an [Fe-S] cluster scaffold protein + 2 sulfide + 4 Fe3+ + 2 L-methionine + 2 5'-deoxyadenosine + 2 reduced [2Fe-2S] ferredoxin | [protein]-N6-(octanoyl)-L-lysine:an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase | None | lipA (gene name); LS; lipoate synthase; protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase; protein N6-(octanoyl)lysine:sulfur sulfurtransferase; protein N6-(octanoyl)lysine:sulfur-(sulfur carrier) sulfurtransferase | |
| 3.1.3.76 | lipid-phosphate phosphatase | False | 4 | 12 | 0 | 3 | (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate | (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate phosphohydrolase | None | hydroxy fatty acid phosphatase; dihydroxy fatty acid phosphatase; hydroxy lipid phosphatase; sEH (ambiguous); soluble epoxide hydrolase (ambiguous); (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase | |
| 3.1.13.5 | ribonuclease D | False | 20 | 10999 | 3 | 2 | Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides | None | None | RNase D | |
| 3.2.1.155 | xyloglucan-specific endo-processive beta-1,4-glucanase | False | 1 | 15 | 0 | 5 | Hydrolysis of (1->4)-D-glucosidic linkages in xyloglucans so as to successively remove oligosaccharides from the newly-formed chain end after endo-initiation on a polymer molecule | [(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan endo-processive glucohydrolase | None | Cel74A; [(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase (ambiguous); xyloglucan-specific exo-beta-1,4-glucanase (ambiguous) | |
| 3.2.1.157 | iota-carrageenase | False | 2 | 34 | 3 | 9 | Endohydrolysis of (1->4)-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans | iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) | None | None | |
| 3.2.1.158 | alpha-agarase | False | 2 | 117 | 0 | 4 | Endohydrolysis of (1->3)-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product | agarose 3-glycanohydrolase | None | agarase (ambiguous); agaraseA33 | |
| 3.2.1.159 | alpha-neoagaro-oligosaccharide hydrolase | False | 0 | 3 | 1 | 2 | Hydrolysis of the (1->3)-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose | alpha-neoagaro-oligosaccharide 3-glycohydrolase | None | alpha-neoagarooligosaccharide hydrolase; alpha-NAOS hydrolase | |
| 3.2.1.161 | beta-apiosyl-beta-glucosidase | False | 2 | 5 | 0 | 3 | 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose | 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase | None | isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase; isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase; furcatin hydrolase | |
| 3.3.2.9 | microsomal epoxide hydrolase | False | 9 | 3460 | 6 | 38 | (1) cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol;;(2) 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol | cis-stilbene-oxide hydrolase | None | microsomal oxirane/oxetane hydrolase; epoxide hydratase (ambiguous); microsomal epoxide hydratase (ambiguous); epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo(a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH; EPHX1 (gene name) | |
| 3.3.2.10 | soluble epoxide hydrolase | False | 49 | 2410 | 109 | 46 | an epoxide + H2O = a glycol | epoxide hydrolase | None | epoxide hydrase (ambiguous); epoxide hydratase (ambiguous); arene-oxide hydratase (ambiguous); aryl epoxide hydrase (ambiguous); trans-stilbene oxide hydrolase; sEH; cytosolic epoxide hydrolase | |
| 3.3.2.11 | cholesterol-5,6-oxide hydrolase | False | 1 | 3 | 0 | 5 | (1) 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5alpha,6beta-triol;;(2) 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5alpha,6beta-triol | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase | None | cholesterol-epoxide hydrolase; ChEH | |
| 3.4.23.49 | omptin | False | 2 | 237 | 1 | 8 | Has a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1' position, which can also contain Lys, Gly or Val. | None | None | protease VII; protease A; gene ompT proteins; ompT protease; protein a; Pla; OmpT | |
| 3.5.1.94 | gamma-glutamyl-gamma-aminobutyrate hydrolase | False | 4 | 856 | 1 | 1 | 4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate | 4-(gamma-L-glutamylamino)butanoate amidohydrolase | None | gamma-glutamyl-GABA hydrolase; PuuD; YcjL; 4-(gamma-glutamylamino)butanoate amidohydrolase; 4-(L-gamma-glutamylamino)butanoate amidohydrolase | |
| 3.5.1.95 | N-malonylurea hydrolase | True | 0 | 0 | 0 | 1 | 3-oxo-3-ureidopropanoate + H2O = malonate + urea | 3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) | None | ureidomalonase | |
| 3.5.1.96 | succinylglutamate desuccinylase | False | 115 | 4367 | 0 | 3 | N-succinyl-L-glutamate + H2O = succinate + L-glutamate | N-succinyl-L-glutamate amidohydrolase | None | N2-succinylglutamate desuccinylase; SGDS; AstE | |
| 3.5.3.23 | N-succinylarginine dihydrolase | False | 138 | 5464 | 0 | 3 | N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO2 | N2-succinyl-L-arginine iminohydrolase (decarboxylating) | None | N2-succinylarginine dihydrolase; arginine succinylhydrolase; SADH; AruB; AstB; 2-N-succinyl-L-arginine iminohydrolase (decarboxylating) | |
| 4.1.1.86 | diaminobutyrate decarboxylase | False | 3 | 1088 | 5 | 16 | L-2,4-diaminobutanoate = propane-1,3-diamine + CO2 | L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) | None | DABA DC; L-2,4-diaminobutyrate decarboxylase; L-2,4-diaminobutanoate carboxy-lyase | |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate aldolase | False | 174 | 6979 | 4 | 5 | (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate | (S)-4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) | None | 4-hydroxy-2-ketovalerate aldolase; HOA; DmpG; 4-hydroxy-2-oxovalerate pyruvate-lyase; 4-hydroxy-2-oxopentanoate pyruvate-lyase; BphI; 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) | |
| 4.2.1.108 | ectoine synthase | False | 48 | 5374 | 5 | 18 | (2S)-4-acetamido-2-aminobutanoate = L-ectoine + H2O | (2S)-4-acetamido-2-aminobutanoate (L-ectoine-forming) | None | ectC (gene name); N-acetyldiaminobutyrate dehydratase; N-acetyldiaminobutanoate dehydratase; L-ectoine synthase; 4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming); N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) | |
| 4.2.1.171 | cis-L-3-hydroxyproline dehydratase | False | 5 | 6 | 0 | 5 | cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O | cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming) | None | cis-L-3-hydroxyproline hydro-lyase; c3LHypD | |
| 4.2.3.22 | germacradienol synthase | False | 2 | 14 | 2 | 4 | (2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] | None | germacradienol/germacrene-D synthase; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] | |
| 4.2.3.24 | amorpha-4,11-diene synthase | False | 1 | 2 | 2 | 1 | (2E,6E)-farnesyl diphosphate = amorpha-4,11-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) | None | amorphadiene synthase | |
| 4.2.3.25 | S-linalool synthase | False | 8 | 40 | 0 | 16 | geranyl diphosphate + H2O = (3S)-linalool + diphosphate | geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] | None | LIS; Lis; 3S-linalool synthase | |
| 4.2.3.26 | R-linalool synthase | False | 12 | 18 | 0 | 6 | geranyl diphosphate + H2O = (3R)-linalool + diphosphate | geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] | None | (3R)-linalool synthase; (-)-3R-linalool synthase | |
| 4.4.1.24 | (2R)-sulfolactate sulfo-lyase | False | 4 | 354 | 0 | 3 | (2R)-3-sulfolactate = pyruvate + hydrogensulfite | (2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming) | None | Suy; SuyAB; 3-sulfolactate bisulfite-lyase; sulfolactate sulfo-lyase (ambigious); (2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming) | |
| 4.4.1.25 | L-cysteate sulfo-lyase | False | 2 | 186 | 0 | 4 | L-cysteate + H2O = hydrogensulfite + pyruvate + NH3 (overall reaction);;(1a) L-cysteate = hydrogensulfite + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-cysteate hydrogensulfite-lyase (deaminating; pyruvate-forming) | None | L-cysteate sulfo-lyase (deaminating); CuyA; L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) | |
| 5.3.3.14 | trans-2-decenoyl-[acyl-carrier protein] isomerase | False | 193 | 6711 | 0 | 3 | a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein] | decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase | None | beta-hydroxydecanoyl thioester dehydrase; trans-2-cis-3-decenoyl-ACP isomerase; trans-2,cis-3-decenoyl-ACP isomerase; trans-2-decenoyl-ACP isomerase; FabM; decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase | |
| 5.4.99.18 | 5-(carboxyamino)imidazole ribonucleotide mutase | False | 25 | 38356 | 21 | 7 | 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate | 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase | None | N5-CAIR mutase; PurE; N5-carboxyaminoimidazole ribonucleotide mutase; class I PurE | |
| 6.3.4.18 | 5-(carboxyamino)imidazole ribonucleotide synthase | False | 29 | 26864 | 4 | 6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) | None | N5-CAIR synthetase; N5-carboxyaminoimidazole ribonucleotide synthetase; PurK | |
| 4.2.3.23 | germacrene-A synthase | False | 10 | 25 | 0 | 14 | (2E,6E)-farnesyl diphosphate = (+)-(R)-gemacrene A + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-(R)-germacrene-A-forming] | None | germacrene A synthase; (+)-germacrene A synthase; (+)-(10R)-germacrene A synthase; GAS; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) | |
| 1.8.4.11 | peptide-methionine (S)-S-oxide reductase | False | 327 | 63326 | 24 | 60 | (1) peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;; (2) L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin | peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] | None | MsrA; methionine sulfoxide reductase (ambiguous); methionine sulphoxide reductase A; methionine S-oxide reductase (ambiguous); methionine S-oxide reductase (S-form oxidizing); methionine sulfoxide reductase A; peptide methionine sulfoxide reductase | |
| 1.8.4.12 | peptide-methionine (R)-S-oxide reductase | False | 240 | 45571 | 10 | 54 | peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin | peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] | None | MsrB; methionine sulfoxide reductase (ambiguous); pMSR; methionine S-oxide reductase (ambiguous); selenoprotein R; methionine S-oxide reductase (R-form oxidizing); methionine sulfoxide reductase B; SelR; SelX; PilB; pRMsr | |
| 1.8.4.13 | L-methionine (S)-S-oxide reductase | False | 1 | 15 | 1 | 2 | L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin | L-methionine:thioredoxin-disulfide S-oxidoreductase | None | fSMsr; methyl sulfoxide reductase I and II; acetylmethionine sulfoxide reductase; methionine sulfoxide reductase; L-methionine:oxidized-thioredoxin S-oxidoreductase; methionine-S-oxide reductase; free-methionine (S)-S-oxide reductase | |
| 1.8.4.14 | L-methionine (R)-S-oxide reductase | False | 16 | 1218 | 7 | 3 | L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin | L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] | None | fRMsr; FRMsr; free met-R-(o) reductase; free-methionine (R)-S-oxide reductase | |
| 1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase | False | 54 | 3649 | 46 | 7 | a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6-methyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine36 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase | None | KDM2A (gene name); KDM2B (gene name); JHDM1A (gene name); JHDM1B (gene name); JmjC domain-containing histone demethylase 1A; H3-K36-specific demethylase (ambiguous); histone-lysine (H3-K36) demethylase (ambiguous); histone demethylase (ambiguous); protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase; protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase; [histone-H3]-lysine-36 demethylase | |
| 2.6.1.82 | putrescine---2-oxoglutarate transaminase | False | 47 | 1828 | 5 | 5 | putrescine + 2-oxoglutarate = 4-aminobutanal + L-glutamate | putrescine:2-oxoglutarate aminotransferase | None | putrescine-alpha-ketoglutarate transaminase; YgjG; putrescine:alpha-ketoglutarate aminotransferase; PAT (ambiguous); putrescine transaminase (ambiguous); putrescine aminotransferase (ambiguous); butane-1,4-diamine:2-oxoglutarate aminotransferase | |
| 2.6.1.83 | LL-diaminopimelate aminotransferase | False | 102 | 8078 | 13 | 19 | LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O | LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase | None | LL-diaminopimelate transaminase; LL-DAP aminotransferase; LL-DAP-AT | |
| 2.7.1.160 | 2'-phosphotransferase | False | 6 | 3892 | 5 | 35 | 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase | None | yeast 2'-phosphotransferase; Tpt1; Tpt1p; 2'-phospho-tRNA:NAD+ phosphotransferase | |
| 2.7.4.23 | ribose 1,5-bisphosphate phosphokinase | False | 40 | 4525 | 0 | 1 | ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate | ATP:alpha-D-ribose-1,5-bisphosphate phosphotransferase | None | ribose 1,5-bisphosphokinase; PhnN; ATP:ribose-1,5-bisphosphate phosphotransferase | |
| 3.1.1.80 | acetylajmaline esterase | False | 2 | 6 | 0 | 2 | (1) 17-O-acetylajmaline + H2O = ajmaline + acetate;;(2) 17-O-acetylnorajmaline + H2O = norajmaline + acetate | 17-O-acetylajmaline O-acetylhydrolase | None | AAE; 2beta(R)-17-O-acetylajmalan:acetylesterase; acetylajmalan esterase | |
| 3.1.3.77 | acireductone synthase | False | 171 | 4851 | 0 | 5 | 5-(methylsulfanyl)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate (overall reaction);;(1a) 5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate (probably spontaneous);;(1b) 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate | 5-(methylsulfanyl)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) | None | E1; E-1 enolase-phosphatase; 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) | |
| 4.2.1.109 | methylthioribulose 1-phosphate dehydratase | False | 195 | 7894 | 1 | 6 | 5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-(methylsulfanyl)-2,3-dioxopentyl phosphate + H2O | 5-(methylsulfanyl)-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylsulfanyl)-2,3-dioxopentyl-phosphate-forming] | None | 1-PMT-ribulose dehydratase; S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase; S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming] | |
| 4.2.2.20 | chondroitin-sulfate-ABC endolyase | False | 2 | 75 | 5 | 4 | Endolytic cleavage of (1->4)-beta-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides | chondroitin-sulfate-ABC endolyase | None | chondroitinase (ambiguous); chondroitin ABC eliminase (ambiguous); chondroitinase ABC (ambiguous); chondroitin ABC lyase (ambiguous); chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I | |
| 4.2.2.21 | chondroitin-sulfate-ABC exolyase | False | 3 | 35 | 1 | 6 | Exolytic removal of Delta4-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments. | chondroitin-sulfate-ABC exolyase | None | chondroitinase (ambiguous); chondroitin ABC eliminase (ambiguous); chondroitinase ABC (ambiguous); chondroitin ABC lyase (ambiguous); chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); chondroitin sulfate ABC exoeliminase; chondroitin sulfate ABC exolyase; ChS ABC lyase II | |
| 4.2.99.21 | isochorismate lyase | False | 5 | 291 | 0 | 7 | isochorismate = salicylate + pyruvate | isochorismate pyruvate-lyase (salicylate-forming) | None | salicylate biosynthesis protein pchB; pyochelin biosynthetic protein PchB; isochorismate pyruvate lyase | |
| 4.1.2.8 | indole-3-glycerol-phosphate lyase | False | 3 | 1 | 0 | 6 | (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate | (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) | None | tryptophan synthase alpha; TSA; indoleglycerolphosphate aldolase; indole glycerol phosphate hydrolase; indole synthase; indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase; indole-3-glycerol phosphate lyase; IGL; BX1; (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase | |
| 1.14.11.28 | proline 3-hydroxylase | False | 2 | 6 | 0 | 5 | L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2 | L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | P-3-H | |
| 3.4.14.12 | Xaa-Xaa-Pro tripeptidyl-peptidase | False | 2 | 1344 | 0 | 3 | Hydrolysis of Xaa-Xaa-Pro!Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline | None | None | prolyltripeptidyl amino peptidase; prolyl tripeptidyl peptidase; prolyltripeptidyl aminopeptidase; PTP-A; TPP | |
| 3.4.21.106 | hepsin | False | 4 | 5 | 2 | 6 | Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys | None | None | None | |
| 3.4.21.107 | peptidase Do | False | 38 | 22968 | 33 | 36 | Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val!Val | None | None | DegP; DegP protease; HtrA; high temperature requirement protease A; HrtA heat shock protein; protease Do; Do protease | |
| 3.4.21.108 | HtrA2 peptidase | False | 15 | 787 | 11 | 19 | Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues | None | None | high temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; serine proteinase OMI; HtrA2 protease; OMI/HtrA2 protease; HtrA2/Omi; Omi/HtrA2 | |
| 3.4.21.109 | matriptase | False | 3 | 371 | 21 | 9 | Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position | None | None | serine protease 14; membrane-type serine protease 1; MT-SP1; prostamin; serine protease TADG-15; tumor-associated differentially-expressed gene 15 protein; ST14; breast cancer 80 kDa protease; epithin; serine endopeptidase SNC19; matriptase-1; matriptase-2; matriptase-3; TMPRSS6 (gene name) | |
| 3.4.21.110 | C5a peptidase | False | 6 | 3517 | 4 | 5 | The primary cleavage site is at His67!Lys68 in human C5a with a minor secondary cleavage site at Ala58!Ser59 | None | None | streptococcal C5a peptidase; ScpA; ScpB; SCPA | |
| 3.4.21.111 | aqualysin 1 | False | 1 | 85 | 1 | 2 | Exhibits low specificity towards esters of amino acids with small hydrophobic or aromatic residues at the P1 position | None | None | caldolysin | |
| 3.4.21.112 | site-1 protease | False | 4 | 37 | 1 | 9 | Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3 | None | None | mammalian subtilisin/kexin isozyme 1; membrane-bound transcription factor site-1 protease; proprotein convertase SKI-1; proprotein convertase SKI-1/S1PPS1; S1P endopeptidase; S1P protease; site-1 peptidase; site-1 protease; SKI-1; SREBP proteinase; SREBP S1 protease; SREBP-1 proteinase; SREBP-2 proteinase; sterol regulatory element-binding protein proteinase; sterol regulatory element-binding protein site 1 protease; sterol-regulated luminal protease; subtilase SKI-1; subtilase SKI-1/S1P; subtilisin/kexin-isozyme 1 | |
| 3.4.21.114 | equine arterivirus serine peptidase | False | 0 | 0 | 2 | 2 | Cleavage of (Glu/Gln)!(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab | None | None | None | |
| 3.4.21.115 | infectious pancreatic necrosis birnavirus Vp4 peptidase | False | 0 | 0 | 3 | 6 | Cleaves the (Ser/Thr)-Xaa-Ala!(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions | None | None | infectious pancreatic necrosis virus protease; IPNV Vp4 protease; IPNV Vp4 peptidase; NS protease; NS-associated protease; Vp4 protease | |
| 3.4.21.116 | SpoIVB peptidase | False | 1 | 2051 | 0 | 1 | Self-cleaves Val52!Asn53, Ala62!Phe63 and Val74!Thr75 at the N-terminus of SpoIVB | None | None | sporulation factor IV B protease | |
| 3.4.21.117 | stratum corneum chymotryptic enzyme | False | 2 | 0 | 15 | 4 | Cleavage of proteins with aromatic side chains in the P1 position | None | None | kallikrein 7; SCCE; KLK7; PRSS6; hK7 | |
| 3.4.21.118 | kallikrein 8 | False | 3 | 0 | 2 | 5 | Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys | None | None | KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin | |
| 3.4.21.119 | kallikrein 13 | False | 1 | 1 | 0 | 2 | Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin | None | None | KLK13; kallikrein mK13; mGK-13; mK13; mKLK13; prorenin converting enzyme 1; PRECE-1; prorenin-converting enzyme; PRECE; proteinase P | |
| 1.4.3.20 | L-lysine 6-oxidase | False | 1 | 66 | 3 | 4 | L-lysine + O2 + H2O = (S)-2-amino-6-oxohexanoate + H2O2 + NH3 | L-lysine:oxygen 6-oxidoreductase (deaminating) | None | L-lysine-epsilon-oxidase; Lod; LodA; marinocine | |
| 3.4.21.113 | pestivirus NS3 polyprotein peptidase | False | 5 | 136 | 5 | 4 | Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites | None | None | border disease virus NS3 endopeptidase; BDV NS3 endopeptidase; bovine viral diarrhea virus NS3 endopeptidase; BVDV NS3 endopeptidase; classical swine fever virus NS3 endopeptidase; CSFV NS3 endopeptidase; p80 | |
| 1.1.1.291 | 2-hydroxymethylglutarate dehydrogenase | False | 1 | 535 | 1 | 1 | (S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ | (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase | None | HgD | |
| 1.1.99.31 | (S)-mandelate dehydrogenase | False | 2 | 363 | 2 | 5 | (S)-mandelate + acceptor = phenylglyoxylate + reduced acceptor | (S)-mandelate:acceptor 2-oxidoreductase | None | MDH (ambiguous) | |
| 1.3.3.12 | L-galactonolactone oxidase | False | 1 | 2 | 0 | 3 | L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 | L-galactono-1,4-lactone:oxygen 3-oxidoreductase | None | L-galactono-1,4-lactone oxidase | |
| 2.7.7.64 | UTP-monosaccharide-1-phosphate uridylyltransferase | False | 6 | 997 | 6 | 11 | UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide | None | None | UDP-sugar pyrophosphorylase; PsUSP | |
| 2.7.8.27 | sphingomyelin synthase | False | 17 | 823 | 4 | 12 | a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol | ceramide:phosphatidylcholine cholinephosphotransferase | None | SM synthase; SMS1; SMS2 | |
| 3.4.13.22 | D-Ala-D-Ala dipeptidase | False | 5 | 12117 | 1 | 8 | D-Ala-D-Ala + H2O = 2 D-Ala | None | None | D-alanyl-D-alanine dipeptidase; vanX D-Ala-D-Ala dipeptidase; VanX | |
| 3.5.2.18 | enamidase | False | 1 | 155 | 1 | 1 | 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH3 | 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase | None | None | |
| 4.2.1.110 | aldos-2-ulose dehydratase | False | 1 | 1 | 3 | 8 | 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction);;(1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O;;(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one | 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) | None | pyranosone dehydratase; AUDH; 1,5-anhydro-D-fructose dehydratase (microthecin-forming) | |
| 4.2.1.111 | 1,5-anhydro-D-fructose dehydratase | True | 0 | 0 | 0 | 4 | 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O | 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) | None | 1,5-anhydro-D-fructose 4-dehydratase; 1,5-anhydro-D-fructose hydrolyase; 1,5-anhydro-D-arabino-hex-2-ulose dehydratase; AFDH; AF dehydratase; 1,5-anhydro-D-fructose hydro-lyase | |
| 6.3.1.12 | D-aspartate ligase | False | 1 | 151 | 0 | 4 | ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate | D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) | None | Aslfm; UDP-MurNAc-pentapeptide:D-aspartate ligase; D-aspartic acid-activating enzyme | |
| 6.4.1.7 | 2-oxoglutarate carboxylase | False | 2 | 617 | 3 | 2 | ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate | None | None | oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC | |
| 3.4.22.55 | caspase-2 | False | 4 | 35 | 9 | 6 | Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp! | None | None | ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein | |
| 3.4.22.56 | caspase-3 | False | 13 | 1238 | 96 | 15 | Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp! with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position | None | None | CPP32; apopain; yama protein | |
| 3.4.22.57 | caspase-4 | False | 2 | 1 | 8 | 3 | Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp! but also cleaves at Asp-Glu-Val-Asp! | None | None | ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4 | |
| 3.4.22.58 | caspase-5 | False | 2 | 0 | 0 | 2 | Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp! but also cleaves at Asp-Glu-Val-Asp! | None | None | ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5 | |
| 3.4.22.59 | caspase-6 | False | 5 | 947 | 35 | 8 | Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp! | None | None | CASP-6; apoptotic protease Mch-2; Mch2 | |
| 3.4.22.60 | caspase-7 | False | 6 | 70 | 39 | 7 | Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp! | None | None | CASP-7; ICE-like apoptotic protease 3; ICE-LAP3; apoptotic protease Mch-3; Mch3; CMH-1 | |
| 3.4.22.61 | caspase-8 | False | 5 | 54 | 20 | 17 | Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp!(Gly/Ser/Ala) | None | None | FLICE; FADD-like ICE; MACH; MORT1-associated CED-3 homolog; Mch5; mammalian Ced-3 homolog 5; CASP-8; ICE-like apoptotic protease 5; FADD-homologous ICE/CED-3-like protease; apoptotic cysteine protease; apoptotic protease Mch-5; CAP4 | |
| 3.4.22.62 | caspase-9 | False | 2 | 11 | 4 | 10 | Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp!Xaa | None | None | CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3 | |
| 3.4.22.63 | caspase-10 | False | 1 | 2 | 0 | 6 | Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly | None | None | FLICE2; Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1beta-converting enzyme 2 | |
| 3.4.22.64 | caspase-11 | False | 1 | 1 | 5 | 3 | Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp! | None | None | CASP-11 | |
| 1.1.1.292 | 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) | False | 2 | 2229 | 1 | 4 | 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ | 1,5-anhydro-D-mannitol:NADP+ oxidoreductase | None | 1,5-anhydro-D-fructose reductase (ambiguous); AFR (ambiguous) | |
| 3.2.1.162 | lambda-carrageenase | False | 2 | 19 | 0 | 4 | Endohydrolysis of (1->4)-beta-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Gal<em>p</em>2,6S<small><sub>2</sub></small>-(1->3)-beta-D-Gal<em>p</em>2S-(1->4)-alpha-D-Gal<em>p</em>2,6S<small><sub>2</sub></small>-(1->3)-D-Gal<em>p</em>2<em>S</em> | endo-(1->4)-beta-carrageenose 2,6,2'-trisulfate-hydrolase | None | endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase | |
| 3.4.21.120 | oviductin | False | 3 | 11 | 0 | 14 | Preferential cleavage at Gly-Ser-Arg373! of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41 | None | None | oviductal protease | |
| 3.4.22.54 | calpain-3 | False | 8 | 1947 | 5 | 9 | Broad endopeptidase activity | None | None | p94; calpain p94; CAPN3; muscle calpain; calpain 3; calcium-activated neutral proteinase 3; muscle-specific calcium-activated neutral protease 3; CANP 3; calpain L3 | |
| 3.11.1.3 | phosphonopyruvate hydrolase | False | 1 | 116 | 0 | 2 | 3-phosphonopyruvate + H2O = pyruvate + phosphate | None | None | PPH | |
| 4.1.3.40 | chorismate lyase | False | 148 | 6042 | 2 | 6 | chorismate = 4-hydroxybenzoate + pyruvate | chorismate pyruvate-lyase (4-hydroxybenzoate-forming) | None | CL; CPL; UbiC | |
| 2.5.1.67 | chrysanthemyl diphosphate synthase | False | 2 | 2 | 1 | 2 | 2 prenyl diphosphate = diphosphate + chrysanthemyl diphosphate | prenyl-diphosphate:prenyl-diphosphate prenyltransferase (chrysanthemyl-diphosphate-forming) | None | CPPase; dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) | |
| 2.5.1.68 | (2Z,6E)-farnesyl diphosphate synthase | False | 7 | 118 | 3 | 7 | geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate | geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase | None | (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase | |
| 2.5.1.69 | lavandulyl diphosphate synthase | False | 1 | 1 | 0 | 4 | 2 prenyl diphosphate = diphosphate + lavandulyl diphosphate | prenyl-diphosphate:prenyl-diphosphate prenyltransferase (lavandulyl-diphosphate-forming) | None | FDS-5; dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) | |
| 3.2.2.25 | N-methyl nucleosidase | True | 0 | 0 | 0 | 3 | 7-methylxanthosine + H2O = 7-methylxanthine + D-ribose | 7-methylxanthosine ribohydrolase | None | 7-methylxanthosine nucleosidase; N-MeNase; N-methyl nucleoside hydrolase; methylpurine nucleosidase | |
| 4.2.1.112 | acetylene hydratase | False | 1 | 149 | 0 | 9 | acetaldehyde = acetylene + H2O | acetaldehyde hydro-lyase (acetylene-forming) | None | AH; acetaldehyde hydro-lyase | |
| 4.2.3.27 | isoprene synthase | False | 4 | 16 | 2 | 19 | prenyl diphosphate = isoprene + diphosphate | prenyl-diphosphate diphosphate-lyase (isoprene-forming) | None | ISPC; ISPS; dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) | |
| 2.1.1.158 | 7-methylxanthosine synthase | False | 3 | 4 | 0 | 4 | S-adenosyl-L-methionine + xanthosine = S-adenosyl-L-homocysteine + 7-methylxanthosine | S-adenosyl-L-methionine:xanthosine N7-methyltransferase | None | xanthosine methyltransferase; XMT; xanthosine:S-adenosyl-L-methionine methyltransferase; CtCS1; CmXRS1; CaXMT1; S-adenosyl-L-methionine:xanthosine 7-N-methyltransferase | |
| 2.1.1.159 | theobromine synthase | False | 13 | 77 | 0 | 11 | S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine | S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase | None | monomethylxanthine methyltransferase; MXMT; CTS1; CTS2; S-adenosyl-L-methionine:7-methylxanthine 3-N-methyltransferase | |
| 2.1.1.160 | caffeine synthase | False | 9 | 5 | 0 | 9 | (1) S-adenosyl-L-methionine + 3,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine;;(2) S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine;;(3) S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine | S-adenosyl-L-methionine:3,7-dimethylxanthine N1-methyltransferase | None | dimethylxanthine methyltransferase; 3N-methyltransferase; DXMT; CCS1; S-adenosyl-L-methionine:3,7-dimethylxanthine 1-N-methyltransferase | |
| 2.5.1.70 | naringenin 8-dimethylallyltransferase | False | 2 | 1 | 0 | 1 | prenyl diphosphate + (-)-(2S)-naringenin = diphosphate + sophoraflavanone B | prenyl-diphosphate:naringenin 8-prenyltransferase | None | N8DT; dimethylallyl-diphosphate:naringenin 8-dimethylallyltransferase | |
| 2.5.1.71 | leachianone-G 2''-dimethylallyltransferase | True | 0 | 0 | 0 | 1 | prenyl diphosphate + leachianone G = diphosphate + sophoraflavanone G | prenyl-diphosphate:leachianone-G 2''-prenyltransferase | None | LG 2''-dimethylallyltransferase; leachianone G 2''-dimethylallyltransferase; LGDT; dimethylallyl-diphosphate:leachianone-G 2''-dimethylallyltransferase | |
| 2.7.4.24 | diphosphoinositol-pentakisphosphate 1-kinase | False | 15 | 10218 | 15 | 5 | (1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate;; (2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate | ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate 1-phosphotransferase | None | PP-IP5 kinase; diphosphoinositol pentakisphosphate kinase; ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase; PP-InsP5 kinase; PPIP5K; PPIP5K1; PPIP5K2; VIP1; VIP2; diphosphoinositol-pentakisphosphate 1/3-kinase (incorrect); diphosphoinositol-pentakisphosphate kinase (ambiguous) | |
| 2.8.2.36 | desulfo-A47934 sulfotransferase | False | 1 | 7 | 0 | 1 | 3'-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3',5'-bisphosphate + A47934 | 3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfonotransferase | None | StaL; 3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase | |
| 3.2.1.163 | 1,6-alpha-D-mannosidase | False | 0 | 1 | 0 | 6 | Hydrolysis of the (1->6)-linked alpha-D-mannose residues in alpha-D-Manp-(1->6)-D-Manp | (1->6)-alpha-mannosyl alpha-D-mannohydrolase | None | None | |
| 2.6.1.84 | arginine---pyruvate transaminase | False | 1 | 46 | 0 | 1 | L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine | L-arginine:pyruvate aminotransferase | None | arginine:pyruvate transaminase; AruH; ATase | |
| 3.4.22.65 | peptidase 1 (mite) | False | 5 | 7 | 1 | 2 | Broad endopeptidase specificity | None | None | allergen Der f 1; allergen Der p 1; antigen Der p 1; antigen Eur m 1; antigen Pso o 1; major mite fecal allergen Der p 1; Der p 1; Der f 1; Eur m 1; endopeptidase 1 (mite) | |
| 2.6.1.85 | aminodeoxychorismate synthase | False | 20 | 20780 | 6 | 8 | chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) chorismate + NH3 = 4-amino-4-deoxychorismate + H2O | chorismate:L-glutamine aminotransferase | None | ADC synthase; 4-amino-4-deoxychorismate synthase; PabAB; chorismate:L-glutamine amido-ligase (incorrect) | |
| 3.2.1.164 | galactan endo-1,6-beta-galactosidase | False | 1 | 22 | 0 | 5 | Endohydrolysis of (1->6)-beta-D-galactosidic linkages in arabinogalactan proteins and (1->3):(1->6)-beta-galactans to yield galactose and (1->6)-beta-galactobiose as the final products | endo-beta-(1->6)-galactanase | None | endo-1,6-beta-galactanase | |
| 3.4.15.6 | cyanophycinase | False | 7 | 5926 | 3 | 32 | [L-Asp(4-L-Arg)]n + H2O = [L-Asp(4-L-Arg)]n-1 + L-Asp(4-L-Arg) | None | None | cyanophycin degrading enzyme; beta-Asp-Arg hydrolysing enzyme; CGPase; CphB; CphE; cyanophycin granule polypeptidase; extracellular CGPase | |
| 3.4.22.67 | zingipain | False | 2 | 15 | 0 | 2 | Preferential cleavage of peptides with a proline residue at the P2 position | None | None | ginger protease; GP-I; GP-II; ginger protease II (Zingiber officinale); zingibain | |
| 4.1.99.12 | 3,4-dihydroxy-2-butanone-4-phosphate synthase | False | 246 | 40957 | 23 | 15 | D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate | D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming) | None | DHBP synthase; L-3,4-dihydroxybutan-2-one-4-phosphate synthase | |
| 6.1.1.26 | pyrrolysine---tRNAPyl ligase | False | 6 | 97 | 59 | 8 | ATP + L-pyrrolysine + tRNAPyl = AMP + diphosphate + L-pyrrolysyl-tRNAPyl | L-pyrrolysine:tRNAPyl ligase (AMP-forming) | None | PylS; pyrrolysyl-tRNA synthetase | |
| 6.3.2.29 | cyanophycin synthase (L-aspartate-adding) | False | 5 | 5731 | 11 | 12 | ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp | cyanophycin:L-aspartate ligase (ADP-forming) | None | CphA (ambiguous); CphA1 (ambiguous); CphA2 (ambiguous); cyanophycin synthetase (ambiguous); multi-L-arginyl-poly-L-aspartate synthase (ambiguous) | |
| 6.3.2.30 | cyanophycin synthase (L-arginine-adding) | False | 5 | 5443 | 0 | 16 | ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-Arg = ADP + phosphate + [L-Asp(4-L-Arg)]n+1 | cyanophycin:L-arginine ligase (ADP-forming) | None | CphA (ambiguous); CphA1 (ambiguous); CphA2 (ambiguous); cyanophycin synthetase (ambiguous); multi-L-arginyl-poly-L-aspartate synthase (ambiguous) | |
| 2.1.1.161 | dimethylglycine N-methyltransferase | False | 1 | 24 | 0 | 2 | S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine | S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming) | None | BsmB; DMT | |
| 2.1.1.162 | glycine/sarcosine/dimethylglycine N-methyltransferase | False | 0 | 1 | 0 | 2 | 3 S-adenosyl-L-methionine + glycine = 3 S-adenosyl-L-homocysteine + betaine (overall reaction);;(1a) S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine;;(1b) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine;;(1c) S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine | S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase [sarcosine(or N,N-dimethylglycine or betaine)-forming] | None | GSDMT; glycine sarcosine dimethylglycine N-methyltransferase | |
| 2.3.1.183 | phosphinothricin acetyltransferase | False | 5 | 1914 | 2 | 13 | acetyl-CoA + phosphinothricin = CoA + N-acetylphosphinothricin | acetyl-CoA:phosphinothricin N-acetyltransferase | None | PAT (ambiguous); PPT acetyltransferase; Pt-N-acetyltransferase | |
| 2.3.1.184 | acyl-homoserine-lactone synthase | False | 32 | 5805 | 1 | 31 | an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing) | None | acyl-homoserine lactone synthase; acyl homoserine lactone synthase; acyl-homoserinelactone synthase; acylhomoserine lactone synthase; AHL synthase; AHS; AHSL synthase; AhyI; AinS; AinS protein; autoinducer synthase; autoinducer synthesis protein rhlI; EsaI; ExpISCC1; ExpISCC3065; LasI; LasR; LuxI; LuxI protein; LuxM; N-acyl homoserine lactone synthase; RhlI; YspI ; acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing) | |
| 3.1.1.81 | quorum-quenching N-acyl-homoserine lactonase | False | 27 | 2394 | 5 | 55 | an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine | N-acyl-L-homoserine-lactone lactonohydrolase | None | acyl homoserine degrading enzyme; acyl-homoserine lactone acylase; AHL lactonase; AHL-degrading enzyme; AHL-inactivating enzyme; AHLase; AhlD; AhlK; AiiA; AiiA lactonase; AiiA-like protein; AiiB; AiiC; AttM; delactonase; lactonase-like enzyme; N-acyl homoserine lactonase; N-acyl homoserine lactone hydrolase; N-acyl-homoserine lactone lactonase; N-acyl-L-homoserine lactone hydrolase; quorum-quenching lactonase; quorum-quenching N-acyl homoserine lactone hydrolase | |
| 3.5.1.97 | acyl-homoserine-lactone acylase | False | 14 | 1684 | 18 | 26 | an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate | N-acyl-L-homoserine-lactone amidohydrolase | None | acyl-homoserine lactone acylase; AHL-acylase; AiiD; N-acyl-homoserine lactone acylase; PA2385 protein; quorum-quenching AHL acylase; quorum-quenching enzyme; QuiP | |
| 4.2.1.113 | o-succinylbenzoate synthase | False | 94 | 13414 | 8 | 6 | (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O | (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydro-lyase (2-succinylbenzoate-forming) | None | o-succinylbenzoic acid synthase; OSB synthase; OSBS; 2-succinylbenzoate synthase; MenC | |
| 4.2.2.22 | pectate trisaccharide-lyase | False | 5 | 101 | 1 | 6 | eliminative cleavage of unsaturated trigalacturonate as the major product from the reducing end of polygalacturonic acid/pectate | (1->4)-alpha-D-galacturonan reducing-end-trisaccharide-lyase | None | exopectate-lyase; pectate lyase A; PelA | |
| 5.1.1.18 | serine racemase | False | 9 | 109 | 15 | 19 | L-serine = D-serine | serine racemase | None | SRR | |
| 4.1.2.42 | D-threonine aldolase | False | 1 | 613 | 3 | 7 | (1) D-threonine = glycine + acetaldehyde;;(2) D-allo-threonine = glycine + acetaldehyde | D-threonine acetaldehyde-lyase (glycine-forming) | None | D-TA; DTA; low specificity D-TA; low specificity D-threonine aldolase | |
| 1.1.1.294 | chlorophyll(ide) b reductase | False | 4 | 35 | 0 | 7 | 71-hydroxychlorophyllide a + NAD(P)+ = chlorophyllide b + NAD(P)H + H+ | 71-hydroxychlorophyllide-a:NAD(P)+ oxidoreductase | None | chlorophyll b reductase; Chl b reductase | |
| 3.1.1.82 | pheophorbidase | False | 1 | 9 | 1 | 10 | pheophorbide a + H2O = pyropheophorbide a + methanol + CO2 (overall reaction);; (1a) pheophorbide a + H2O = C-132-carboxypyropheophorbide a + methanol;;(1b) C-132-carboxypyropheophorbide a = pyropheophorbide a + CO2 (spontaneous) | pheophorbide-a hydrolase | None | phedase; PPD | |
| 3.4.22.66 | calicivirin | False | 25 | 0 | 23 | 16 | Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu! and the P1' position is occupied by Gly! | None | None | Camberwell virus processing peptidase; Chiba virus processing peptidase; Norwalk virus processing peptidase; Southampton virus processing peptidase; Southampton virus; norovirus virus processing peptidase; calicivirus trypsin-like cysteine protease; calicivirus TCP; calicivirus 3C-like protease; calicivirus endopeptidase; rabbit hemorrhagic disease virus 3C endopeptidase | |
| 4.3.1.22 | 3,4-dihydroxyphenylalanine reductive deaminase | True | 0 | 0 | 0 | 1 | L-dopa + NADH = 3,4-dihydroxyphenylpropanoate + NAD+ + NH3 | 3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming) | None | reductive deaminase; DOPA-reductive deaminase; DOPARDA | |
| 5.1.3.23 | UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase | False | 1 | 516 | 0 | 2 | UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate | 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase | None | UDP-GlcNAc3NAcA 2-epimerase; UDP-alpha-D-GlcNAc3NAcA 2-epimerase; 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase; WbpI; WlbD | |
| 1.1.99.32 | L-sorbose 1-dehydrogenase | False | 1 | 44 | 0 | 3 | L-sorbose + acceptor = 1-dehydro-L-sorbose + reduced acceptor | L-sorbose:acceptor 1-oxidoreductase | None | SDH (ambiguous) | |
| 2.7.7.65 | diguanylate cyclase | False | 48 | 133846 | 22 | 37 | 2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate | GTP:GTP guanylyltransferase (cyclizing) | None | DGC; PleD | |
| 3.1.4.52 | cyclic-guanylate-specific phosphodiesterase | False | 20 | 17880 | 15 | 25 | cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine | cyclic bis(3'->5')diguanylate 3'-guanylylhydrolase | None | cyclic bis(3'->5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA | |
| 3.4.22.68 | Ulp1 peptidase | False | 2 | 230 | 8 | 8 | Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein | None | None | Smt3-protein conjugate proteinase; Ubl-specific protease 1; Ulp1; Ulp1 endopeptidase; Ulp1 protease | |
| 3.4.23.52 | preflagellin peptidase | False | 5 | 105 | 0 | 9 | Cleaves the signal peptide of 3 to 12 amino acids from the N-terminal of preflagellin, usually at Arg-Gly! or Lys-Gly!, to release flagellin. | None | None | FlaK | |
| 3.5.1.98 | histone deacetylase | False | 83 | 22584 | 189 | 29 | Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone | histone amidohydrolase | None | HDAC | |
| 4.3.1.23 | tyrosine ammonia-lyase | False | 6 | 35 | 0 | 9 | L-tyrosine = trans-p-hydroxycinnamate + NH3 | L-tyrosine ammonia-lyase (trans-p-hydroxycinnamate-forming) | None | TAL; tyrase; L-tyrosine ammonia-lyase | |
| 4.3.1.24 | phenylalanine ammonia-lyase | False | 67 | 3813 | 11 | 147 | L-phenylalanine = trans-cinnamate + NH3 | L-phenylalanine ammonia-lyase (trans-cinnamate-forming) | None | phenylalanine deaminase; phenylalanine ammonium-lyase; PAL; L-phenylalanine ammonia-lyase; Phe ammonia-lyase | |
| 4.3.1.25 | phenylalanine/tyrosine ammonia-lyase | False | 3 | 1 | 0 | 17 | (1) L-phenylalanine = trans-cinnamate + NH3;; (2) L-tyrosine = trans-p-hydroxycinnamate + NH3 | L-phenylalanine(or L-tyrosine):trans-cinnamate(or trans-p-hydroxycinnamate) ammonia-lyase | None | PTAL; bifunctional PAL | |
| 1.1.1.295 | momilactone-A synthase | False | 1 | 5 | 0 | 3 | 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P)+ = momilactone A + NAD(P)H + H+ | 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide:NAD(P)+ oxidoreductase | None | momilactone A synthase; OsMAS | |
| 2.2.1.9 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase | False | 263 | 12770 | 29 | 4 | isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 | isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating) | None | SEPHCHC synthase; MenD | |
| 1.3.7.6 | phycoerythrobilin synthase | False | 1 | 1 | 5 | 5 | (3Z)-phycoerythrobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin | (3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha) | None | PebS | |
| 2.3.1.185 | tropine acyltransferase | True | 0 | 0 | 0 | 5 | an acyl-CoA + tropine = CoA + an O-acyltropine | acyl-CoA:tropine O-acyltransferase | None | tropine:acyl-CoA transferase; acetyl-CoA:tropan-3-ol acyltransferase; tropine acetyltransferase; tropine tigloyltransferase; TAT | |
| 2.3.1.186 | pseudotropine acyltransferase | False | 0 | 4 | 0 | 6 | an acyl-CoA + pseudotropine = CoA + an O-acylpseudotropine | acyl-CoA:pseudotropine O-acyltransferase | None | pseudotropine:acyl-CoA transferase; tigloyl-CoA:pseudotropine acyltransferase; acetyl-CoA:pseudotropine acyltransferase; pseudotropine acetyltransferase; pseudotropine tigloyltransferase; PAT (ambiguous) | |
| 2.6.1.86 | 2-amino-4-deoxychorismate synthase | False | 1 | 10 | 0 | 6 | (2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine | (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase | None | ADIC synthase; 2-amino-2-deoxyisochorismate synthase; SgcD | |
| 2.7.1.161 | CTP-dependent riboflavin kinase | False | 47 | 2968 | 6 | 5 | CTP + riboflavin = CDP + FMN | CTP:riboflavin 5'-phosphotransferase | None | Methanocaldococcus jannaschii Mj0056; Mj0056 | |
| 2.7.1.162 | N-acetylhexosamine 1-kinase | False | 1 | 190 | 10 | 2 | ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate | ATP:N-acetyl-D-hexosamine 1-phosphotransferase | None | NahK; LnpB; N-acetylgalactosamine/N-acetylglucosamine 1-kinase | |
| 3.2.1.165 | exo-1,4-beta-D-glucosaminidase | False | 5 | 181 | 2 | 15 | Hydrolysis of chitosan or chitosan oligosaccharides to remove successive D-glucosamine residues from the non-reducing termini | chitosan exo-(1->4)-beta-D-glucosaminidase | None | CsxA; GlcNase; exochitosanase; GlmA; exo-beta-D-glucosaminidase; chitosan exo-1,4-beta-D-glucosaminidase | |
| 4.2.3.28 | ent-cassa-12,15-diene synthase | False | 2 | 0 | 0 | 1 | ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) | None | OsDTC1; OsKS7 | |
| 4.2.3.29 | ent-sandaracopimaradiene synthase | False | 1 | 0 | 0 | 3 | ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] | None | OsKS10; ent-sandaracopimara-8(14),15-diene synthase | |
| 4.2.3.30 | ent-pimara-8(14),15-diene synthase | False | 1 | 0 | 0 | 5 | ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] | None | OsKS5 | |
| 4.2.3.31 | ent-pimara-9(11),15-diene synthase | False | 1 | 3 | 0 | 1 | ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] | None | PMD synthase | |
| 4.2.3.32 | levopimaradiene synthase | False | 8 | 0 | 0 | 4 | (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming] | None | PtTPS-LAS; LPS; copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming] | |
| 4.2.3.33 | stemar-13-ene synthase | False | 1 | 0 | 0 | 2 | 9alpha-copalyl diphosphate = stemar-13-ene + diphosphate | 9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) | None | OsDTC2; OsK8; OsKL8; OsKS8; stemarene synthase; syn-stemar-13-ene synthase | |
| 4.2.3.34 | stemod-13(17)-ene synthase | False | 1 | 0 | 0 | 2 | 9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate | 9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] | None | OsKSL11; stemodene synthase | |
| 4.2.3.35 | syn-pimara-7,15-diene synthase | False | 2 | 0 | 0 | 3 | 9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate | 9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) | None | 9beta-pimara-7,15-diene synthase; OsDTS2; OsKS4 | |
| 5.5.1.14 | syn-copalyl-diphosphate synthase | False | 4 | 2 | 5 | 1 | geranylgeranyl diphosphate = 9alpha-copalyl diphosphate | 9alpha-copalyl-diphosphate lyase (ring-opening) | None | OsCyc1; OsCPSsyn; syn-CPP synthase; syn-copalyl diphosphate synthase; 9alpha-copalyl-diphosphate lyase (decyclizing) | |
| 1.1.1.296 | dihydrocarveol dehydrogenase | True | 0 | 0 | 0 | 1 | menth-8-en-2-ol + NAD+ = menth-8-en-2-one + NADH + H+ | menth-8-en-2-ol:NAD+ oxidoreductase | None | carveol dehydrogenase (ambiguous) | |
| 1.1.1.297 | limonene-1,2-diol dehydrogenase | True | 0 | 0 | 0 | 1 | menth-8-ene-1,2-diol + NAD+ = 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction);;(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ = (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+;;(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ = (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+ | menth-8-ene-1,2-diol:NAD+ oxidoreductase | None | NAD+-dependent limonene-1,2-diol dehydrogenase | |
| 1.3.99.25 | carvone reductase | True | 0 | 0 | 0 | 1 | (1) (+)-dihydrocarvone + acceptor = (-)-carvone + reduced acceptor;;(2) (-)-isodihydrocarvone + acceptor = (+)-carvone + reduced acceptor | (+)-dihydrocarvone:acceptor 1,6-oxidoreductase | None | None | |
| 1.14.13.105 | monocyclic monoterpene ketone monooxygenase | False | 1 | 0 | 0 | 1 | (1) (-)-menthone + NADPH + H+ + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O;;(2) dihydrocarvone + NADPH + H+ + O2 = 4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O;;(3) (iso)-dihydrocarvone + NADPH + H+ + O2 = 6-isopropenyl-3-methyloxepan-2-one + NADP+ + H2O;;(4a) 1-hydroxymenth-8-en-2-one + NADPH + H+ + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O;;(4b) 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate (spontaneous) | (-)-menthone,NADPH:oxygen oxidoreductase | None | 1-hydroxy-2-oxolimonene 1,2-monooxygenase; dihydrocarvone 1,2-monooxygenase; MMKMO | |
| 2.7.7.66 | malonate decarboxylase holo-[acyl-carrier protein] synthase | False | 17 | 833 | 0 | 1 | 2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein] = malonate decarboxylase holo-[acyl-carrier protein] + diphosphate | 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase | None | holo ACP synthase (ambiguous); 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase; MdcG; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase adenylyltransferase; holo-malonate-decarboxylase synthase (incorrect) | |
| 3.1.1.83 | monoterpene epsilon-lactone hydrolase | False | 1 | 603 | 0 | 1 | (1) isoprop(en)ylmethyloxepan-2-one + H2O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction);;(2) 4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate;;(3) 7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate | isoprop(en)ylmethyloxepan-2-one lactonohydrolase | None | MLH | |
| 3.5.4.33 | tRNA(adenine34) deaminase | False | 35 | 41359 | 10 | 9 | adenine34 in tRNA + H2O = hypoxanthine34 in tRNA + NH3 | tRNA(adenine34) aminohydrolase | None | tRNA:A34 deaminase; tadA protein; ADAT2-ADAT3 complex; TADA; tRNA adenosine deaminase arginine; AtTadA; tadA/ecADAT2; tRNA A:34 deaminase | |
| 4.2.3.36 | terpentetriene synthase | False | 1 | 0 | 0 | 1 | terpentedienyl diphosphate = terpentetriene + diphosphate | terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) | None | Cyc2 (ambiguous) | |
| 4.2.99.20 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | False | 64 | 5944 | 7 | 2 | 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate | 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming] | None | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase; 6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase; SHCHC synthase; MenH; YfbB | |
| 5.5.1.15 | terpentedienyl-diphosphate synthase | False | 1 | 5 | 0 | 2 | geranylgeranyl diphosphate = terpentedienyl diphosphate | terpentedienyl-diphosphate lyase (ring-opening) | None | terpentedienol diphosphate synthase; Cyc1; clerodadienyl diphosphate synthase; terpentedienyl-diphosphate lyase (decyclizing) | |
| 5.5.1.16 | halimadienyl-diphosphate synthase | False | 1 | 9 | 0 | 2 | geranylgeranyl diphosphate = tuberculosinyl diphosphate | halima-5,13-dien-15-yl-diphosphate lyase (ring-opening) | None | Rv3377c; halimadienyl diphosphate synthase; tuberculosinol diphosphate synthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing) | |
| 3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase | False | 44 | 4952 | 93 | 20 | adenosine 3',5'-cyclic phosphate + H2O = AMP | 3',5'-cyclic-AMP 5'-nucleotidohydrolase | None | cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2 | |
| 1.2.1.73 | sulfoacetaldehyde dehydrogenase | False | 1 | 169 | 0 | 2 | 2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+ | 2-sulfoacetaldehyde:NAD+ oxidoreductase | None | SafD | |
| 1.3.1.81 | (+)-pulegone reductase | False | 1 | 1 | 1 | 2 | (1) (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+;;(2) (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+ | (-)-menthone:NADP+ oxidoreductase | None | None | |
| 1.4.3.21 | primary-amine oxidase | False | 47 | 180 | 72 | 26 | RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 | primary-amine:oxygen oxidoreductase (deaminating) | None | amine oxidase (ambiguous); amine oxidase (copper-containing); amine oxidase (pyridoxal containing) (incorrect); benzylamine oxidase (incorrect); CAO (ambiguous); copper amine oxidase (ambiguous); Cu-amine oxidase (ambiguous); Cu-containing amine oxidase (ambiguous); diamine oxidase (incorrect); diamino oxhydrase (incorrect); histamine deaminase (ambiguous); histamine oxidase (ambiguous); monoamine oxidase (ambiguous); plasma monoamine oxidase (ambiguous); polyamine oxidase (ambiguous); semicarbazide-sensitive amine oxidase (ambiguous); SSAO (ambiguous) | |
| 1.4.3.22 | diamine oxidase | False | 6 | 6 | 5 | 37 | histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | histamine:oxygen oxidoreductase (deaminating) | None | amine oxidase (ambiguous); amine oxidase (copper-containing) (ambiguous); CAO (ambiguous); Cu-containing amine oxidase (ambiguous); copper amine oxidase (ambiguous); diamine oxidase (ambiguous); diamino oxhydrase (ambiguous); histaminase; histamine deaminase (incorrect); semicarbazide-sensitive amine oxidase (incorrect); SSAO (incorrect) | |
| 1.14.19.4 | acyl-lipid (11-3)-desaturase | False | 1 | 28 | 0 | 16 | (1) an (11Z,14Z)-icosa-11,14-dienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) an (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | acyl-lipid,ferrocytochrome b5:oxygen oxidoreductase [(11-3),(11-2)-cis-dehydrogenating] | None | acyl-lipid 8-desaturase; Delta8 fatty acid desaturase; Delta8-desaturase; Delta8-fatty-acid desaturase; efd1 (gene name); D8Des (gene name); phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase (incorrect); SLD | |
| 2.4.1.245 | alpha,alpha-trehalose synthase | False | 4 | 311 | 0 | 7 | NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + NDP | NDP-alpha-D-glucose:D-glucose 1-alpha-D-glucosyltransferase | None | trehalose synthase; trehalose synthetase; UDP-glucose:glucose 1-glucosyltransferase; TreT; PhGT; ADP-glucose:D-glucose 1-alpha-D-glucosyltransferase | |
| 3.1.26.12 | ribonuclease E | False | 9 | 12453 | 6 | 19 | Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions | None | None | endoribonuclease E; RNase E; Rne protein | |
| 3.4.11.24 | aminopeptidase S | False | 1 | 489 | 0 | 6 | Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues | None | None | Mername-AA022 peptidase; SGAP; aminopeptidase (Streptomyces griseus); Streptomyces griseus aminopeptidase; S. griseus AP; double-zinc aminopeptidase | |
| 1.3.1.82 | (-)-isopiperitenone reductase | False | 1 | 0 | 3 | 4 | (+)-cis-isopulegone + NADP+ = (-)-isopiperitenone + NADPH + H+ | (+)-cis-isopulegone:NADP+ oxidoreductase | None | None | |
| 1.14.19.5 | acyl-CoA 11-(Z)-desaturase | False | 4 | 4 | 0 | 17 | an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O | acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 cis-dehydrogenating) | None | Delta11 desaturase; fatty acid Delta11-desaturase; TpDESN; Cro-PG; Delta11 fatty acid desaturase; Z/E11-desaturase; Delta11-palmitoyl-CoA desaturase; acyl-CoA,hydrogen donor:oxygen Delta11-oxidoreductase; Delta11-fatty-acid desaturase | |
| 1.14.19.6 | acyl-CoA (9+3)-desaturase | False | 7 | 156 | 0 | 46 | (1) oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O;;(2) palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O | acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (12,13 cis-dehydrogenating) | None | oleoyl-CoA 12-desaturase; Delta12 fatty acid desaturase; Delta12(omega6)-desaturase; oleoyl-CoA Delta12 desaturase; Delta12 desaturase; Delta12-desaturase; Delta12-fatty-acid desaturase; acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase | |
| 1.13.12.15 | 3,4-dihydroxyphenylalanine oxidative deaminase | False | 0 | 0 | 1 | 2 | 2 L-dopa + O2 = 2 3,4-dihydroxyphenylpyruvate + 2 NH3 | 3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating) | None | 3,4-dihydroxy-L-phenylalanine: oxidative deaminase; oxidative deaminase; DOPA oxidative deaminase; DOPAODA | |
| 2.1.3.11 | N-succinylornithine carbamoyltransferase | False | 2 | 2642 | 0 | 2 | carbamoyl phosphate + N2-succinyl-L-ornithine = phosphate + N-succinyl-L-citrulline | carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase | None | succinylornithine transcarbamylase; N-succinyl-L-ornithine transcarbamylase; SOTCase | |
| 2.5.1.72 | quinolinate synthase | False | 248 | 32884 | 29 | 8 | glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate | glycerone phosphate:iminosuccinate alkyltransferase (cyclizing) | None | NadA; QS; quinolinate synthetase | |
| 3.1.3.78 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | False | 15 | 2385 | 1 | 3 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | None | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | |
| 3.2.2.26 | futalosine hydrolase | False | 3 | 3520 | 0 | 5 | futalosine + H2O = dehypoxanthine futalosine + hypoxanthine | futalosine ribohydrolase | None | futalosine nucleosidase; MqnB (ambiguous) | |
| 3.6.1.53 | Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase | False | 9 | 1112 | 0 | 4 | (1) CDP-choline + H2O = CMP + phosphocholine;;(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate | CDP-choline phosphohydrolase | None | Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase; ADPRibase-Mn | |
| 4.1.2.43 | 3-hexulose-6-phosphate synthase | False | 33 | 3803 | 1 | 28 | D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde | D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming) | None | D-arabino-3-hexulose 6-phosphate formaldehyde-lyase; 3-hexulosephosphate synthase; 3-hexulose phosphate synthase; HPS | |
| 5.1.99.5 | hydantoin racemase | False | 3 | 247 | 0 | 5 | D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin | D-5-monosubstituted-hydantoin racemase | None | 5'-monosubstituted-hydantoin racemase; HyuA; HyuE | |
| 5.3.1.27 | 6-phospho-3-hexuloisomerase | False | 4 | 559 | 0 | 15 | D-arabino-hex-3-ulose 6-phosphate = D-fructose 6-phosphate | D-arabino-hex-3-ulose-6-phosphate isomerase | None | 3-hexulose-6-phosphate isomerase; phospho-3-hexuloisomerase; PHI; 6-phospho-3-hexulose isomerase; YckF | |
| 2.1.3.10 | malonyl-S-ACP:biotin-protein carboxyltransferase | False | 2 | 195 | 3 | 1 | a malonyl-[acyl-carrier protein] + a biotinyl-[protein] = an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein] | malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxytransferase | None | malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase; MadC/MadD; MadC,D; malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase | |
| 2.3.1.187 | acetyl-S-ACP:malonate ACP transferase | False | 1 | 216 | 0 | 4 | an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate | acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase | None | acetyl-S-ACP:malonate ACP-SH transferase; acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase; MdcA; MadA; ACP transferase; malonate/acetyl-CoA transferase; malonate:ACP transferase; acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase | |
| 2.3.1.277 | 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase | False | 4 | 0 | 0 | 3 | a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein] | 3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase | None | afsA (gene name); scbA (gene name); barX (gene name) | |
| 4.1.1.87 | malonyl-[malonate decarboxylase] decarboxylase | False | 1 | 158 | 0 | 2 | a malonyl-[holo malonate decarboxylase acyl-carrier protein] = an acetyl-[holo malonate decarboxylase acyl-carrier protein] + CO2 | malonyl-[holo malonate decarboxylase acyl-carrier protein] carboxy-lyase | None | malonyl-S-ACP decarboxylase; malonyl-S-acyl-carrier protein decarboxylase; MdcD/MdcE; MdcD,E; malonyl-[acyl-carrier-protein] carboxy-lyase | |
| 4.1.1.88 | biotin-independent malonate decarboxylase | False | 0 | 1053 | 0 | 4 | malonate + H+ = acetate + CO2 | malonate carboxy-lyase (biotin-independent) | None | malonate decarboxylase (without biotin); malonate decarboxylase (ambiguous); MDC | |
| 6.2.1.35 | acetate---[acyl-carrier protein] ligase | False | 1 | 5 | 0 | 2 | ATP + acetate + an [acyl-carrier protein] = AMP + diphosphate + an acetyl-[acyl-carrier protein] | acetate:[acyl-carrier-protein] ligase (AMP-forming) | None | HS-acyl-carrier protein:acetate ligase; [acyl-carrier protein]:acetate ligase; MadH; ACP-SH:acetate ligase | |
| 4.2.3.37 | epi-isozizaene synthase | False | 1 | 4 | 30 | 2 | (2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] | None | SCO5222 protein | |
| 1.3.1.83 | geranylgeranyl diphosphate reductase | False | 5 | 1520 | 7 | 7 | phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH + 3 H+ | geranylgeranyl-diphosphate:NADP+ oxidoreductase | None | geranylgeranyl reductase; CHL P | |
| 4.2.3.43 | fusicocca-2,10(14)-diene synthase | False | 2 | 0 | 4 | 2 | geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate | geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming) | None | fusicoccadiene synthase; PaFS; PaDC4 | |
| 4.2.3.41 | elisabethatriene synthase | True | 0 | 0 | 0 | 1 | geranylgeranyl diphosphate = elisabethatriene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (elisabethatriene-forming) | None | elisabethatriene cyclase | |
| 4.2.3.42 | aphidicolan-16beta-ol synthase | False | 1 | 1 | 0 | 1 | 9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate | 9alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16beta-ol-forming) | None | PbACS | |
| 3.1.7.5 | geranylgeranyl diphosphate diphosphatase | True | 0 | 0 | 0 | 1 | geranylgeranyl diphosphate + H2O = geranylgeraniol + diphosphate | geranyl-diphosphate diphosphohydrolase | None | geranylgeranyl diphosphate phosphatase | |
| 1.2.1.74 | abieta-7,13-dien-18-al dehydrogenase | True | 0 | 0 | 0 | 1 | abieta-7,13-dien-18-al + H2O + NAD+ = abieta-7,13-dien-18-oate + NADH + H+ | abieta-7,13-dien-18-al:NAD+ oxidoreductase | None | abietadienal dehydrogenase (ambiguous) | |
| 1.1.5.3 | glycerol-3-phosphate dehydrogenase | False | 120 | 32794 | 0 | 17 | sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol | sn-glycerol 3-phosphate:quinone oxidoreductase | None | alpha-glycerophosphate dehydrogenase; alpha-glycerophosphate dehydrogenase (acceptor); anaerobic glycerol-3-phosphate dehydrogenase; DL-glycerol 3-phosphate oxidase (misleading); FAD-dependent glycerol-3-phosphate dehydrogenase; FAD-dependent sn-glycerol-3-phosphate dehydrogenase; FAD-GPDH; FAD-linked glycerol 3-phosphate dehydrogenase; FAD-linked L-glycerol-3-phosphate dehydrogenase; flavin-linked glycerol-3-phosphate dehydrogenase; flavoprotein-linked L-glycerol 3-phosphate dehydrogenase; glycerol 3-phosphate cytochrome c reductase (misleading); glycerol phosphate dehydrogenase; glycerol phosphate dehydrogenase (acceptor); glycerol phosphate dehydrogenase (FAD); glycerol-3-phosphate CoQ reductase; glycerol-3-phosphate dehydrogenase (flavin-linked); glycerol-3-phosphate:CoQ reductase; glycerophosphate dehydrogenase; L-3-glycerophosphate-ubiquinone oxidoreductase; L-glycerol-3-phosphate dehydrogenase (ambiguous); L-glycerophosphate dehydrogenase; mGPD; mitochondrial glycerol phosphate dehydrogenase; NAD+-independent glycerol phosphate dehydrogenase; pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase; sn-glycerol 3-phosphate oxidase (misleading); sn-glycerol-3-phosphate dehydrogenase; sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase; sn-glycerol-3-phosphate:acceptor 2-oxidoreductase | |
| 1.3.5.2 | dihydroorotate dehydrogenase (quinone) | False | 393 | 28785 | 106 | 23 | (S)-dihydroorotate + a quinone = orotate + a quinol | (S)-dihydroorotate:quinone oxidoreductase | None | dihydroorotate:ubiquinone oxidoreductase; (S)-dihydroorotate:(acceptor) oxidoreductase; (S)-dihydroorotate:acceptor oxidoreductase; DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); DHODH | |
| 3.1.3.79 | mannosylfructose-phosphate phosphatase | False | 1 | 107 | 0 | 1 | beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate + H2O = beta-D-fructofuranosyl-alpha-D-mannopyranoside + phosphate | beta-D-fructofuranosyl-alpha-D-mannopyranoside-6F-phosphate phosphohydrolase | None | mannosylfructose-6-phosphate phosphatase; MFPP | |
| 2.4.1.246 | mannosylfructose-phosphate synthase | False | 1 | 682 | 0 | 1 | GDP-mannose + D-fructose 6-phosphate = GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate | GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase | None | mannosylfructose-6-phosphate synthase; MFPS | |
| 1.14.13.107 | limonene 1,2-monooxygenase | False | 1 | 1266 | 0 | 1 | (1) (S)-limonene + NAD(P)H + H+ + O2 = 1,2-epoxymenth-8-ene + NAD(P)+ + H2O;;(2) (R)-limonene + NAD(P)H + H+ + O2 = 1,2-epoxymenth-8-ene + NAD(P)+ + H2O | limonene,NAD(P)H:oxygen oxidoreductase | None | None | |
| 1.17.7.1 | (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) | False | 27 | 2344 | 13 | 3 | (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin | (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase | None | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (ambiguous); gcpE (gene name); ISPG (gene name); (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | |
| 1.17.7.3 | (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) | False | 414 | 31559 | 0 | 2 | (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin | (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized flavodoxin oxidoreductase | None | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (ambiguous); ispG (gene name) | |
| 2.7.7.67 | CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase | False | 54 | 1949 | 1 | 3 | CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol | CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase | None | carS (gene name); CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-GG-GP ether cytidylyltransferase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase; CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase; CDP-unsaturated archaeol synthase; CDP-archaeol synthase (incorrect) | |
| 2.7.8.41 | cardiolipin synthase (CMP-forming) | False | 12 | 1150 | 0 | 14 | a CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP | CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming) | None | None | |
| 4.2.1.114 | methanogen homoaconitase | False | 9 | 307 | 1 | 2 | (R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction);;(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O;;(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate | (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming] | None | methanogen HACN | |
| 4.2.1.115 | UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) | False | 3 | 2664 | 3 | 6 | UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O | UDP-N-acetyl-alpha-D-glucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose-forming) | None | FlaA1; UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase; PseB; UDP-N-acetylglucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose-forming) | |
| 4.2.3.38 | alpha-bisabolene synthase | False | 4 | 0 | 6 | 6 | (2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] | None | bisabolene synthase | |
| 4.2.3.39 | epi-cedrol synthase | False | 1 | 2 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) | None | 8-epicedrol synthase; epicedrol synthase | |
| 4.2.3.40 | (Z)-gamma-bisabolene synthase | False | 3 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] | None | None | |
| 4.2.3.44 | isopimara-7,15-diene synthase | False | 4 | 0 | 0 | 2 | (+)-copalyl diphosphate = isopimara-7,15-diene + diphosphate | (+)-copalyl diphosphate-lyase (isopimara-7,15-diene-forming) | None | PaTPS-Iso; copalyl diphosphate-lyase (isopimara-7,15-diene-forming) | |
| 1.5.3.14 | polyamine oxidase (propane-1,3-diamine-forming) | False | 1 | 16 | 1 | 3 | spermidine + O2 + H2O = propane-1,3-diamine + 4-aminobutanal + H2O2 | spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) | None | MPAO (ambiguous); maize PAO | |
| 1.5.3.13 | N1-acetylpolyamine oxidase | False | 3 | 23 | 4 | 7 | (1) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2;; (2) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 | N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming) | None | hPAO-1; PAO (ambiguous); mPAO; hPAO; polyamine oxidase (ambiguous) | |
| 1.5.3.15 | N8-acetylspermidine oxidase (propane-1,3-diamine-forming) | False | 1 | 0 | 0 | 1 | N8-acetylspermidine + O2 + H2O = propane-1,3-diamine + 4-acetamidobutanal + H2O2 | N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) | None | None | |
| 1.5.3.16 | spermine oxidase | False | 4 | 58 | 2 | 9 | spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 | spermidine:oxygen oxidoreductase (spermidine-forming) | None | PAOh1/SMO; PAOh1 (ambiguous); AtPAO1; AtPAO4; SMO; mSMO; SMO(PAOh1); SMO/PAOh1; SMO5; mSMOmu | |
| 1.5.3.17 | non-specific polyamine oxidase | False | 3 | 30 | 3 | 10 | (1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2;;(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2;;(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2;;(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 | polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming) | None | polyamine oxidase (ambiguous); Fms1; AtPAO3 | |
| 1.1.1.298 | 3-hydroxypropionate dehydrogenase (NADP+) | False | 36 | 3453 | 1 | 6 | 3-hydroxypropanoate + NADP+ = malonate semialdehyde + NADPH + H+ | 3-hydroxypropanoate:NADP+ oxidoreductase | None | 3-hydroxypropanoate dehydrogenase (NADP+); 3-hydroxypropionate:NADP+ oxidoreductase | |
| 1.1.1.299 | malate dehydrogenase [NAD(P)+] | False | 6 | 2 | 2 | 3 | (S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+ | (S)-malate:NAD(P)+ oxidoreductase | None | MdH II, NAD(P)+-dependent malate dehyrogenase | |
| 1.1.1.300 | NADP-retinol dehydrogenase | False | 37 | 5231 | 30 | 11 | retinol + NADP+ = retinal + NADPH + H+ | retinol:NADP+ oxidoreductase | None | all-trans retinal reductase (ambiguous); all-trans-retinol dehydrogenase; NADP(H)-dependent retinol dehydrogenase/reductase; RDH11; RDH12; RDH13; RDH14; retinol dehydrogenase 12; retinol dehydrogenase 14; retinol dehydrogenase [NADP+]; RalR1; PSDR1 | |
| 1.1.5.4 | malate dehydrogenase (quinone) | False | 184 | 11523 | 0 | 15 | (S)-malate + a quinone = oxaloacetate + reduced quinone | (S)-malate:quinone oxidoreductase | None | FAD-dependent malate-vitamin K reductase; malate-vitamin K reductase; (S)-malate:(acceptor) oxidoreductase; L-malate-quinone oxidoreductase; malate:quinone oxidoreductase; malate quinone oxidoreductase; MQO; malate:quinone reductase; malate dehydrogenase (acceptor); FAD-dependent malate dehydrogenase | |
| 1.2.1.75 | malonyl-CoA reductase (malonate semialdehyde-forming) | False | 2 | 4 | 5 | 4 | malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+ | malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming) | None | NADP-dependent malonyl CoA reductase; malonyl CoA reductase (NADP); malonyl CoA reductase (malonate semialdehyde-forming) | |
| 1.2.1.76 | succinate-semialdehyde dehydrogenase (acylating) | False | 2 | 284 | 3 | 2 | succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ | succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating) | None | succinyl-coA reductase; coenzyme-A-dependent succinate-semialdehyde dehydrogenase | |
| 1.3.1.84 | acrylyl-CoA reductase (NADPH) | False | 5 | 548 | 2 | 5 | propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ | propanoyl-CoA:NADP+ oxidoreductase | None | None | |
| 1.13.12.16 | nitronate monooxygenase | False | 3 | 2401 | 4 | 7 | ethylnitronate + O2 = acetaldehyde + nitrite + other products | nitronate:oxygen 2-oxidoreductase (nitrite-forming) | None | NMO; 2-nitropropane dioxygenase (incorrect) | |
| 1.13.12.18 | dinoflagellate luciferase | False | 1 | 6 | 0 | 6 | dinoflagellate luciferin + O2 = oxidized dinoflagellate luciferin + H2O + hnu | dinoflagellate-luciferin:oxygen 132-oxidoreductase | None | (dinoflagellate luciferin) luciferase; Gonyaulax luciferase | |
| 2.1.1.163 | demethylmenaquinone methyltransferase | False | 387 | 33704 | 0 | 5 | a demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine | S-adenosyl-L-methione:demethylmenaquinone methyltransferase | None | S-adenosyl-L-methione---DMK methyltransferase; demethylmenaquinone C-methylase; 2-heptaprenyl-1,4-naphthoquinone methyltransferase; 2-demethylmenaquinone methyltransferase; S-adenosyl-L-methione:2-demethylmenaquinone methyltransferase | |
| 2.3.1.188 | omega-hydroxypalmitate O-feruloyl transferase | False | 1 | 54 | 0 | 5 | feruloyl-CoA + 16-hydroxypalmitate = CoA + 16-feruloyloxypalmitate | feruloyl-CoA:16-hydroxypalmitate feruloyltransferase | None | hydroxycinnamoyl-CoA omega-hydroxypalmitic acid O-hydroxycinnamoyltransferase; HHT | |
| 2.4.1.247 | beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase | False | 1 | 40 | 0 | 2 | beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = L-rhamnose + alpha-D-galactose 1-phosphate | beta-D-galactosyl-(1->4)-L-rhamnose:phosphate 1-alpha-D-galactosyltransferase | None | D-galactosyl-beta1->4-L-rhamnose phosphorylase; GalRhaP | |
| 2.4.1.248 | cycloisomaltooligosaccharide glucanotransferase | False | 2 | 59 | 8 | 3 | cyclizes part of a (1->6)-alpha-D-glucan chain by formation of a (1->6)-alpha-D-glucosidic bond | (1->6)-alpha-D-glucan:(1->6)-alpha-D-glucan 6-alpha-D-[1->6alpha-D-glucano]-transferase (cyclizing) | None | None | |
| 2.4.1.249 | delphinidin 3',5'-O-glucosyltransferase | True | 0 | 0 | 0 | 1 | 2 UDP-glucose + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside = 2 UDP + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3',5'-di-O-beta-D-glucoside (overall reaction);;(1a) UDP-glucose + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside = UDP + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside;;(1b) UDP-glucose + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside = UDP + delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3',5'-di-O-beta-D-glucoside | UDP-glucose:delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside 3'-O-glucosyltransferase | None | UDP-glucose:anthocyanin 3',5'-O-glucosyltransferase; UA3'5'GZ | |
| 2.4.2.41 | xylogalacturonan beta-1,3-xylosyltransferase | False | 1 | 180 | 0 | 1 | Transfers a xylosyl residue from UDP-D-xylose to a D-galactose residue in xylogalacturonan, forming a beta-1,3-D-xylosyl-D-galactose linkage. | UDP-D-xylose:xylogalacturonan 3-beta-D-xylosyltransferase | None | xylogalacturonan xylosyltransferase; XGA xylosyltransferase | |
| 2.5.1.73 | O-phospho-L-seryl-tRNA:Cys-tRNA synthase | False | 26 | 632 | 2 | 8 | O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate | O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase | None | SepCysS; Sep-tRNA:Cys-tRNA synthase | |
| 2.5.1.74 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | False | 7 | 15047 | 0 | 4 | an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinone + diphosphate + CO2 | all-trans-polyprenyl-diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase | None | None | |
| 2.5.1.75 | tRNA dimethylallyltransferase | False | 792 | 44541 | 0 | 15 | prenyl diphosphate + adenosine37 in tRNA = diphosphate + N6-(3-methylbut-2-en-1-yl)-adenosine37 in tRNA | prenyl-diphosphate:adenine37 in tRNA prenyltransferase | None | tRNA prenyltransferase; MiaA; transfer ribonucleate isopentenyltransferase (incorrect); Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase (incorrect); Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase (incorrect); dimethylallyl-diphosphate: tRNA dimethylallyltransferase; dimethylallyl-diphosphate:adenine37 in tRNA dimethylallyltransferase | |
| 2.5.1.76 | cysteate synthase | False | 12 | 519 | 0 | 1 | O-phospho-L-serine + sulfite = L-cysteate + phosphate | sulfite:O-phospho-L-serine sulfonotransferase (phosphate-hydrolysing, L-cysteate-forming) | None | sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming) | |
| 2.7.1.163 | hygromycin B 4-O-kinase | False | 1 | 24 | 8 | 3 | ATP + hygromycin B = ADP + 4-O-phosphohygromycin B | ATP:hygromycin-B 4-O-phosphotransferase | None | hygromycin-B kinase (ambiguous) | |
| 2.7.1.164 | O-phosphoseryl-tRNASec kinase | False | 5 | 60 | 1 | 5 | ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec | ATP:L-seryl-tRNASec O-phosphotransferase | None | PSTK; phosphoseryl-tRNA[Ser]Sec kinase; phosphoseryl-tRNASec kinase | |
| 2.9.1.2 | O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase | False | 12 | 2169 | 6 | 8 | O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + 2 phosphate | selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase | None | MMPSepSecS; SepSecS; SLA/LP; O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase; O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase | |
| 3.1.26.13 | retroviral ribonuclease H | False | 71 | 1 | 8 | 6 | Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA [1-4]. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction [5]. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end [6,7]. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus [8-10]. | None | None | RT/RNase H; retroviral reverse transcriptase RNaseH (gene name); HIV RNase H | |
| 3.2.2.27 | uracil-DNA glycosylase | False | 428 | 49036 | 93 | 44 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil | uracil-DNA deoxyribohydrolase (uracil-releasing) | None | UdgB (ambiguous); uracil-DNA N-glycosylase; UDG (ambiguous); uracil DNA glycohydrolase | |
| 3.2.2.28 | double-stranded uracil-DNA glycosylase | False | 51 | 1886 | 0 | 3 | Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil | uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing) | None | Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous) | |
| 3.2.2.29 | thymine-DNA glycosylase | False | 5 | 33 | 18 | 5 | Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. | thymine-DNA deoxyribohydrolase (thymine-releasing) | None | mismatch-specific thymine-DNA glycosylase; mismatch-specific thymine-DNA N-glycosylase; hTDG; hsTDG; TDG; thymine DNA glycosylase; G/T glycosylase; uracil/thymine DNA glycosylase; T:G mismatch-specific thymidine-DNA glycosylase; G:T mismatch-specific thymine DNA-glycosylase | |
| 3.4.17.23 | angiotensin-converting enzyme 2 | False | 7 | 45 | 175 | 29 | angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine | None | None | ACE-2; ACE2; hACE2; angiotensin converting enzyme 2; angiotensin converting enzyme-2; Tmem27 | |
| 3.4.22.69 | SARS coronavirus main proteinase | False | 23 | 1 | 1445 | 7 | TSAVLQ!SGFRK-NH2 and SGVTFQ!GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. | None | None | 3cLpro; 3C-like protease; coronavirus 3C-like protease; Mpro; SARS 3C-like protease; SARS coronavirus 3CL protease; SARS coronavirus main peptidase; SARS coronavirus main protease; SARS-CoV 3CLpro enzyme; SARS-CoV main protease; SARS-CoV Mpro; severe acute respiratory syndrome coronavirus main protease | |
| 3.4.22.70 | sortase A | False | 3 | 436 | 5 | 16 | The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. | None | None | SrtA; SrtA protein; SrtA sortase | |
| 3.4.22.71 | sortase B | False | 1 | 1726 | 2 | 7 | The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved between the Thr and Asn residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. | None | None | SrtB | |
| 3.4.23.50 | human endogenous retrovirus K endopeptidase | False | 13 | 95 | 1 | 2 | Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY!PIVQ- cleavage site. | None | None | human endogenous retrovirus K10 endopeptidase; endogenous retrovirus HERV-K10 putative protease; human endogenous retrovirus K retropepsin; HERV K10 endopeptidase; HERV K10 retropepsin; HERV-K PR; HERV-K protease; HERV-K113 protease; human endogenous retrovirus K113 protease; human retrovirus K10 retropepsin | |
| 3.4.23.51 | HycI peptidase | False | 2 | 1025 | 0 | 1 | This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of hydrogenase 3 in Escherichia coli by cleavage at the C-terminal side of Arg537. | None | None | HycI; HycE processing protein | |
| 3.4.24.87 | ADAMTS13 endopeptidase | False | 2 | 7 | 3 | 8 | The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain | None | None | ADAMTS VWF cleaving metalloprotease; ADAMTS-13; ADAMTS13; vWF-cleaving protease; VWF-CP; vWF-degrading protease; Upshaw factor; von Willebrand factor cleaving protease; ADAMTS13 peptidase | |
| 3.4.25.2 | HslU---HslV peptidase | False | 430 | 18935 | 7 | 14 | ATP-dependent cleavage of peptide bonds with broad specificity. | None | None | HslUV; HslV-HslU; HslV peptidase; ATP-dependent HslV-HslU proteinase; caseinolytic protease X; caseinolytic proteinase X; ClpXP ATP-dependent protease; ClpXP protease; ClpXP serine proteinase; Escherichia coli ClpXP serine proteinase; HslUV protease; HslUV proteinase; HslVU protease; HslVU proteinase; protease HslVU; proteinase HslUV | |
| 3.5.1.99 | fatty acid amide hydrolase | False | 10 | 436 | 15 | 8 | (1) anandamide + H2O = arachidonic acid + ethanolamine;;(2) oleamide + H2O = oleic acid + NH3 | fatty acylamide amidohydrolase | None | FAAH; oleamide hydrolase; anandamide amidohydrolase | |
| 3.5.1.100 | (R)-amidase | False | 1 | 1537 | 0 | 2 | (1) (R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH3;;(2) beta-alaninamide + H2O = beta-alanine + NH3 | (R)-piperazine-2-carboxamide amidohydrolase | None | R-stereospecific amidase; R-amidase | |
| 3.5.1.101 | L-proline amide hydrolase | False | 2 | 163 | 0 | 1 | (1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylate + NH3;;(2) L-prolinamide + H2O = L-proline + NH3 | (S)-piperidine-2-carboxamide amidohydrolase | None | S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase; LaaA; L-amino acid amidase | |
| 3.7.1.11 | cyclohexane-1,2-dione hydrolase | False | 1 | 10 | 2 | 1 | cyclohexane-1,2-dione + H2O = 6-oxohexanoate | cyclohexane-1,2-dione acylhydrolase (ring-opening) | None | cyclohexane-1,2-dione acylhydrolase (decyclizing) | |
| 4.1.1.90 | peptidyl-glutamate 4-carboxylase | False | 7 | 888 | 0 | 8 | peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = peptidyl-glutamate + CO2 + O2 + phylloquinol | peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinol-epoxidizing) | None | vitamin K-dependent carboxylase; gamma-glutamyl carboxylase; peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing) | |
| 4.1.99.13 | (6-4)DNA photolyase | False | 3 | 159 | 2 | 16 | (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA) | (6-4) photoproduct pyrimidine-lyase | None | DNA photolyase; H64PRH; NF-10; phr (6-4); PL-(6-4); OtCPF1; (6-4) PHR; At64PHR | |
| 4.1.99.14 | spore photoproduct lyase | False | 3 | 978 | 3 | 4 | (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA) = thymidylyl-(3'->5')-thymidylate (in double-helical DNA) | spore photoproduct pyrimidine-lyase | None | SAM; SP lyase; SPL; SplB; SplG | |
| 4.2.1.116 | 3-hydroxypropionyl-CoA dehydratase | False | 1 | 179 | 1 | 2 | 3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O | 3-hydroxypropanoyl-CoA hydro-lyase | None | 3-hydroxypropionyl-CoA hydro-lyase; 3-hydroxypropanoyl-CoA dehydratase | |
| 4.2.1.117 | 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) | False | 1 | 67 | 0 | 1 | (2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate-forming) | None | None | |
| 4.2.1.118 | 3-dehydroshikimate dehydratase | False | 5 | 4073 | 1 | 12 | 3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O | 3-dehydroshikimate hydro-lyase | None | None | |
| 4.2.1.119 | enoyl-CoA hydratase 2 | False | 16 | 585 | 2 | 14 | (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H2O | (3R)-3-hydroxyacyl-CoA hydro-lyase | None | 2-enoyl-CoA hydratase 2; AtECH2; ECH2; MaoC; MFE-2; PhaJAc; D-3-hydroxyacyl-CoA hydro-lyase; D-specific 2-trans-enoyl-CoA hydratase | |
| 4.2.1.120 | 4-hydroxybutanoyl-CoA dehydratase | False | 1 | 283 | 0 | 5 | 4-hydroxybutanoyl-CoA = (E)-but-2-enoyl-CoA + H2O | 4-hydroxybutanoyl-CoA hydro-lyase | None | None | |
| 4.2.3.45 | phyllocladan-16alpha-ol synthase | False | 1 | 0 | 0 | 1 | (+)-copalyl diphosphate + H2O = phyllocladan-16alpha-ol + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase (phyllocladan-16alpha-ol-forming) | None | PaDC1 | |
| 4.99.1.8 | heme ligase | False | 1 | 3 | 0 | 3 | 2 ferriprotoporphyrin IX = beta-hematin | Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming) | None | heme detoxification protein; HDP; hemozoin synthase | |
| 6.1.1.27 | O-phospho-L-serine---tRNA ligase | False | 21 | 573 | 1 | 7 | ATP + O-phospho-L-serine + tRNACys = AMP + diphosphate + O-phospho-L-seryl-tRNACys | O-phospho-L-serine:tRNACys ligase (AMP-forming) | None | O-phosphoseryl-tRNA ligase; non-canonical O-phosphoseryl-tRNA synthetase; SepRS | |
| 6.2.1.36 | 3-hydroxypropionyl-CoA synthase | False | 2 | 57 | 0 | 2 | 3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate | hydroxypropanoate:CoA ligase (AMP-forming) | None | 3-hydroxypropionyl-CoA synthetase (AMP-forming); 3-hydroxypropionate---CoA ligase | |
| 6.3.1.13 | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | False | 81 | 4140 | 3 | 3 | 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP = 1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate | L-cysteine:1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol ligase (AMP-forming) | None | MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase | |
| 1.1.5.5 | alcohol dehydrogenase (quinone) | False | 7 | 121 | 1 | 20 | ethanol + ubiquinone = acetaldehyde + ubiquinol | alcohol:quinone oxidoreductase | None | type III ADH; membrane associated quinohaemoprotein alcohol dehydrogenase | |
| 1.1.1.301 | D-arabitol-phosphate dehydrogenase | False | 1 | 357 | 0 | 2 | D-arabinitol 1-phosphate + NAD+ = D-xylulose 5-phosphate + NADH + H+ | D-arabinitol-phosphate:NAD+ oxidoreductase | None | APDH; D-arabitol 1-phosphate dehydrogenase; D-arabitol 5-phosphate dehydrogenase; D-arabinitol 1-phosphate dehydrogenase; D-arabinitol 5-phosphate dehydrogenase | |
| 1.1.5.7 | cyclic alcohol dehydrogenase (quinone) | True | 0 | 0 | 0 | 1 | a cyclic alcohol + a quinone = a cyclic ketone + a quinol | cyclic alcohol:quinone oxidoreductase | None | cyclic alcohol dehydrogenase; MCAD | |
| 1.2.1.77 | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) | False | 1 | 204 | 0 | 2 | 3,4-didehydroadipyl-CoA semialdehyde + NADP+ + H2O = 3,4-didehydroadipyl-CoA + NADPH + H+ | 3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase | None | BoxD; 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | |
| 1.4.3.23 | 7-chloro-L-tryptophan oxidase | False | 2 | 72 | 11 | 1 | 7-chloro-L-tryptophan + O2 = 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2 | 7-chloro-L-tryptophan:oxygen oxidoreductase | None | RebO | |
| 1.7.5.1 | nitrate reductase (quinone) | False | 20 | 7871 | 1 | 9 | nitrate + a quinol = nitrite + a quinone + H2O | nitrite:quinone oxidoreductase | None | nitrate reductase A; nitrate reductase Z; quinol/nitrate oxidoreductase; quinol-nitrate oxidoreductase; quinol:nitrate oxidoreductase; NarA; NarZ; NarGHI; dissimilatory nitrate reductase | |
| 1.8.1.16 | glutathione amide reductase | False | 1 | 218 | 0 | 1 | 2 glutathione amide + NAD+ = glutathione amide disulfide + NADH + H+ | glutathione amide:NAD+ oxidoreductase | None | GAR | |
| 1.11.1.17 | glutathione amide-dependent peroxidase | False | 1 | 10 | 0 | 1 | 2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O | glutathione amide:hydrogen-peroxide oxidoreductase | None | None | |
| 1.13.12.17 | dichloroarcyriaflavin A synthase | True | 0 | 0 | 0 | 3 | dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+ = dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+ | dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming) | None | None | |
| 1.14.13.111 | methanesulfonate monooxygenase (NADH) | False | 4 | 50 | 0 | 6 | methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O | methanesulfonate,NADH:oxygen oxidoreductase | None | mesylate monooxygenase; mesylate,reduced-FMN:oxygen oxidoreductase; MsmABC; methanesulfonic acid monooxygenase; MSA monooxygenase; MSAMO | |
| 1.14.15.8 | steroid 15beta-monooxygenase | False | 1 | 0 | 0 | 2 | progesterone + 2 reduced [2Fe-2S] ferredoxin + O2 = 15beta-hydroxyprogesterone + 2 oxidized [2Fe-2S] ferredoxin + H2O | progesterone,reduced-ferredoxin:oxygen oxidoreductase (15beta-hydroxylating) | None | cytochrome P-450meg; cytochrome P450meg; steroid 15beta-hydroxylase; CYP106A2; BmCYP106A2 | |
| 1.14.99.39 | ammonia monooxygenase | False | 2 | 3736 | 0 | 22 | NH3 + a reduced acceptor + O2 = NH2OH + an acceptor + H2O | ammonia,donor:oxygen oxidoreductase (hydroxylamine-producing) | None | AMO | |
| 2.1.1.164 | demethylrebeccamycin-D-glucose O-methyltransferase | False | 1 | 1075 | 0 | 1 | 4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine | S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase | None | RebM | |
| 2.1.1.165 | methyl halide transferase | False | 0 | 4 | 0 | 18 | S-adenosyl-L-methionine + iodide = S-adenosyl-L-homocysteine + methyl iodide | S-adenosylmethionine:iodide methyltransferase | None | MCT; methyl chloride transferase; S-adenosyl-L-methionine:halide/bisulfide methyltransferase; AtHOL1; AtHOL2; AtHOL3; HARMLESS TO OZONE LAYER protein; HMT; S-adenosyl-L-methionine: halide ion methyltransferase; SAM:halide ion methyltransferase | |
| 2.3.1.189 | mycothiol synthase | False | 81 | 5499 | 0 | 5 | desacetylmycothiol + acetyl-CoA = CoA + mycothiol | acetyl-CoA:desacetylmycothiol O-acetyltransferase | None | MshD | |
| 2.4.1.250 | D-inositol-3-phosphate glycosyltransferase | False | 70 | 7207 | 1 | 3 | UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | UDP-N-acetyl-alpha-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase (configuration-retaining) | None | mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase | |
| 2.4.2.42 | UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase | False | 8 | 2486 | 0 | 2 | UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine | UDP-alpha-D-xylose:[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining) | None | beta-glucoside alpha-1,3-xylosyltransferase; UDP-alpha-D-xylose:beta-D-glucoside 3-alpha-D-xylosyltransferase; GXYLT1 (gene name); GXYLT2 (gene name) | |
| 2.7.7.68 | 2-phospho-L-lactate guanylyltransferase | False | 43 | 2315 | 2 | 1 | (2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate | GTP:2-phospho-L-lactate guanylyltransferase | None | cofC (gene name) (ambiguous) | |
| 2.7.8.28 | 2-phospho-L-lactate transferase | False | 42 | 4883 | 5 | 2 | (1) (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + factor 420-0;;(2) enolpyruvoyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + dehydro factor 420-0;;(3) 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + 3PG-factor 420-0 | (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase | None | cofD (gene name); fbiA (gene name); LPPG:Fo 2-phospho-L-lactate transferase; LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase; lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase | |
| 3.1.3.80 | 2,3-bisphosphoglycerate 3-phosphatase | False | 7 | 1501 | 0 | 3 | 2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate | 2,3-bisphospho-D-glycerate 3-phosphohydrolase | None | MIPP1; 2,3-BPG 3-phosphatase | |
| 3.5.1.102 | 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase | False | 18 | 130 | 0 | 1 | 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate | 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase | None | ArfB | |
| 3.5.1.103 | N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase | False | 66 | 3676 | 1 | 2 | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate | 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase | None | MshB | |
| 4.1.2.44 | 2,3-epoxybenzoyl-CoA dihydrolase | False | 1 | 385 | 0 | 1 | 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate | 2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming) | None | 2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating); BoxC; dihydrodiol transforming enzyme; benzoyl-CoA oxidation component C; 2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming); benzoyl-CoA-dihydrodiol lyase (incorrect); 2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming) | |
| 4.3.3.5 | 4'-demethylrebeccamycin synthase | False | 1 | 175 | 0 | 1 | 4'-O-demethylrebeccamycin + H2O = dichloro-arcyriaflavin A + beta-D-glucose | 4'-demethylrebeccamycin D-glucose-lyase | None | arcyriaflavin A N-glycosyltransferase; RebG | |
| 1.1.1.302 | 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase | False | 12 | 3712 | 3 | 4 | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+ | 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase | None | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; MjaRED; MJ0671 (gene name) | |
| 1.1.1.303 | diacetyl reductase [(R)-acetoin forming] | False | 1 | 245 | 0 | 4 | (R)-acetoin + NAD+ = diacetyl + NADH + H+ | (R)-acetoin:NAD+ oxidoreductase | None | (R)-acetoin dehydrogenase | |
| 1.1.1.304 | diacetyl reductase [(S)-acetoin forming] | False | 11 | 3236 | 1 | 9 | (S)-acetoin + NAD+ = diacetyl + NADH + H+ | (S)-acetoin:NAD+ oxidoreductase | None | (S)-acetoin dehydrogenase | |
| 1.2.1.78 | 2-formylbenzoate dehydrogenase | False | 1 | 33 | 0 | 2 | 2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ | 2-formylbenzoate:NAD+ oxidoreductase | None | 2-carboxybenzaldehyde dehydrogenase; 2CBAL dehydrogenase; PhdK | |
| 1.4.5.1 | D-amino acid dehydrogenase (quinone) | False | 3 | 47 | 0 | 3 | a D-amino acid + H2O + a quinone = a 2-oxo carboxylate + NH3 + a quinol | D-amino acid:quinone oxidoreductase (deaminating) | None | DadA | |
| 1.5.99.13 | D-proline dehydrogenase | False | 1 | 2 | 0 | 2 | D-proline + acceptor = 1-pyrroline-2-carboxylate + reduced acceptor | D-proline:acceptor oxidoreductase | None | D-Pro DH; D-Pro dehydrogenase; dye-linked D-proline dehydrogenase | |
| 1.14.13.113 | FAD-dependent urate hydroxylase | False | 6 | 1333 | 0 | 3 | urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O | urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming) | None | HpxO enzyme; FAD-dependent urate oxidase; urate hydroxylase | |
| 1.20.4.3 | mycoredoxin | False | 2 | 191 | 1 | 5 | arseno-mycothiol + mycoredoxin = arsenite + mycothiol-mycoredoxin disulfide | arseno-mycothiol:mycoredoxin oxidoreductase | None | Mrx1; MrxI | |
| 2.3.1.190 | acetoin dehydrogenase system | False | 0 | 114 | 0 | 9 | acetoin + CoA + NAD+ = acetaldehyde + acetyl-CoA + NADH + H+ | acetyl-CoA:acetoin O-acetyltransferase | None | acetoin dehydrogenase complex; acetoin dehydrogenase enzyme system; AoDH ES; acetoin dehydrogenase | |
| 2.5.1.78 | 6,7-dimethyl-8-ribityllumazine synthase | False | 616 | 40745 | 44 | 70 | 1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate | 5-amino-6-(D-ribitylamino)uracil butanedionetransferase | None | lumazine synthase; 6,7-dimethyl-8-ribityllumazine synthase 2; 6,7-dimethyl-8-ribityllumazine synthase 1; lumazine synthase 2; lumazine synthase 1; type I lumazine synthase; type II lumazine synthase; RIB4; MJ0303; RibH; Pbls; MbtLS; RibH1 protein; RibH2 protein; RibH1; RibH2 | |
| 2.5.1.79 | thermospermine synthase | False | 6 | 5 | 0 | 6 | S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+ | S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase (thermospermine-forming) | None | TSPMS; ACL5; SAC51; S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing) | |
| 2.5.1.80 | 7-dimethylallyltryptophan synthase | False | 1 | 0 | 0 | 5 | prenyl diphosphate + L-tryptophan = diphosphate + 7-prenyl-L-tryptophan | prenyl-diphosphate:L-tryptophan 7-prenyltransferase | None | 7-DMATS; dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase | |
| 2.7.1.165 | glycerate 2-kinase | False | 5 | 1229 | 0 | 15 | ATP + D-glycerate = ADP + 2-phospho-D-glycerate | ATP:D-glycerate 2-phosphotransferase | None | D-glycerate-2-kinase; glycerate kinase (2-phosphoglycerate forming); ATP:(R)-glycerate 2-phosphotransferase | |
| 2.8.4.2 | arsenate-mycothiol transferase | False | 4 | 466 | 0 | 1 | arsenate + mycothiol = arseno-mycothiol + H2O | mycothiol:arsenate S-arsenotransferase | None | ArsC1; ArsC2; mycothiol:arsenate transferase | |
| 3.1.1.84 | cocaine esterase | False | 3 | 789 | 2 | 3 | cocaine + H2O = ecgonine methyl ester + benzoate | cocaine benzoylhydrolase | None | CocE; hCE2; hCE-2; human carboxylesterase 2 | |
| 4.1.2.45 | trans-o-hydroxybenzylidenepyruvate hydratase-aldolase | False | 5 | 118 | 1 | 6 | (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = salicylaldehyde + pyruvate | (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase | None | 2'-hydroxybenzalpyruvate aldolase; NsaE; tHBPA hydratase-aldolase | |
| 5.99.1.4 | 2-hydroxychromene-2-carboxylate isomerase | False | 3 | 11669 | 0 | 5 | 2-hydroxy-2H-chromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate | 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase | None | HCCA isomerase; 2HC2CA isomerase; 2-hydroxychromene-2-carboxylic acid isomerase | |
| 6.3.2.31 | coenzyme F420-0:L-glutamate ligase | False | 29 | 5815 | 6 | 3 | GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1 | L-glutamate:coenzyme F420-0 ligase (GDP-forming) | None | CofE-AF; MJ0768; CofE | |
| 6.3.2.32 | coenzyme gamma-F420-2:alpha-L-glutamate ligase | False | 2 | 65 | 0 | 1 | ATP + coenzyme gamma-F420-2 + L-glutamate = ADP + phosphate + coenzyme alpha-F420-3 | L-glutamate:coenzyme gamma-F420-2 (ADP-forming) | None | MJ1001; CofF protein; gamma-F420-2:alpha-L-glutamate ligase | |
| 6.3.2.33 | tetrahydrosarcinapterin synthase | False | 4 | 76 | 0 | 1 | ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin | tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming) | None | H4MPT:alpha-L-glutamate ligase; MJ0620; MptN protein | |
| 6.3.2.34 | coenzyme F420-1:gamma-L-glutamate ligase | False | 29 | 2202 | 0 | 3 | GTP + coenzyme F420-1 + L-glutamate = GDP + phosphate + coenzyme gamma-F420-2 | L-glutamate:coenzyme F420-1 ligase (GDP-forming) | None | F420:gamma-glutamyl ligase; CofE-AF; MJ0768; CofE | |
| 1.14.13.114 | 6-hydroxynicotinate 3-monooxygenase | False | 3 | 416 | 1 | 4 | 6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 | 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating) | None | NicC; 6HNA monooxygenase; HNA-3-monooxygenase | |
| 3.5.1.104 | peptidoglycan-N-acetylglucosamine deacetylase | False | 8 | 9551 | 0 | 10 | peptidoglycan-N-acetyl-D-glucosamine + H2O = peptidoglycan-D-glucosamine + acetate | peptidoglycan-N-acetylglucosamine amidohydrolase | None | HP310; PgdA; SpPgdA; BC1960; peptidoglycan deacetylase; N-acetylglucosamine deacetylase; peptidoglycan GlcNAc deacetylase; peptidoglycan N-acetylglucosamine deacetylase; PG N-deacetylase | |
| 3.5.1.105 | chitin disaccharide deacetylase | False | 56 | 1197 | 1 | 13 | N,N'-diacetylchitobiose + H2O = N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine + acetate | N,N'-diacetylchitobiose acetylhydrolase | None | chitobiose amidohydolase; COD; chitin oligosaccharide deacetylase; chitin oligosaccharide amidohydolase; 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-D-glucopyranose acetylhydrolase | |
| 3.5.1.106 | N-formylmaleamate deformylase | False | 1 | 150 | 0 | 1 | N-formylmaleamic acid + H2O = maleamate + formate | N-formylmaleamic acid amidohydrolase | None | NicD | |
| 3.5.1.107 | maleamate amidohydrolase | False | 1 | 322 | 2 | 3 | maleamate + H2O = maleate + NH3 | maleamate amidohydrolase | None | NicF | |
| 1.1.1.305 | UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) | False | 75 | 1988 | 0 | 3 | UDP-alpha-D-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+ | UDP-alpha-D-glucuronate:NAD+ oxidoreductase (decarboxylating) | None | UDP-GlcUA decarboxylase; ArnADH; UDP-glucuronate:NAD+ oxidoreductase (decarboxylating) | |
| 1.1.1.306 | S-(hydroxymethyl)mycothiol dehydrogenase | False | 1 | 2262 | 0 | 4 | S-(hydroxymethyl)mycothiol + NAD+ = S-formylmycothiol + NADH + H+ | S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase | None | NAD/factor-dependent formaldehyde dehydrogenase; mycothiol-dependent formaldehyde dehydrogenase | |
| 1.1.2.6 | polyvinyl alcohol dehydrogenase (cytochrome) | False | 2 | 107 | 0 | 2 | polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+ | polyvinyl alcohol:ferricytochrome-c oxidoreductase | None | PVA dehydrogenase; PVADH | |
| 1.1.2.7 | methanol dehydrogenase (cytochrome c) | False | 8 | 464 | 10 | 18 | a primary alcohol + 2 ferricytochrome cL = an aldehyde + 2 ferrocytochrome cL + 2 H+ | methanol:cytochrome c oxidoreductase | None | methanol dehydrogenase; MDH (ambiguous) | |
| 1.1.2.8 | alcohol dehydrogenase (cytochrome c) | False | 3 | 541 | 4 | 10 | a primary alcohol + 2 ferricytochrome c = an aldehyde + 2 ferrocytochrome c + 2 H+ | alcohol:cytochrome c oxidoreductase | None | type I quinoprotein alcohol dehydrogenase; quinoprotein ethanol dehydrogenase | |
| 1.1.99.35 | soluble quinoprotein glucose dehydrogenase | False | 1 | 17 | 0 | 4 | D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor | D-glucose:acceptor oxidoreductase | None | soluble glucose dehydrogenase; sGDH; glucose dehydrogenase (PQQ-dependent) | |
| 1.2.5.1 | pyruvate dehydrogenase (quinone) | False | 1 | 4388 | 3 | 6 | pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol | pyruvate:ubiquinone oxidoreductase | None | pyruvate dehydrogenase (ambiguous); pyruvic dehydrogenase (ambiguous); pyruvic (cytochrome b1) dehydrogenase (incorrect); pyruvate:ubiquinone-8-oxidoreductase; pyruvate oxidase (ambiguous); pyruvate dehydrogenase (cytochrome) (incorrect) | |
| 1.3.5.3 | protoporphyrinogen IX dehydrogenase (quinone) | False | 5 | 2735 | 0 | 1 | protoporphyrinogen IX + 3 quinone = protoporphyrin IX + 3 quinol | protoporphyrinogen IX:quinone oxidoreductase | None | HemG; protoporphyrinogen IX dehydrogenase (menaquinone) | |
| 1.8.7.2 | ferredoxin:thioredoxin reductase | False | 11 | 3577 | 4 | 10 | 2 reduced ferredoxin + thioredoxin disulfide + 2 H+ = 2 oxidized ferredoxin + thioredoxin | ferredoxin:thioredoxin disulfide oxidoreductase | None | None | |
| 1.11.1.18 | bromide peroxidase | False | 3 | 412 | 7 | 22 | RH + HBr + H2O2 = RBr + 2 H2O | bromide:hydrogen-peroxide oxidoreductase | None | bromoperoxidase; haloperoxidase (ambiguous); eosinophil peroxidase | |
| 1.14.11.29 | hypoxia-inducible factor-proline dioxygenase | False | 12 | 2724 | 41 | 7 | hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) | None | HIF hydroxylase | |
| 1.14.11.30 | hypoxia-inducible factor-asparagine dioxygenase | False | 3 | 9 | 32 | 1 | hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 | hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) | None | HIF hydroxylase | |
| 1.14.11.31 | thebaine 6-O-demethylase | False | 2 | 33 | 2 | 2 | thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + CO2 | thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating) | None | T6ODM | |
| 1.14.11.32 | codeine 3-O-demethylase | False | 1 | 101 | 0 | 2 | codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2 | codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating) | None | codeine O-demethylase; CODM | |
| 1.17.2.1 | nicotinate dehydrogenase (cytochrome) | False | 2 | 590 | 0 | 1 | nicotinate + a ferricytochrome + H2O = 6-hydroxynicotinate + a ferrocytochrome + 2 H+ | nicotinate:cytochrome 6-oxidoreductase (hydroxylating) | None | nicotinic acid hydroxylase; nicotinate hydroxylase | |
| 2.1.1.166 | 23S rRNA (uridine2552-2'-O)-methyltransferase | False | 407 | 16625 | 0 | 3 | S-adenosyl-L-methionine + uridine2552 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase | None | Um(2552) 23S ribosomal RNA methyltransferase; heat shock protein RrmJ; RrmJ; FTSJ; Um2552 methyltransferase | |
| 2.1.2.13 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase | False | 75 | 1980 | 3 | 2 | 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose | 10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase | None | UDP-L-Ara4N formyltransferase; ArnAFT | |
| 2.3.1.191 | UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase | False | 330 | 24718 | 12 | 11 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein] | (3R)-3-hydroxyacyl-[acyl-carrier protein]:UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine N-acyltransferase | None | lpxD (gene name); UDP-3-O-acyl-glucosamine N-acyltransferase; UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; acyltransferase LpxD; acyl-ACP:UDP-3-O-(3-hydroxyacyl)-GlcN N-acyltransferase; firA (gene name); (3R)-3-hydroxymyristoyl-[acyl-carrier protein]:UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine N-acetyltransferase; UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein]:UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine N-acetyltransferase | |
| 2.3.1.304 | poly[(R)-3-hydroxyalkanoate] polymerase | True | 0 | 0 | 0 | 48 | (3R)-3-hydroxyacyl-CoA + poly[(R)-3-hydroxyalkanoate]n = CoA + poly[(R)-3-hydroxyalkanoate]n+1 | poly(R)-3-hydroxyalkanoate (3R)-3-hydroxyacyltransferase | None | PHA synthase; phaC (gene name); PhaE | |
| 2.3.2.16 | lipid II:glycine glycyltransferase | False | 14 | 777 | 1 | 2 | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + tRNAGly | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc:glycine N6-glycyltransferase | None | N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:N6-glycine transferase; femX (gene name); alanyl-D-alanine-diphospho-ditrans,octacis-undecaprenyl-N-acetylglucosamine:glycine N6-glycyltransferase | |
| 2.3.2.17 | N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | False | 12 | 1041 | 0 | 4 | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNAGly | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc:glycine glycyltransferase | None | femA (gene name); N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | |
| 2.3.2.18 | N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | False | 12 | 80 | 0 | 3 | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-penta-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNAGly | MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc:glycine glycyltransferase | None | femB (gene name); N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | |
| 2.4.99.12 | lipid IVA 3-deoxy-D-manno-octulosonic acid transferase | False | 18 | 24960 | 0 | 9 | CMP-beta-Kdo + a lipid IVA + CMP-beta-Kdo = CMP + an alpha-Kdo-(2->6)-[lipid IVA] | CMP-3-deoxy-beta-D-manno-oct-2-ulosonate:[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting) | None | waaA (gene name); kdtA (gene name); 3-deoxy-D-manno-oct-2-ulosonic acid transferase; 3-deoxy-manno-octulosonic acid transferase; lipid IVA KDO transferase; CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase; KDO transferase | |
| 2.7.7.79 | tRNAHis guanylyltransferase | False | 15 | 4550 | 3 | 15 | p-tRNAHis + ATP + GTP + H2O = pGp-tRNAHis + AMP + 2 diphosphate (overall reaction);;(1a) p-tRNAHis + ATP = App-tRNAHis + diphosphate;;(1b) App-tRNAHis + GTP = pppGp-tRNAHis + AMP;;(1c) pppGp-tRNAHis + H2O = pGp-tRNAHis + diphosphate | p-tRNAHis:GTP guanylyltransferase (ATP-hydrolysing) | None | histidine tRNA guanylyltransferase; Thg1p (ambiguous); Thg1 (ambiguous) | |
| 2.4.99.13 | (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase | False | 10 | 139 | 0 | 5 | CMP-beta-Kdo + an alpha-Kdo-(2->6)-[lipid IVA] = CMP + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] | CMP-3-deoxy-beta-D-manno-oct-2-ulosonate:alpha-Kdo-(2->6)-[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting) | None | waaA (gene name); kdtA (gene name); 3-deoxy-D-manno-oct-2-ulosonic acid transferase; 3-deoxy-manno-octulosonic acid transferase; (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase; CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase; Kdo transferase (ambiguous) | |
| 2.5.1.154 | corrinoid adenosyltransferase EutT | False | 3 | 0 | 0 | 2 | 2 ATP + 2 cob(II)alamin + a reduced flavoprotein = 2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein (overall reaction);;(1a) 2 cob(II)alamin + 2 [corrinoid adenosyltransferase] = 2 [corrinoid adenosyltransferase]-cob(II)alamin;;(1b) a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)alamin = an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)alamin (spontaneous);;(1c) 2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)alamin = 2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + 2 [corrinoid adenosyltransferase] | ATP:cob(II)alamin Cobeta-adenosyltransferase (diphosphate-forming) | None | eutT (gene name) | |
| 2.7.7.78 | GDP-D-glucose phosphorylase | False | 8 | 1782 | 0 | 3 | GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP | GDP:alpha-D-glucose 1-phosphate guanylyltransferase | None | None | |
| 2.4.99.14 | (Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase | False | 6 | 118 | 0 | 3 | alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP | CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase [(2->8) glycosidic bond-forming] | None | Kdo transferase; waaA (gene name); kdtA (gene name); 3-deoxy-D-manno-oct-2-ulosonic acid transferase; 3-deoxy-manno-octulosonic acid transferase; (KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase | |
| 2.4.99.15 | (Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase | False | 3 | 521 | 0 | 1 | alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP | CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)3-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase [(2->4) glycosidic bond-forming] | None | Kdo transferase; waaA (gene name); kdtA (gene name); 3-deoxy-D-manno-oct-2-ulosonic acid transferase; 3-deoxy-manno-octulosonic acid transferase; (KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase | |
| 2.6.1.87 | UDP-4-amino-4-deoxy-L-arabinose aminotransferase | False | 71 | 3377 | 2 | 2 | UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate | UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase | None | UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase; UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase; UDP-Ara4O aminotransferase; UDP-L-Ara4N transaminase | |
| 2.7.1.166 | 3-deoxy-D-manno-octulosonic acid kinase | False | 27 | 2453 | 0 | 2 | alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP | ATP:(Kdo)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase | None | kdkA (gene name); Kdo kinase | |
| 2.7.1.167 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | False | 200 | 8022 | 4 | 4 | D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP | ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase | None | heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose-7-phosphate kinase; HldE1 heptokinase; glycero-manno-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase; hldE (gene name); rfaE (gene name) | |
| 2.7.1.168 | D-glycero-alpha-D-manno-heptose-7-phosphate kinase | False | 3 | 264 | 0 | 1 | D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP | ATP:D-glycero-alpha-D-manno-heptose 7-phosphate 1-phosphotransferase | None | D-alpha-D-heptose-7-phosphate kinase; hdda (gene name) | |
| 2.7.7.70 | D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase | False | 200 | 14726 | 0 | 4 | D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate | ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase | None | D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase; D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase; hldE (gene name); rfaE (gene name) | |
| 2.7.7.71 | D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase | False | 2 | 549 | 0 | 3 | D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate | GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase | None | hddC (gene name); gmhD (gene name) | |
| 3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | False | 21 | 164 | 0 | 11 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase | None | gmhB (gene name); yaeD (gene name) | |
| 3.1.3.83 | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphatase | False | 9 | 30 | 0 | 2 | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase | None | gmhB (gene name) | |
| 3.5.1.108 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | False | 322 | 24203 | 52 | 7 | a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate | UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine amidohydrolase | None | LpxC protein; LpxC enzyme; LpxC deacetylase; deacetylase LpxC; UDP-3-O-acyl-GlcNAc deacetylase; UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase; UDP-(3-O-acyl)-N-acetylglucosamine deacetylase; UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase; UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase; UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase | |
| 3.6.1.54 | UDP-2,3-diacylglucosamine diphosphatase | False | 163 | 10698 | 15 | 7 | a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + UMP | UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine-1-phosphate phosphohydrolase | None | lpxH (gene name); UDP-2,3-diacylglucosamine hydrolase; UDP-2,3-diacylglucosamine pyrophosphatase; ybbF (gene name); UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate phosphohydrolase (incorrect); UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate phosphohydrolase | |
| 4.2.3.46 | alpha-farnesene synthase | False | 13 | 26 | 0 | 7 | (2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate | (2E,6E)-farnesyl-diphosphate lyase [(3E,6E)-alpha-farnesene-forming] | None | (E,E)-alpha-farnesene synthase; AFS1; MdAFS1 | |
| 4.2.3.47 | beta-farnesene synthase | False | 24 | 26 | 0 | 10 | (2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-beta-farnesene-forming] | None | farnesene synthase; terpene synthase 10; terpene synthase 10-B73; TPS10 | |
| 5.3.1.28 | D-sedoheptulose-7-phosphate isomerase | False | 208 | 13268 | 6 | 15 | D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate | D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase | None | sedoheptulose-7-phosphate isomerase; phosphoheptose isomerase; gmhA (gene name); lpcA (gene name) | |
| 2.1.1.168 | 21S rRNA (uridine2791-2'-O)-methyltransferase | False | 1 | 1 | 0 | 1 | S-adenosyl-L-methionine + uridine2791 in 21S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA | S-adenosyl-L-methionine:21S rRNA (uridine2791-2'-O-)-methyltransferase | None | MRM2 (gene name); mitochondrial 21S rRNA methyltransferase; mitochondrial rRNA MTase 2 | |
| 2.1.1.169 | tricetin 3',4',5'-O-trimethyltransferase | False | 1 | 0 | 0 | 1 | 3 S-adenosyl-L-methionine + tricetin = 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin (overall reaction);;(1a) S-adenosyl-L-methionine + tricetin = S-adenosyl-L-homocysteine + 3'-O-methyltricetin;;(1b) S-adenosyl-L-methionine + 3'-O-methyltricetin = S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin;;(1c) S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin = S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin | S-adenosyl-L-methionine:tricetin 3',4',5'-O-trimethyltransferase | None | FOMT; TaOMT1; TaCOMT1; TaOMT2 | |
| 2.1.1.170 | 16S rRNA (guanine527-N7)-methyltransferase | False | 368 | 13305 | 0 | 5 | S-adenosyl-L-methionine + guanine527 in 16S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (guanine527-N7)-methyltransferase | None | ribosomal RNA small subunit methyltransferase G; 16S rRNA methyltransferase RsmG; GidB; rsmG (gene name) | |
| 2.1.1.171 | 16S rRNA (guanine966-N2)-methyltransferase | False | 6 | 20325 | 1 | 2 | S-adenosyl-L-methionine + guanine966 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine966 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase | None | yhhF (gene name); rsmD (gene name); m2G966 methyltransferase | |
| 2.1.1.172 | 16S rRNA (guanine1207-N2)-methyltransferase | False | 140 | 5008 | 0 | 1 | S-adenosyl-L-methionine + guanine1207 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase | None | m2G1207 methyltransferase | |
| 2.1.1.173 | 23S rRNA (guanine2445-N2)-methyltransferase | False | 166 | 7032 | 2 | 2 | S-adenosyl-L-methionine + guanine2445 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase | None | ycbY (gene name); rlmL (gene name) | |
| 2.1.1.174 | 23S rRNA (guanine1835-N2)-methyltransferase | False | 106 | 4067 | 1 | 1 | S-adenosyl-L-methionine + guanine1835 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase | None | ygjO (gene name); rlmG (gene name); ribosomal RNA large subunit methyltransferase G | |
| 2.4.2.43 | lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase | False | 79 | 3272 | 1 | 5 | (1) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,octacis-undecaprenyl phosphate;; (2) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + lipid IVA = lipid IIA + ditrans,octacis-undecaprenyl phosphate;; (3) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = 4'-alpha-L-Ara4N-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + ditrans,octacis-undecaprenyl phosphate | 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl-phosphate:lipid IVA 4-amino-4-deoxy-L-arabinopyranosyltransferase | None | undecaprenyl phosphate-alpha-L-Ara4N transferase; 4-amino-4-deoxy-L-arabinose lipid A transferase; polymyxin resistance protein PmrK; arnT (gene name) | |
| 2.7.8.29 | L-serine-phosphatidylethanolamine phosphatidyltransferase | False | 16 | 3468 | 0 | 6 | L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine | L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase | None | phosphatidylserine synthase 2; serine-exchange enzyme II; PTDSS2 (gene name) | |
| 3.1.7.6 | farnesyl diphosphatase | False | 3 | 3 | 0 | 7 | (2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphohydrolase | None | FPP phosphatase | |
| 4.2.3.48 | (3S,6E)-nerolidol synthase | False | 5 | 13 | 0 | 8 | (2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming] | None | (E)-nerolidol synthase; nerolidol synthase; (3S)-(E)-nerolidol synthase; FaNES1 | |
| 4.2.3.49 | (3R,6E)-nerolidol synthase | False | 1 | 1 | 0 | 4 | (2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3R,6E)-nerolidol-forming] | None | terpene synthase 1 | |
| 6.3.1.14 | diphthine---ammonia ligase | False | 7 | 6981 | 0 | 2 | ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2] | diphthine-[translation elongation factor 2]:ammonia ligase (AMP-forming) | None | diphthamide synthase; diphthamide synthetase; DPH6 (gene name); ATPBD4 (gene name); diphthine:ammonia ligase (AMP-forming) | |
| 2.7.7.69 | GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase | False | 2 | 22 | 0 | 7 | (1) GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose;;(2) GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose | GDP-beta-L-galactose/GDP-alpha-D-glucose:hexose 1-phosphate guanylyltransferase | None | VTC2; VTC5; GDP-L-galactose phosphorylase | |
| 1.1.1.307 | D-xylose reductase [NAD(P)H] | False | 22 | 3231 | 2 | 30 | xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ | xylitol:NAD(P)+ oxidoreductase | None | XylR; msXR; dsXR; dual specific xylose reductase; NAD(P)H-dependent xylose reductase; xylose reductase (ambiguous); D-xylose reductase (ambiguous) | |
| 1.1.99.36 | alcohol dehydrogenase (nicotinoprotein) | False | 2 | 541 | 0 | 2 | ethanol + acceptor = acetaldehyde + reduced acceptor | ethanol:acceptor oxidoreductase | None | NDMA-dependent alcohol dehydrogenase; nicotinoprotein alcohol dehydrogenase; np-ADH; ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase | |
| 1.1.99.37 | methanol dehydrogenase (nicotinoprotein) | False | 3 | 129 | 0 | 4 | methanol + acceptor = formaldehyde + reduced acceptor | methanol:acceptor oxidoreductase | None | NDMA-dependent methanol dehydrogenase; nicotinoprotein methanol dehydrogenase; methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase | |
| 1.14.14.8 | anthranilate 3-monooxygenase (FAD) | False | 1 | 63 | 0 | 1 | anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O | anthranilate,FADH2:oxygen oxidoreductase (3-hydroxylating) | None | anthranilate 3-hydroxylase; anthranilate hydroxylase | |
| 2.1.1.175 | tricin synthase | False | 3 | 0 | 0 | 3 | 2 S-adenosyl-L-methionine + tricetin = 2 S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin (overall reaction);;(1a) S-adenosyl-L-methionine + tricetin = S-adenosyl-L-homocysteine + 3'-O-methyltricetin;;(1b) S-adenosyl-L-methionine + 3'-O-methyltricetin = S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin | S-adenosyl-L-methionine:tricetin 3',5'-O-dimethyltransferase | None | ROMT-17; ROMT-15; HvOMT1; ZmOMT1 | |
| 2.1.1.176 | 16S rRNA (cytosine967-C5)-methyltransferase | False | 84 | 19684 | 0 | 3 | S-adenosyl-L-methionine + cytosine967 in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine967 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (cytosine967-C5)-methyltransferase | None | rsmB (gene name); fmu (gene name); 16S rRNA m5C967 methyltransferase | |
| 2.1.1.177 | 23S rRNA (pseudouridine1915-N3)-methyltransferase | False | 618 | 26084 | 7 | 1 | S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (pseudouridine1915-N3)-methyltransferase | None | YbeA; RlmH; pseudouridine methyltransferase; m3Psi methyltransferase; Psi1915-specific methyltransferase; rRNA large subunit methyltransferase H | |
| 2.1.1.178 | 16S rRNA (cytosine1407-C5)-methyltransferase | False | 87 | 2568 | 0 | 2 | S-adenosyl-L-methionine + cytosine1407 in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (cytosine1407-C5)-methyltransferase | None | RNA m5C methyltransferase YebU; RsmF; YebU | |
| 2.1.1.179 | 16S rRNA (guanine1405-N7)-methyltransferase | False | 7 | 534 | 5 | 16 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (guanine1405-N7)-methyltransferase | None | methyltransferase Sgm; m7G1405 Mtase; Sgm Mtase; Sgm; sisomicin-gentamicin methyltransferase; sisomicin-gentamicin methylase; GrmA; RmtB; RmtC; ArmA | |
| 2.1.1.180 | 16S rRNA (adenine1408-N1)-methyltransferase | False | 3 | 12 | 1 | 9 | S-adenosyl-L-methionine + adenine1408 in 16S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase | None | kanamycin-apramycin resistance methylase; 16S rRNA:m1A1408 methyltransferase; KamB; NpmA; 16S rRNA m1A1408 methyltransferase | |
| 2.1.1.181 | 23S rRNA (adenine1618-N6)-methyltransferase | False | 124 | 4901 | 0 | 1 | S-adenosyl-L-methionine + adenine1618 in 23S rRNA = S-adenosyl-L-homocysteine + N6-methyladenine1618 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (adenine1618-N6)-methyltransferase | None | rRNA large subunit methyltransferase F; YbiN protein; rlmF (gene name); m6A1618 methyltransferase | |
| 2.1.1.182 | 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase | False | 624 | 39548 | 31 | 9 | 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase | None | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; KsgA; ksgA methyltransferase | |
| 2.1.1.183 | 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase | False | 15 | 15 | 6 | 2 | 4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA | S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase | None | 18S rRNA dimethylase Dim1p; Dim1p; ScDim1; m2(6)A dimethylase; KIDIM1 | |
| 2.1.1.184 | 23S rRNA (adenine2085-N6)-dimethyltransferase | False | 18 | 676 | 1 | 2 | 2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (adenine2085-N6)-dimethyltransferase | None | ErmC' methyltransferase; ermC methylase; ermC 23S rRNA methyltransferase; rRNA:m6A methyltransferase ErmC'; ErmC'; rRNA methyltransferase ErmC' | |
| 2.1.1.185 | 23S rRNA (guanosine2251-2'-O)-methyltransferase | False | 37 | 9051 | 0 | 1 | S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O-)-methyltransferase | None | rlmB (gene name); yifH (gene name) | |
| 2.1.1.186 | 23S rRNA (cytidine2498-2'-O)-methyltransferase | False | 170 | 4158 | 3 | 1 | S-adenosyl-L-methionine + cytidine2498 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (cytidine2498-2'-O-)-methyltransferase | None | YgdE; rRNA large subunit methyltransferase M; RlmM | |
| 2.5.1.81 | geranylfarnesyl diphosphate synthase | False | 17 | 89 | 0 | 5 | geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate | geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit) | None | FGPP synthase; (all-E) geranylfarnesyl diphosphate synthase; GFPS; Fgs | |
| 2.5.1.82 | hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | False | 1 | 4 | 0 | 1 | geranylgeranyl diphosphate + 2 (3-methylbut-3-en-1-yl diphosphate) = 2 diphosphate + all-trans-hexaprenyl diphosphate | geranylgeranyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 2 units of 3-methylbut-3-en-1-yl) | None | HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous); geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units) | |
| 2.5.1.83 | hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | False | 2 | 61 | 0 | 2 | (2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate | (2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl) | None | HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous); (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units) | |
| 2.5.1.84 | all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific] | False | 4 | 307 | 0 | 3 | geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate | geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units) | None | nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphate synthase (ambiguous); OsSPS2 | |
| 2.5.1.85 | all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | False | 4 | 48 | 0 | 5 | geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate | geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units) | None | nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2 | |
| 2.5.1.86 | trans,polycis-decaprenyl diphosphate synthase | False | 5 | 5 | 2 | 8 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate | (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units) | None | Rv2361c; (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase | |
| 2.5.1.87 | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] | False | 18 | 4196 | 7 | 12 | (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10--55) | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10--55 isopentenyl units) | None | RER2; Rer2p; Rer2p Z-prenyltransferase; Srt1p; Srt2p Z-prenyltransferase; ACPT; dehydrodolichyl diphosphate synthase 1 | |
| 2.5.1.88 | trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific] | False | 1 | 8 | 2 | 1 | (2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) | (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units) | None | None | |
| 2.5.1.89 | tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | False | 20 | 2860 | 0 | 2 | geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate | geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units) | None | None | |
| 6.3.2.35 | D-alanine---D-serine ligase | False | 0 | 3 | 0 | 5 | D-alanine + D-serine + ATP = D-alanyl-D-serine + ADP + phosphate | D-alanine:D-serine ligase (ADP-forming) | None | VanC; VanE; VanG | |
| 1.2.1.79 | succinate-semialdehyde dehydrogenase (NADP+) | False | 20 | 4999 | 2 | 14 | succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+ | succinate-semialdehyde:NADP+ oxidoreductase | None | succinic semialdehyde dehydrogenase (NADP+); succinyl semialdehyde dehydrogenase (NADP+); succinate semialdehyde:NADP+ oxidoreductase; NADP-dependent succinate-semialdehyde dehydrogenase; GabD | |
| 2.1.1.187 | 23S rRNA (guanine745-N1)-methyltransferase | False | 1 | 1941 | 0 | 11 | S-adenosyl-L-methionine + guanine745 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine745-N1)-methyltransferase | None | Rlma(I); Rlma1; 23S rRNA m1G745 methyltransferase; YebH; RlmAI methyltransferase; ribosomal RNA(m1G)-methylase (ambiguous); rRNA(m1G)methylase (ambiguous); RrmA (ambiguous); 23S rRNA:m1G745 methyltransferase | |
| 2.1.1.188 | 23S rRNA (guanine748-N1)-methyltransferase | False | 1 | 89 | 0 | 11 | S-adenosyl-L-methionine + guanine748 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine748-N1)-methyltransferase | None | Rlma(II); Rlma2; 23S rRNA m1G748 methyltransferase; RlmaII; Rlma II; tylosin-resistance methyltransferase RlmA(II); TlrB; rRNA large subunit methyltransferase II | |
| 2.1.1.189 | 23S rRNA (uracil747-C5)-methyltransferase | False | 100 | 3466 | 0 | 4 | S-adenosyl-L-methionine + uracil747 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (uracil747-C5)-methyltransferase | None | YbjF; RumB; RNA uridine methyltransferase B | |
| 2.1.1.190 | 23S rRNA (uracil1939-C5)-methyltransferase | False | 163 | 17875 | 0 | 4 | S-adenosyl-L-methionine + uracil1939 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (uracil1939-C5)-methyltransferase | None | RumA; RNA uridine methyltransferase A; YgcA | |
| 2.1.1.191 | 23S rRNA (cytosine1962-C5)-methyltransferase | False | 82 | 3534 | 0 | 1 | S-adenosyl-L-methionine + cytosine1962 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase | None | RlmI; rRNA large subunit methyltransferase I; YccW | |
| 2.1.1.192 | 23S rRNA (adenine2503-C2)-methyltransferase | False | 637 | 35843 | 6 | 6 | (1) 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin;;(2) 2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin | S-adenosyl-L-methionine:23S rRNA (adenine2503-C2)-methyltransferase | None | RlmN; YfgB; Cfr | |
| 2.1.1.193 | 16S rRNA (uracil1498-N3)-methyltransferase | False | 21 | 42838 | 6 | 3 | S-adenosyl-L-methionine + uracil1498 in 16S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil1498 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (uracil1498-N3)-methyltransferase | None | DUF558 protein; YggJ; RsmE; m3U1498 specific methyltransferase | |
| 2.5.1.90 | all-trans-octaprenyl-diphosphate synthase | False | 3 | 3312 | 2 | 8 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units) | None | octaprenyl-diphosphate synthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase | |
| 2.5.1.91 | all-trans-decaprenyl-diphosphate synthase | False | 8 | 62 | 0 | 11 | (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units) | None | decaprenyl-diphosphate synthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase | |
| 2.5.1.92 | (2Z,6Z)-farnesyl diphosphate synthase | False | 2 | 0 | 5 | 5 | prenyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate;;(1a) prenyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate;;(1b) neryl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate | prenyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units) | None | cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase; dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units) | |
| 4.2.3.50 | (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | False | 1 | 0 | 0 | 1 | (2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate | (2Z,6Z)-farnesyl diphosphate lyase [cyclizing; (+)-alpha-santalene-forming] | None | SBS (ambiguous) | |
| 4.2.3.51 | beta-phellandrene synthase (neryl-diphosphate-cyclizing) | False | 1 | 0 | 0 | 2 | neryl diphosphate = beta-phellandrene + diphosphate | neryl-diphosphate diphosphate-lyase [cyclizing; beta-phellandrene-forming] | None | phellandrene synthase 1; PHS1; monoterpene synthase PHS1 | |
| 4.2.3.52 | (4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing) | False | 9 | 0 | 0 | 5 | geranyl diphosphate = (4S)-beta-phellandrene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing; (4S)-beta-phellandrene-forming] | None | phellandrene synthase; (-)-beta-phellandrene synthase; (-)-(4S)-beta-phellandrene synthase | |
| 4.2.3.53 | (+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | False | 1 | 0 | 0 | 1 | (2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate | (2Z,6Z)-farnesyl diphosphate lyase (cyclizing; (+)-endo-beta-bergamotene-forming) | None | SBS (ambiguous) | |
| 4.2.3.54 | (-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | False | 4 | 0 | 0 | 1 | (2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphate | (2Z,6Z)-farnesyl diphosphate lyase [cyclizing; (-)-endo-alpha-bergamotene-forming] | None | SBS (ambiguous) | |
| 6.1.2.1 | D-alanine---(R)-lactate ligase | False | 2 | 35 | 1 | 14 | D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate | D-alanine:(R)-lactate ligase (ADP-forming) | None | VanA; VanB; VanD | |
| 2.5.1.95 | xanthan ketal pyruvate transferase | True | 0 | 0 | 0 | 1 | phosphoenolpyruvate + D-Man-beta-(1->4)-D-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = 4,6-CH3(COO-)C-D-Man-beta-(1->4)-D-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol + phosphate | phosphoenolpyruvate:D-Man-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4,6-O-(1-carboxyethan-1,1-diyl)transferase | None | KPT | |
| 2.7.7.77 | molybdenum cofactor guanylyltransferase | False | 211 | 20731 | 0 | 2 | GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor | GTP:molybdenum cofactor guanylyltransferase | None | MobA; MoCo guanylyltransferase | |
| 2.7.8.33 | UDP-N-acetylglucosamine---undecaprenyl-phosphate N-acetylglucosaminephosphotransferase | False | 11 | 3895 | 0 | 5 | UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-alpha-D-glucosaminephosphotransferase | None | UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; WecA; WecA transferase; UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase; GlcNAc-P-P-Und synthase; GPT (ambiguous); TagO; UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetylglucosaminephosphotransferase | |
| 1.1.5.8 | quinate/shikimate dehydrogenase (quinone) | False | 2 | 426 | 0 | 4 | quinate + quinone = 3-dehydroquinate + quinol | quinate:quinol 3-oxidoreductase | None | NAD(P)+-independent quinate dehydrogenase; quinate:pyrroloquinoline-quinone 5-oxidoreductase; quinate dehydrogenase (quinone) | |
| 1.3.8.10 | cyclohex-1-ene-1-carbonyl-CoA dehydrogenase | False | 2 | 67 | 0 | 2 | cyclohex-1-ene-1-carbonyl-CoA + electron-transfer flavoprotein = cyclohex-1,5-diene-1-carbonyl-CoA + reduced electron-transfer flavoprotein | cyclohex-1-ene-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase | None | None | |
| 1.14.12.22 | carbazole 1,9a-dioxygenase | False | 2 | 30 | 13 | 8 | 9H-carbazole + NAD(P)H + H+ + O2 = 2'-aminobiphenyl-2,3-diol + NAD(P)+ | 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating) | None | CARDO | |
| 1.17.5.2 | caffeine dehydrogenase | False | 3 | 491 | 0 | 1 | caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol | caffeine:ubiquinone oxidoreductase | None | None | |
| 2.1.1.195 | cobalt-precorrin-5B (C1)-methyltransferase | False | 182 | 9713 | 0 | 2 | S-adenosyl-L-methionine + cobalt-precorrin-5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A | S-adenosyl-L-methionine:cobalt-precorrin-5B C1-methyltransferase | None | cobalt-precorrin-6A synthase; CbiD | |
| 2.1.1.196 | cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating] | False | 28 | 707 | 0 | 3 | S-adenosyl-L-methionine + cobalt-precorrin-6B = S-adenosyl-L-homocysteine + cobalt-precorrin-7 + CO2 | S-adenosyl-L-methionine:precorrin-6B C15-methyltransferase (C-12-decarboxylating) | None | cbiT (gene name); S-adenosyl-L-methionine:precorrin-7 C15-methyltransferase (C-12-decarboxylating); cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating] | |
| 2.1.1.197 | malonyl-[acyl-carrier protein] O-methyltransferase | False | 58 | 9130 | 0 | 3 | S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester | S-adenosyl-L-methionine:malonyl-[acyl-carrier protein] O-methyltransferase | None | BioC | |
| 2.1.1.198 | 16S rRNA (cytidine1402-2'-O)-methyltransferase | False | 42 | 39178 | 1 | 1 | S-adenosyl-L-methionine + cytidine1402 in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (cytidine1402-2'-O)-methyltransferase | None | RsmI; YraL | |
| 2.1.1.199 | 16S rRNA (cytosine1402-N4)-methyltransferase | False | 840 | 42689 | 1 | 1 | S-adenosyl-L-methionine + cytosine1402 in 16S rRNA = S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (cytosine1402-N4)-methyltransferase | None | RsmH; MraW | |
| 2.3.1.192 | glycine N-phenylacetyltransferase | False | 1 | 0 | 0 | 2 | phenylacetyl-CoA + glycine = CoA + phenylacetylglycine | phenylacetyl-CoA:glycine N-phenylacetyltransferase | None | arylacetyl-CoA N-acyltransferase; arylacetyltransferase; GAT (gene name) | |
| 2.5.1.93 | 4-hydroxybenzoate geranyltransferase | False | 2 | 1 | 0 | 2 | geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate | geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase | None | PGT1; PGT2; 4HB geranyltransferase; 4HB:geranyltransferase; p-hydroxybenzoate geranyltransferase; PHB geranyltransferase; geranyl diphosphate:4-hydroxybenzoate geranyltransferase | |
| 2.8.2.35 | dermatan 4-sulfotransferase | False | 2 | 0 | 0 | 4 | 3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine | 3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfonotransferase | None | dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase; dermatan-4-sulfotransferase-1; dermatan-4-sulfotransferase 1; D4ST-1; dermatan N-acetylgalactosamine 4-O-sulfotransferase; CHST14 protein; CHST14; 3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase | |
| 3.1.2.28 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | False | 34 | 1981 | 1 | 3 | 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | None | menI (gene name); ydiL (gene name) | |
| 3.2.1.166 | heparanase | False | 5 | 998 | 14 | 11 | endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan | heparan sulfate N-sulfo-D-glucosamine endoglucanase | None | Hpa1 heparanase; Hpa1; heparanase 1; heparanase-1; C1A heparanase; HPSE | |
| 3.7.1.12 | cobalt-precorrin 5A hydrolase | False | 3 | 1412 | 0 | 2 | cobalt-precorrin-5A + H2O = cobalt-precorrin-5B + acetaldehyde + 2 H+ | cobalt-precorrin 5A acylhydrolase | None | CbiG | |
| 3.7.1.13 | 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase | False | 1 | 154 | 0 | 3 | (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = anthranilate + (2E)-2-hydroxypenta-2,4-dienoate | (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase | None | CarC | |
| 1.1.1.308 | sulfopropanediol 3-dehydrogenase | False | 2 | 707 | 0 | 1 | (R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O = (R)-3-sulfolactate + 2 NADH + 2 H+ | (R)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase | None | DHPS 3-dehydrogenase (sulfolactate forming); 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming); dihydroxypropanesulfonate 3-dehydrogenase; hpsN (gene name) | |
| 1.1.1.309 | phosphonoacetaldehyde reductase (NADH) | False | 1 | 16 | 0 | 1 | 2-hydroxyethylphosphonate + NAD+ = phosphonoacetaldehyde + NADH + H+ | 2-hydroxyethylphosphonate:NAD+ oxidoreductase | None | PhpC | |
| 1.2.1.80 | long-chain acyl-[acyl-carrier-protein] reductase | False | 2 | 683 | 4 | 7 | a long-chain aldehyde + an [acyl-carrier protein] + NAD(P)+ = a long-chain acyl-[acyl-carrier protein] + NAD(P)H + H+ | long-chain-aldehyde:NAD(P)+ oxidoreductase (acyl-[acyl-carrier protein]-forming) | None | long-chain acyl-[acp] reductase; fatty acyl-[acyl-carrier-protein] reductase; acyl-[acp] reductase | |
| 1.3.1.85 | crotonyl-CoA carboxylase/reductase | False | 1 | 2108 | 0 | 9 | (2S)-ethylmalonyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + CO2 + NADPH + H+ | (2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating) | None | CCR; crotonyl-CoA reductase (carboxylating) | |
| 1.3.1.86 | crotonyl-CoA reductase | False | 3 | 476 | 0 | 6 | butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ | butanoyl-CoA:NADP+ 2,3-oxidoreductase | None | butyryl-CoA dehydrogenase; butyryl dehydrogenase; unsaturated acyl-CoA reductase; ethylene reductase; enoyl-coenzyme A reductase; unsaturated acyl coenzyme A reductase; butyryl coenzyme A dehydrogenase; short-chain acyl CoA dehydrogenase; short-chain acyl-coenzyme A dehydrogenase; 3-hydroxyacyl CoA reductase; butanoyl-CoA:(acceptor) 2,3-oxidoreductase; CCR | |
| 1.11.1.19 | dye decolorizing peroxidase | False | 6 | 250 | 24 | 28 | Reactive Blue 5 + 2 H2O2 = phthalate + 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H2O | Reactive-Blue-5:hydrogen-peroxide oxidoreductase | None | DyP; DyP-type peroxidase | |
| 1.11.2.1 | unspecific peroxygenase | False | 1 | 278 | 32 | 6 | RH + H2O2 = ROH + H2O | substrate:hydrogen-peroxide oxidoreductase (RH-hydroxylating or -epoxidising) | None | aromatic peroxygenase; mushroom peroxygenase; haloperoxidase-peroxygenase; Agrocybe aegerita peroxidase | |
| 2.4.1.251 | GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase | False | 2 | 65 | 0 | 2 | GDP-mannose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-beta-(1->4)- GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol | GDP-mannose:GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase | None | GumI | |
| 2.4.1.252 | GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase | False | 3 | 104 | 0 | 4 | GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol | GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase | None | GumH; AceA; alpha1,3-mannosyltransferase AceA | |
| 2.4.1.253 | baicalein 7-O-glucuronosyltransferase | False | 1 | 0 | 0 | 1 | UDP-D-glucuronate + baicalein = UDP + baicalin | UDP-D-glucuronate:5,6,7-trihydroxyflavone 7-O-glucuronosyltransferase | None | UBGAT | |
| 2.5.1.94 | adenosyl-chloride synthase | False | 3 | 248 | 2 | 6 | S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine | S-adenosyl-L-methionine:chloride adenosyltransferase | None | chlorinase; 5'-chloro-5'-deoxyadenosine synthase | |
| 2.7.1.169 | pantoate kinase | False | 3 | 2159 | 2 | 2 | ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate | ATP:(R)-pantoate 4-phosphotransferase | None | PoK; TK2141 protein | |
| 2.7.4.25 | (d)CMP kinase | False | 567 | 41888 | 6 | 6 | ATP + (d)CMP = ADP + (d)CDP | ATP:(d)CMP phosphotransferase | None | cmk (gene name); prokaryotic cytidylate kinase; deoxycytidylate kinase (misleading); dCMP kinase (misleading); deoxycytidine monophosphokinase (misleading) | |
| 2.7.8.31 | undecaprenyl-phosphate glucose phosphotransferase | False | 5 | 6546 | 0 | 6 | UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol | UDP-glucose:ditrans,octacis-undecaprenyl-phosphate glucose phosphotransferase | None | GumD; undecaprenylphosphate glucosylphosphate transferase | |
| 3.2.1.167 | baicalin-beta-D-glucuronidase | False | 1 | 0 | 0 | 6 | baicalin + H2O = baicalein + D-glucuronate | 5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase | None | baicalinase | |
| 3.2.1.168 | hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase | True | 0 | 0 | 0 | 3 | hesperidin + H2O = hesperetin + rutinose | hesperetin 7-(6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside) 6-O-alpha-rhamnopyranosyl-beta-glucohydrolase | None | AnRut; rutinosidase | |
| 3.5.2.19 | streptothricin hydrolase | False | 2 | 489 | 0 | 2 | streptothricin-F + H2O = streptothricin-F acid | streptothricin-F hydrolase | None | sttH (gene name) | |
| 3.5.99.8 | 5-nitroanthranilic acid aminohydrolase | False | 1 | 14 | 4 | 1 | 5-nitroanthranilate + H2O = 5-nitrosalicylate + NH3 | 5-nitroanthranilate amidohydrolase | None | naaA (gene name); 5NAA deaminase | |
| 4.1.2.46 | aliphatic (R)-hydroxynitrile lyase | False | 1 | 0 | 3 | 2 | (2R)-2-hydroxy-2-methylbutanenitrile = cyanide + butan-2-one | (2R)-2-hydroxy-2-methylbutanenitrile butan-2-one-lyase (cyanide-forming) | None | (R)-HNL; (R)-oxynitrilase; (R)-hydroxynitrile lyase; LuHNL | |
| 4.1.2.47 | (S)-hydroxynitrile lyase | False | 2 | 0 | 5 | 4 | (1) an aliphatic (S)-hydroxynitrile = cyanide + an aliphatic aldehyde or ketone;;(2) an aromatic (S)-hydroxynitrile = cyanide + an aromatic aldehyde | (S)-cyanohydrin lyase (cyanide-forming) | None | (S)-cyanohydrin producing hydroxynitrile lyase; (S)-oxynitrilase; (S)-HbHNL; (S)-MeHNL; hydroxynitrile lyase; oxynitrilase; HbHNL; MeHNL; (S)-selective hydroxynitrile lyase; (S)-cyanohydrin carbonyl-lyase (cyanide forming) | |
| 4.1.3.41 | 3-hydroxy-D-aspartate aldolase | False | 2 | 133 | 0 | 1 | (1) threo-3-hydroxy-D-aspartate = glycine + glyoxylate;;(2) D-erythro-3-hydroxyaspartate = glycine + glyoxylate | 3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming) | None | D-3-hydroxyaspartate aldolase | |
| 4.2.1.121 | colneleate synthase | False | 4 | 1 | 0 | 3 | (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate = (8E)-9-[(1E,3Z)-nona-1,3-dien-1-yloxy]non-8-enoate + H2O | (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate hydro-lyase | None | 9-divinyl ether synthase; 9-DES; CYP74D; CYP74D1; CYP74 cytochrome P-450; DES1; (8E)-9-[(1E,3E)-nona-1,3-dien-1-yloxy]non-8-enoate synthase | |
| 4.3.1.27 | threo-3-hydroxy-D-aspartate ammonia-lyase | False | 1 | 162 | 8 | 1 | threo-3-hydroxy-D-aspartate = oxaloacetate + NH3 | threo-3-hydroxy-D-aspartate ammonia-lyase (oxaloacetate-forming) | None | D-threo-3-hydroxyaspartate dehydratase | |
| 6.3.2.36 | 4-phosphopantoate---beta-alanine ligase | False | 5 | 1996 | 3 | 2 | ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate | (R)-4-phosphopantoate:beta-alanine ligase (AMP-forming) | None | phosphopantothenate synthetase; TK1686 protein | |
| 1.1.1.310 | (S)-sulfolactate dehydrogenase | False | 2 | 236 | 0 | 1 | (2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+ | (2S)-sulfolactate:NAD+ oxidoreductase | None | (2S)-3-sulfolactate dehydrogenase; SlcC | |
| 1.1.1.311 | (S)-1-phenylethanol dehydrogenase | False | 1 | 211 | 2 | 2 | (S)-1-phenylethanol + NAD+ = acetophenone + NADH + H+ | (S)-1-phenylethanol:NAD+ oxidoreductase | None | PED | |
| 1.1.98.2 | glucose-6-phosphate dehydrogenase (coenzyme-F420) | False | 23 | 2340 | 1 | 14 | D-glucose 6-phosphate + oxidized coenzyme F420 = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420 | D-glucose-6-phosphate:F420 1-oxidoreductase | None | coenzyme F420-dependent glucose-6-phosphate dehydrogenase; F420-dependent glucose-6-phosphate dehydrogenase; FGD1; Rv0407; F420-dependent glucose-6-phosphate dehydrogenase 1 | |
| 1.3.7.7 | ferredoxin:protochlorophyllide reductase (ATP-dependent) | False | 327 | 8890 | 2 | 31 | chlorophyllide a + oxidized ferredoxin + 2 ADP + 2 phosphate = protochlorophyllide a + reduced ferredoxin + 2 ATP + 2 H2O | ATP-dependent ferredoxin:protochlorophyllide-a 7,8-oxidoreductase | None | light-independent protochlorophyllide reductase | |
| 1.5.3.18 | L-saccharopine oxidase | False | 1 | 0 | 0 | 2 | N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2 | L-saccharopine:oxygen oxidoreductase (L-glutamate-forming) | None | FAP2 | |
| 1.11.1.20 | prostamide/prostaglandin F2alpha synthase | False | 11 | 569 | 0 | 3 | thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate | thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase | None | prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase | |
| 1.11.2.2 | myeloperoxidase | False | 2 | 2 | 24 | 8 | Cl- + H2O2 + H+ = HClO + H2O | chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) | None | MPO; verdoperoxidase | |
| 1.11.2.3 | plant seed peroxygenase | False | 13 | 45 | 0 | 10 | R1H + R2OOH = R1OH + R2OH | substrate:hydroperoxide oxidoreductase (RH-hydroxylating or epoxidising) | None | plant peroxygenase; soybean peroxygenase | |
| 1.11.2.4 | fatty-acid peroxygenase | False | 2 | 165 | 9 | 5 | fatty acid + H2O2 = 3- or 2-hydroxy fatty acid + H2O | fatty acid:hydroperoxide oxidoreductase (RH-hydroxylating) | None | fatty acid hydroxylase (ambiguous); P450 peroxygenase; CYP152A1; P450BS; P450SPalpha | |
| 2.1.1.200 | tRNA (cytidine32/uridine32-2'-O)-methyltransferase | False | 28 | 14490 | 9 | 3 | (1) S-adenosyl-L-methionine + cytidine32 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA;;(2) S-adenosyl-L-methionine + uridine32 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA | S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2'-O)-methyltransferase | None | YfhQ; tRNA:Cm32/Um32 methyltransferase; TrMet(Xm32); TrmJ | |
| 2.1.1.201 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase | False | 285 | 16429 | 2 | 6 | S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol | S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase | None | ubiE (gene name, ambiguous) | |
| 2.1.1.202 | multisite-specific tRNA:(cytosine-C5)-methyltransferase | False | 1 | 66 | 0 | 12 | (1) S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor;;(2) S-adenosyl-L-methionine + cytosine40 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine40 in tRNA precursor;;(3) S-adenosyl-L-methionine + cytosine48 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine48 in tRNA;;(4) S-adenosyl-L-methionine + cytosine49 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine49 in tRNA | S-adenosyl-L-methionine:tRNA (cytosine-C5)-methyltransferase | None | multisite-specific tRNA:m5C-methyltransferase; TRM4 (gene name, gene corresponding to ORF YBL024w) | |
| 2.1.1.203 | tRNA (cytosine34-C5)-methyltransferase | False | 7 | 1911 | 0 | 7 | S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor | S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase | None | hTrm4 Mtase; hTrm4 methyltransferase; hTrm4 (gene name); tRNA:m5C-methyltransferase (ambiguous) | |
| 2.1.1.204 | tRNA (cytosine38-C5)-methyltransferase | False | 7 | 1781 | 1 | 9 | S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA | S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase | None | hDNMT2 (gene name); DNMT2 (gene name); TRDMT1 (gene name) | |
| 2.1.1.205 | tRNA (cytidine32/guanosine34-2'-O)-methyltransferase | False | 8 | 3073 | 2 | 1 | S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA | S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase | None | Trm7p | |
| 2.1.1.206 | tRNA (cytidine56-2'-O)-methyltransferase | False | 45 | 2664 | 0 | 3 | S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA | S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase | None | aTrm56; tRNA ribose 2'-O-methyltransferase aTrm56; PAB1040 (gene name) | |
| 2.3.1.193 | tRNAMet cytidine acetyltransferase | False | 21 | 4065 | 0 | 1 | [elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA + H2O = CoA + [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate | acetyl-CoA:[elongator tRNAMet]-cytidine34 N4-acetyltransferase (ATP-hydrolysing) | None | YpfI; TmcA | |
| 2.3.1.194 | acetoacetyl-CoA synthase | False | 1 | 31 | 0 | 4 | acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2 | acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating) | None | NphT7 | |
| 2.3.1.195 | (Z)-3-hexen-1-ol acetyltransferase | False | 1 | 0 | 0 | 1 | acetyl-CoA + (3Z)-hex-3-en-1-ol = CoA + (3Z)-hex-3-en-1-yl acetate | acetyl-CoA:(3Z)-hex-3-en-1-ol acetyltransferase | None | CHAT; At3g03480 | |
| 2.4.1.254 | cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-glucuronate + cyanidin 3-O-beta-D-glucoside = UDP + cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside | UDP-alpha-D-glucuronate:cyanidin-3-O-beta-D-glucoside 2-O-beta-D-glucuronosyltransferase | None | BpUGT94B1; UDP-glucuronic acid:anthocyanin glucuronosyltransferase; UDP-glucuronic acid:anthocyanidin 3-glucoside 2'-O-beta-glucuronosyltransferase; BpUGAT; UDP-D-glucuronate:cyanidin-3-O-beta-glucoside 2-O-beta-glucuronosyltransferase | |
| 2.4.1.255 | protein O-GlcNAc transferase | False | 24 | 16330 | 45 | 15 | (1) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine;; (2) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine | UDP-N-alpha-acetyl-D-glucosamine:[protein]-3-O-N-acetyl-beta-D-glucosaminyl transferase | None | O-GlcNAc transferase; OGTase; O-linked N-acetylglucosaminyltransferase; uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase; protein O-linked beta-N-acetylglucosamine transferase | |
| 2.7.7.73 | sulfur carrier protein ThiS adenylyltransferase | False | 3 | 732 | 0 | 2 | ATP + [ThiS] = diphosphate + adenylyl-[ThiS] | ATP:[ThiS] adenylyltransferase | None | thiF (gene name) | |
| 2.7.8.32 | 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase | False | 4 | 0 | 0 | 1 | UDP-xylose + 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose = UMP + 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose | UDP-D-xylose:3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase | None | XPT1 | |
| 3.2.1.169 | protein O-GlcNAcase | False | 7 | 246 | 42 | 10 | (1) [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O = [protein]-L-serine + N-acetyl-D-glucosamine ;; (2) [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-theronine + H2O = [protein]-L-threonine + N-acetyl-D-glucosamine | [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase | None | OGA; glycoside hydrolase O-GlcNAcase; O-GlcNAcase; BtGH84; O-GlcNAc hydrolase | |
| 4.2.3.55 | (S)-beta-bisabolene synthase | False | 7 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(S)-beta-bisabolene-forming] | None | None | |
| 4.2.3.56 | gamma-humulene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = gamma-humulene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (gamma-humulene-forming) | None | humulene cyclase | |
| 4.2.3.57 | (-)-beta-caryophyllene synthase | False | 18 | 13 | 0 | 13 | (2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-beta-caryophyllene-forming] | None | beta-caryophyllene synthase; (2E,6E)-farnesyl-diphosphate diphosphate-lyase (caryophyllene-forming) | |
| 4.2.3.58 | longifolene synthase | False | 2 | 2 | 0 | 1 | (2E,6E)-farnesyl diphosphate = longifolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (longifolene-forming) | None | None | |
| 4.2.3.59 | (E)-gamma-bisabolene synthase | False | 4 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-gamma-bisabolene-forming] | None | None | |
| 4.2.3.60 | germacrene C synthase | False | 2 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = germacrene C + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (germacrene-C-forming) | None | None | |
| 5.4.99.19 | 16S rRNA pseudouridine516 synthase | False | 13 | 565 | 0 | 1 | 16S rRNA uridine516 = 16S rRNA pseudouridine516 | 16S rRNA-uridine516 uracil mutase | None | 16S RNA pseudouridine516 synthase; 16S PsiI516 synthase; 16S RNA Psi516 synthase; RNA pseudouridine synthase RsuA; RsuA; 16S RNA pseudouridine 516 synthase | |
| 5.4.99.20 | 23S rRNA pseudouridine2457 synthase | False | 15 | 170 | 0 | 2 | 23S rRNA uridine2457 = 23S rRNA pseudouridine2457 | 23S rRNA-uridine2457 uracil mutase | None | RluE; YmfC | |
| 5.4.99.21 | 23S rRNA pseudouridine2604 synthase | False | 6 | 4599 | 0 | 1 | 23S rRNA uridine2604 = 23S rRNA pseudouridine2604 | 23S rRNA-uridine2604 uracil mutase | None | RluF; YjbC | |
| 5.4.99.22 | 23S rRNA pseudouridine2605 synthase | False | 21 | 561 | 3 | 1 | 23S rRNA uridine2605 = 23S rRNA pseudouridine2605 | 23S rRNA-uridine2605 uracil mutase | None | RluB; YciL | |
| 5.4.99.23 | 23S rRNA pseudouridine1911/1915/1917 synthase | False | 28 | 1570 | 1 | 2 | 23S rRNA uridine1911/uridine1915/uridine1917 = 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 | 23S rRNA-uridine1911/1915/1917 uracil mutase | None | RluD; pseudouridine synthase RluD | |
| 5.4.99.24 | 23S rRNA pseudouridine955/2504/2580 synthase | False | 22 | 3626 | 0 | 1 | 23S rRNA uridine955/uridine2504/uridine2580 = 23S rRNA pseudouridine955/pseudouridine2504/pseudouridine2580 | 23S rRNA-uridine955/2504/2580 uracil mutase | None | RluC; pseudouridine synthase RluC | |
| 5.4.99.25 | tRNA pseudouridine55 synthase | False | 532 | 47597 | 0 | 11 | tRNA uridine55 = tRNA pseudouridine55 | tRNA-uridine55 uracil mutase | None | TruB; aCbf5; Pus4; YNL292w (gene name); Psi55 tRNA pseudouridine synthase; tRNA:Psi55-synthase; tRNA pseudouridine 55 synthase; tRNA:pseudouridine-55 synthase; Psi55 synthase; tRNA Psi55 synthase; tRNA:Psi55 synthase; tRNA-uridine55 uracil mutase; Pus10; tRNA-uridine54/55 uracil mutase | |
| 5.4.99.26 | tRNA pseudouridine65 synthase | False | 14 | 5107 | 0 | 1 | tRNA uridine65 = tRNA pseudouridine65 | tRNA-uridine65 uracil mutase | None | TruC; YqcB | |
| 5.4.99.27 | tRNA pseudouridine13 synthase | False | 194 | 9919 | 0 | 5 | tRNA uridine13 = tRNA pseudouridine13 | tRNA-uridine13 uracil mutase | None | TruD; YgbO; tRNA PSI13 synthase; RNA:PSI-synthase Pus7p; Pus7p; RNA:pseudouridine-synthase Pus7p; Pus7 protein | |
| 5.4.99.28 | tRNA pseudouridine32 synthase | False | 15 | 5199 | 0 | 2 | tRNA uridine32 = tRNA pseudouridine32 | tRNA-uridine32 uracil mutase | None | RluA (ambiguous); pseudouridine synthase RluA (ambiguous); Pus9p; Rib2/Pus8p | |
| 5.4.99.29 | 23S rRNA pseudouridine746 synthase | False | 13 | 4622 | 0 | 1 | 23S rRNA uridine746 = 23S rRNA pseudouridine746 | 23S rRNA-uridine746 uracil mutase | None | RluA (ambiguous); 23S RNA PSI746 synthase; 23S rRNA pseudouridine synthase; pseudouridine synthase RluA (ambiguous) | |
| 5.4.99.30 | UDP-arabinopyranose mutase | False | 12 | 1439 | 1 | 5 | UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose | UDP-arabinopyranose pyranomutase | None | Os03g40270 protein; UAM1; UAM3; RGP1; RGP3; OsUAM1; OsUAM2; Os03g0599800 protein; Os07g41360 protein | |
| 5.5.1.17 | (S)-beta-macrocarpene synthase | False | 2 | 0 | 0 | 1 | (S)-beta-bisabolene = (S)-beta-macrocarpene | (S)-beta-macrocarpene lyase (ring-opening) | None | TPS6; TPS11; (S)-beta-macrocarpene lyase (decyclizing) | |
| 1.7.2.4 | nitrous-oxide reductase | False | 12 | 4952 | 24 | 32 | nitrogen + H2O + 2 ferricytochrome c = nitrous oxide + 2 ferrocytochrome c + 2 H+ | nitrogen:cytochrome c oxidoreductase (N2O-forming) | None | nitrous oxide reductase; N2O reductase; nitrogen:(acceptor) oxidoreductase (N2O-forming) | |
| 1.8.5.3 | respiratory dimethylsulfoxide reductase | False | 5 | 2942 | 0 | 6 | dimethylsulfide + menaquinone + H2O = dimethylsulfoxide + menaquinol | dimethyl sulfide:menaquinone oxidoreductase | None | dmsABC (gene names); DMSO reductase (ambiguous); dimethylsulfoxide reductase (ambiguous) | |
| 1.14.13.122 | chlorophyllide-a oxygenase | False | 4 | 25 | 0 | 12 | chlorophyllide a + 2 O2 + 2 NADPH + 2 H+ = chlorophyllide b + 3 H2O + 2 NADP+ (overall reaction);;(1a) chlorophyllide a + O2 + NADPH + H+ = 71-hydroxychlorophyllide a + H2O + NADP+;;(1b) 71-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+ | chlorophyllide-a:oxygen 71-oxidoreductase | None | chlorophyllide a oxygenase; chlorophyll-b synthase; CAO | |
| 2.4.1.256 | dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase | False | 20 | 3803 | 0 | 3 | dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol | dolichyl beta-D-glucosyl-phosphate:alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase (configuration-retaining) | None | ALG10; Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase; dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-glucosyltransferase | |
| 2.4.1.257 | GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase | False | 13 | 4478 | 0 | 2 | GDP-alpha-D-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = GDP + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol | GDP-alpha-D-mannose:alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 6-alpha-D-mannosyltransferase (configuration-retaining) | None | GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase; Alg2 mannosyltransferase (ambiguous); ALG2 (gene name, ambiguous); GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase (ambiguous); GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase | |
| 2.4.1.258 | dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase | False | 22 | 2562 | 0 | 9 | dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-mannosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-mannosyltransferase (configuration-inverting) | None | Man5GlcNAc2-PP-Dol mannosyltransferase; ALG3; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Not56-like protein; Alg3 alpha-1,3-mannosyl transferase; Dol-P-Man:Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase; dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-mannosyltransferase | |
| 2.4.1.259 | dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase | False | 6 | 2 | 0 | 3 | dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-mannosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase (configuration-inverting) | None | ALG9; ALG9 alpha1,2 mannosyltransferase; dolichylphosphomannose-dependent ALG9 mannosyltransferase; ALG9 mannosyltransferase; Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase; dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase | |
| 2.4.1.260 | dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase | False | 7 | 5 | 0 | 4 | dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-mannosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 6-alpha-D-mannosyltransferase (configuration-inverting) | None | ALG12; ALG12 mannosyltransferase; ALG12 alpha1,6mannosyltransferase; dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase; dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase; EBS4; Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase; dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase | |
| 2.4.1.261 | dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase | False | 6 | 1 | 0 | 3 | dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-mannosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase (configuration-inverting) | None | ALG9; ALG9 alpha1,2 mannosyltransferase; dolichylphosphomannose-dependent ALG9 mannosyltransferase; ALG9 mannosyltransferase; Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase; dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase | |
| 3.1.2.29 | fluoroacetyl-CoA thioesterase | False | 1 | 239 | 0 | 2 | fluoroacetyl-CoA + H2O = fluoroacetate + CoA | fluoroacetyl-CoA hydrolase | None | None | |
| 4.1.99.16 | geosmin synthase | False | 1 | 9 | 0 | 6 | (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone | germacradienol geosmin-lyase (acetone-forming) | None | None | |
| 4.2.3.61 | 5-epiaristolochene synthase | False | 6 | 97 | 19 | 3 | (2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-5-epiaristolochene-forming] | None | 5-epi-aristolochene synthase; tobacco epiaristolochene synthase; farnesyl pyrophosphate cyclase (ambiguous); EAS; TEAS | |
| 4.2.3.62 | (-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing] | False | 1 | 0 | 0 | 2 | (2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate | (2Z,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-gamma-cadinene-forming] | None | (-)-gamma-cadinene cyclase | |
| 4.2.3.63 | (+)-cubenene synthase | True | 0 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-cubenene-forming] | None | None | |
| 4.2.3.64 | (+)-epicubenol synthase | True | 0 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epicubenol-forming] | None | farnesyl pyrophosphate cyclase (ambiguous) | |
| 4.2.3.65 | zingiberene synthase | False | 3 | 4 | 0 | 3 | (2E,6E)-farnesyl diphosphate = zingiberene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (zingiberene-forming) | None | alpha-zingiberene synthase; ZIS | |
| 4.2.3.66 | beta-selinene cyclase | False | 1 | 2 | 0 | 2 | (2E,6E)-farnesyl diphosphate = beta-selinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (beta-selinene-forming) | None | None | |
| 4.2.3.67 | cis-muuroladiene synthase | False | 1 | 2 | 0 | 1 | (1) (2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate;; (2) (2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cis-muuroladiene-forming) | None | MxpSS1 | |
| 4.2.3.68 | beta-eudesmol synthase | False | 1 | 0 | 0 | 5 | (2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (beta-eudesmol-forming) | None | None | |
| 4.2.3.69 | (+)-alpha-barbatene synthase | False | 1 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-alpha-barbatene-forming] | None | AtBS | |
| 4.2.3.70 | patchoulol synthase | False | 1 | 2 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = patchoulol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming) | None | None | |
| 4.2.3.71 | (E,E)-germacrene B synthase | False | 3 | 1 | 0 | 3 | (2E,6E)-farnesyl diphosphate = (E,E)-germacrene B + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E,E)-germacrene-B-forming] | None | None | |
| 4.2.3.72 | alpha-gurjunene synthase | False | 1 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-alpha-gurjunene-forming] | None | None | |
| 4.2.3.73 | valencene synthase | False | 5 | 8 | 0 | 4 | (2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming) | None | None | |
| 6.4.1.8 | acetophenone carboxylase | False | 5 | 1394 | 1 | 1 | 2 ATP + acetophenone + HCO3- + H2O + H+ = 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate | acetophenone:carbon-dioxide ligase (ADP-forming) | None | None | |
| 1.1.1.312 | 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase | False | 1 | 490 | 0 | 3 | 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+ | 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase | None | 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase; 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase; alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase; 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; LigC; ProD | |
| 1.1.1.313 | sulfoacetaldehyde reductase (NADPH) | False | 3 | 294 | 1 | 4 | isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+ | isethionate:NADP+ oxidoreductase | None | isfD (gene name) | |
| 1.2.7.10 | oxalate oxidoreductase | False | 3 | 52 | 3 | 1 | oxalate + oxidized ferredoxin = 2 CO2 + reduced ferredoxin | oxalate:ferredoxin oxidoreductase | None | None | |
| 1.3.1.87 | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase | False | 20 | 921 | 0 | 1 | (1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+;;(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase | None | hcaB (gene name); cis-dihydrodiol dehydrogenase; 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase | |
| 1.3.5.5 | 15-cis-phytoene desaturase | False | 10 | 1609 | 0 | 19 | 15-cis-phytoene + 2 plastoquinone = 9,15,9'-tricis-zeta-carotene + 2 plastoquinol (overall reaction);; (1a) 15-cis-phytoene + plastoquinone = 15,9'-dicis-phytofluene + plastoquinol;; (1b) 15,9'-dicis-phytofluene + plastoquinone = 9,15,9'-tricis-zeta-carotene + plastoquinol | 15-cis-phytoene:plastoquinone oxidoreductase | None | phytoene desaturase (ambiguous); PDS; plant-type phytoene desaturase | |
| 1.3.7.8 | benzoyl-CoA reductase | False | 4 | 1529 | 0 | 15 | cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O | cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) | None | benzoyl-CoA reductase (dearomatizing) | |
| 1.3.8.1 | short-chain acyl-CoA dehydrogenase | False | 17 | 9216 | 24 | 21 | a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein | short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | None | butyryl-CoA dehydrogenase; butanoyl-CoA dehydrogenase; butyryl dehydrogenase; unsaturated acyl-CoA reductase; ethylene reductase; enoyl-coenzyme A reductase; unsaturated acyl coenzyme A reductase; butyryl coenzyme A dehydrogenase; short-chain acyl CoA dehydrogenase; short-chain acyl-coenzyme A dehydrogenase; 3-hydroxyacyl CoA reductase; butanoyl-CoA:(acceptor) 2,3-oxidoreductase; ACADS (gene name). | |
| 1.3.98.1 | dihydroorotate dehydrogenase (fumarate) | False | 40 | 1541 | 60 | 20 | (S)-dihydroorotate + fumarate = orotate + succinate | (S)-dihydroorotate:fumarate oxidoreductase | None | DHOdehase (ambiguous); dihydroorotate dehydrogenase (ambiguous); dihydoorotic acid dehydrogenase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase; pyr4 (gene name) | |
| 1.6.5.9 | NADH:quinone reductase (non-electrogenic) | False | 35 | 24096 | 10 | 10 | NADH + H+ + a quinone = NAD+ + a quinol | NADH:quinone oxidoreductase | None | type II NAD(P)H:quinone oxidoreductase; NDE2 (gene name); ndh (gene name); NDH-II; NDH-2; NADH dehydrogenase (quinone) (ambiguous); ubiquinone reductase (ambiguous); coenzyme Q reductase (ambiguous); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (ambiguous); DPNH-ubiquinone reductase (ambiguous); NADH-coenzyme Q oxidoreductase (ambiguous); NADH-coenzyme Q reductase (ambiguous); NADH-CoQ oxidoreductase (ambiguous); NADH-CoQ reductase (ambiguous); NADH-ubiquinone reductase (ambiguous); NADH-ubiquinone oxidoreductase (ambiguous); reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); NADH-Q6 oxidoreductase (ambiguous); NADH2 dehydrogenase (ubiquinone) (ambiguous); NADH:ubiquinone oxidoreductase; NADH:ubiquinone reductase (non-electrogenic) | |
| 1.7.1.14 | nitric oxide reductase [NAD(P)+, nitrous oxide-forming] | False | 1 | 10 | 9 | 6 | N2O + NAD(P)+ + H2O = 2 NO + NAD(P)H + H+ | nitrous oxide:NAD(P) oxidoreductase | None | fungal nitric oxide reductase; cytochrome P450nor; NOR (ambiguous) | |
| 1.7.2.5 | nitric oxide reductase (cytochrome c) | False | 2 | 967 | 14 | 51 | nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ferrocytochrome c + 2 H+ | nitrous oxide:ferricytochrome-c oxidoreductase | None | None | |
| 1.7.5.2 | nitric oxide reductase (menaquinol) | False | 0 | 19 | 0 | 2 | 2 nitric oxide + menaquinol = nitrous oxide + menaquinone + H2O | None | None | None | |
| 1.8.1.17 | dimethylsulfone reductase | True | 0 | 0 | 0 | 2 | dimethyl sulfoxide + H2O + NAD+ = dimethyl sulfone + NADH + H+ | None | None | None | |
| 1.8.2.3 | sulfide-cytochrome-c reductase (flavocytochrome c) | False | 2 | 457 | 0 | 6 | hydrogen sulfide + 2 ferricytochrome c = sulfur + 2 ferrocytochrome c + 2 H+ | hydrogen-sulfide:flavocytochrome c oxidoreductase | None | None | |
| 1.8.2.4 | dimethyl sulfide:cytochrome c2 reductase | False | 1 | 78 | 0 | 1 | dimethyl sulfide + 2 ferricytochrome c2 + H2O = dimethyl sulfoxide + 2 ferrocytochrome c2 + 2 H+ | dimethyl sulfide:cytochrome-c2 oxidoreductase | None | Ddh (gene name) | |
| 1.8.3.6 | farnesylcysteine lyase | False | 1 | 10 | 0 | 1 | S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2 | S-(2E,6E)-farnesyl-L-cysteine oxidase | None | FC lyase; FCLY | |
| 1.8.5.4 | bacterial sulfide:quinone reductase | False | 3 | 140 | 2 | 22 | n HS- + n quinone = polysulfide + n quinol | sulfide:quinone oxidoreductase (polysulfide-producing) | None | sqr (gene name); sulfide:quinone reductase (ambiguous); sulfide:quinone oxidoreductase | |
| 1.10.3.9 | photosystem II | False | 389 | 28822 | 128 | 15 | 2 H2O + 2 plastoquinone + 4 hnu = O2 + 2 plastoquinol | H2O:plastoquinone reductase (light-dependent) | None | None | |
| 1.10.3.11 | ubiquinol oxidase (non-electrogenic) | False | 18 | 2285 | 0 | 22 | 2 ubiquinol + O2 = 2 ubiquinone + 2 H2O | ubiquinol:oxygen oxidoreductase (non-electrogenic) | None | plant alternative oxidase; cyanide-insensitive oxidase; AOX (gene name); ubiquinol oxidase; ubiquinol:O2 oxidoreductase (non-electrogenic) | |
| 1.11.1.21 | catalase-peroxidase | False | 342 | 19252 | 84 | 28 | (1) donor + H2O2 = oxidized donor + 2 H2O;; (2) 2 H2O2 = O2 + 2 H2O | donor:hydrogen-peroxide oxidoreductase | None | katG (gene name) | |
| 1.12.1.4 | hydrogenase (NAD+, ferredoxin) | False | 3 | 7 | 4 | 4 | 2 H2 + NAD+ + 2 oxidized ferredoxin = 5 H+ + NADH + 2 reduced ferredoxin | hydrogen:NAD+, ferredoxin oxidoreductase | None | bifurcating [FeFe] hydrogenase | |
| 1.13.11.57 | gallate dioxygenase | False | 1 | 350 | 0 | 3 | 3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate | 3,4,5-trihydroxybenzoate:oxygen oxidoreductase | None | GalA; gallate:oxygen oxidoreductase | |
| 1.13.11.58 | linoleate 9S-lipoxygenase | False | 31 | 29 | 7 | 18 | linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate | linoleate:oxygen 9S-oxidoreductase | None | 9-lipoxygenase; 9S-lipoxygenase; linoleate 9-lipoxygenase; LOX1 (gene name); 9S-LOX | |
| 1.14.11.33 | DNA oxidative demethylase | False | 14 | 1767 | 14 | 11 | DNA-base-CH3 + 2-oxoglutarate + O2 = DNA-base + formaldehyde + succinate + CO2 | methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | None | alkylated DNA repair protein; alpha-ketoglutarate-dependent dioxygenase ABH1; alkB (gene name) | |
| 1.14.13.127 | 3-(3-hydroxyphenyl)propanoate hydroxylase | False | 31 | 1983 | 0 | 2 | (1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+;; (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ | 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating) | None | mhpA (gene name) | |
| 1.14.13.128 | 7-methylxanthine demethylase | False | 1 | 35 | 0 | 1 | 7-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde | 7-methylxanthine:oxygen oxidoreductase (demethylating) | None | ndmC (gene name) | |
| 1.14.13.130 | pyrrole-2-carboxylate monooxygenase | False | 1 | 1 | 0 | 2 | pyrrole-2-carboxylate + NADH + H+ + O2 = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O | pyrrole-2-carboxylate,NADH:oxygen oxidoreductase (5-hydroxylating) | None | pyrrole-2-carboxylate oxygenase | |
| 1.14.18.3 | methane monooxygenase (particulate) | False | 2 | 549 | 15 | 14 | methane + quinol + O2 = methanol + quinone + H2O | methane,quinol:oxygen oxidoreductase | None | None | |
| 1.14.99.44 | diapolycopene oxygenase | False | 1 | 123 | 0 | 2 | 4,4'-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4'-diapolycopenedial + 4 acceptor + 6 H2O | 4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating) | None | crtP (ambiguous) | |
| 2.1.1.207 | tRNA (cytidine34-2'-O)-methyltransferase | False | 26 | 25238 | 14 | 1 | (1) S-adenosyl-L-methionine + cytidine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine34 in tRNA;;(2) S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine34 in tRNALeu = S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNALeu | S-adenosyl-L-methionine:tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase | None | yibK (gene name); methyltransferase yibK; TrmL; tRNA methyltransferase L; tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase | |
| 2.3.1.196 | benzyl alcohol O-benzoyltransferase | False | 4 | 66 | 0 | 6 | benzoyl-CoA + benzyl alcohol = CoA + benzyl benzoate | benzoyl-CoA:benzyl alcohol O-benzoyltransferase | None | benzoyl-CoA:benzyl alcohol benzoyltransferase; benzoyl-CoA:benzyl alcohol/phenylethanol benzoyltransferase; benzoyl-coenzyme A:benzyl alcohol benzoyltransferase; benzoyl-coenzyme A:phenylethanol benzoyltransferase | |
| 2.4.1.262 | soyasapogenol glucuronosyltransferase | True | 0 | 0 | 0 | 2 | UDP-alpha-D-glucuronate + soyasapogenol B = UDP + soyasapogenol B 3-O-beta-D-glucuronide | UDP-alpha-D-glucuronate:soyasapogenol 3-O-D-glucuronosyltransferase (configuration-inverting) | None | UGASGT; UDP-D-glucuronate:soyasapogenol 3-O-D-glucuronosyltransferase | |
| 2.4.1.263 | abscisate beta-glucosyltransferase | False | 3 | 5 | 0 | 2 | UDP-alpha-D-glucose + abscisate = UDP + beta-D-glucopyranosyl abscisate | UDP-alpha-D-glucose:abscisate beta-D-glucosyltransferase (configuration-inverting) | None | ABA-glucosyltransferase; ABA-GTase; AOG; UDP-D-glucose:abscisate beta-D-glucosyltransferase | |
| 2.7.1.170 | anhydro-N-acetylmuramic acid kinase | False | 261 | 17708 | 6 | 3 | ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate | ATP:1,6-anhydro-N-acetyl-beta-muramate 6-phosphotransferase | None | anhMurNAc kinase; AnmK | |
| 3.1.1.86 | rhamnogalacturonan acetylesterase | False | 2 | 8 | 0 | 2 | Hydrolytic cleavage of 2-O-acetyl- or 3-O-acetyl groups of alpha-D-galacturonic acid in rhamnogalacturonan I. | rhamnogalacturonan 2/3-O-acetyl-alpha-D-galacturonate O-acetylhydrolase | None | RGAE | |
| 3.1.3.84 | ADP-ribose 1''-phosphate phosphatase | False | 45 | 2640 | 117 | 3 | ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate | ADP-D-ribose 1''-phosphate phosphohydrolase | None | POA1; Appr1p phosphatase; Poa1p; ADP-ribose 1''-phosphate phosphohydrolase | |
| 3.2.1.170 | mannosylglycerate hydrolase | False | 2 | 1021 | 0 | 2 | 2-O-(alpha-D-mannopyranosyl)-D-glycerate + H2O = D-mannopyranose + D-glycerate | 2-O-(alpha-D-mannopyranosyl)-D-glycerate D-mannohydrolase | None | MgH | |
| 4.2.1.122 | tryptophan synthase (indole-salvaging) | False | 0 | 18 | 0 | 5 | L-serine + indole = L-tryptophan + H2O | L-serine hydro-lyase [adding indole, L-tryptophan-forming] | None | tryptophan synthase beta2 | |
| 4.2.1.123 | tetrahymanol synthase | False | 1 | 0 | 0 | 9 | tetrahymanol = squalene + H2O | squalene hydro-lyase (tetrahymanol-forming) | None | None | |
| 4.2.1.124 | arabidiol synthase | False | 1 | 0 | 0 | 1 | arabidiol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O | (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (arabidiol-forming) | None | PEN1 (gene name); (S)-squalene-2,3-epoxide hydro-lyase (arabidiol forming) | |
| 4.2.1.125 | dammarenediol II synthase | False | 1 | 0 | 0 | 3 | dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O | (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II-forming) | None | dammarenediol synthase; 2,3-oxidosqualene (20S)-dammarenediol cyclase; DDS; (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming) | |
| 4.2.1.126 | N-acetylmuramic acid 6-phosphate etherase | False | 204 | 14744 | 3 | 7 | (R)-lactate + N-acetyl-D-glucosamine 6-phosphate = N-acetylmuramate 6-phosphate + H2O | (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming) | None | MurNAc-6-P etherase; MurQ | |
| 4.2.3.74 | presilphiperfolanol synthase | False | 1 | 0 | 2 | 1 | (2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8beta-ol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8beta-ol-forming) | None | BcBOT2; CND15 | |
| 5.4.99.31 | thalianol synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = thalianol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, thalianol-forming) | None | (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming) | |
| 5.4.99.32 | protostadienol synthase | False | 4 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3beta-ol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming] | None | PdsA; (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming] | |
| 5.4.99.33 | cucurbitadienol synthase | False | 2 | 0 | 0 | 3 | (3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, cucurbitadienol-forming) | None | CPQ (gene name); (S)-2,3-epoxysqualene mutase (cyclizing, cucurbitadienol-forming) | |
| 5.4.99.34 | germanicol synthase | False | 2 | 0 | 0 | 2 | (3S)-2,3-epoxy-2,3-dihydrosqualene = germanicol | (3S)-2,3-epoxy-2,3-dihydrosqualenee mutase (cyclizing, germanicol-forming) | None | RsM1; (S)-2,3-epoxysqualene mutase (cyclizing, germanicol-forming) | |
| 5.4.99.35 | taraxerol synthase | False | 2 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, taraxerol-forming) | None | RsM2; (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming) | |
| 5.4.99.36 | isomultiflorenol synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = isomultiflorenol | (3S)-2,3-epoxy-2,3-dihydrosqualenee mutase (cyclizing, isomultiflorenol-forming) | None | LcIMS1; (S)-2,3-epoxysqualene mutase (cyclizing, isomultiflorenol-forming) | |
| 6.3.2.37 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---D-lysine ligase | False | 1 | 50 | 1 | 1 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + D-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-Nepsilon-D-lysine | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:D-lysine gamma-ligase (ADP-forming) | None | UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase; D-lysine-adding enzyme | |
| 4.2.3.75 | (-)-germacrene D synthase | False | 9 | 27 | 0 | 7 | (2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-germacrene-D-forming] | None | None | |
| 4.2.3.76 | (+)-delta-selinene synthase | False | 2 | 1 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-delta-selinene-forming] | None | None | |
| 4.2.3.77 | (+)-germacrene D synthase | False | 4 | 2 | 0 | 4 | (2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming] | None | None | |
| 1.3.5.6 | 9,9'-dicis-zeta-carotene desaturase | False | 10 | 1356 | 0 | 12 | 9,9'-dicis-zeta-carotene + 2 quinone = 7,9,7',9'-tetracis-lycopene + 2 quinol (overall reaction);;(1a) 9,9'-dicis-zeta-carotene + a quinone = 7,9,9'-tricis-neurosporene + a quinol;;(1b) 7,9,9'-tricis-neurosporene + a quinone = 7,9,7',9'-tetracis-lycopene + a quinol | 9,9'-dicis-zeta-corotene:quinone oxidoreductase | None | zeta-carotene desaturase; ZDS | |
| 1.3.99.26 | all-trans-zeta-carotene desaturase | False | 1 | 351 | 0 | 1 | all-trans-zeta-carotene + 2 acceptor = all-trans-lycopene + 2 reduced acceptor (overall reaction);;(1a) all-trans-zeta-carotene + acceptor = all-trans-neurosporene + reduced acceptor;;(1b) all-trans-neurosporene + acceptor = all-trans-lycopene + reduced acceptor | all-trans-zeta-carotene:acceptor oxidoreductase | None | CrtIb; phytoene desaturase (ambiguous); 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous); CrtI (ambiguous) | |
| 1.3.99.27 | 1-hydroxycarotenoid 3,4-desaturase | False | 5 | 105 | 0 | 9 | 1-hydroxy-1,2-dihydrolycopene + acceptor = 1-hydroxy-3,4-didehydro-1,2-dihydrolycopene + reduced acceptor | 1-hydroxy-1,2-dihydrolycopene:acceptor oxidoreductase | None | CrtD; hydroxyneurosporene desaturase; carotenoid 3,4-dehydrogenase; 1-hydroxy-carotenoid 3,4-dehydrogenase | |
| 1.3.99.28 | phytoene desaturase (neurosporene-forming) | False | 2 | 317 | 0 | 8 | 15-cis-phytoene + 3 acceptor = all-trans-neurosporene + 3 reduced acceptor (overall reaction);;(1a) 15-cis-phytoene + acceptor = all-trans-phytofluene + reduced acceptor;;(1b) all-trans-phytofluene + acceptor = all-trans-zeta-carotene + reduced acceptor;;(1c) all-trans-zeta-carotene + acceptor = all-trans-neurosporene + reduced acceptor | 15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming) | None | 3-step phytoene desaturase; three-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous) | |
| 1.3.99.29 | phytoene desaturase (zeta-carotene-forming) | False | 1 | 374 | 0 | 6 | 15-cis-phytoene + 2 acceptor = all-trans-zeta-carotene + 2 reduced acceptor (overall reaction);;(1a) 15-cis-phytoene + acceptor = all-trans-phytofluene + reduced acceptor;;(1b) all-trans-phytofluene + acceptor = all-trans-zeta-carotene + reduced acceptor | 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) | None | CrtIa; 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous) | |
| 1.3.99.30 | phytoene desaturase (3,4-didehydrolycopene-forming) | False | 2 | 12 | 0 | 4 | 15-cis-phytoene + 5 acceptor = all-trans-3,4-didehydrolycopene + 5 reduced acceptor (overall reaction);;(1a) 15-cis-phytoene + acceptor = all-trans-phytofluene + reduced acceptor;;(1b) all-trans-phytofluene + acceptor = all-trans-zeta-carotene + reduced acceptor;;(1c) all-trans-zeta-carotene + acceptor = all-trans-neurosporene + reduced acceptor;;(1d) all-trans-neurosporene + acceptor = all-trans-lycopene + reduced acceptor;;(1e) all-trans-lycopene + acceptor = all-trans-3,4-didehydrolycopene + reduced acceptor | 15-cis-phytoene:acceptor oxidoreductase (3,4-didehydrolycopene-forming) | None | 5-step phytoene desaturase; five-step phytoene desaturase; phytoene desaturase (ambiguous); Al-1 | |
| 1.3.99.31 | phytoene desaturase (lycopene-forming) | False | 3 | 401 | 0 | 13 | 15-cis-phytoene + 4 acceptor = all-trans-lycopene + 4 reduced acceptor (overall reaction);;(1a) 15-cis-phytoene + acceptor = all-trans-phytofluene + reduced acceptor;;(1b) all-trans-phytofluene + acceptor = all-trans-zeta-carotene + reduced acceptor;;(1c) all-trans-zeta-carotene + acceptor = all-trans-neurosporene + reduced acceptor;;(1d) all-trans-neurosporene + acceptor = all-trans-lycopene + reduced acceptor | 15-cis-phytoene:acceptor oxidoreductase (lycopene-forming) | None | 4-step phytoene desaturase; four-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous) | |
| 1.5.1.36 | flavin reductase (NADH) | False | 16 | 1701 | 3 | 12 | reduced flavin + NAD+ = flavin + NADH + H+ | flavin:NAD+ oxidoreductase | None | NADH-dependent flavin reductase; flavin:NADH oxidoreductase | |
| 1.16.1.9 | ferric-chelate reductase (NADPH) | False | 13 | 7360 | 0 | 7 | 2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH | Fe(II)-siderophore:NADP+ oxidoreductase | None | ferric chelate reductase (ambiguous); iron chelate reductase (ambiguous); NADPH:Fe3+-EDTA reductase; NADPH-dependent ferric reductase; yqjH (gene name); Fe(II):NADP+ oxidoreductase | |
| 1.97.1.12 | photosystem I | False | 457 | 44547 | 101 | 16 | reduced plastocyanin + oxidized ferredoxin + hnu = oxidized plastocyanin + reduced ferredoxin | plastocyanin:ferredoxin oxidoreductase (light-dependent) | None | None | |
| 2.1.1.209 | 23S rRNA (guanine2535-N1)-methyltransferase | False | 1 | 9 | 0 | 1 | S-adenosyl-L-methionine + guanine2535 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase | None | AviRa | |
| 2.1.1.210 | demethylspheroidene O-methyltransferase | False | 3 | 185 | 0 | 8 | S-adenosyl-L-methionine + demethylspheroidene = S-adenosyl-L-homocysteine + spheroidene | S-adenosyl-L-methionine:demethylspheroidene O-methyltransferase | None | 1-hydroxycarotenoid O-methylase; 1-hydroxycarotenoid methylase; 1-HO-carotenoid methylase; CrtF | |
| 2.4.1.264 | D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase | False | 2 | 38 | 0 | 2 | UDP-alpha-D-glucuronate + alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-glucuronate:alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-ditrans,octacis-undecaprenol beta-1,2-glucuronosyltransferase (configuration-inverting) | None | GumK; UDP-glucuronate:D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol beta-1,2-glucuronyltransferase; D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase | |
| 2.4.1.265 | dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase | False | 20 | 94 | 0 | 4 | dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-glucosyl-phosphate:alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-glucosyltransferase (configuration-inverting) | None | ALG8; Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase; dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase | |
| 2.4.1.266 | glucosyl-3-phosphoglycerate synthase | False | 8 | 4513 | 21 | 10 | NDP-glucose + 3-phospho-D-glycerate = NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate | NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase | None | GpgS protein; GPG synthase; glucosylphosphoglycerate synthase | |
| 2.4.1.267 | dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase | False | 11 | 169 | 2 | 4 | dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate | dolichyl beta-D-glucosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-glucosyltransferase (configuration-inverting) | None | ALG6; Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase; dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase | |
| 2.4.1.268 | glucosylglycerate synthase | False | 1 | 13 | 0 | 2 | ADP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP | ADP-glucose:D-glycerate 2-alpha-D-glucosyltransferase | None | Ggs (gene name) | |
| 2.4.1.269 | mannosylglycerate synthase | False | 2 | 1 | 0 | 2 | GDP-alpha-D-mannose + D-glycerate = GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate | GDP-alpha-D-mannose:D-glycerate 2-alpha-D-mannosyltransferase | None | None | |
| 2.4.1.270 | mannosylglucosyl-3-phosphoglycerate synthase | False | 1 | 5 | 0 | 2 | GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-O-[2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl]-3-phospho-D-glycerate | GDP-mannose:2-O-(alpha-D-glucosyl)-3-phospho-D-glycerate 2-O-alpha-D-mannosyltransferase | None | MggA | |
| 2.4.2.44 | S-methyl-5'-thioinosine phosphorylase | False | 12 | 2417 | 0 | 1 | S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate | S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase | None | MTIP; MTI phosphorylase; methylthioinosine phosphorylase | |
| 2.7.1.171 | protein-fructosamine 3-kinase | False | 2 | 2 | 0 | 6 | ATP + [protein]-N6-D-fructosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine | ATP:[protein]-N6-D-fructosyl-L-lysine 3-phosphotransferase | None | FN3K; fructosamine 3-kinase | |
| 2.7.1.172 | protein-ribulosamine 3-kinase | False | 7 | 5555 | 1 | 9 | ATP + [protein]-N6-D-ribulosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine | ATP:[protein]-N6-D-ribulosyl-L-lysine 3-phosphotransferase | None | Fn3KRP; FN3K-related protein; FN3K-RP; ketosamine 3-kinase 2; fructosamine-3-kinase-related protein; ribulosamine/erythrulosamine 3-kinase; ribulosamine 3-kinase | |
| 2.7.7.74 | 1L-myo-inositol 1-phosphate cytidylyltransferase | False | 5 | 973 | 12 | 7 | CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol | CTP:1L-myo-inositol 1-phosphate cytidylyltransferase | None | CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); L-myo-inositol-1-phosphate cytidylyltransferase | |
| 2.7.7.75 | molybdopterin adenylyltransferase | False | 15 | 5464 | 19 | 3 | ATP + molybdopterin = diphosphate + adenylyl-molybdopterin | ATP:molybdopterin adenylyltransferase | None | MogA; Cnx1 (ambiguous) | |
| 2.7.7.76 | molybdenum cofactor cytidylyltransferase | False | 1 | 782 | 0 | 1 | CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor | CTP:molybdenum cofactor cytidylyltransferase | None | MocA; CTP:molybdopterin cytidylyltransferase; MoCo cytidylyltransferase; Mo-MPT cytidyltransferase | |
| 2.7.8.34 | CDP-L-myo-inositol myo-inositolphosphotransferase | False | 5 | 968 | 0 | 4 | CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase | None | CDP-inositol:inositol-1-phosphate transferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); DIPPS (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)) | |
| 2.10.1.1 | molybdopterin molybdotransferase | False | 26 | 51296 | 13 | 2 | adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP + H2O | adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming) | None | MoeA; Cnx1 (ambiguous) | |
| 3.1.1.87 | fumonisin B1 esterase | False | 1 | 12 | 0 | 2 | fumonisin B1 + 2 H2O = aminopentol + 2 propane-1,2,3-tricarboxylate | fumonisin B1 acylhydrolase | None | fumD (gene name) | |
| 3.1.1.88 | pyrethroid hydrolase | False | 6 | 205 | 0 | 9 | trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate | pyrethroid-ester hydrolase | None | pyrethroid-hydrolyzing carboxylesterase; pyrethroid-hydrolysing esterase; pyrethroid-hydrolyzing esterase; pyrethroid-selective esterase; pyrethroid-cleaving enzyme; permethrinase; PytH; EstP | |
| 3.1.3.85 | glucosyl-3-phosphoglycerate phosphatase | False | 5 | 69 | 2 | 6 | 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate | alpha-D-glucosyl-3-phospho-D-glycerate phosphohydrolase | None | GpgP protein | |
| 3.2.1.171 | rhamnogalacturonan hydrolase | False | 14 | 3 | 0 | 4 | Endohydrolysis of alpha-D-GalA-(1->2)-alpha-L-Rha glycosidic bond in the rhamnogalacturonan I backbone with initial inversion of anomeric configuration releasing oligosaccharides with beta-D-GalA at the reducing end. | rhamnogalacturonan alpha-D-GalA-(1->2)-alpha-L-Rha hydrolase | None | rhamnogalacturonase A; RGase A; RG-hydrolase | |
| 3.2.1.172 | unsaturated rhamnogalacturonyl hydrolase | False | 2 | 861 | 2 | 2 | 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose | 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose hydrolase | None | YteR; YesR | |
| 3.2.1.173 | rhamnogalacturonan galacturonohydrolase | True | 0 | 0 | 0 | 1 | Exohydrolysis of the alpha-D-GalA-(1->2)-alpha-L-Rha bond in rhamnogalacturonan oligosaccharides with initial inversion of configuration releasing D-galacturonic acid from the non-reducing end of rhamnogalacturonan oligosaccharides. | rhamnogalacturonan oligosaccharide alpha-D-GalA-(1->2)-alpha-L-Rha galacturonohydrolase | None | RG-galacturonohydrolase | |
| 3.2.1.174 | rhamnogalacturonan rhamnohydrolase | True | 0 | 0 | 0 | 2 | Exohydrolysis of the alpha-L-Rha-(1->4)-alpha-D-GalA bond in rhamnogalacturonan oligosaccharides with initial inversion of configuration releasing beta-L-rhamnose from the non-reducing end of rhamnogalacturonan oligosaccharides. | rhamnogalacturonan oligosaccharide alpha-L-Rha-(1->4)-alpha-D-GalA rhamnohydrolase | None | RG-rhamnohydrolase; RG alpha-L-rhamnopyranohydrolase | |
| 3.2.1.175 | beta-D-glucopyranosyl abscisate beta-glucosidase | False | 1 | 1 | 0 | 2 | D-glucopyranosyl abscisate + H2O = D-glucose + abscisate | beta-D-glucopyranosyl abscisate glucohydrolase | None | AtBG1; ABA-beta-D-glucosidase; ABA-specific beta-glucosidase; ABA-GE hydrolase; beta-D-glucopyranosyl abscisate hydrolase | |
| 3.4.11.25 | beta-peptidyl aminopeptidase | False | 2 | 143 | 0 | 3 | Cleaves N-terminal beta-homoamino acids from peptides composed of 2 to 6 amino acids | None | None | BapA (ambiguous) | |
| 3.5.4.31 | S-methyl-5'-thioadenosine deaminase | False | 82 | 7550 | 0 | 3 | S-methyl-5'-thioadenosine + H2O = S-methyl-5'-thioinosine + NH3 | S-methyl-5'-thioadenosine amidohydrolase | None | MTA deaminase; 5-methylthioadenosine deaminase | |
| 4.1.1.91 | salicylate decarboxylase | False | 1 | 0 | 3 | 1 | salicylate = phenol + CO2 | salicylate carboxy-lyase | None | salicylic acid decarboxylase; Scd | |
| 4.1.1.92 | indole-3-carboxylate decarboxylase | True | 0 | 0 | 0 | 1 | indole-3-carboxylate = indole + CO2 | indole-3-carboxylate carboxy-lyase | None | None | |
| 4.2.1.127 | linalool dehydratase | False | 1 | 13 | 7 | 2 | (3S)-linalool = myrcene + H2O | (3S)-linalool hydro-lyase (myrcene-forming) | None | linalool hydro-lyase (myrcene-forming) | |
| 4.2.1.128 | lupan-3beta,20-diol synthase | False | 1 | 0 | 0 | 1 | lupan-3beta,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O | (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (lupan-3beta,20-diol-forming) | None | LUP1 (gene name) | |
| 4.2.1.129 | squalene---hopanol cyclase | False | 5 | 483 | 0 | 7 | hopan-22-ol = squalene + H2O | hopan-22-ol hydro-lyase | None | squalene---hopene cyclase (ambiguous) | |
| 4.2.2.23 | rhamnogalacturonan endolyase | False | 24 | 5270 | 0 | 10 | Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end. | alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronate endolyase | None | rhamnogalacturonase B; alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase; Rgase B; rhamnogalacturonan alpha-L-rhamnopyranosyl-(1,4)-alpha-D-galactopyranosyluronide lyase; RG-lyase; YesW; RGL4; Rgl11A; Rgl11Y; RhiE | |
| 4.2.2.24 | rhamnogalacturonan exolyase | False | 1 | 7 | 0 | 2 | Exotype eliminative cleavage of alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I oligosaccharides containing alpha-L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end. The products are the disaccharide 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose and the shortened rhamnogalacturonan oligosaccharide containing one 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end. | alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronate exolyase | None | YesX | |
| 5.2.1.13 | prolycopene isomerase | False | 5 | 1133 | 0 | 5 | 7,9,7',9'-tetracis-lycopene = all-trans-lycopene | 7,9,7',9'-tetracis-lycopene cis-trans-isomerase | None | CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase | |
| 5.3.3.17 | trans-2,3-dihydro-3-hydroxyanthranilate isomerase | False | 3 | 670 | 1 | 1 | (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate | (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase | None | phzF (gene name); (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase (incorrect) | |
| 5.4.4.4 | geraniol isomerase | False | 1 | 0 | 0 | 1 | geraniol = (3S)-linalool | geraniol hydroxymutase | None | None | |
| 5.4.99.37 | dammaradiene synthase | False | 1 | 7 | 0 | 1 | squalene = dammara-20,24-diene | squalene mutase (cyclizing, dammara-20,24-diene-forming) | None | None | |
| 5.4.99.38 | camelliol C synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming) | None | CAMS1; LUP3 (gene name) | |
| 5.4.99.39 | beta-amyrin synthase | False | 14 | 23 | 0 | 31 | (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming) | None | 2,3-oxidosqualene beta-amyrin cyclase; AsbAS1; BPY; EtAS; GgbAS1; LjAMY1; MtAMY1; PNY; BgbAS | |
| 5.4.99.40 | alpha-amyrin synthase | False | 3 | 6 | 0 | 6 | (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming) | None | 2,3-oxidosqualene alpha-amyrin cyclase; mixed amyrin synthase | |
| 5.4.99.41 | lupeol synthase | False | 7 | 12 | 0 | 10 | (3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming) | None | LUPI; BPW; RcLUS | |
| 6.2.1.37 | 3-hydroxybenzoate---CoA ligase | False | 1 | 8 | 0 | 4 | ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA | 3-hydroxybenzoate:CoA ligase (AMP-forming) | None | 3-hydroxybenzoyl-CoA synthetase; 3-hydroxybenzoate---coenzyme A ligase (AMP-forming); 3-hydroxybenzoyl coenzyme A synthetase; 3-hydroxybenzoyl-CoA ligase | |
| 6.3.4.19 | tRNAIle-lysidine synthase | False | 323 | 44537 | 0 | 6 | [tRNAIle2]-cytidine34 + L-lysine + ATP = [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O | L-lysine:[tRNAIle2]-cytidine34 ligase (AMP-forming) | None | TilS; mesJ (gene name); yacA (gene name); isoleucine-specific transfer ribonucleate lysidine synthetase; tRNAIle-lysidine synthetase | |
| 1.3.1.89 | tRNA-dihydrouridine47 synthase [NAD(P)+] | False | 41 | 2368 | 0 | 1 | 5,6-dihydrouracil47 in tRNA + NAD(P)+ = uracil47 in tRNA + NAD(P)H + H+ | tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase | None | Dus3p; tRNA-dihydrouridine synthase 3 | |
| 1.3.1.90 | tRNA-dihydrouridine20a/20b synthase [NAD(P)+] | False | 4 | 28 | 0 | 1 | (1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+;;(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+ | tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase | None | Dus4p | |
| 1.3.1.91 | tRNA-dihydrouridine20 synthase [NAD(P)+] | False | 27 | 12207 | 0 | 3 | 5,6-dihydrouracil20 in tRNA + NAD(P)+ = uracil20 in tRNA + NAD(P)H + H+ | tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase | None | Dus2p; tRNA-dihydrouridine synthase 2 | |
| 1.3.8.2 | 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) | False | 1 | 295 | 0 | 8 | 15-cis-4,4'-diapophytoene + 4 FAD = all-trans-4,4'-diapolycopene + 4 FADH2 (overall reaction);;(1a) 15-cis-4,4'-diapophytoene + FAD = all-trans-4,4'-diapophytofluene + FADH2;;(1b) all-trans-4,4'-diapophytofluene + FAD = all-trans-4,4'-diapo-zeta-carotene + FADH2;;(1c) all-trans-4,4'-diapo-zeta-carotene + FAD = all-trans-4,4'-diaponeurosporene + FADH2;;(1d) all-trans-4,4'-diaponeurosporene + FAD = all-trans-4,4'-diapolycopene + FADH2 | 15-cis-4,4'-diapophytoene:FAD oxidoreductase (4,4'-diapolycopene-forming) | None | dehydrosqualene desaturase (ambiguous); CrtN (ambiguous); 4,4'-diapophytoene:FAD oxidoreductase (ambiguous); 15-cis-4,4'-diapophytoene:FAD oxidoreductase; 4,4'-diapophytoene desaturase (ambiguous) | |
| 1.5.1.37 | FAD reductase (NADH) | False | 6 | 63 | 0 | 8 | FADH2 + NAD+ = FAD + NADH + H+ | FADH2:NAD+ oxidoreductase | None | NADH-FAD reductase; NADH-dependent FAD reductase; NADH:FAD oxidoreductase; NADH:flavin adenine dinucleotide oxidoreductase | |
| 1.5.1.38 | FMN reductase (NADPH) | False | 10 | 3913 | 9 | 3 | FMNH2 + NADP+ = FMN + NADPH + H+ | FMNH2:NADP+ oxidoreductase | None | FRP; flavin reductase P; SsuE | |
| 1.5.1.39 | FMN reductase [NAD(P)H] | False | 5 | 653 | 0 | 2 | FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+ | FMNH2:NAD(P)+ oxidoreductase | None | FRG | |
| 1.5.1.40 | 8-hydroxy-5-deazaflavin:NADPH oxidoreductase | False | 5 | 91 | 0 | 15 | reduced coenzyme F420 + NADP+ = oxidized coenzyme F420 + NADPH + H+ | reduced coenzyme F420:NADP+ oxidoreductase | None | 8-OH-5dFl:NADPH oxidoreductase | |
| 1.5.1.41 | riboflavin reductase [NAD(P)H] | False | 4 | 414 | 0 | 3 | reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + H+ | riboflavin:NAD(P)+ oxidoreductase | None | NAD(P)H-FMN reductase (ambiguous); NAD(P)H-dependent FMN reductase (ambiguous); NAD(P)H:FMN oxidoreductase (ambiguous); NAD(P)H:flavin oxidoreductase (ambiguous); NAD(P)H2 dehydrogenase (FMN) (ambiguous); NAD(P)H2:FMN oxidoreductase (ambiguous); riboflavin mononucleotide reductase (ambiguous); flavine mononucleotide reductase (ambiguous); riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase; flavin mononucleotide reductase (ambiguous); riboflavine mononucleotide reductase (ambiguous); Fre | |
| 1.5.1.42 | FMN reductase (NADH) | False | 75 | 1349 | 3 | 6 | FMNH2 + NAD+ = FMN + NADH + H+ | FMNH2:NAD+ oxidoreductase | None | NADH-FMN reductase; NADH-dependent FMN reductase; NADH:FMN oxidoreductase; NADH:flavin oxidoreductase | |
| 1.7.6.1 | nitrite dismutase | False | 2 | 0 | 9 | 1 | 3 nitrite + 2 H+ = 2 nitric oxide + nitrate + H2O | nitrite:nitrite oxidoreductase | None | Prolixin S; Nitrophorin 7 | |
| 2.1.1.211 | tRNASer (uridine44-2'-O)-methyltransferase | False | 18 | 3153 | 0 | 1 | S-adenosyl-L-methionine + uridine44 in tRNASer = S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer | S-adenosyl-L-methionine:tRNASer (uridine44-2'-O)-methyltransferase | None | TRM44 | |
| 2.1.1.212 | 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase | False | 3 | 3 | 0 | 6 | S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone | S-adenosyl-L-methionine:2,4',7-trihydroxyisoflavanone 4'-O-methyltransferase | None | SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase; HI4'OMT; HMM1; MtIOMT5; S-adenosyl-L-methionine:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase | |
| 2.1.1.213 | tRNA (guanine10-N2)-dimethyltransferase | False | 5 | 143 | 0 | 1 | 2 S-adenosyl-L-methionine + guanine10 in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction);;(1a) S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA;;(1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA = S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA | S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase | None | PAB1283; N(2),N(2)-dimethylguanosine tRNA methyltransferase; Trm-G10; PabTrm-G10; PabTrm-m2 2G10 enzyme | |
| 2.1.1.214 | tRNA (guanine10-N2)-methyltransferase | False | 2 | 36 | 0 | 2 | S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA | S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase | None | (m2G10) methyltransferase; Trm11-Trm112 complex | |
| 2.1.1.215 | tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase | False | 1 | 35 | 0 | 2 | 4 S-adenosyl-L-methionine + guanine26/guanine27 in tRNA = 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26/N2-dimethylguanine27 in tRNA | S-adenosyl-L-methionine:tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase | None | Trm1 (ambiguous); tRNA (N2,N2-guanine)-dimethyltransferase; tRNA (m2(2G26) methyltransferase; Trm1[tRNA (m2(2)G26) methyltransferase] | |
| 2.1.1.216 | tRNA (guanine26-N2)-dimethyltransferase | False | 61 | 8453 | 0 | 6 | 2 S-adenosyl-L-methionine + guanine26 in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA | S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase | None | Trm1p; TRM1; tRNA (m22G26)dimethyltransferase | |
| 2.1.1.217 | tRNA (adenine22-N1)-methyltransferase | False | 1 | 783 | 5 | 5 | S-adenosyl-L-methionine + adenine22 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase | None | TrmK; YqfN; Sp1610 (gene name); tRNA: m1A22 methyltransferase | |
| 2.1.1.218 | tRNA (adenine9-N1)-methyltransferase | False | 7 | 693 | 7 | 4 | S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA | S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase | None | Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; TK0422p (gene name); tRNA m1A9-methyltransferase; tRNA m1A9 Mtase | |
| 2.1.1.219 | tRNA (adenine57-N1/adenine58-N1)-methyltransferase | False | 2 | 262 | 0 | 1 | 2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA = 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA | S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase | None | TrmI; PabTrmI; AqTrmI; MtTrmI | |
| 2.1.1.220 | tRNA (adenine58-N1)-methyltransferase | False | 22 | 11045 | 7 | 7 | S-adenosyl-L-methionine + adenine58 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA | S-adenosyl-L-methionine:tRNA (adenine58-N1)-methyltransferase | None | tRNA m1A58 methyltransferase; tRNA (m1A58) methyltransferase; TrmI; tRNA (m1A58) Mtase; Rv2118cp; Gcd10p-Gcd14p; Trm61p-Trm6p | |
| 2.1.1.221 | tRNA (guanine9-N1)-methyltransferase | False | 30 | 6068 | 4 | 4 | S-adenosyl-L-methionine + guanine9 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA | S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase | None | Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; tRNA (guanine-N(1)-)-methyltransferase; tRNA m1G9-methyltransferase; tRNA m1G9 MTase | |
| 2.1.1.222 | 2-polyprenyl-6-hydroxyphenol methylase | False | 244 | 14932 | 1 | 5 | S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol | S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase | None | ubiG (gene name, ambiguous); ubiG methyltransferase (ambiguous); 2-octaprenyl-6-hydroxyphenol methylase | |
| 2.1.1.223 | tRNA1Val (adenine37-N6)-methyltransferase | False | 128 | 6067 | 0 | 1 | S-adenosyl-L-methionine + adenine37 in tRNA1Val = S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1Val | S-adenosyl-L-methionine:tRNA1Val (adenine37-N6)-methyltransferase | None | YfiC | |
| 2.1.1.224 | 23S rRNA (adenine2503-C8)-methyltransferase | False | 11 | 228 | 0 | 12 | 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin | S-adenosyl-L-methionine:23S rRNA (adenine2503-C8)-methyltransferase | None | Cfr (gene name) | |
| 2.1.1.225 | tRNA:m4X modification enzyme | False | 12 | 2970 | 0 | 1 | (1) S-adenosyl-L-methionine + cytidine4 in tRNAPro = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro;;(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC);;(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis | S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase | None | TRM13; Trm13p; tRNA:Xm4 modification enzyme | |
| 2.1.1.226 | 23S rRNA (cytidine1920-2'-O)-methyltransferase | False | 3 | 1512 | 4 | 7 | S-adenosyl-L-methionine + cytidine1920 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (cytidine1920-2'-O)-methyltransferase | None | TlyA (ambiguous) | |
| 2.1.1.227 | 16S rRNA (cytidine1409-2'-O)-methyltransferase | False | 2 | 705 | 0 | 4 | S-adenosyl-L-methionine + cytidine1409 in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase | None | TlyA (ambiguous) | |
| 2.1.1.228 | tRNA (guanine37-N1)-methyltransferase | False | 705 | 45539 | 134 | 18 | S-adenosyl-L-methionine + guanine37 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | S-adenosyl-L-methionine:tRNA (guanine37-N1)-methyltransferase | None | TrmD; tRNA (m1G37) methyltransferase; transfer RNA (m1G37) methyltransferase; Trm5p; TRMT5; tRNA-(N1G37) methyltransferase; MJ0883 (gene name) | |
| 2.1.1.229 | tRNA (carboxymethyluridine34-5-O)-methyltransferase | False | 8 | 863 | 0 | 5 | S-adenosyl-L-methionine + carboxymethyluridine34 in tRNA = S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA | S-adenosyl-L-methionine:tRNA (carboxymethyluridine34-5-O)-methyltransferase | None | ALKBH8; ABH8; Trm9; tRNA methyltransferase 9 | |
| 2.1.1.230 | 23S rRNA (adenosine1067-2'-O)-methyltransferase | False | 3 | 69 | 0 | 2 | S-adenosyl-L-methionine + adenosine1067 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase | None | 23S rRNA A1067 2'-methyltransferase; thiostrepton-resistance methylase; nosiheptide-resistance methyltransferase | |
| 2.4.1.271 | crocetin glucosyltransferase | False | 3 | 17 | 0 | 9 | (1) UDP-alpha-D-glucose + crocetin = UDP + beta-D-glucosyl crocetin;;(2) UDP-alpha-D-glucose + beta-D-glucosyl crocetin = UDP + bis(beta-D-glucosyl) crocetin;;(3) UDP-alpha-D-glucose + beta-D-gentiobiosyl crocetin = UDP + beta-D-gentiobiosyl beta-D-glucosyl crocetin | UDP-alpha-D-glucose:crocetin 8-O-D-glucosyltransferase | None | crocetin GTase; UGTCs2; UGT75L6; UDP-glucose:crocetin glucosyltransferase; UDP-glucose:crocetin 8-O-D-glucosyltransferase | |
| 2.4.1.272 | soyasapogenol B glucuronide galactosyltransferase | False | 1 | 26 | 0 | 1 | UDP-alpha-D-galactose + soyasapogenol B 3-O-beta-D-glucuronide = UDP + soyasaponin III | UDP-alpha-D-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase | None | UDP-galactose:SBMG-galactosyltransferase; UGT73P2; GmSGT2 (gene name); UDP-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase | |
| 2.4.1.273 | soyasaponin III rhamnosyltransferase | False | 1 | 54 | 0 | 1 | UDP-beta-L-rhamnose + soyasaponin III = UDP + soyasaponin I | UDP-beta-L-rhamnose:soyasaponin III rhamnosyltransferase | None | UGT91H4; GmSGT3 (gene name); UDP-rhamnose:soyasaponin III rhamnosyltransferase | |
| 2.4.1.274 | glucosylceramide beta-1,4-galactosyltransferase | False | 7 | 9 | 0 | 4 | UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase | None | lactosylceramide synthase; uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase; UDP-Gal:glucosylceramide beta1->4galactosyltransferase; GalT-2 (misleading); UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase | |
| 2.4.1.275 | neolactotriaosylceramide beta-1,4-galactosyltransferase | False | 14 | 142 | 0 | 3 | UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase | None | beta4Gal-T4; UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase; lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect) | |
| 2.8.1.9 | molybdenum cofactor sulfurtransferase | False | 38 | 2583 | 0 | 2 | molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor | L-cysteine:molybdenum cofactor sulfurtransferase | None | molybdenum cofactor sulfurase; ABA3; HMCS; MoCo sulfurase; MoCo sulfurtransferase | |
| 3.2.1.176 | cellulose 1,4-beta-cellobiosidase (reducing end) | False | 2 | 119 | 18 | 38 | Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and similar substrates, releasing cellobiose from the reducing ends of the chains. | 4-beta-D-glucan cellobiohydrolase (reducing end) | None | CelS; CelSS; endoglucanase SS; cellulase SS; cellobiohydrolase CelS; Cel48A | |
| 3.2.1.177 | alpha-D-xyloside xylohydrolase | False | 8 | 3436 | 3 | 8 | Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. | alpha-D-xyloside xylohydrolase | None | alpha-xylosidase | |
| 3.2.1.178 | beta-porphyranase | False | 7 | 83 | 3 | 2 | Hydrolysis of beta-D-galactopyranose-(1->4)-alpha-L-galactopyranose-6-sulfate linkages in porphyran | porphyran beta-D-galactopyranose-(1->4)-alpha-L-galactopyranose-6-sulfate 4-glycanohydrolase | None | porphyranase; PorA; PorB; endo-beta-porphyranase | |
| 3.4.11.26 | intermediate cleaving peptidase 55 | False | 2 | 41 | 3 | 2 | The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase. | None | None | Icp55; mitochondrial intermediate cleaving peptidase 55 kDa | |
| 3.7.1.14 | 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase | False | 22 | 974 | 0 | 1 | (1) (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + succinate;;(2) (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate | (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase | None | mhpC (gene name) | |
| 4.1.1.93 | pyrrole-2-carboxylate decarboxylase | False | 1 | 265 | 0 | 1 | (1) pyrrole-2-carboxylate = pyrrole + CO2;;(2) pyrrole-2-carboxylate + H2O = pyrrole + HCO3- | pyrrole-2-carboxylate carboxy-lyase | None | None | |
| 4.1.2.48 | low-specificity L-threonine aldolase | False | 11 | 8989 | 4 | 10 | (1) L-threonine = glycine + acetaldehyde;;(2) L-allo-threonine = glycine + acetaldehyde | L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming) | None | LtaE | |
| 4.1.2.49 | L-allo-threonine aldolase | False | 2 | 374 | 2 | 1 | L-allo-threonine = glycine + acetaldehyde | L-allo-threonine acetaldehyde-lyase (glycine-forming) | None | None | |
| 4.1.99.17 | phosphomethylpyrimidine synthase | False | 439 | 25263 | 7 | 8 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO | 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine-forming) | None | thiC (gene name) | |
| 4.1.99.19 | 2-iminoacetate synthase | False | 2 | 2250 | 0 | 2 | L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+ | L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming) | None | thiH (gene name) | |
| 4.2.1.130 | D-lactate dehydratase | False | 14 | 19775 | 7 | 7 | (R)-lactate = 2-oxopropanal + H2O | (R)-lactate hydro-lyase | None | glyoxylase III; GLO3 | |
| 4.2.2.25 | gellan lyase | False | 2 | 36 | 0 | 3 | Eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end. The tetrasaccharide produced from deacetylated gellan is beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. | gellan beta-D-glucopyranosyl-(1->4)-D-glucopyranosyluronate lyase | None | None | |
| 4.2.3.78 | beta-chamigrene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate | (2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-beta-chamigrene-forming) | None | None | |
| 4.2.3.79 | thujopsene synthase | False | 2 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate | (2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-thujopsene-forming) | None | None | |
| 4.2.3.80 | alpha-longipinene synthase | False | 1 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-longipinene-forming) | None | None | |
| 4.2.3.81 | exo-alpha-bergamotene synthase | False | 10 | 8 | 1 | 6 | (2E,6E)-farnesyl diphosphate = (-)-exo-alpha-bergamotene + diphosphate | (2E,6E)-farnesyl diphosphate lyase (cyclizing, (-)-exo-alpha-bergamotene-forming) | None | trans-alpha-bergamotene synthase; LaBERS (gene name) | |
| 4.2.3.82 | alpha-santalene synthase | False | 3 | 0 | 0 | 4 | (2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate | (2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-alpha-santalene-forming) | None | None | |
| 4.2.3.83 | beta-santalene synthase | False | 3 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate | (2E,6E)-farnesyl diphosphate lyase (cyclizing, (-)-beta-santalene-forming) | None | None | |
| 4.3.3.6 | pyridoxal 5'-phosphate synthase (glutamine hydrolysing) | False | 461 | 29338 | 16 | 10 | D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate | D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase | None | PdxST | |
| 5.1.3.24 | N-acetylneuraminate epimerase | False | 41 | 1046 | 0 | 1 | N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate (oveall reaction);;(1a) N-acetyl-alpha-neuraminate = aceneuramate;;(1b) aceneuramate = N-acetyl-beta-neuraminate | N-acetyl-alpha-neuraminate 2-epimerase | None | sialic acid epimerase; N-acetylneuraminate mutarotase; NanM; NanQ | |
| 5.4.99.42 | tRNA pseudouridine31 synthase | False | 1 | 1 | 0 | 1 | tRNA uridine31 = tRNA pseudouridine31 | tRNA-uridine31 uracil mutase | None | Pus6p | |
| 5.4.99.43 | 21S rRNA pseudouridine2819 synthase | False | 6 | 300 | 0 | 1 | 21S rRNA uridine2819 = 21S rRNA pseudouridine2819 | 21S rRNA-uridine2819 uracil mutase | None | Pus5p | |
| 5.4.99.44 | mitochondrial tRNA pseudouridine27/28 synthase | False | 1 | 3 | 0 | 1 | mitochondrial tRNA uridine27/28 = mitochondrial tRNA pseudouridine27/28 | mitochondrial tRNA-uridine27/28 uracil mutase | None | Pus2; Pus2p; RNA:pseudouridine synthases 2 | |
| 5.5.1.18 | lycopene epsilon-cyclase | False | 3 | 16 | 0 | 13 | carotenoid psi-end group = carotenoid epsilon-end group | carotenoid psi-end group lyase (ring-opening) | None | CrtL-e; LCYe; carotenoid psi-end group lyase (decyclizing) | |
| 5.5.1.19 | lycopene beta-cyclase | False | 32 | 2197 | 0 | 31 | carotenoid psi-end group = carotenoid beta-end group | carotenoid beta-end group lyase (ring-opening) | None | CrtL; CrtL-b; CrtY; LCYb; carotenoid beta-end group lyase (decyclizing) | |
| 5.3.2.3 | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming) | False | 1 | 195 | 0 | 3 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase | None | dTDP-6-deoxy-hex-4-ulose isomerase; TDP-6-deoxy-hex-4-ulose isomerase; FdtA | |
| 1.1.1.315 | 11-cis-retinol dehydrogenase | False | 6 | 3 | 0 | 3 | 11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+ | 11-cis-retinol:NAD+ oxidoreductase | None | RDH5 (gene name) | |
| 1.2.1.82 | beta-apo-4'-carotenal dehydrogenase | False | 2 | 0 | 0 | 2 | 4'-apo-beta,psi-caroten-4'-al + NAD+ + H2O = neurosporaxanthin + NADH + 2 H+ | 4'-apo-beta,psi-carotenal:NAD+ oxidoreductase | None | beta-apo-4'-carotenal oxygenase; YLO-1; carD (gene name) | |
| 1.4.9.1 | methylamine dehydrogenase (amicyanin) | False | 10 | 548 | 9 | 7 | methylamine + H2O + 2 amicyanin = formaldehyde + NH3 + 2 reduced amicyanin | methylamine:amicyanin oxidoreductase (deaminating) | None | amine dehydrogenase; primary-amine dehydrogenase; amine: (acceptor) oxidoreductase (deaminating); primary-amine:(acceptor) oxidoreductase (deaminating) | |
| 1.4.9.2 | aralkylamine dehydrogenase (azurin) | False | 2 | 120 | 0 | 5 | ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin | aralkylamine:azurin oxidoreductase (deaminating) | None | aromatic amine dehydrogenase; arylamine dehydrogenase; tyramine dehydrogenase; aralkylamine:(acceptor) oxidoreductase (deaminating) | |
| 1.6.5.10 | NADPH dehydrogenase (quinone) | False | 11 | 79 | 0 | 17 | NADPH + H+ + a quinone = NADP+ + a quinol | NADPH:(quinone-acceptor) oxidoreductase | None | reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase; NADPH oxidase; NADPH2 dehydrogenase (quinone) | |
| 1.13.11.59 | torulene dioxygenase | False | 3 | 4 | 0 | 2 | torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal | torulene:oxygen oxidoreductase | None | CAO-2; CarT | |
| 1.13.12.19 | 2-oxoglutarate dioxygenase (ethene-forming) | False | 6 | 9094 | 17 | 4 | 2-oxoglutarate + O2 = ethene + 3 CO2 + H2O | 2-oxoglutarate:oxygen oxidoreductase (decarboxylating, ethene-forming) | None | ethylene-forming enzyme; EFE; 2-oxoglutarate dioxygenase (ethylene-forming); 2-oxoglutarate:oxygen oxidoreductase (decarboxylating, ethylene-forming) | |
| 1.14.13.131 | dissimilatory dimethyl sulfide monooxygenase | False | 1 | 329 | 1 | 2 | dimethyl sulfide + O2 + NADH + H+ = methanethiol + formaldehyde + NAD+ + H2O | dimethyl sulfide,NADH:oxygen oxidoreductase | None | dmoAB (gene names); dimethyl sulfide C-monooxygenase; dimethylsulfide monooxygenase (ambiguous); dimethyl sulfide monooxygenase (ambiguous) | |
| 1.14.14.9 | 4-hydroxyphenylacetate 3-monooxygenase | False | 8 | 2039 | 4 | 10 | 4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O | 4-hydroxyphenylacetate,FADH2:oxygen oxidoreductase (3-hydroxylating) | None | p-hydroxyphenylacetate 3-hydroxylase; 4-hydroxyphenylacetic acid-3-hydroxylase; p-hydroxyphenylacetate hydroxylase (FAD); 4 HPA 3-hydroxylase; p-hydroxyphenylacetate 3-hydroxylase (FAD); HpaB | |
| 1.20.9.1 | arsenate reductase (azurin) | False | 4 | 916 | 4 | 12 | arsenite + H2O + 2 oxidized azurin = arsenate + 2 reduced azurin + 2 H+ | arsenite:azurin oxidoreductase | None | arsenite oxidase (ambiguous) | |
| 2.1.1.231 | flavonoid 4'-O-methyltransferase | False | 1 | 0 | 0 | 4 | S-adenosyl-L-methionine + a 4'-hydroxyflavanone = S-adenosyl-L-homocysteine + a 4'-methoxyflavanone | S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase | None | SOMT-2; 4'-hydroxyisoflavone methyltransferase | |
| 2.1.1.232 | naringenin 7-O-methyltransferase | False | 5 | 0 | 0 | 3 | S-adenosyl-L-methionine + (2S)-naringenin = S-adenosyl-L-homocysteine + (2S)-sakuranetin | S-adenosyl-L-methionine:(2S)-5,7,4'-trihydroxyflavanone 7-O-methyltransferase | None | NOMT | |
| 2.4.1.276 | zeaxanthin glucosyltransferase | False | 2 | 80 | 0 | 4 | 2 UDP-glucose + zeaxanthin = 2 UDP + zeaxanthin bis(beta-D-glucoside) | UDP-glucose:zeaxanthin beta-D-glucosyltransferase | None | crtX (gene name) | |
| 2.5.1.96 | 4,4'-diapophytoene synthase | False | 11 | 311 | 8 | 8 | 2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate (overall reaction);;(1a) 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate;;(1b) presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate | farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (15-cis-4,4'-diapophytoene-forming) | None | dehydrosqualene synthase; DAP synthase; C30 carotene synthase; CrtM | |
| 2.8.1.10 | thiazole synthase | False | 399 | 24558 | 1 | 8 | 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O | 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase | None | thiG (gene name) | |
| 3.1.4.54 | N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | False | 8 | 854 | 4 | 4 | N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate | N-acetylphosphatidylethanolamine phosphatidohydrolase | None | NAPE-PLD; anandamide-generating phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; NAPE-hydrolyzing phospholipase D | |
| 4.2.1.131 | carotenoid 1,2-hydratase | False | 4 | 73 | 0 | 9 | (1) 1-hydroxy-1,2-dihydrolycopene = lycopene + H2O;;(2) 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = 1-hydroxy-1,2-dihydrolycopene + H2O | lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming) | None | CrtC | |
| 4.2.3.84 | 10-epi-gamma-eudesmol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (10-epi-gamma-eudesmol-forming) | None | None | |
| 4.2.3.85 | alpha-eudesmol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-eudesmol-forming) | None | None | |
| 5.4.99.45 | tRNA pseudouridine38/39 synthase | False | 4 | 65 | 6 | 2 | tRNA uridine38/39 = tRNA pseudouridine38/39 | tRNA-uridine38/39 uracil mutase | None | Deg1; Pus3p; pseudouridine synthase 3 | |
| 1.1.1.316 | L-galactose 1-dehydrogenase | False | 1 | 48 | 2 | 10 | L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ | L-galactose:NAD+ 1-oxidoreductase | None | L-GalDH; L-galactose dehydrogenase | |
| 1.1.1.317 | perakine reductase | False | 1 | 207 | 0 | 1 | raucaffrinoline + NADP+ = perakine + NADPH + H+ | raucaffrinoline:NADP+ oxidoreductase | None | None | |
| 1.1.3.42 | prosolanapyrone-II oxidase | False | 1 | 9 | 0 | 2 | prosolanapyrone II + O2 = prosolanapyrone III + H2O2 | prosolanapyrone-II:oxygen 3'-oxidoreductase | None | Sol5 (ambiguous); SPS (ambiguous); solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cycloisomerase); prosolanapyrone II oxidase | |
| 1.1.9.1 | alcohol dehydrogenase (azurin) | False | 3 | 264 | 0 | 2 | a primary alcohol + azurin = an aldehyde + reduced azurin | alcohol:azurin oxidoreductase | None | type II quinoprotein alcohol dehydrogenase; quinohaemoprotein ethanol dehydrogenase; QHEDH; ADHIIB | |
| 1.13.11.60 | linoleate 8R-lipoxygenase | False | 6 | 606 | 0 | 7 | linoleate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate | linoleate:oxygen (8R)-oxidoreductase | None | linoleic acid 8R-dioxygenase; 5,8-LDS (bifunctional enzyme); 7,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 7,8-linoleate diol synthase (bifunctional enzyme); PpoA | |
| 1.13.11.61 | linolenate 9R-lipoxygenase | False | 1 | 6 | 0 | 3 | alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate | alpha-linolenate:oxygen (9R)-oxidoreductase | None | NspLOX; (9R)-LOX; linoleate 9R-dioxygenase | |
| 1.13.11.62 | linoleate 10R-lipoxygenase | False | 3 | 6 | 0 | 3 | linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate | linoleate:oxygen (10R)-oxidoreductase | None | 10R-DOX; (10R)-dioxygenase; 10R-dioxygenase | |
| 1.14.13.135 | 1-hydroxy-2-naphthoate hydroxylase | True | 0 | 0 | 0 | 2 | 1-hydroxy-2-naphthoate + NAD(P)H + H+ + O2 = 1,2-dihydroxynaphthalene + NAD(P)+ + H2O + CO2 | 1-hydroxy-2-naphthoate,NAD(P)H:oxygen oxidoreductase (2-hydroxylating, decarboxylating) | None | 1-hydroxy-2-naphthoic acid hydroxylase | |
| 1.14.14.11 | styrene monooxygenase | False | 2 | 86 | 0 | 7 | styrene + FADH2 + O2 = (S)-2-phenyloxirane + FAD + H2O | styrene,FADH2:oxygen oxidoreductase | None | StyA; SMO; NSMOA | |
| 1.14.14.12 | 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase | False | 3 | 690 | 0 | 1 | 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O | 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase | None | HsaA | |
| 1.16.9.1 | iron:rusticyanin reductase | True | 0 | 0 | 0 | 1 | Fe(II) + rusticyanin = Fe(III) + reduced rusticyanin | Fe(II):rusticyanin oxidoreductase | None | Cyc2 (ambiguous) | |
| 1.17.7.2 | 7-hydroxymethyl chlorophyll a reductase | False | 2 | 4 | 1 | 2 | chlorophyll a + H2O + 2 oxidized ferredoxin = 71-hydroxychlorophyll a + 2 reduced ferredoxin + 2 H+ | chlorophyll-a:ferredoxin oxidoreductase | None | HCAR; 71-hydroxychlorophyll-a:ferredoxin oxidoreductase | |
| 2.1.1.234 | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | False | 1 | 245 | 0 | 1 | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose | S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase | None | DesVI | |
| 2.1.1.235 | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | False | 1 | 74 | 5 | 1 | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose | S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase | None | TylM1 | |
| 2.1.1.236 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase | True | 0 | 0 | 0 | 2 | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose | S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase | None | RavNMT | |
| 2.1.1.237 | mycinamicin III 3''-O-methyltransferase | False | 1 | 33 | 9 | 1 | S-adenosyl-L-methionine + mycinamicin III = S-adenosyl-L-homocysteine + mycinamicin IV | S-adenosyl-L-methionine:mycinamicin III 3''-O-methyltransferase | None | MycF | |
| 2.1.1.238 | mycinamicin VI 2''-O-methyltransferase | False | 1 | 27 | 0 | 1 | S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III | S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase | None | MycE | |
| 2.4.1.277 | 10-deoxymethynolide desosaminyltransferase | False | 1 | 5 | 0 | 1 | dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin | dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase | None | glycosyltransferase DesVII; DesVII | |
| 2.5.1.97 | pseudaminic acid synthase | False | 3 | 2006 | 1 | 2 | phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H2O = 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate | phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transfering, 2-carboxy-2-oxoethyl-forming) | None | PseI; NeuB3 | |
| 2.6.1.88 | methionine transaminase | False | 4 | 862 | 0 | 5 | L-methionine + a 2-oxo carboxylate = 4-(methylsulfanyl)-2-oxobutanoate + an L-amino acid | L-methionine:2-oxo-acid aminotransferase | None | methionine-oxo-acid transaminase | |
| 2.6.1.89 | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase | True | 0 | 0 | 0 | 1 | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase | None | TylB; TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase; TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase; dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase; dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase | |
| 2.6.1.90 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase | False | 1 | 478 | 0 | 2 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase | None | dTDP-6-deoxy-D-xylohex-3-uloseaminase; FdtB; TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase; RavAMT; TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase; TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase | |
| 2.6.1.92 | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase | False | 3 | 2277 | 0 | 2 | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate transaminase | None | PseC; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate aminotransferase; UDP-beta-L-threo-pentapyranos-4-ulose transaminase; UDP-4-dehydro-6-deoxy-D-glucose transaminase | |
| 2.7.7.80 | molybdopterin-synthase adenylyltransferase | False | 45 | 3259 | 2 | 2 | ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP | ATP:molybdopterin-synthase adenylyltransferase | None | MoeB; adenylyltransferase and sulfurtransferase MOCS3 | |
| 2.8.1.11 | molybdopterin synthase sulfurtransferase | False | 37 | 1638 | 0 | 3 | [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + [cysteine desulfurase]-L-cysteine + oxidized acceptor | [cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase | None | adenylyltransferase and sulfurtransferase MOCS3; Cnx5 (gene name); molybdopterin synthase sulfurylase | |
| 2.8.1.12 | molybdopterin synthase | False | 78 | 17836 | 5 | 9 | cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O = molybdopterin + 2 molybdopterin-synthase sulfur-carrier protein | thiocarboxylated molybdopterin synthase:cyclic pyranopterin phosphate sulfurtransferase | None | MPT synthase | |
| 3.1.1.89 | protein phosphatase methylesterase-1 | False | 22 | 998 | 0 | 6 | [phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol | [phosphatase 2A protein]-leucine ester acylhydrolase | None | PME-1; PPME1 | |
| 3.1.1.90 | all-trans-retinyl ester 13-cis isomerohydrolase | False | 2 | 0 | 0 | 2 | an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid | all-trans-retinyl ester acylhydrolase, 13-cis-retinol-forming | None | None | |
| 3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | False | 29 | 2372 | 107 | 6 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | None | SHIP1; SHIP2; SHIP; p150Ship | |
| 3.2.1.179 | gellan tetrasaccharide unsaturated glucuronosyl hydrolase | False | 1 | 315 | 0 | 3 | beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp | beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp beta-D-4-deoxy-Delta4-GlcAp hydrolase | None | UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous); gellan tetrasaccharide unsaturated glucuronyl hydrolase | |
| 3.2.1.180 | unsaturated chondroitin disaccharide hydrolase | False | 3 | 287 | 1 | 6 | beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate | beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase | None | UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous) | |
| 3.4.19.13 | glutathione gamma-glutamate hydrolase | False | 33 | 34210 | 5 | 22 | (1) glutathione + H2O = L-cysteinylglycine + L-glutamate;;(2) a glutathione-S-conjugate + H2O = an (L-cysteinylglycine)-S-conjugate + L-glutamate | None | None | glutathionase; gamma-glutamyltranspeptidase (ambiguous); glutathione hydrolase; GGT (gene name); ECM38 (gene name) | |
| 3.5.1.109 | sphingomyelin deacylase | False | 1 | 0 | 0 | 1 | (1) an N-acyl-sphingosylphosphorylcholine + H2O = a fatty acid + sphingosylphosphorylcholine;; (2) a D-glucosyl-N-acylsphingosine + H2O = a fatty acid + D-glucosyl-sphingosine | N-acyl-sphingosylphosphorylcholine amidohydrolase | None | SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase | |
| 3.6.1.55 | 8-oxo-dGTP diphosphatase | False | 15 | 28100 | 133 | 7 | 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate | 8-oxo-dGTP diphosphohydrolase | None | MutT; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase | |
| 3.6.1.56 | 2-hydroxy-dATP diphosphatase | False | 6 | 3260 | 0 | 4 | 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate | 2-hydroxy-dATP diphosphohydrolase | None | NUDT1; MTH1; MTH2; oxidized purine nucleoside triphosphatase; (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase | |
| 3.6.1.57 | UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase | False | 3 | 1406 | 0 | 2 | UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP | UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase | None | PseG; UDP-6-deoxy-AltdiNAc hydrolase; Cj1312; UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose hydrolase | |
| 4.2.3.86 | 7-epi-alpha-selinene synthase | False | 2 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = 7-epi-alpha-selinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-alpha-selinene-forming) | None | None | |
| 4.2.3.87 | alpha-guaiene synthase | False | 4 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate | (2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-guaiene-forming) | None | PatTps177 (gene name) | |
| 4.2.3.88 | viridiflorene synthase | False | 6 | 2 | 0 | 2 | (2E,6E)-farnesyl diphosphate = viridiflorene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (viridiflorene-forming) | None | TPS31 | |
| 4.2.3.89 | (+)-beta-caryophyllene synthase | False | 1 | 1 | 0 | 9 | (2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate | (2Z,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-beta-caryophyllene-forming] | None | GcoA | |
| 4.2.3.90 | 5-epi-alpha-selinene synthase | False | 1 | 7 | 0 | 2 | (2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 5-epi-alpha-selinene-forming) | None | 8a-epi-alpha-selinene synthase; NP1 | |
| 4.2.3.91 | cubebol synthase | False | 2 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, cubebol-forming) | None | Cop4 | |
| 4.2.3.92 | (+)-gamma-cadinene synthase | False | 3 | 2 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-gamma-cadinene-forming] | None | None | |
| 4.2.3.93 | delta-guaiene synthase | False | 4 | 1 | 0 | 1 | (2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, delta-guaiene-forming) | None | None | |
| 5.3.2.4 | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming) | True | 0 | 0 | 0 | 1 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase | None | TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous); Tyl1a; dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous) | |
| 5.3.3.18 | 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase | False | 1 | 2798 | 1 | 3 | 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA | 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase | None | paaG (gene name); 1,2-epoxyphenylacetyl-CoA isomerase (misleading) | |
| 5.4.4.5 | 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase | False | 4 | 3 | 0 | 3 | (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate | (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase [(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate-forming] | None | 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA | |
| 5.4.4.6 | 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase | False | 2 | 3 | 0 | 2 | (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate | (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase [(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming] | None | 8-hydroperoxide isomerase (ambiguous); (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming) | |
| 5.4.99.46 | shionone synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = shionone | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, shionone-forming) | None | None | |
| 5.4.99.47 | parkeol synthase | False | 1 | 0 | 0 | 5 | (3S)-2,3-epoxy-2,3-dihydrosqualene = parkeol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, parkeol-forming) | None | None | |
| 5.4.99.48 | achilleol B synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = achilleol B | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, achilleol-B-forming) | None | None | |
| 5.4.99.49 | glutinol synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = glutinol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, glutinol-forming) | None | None | |
| 5.4.99.50 | friedelin synthase | False | 1 | 0 | 0 | 2 | (3S)-2,3-epoxy-2,3-dihydrosqualene = friedelin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming) | None | None | |
| 5.4.99.51 | baccharis oxide synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = baccharis oxide | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baccharis-oxide-forming) | None | None | |
| 5.4.99.52 | alpha-seco-amyrin synthase | False | 1 | 1 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-seco-amyrin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-seco-amyrin-forming) | None | None | |
| 5.4.99.53 | marneral synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = marneral | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming) | None | None | |
| 5.4.99.54 | beta-seco-amyrin synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-seco-amyrin-forming) | None | None | |
| 5.4.99.55 | delta-amyrin synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, delta-amyrin-forming) | None | SlTTS2 (gene name) | |
| 5.4.99.56 | tirucalladienol synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3beta-ol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming) | None | PEN3 | |
| 5.5.1.20 | prosolanapyrone-III cycloisomerase | False | 1 | 11 | 0 | 3 | prosolanapyrone III = (-)-solanapyrone A | prosolanapyrone-III:(-)-solanapyrone A isomerase | None | Sol5 (ambiguous); SPS (ambiguous); solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase) | |
| 1.5.8.3 | sarcosine dehydrogenase | False | 3 | 147 | 0 | 10 | sarcosine + 5,6,7,8-tetrahydrofolate + oxidized [electron-transfer flavoprotein] = glycine + 5,10-methylenetetrahydrofolate + reduced [electron-transfer flavoprotein] | sarcosine, 5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming) | None | sarcosine N-demethylase; monomethylglycine dehydrogenase; sarcosine:(acceptor) oxidoreductase (demethylating); sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating) | |
| 1.5.8.4 | dimethylglycine dehydrogenase | False | 3 | 200 | 3 | 7 | N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein | N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming) | None | N,N-dimethylglycine oxidase; N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating); Me2GlyDH; N,N-dimethylglycine:electron-transfer flavoprotein oxidoreductase (demethylating) | |
| 1.14.13.146 | taxoid 14beta-hydroxylase | False | 1 | 1 | 0 | 2 | 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O | 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase | None | None | |
| 1.14.13.148 | trimethylamine monooxygenase | False | 22 | 2451 | 0 | 11 | N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O | N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming) | None | flavin-containing monooxygenase 3; FMO3; tmm (gene name) | |
| 1.14.13.149 | phenylacetyl-CoA 1,2-epoxidase | False | 1 | 6783 | 1 | 3 | phenylacetyl-CoA + NADPH + H+ + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O | phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing) | None | ring 1,2-phenylacetyl-CoA epoxidase; phenylacetyl-CoA monooxygenase; PaaAC; PaaABC(D)E | |
| 2.1.1.239 | L-olivosyl-oleandolide 3-O-methyltransferase | False | 1 | 1 | 0 | 1 | S-adenosyl-L-methionine + L-olivosyl-oleandolide = S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide | S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase | None | OleY | |
| 2.1.1.240 | trans-resveratrol di-O-methyltransferase | False | 1 | 37 | 0 | 4 | 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction);;(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene;;(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene | S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase | None | ROMT; resveratrol O-methyltransferase; pterostilbene synthase | |
| 2.1.1.241 | 2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside = S-adenosyl-L-homocysteine + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside | S-adenosyl-L-methionine:(2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside 7-O-methyltransferase | None | BX7 (gene name); OMT BX7 | |
| 2.1.1.242 | 16S rRNA (guanine1516-N2)-methyltransferase | False | 196 | 6138 | 0 | 1 | S-adenosyl-L-methionine + guanine1516 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1516 in 16S rRNA | S-adenosyl-L-methionine:16S rRNA (guanine1516-N2)-methyltransferase | None | yhiQ (gene name); rsmJ (gene name); m2G1516 methyltransferase | |
| 2.3.1.197 | dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase | False | 1 | 192 | 0 | 1 | acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose | acetyl-CoA:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase | None | FdtC; dTDP-D-Fucp3N acetylase | |
| 2.4.1.278 | 3-alpha-mycarosylerythronolide B desosaminyl transferase | False | 1 | 76 | 0 | 2 | dTDP-D-desosamine + 3-alpha-L-mycarosylerythronolide B = dTDP + erythromycin D | dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-3,4,6-trideoxy-beta-D-glucosyltransferase | None | EryCIII; dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase | |
| 2.5.1.98 | Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase | False | 1 | 43 | 0 | 1 | phosphoenolpyruvate + [beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-4,6-CH3(COO-)C-beta-D-Gal-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2(or 3)-O-Ac-alpha-D-Glc-(1->6)]n = [beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-4,6-CH3(COO-)C-beta-D-Gal-(1->3)-4,6-CH3(COO-)C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2(or 3)-O-Ac-alpha-D-Glc-(1->6)]n + phosphate | phosphoenolpyruvate:[beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-CH3-CH2CH(OH)C(O)-4,6-CH3(COO-)C-beta-D-Gal-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2(or 3)-O-Ac-alpha-D-Glc-(1->6)]n 4,6-O-(1-carboxyethan-1,1-diyl)transferase | None | PssM; phosphoenolpyruvate:[D-GlcA-beta-(1->4)-2-O-Ac-D-GlcA-beta-(1->4)-D-Glc-beta-(1->4)-[3-O-CH3-CH2CH(OH)C(O)-D-Gal-beta-(1->4)-D-Glc-beta-(1->4)-D-Glc-beta-(1->4)-D-Glc-beta-(1->6)]-2(or 3)-O-Ac-D-Glc-alpha-(1->6)]n 4,6-O-(1-carboxyethan-1,1-diyl)transferase | |
| 2.7.7.81 | pseudaminic acid cytidylyltransferase | False | 3 | 973 | 0 | 1 | CTP + 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid = diphosphate + CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid | CTP:5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid cytidylyltransferase | None | PseF | |
| 3.1.7.10 | (13E)-labda-7,13-dien-15-ol synthase | False | 1 | 1 | 0 | 1 | geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate | geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming] | None | labda-7,13E-dien-15-ol synthase | |
| 3.4.19.14 | leukotriene-C4 hydrolase | False | 8 | 25 | 0 | 2 | leukotriene C4 + H2O = leukotriene D4 + L-glutamate | None | None | gamma-glutamyl leukotrienase; GGT5 | |
| 3.5.4.32 | 8-oxoguanine deaminase | False | 1 | 3591 | 1 | 2 | 8-oxoguanine + H2O = urate + NH3 | 8-oxoguanine aminohydrolase | None | 8-OGD | |
| 3.6.1.58 | 8-oxo-dGDP phosphatase | False | 10 | 18 | 0 | 2 | (1) 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate;;(2) 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate | 8-oxo-dGDP phosphohydrolase | None | NUDT5; MTH3 (gene name); NUDT18 | |
| 3.6.1.59 | 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase | False | 13 | 1231 | 6 | 5 | a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA] | 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase | None | DcpS; m7GpppX pyrophosphatase; m7GpppN m7GMP phosphohydrolase; m7GpppX diphosphatase; m7G5'ppp5'N m7GMP phosphohydrolase | |
| 3.6.1.60 | diadenosine hexaphosphate hydrolase (AMP-forming) | False | 6 | 7 | 0 | 3 | (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-pentaphosphate + AMP;;(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP | P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming) | None | hAps1; NUDT11 (gene name); hAps2; NUDT10 (gene name) | |
| 3.6.1.61 | diadenosine hexaphosphate hydrolase (ATP-forming) | False | 7 | 248 | 0 | 2 | (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP;; (2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP;; (3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP | P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming) | None | Ndx1 | |
| 3.6.1.62 | 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase | False | 23 | 2687 | 44 | 7 | a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O = N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA] | 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase | None | Dcp2; NUDT16; D10 protein; D9 protein; D10 decapping enzyme; decapping enzyme; m7GpppN-mRNA hydrolase; m7GpppN-mRNA m7GDP phosphohydrolase | |
| 3.7.1.17 | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | False | 3 | 453 | 7 | 2 | (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming) | None | tesD (gene name); hsaD (gene name) | |
| 4.2.3.94 | gamma-curcumene synthase | False | 3 | 6 | 0 | 1 | (2E,6E)-farnesyl diphosphate = gamma-curcumene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, gamma-curcumene-forming) | None | PatTpsA (gene name) | |
| 4.2.3.95 | (-)-alpha-cuprenene synthase | True | 0 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate | (-)-alpha-cuprenene hydrolase [cyclizing, (-)-alpha-cuprenene-forming] | None | Cop6 | |
| 4.2.3.96 | avermitilol synthase | False | 1 | 2 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate | avermitilol hydrolase (cyclizing, avermitilol-forming) | None | None | |
| 4.2.3.97 | (-)-delta-cadinene synthase | False | 1 | 2 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-delta-cadinene-forming) | None | None | |
| 4.2.3.98 | (+)-T-muurolol synthase | False | 3 | 6 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming) | None | None | |
| 4.2.3.99 | labdatriene synthase | False | 1 | 0 | 0 | 1 | 9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate | 9alpha-copalyl-diphosphate diphosphate-lyase [(12E)-9alpha-labda-8(17),12,14-triene-forming] | None | OsKSL10 (gene name) | |
| 4.2.3.100 | bicyclogermacrene synthase | False | 5 | 5 | 0 | 2 | (2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming) | None | Ov-TPS4 | |
| 4.2.3.101 | 7-epi-sesquithujene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-sesquithujene-forming) | None | TPS4-B73 | |
| 4.2.3.102 | sesquithujene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = sesquithujene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (sesquithujene-forming) | None | TPS5-Del1 | |
| 4.2.3.103 | ent-isokaurene synthase | False | 2 | 0 | 0 | 2 | ent-copalyl diphosphate = ent-isokaurene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-isokaurene-forming) | None | OsKSL5i; OsKSL6 | |
| 4.2.3.104 | alpha-humulene synthase | False | 13 | 1 | 3 | 7 | (2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-humulene-forming) | None | ZSS1 | |
| 5.4.99.57 | baruol synthase | False | 1 | 0 | 0 | 1 | (3S)-2,3-epoxy-2,3-dihydrosqualene = baruol | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baruol-forming) | None | BARS1 | |
| 1.1.1.318 | eugenol synthase | False | 4 | 15 | 0 | 14 | eugenol + a carboxylate + NADP+ = a coniferyl ester + NADPH + H+ | eugenol:NADP+ oxidoreductase (coniferyl ester reducing) | None | LtCES1; EGS1; EGS2 | |
| 1.1.1.319 | isoeugenol synthase | False | 2 | 3 | 0 | 5 | isoeugenol + acetate + NADP+ = coniferyl acetate + NADPH + H+ | eugenol:NADP+ oxidoreductase (coniferyl acetate reducing) | None | IGS1; t-anol/isoeugenol synthase 1 | |
| 1.1.1.320 | benzil reductase [(S)-benzoin forming] | False | 4 | 388 | 0 | 2 | (S)-benzoin + NADP+ = benzil + NADPH + H+ | (S)-benzoin:NADP+ oxidoreductase | None | YueD | |
| 1.1.1.321 | benzil reductase [(R)-benzoin forming] | True | 0 | 0 | 0 | 1 | (R)-benzoin + NADP+ = benzil + NADPH + H+ | (R)-benzoin:NADP+ oxidoreductase | None | None | |
| 1.1.1.322 | (-)-endo-fenchol dehydrogenase | True | 0 | 0 | 0 | 1 | (-)-endo-fenchol + NAD(P)+ = (+)-fenchone + NAD(P)H + H+ | (-)-endo-fenchol:NAD(P)+ oxidoreductase | None | l-endo-fenchol dehydrogenase; FDH | |
| 1.1.1.323 | (+)-thujan-3-ol dehydrogenase | True | 0 | 0 | 0 | 1 | (+)-thujan-3-ol + NAD(P)+ = (+)-thujan-3-one + NAD(P)H + H+ | (+)-thujan-3-ol:NAD(P)+ oxidoreductase | None | d-3-thujanol dehydrogenase; TDH | |
| 1.1.1.324 | 8-hydroxygeraniol dehydrogenase | False | 1 | 10 | 1 | 3 | (6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction);;(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+;;(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+ ;;(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+ ;;(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ | (6E)-8-hydroxygeraniol:NADP+ oxidoreductase | None | 8-hydroxygeraniol oxidoreductase; CYP76B10; G10H; CrG10H; SmG10H; acyclic monoterpene primary alcohol:NADP+ oxidoreductase | |
| 1.1.1.325 | sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) | False | 1 | 88 | 0 | 2 | (1) L-threo-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+;;(2) L-threo-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ | L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase | None | None | |
| 1.1.1.326 | zerumbone synthase | False | 1 | 1 | 0 | 1 | 10-hydroxy-alpha-humulene + NAD+ = zerumbone + NADH + H+ | 10-hydroxy-alpha-humulene:NAD+ oxidoreductase | None | ZSD1 | |
| 1.3.8.3 | (R)-benzylsuccinyl-CoA dehydrogenase | False | 1 | 688 | 0 | 6 | (R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein | (R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase | None | BbsG; (R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase | |
| 1.3.8.4 | isovaleryl-CoA dehydrogenase | False | 9 | 12053 | 1 | 14 | isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein | 3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase | None | isovaleryl-coenzyme A dehydrogenase; isovaleroyl-coenzyme A dehydrogenase; 3-methylbutanoyl-CoA:(acceptor) oxidoreductase | |
| 1.3.99.32 | glutaryl-CoA dehydrogenase (acceptor) | False | 1 | 190 | 0 | 1 | glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor | glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating) | None | GDHDes; nondecarboxylating glutaryl-coenzyme A dehydrogenase; nondecarboxylating glutaconyl-coenzyme A-forming GDH; glutaryl-CoA dehydrogenase (non-decarboxylating) | |
| 1.14.13.153 | (+)-sabinene 3-hydroxylase | True | 0 | 0 | 0 | 1 | (+)-sabinene + NADPH + H+ + O2 = (+)-cis-sabinol + NADP+ + H2O | (+)-sabinene,NADPH:oxygen oxidoreductase (3-hydroxylating) | None | None | |
| 1.14.13.154 | erythromycin 12-hydroxylase | False | 1 | 42 | 1 | 1 | erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O | erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating) | None | EryK | |
| 1.14.99.46 | pyrimidine oxygenase | False | 66 | 1748 | 8 | 1 | (1) uracil + FMNH2 + O2 + NADH = (Z)-3-ureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction);;(1a) FMNH2 + O2 = FMN-N5-peroxide;;(1b) uracil + FMN-N5-peroxide = (Z)-3-ureidoacrylate + FMN-N5-oxide;;(1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous);;(2) thymine + FMNH2 + O2 + NADH = (Z)-2-methylureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction);;(2a) FMNH2 + O2 = FMN-N5-peroxide;;(2b) thymine + FMN-N5-peroxide = (Z)-2-methylureidoacrylate + FMN-N5-oxide;;(2c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous) | uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening) | None | rutA (gene name) | |
| 1.17.2.2 | lupanine 17-hydroxylase (cytochrome c) | False | 1 | 2 | 0 | 1 | lupanine + 2 ferricytochrome c + H2O = 17-hydroxylupanine + 2 ferrocytochrome c + 2 H+ | lupanine:cytochrome c-oxidoreductase (17-hydroxylating) | None | lupanine dehydrogenase (cytochrome c) | |
| 2.1.1.243 | 5-guanidino-2-oxopentanoate (3R)-methyltransferase | False | 2 | 19 | 1 | 1 | S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + (3R)-5-guanidino-3-methyl-2-oxopentanoate | S-adenosyl-L-methionine:5-guanidino-2-oxopentanoate (3R)-methyltransferase | None | mrsA (gene name); argN (gene name); 2-ketoarginine methyltransferase; S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase | |
| 2.1.1.244 | protein N-terminal methyltransferase | False | 18 | 4091 | 19 | 7 | (1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction);;(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein];;(1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein];;(1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein];;(2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction);;(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein];;(2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] | S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] methyltransferase | None | NMT1 (gene name); METTL11A (gene name) | |
| 2.1.1.245 | 5-methyltetrahydrosarcinapterin---corrinoid/iron-sulfur protein Co-methyltransferase | False | 9 | 657 | 0 | 4 | a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin | 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase | None | cdhD (gene name); cdhE (gene name) | |
| 2.1.1.246 | [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase | False | 2 | 62 | 0 | 3 | a [methyl-Co(III) methanol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methanol-specific corrinoid protein] | methylated methanol-specific corrinoid protein:CoM methyltransferase | None | methyltransferase 2 (ambiguous); mtaA (gene name) | |
| 2.1.1.247 | [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase | False | 3 | 37 | 2 | 3 | a [methyl-Co(III) methylamine-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methylamine-specific corrinoid protein] | methylated monomethylamine-specific corrinoid protein:CoM methyltransferase | None | methyltransferase 2 (ambiguous); MT2 (ambiguous); MT2-A; mtbA (gene name); [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase | |
| 2.1.1.248 | methylamine---corrinoid protein Co-methyltransferase | False | 8 | 425 | 0 | 2 | methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + NH3 | monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase | None | mtmB (gene name); monomethylamine methyltransferase | |
| 2.1.1.249 | dimethylamine---corrinoid protein Co-methyltransferase | False | 11 | 277 | 0 | 2 | dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] = a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine | dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase | None | mtbB (gene name); dimethylamine methyltransferase | |
| 2.1.1.250 | trimethylamine---corrinoid protein Co-methyltransferase | False | 10 | 221 | 3 | 5 | trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] = a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine | trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase | None | mttB (gene name); trimethylamine methyltransferase | |
| 2.1.1.251 | methylated-thiol---coenzyme M methyltransferase | False | 2 | 18 | 0 | 1 | methanethiol + CoM = methyl-CoM + hydrogen sulfide (overall reaction);; (1a) methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein] = a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide;;(1b) a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein] | methylated-thiol:CoM methyltransferase | None | mtsA (gene name) | |
| 2.1.1.252 | tetramethylammonium---corrinoid protein Co-methyltransferase | True | 0 | 0 | 0 | 1 | tetramethylammonium + a [Co(I) tetramethylammonium-specific corrinoid protein] = a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine | tetramethylammonium:5-hydroxybenzimidazolylcobamide Co-methyltransferase | None | mtqB (gene name); tetramethylammonium methyltransferase | |
| 2.1.1.253 | [methyl-Co(III) tetramethylammonium-specific corrinoid protein]---coenzyme M methyltransferase | True | 0 | 0 | 0 | 1 | a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) tetramethylammonium-specific corrinoid protein] | methylated tetramethylammonium-specific corrinoid protein:CoM methyltransferase | None | methyltransferase 2 (ambiguous); mtqA (gene name) | |
| 2.1.1.254 | erythromycin 3''-O-methyltransferase | False | 1 | 117 | 0 | 1 | (1) S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A;; (2) S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B | S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase | None | EryG | |
| 2.1.1.255 | geranyl diphosphate 2-C-methyltransferase | False | 4 | 82 | 0 | 10 | S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate | S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase | None | SCO7701; GPP methyltransferase; GPPMT; 2-methyl-GPP synthase; MGPPS; geranyl pyrophosphate methyltransferase | |
| 2.4.1.279 | nigerose phosphorylase | False | 1 | 16 | 0 | 1 | 3-O-alpha-D-glucopyranosyl-D-glucopyranose + phosphate = D-glucose + beta-D-glucose 1-phosphate | 3-O-alpha-D-glucopyranosyl-D-glucopyranose:phosphate beta-D-glucosyltransferase | None | cphy1874 (gene name) | |
| 2.4.1.280 | N,N'-diacetylchitobiose phosphorylase | False | 2 | 279 | 0 | 2 | N,N'-diacetylchitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate | N,N'-diacetylchitobiose:phosphate N-acetyl-D-glucosaminyltransferase | None | chbP (gene name) | |
| 2.4.1.281 | 4-O-beta-D-mannosyl-D-glucose phosphorylase | False | 2 | 1815 | 6 | 3 | 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate | 4-O-beta-D-mannopyranosyl-D-glucopyranose:phosphate alpha-D-mannosyltransferase | None | mannosylglucose phosphorylase | |
| 2.4.99.16 | starch synthase (maltosyl-transferring) | False | 22 | 8595 | 20 | 5 | alpha-maltose 1-phosphate + [(1->4)-alpha-D-glucosyl]n = phosphate + [(1->4)-alpha-D-glucosyl]n+2 | alpha-maltose 1-phosphate:(1->4)-alpha-D-glucan 4-alpha-D-maltosyltransferase | None | alpha1,4-glucan:maltose-1-P maltosyltransferase; GMPMT | |
| 2.7.1.173 | nicotinate riboside kinase | False | 8 | 5 | 1 | 3 | ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide | ATP:beta-D-ribosylnicotinate 5-phosphotransferase | None | ribosylnicotinic acid kinase; nicotinic acid riboside kinase; NRK1 (ambiguous) | |
| 2.7.1.174 | diacylglycerol kinase (CTP) | False | 3 | 32 | 0 | 1 | CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate | CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase | None | DAG kinase; CTP-dependent diacylglycerol kinase; diglyceride kinase (ambiguous); DGK1 (gene name); diacylglycerol kinase (CTP dependent) | |
| 2.7.1.175 | maltokinase | False | 20 | 6694 | 5 | 6 | ATP + maltose = ADP + alpha-maltose 1-phosphate | ATP:alpha-maltose 1-phosphotransferase | None | None | |
| 2.7.1.176 | UDP-N-acetylglucosamine kinase | False | 5 | 1260 | 0 | 5 | ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate | ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase | None | UNAG kinase; zeta toxin; toxin PezT; ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase | |
| 3.1.3.87 | 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase | False | 28 | 1074 | 0 | 2 | 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-en-1-yl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate | 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-en-1-yl phosphate phosphohydrolase | None | HK-MTPenyl-1-P phosphatase; MtnX; YkrX; 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate phosphohydrolase; 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate phosphohydrolase | |
| 3.1.7.11 | geranyl diphosphate diphosphatase | False | 11 | 16 | 0 | 10 | geranyl diphosphate + H2O = geraniol + diphosphate | geranyl-diphosphate diphosphohydrolase | None | geraniol synthase; geranyl pyrophosphate pyrophosphatase; GES; CtGES | |
| 3.5.1.110 | ureidoacrylate amidohydrolase | False | 65 | 1737 | 5 | 1 | (1) (Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + CO2 + NH3 (overall reaction);;(1a) (Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate;;(1b) carbamate = CO2 + NH3 (spontaneous);;(2) (Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + CO2 + NH3 (overall reaction);;(2a) (Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate;;(2b) carbamate = CO2 + NH3 (spontaneous) | (Z)-3-ureidoacrylate amidohydrolase | None | peroxyureidoacrylate/ureidoacrylate amidohydrolase; rutB (gene name); (Z)-3-ureidoacrylate peracid amidohydrolase | |
| 3.5.1.135 | N4-acetylcytidine amidohydrolase | False | 80 | 1403 | 0 | 1 | N4-acetylcytidine + H2O = cytidine + acetate | N4-acetylcytidine amidohydrolase | None | yqfB (gene name) | |
| 4.1.1.94 | ethylmalonyl-CoA decarboxylase | False | 9 | 1388 | 0 | 3 | (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2 | (S)-ethylmalonyl-CoA carboxy-lyase (butanoyl-CoA-forming) | None | None | |
| 4.1.2.50 | 6-carboxytetrahydropterin synthase | False | 21 | 18395 | 6 | 2 | 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate | 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming) | None | CPH4 synthase; queD (gene name); ToyB; ykvK (gene name) | |
| 4.2.1.132 | 2-hydroxyhexa-2,4-dienoate hydratase | False | 1 | 272 | 0 | 1 | 4-hydroxy-2-oxohexanoate = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O | 4-hydroxy-2-oxohexanoate hydro-lyase [(2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming] | None | tesE (gene name); hsaE (gene name) | |
| 4.2.3.105 | tricyclene synthase | False | 8 | 6 | 0 | 2 | geranyl diphosphate = tricyclene + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing; tricyclene-forming) | None | TPS3 | |
| 4.2.3.106 | (E)-beta-ocimene synthase | False | 20 | 20 | 0 | 10 | geranyl diphosphate = (E)-beta-ocimene + diphosphate | geranyl-diphosphate diphosphate-lyase [(E)-beta-ocimene-forming] | None | beta-ocimene synthase; AtTPS03; ama0a23; LjEbetaOS; MtEBOS | |
| 4.2.3.107 | (+)-car-3-ene synthase | False | 9 | 0 | 0 | 6 | geranyl diphosphate = (+)-car-3-ene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-car-3-ene-forming] | None | 3-carene cyclase; 3-carene synthase; 3CAR; (+)-3-carene synthase | |
| 4.2.3.108 | 1,8-cineole synthase | False | 12 | 3 | 0 | 15 | geranyl diphosphate + H2O = 1,8-cineole + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, 1,8-cineole-forming) | None | 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase | |
| 4.2.3.109 | (-)-sabinene synthase | False | 1 | 0 | 0 | 4 | geranyl diphosphate = (-)-sabinene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-sabinene-forming] | None | None | |
| 4.2.3.110 | (+)-sabinene synthase | False | 5 | 1 | 0 | 10 | geranyl diphosphate = (+)-sabinene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-sabinene-forming] | None | SS | |
| 4.2.3.111 | (-)-alpha-terpineol synthase | False | 10 | 18 | 0 | 5 | geranyl diphosphate + H2O = (-)-alpha-terpineol + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-terpineol-forming] | None | None | |
| 4.2.3.112 | (+)-alpha-terpineol synthase | False | 4 | 0 | 0 | 2 | geranyl diphosphate + H2O = (+)-alpha-terpineol + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-alpha-terpineol-forming] | None | None | |
| 4.2.3.113 | terpinolene synthase | False | 18 | 2 | 0 | 10 | geranyl diphosphate = terpinolene + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, terpinolene-forming) | None | ag9; PmeTPS2; LaLIMS_RR | |
| 4.2.3.114 | gamma-terpinene synthase | False | 10 | 7 | 0 | 9 | geranyl diphosphate = gamma-terpinene + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, gamma-terpinene-forming) | None | OvTPS2; ClcTS | |
| 4.2.3.115 | alpha-terpinene synthase | False | 4 | 0 | 0 | 2 | geranyl diphosphate = alpha-terpinene + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, alpha-terpinene-forming) | None | None | |
| 4.2.3.116 | (+)-camphene synthase | False | 1 | 0 | 0 | 3 | geranyl diphosphate = (+)-camphene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-camphene-forming] | None | None | |
| 4.2.3.117 | (-)-camphene synthase | False | 3 | 0 | 0 | 5 | geranyl diphosphate = (-)-camphene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-camphene-forming] | None | CS | |
| 4.2.3.118 | 2-methylisoborneol synthase | False | 5 | 5 | 2 | 9 | (E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate | (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming) | None | sco7700; 2-MIB cyclase; MIB synthase; MIBS | |
| 4.2.3.119 | (-)-alpha-pinene synthase | False | 15 | 13 | 0 | 11 | geranyl diphosphate = (-)-alpha-pinene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-pinene-forming] | None | (-)-alpha-pinene/(-)-camphene synthase; (-)-alpha-pinene cyclase | |
| 4.2.3.120 | (-)-beta-pinene synthase | False | 13 | 0 | 0 | 11 | geranyl diphosphate = (-)-beta-pinene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-beta-pinene-forming] | None | beta-geraniolene synthase; (-)-(1S,5S)-pinene synthase; geranyldiphosphate diphosphate lyase (pinene forming) | |
| 4.2.3.121 | (+)-alpha-pinene synthase | False | 6 | 1 | 0 | 9 | geranyl diphosphate = (+)-alpha-pinene + diphosphate | geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-alpha-pinene-forming] | None | (+)-alpha-pinene cyclase; cyclase I | |
| 4.2.3.122 | (+)-beta-pinene synthase | True | 0 | 0 | 0 | 3 | geranyl diphosphate = (+)-beta-pinene + diphosphate | geranyl-diphosphate diphosphate-lyase [(+)-beta-pinene-forming] | None | (+)-pinene cyclase; cyclase III | |
| 4.2.3.123 | beta-sesquiphellandrene synthase | False | 3 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-sesquiphellandrene-forming) | None | Tps1; Os08g07100 (gene name) | |
| 5.3.2.5 | 2,3-diketo-5-methylthiopentyl-1-phosphate enolase | False | 27 | 1023 | 0 | 7 | 5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate | 5-(methylsulfanyl)-2,3-dioxopentyl phosphate keto---enol-isomerase | None | DK-MTP-1-P enolase; MtnW; YkrW; RuBisCO-like protein; RLP; 2,3-diketo-5-methylthiopentyl-1-phosphate keto---enol-isomerase | |
| 5.3.99.10 | thiazole tautomerase | False | 1 | 45 | 0 | 1 | 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate | 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase | None | tenI (gene name) | |
| 6.3.4.20 | 7-cyano-7-deazaguanine synthase | False | 520 | 25771 | 0 | 4 | 7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O | 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming) | None | preQ0 synthase; 7-cyano-7-carbaguanine synthase; queC (gene name) | |
| 1.1.1.327 | 5-exo-hydroxycamphor dehydrogenase | False | 1 | 41 | 0 | 1 | 5-exo-hydroxycamphor + NAD+ = bornane-2,5-dione + NADH + H+ | 5-exo-hydroxycamphor:NAD+ oxidoreductase | None | F-dehydrogenase; FdeH | |
| 1.3.1.92 | artemisinic aldehyde Delta11(13)-reductase | False | 1 | 0 | 4 | 1 | (11R)-dihydroartemisinic aldehyde + NADP+ = artemisinic aldehyde + NADPH + H+ | artemisinic aldehyde:NADP+ oxidoreductase | None | Dbr2 | |
| 1.3.8.5 | short-chain 2-methylacyl-CoA dehydrogenase | False | 10 | 4176 | 0 | 4 | 2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+ | short-chain 2-methylacyl-CoA:electron-transfer flavoprotein 2-oxidoreductase | None | ACADSB (gene name); 2-methylacyl-CoA dehydrogenase; branched-chain acyl-CoA dehydrogenase (ambiguous); 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutanoyl-CoA:(acceptor) oxidoreductase; 2-methyl-branched-chain-acyl-CoA:electron-transfer flavoprotein 2-oxidoreductase; 2-methyl-branched-chain-enoyl-CoA reductase | |
| 1.3.8.6 | glutaryl-CoA dehydrogenase (ETF) | False | 7 | 15707 | 0 | 13 | glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein (overall reaction);;(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein;;(1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO2 | glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating) | None | glutaryl coenzyme A dehydrogenase; glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating); glutaryl-CoA dehydrogenase | |
| 1.3.8.7 | medium-chain acyl-CoA dehydrogenase | False | 18 | 13544 | 2 | 16 | a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein | medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | None | fatty acyl coenzyme A dehydrogenase (ambiguous); acyl coenzyme A dehydrogenase (ambiguous); acyl dehydrogenase (ambiguous); fatty-acyl-CoA dehydrogenase (ambiguous); acyl CoA dehydrogenase (ambiguous); general acyl CoA dehydrogenase (ambiguous); medium-chain acyl-coenzyme A dehydrogenase; acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous); ACADM (gene name). | |
| 1.3.8.8 | long-chain acyl-CoA dehydrogenase | False | 12 | 10024 | 3 | 10 | a long-chain acyl-CoA + electron-transfer flavoprotein = a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein | long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | None | palmitoyl-CoA dehydrogenase; palmitoyl-coenzyme A dehydrogenase; long-chain acyl-coenzyme A dehydrogenase; long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase; ACADL (gene name). | |
| 1.3.8.9 | very-long-chain acyl-CoA dehydrogenase | False | 5 | 1603 | 4 | 3 | a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein | very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | None | ACADVL (gene name). | |
| 1.4.1.23 | valine dehydrogenase (NAD+) | False | 5 | 1132 | 0 | 5 | L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ | L-valine:NAD+ oxidoreductase (deaminating) | None | None | |
| 1.13.11.63 | beta-carotene 15,15'-dioxygenase | False | 9 | 1866 | 0 | 19 | beta-carotene + O2 = 2 all-trans-retinal | beta-carotene:oxygen 15,15'-dioxygenase (bond-cleaving) | None | blh (gene name); BCO1 (gene name); BCDO (gene name); carotene dioxygenase; carotene 15,15'-dioxygenase; BCMO1 (misleading); beta-carotene 15,15'-monooxygenase (incorrect) | |
| 1.14.13.155 | alpha-pinene monooxygenase | True | 0 | 0 | 0 | 2 | (-)-alpha-pinene + NADH + H+ + O2 = alpha-pinene oxide + NAD+ + H2O | (-)-alpha-pinene,NADH:oxygen oxidoreductase | None | None | |
| 1.14.13.160 | (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase | False | 1 | 12 | 0 | 1 | [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + O2 + NADPH + H+ = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + NADP+ + H2O | [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA,NADPH:oxygen oxidoreductase (1,5-lactonizing) | None | 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase; 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase; OTEMO | |
| 1.14.13.161 | (+)-camphor 6-exo-hydroxylase | True | 0 | 0 | 0 | 2 | (+)-camphor + NADPH + H+ + O2 = (+)-6-exo-hydroxycamphor + NADP+ + H2O | (+)-camphor,NADPH:oxygen oxidoreductase (6-exo-hydroxylating) | None | (+)-camphor 6-hydroxylase | |
| 1.14.15.9 | spheroidene monooxygenase | False | 1 | 55 | 0 | 4 | (1) spheroidene + 4 reduced ferredoxin [iron-sulfur] cluster + 2 O2 + 4 H+ = spheroiden-2-one + 4 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O (overall reaction);;(1a) spheroidene + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2-hydroxyspheroidene + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) 2-hydroxyspheroidene + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2,2-dihydroxyspheroidene + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1c) 2,2-dihydroxyspheroidene = spheroiden-2-one + H2O (spontaneous);;(2) spirilloxanthin + 4 reduced ferredoxin [iron-sulfur] cluster + 2 O2 + 4 H+ = 2-oxospirilloxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O (overall reaction);;(2a) spirilloxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2-hydroxyspirilloxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(2b) 2-hydroxyspirilloxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2,2-dihydroxyspirilloxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(2c) 2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O (spontaneous);; (3) 2-oxospirilloxanthin + 4 reduced ferredoxin [iron-sulfur] cluster + 2 O2 + 4 H+ = 2,2'-dioxospirilloxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O (overall reaction);;(3a) 2-oxospirilloxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2'-hydroxy-2-oxospirilloxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(3b) 2'-hydroxy-2-oxospirilloxanthin + reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 2',2'-dihydroxy-2-oxospirilloxanthin + oxidized ferredoxin [iron-sulfur] cluster + H2O;;(3c) 2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O (spontaneous);; | spheroidene,reduced-ferredoxin:oxygen oxidoreductase (spheroiden-2-one-forming) | None | CrtA; acyclic carotenoid 2-ketolase; spirilloxanthin monooxygenase; 2-oxo-spirilloxanthin monooxygenase | |
| 1.14.15.10 | (+)-camphor 6-endo-hydroxylase | True | 0 | 0 | 0 | 1 | (+)-camphor + reduced putidaredoxin + O2 = (+)-6-endo-hydroxycamphor + oxidized putidaredoxin + H2O | (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (6-endo-hydroxylating) | None | P450camr | |
| 1.18.1.5 | putidaredoxin---NAD+ reductase | False | 1 | 148 | 0 | 1 | reduced putidaredoxin + NAD+ = oxidized putidaredoxin + NADH + H+ | putidaredoxin:NAD+ oxidoreductase | None | putidaredoxin reductase; camA (gene name) | |
| 2.1.1.256 | tRNA (guanine6-N2)-methyltransferase | False | 7 | 21 | 0 | 4 | S-adenosyl-L-methionine + guanine6 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA | S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase | None | methyltransferase Trm14; m2G6 methyltransferase | |
| 2.1.1.257 | tRNA (pseudouridine54-N1)-methyltransferase | False | 30 | 1529 | 0 | 4 | S-adenosyl-L-methionine + pseudouridine54 in tRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA | S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase | None | TrmY; m1Psi methyltransferase | |
| 2.2.1.10 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase | False | 12 | 2378 | 0 | 1 | L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate | L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase | None | ADH synthase; ADHS; MJ0400 (gene name) | |
| 2.2.1.11 | 6-deoxy-5-ketofructose 1-phosphate synthase | False | 1 | 9 | 0 | 3 | (1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate;;(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate | 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase | None | DKFP synthase | |
| 2.3.1.198 | glycerol-3-phosphate 2-O-acyltransferase | False | 2 | 13 | 0 | 5 | an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate | acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase | None | sn-2-glycerol-3-phosphate O-acyltransferase; glycerol-3-phosphate O-acyltransferase (ambiguous) | |
| 3.7.1.18 | 6-oxocamphor hydrolase | False | 1 | 44 | 0 | 2 | bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate | bornane-2,6-dione hydrolase | None | OCH; camK (gene name) | |
| 4.2.1.133 | copal-8-ol diphosphate hydratase | False | 5 | 9 | 0 | 6 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O | geranylgeranyl-diphosphate hydro-lyase [(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate-forming] | None | CcCLS | |
| 4.2.3.124 | 2-deoxy-scyllo-inosose synthase | False | 8 | 12 | 0 | 7 | D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate | D-glucose-6-phosphate phosphate-lyase (2-deoxy-L-scyllo-inosose-forming) | None | btrC (gene name); neoC (gene name); kanC (gene name) | |
| 4.2.3.125 | alpha-muurolene synthase | False | 10 | 1 | 0 | 2 | (2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-muurolene-forming) | None | Cop3 | |
| 4.2.3.126 | gamma-muurolene synthase | False | 10 | 5 | 0 | 2 | (2E,6E)-farnesyl diphosphate = gamma-muurolene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, gamma-muurolene-forming) | None | Cop3 | |
| 4.2.3.127 | beta-copaene synthase | False | 8 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-copaene-forming) | None | cop4 | |
| 4.2.3.128 | beta-cubebene synthase | False | 5 | 0 | 0 | 5 | (2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-cubebene-forming) | None | cop4; Mg25 | |
| 4.2.3.129 | (+)-sativene synthase | False | 2 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-sativene-forming) | None | cop4 | |
| 4.2.3.130 | tetraprenyl-beta-curcumene synthase | False | 1 | 117 | 0 | 7 | all-trans-heptaprenyl diphosphate = tetraprenyl-beta-curcumene + diphosphate | all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-beta-curcumene-forming) | None | ytpB (gene name) | |
| 4.3.99.3 | 7-carboxy-7-deazaguanine synthase | False | 40 | 25289 | 8 | 3 | 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3 | 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase | None | 7-carboxy-7-carbaguanine synthase; queE (gene name) | |
| 6.2.1.38 | (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase | True | 0 | 0 | 0 | 1 | [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate + ATP + CoA = AMP + diphosphate + [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA | [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate:CoA ligase (AMP-forming) | None | 2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase | |
| 1.1.1.328 | nicotine blue oxidoreductase | False | 1 | 303 | 0 | 1 | 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(P)+ = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-[3,3'-bipyridinylidene]-6,6'-dione + NAD(P)H + H+ | 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP+ 11-oxidoreductase | None | nboR (gene name) | |
| 1.1.1.329 | 2-deoxy-scyllo-inosamine dehydrogenase | False | 7 | 2968 | 0 | 2 | 2-deoxy-scyllo-inosamine + NAD(P)+ = 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+ | 2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase | None | neoA (gene name); kanK (gene name, ambiguous); kanE (gene name, ambiguous) | |
| 1.1.1.330 | very-long-chain 3-oxoacyl-CoA reductase | False | 52 | 2340 | 0 | 6 | a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+ | (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase | None | very-long-chain 3-ketoacyl-CoA reductase; very-long-chain beta-ketoacyl-CoA reductase; KCR (gene name); IFA38 (gene name) | |
| 1.1.1.331 | secoisolariciresinol dehydrogenase | False | 3 | 29 | 0 | 10 | (-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ | (-)-secoisolariciresinol:NAD+ oxidoreductase | None | None | |
| 1.1.1.332 | chanoclavine-I dehydrogenase | False | 8 | 0 | 0 | 4 | chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+ | chanoclavine-I:NAD+ oxidoreductase | None | easD (gene name); fgaDH (gene name) | |
| 1.1.1.333 | decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase | False | 4 | 815 | 0 | 2 | trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+ | trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase | None | decaprenylphospho-beta-D-ribofuranose 2'-epimerase; Rv3791; DprE2 | |
| 1.1.1.334 | methylecgonone reductase | False | 1 | 17 | 0 | 1 | ecgonine methyl ester + NADP+ = ecgonone methyl ester + NADPH + H+ | ecgonine methyl ester:NADP+ oxidoreductase | None | MecgoR (gene name) | |
| 1.1.3.43 | paromamine 6'-oxidase | False | 1 | 35 | 0 | 2 | paromamine + O2 = 6'-dehydroparomamine + H2O2 | paromamine:oxygen 6'-oxidoreductase | None | btrQ (gene name); neoG (gene name); kanI (gene name); tacB (gene name); neoQ (obsolete gene name) | |
| 1.1.3.44 | 6'''-hydroxyneomycin C oxidase | False | 1 | 6 | 0 | 2 | 6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2 | 6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase | None | neoG (gene name); neoQ (obsolete gene name) | |
| 1.1.98.3 | decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | False | 3 | 199 | 9 | 2 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase | None | decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase; Rv3790; DprE1; decaprenylphospho-beta-D-ribofuranose 2-oxidase | |
| 1.1.99.38 | 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent) | False | 1 | 50 | 0 | 1 | 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine | 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase | None | btrN (gene name); 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) | |
| 1.2.1.83 | 3-succinoylsemialdehyde-pyridine dehydrogenase | False | 1 | 473 | 0 | 1 | 4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ | 4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase | None | None | |
| 1.2.1.84 | alcohol-forming fatty acyl-CoA reductase | False | 21 | 13122 | 1 | 18 | a long-chain acyl-CoA + 2 NADPH + 2 H+ = a long-chain alcohol + 2 NADP+ + CoA | NADPH:long-chain acyl-CoA reductase | None | FAR (gene name); long-chain acyl-CoA:NADPH reductase | |
| 1.3.1.93 | very-long-chain enoyl-CoA reductase | False | 8 | 1457 | 0 | 5 | a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+ | very-long-chain acyl-CoA:NADP+ oxidoreductase | None | TSC13 (gene name); CER10 (gene name) | |
| 1.3.1.94 | polyprenol reductase | False | 18 | 3497 | 0 | 4 | ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ | ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase | None | SRD5A3 (gene name); DFG10 (gene name) | |
| 1.5.3.19 | 4-methylaminobutanoate oxidase (formaldehyde-forming) | False | 1 | 872 | 0 | 1 | 4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 | 4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming) | None | mabO (gene name) | |
| 1.5.3.20 | N-alkylglycine oxidase | True | 0 | 0 | 0 | 1 | N-alkylglycine + H2O + O2 = alkylamine + glyoxalate + H2O2 | N-alkylglycine:oxygen oxidoreductase (alkylamine-forming) | None | N-carboxymethylalkylamine:oxygen oxidoreductase (decarboxymethylating) | |
| 1.5.3.21 | 4-methylaminobutanoate oxidase (methylamine-forming) | False | 1 | 7 | 1 | 1 | 4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 | 4-methylaminobutanoate methylamidohydrolase | None | mao (gene name, ambiguous) | |
| 1.5.99.14 | 6-hydroxypseudooxynicotine dehydrogenase | False | 3 | 258 | 1 | 3 | 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O = 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor | 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating) | None | None | |
| 1.13.11.64 | 5-nitrosalicylate dioxygenase | False | 1 | 14 | 1 | 1 | 5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite (overall reaction);;(1a) 5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate;;(1b) 4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite (spontaneous) | 5-nitrosalicylate:oxygen 1,2-oxidoreductase (ring-opening) | None | naaB (gene name); 5-nitrosalicylate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.14.13.163 | 6-hydroxy-3-succinoylpyridine 3-monooxygenase | False | 2 | 78 | 1 | 4 | 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing) | None | 6-hydroxy-3-succinoylpyridine hydroxylase; hspA (gene name); hspB (gene name) | |
| 1.14.14.13 | 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase | False | 2 | 7 | 0 | 1 | 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O | 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein],FMNH2:oxygen oxidoreductase (2-hydroxylating) | None | btrO (gene name) | |
| 2.1.1.258 | 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase | False | 1 | 368 | 0 | 2 | a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase | None | acsE (gene name) | |
| 2.1.1.259 | [fructose-bisphosphate aldolase]-lysine N-methyltransferase | False | 2 | 9 | 0 | 2 | 3 S-adenosyl-L-methionine + [fructose-bisphosphate aldolase]-L-lysine = 3 S-adenosyl-L-homocysteine + [fructose-bisphosphate aldolase]-N6,N6,N6-trimethyl-L-lysine | S-adenosyl-L-methionine:[fructose-bisphosphate aldolase]-lysine N6-methyltransferase | None | rubisco methyltransferase; ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase; ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase; S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine 6-N-methyltransferase | |
| 2.3.1.199 | very-long-chain 3-oxoacyl-CoA synthase | False | 69 | 17151 | 1 | 13 | a very-long-chain acyl-CoA + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA | malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing) | None | very-long-chain 3-ketoacyl-CoA synthase; very-long-chain beta-ketoacyl-CoA synthase; condensing enzyme (ambiguous); CUT1 (gene name); CER6 (gene name); FAE1 (gene name); KCS (gene name); ELO (gene name) | |
| 2.3.1.200 | lipoyl amidotransferase | False | 4 | 109 | 0 | 2 | [glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine | [glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase | None | LipL (gene name, ambiguous) | |
| 2.3.1.201 | UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase | False | 1 | 325 | 0 | 3 | acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate | acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase | None | WbpD; WlbB | |
| 2.3.1.202 | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | False | 1 | 546 | 1 | 2 | acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose | acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | None | PseH | |
| 2.3.1.203 | UDP-N-acetylbacillosamine N-acetyltransferase | False | 2 | 221 | 2 | 3 | acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP-N,N'-diacetylbacillosamine | acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase | None | UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase; pglD (gene name) | |
| 2.3.2.19 | ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase | False | 1 | 0 | 0 | 1 | 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin = gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein | ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase | None | btrH (gene name) | |
| 2.4.1.282 | 3-O-alpha-D-glucosyl-L-rhamnose phosphorylase | False | 1 | 0 | 0 | 1 | 3-O-alpha-D-glucopyranosyl-L-rhamnopyranose + phosphate = L-rhamnopyranose + beta-D-glucose 1-phosphate | 3-O-alpha-D-glucopyranosyl-L-rhamnopyranose:phosphate beta-D-glucosyltransferase | None | cphy1019 (gene name) | |
| 2.4.1.283 | 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase | False | 3 | 65 | 0 | 3 | UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N-acetylparomamine | UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase | None | btrM (gene name); neoD (gene name); kanF (gene name) | |
| 2.4.1.284 | 2-deoxystreptamine glucosyltransferase | False | 1 | 247 | 0 | 1 | UDP-alpha-D-glucose + 2-deoxystreptamine = UDP + 2'-deamino-2'-hydroxyparomamine | UDP-alpha-D-glucose:2-deoxystreptamine 6-alpha-D-glucosyltransferase | None | kanF (gene name) | |
| 2.4.1.285 | UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase | False | 1 | 4 | 0 | 2 | UDP-N-acetyl-alpha-D-glucosamine + ribostamycin = UDP + 2'''-acetyl-6'''-hydroxyneomycin C | UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase | None | neoK (gene name) | |
| 2.4.1.286 | chalcone 4'-O-glucosyltransferase | False | 1 | 2 | 0 | 1 | (1) UDP-alpha-D-glucose + naringenin chalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside;;(2) UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = UDP + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside | UDP-alpha-D-glucose:2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucosyltransferase | None | 4'CGT | |
| 2.4.1.287 | rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase | False | 3 | 176 | 0 | 2 | 2 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 2 UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol (overall reaction);;(1a) UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;;(1b) UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol | UDP-alpha-D-galactofuranose:alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 4-beta/4-beta-galactofuranosyltransferase (configuration-inverting) | None | arabinogalactan galactofuranosyl transferase 1; GlfT1 | |
| 2.4.1.288 | galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase | False | 2 | 230 | 0 | 3 | 28 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 28 UDP + [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | UDP-alpha-D-galactofuranose:beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 4-beta/5-beta-D-galactofuranosyltransferase | None | GlfT2 | |
| 2.4.2.45 | decaprenyl-phosphate phosphoribosyltransferase | False | 4 | 2963 | 2 | 3 | trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate:diphosphate phospho-alpha-D-ribosyltransferase | None | 5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase; 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase; DPPR synthase; Rv3806 | |
| 2.4.2.46 | galactan 5-O-arabinofuranosyltransferase | False | 6 | 1062 | 1 | 3 | Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 5-O-position of the eighth, tenth and twelfth galactofuranose unit of the galactofuranan chain of [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | galactofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 5-O-alpha-D-arabinofuranosyltransferase | None | AftA; Rv3792 | |
| 2.4.2.47 | arabinofuranan 3-O-arabinosyltransferase | False | 6 | 162 | 0 | 3 | Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain | alpha-(1->5)-arabinofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 3-O-alpha-D-arabinofuranosyltransferase | None | AftC | |
| 2.4.99.17 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | False | 536 | 32983 | 0 | 3 | S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine34 in tRNA = L-methionine + adenine + epoxyqueuosine34 in tRNA | S-adenosyl-L-methionine:7-aminomethyl-7-deazaguanosine ribosyltransferase (ribosyl isomerizing; L-methionine, adenine releasing) | None | QueA enzyme; queuosine biosynthesis protein QueA | |
| 2.6.1.93 | neamine transaminase | False | 3 | 3 | 4 | 3 | neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate | neamine:2-oxoglutarate aminotransferase | None | glutamate---6'-dehydroparomamine aminotransferase; btrB (gene name); neoN (gene name); kacL (gene name) | |
| 2.6.1.94 | 2'-deamino-2'-hydroxyneamine transaminase | False | 1 | 7 | 0 | 1 | 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate | 2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase | None | kacL (gene name) | |
| 2.6.1.95 | neomycin C transaminase | False | 1 | 1 | 0 | 1 | neomycin C + 2-oxoglutarate = 6'''-deamino-6'''-oxoneomycin C + L-glutamate | 2-oxoglutarate:neomycin C aminotransferase | None | neoN (gene name) | |
| 2.7.1.177 | L-threonine kinase | False | 2 | 399 | 0 | 3 | ATP + L-threonine = ADP + O-phospho-L-threonine | ATP:L-threonine O3-phosphotransferase | None | PduX | |
| 2.7.4.26 | isopentenyl phosphate kinase | False | 5 | 3833 | 6 | 8 | ATP + 3-methylbut-3-en-1-yl phosphate = ADP + 3-methylbut-3-en-1-yl diphosphate | ATP:3-methylbut-3-en-1-yl-phosphate phosphotransferase | None | ATP:isopentenyl phosphate phosphotransferase | |
| 2.7.8.35 | UDP-N-acetylglucosamine---decaprenyl-phosphate N-acetylglucosaminephosphotransferase | False | 4 | 233 | 0 | 3 | UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | UDP-N-acetyl-alpha-D-glucosamine:trans,octacis-decaprenyl-phosphate N-acetylglucosaminephosphotransferase | None | GlcNAc-1-phosphate transferase; UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase; WecA; WecA transferase | |
| 3.1.1.91 | 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase | False | 1 | 1 | 0 | 1 | 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = maleylpyruvate | 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonohydrolase | None | naaC (gene name) | |
| 3.1.1.92 | 4-sulfomuconolactone hydrolase | False | 2 | 202 | 0 | 2 | 4-sulfomuconolactone + H2O = maleylacetate + sulfite | 4-sulfomuconolactone sulfohydrolase | None | None | |
| 3.1.1.93 | mycophenolic acid acyl-glucuronide esterase | False | 5 | 4634 | 1 | 1 | mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate | mycophenolic acid O-acyl-glucuronide-ester hydrolase | None | mycophenolic acid acyl-glucuronide deglucuronidase; AcMPAG deglucuronidase | |
| 3.1.3.88 | 5''-phosphoribostamycin phosphatase | False | 1 | 3 | 0 | 1 | 5''-phosphoribostamycin + H2O = ribostamycin + phosphate | 5''-phosphoribostamycin phosphohydrolase | None | btrP (gene name); neoI (gene name) | |
| 3.2.1.181 | galactan endo-beta-1,3-galactanase | False | 1 | 3 | 0 | 3 | The enzyme specifically hydrolyses beta-1,3-galactan and beta-1,3-galactooligosaccharides | arabinogalactan 3-beta-D-galactanohydrolase | None | endo-beta-1,3-galactanase | |
| 3.5.99.9 | 2-nitroimidazole nitrohydrolase | False | 1 | 4 | 0 | 1 | 2-nitroimidazole + H2O = imidazol-2-one + nitrite | 2-nitroimidazole nitrohydrolase | None | NnhA; 2NI nitrohydrolase; 2NI denitrase | |
| 3.7.1.19 | 2,6-dihydroxypseudooxynicotine hydrolase | False | 1 | 193 | 0 | 2 | 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate | 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase | None | None | |
| 4.1.1.95 | L-glutamyl-[BtrI acyl-carrier protein] decarboxylase | False | 1 | 139 | 1 | 1 | L-glutamyl-[BtrI acyl-carrier protein] = 4-amino butanoyl-[BtrI acyl-carrier protein] + CO2 | L-glutamyl-[BtrI acyl-carrier protein] carboxy-lyase | None | btrK (gene name) | |
| 4.1.1.96 | carboxynorspermidine decarboxylase | False | 6 | 7655 | 0 | 7 | (1) carboxynorspermidine = bis(3-aminopropyl)amine + CO2;;(2) carboxyspermidine = spermidine + CO2 | carboxynorspermidine carboxy-lyase (bis(3-aminopropyl)amine-forming) | None | carboxyspermidine decarboxylase; CANSDC; VC1623 (gene name) | |
| 4.2.3.131 | miltiradiene synthase | False | 6 | 1 | 0 | 5 | (+)-copalyl diphosphate = miltiradiene + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming) | None | SmMDS; SmiKSL; RoKSL | |
| 4.2.3.132 | neoabietadiene synthase | False | 6 | 0 | 0 | 2 | (+)-copalyl diphosphate = neoabietadiene + diphosphate | (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming) | None | TPS-LAS | |
| 4.2.3.133 | alpha-copaene synthase | False | 10 | 3 | 0 | 7 | (2E,6E)-farnesyl diphosphate = (-)-alpha-copaene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-copaene-forming) | None | None | |
| 4.3.2.6 | gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase | False | 1 | 41 | 0 | 1 | gamma-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline | gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxo-L-proline producing) | None | btrG (gene name); gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing) | |
| 5.3.2.6 | 2-hydroxymuconate tautomerase | False | 9 | 1376 | 11 | 11 | (2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate | (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto---enol isomerase | None | 4-oxalocrotonate tautomerase (misleading); 4-oxalocrotonate isomerase (misleading); cnbG (gene name); praC (gene name); xylH (gene name) | |
| 5.4.3.9 | glutamate 2,3-aminomutase | False | 1 | 181 | 0 | 2 | L-glutamate = 3-aminopentanedioate | L-glutamate 2,3-aminomutase | None | None | |
| 6.2.1.39 | [butirosin acyl-carrier protein]---L-glutamate ligase | False | 1 | 21 | 0 | 1 | (1) ATP + L-glutamate + BtrI acyl-carrier protein = ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein];;(2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] = ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] | [BtrI acyl-carrier protein]:L-glutamate ligase (ADP-forming) | None | [BtrI acyl-carrier protein]---L-glutamate ligase; BtrJ | |
| 6.3.2.38 | N2-citryl-N6-acetyl-N6-hydroxylysine synthase | False | 2 | 138 | 0 | 2 | 2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N6-acetyl-N2-citryl-N6-hydroxy-L-lysine | citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming) | None | Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase; iucA (gene name) | |
| 6.3.2.39 | aerobactin synthase | False | 2 | 175 | 0 | 2 | ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = AMP + diphosphate + aerobactin | N2-citryl-N6-acetyl-N6-hydroxy-L-lysine:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming) | None | iucC (gene name) | |
| 1.1.1.335 | UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase | False | 1 | 125 | 0 | 5 | UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD+ = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H+ | UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase | None | WlbA; WbpB | |
| 1.1.1.336 | UDP-N-acetyl-D-mannosamine dehydrogenase | False | 13 | 5789 | 0 | 7 | UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+ | UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase | None | UDP-ManNAc 6-dehydrogenase; wecC (gene name) | |
| 1.1.1.337 | L-2-hydroxycarboxylate dehydrogenase (NAD+) | False | 2 | 41 | 0 | 5 | a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ | (2S)-2-hydroxycarboxylate:NAD+ oxidoreductase | None | (R)-sulfolactate:NAD+ oxidoreductase; L-sulfolactate dehydrogenase; (R)-sulfolactate dehydrogenase; L-2-hydroxyacid dehydrogenase (NAD+); ComC | |
| 1.1.1.338 | (2R)-3-sulfolactate dehydrogenase (NADP+) | False | 1 | 295 | 0 | 1 | (2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+ | (2R)-3-sulfolactate:NADP+ oxidoreductase | None | (R)-sulfolactate:NADP+ oxidoreductase; L-sulfolactate dehydrogenase; (R)-sulfolactate dehydrogenase; ComC | |
| 1.1.1.339 | dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) | False | 1 | 85 | 0 | 1 | dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ | dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase | None | tll (gene name) | |
| 1.1.1.340 | 1-deoxy-11beta-hydroxypentalenate dehydrogenase | False | 3 | 174 | 0 | 1 | 1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ | 1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase | None | 1-deoxy-11beta-hydroxypentalenic acid dehydrogenase; ptlF (gene name); penF (gene name) | |
| 1.1.1.341 | CDP-abequose synthase | False | 3 | 34 | 0 | 2 | CDP-alpha-D-abequose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ | CDP-alpha-D-abequose:NADP+ 4-oxidoreductase | None | rfbJ (gene name) | |
| 1.1.1.342 | CDP-paratose synthase | False | 1 | 0 | 0 | 1 | CDP-alpha-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ | CDP-alpha-D-paratose:NADP+ 4-oxidoreductase | None | rfbS (gene name) | |
| 1.2.1.85 | 2-hydroxymuconate-6-semialdehyde dehydrogenase | False | 2 | 893 | 0 | 5 | 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ | 2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase | None | xylG (gene name); praB (gene name) | |
| 1.2.1.86 | geranial dehydrogenase | False | 1 | 173 | 0 | 3 | geranial + H2O + NAD+ = geranate + NADH + H+ | geranial:NAD+ oxidoreductase | None | GaDH; geoB (gene name) | |
| 1.3.1.95 | acrylyl-CoA reductase (NADH) | False | 1 | 2146 | 0 | 4 | propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ | propanoyl-CoA:NAD+ oxidoreductase | None | None | |
| 1.3.1.96 | Botryococcus squalene synthase | False | 1 | 0 | 0 | 1 | squalene + diphosphate + NADP+ = presqualene diphosphate + NADPH + H+ | squalene:NADP+ oxidoreductase | None | SSL-2 (gene name) | |
| 1.3.1.97 | botryococcene synthase | False | 1 | 1 | 0 | 1 | C30 botryococcene + NADP+ + diphosphate = presqualene diphosphate + NADPH + H+ | C30 botryococcene:NADP+ oxidoreductase | None | SSL-3 (gene name) | |
| 1.4.1.24 | 3-dehydroquinate synthase II | False | 31 | 1228 | 0 | 5 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating) | None | DHQ synthase II; MJ1249 (gene name); aroB' (gene name) | |
| 1.5.1.43 | carboxynorspermidine synthase | False | 2 | 361 | 0 | 6 | (1) carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+;;(2) carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+ | carboxynorspermidine:NADP+ oxidoreductase | None | carboxynorspermidine dehydrogenase; carboxyspermidine dehydrogenase; CASDH; CANSDH; VC1624 (gene name) | |
| 1.5.1.44 | festuclavine dehydrogenase | False | 3 | 1 | 0 | 3 | festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ | festuclavine:NAD+ oxidoreductase | None | FgaFS; festuclavine synthase | |
| 1.5.1.45 | FAD reductase [NAD(P)H] | False | 1 | 76 | 0 | 1 | FADH2 + NAD(P)+ = FAD + NAD(P)H + H+ | FADH2:NAD(P)+ oxidoreductase | None | GTNG_3158 (gene name) | |
| 1.7.2.6 | hydroxylamine dehydrogenase | False | 2 | 238 | 2 | 11 | hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+ | hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming) | None | HAO (ambiguous); hydroxylamine oxidoreductase (ambiguous); hydroxylamine oxidase (misleading) | |
| 1.13.11.65 | carotenoid isomerooxygenase | False | 2 | 0 | 0 | 5 | zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal | zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing) | None | ninaB (gene name) | |
| 1.13.11.66 | hydroquinone 1,2-dioxygenase | False | 1 | 28 | 0 | 8 | benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate | benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening) | None | hydroquinone dioxygenase; benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.13.11.67 | 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase | True | 0 | 0 | 0 | 3 | 8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + an uncharacterized product | 8'-apo-beta-carotenol:oxygen oxidoreductase (14',13'-cleaving) | None | 8'-apo-beta-carotenol:O2 oxidoreductase (14',13'-cleaving) | |
| 1.13.11.68 | 9-cis-beta-carotene 9',10'-cleaving dioxygenase | False | 2 | 2 | 0 | 8 | 9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone | 9-cis-beta-carotene:oxygen oxidoreductase (9',10'-cleaving) | None | CCD7 (gene name); MAX3 (gene name); NCED7 (gene name) | |
| 1.13.11.69 | carlactone synthase | False | 2 | 3 | 0 | 5 | 9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal | 9-cis-10'-apo-beta-carotenal:oxygen oxidoreductase (14,15-cleaving, carlactone-forming) | None | CCD8 (gene name); MAX4 (gene name); NCED8 (gene name) | |
| 1.13.11.70 | all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase | False | 2 | 4 | 0 | 8 | all-trans-10'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + (2E,4E,6E)-4-methylocta-2,4,6-trienedial | all-trans-10'-apo-beta-carotenal:oxygen oxidoreductase (13,14-cleaving) | None | CCD8 (gene name); MAX4 (gene name); NCED8 (gene name); all-trans-10'-apo-beta-carotenal:O2 oxidoreductase (13,14-cleaving) | |
| 1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase | False | 5 | 1697 | 0 | 10 | all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone | all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving) | None | BCO2 (gene name); beta-carotene 9',10'-monooxygenase (misleading); all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving) | |
| 1.13.11.72 | 2-hydroxyethylphosphonate dioxygenase | False | 1 | 4 | 1 | 1 | 2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate | 2-hydroxyethylphosphonate:oxygen 1,2-oxidoreductase (hydroxymethylphosphonate-forming) | None | HEPD; phpD (gene name); 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming) | |
| 1.13.11.73 | methylphosphonate synthase | False | 1 | 5 | 2 | 2 | 2-hydroxyethylphosphonate + O2 = methylphosphonate + hydrogen carbonate | 2-hydroxyethylphosphonate:oxygen 1,2-oxidoreductase (methylphosphonate-forming) | None | mpnS (gene name); 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (methylphosphonate-forming) | |
| 1.14.11.35 | 1-deoxypentalenic acid 11beta-hydroxylase | False | 3 | 85 | 0 | 1 | 1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + succinate + CO2 | 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase | None | ptlH (gene name); sav2991 (gene name); pntH (gene name) | |
| 1.14.11.36 | pentalenolactone F synthase | False | 3 | 12 | 0 | 2 | pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction);;(1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O;;(1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 | pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase | None | penD (gene name); pntD (gene name); ptlD (gene name) | |
| 1.14.13.166 | 4-nitrocatechol 4-monooxygenase | False | 2 | 52 | 0 | 5 | 4-nitrocatechol + NAD(P)H + H+ + O2 = 2-hydroxy-1,4-benzoquinone + nitrite + NAD(P)+ + H2O | 4-nitrocatechol,NAD(P)H:oxygen 4-oxidoreductase (4-hydroxylating, nitrite-forming) | None | None | |
| 1.14.13.167 | 4-nitrophenol 4-monooxygenase | False | 1 | 26 | 0 | 4 | 4-nitrophenol + NADPH + H+ + O2 = 1,4-benzoquinone + nitrite + NADP+ + H2O | 4-nitrophenol,NAD(P)H:oxygen 4-oxidoreductase (4-hydroxylating, nitrite-forming) | None | pnpA (gene name); pdcA (gene name) | |
| 1.14.13.168 | indole-3-pyruvate monooxygenase | False | 15 | 1751 | 0 | 1 | (indol-3-yl)pyruvate + NADPH + H+ + O2 = (indol-3-yl)acetate + NADP+ + H2O + CO2 | indole-3-pyruvate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | None | YUC2 (gene name); spi1 (gene name) | |
| 1.14.13.170 | pentalenolactone D synthase | False | 2 | 25 | 0 | 2 | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D-forming) | None | penE (gene name); pntE (gene name) | |
| 1.14.13.171 | neopentalenolactone D synthase | False | 1 | 36 | 0 | 3 | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = neopentalenolactone D + NADP+ + H2O | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D-forming) | None | ptlE (gene name) | |
| 1.14.15.11 | pentalenic acid synthase | False | 1 | 97 | 1 | 1 | 1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O | 1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase | None | CYP105D7; sav7469 (gene name); 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase | |
| 1.14.99.47 | (+)-larreatricin hydroxylase | False | 1 | 1 | 0 | 1 | (+)-larreatricin + reduced acceptor + O2 = (+)-3'-hydroxylarreatricin + acceptor + H2O | (+)-larreatricin:oxygen 3'-hydroxylase | None | None | |
| 1.18.1.6 | adrenodoxin-NADP+ reductase | False | 10 | 3804 | 1 | 4 | 2 reduced adrenodoxin + NADP+ + H+ = 2 oxidized adrenodoxin + NADPH | reduced adrenodoxin:NADP+ oxidoreductase | None | adrenodoxin reductase; nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase; AdR; NADPH:adrenal ferredoxin oxidoreductase; NADPH-adrenodoxin reductase | |
| 1.21.3.7 | tetrahydrocannabinolic acid synthase | False | 1 | 5 | 0 | 1 | cannabigerolate + O2 = Delta9-tetrahydrocannabinolate + H2O2 | cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming) | None | THCA synthase; Delta1-tetrahydrocannabinolic acid synthase | |
| 1.21.3.8 | cannabidiolic acid synthase | False | 1 | 4 | 0 | 1 | cannabigerolate + O2 = cannabidiolate + H2O2 | cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming) | None | CBDA synthase | |
| 2.1.1.260 | rRNA small subunit pseudouridine methyltransferase Nep1 | False | 1 | 97 | 22 | 5 | S-adenosyl-L-methionine + pseudouridine1191 in yeast 18S rRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine1191 in yeast 18S rRNA | S-adenosyl-L-methionine:18S rRNA (pseudouridine1191-N1)-methyltransferase | None | Nep1; nucleolar essential protein 1 | |
| 2.1.1.261 | 4-dimethylallyltryptophan N-methyltransferase | False | 10 | 450 | 0 | 1 | S-adenosyl-L-methionine + 4-prenyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-prenyl-L-abrine | S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase | None | fgaMT (gene name); easF (gene name) | |
| 2.1.1.262 | squalene methyltransferase | False | 2 | 0 | 0 | 1 | 2 S-adenosyl-L-methionine + squalene = 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (overall reaction);;(1a) S-adenosyl-L-methionine + squalene = S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene;;(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene = S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene | S-adenosyl-L-methionine:squalene C-methyltransferase | None | TMT-1; TMT-2 | |
| 2.1.1.263 | botryococcene C-methyltransferase | False | 1 | 0 | 0 | 1 | 2 S-adenosyl-L-methionine + C30 botryococcene = 2 S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene (overall reaction);;(1a) S-adenosyl-L-methionine + C30 botryococcene = S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene;;(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene = S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene;;(2a) S-adenosyl-L-methionine + C30 botryococcene = S-adenosyl-L-homocysteine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene;;(2b) S-adenosyl-L-methionine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene = S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene | S-adenosyl-L-methionine:botryococcene C-methyltransferase | None | TMT-3 | |
| 2.1.1.264 | 23S rRNA (guanine2069-N7)-methyltransferase | False | 166 | 6153 | 0 | 4 | S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase | None | rlmK (gene name); 23S rRNA m7G2069 methyltransferase | |
| 2.1.1.265 | tellurite methyltransferase | False | 1 | 791 | 0 | 1 | S-adenosyl-L-methionine + tellurite = S-adenosyl-L-homocysteine + methanetelluronate | S-adenosyl-L-methionine:tellurite methyltransferase | None | TehB | |
| 2.3.1.204 | octanoyl-[GcvH]:protein N-octanoyltransferase | False | 16 | 1360 | 0 | 2 | [glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine | [glycine cleavage system H]-N6-octanoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine octanoyltransferase | None | LipL; octanoyl-[GcvH]:E2 amidotransferase; ywfL (gene name) | |
| 2.3.1.205 | fumigaclavine B O-acetyltransferase | False | 2 | 0 | 0 | 1 | acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A | acetyl-CoA:fumigaclavine B O-acetyltransferase | None | FgaAT | |
| 2.3.1.206 | 3,5,7-trioxododecanoyl-CoA synthase | False | 1 | 0 | 2 | 1 | 3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming) | None | TKS (ambiguous); olivetol synthase (incorrect) | |
| 2.3.1.207 | beta-ketodecanoyl-[acyl-carrier-protein] synthase | False | 1 | 183 | 0 | 1 | octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 | octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming) | None | None | |
| 2.3.1.208 | 4-hydroxycoumarin synthase | False | 2 | 0 | 0 | 2 | malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2 | malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase | None | BIS2; BIS3 | |
| 2.3.1.209 | dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase | False | 1 | 34 | 0 | 3 | acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose | acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-glucose N-acetyltransferase | None | VioB | |
| 2.3.1.210 | dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase | False | 2 | 1588 | 0 | 1 | acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose | acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase | None | TDP-fucosamine acetyltransferase; WecD; RffC | |
| 2.4.1.289 | N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase | False | 2 | 1069 | 0 | 5 | dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase | None | WbbL | |
| 2.4.1.290 | N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase | False | 1 | 379 | 3 | 1 | UDP-N-acetyl-alpha-D-galactosamine + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol = UDP + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol | UDP-N-acetyl-alpha-D-galactosamine:N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol 3-alpha-N-acetyl-D-galactosaminyltransferase | None | PglA | |
| 2.4.1.291 | N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase | False | 1 | 528 | 0 | 1 | UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol = UDP + N-acetyl-D-galactosaminyl-alpha-(1->4)-N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol | UDP-N-acetyl-alpha-D-galactosamine:N-acetylgalactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol 3-alpha-N-acetyl-D-galactosaminyltransferase | None | PglJ | |
| 2.4.1.292 | GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase | False | 1 | 353 | 0 | 4 | 3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol = 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol | UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase | None | PglH | |
| 2.4.1.293 | GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase | False | 1 | 270 | 0 | 1 | UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-diphospho-tritrans,heptacis-undecaprenol = UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-diNAcBac-diphospho-tritrans,heptacis-undecaprenol | UDP-alpha-D-glucose:[GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-diphospho-tritrans,heptacis-undecaprenol 3-beta-D-glucosyltransferase | None | PglI | |
| 2.4.2.48 | tRNA-guanine15 transglycosylase | False | 35 | 2068 | 0 | 6 | guanine15 in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine15 in tRNA + guanine | tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase | None | tRNA transglycosylase (ambiguous); transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine15 transglycosidase; TGT (ambiguous); transfer ribonucleic acid guanine15 transglycosylase | |
| 2.4.99.18 | dolichyl-diphosphooligosaccharide---protein glycotransferase | False | 16 | 7885 | 33 | 78 | dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine | dolichyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligopolysaccharidotransferase | None | dolichyldiphosphooligosaccharide-protein glycosyltransferase; asparagine N-glycosyltransferase; dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase; dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase; oligomannosyltransferase; oligosaccharide transferase; dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase; dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase; STT3 | |
| 2.4.99.19 | undecaprenyl-diphosphooligosaccharide---protein glycotransferase | False | 3 | 69 | 2 | 4 | tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine = tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine | tritrans,heptacis-undecaprenyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase | None | PglB | |
| 2.5.1.100 | fumigaclavine A dimethylallyltransferase | False | 1 | 0 | 0 | 1 | fumigaclavine A + prenyl diphosphate = fumigaclavine C + diphosphate | prenyl-diphosphate:fumigaclavine A prenyltransferase | None | FgaPT1; dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase | |
| 2.5.1.101 | N,N'-diacetyllegionaminate synthase | False | 2 | 453 | 0 | 2 | 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate | phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase | None | neuB (gene name); legI (gene name) | |
| 2.5.1.102 | geranyl-pyrophosphate---olivetolic acid geranyltransferase | False | 1 | 0 | 0 | 1 | geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate | geranyl-diphosphate:olivetolate geranyltransferase | None | GOT (ambiguous) | |
| 2.5.1.103 | presqualene diphosphate synthase | False | 4 | 1715 | 0 | 2 | 2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate | (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate-forming) | None | SSL-1 (gene name); hpnD (gene name) | |
| 2.6.1.96 | 4-aminobutyrate---pyruvate transaminase | False | 11 | 126 | 0 | 6 | (1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine;;(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine | 4-aminobutanoate:pyruvate aminotransferase | None | aminobutyrate aminotransferase (ambiguous); gamma-aminobutyrate aminotransaminase (ambiguous); gamma-aminobutyrate transaminase (ambiguous); gamma-aminobutyric acid aminotransferase (ambiguous); gamma-aminobutyric acid pyruvate transaminase; gamma-aminobutyric acid transaminase (ambiguous); gamma-aminobutyric transaminase (ambiguous); 4-aminobutyrate aminotransferase (ambiguous); 4-aminobutyric acid aminotransferase (ambiguous); aminobutyrate transaminase (ambiguous); GABA aminotransferase (ambiguous); GABA transaminase (ambiguous); GABA transferase (ambiguous); POP2 (gene name) | |
| 2.6.1.97 | archaeosine synthase | False | 2 | 124 | 0 | 8 | L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA | L-glutamine:7-cyano-7-carbaguanine aminotransferase | None | ArcS; TgtA2; MJ1022 (gene name); glutamine:preQ0-tRNA amidinotransferase (incorrect) | |
| 2.6.1.98 | UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase | False | 1 | 460 | 0 | 3 | UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate | UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase | None | WbpE; WlbC | |
| 2.6.1.99 | L-tryptophan---pyruvate aminotransferase | False | 3 | 16 | 0 | 3 | L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine | L-tryptophan:pyruvate aminotransferase | None | TAA1 (gene name); vt2 (gene name) | |
| 2.7.4.27 | [pyruvate, phosphate dikinase]-phosphate phosphotransferase | False | 198 | 7999 | 0 | 3 | [pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate | [pyruvate, phosphate dikinase]-phosphate:phosphate phosphotransferase | None | PPDK regulatory protein (ambiguous); pyruvate, phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous); PDRP1 (gene name) | |
| 2.7.4.28 | [pyruvate, water dikinase]-phosphate phosphotransferase | False | 206 | 6871 | 0 | 1 | [pyruvate, water dikinase] phosphate + phosphate = [pyruvate, water dikinase] + diphosphate | [pyruvate, water dikinase]-phosphate:phosphate phosphotransferase | None | PSRP (ambiguous) | |
| 2.7.7.82 | CMP-N,N'-diacetyllegionaminic acid synthase | False | 2 | 316 | 0 | 2 | CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate | CTP:N,N'-diacetyllegionaminate cytidylyltransferase | None | CMP-N,N'-diacetyllegionaminic acid synthetase; neuA (gene name); legF (gene name) | |
| 2.7.7.83 | UDP-N-acetylgalactosamine diphosphorylase | False | 5 | 12 | 1 | 2 | UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-galactosamine | UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase | None | None | |
| 2.7.8.36 | undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase | False | 1 | 454 | 2 | 3 | UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate = UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol | UDP-N,N'-diacetylbacillosamine:tritrans,heptacis-undecaprenyl-phosphate N,N'-diacetylbacillosamine transferase | None | PglC | |
| 2.7.8.37 | alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase | False | 7 | 1520 | 6 | 1 | ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine | ATP:methylphosphonate 5-triphosphoribosyltransferase | None | None | |
| 2.7.11.32 | [pyruvate, phosphate dikinase] kinase | False | 198 | 8053 | 2 | 3 | ADP + [pyruvate, phosphate dikinase] = AMP + [pyruvate, phosphate dikinase] phosphate | ADP:[pyruvate, phosphate dikinase] phosphotransferase | None | PPDK regulatory protein (ambiguous); pyruvate; phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous) | |
| 2.7.11.33 | [pyruvate, water dikinase] kinase | False | 206 | 6880 | 0 | 1 | ADP + [pyruvate, water dikinase] = AMP + [pyruvate, water dikinase] phosphate | ADP:[pyruvate, water dikinase] phosphotransferase | None | PSRP (ambiguous); PEPS kinase | |
| 3.2.1.182 | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase | False | 7 | 0 | 0 | 7 | (1) (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + H2O = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + D-glucose;;(2) (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + H2O = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + D-glucose | (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside beta-D-glucosidase | None | DIMBOAGlc hydrolase; DIMBOA glucosidase | |
| 3.2.1.183 | UDP-N-acetylglucosamine 2-epimerase (hydrolysing) | False | 5 | 2009 | 1 | 6 | UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-D-mannosamine + UDP | UDP-N-acetyl-alpha-D-glucosamine hydrolase (2-epimerising) | None | UDP-N-acetylglucosamine 2-epimerase (ambiguous); GNE (gene name); siaA (gene name); neuC (gene name) | |
| 3.2.1.184 | UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) | False | 2 | 226 | 3 | 2 | UDP-N,N'-diacetylbacillosamine + H2O = UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose | UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising) | None | UDP-Bac2Ac4Ac 2-epimerase; NeuC | |
| 3.5.1.111 | 2-oxoglutaramate amidase | False | 2 | 565 | 0 | 1 | 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3 | 5-amino-2,5-dioxopentanoate amidohydrolase | None | omega-amidase (ambiguous) | |
| 3.5.1.112 | 2'-N-acetylparomamine deacetylase | False | 2 | 25 | 0 | 2 | 2'-N-acetylparomamine + H2O = paromamine + acetate | 2'-N-acetylparomamine hydrolase (acetate-forming) | None | btrD (gene name); neoL (gene name); kanN (gene name) | |
| 3.5.1.113 | 2'''-acetyl-6'''-hydroxyneomycin C deacetylase | False | 1 | 0 | 0 | 1 | 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate | 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming) | None | neoL (gene name) | |
| 3.6.1.63 | alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase | False | 1 | 2818 | 0 | 1 | alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate | alpha-D-ribose-1-methylphosphonate-5-triphosphate diphosphohydrolase | None | phnM (gene name) | |
| 3.7.1.20 | 3-fumarylpyruvate hydrolase | False | 1 | 578 | 0 | 4 | 3-fumarylpyruvate + H2O = fumarate + pyruvate | 3-fumarylpyruvate hydrolase | None | nagK (gene name); naaD (gene name) | |
| 4.2.1.135 | UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) | False | 1 | 988 | 0 | 2 | UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O | UDP-N-acetyl-alpha-D-glucosamine hydro-lyase (configuration-retaining; UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose-forming) | None | PglF | |
| 4.2.1.136 | ADP-dependent NAD(P)H-hydrate dehydratase | False | 49 | 39525 | 0 | 7 | (1) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = AMP + phosphate + NADH;;(2) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = AMP + phosphate + NADPH | (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming) | None | (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing); (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming) | |
| 4.2.1.137 | sporulenol synthase | False | 1 | 78 | 0 | 2 | sporulenol = tetraprenyl-beta-curcumene + H2O | tetraprenyl-beta-curcumene---sporulenol cyclase | None | sqhC (gene name) | |
| 4.2.3.134 | 5-phosphooxy-L-lysine phospho-lyase | False | 2 | 3 | 0 | 3 | (5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate | (5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming) | None | 5-phosphohydroxy-L-lysine ammoniophospholyase; AGXT2L2 (gene name); (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming); 5-phosphonooxy-L-lysine phospho-lyase | |
| 4.2.3.135 | Delta6-protoilludene synthase | False | 12 | 1 | 1 | 4 | (2E,6E)-farnesyl diphosphate = Delta6-protoilludene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Delta6-protoilludene-forming) | None | 6-protoilludene synthase | |
| 4.2.3.136 | alpha-isocomene synthase | False | 1 | 3 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-alpha-isocomene-forming) | None | MrTPS2 | |
| 4.2.3.137 | (E)-2-epi-beta-caryophyllene synthase | False | 2 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (E)-2-epi-beta-caryophyllene-forming) | None | 2-epi-(E)-beta-caryophyllene synthase; SmMTPSL26 | |
| 4.2.3.138 | (+)-epi-alpha-bisabolol synthase | False | 1 | 3 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-epi-alpha-bisabolol-forming) | None | None | |
| 4.2.3.139 | valerena-4,7(11)-diene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = valerena-4,7(11)-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, valerena-4,7(11)-diene-forming) | None | VoTPS2; VoTPS7 | |
| 4.2.3.140 | cis-abienol synthase | False | 2 | 1 | 0 | 2 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate | (13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol-forming) | None | Z-abienol synthase; CAS; ABS | |
| 4.3.1.28 | L-lysine cyclodeaminase | False | 1 | 248 | 0 | 3 | L-lysine = L-pipecolate + NH3 | L-lysine ammonia-lyase (cyclizing; ammonia-forming) | None | rapL (gene name); fkbL (gene name); tubZ (gene name); visC (gene name) | |
| 4.3.3.7 | 4-hydroxy-tetrahydrodipicolinate synthase | False | 478 | 50472 | 75 | 44 | pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O | L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming] | None | dihydrodipicolinate synthase (incorrect); dihydropicolinate synthetase (incorrect); dihydrodipicolinic acid synthase (incorrect); L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing); dapA (gene name). | |
| 4.4.1.26 | olivetolic acid cyclase | False | 1 | 0 | 12 | 1 | 3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate | 3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming) | None | OAC | |
| 5.1.3.25 | dTDP-L-rhamnose 4-epimerase | False | 1 | 347 | 0 | 1 | dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose | dTDP-6-deoxy-beta-L-talose 4-epimerase | None | dTDP-4-L-rhamnose 4-epimerase; wbiB (gene name) | |
| 5.1.99.6 | NAD(P)H-hydrate epimerase | False | 125 | 35205 | 0 | 7 | (1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide;;(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate | (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase | None | NAD(P)HX epimerase | |
| 5.2.1.14 | beta-carotene isomerase | False | 3 | 32 | 0 | 3 | all-trans-beta-carotene = 9-cis-beta-carotene | beta-carotene 9-cis-all-trans isomerase | None | DWARF27 (gene name) | |
| 5.4.99.58 | methylornithine synthase | False | 2 | 27 | 0 | 2 | L-lysine = (3R)-3-methyl-D-ornithine | L-lysine carboxy-aminomethylmutase | None | PylB | |
| 1.1.1.344 | dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] | False | 1 | 79 | 0 | 2 | dTDP-6-deoxy-beta-L-talose + NAD(P)+ = dTDP-4-dehydro-beta-L-rhamnose + NAD(P)H + H+ | dTDP-6-deoxy-beta-L-talose:NAD(P)+ 4-oxidoreductase | None | tal (gene name) | |
| 1.1.1.345 | D-2-hydroxyacid dehydrogenase (NAD+) | True | 0 | 0 | 0 | 11 | an (R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ | (R)-2-hydroxycarboxylate:NAD+ oxidoreductase | None | LdhA; HdhD; D-2-hydroxyisocaproate dehydrogenase; R-HicDH; D-HicDH; (R)-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase; (R)-2-hydroxyisocaproate dehydrogenase; D-mandelate dehydrogenase (ambiguous) | |
| 1.1.1.346 | 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) | False | 10 | 2122 | 0 | 5 | 2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+ | 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-L-gulonate-forming) | None | 2,5-diketo-D-gluconate-reductase (ambiguous); YqhE reductase; dkgA (gene name); dkgB (gene name) | |
| 1.3.1.98 | UDP-N-acetylmuramate dehydrogenase | False | 472 | 43230 | 5 | 12 | UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+ | UDP-N-acetyl-alpha-D-muramate:NADP+ oxidoreductase | None | MurB reductase; UDP-N-acetylenolpyruvoylglucosamine reductase; UDP-N-acetylglucosamine-enoylpyruvate reductase; UDP-GlcNAc-enoylpyruvate reductase; uridine diphosphoacetylpyruvoylglucosamine reductase; uridine diphospho-N-acetylglucosamine-enolpyruvate reductase; uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase | |
| 1.5.1.46 | agroclavine dehydrogenase | False | 4 | 0 | 0 | 2 | agroclavine + NADP+ = 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+ | agroclavine:NADP+ oxidoreductase | None | easG (gene name) | |
| 1.7.3.6 | hydroxylamine oxidase (cytochrome) | True | 0 | 0 | 0 | 4 | hydroxylamine + O2 = nitrite + H2O + H+ (overall reaction);;(1a) hydroxylamine + 2 ferricytochrome c = nitroxyl + 2 ferrocytochrome c + 2 H+;;(1b) nitroxyl + 2 ferrocytochrome c + O2 + H+ = nitrite + 2 ferricytochrome c + H2O (spontaneous) | hydroxylamine:oxygen oxidoreductase | None | HAO (ambiguous); hydroxylamine oxidoreductase (ambiguous); hydroxylamine oxidase (misleading) | |
| 1.11.1.22 | hydroperoxy fatty acid reductase | False | 2 | 47 | 0 | 1 | a hydroperoxy fatty acid + NADPH + H+ = a hydroxy fatty acid + NADP+ + H2O | NADPH:hydroperoxy fatty acid oxidoreductase | None | slr1171 (gene name); slr1992 (gene name); hydroperoxy fatty acid:NADPH oxidoreductase | |
| 1.12.1.5 | hydrogen dehydrogenase [NAD(P)+] | False | 2 | 24 | 0 | 1 | H2 + NAD(P)+ = H+ + NAD(P)H | hydrogen:NAD(P)+ oxidoreductase | None | hydrogenase II (ambiguous) | |
| 1.12.98.4 | sulfhydrogenase | False | 4 | 137 | 0 | 14 | H2 + (sulfide)n = hydrogen sulfide + (sulfide)n-1 | H2:polysulfide oxidoreductase | None | sulfur reductase | |
| 1.13.12.20 | noranthrone monooxygenase | False | 1 | 0 | 0 | 1 | norsolorinic acid anthrone + O2 = norsolorinic acid + H2O | norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming) | None | norsolorinate anthrone oxidase | |
| 1.17.1.8 | 4-hydroxy-tetrahydrodipicolinate reductase | False | 564 | 40411 | 19 | 22 | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase | None | dihydrodipicolinate reductase (incorrect); dihydrodipicolinic acid reductase (incorrect); 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase (incorrect); dapB (gene name) | |
| 1.23.1.1 | (+)-pinoresinol reductase | False | 10 | 272 | 7 | 10 | (+)-lariciresinol + NADP+ = (+)-pinoresinol + NADPH + H+ | (+)-lariciresinol:NADP+ oxidoreductase | None | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (+)-pinoresinol/(+)-lariciresinol; (+)-pinoresinol-(+)-lariciresinol reductase; PLR | |
| 1.23.1.2 | (+)-lariciresinol reductase | False | 7 | 269 | 0 | 8 | (-)-secoisolariciresinol + NADP+ = (+)-lariciresinol + NADPH + H+ | (-)-secoisolariciresinol:NADP+ oxidoreductase | None | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (+)-pinoresinol/(+)-lariciresinol; (+)-pinoresinol-(+)-lariciresinol reductase; PLR | |
| 1.23.1.3 | (-)-pinoresinol reductase | False | 6 | 0 | 2 | 4 | (-)-lariciresinol + NADP+ = (-)-pinoresinol + NADPH + H+ | (-)-lariciresinol:NADP+ oxidoreductase | None | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (-)-pinoresinol-(-)-lariciresinol reductase; PLR | |
| 1.23.1.4 | (-)-lariciresinol reductase | False | 4 | 2 | 0 | 5 | (+)-secoisolariciresinol + NADP+ = (-)-lariciresinol + NADPH + H+ | (+)-secoisolariciresinol:NADP+ oxidoreductase | None | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (-)-pinoresinol-(-)-lariciresinol reductase; PLR | |
| 2.1.1.266 | 23S rRNA (adenine2030-N6)-methyltransferase | False | 2 | 10267 | 9 | 1 | S-adenosyl-L-methionine + adenine2030 in 23S rRNA = S-adenosyl-L-homocysteine + N6-methyladenine2030 in 23S rRNA | S-adenosyl-L-methionine:23S rRNA (adenine2030-N6)-methyltransferase | None | YhiR protein; rlmJ (gene name); m6A2030 methyltransferase | |
| 2.1.1.267 | flavonoid 3',5'-methyltransferase | False | 4 | 8 | 0 | 10 | (1) S-adenosyl-L-methionine + a 3'-hydroxyflavonoid = S-adenosyl-L-homocysteine + a 3'-methoxyflavonoid;;(2) S-adenosyl-L-methionine + a 5'-hydroxy-3'-methoxyflavonoid = S-adenosyl-L-homocysteine + a 3',5'-dimethoxyflavonoid | S-adenosyl-L-methionine:flavonoid 3'-O-methyltransferase | None | AOMT; CrOMT2 | |
| 2.1.1.268 | tRNAThr (cytosine32-N3)-methyltransferase | False | 1 | 11 | 0 | 2 | (1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;;(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer | S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase | None | ABP140; Trm140p | |
| 2.3.1.211 | bisdemethoxycurcumin synthase | False | 1 | 0 | 0 | 2 | 2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 | 4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming) | None | CUS; curcuminoid synthase (ambiguous) | |
| 2.3.1.212 | benzalacetone synthase | False | 2 | 2 | 0 | 4 | 4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2 | 4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (4-hydroxybenzalacetone-forming) | None | BAS | |
| 2.3.1.213 | cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase | True | 0 | 0 | 0 | 1 | 1-O-(4-hydroxycinnamoyl)-beta-D-glucose + cyanidin 3-O-(6-O-beta-D-glucosyl-2-O-beta-D-xylosyl-beta-D-galactoside) = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] | 1-O-(4-hydroxycinnamoyl)-beta-D-glucose:cyanidin 3-O-(6-O-beta-D-glucosyl-2-O-beta-D-xylosyl-beta-D-galactoside) 6'''-O-(4-hydroxycinnamoyl)transferase | None | 1-O-(4-hydroxycinnamoyl)-beta-D-glucose:cyanidin 3-O-(2"-O-xylosyl-6"-O-glucosylgalactoside) 6'''-O-(4-hydroxycinnamoyl)transferase | |
| 2.3.1.214 | pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase | False | 1 | 0 | 0 | 1 | malonyl-CoA + 4'''-demalonylsalvianin = CoA + salvianin | malonyl-CoA:4'''-demalonylsalvianin 4'''-O-malonyltransferase | None | malonyl-CoA:anthocyanin 5-glucoside 4'''-O-malonyltransferase; Ss5MaT2 | |
| 2.3.1.215 | anthocyanidin 3-O-glucoside 6''-O-acyltransferase | False | 1 | 7 | 0 | 3 | 4-hydroxycinnamoyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] | 4-hydroxycinnamoyl-CoA:anthocyanin-3-O-glucoside 6''-O-acyltransferase | None | None | |
| 2.3.1.216 | 5,7-dihydroxy-2-methylchromone synthase | False | 1 | 0 | 0 | 1 | 5 malonyl-CoA = 5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + H2O | malonyl-CoA:malonyl-CoA malonyltransferase (5,7-dihydroxy-2-methyl-4H-chromen-4-one-forming) | None | pentaketide chromone synthase | |
| 2.3.1.217 | curcumin synthase | False | 3 | 3 | 0 | 4 | feruloyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + curcumin + CO2 | feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming) | None | CURS; CURS1 (gene name); CURS2 (gene name); CURS3 (gene name) | |
| 2.3.1.218 | phenylpropanoylacetyl-CoA synthase | False | 1 | 0 | 0 | 4 | (1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA;;(2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA | phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating) | None | phenylpropanoyl-diketide-CoA synthase; DCS | |
| 2.3.1.219 | demethoxycurcumin synthase | False | 1 | 0 | 0 | 2 | (1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2;;(2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 | 4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming) | None | CURS3 | |
| 2.3.1.220 | 2,4,6-trihydroxybenzophenone synthase | False | 2 | 0 | 1 | 6 | 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 | malonyl-CoA:benzoyl-CoA malonyltransferase (2,4,6-trihydroxybenzophenone-forming) | None | benzophenone synthase (ambiguous); BPS (ambiguous) | |
| 2.3.1.221 | noranthrone synthase | False | 4 | 7 | 2 | 2 | 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O | malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming) | None | polyketide synthase A (ambiguous); PksA (ambiguous); norsolorinic acid anthrone synthase | |
| 2.3.1.222 | phosphate propanoyltransferase | False | 24 | 5670 | 2 | 3 | propanoyl-CoA + phosphate = CoA + propanoyl phosphate | propanoyl-CoA:phosphate propanoyltransferase | None | PduL | |
| 2.4.1.294 | cyanidin 3-O-galactosyltransferase | False | 3 | 0 | 0 | 3 | UDP-alpha-D-galactose + cyanidin = UDP + cyanidin 3-O-beta-D-galactoside | UDP-alpha-D-galactose:cyanidin 3-O-galactosyltransferase | None | UDP-galactose:cyanidin galactosyltransferase | |
| 2.4.1.295 | anthocyanin 3-O-sambubioside 5-O-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucose + an anthocyanidin 3-O-beta-D-sambubioside = UDP + an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside | UDP-alpha-D-glucose:anthocyanidin-3-O-beta-D-sambubioside 5-O-glucosyltransferase | None | None | |
| 2.4.1.296 | anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucose + an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] = UDP + an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside | UDP-alpha-D-glucose:anthocyanidin-3-O-[3-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucosyltransferase | None | None | |
| 2.4.1.297 | anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase | False | 2 | 31 | 0 | 3 | UDP-alpha-D-glucose + an anthocyanidin 3-O-beta-D-glucoside = UDP + an anthocyanidin 3-O-sophoroside | UDP-alpha-D-glucose:anthocyanidin-3-O-glucoside 2''-O-glucosyltransferase | None | 3GGT | |
| 2.4.1.298 | anthocyanidin 3-O-glucoside 5-O-glucosyltransferase | False | 4 | 5 | 0 | 6 | UDP-alpha-D-glucose + an anthocyanidin 3-O-beta-D-glucoside = UDP + an anthocyanidin 3,5-di-O-beta-D-glucoside | UDP-alpha-D-glucose:anthocyanidin-3-O-beta-D-glucoside 5-O-glucosyltransferase | None | UDP-glucose:anthocyanin 5-O-glucosyltransferase | |
| 2.4.1.299 | cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) | False | 1 | 2 | 0 | 1 | 1-O-sinapoyl-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = sinapate + cyanidin 3,5-di-O-beta-D-glucoside | 1-O-sinapoyl-beta-D-glucose:cyanidin-3-O-beta-D-glucoside 5-O-beta-D-glucosyltransferase | None | AA5GT | |
| 2.4.1.300 | cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) | False | 1 | 1 | 0 | 2 | 1-O-vanilloyl-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = vanillate + cyanidin 3,7-di-O-beta-D-glucoside | 1-O-vanilloyl-beta-D-glucose:cyanidin-3-O-beta-D-glucoside 7-O-beta-D-glucosyltransferase | None | AA7GT | |
| 2.4.2.49 | neamine phosphoribosyltransferase | False | 1 | 4 | 0 | 1 | neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate | neamine:5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferase | None | btrL (gene name); neoM (gene name) | |
| 2.4.2.50 | cyanidin 3-O-galactoside 2''-O-xylosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-xylose + cyanidin 3-O-beta-D-galactoside = UDP + cyanidin 3-O-(beta-D-xylosyl-(1->2)-beta-D-galactoside) | UDP-alpha-D-xylose:cyanidin-3-O-beta-D-galactoside 2''-O-xylosyltransferase | None | CGXT | |
| 2.4.2.51 | anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase | False | 1 | 8 | 0 | 2 | UDP-alpha-D-xylose + an anthocyanidin 3-O-beta-D-glucoside = UDP + an anthocyanidin 3-O-beta-D-sambubioside | UDP-alpha-D-xylose:anthocyanidin-3-O-beta-D-glucoside 2'''-O-xylosyltransferase | None | uridine 5'-diphosphate-xylose:anthocyanidin 3-O-glucose-xylosyltransferase; UGT79B1 | |
| 2.6.1.100 | L-glutamine:2-deoxy-scyllo-inosose aminotransferase | False | 8 | 277 | 2 | 7 | L-glutamine + 2-deoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | L-glutamine:2-deoxy-scyllo-inosose aminotransferase | None | btrR (gene name); neoB (gene name); kanB (gene name) | |
| 2.6.1.101 | L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase | False | 11 | 18 | 0 | 2 | L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine | L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase | None | None | |
| 2.7.7.84 | 2'-5' oligoadenylate synthase | False | 13 | 1606 | 5 | 12 | 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate | ATP:ATP adenylyltransferase (2'-5' linkages-forming) | None | OAS | |
| 2.7.8.38 | archaetidylserine synthase | False | 1 | 30 | 0 | 2 | (1) CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine;;(2) CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine | CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-(O-geranylgeranyl)-sn-glycerol phosphotransferase | None | None | |
| 3.1.4.55 | phosphoribosyl 1,2-cyclic phosphate phosphodiesterase | False | 1 | 974 | 0 | 1 | 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = alpha-D-ribose 1,5-bisphosphate | 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 2-phosphohydrolase (alpha-D-ribose 1,5-bisphosphate-forming) | None | phnP (gene name) | |
| 3.5.4.34 | tRNAAla(adenine37) deaminase | False | 10 | 1796 | 0 | 3 | adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3 | tRNAAla(adenine37) aminohydrolase | None | ADAT1; Tad1p | |
| 3.5.4.35 | tRNA(cytosine8) deaminase | False | 1 | 0 | 0 | 1 | cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3 | tRNA(cytosine8) aminohydrolase | None | CDAT8 | |
| 3.5.4.36 | mRNA(cytosine6666) deaminase | False | 11 | 442 | 1 | 7 | cytosine6666 in apolipoprotein B mRNA + H2O = uracil6666 in apolipoprotein B mRNA + NH3 | mRNA(cytosine6666) aminohydrolase | None | APOBEC-1 (catalytic component of an RNA-editing complex); APOBEC1 (catalytic subunit); apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex); apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex); apoB mRNA editing complex; apolipoprotein B mRNA editing enzyme; REPR | |
| 3.6.1.64 | inosine diphosphate phosphatase | False | 6 | 737 | 0 | 2 | (1) IDP + H2O = IMP + phosphate;;(2) dIDP + H2O = dIMP + phosphate | inosine diphosphate phosphatase | None | (deoxy)inosine diphosphatase; NUDT16 | |
| 4.1.3.42 | (4S)-4-hydroxy-2-oxoglutarate aldolase | False | 0 | 350 | 0 | 4 | (4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate | (4S)-4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming) | None | 2-oxo-4-hydroxyglutarate aldolase (ambiguous); hydroxyketoglutaric aldolase (ambiguous); 4-hydroxy-2-ketoglutaric aldolase (ambiguous); 2-keto-4-hydroxyglutaric aldolase (ambiguous); 4-hydroxy-2-ketoglutarate aldolase (ambiguous); 2-keto-4-hydroxyglutarate aldolase (ambiguous); 2-oxo-4-hydroxyglutaric aldolase (ambiguous); hydroxyketoglutarate aldolase (ambiguous); 2-keto-4-hydroxybutyrate aldolase (ambiguous); 4-hydroxy-2-oxoglutarate glyoxylate-lyase (ambiguous); eda (gene name) | |
| 4.2.3.141 | sclareol synthase | False | 1 | 0 | 0 | 1 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O = sclareol + diphosphate | (13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol-forming) | None | SS | |
| 4.2.3.142 | 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | True | 0 | 0 | 0 | 2 | (2Z,6Z)-farnesyl diphosphate = 7-epizingiberene + diphosphate | (2Z,6Z)-farnesyl-diphosphate lyase (cyclizing; 7-epizingiberene-forming) | None | ShZIS (gene name) | |
| 4.3.99.4 | choline trimethylamine-lyase | False | 1 | 549 | 10 | 3 | choline = trimethylamine + acetaldehyde | choline trimethylamine-lyase (acetaldehyde-forming) | None | cutC (gene name) | |
| 4.7.1.1 | alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase | False | 2 | 3705 | 0 | 2 | alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5'-deoxyadenosine + oxidized electron acceptor | alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane-forming) | None | phnJ (gene name) | |
| 5.3.2.7 | ascopyrone tautomerase | True | 0 | 0 | 0 | 2 | 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose | 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose Delta3-Delta1-isomerase | None | ascopyrone isomerase; ascopyrone intramolecular oxidoreductase; 1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase; APM tautomerase; ascopyrone P tautomerase; APTM | |
| 5.3.2.8 | 4-oxalomesaconate tautomerase | False | 1 | 1814 | 0 | 2 | (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate | 4-oxalomesaconate keto---enol-isomerase | None | GalD | |
| 5.4.3.10 | phenylalanine aminomutase (L-beta-phenylalanine forming) | False | 3 | 0 | 1 | 6 | L-phenylalanine = L-beta-phenylalanine | L-phenylalanine 2,3-aminomutase [(R)-3-amino-3-phenylpropanoate-forming] | None | None | |
| 5.4.3.11 | phenylalanine aminomutase (D-beta-phenylalanine forming) | False | 0 | 19 | 0 | 4 | L-phenylalanine = D-beta-phenylalanine | L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate-forming] | None | admH (gene name); L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate] | |
| 1.1.1.347 | geraniol dehydrogenase (NAD+) | False | 3 | 24 | 0 | 2 | geraniol + NAD+ = geranial + NADH + H+ | geraniol:NAD+ oxidoreductase | None | GeDH; geoA (gene name) | |
| 1.1.1.348 | (3R)-2'-hydroxyisoflavanone reductase | False | 1 | 33 | 0 | 1 | a (4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + NADPH + H+ | (3R)-2'-hydroxyisoflavanone:NADP+ 4-oxidoreductase | None | vestitone reductase; pterocarpin synthase (incorrect); pterocarpan synthase (incorrect) | |
| 1.1.1.412 | 2-alkyl-3-oxoalkanoate reductase | False | 3 | 100 | 0 | 1 | a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+ = an (R)-2-alkyl-3-oxoalkanoate + NADPH + H+ | (2R,3S)-2-alkyl-3-hydroxyalkanoate:NADP+ oxidoreductase | None | oleD (gene name) | |
| 1.1.1.349 | norsolorinic acid ketoreductase | False | 3 | 3 | 0 | 3 | (1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ | (1'S)-averantin:NADP+ oxidoreductase | None | aflD (gene name); nor-1 (gene name) | |
| 1.1.1.350 | ureidoglycolate dehydrogenase (NAD+) | False | 2 | 64 | 0 | 1 | (S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ | (S)-ureidoglycolate:NAD+ oxidoreductase | None | None | |
| 1.1.1.351 | phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating] | False | 0 | 5 | 0 | 4 | 6-phospho-D-gluconate + NAD(P)+ = D-ribulose 5-phosphate + CO2 + NAD(P)H + H+ | 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating) | None | None | |
| 1.1.1.352 | 5'-hydroxyaverantin dehydrogenase | False | 3 | 2 | 0 | 2 | (1) (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH + H+;;(2) (1'S,5'R)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH + H+ | (1'S,5'S)-hydroxyaverantin:NAD+ oxidoreductase | None | HAVN dehydrogenase; adhA (gene name) | |
| 1.1.1.353 | versiconal hemiacetal acetate reductase | False | 1 | 12 | 0 | 1 | (1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+;;(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+;;(3) versiconol + NADP+ = versiconal + NADPH + H+ | versiconol-acetate:NADP+ oxidoreductase | None | VHA reductase; VHA reductase I; VHA reductase II; vrdA (gene name) | |
| 1.2.99.8 | glyceraldehyde dehydrogenase (FAD-containing) | False | 3 | 62 | 0 | 2 | D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor | D-glyceraldehyde:acceptor oxidoreductase (FAD-containing) | None | glyceraldehyde oxidoreductase | |
| 1.3.1.100 | chanoclavine-I aldehyde reductase | False | 3 | 0 | 1 | 1 | dihydrochanoclavine-I aldehyde + NADP+ = chanoclavine-I aldehyde + NADPH + H+ | chanoclavine-I aldehyde:NAD+ oxidoreductase | None | FgaOx3; easA (gene name) | |
| 1.3.1.101 | 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] | False | 3 | 116 | 0 | 1 | 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ | 2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase | None | digeranylgeranylglycerophospholipid reductase; Ta0516m (gene name); DGGGPL reductase; 2,3-digeranylgeranylglycerophospholipid reductase | |
| 1.3.3.13 | albonoursin synthase | False | 1 | 63 | 0 | 2 | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 = albonoursin + 2 H2O2 (overall reaction);;(1a) cyclo(L-leucyl-L-phenylalanyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2;;(1b) cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2 | cyclo(L-leucyl-L-phenylalanyl):oxygen oxidoreductase | None | cyclo(dipeptide):oxygen oxidoreductase; cyclic dipeptide oxidase; AlbA | |
| 1.3.99.33 | urocanate reductase | False | 6 | 1486 | 4 | 1 | dihydrourocanate + acceptor = urocanate + reduced acceptor | dihydrourocanate:acceptor oxidoreductase | None | urdA (gene name) | |
| 1.5.1.47 | dihydromethanopterin reductase [NAD(P)+] | False | 1 | 21 | 0 | 1 | 5,6,7,8-tetrahydromethanopterin + NAD(P)+ = 7,8-dihydromethanopterin + NAD(P)H + H+ | 5,6,7,8-tetrahydromethanopterin:NAD(P)+ 5,6-oxidoreductase | None | DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase | |
| 1.7.1.15 | nitrite reductase (NADH) | False | 5 | 1931 | 0 | 3 | NH3 + 3 NAD+ + 2 H2O = nitrite + 3 NADH + 5 H+ | ammonia:NAD+ oxidoreductase | None | nitrite reductase (reduced nicotinamide adenine dinucleotide); NADH-nitrite oxidoreductase; assimilatory nitrite reductase (ambiguous); nirB (gene name); nirD (gene name) | |
| 1.13.11.74 | 2-aminophenol 1,6-dioxygenase | False | 2 | 47 | 1 | 3 | 2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde | 2-aminophenol:oxygen 1,6-oxidoreductase (ring-opening) | None | amnA (gene name); amnB (gene name); 2-aminophenol:oxygen 1,6-oxidoreductase (decyclizing) | |
| 1.14.11.37 | kanamycin B dioxygenase | False | 1 | 35 | 11 | 1 | kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2 | kanamycin-B,2-oxoglutarate:oxygen oxidoreductase (deaminating, 2'-hydroxylating) | None | kanJ (gene name) | |
| 1.14.13.172 | salicylate 5-hydroxylase | False | 2 | 189 | 1 | 4 | salicylate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O | salicylate,NADH:oxygen oxidoreductase (5-hydroxylating) | None | nagG (gene name); nagH (gene name) | |
| 1.14.15.13 | pulcherriminic acid synthase | False | 1 | 76 | 6 | 2 | cyclo(L-leucyl-L-leucyl) + 6 reduced ferredoxin + 3 O2 = pulcherriminic acid + 6 oxidized ferredoxin + 4 H2O | cyclo(L-leucyl-L-leucyl),reduced-ferredoxin:oxygen oxidoreductase (N-hydroxylating,aromatizing) | None | cyclo-L-leucyl-L-leucyl dipeptide oxidase; CYP134A1; CypX (ambiguous) | |
| 1.14.19.8 | pentalenolactone synthase | False | 2 | 61 | 9 | 3 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O | pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone-forming) | None | penM (gene name); pntM (gene name) | |
| 1.18.1.7 | ferredoxin---NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific) | False | 2 | 165 | 0 | 2 | 2 reduced [2Fe-2S] ferredoxin + NAD(P)+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NAD(P)H | ferredoxin:NAD(P)+ oxidoreductase | None | NADH-ferredoxin(NAP) reductase | |
| 2.1.1.269 | dimethylsulfoniopropionate demethylase | False | 2 | 119 | 0 | 15 | S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate | S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase | None | dmdA (gene name); dimethylsulfoniopropionate-dependent demethylase A | |
| 2.1.1.270 | (+)-6a-hydroxymaackiain 3-O-methyltransferase | False | 2 | 0 | 0 | 3 | S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain = S-adenosyl-L-homocysteine + (+)-pisatin | S-adenosyl-L-methionine:(+)-6a-hydroxymaackiain 3-O-methyltransferase | None | HM3OMT; HMM2 | |
| 2.1.1.271 | cobalt-precorrin-4 methyltransferase | False | 4 | 1146 | 0 | 4 | S-adenosyl-L-methionine + cobalt-precorrin-4 = S-adenosyl-L-homocysteine + cobalt-precorrin-5A | S-adenosyl-L-methionine:cobalt-precorrin-4 C11-methyltransferase | None | CbiF; S-adenosyl-L-methionine:cobalt-precorrin-4 11-methyltransferase | |
| 2.1.1.272 | cobalt-factor III methyltransferase | False | 1 | 94 | 0 | 1 | S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor = S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor | S-adenosyl-L-methionine:cobalt-factor III C17-methyltransferase (ring contracting) | None | CbiH60 (gene name); S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting) | |
| 2.3.1.223 | 3-oxo-5,6-didehydrosuberyl-CoA thiolase | False | 1 | 28 | 0 | 1 | 2,3-didehydroadipoyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-didehydrosuberoyl-CoA | 2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration) | None | paaJ (gene name) | |
| 2.3.2.20 | cyclo(L-leucyl-L-phenylalanyl) synthase | False | 1 | 0 | 1 | 10 | L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl) | L-leucyl-tRNALeu:L-phenylalanyl-tRNAPhe leucyltransferase (cyclizing) | None | AlbC; cFL synthase | |
| 2.3.2.21 | cyclo(L-tyrosyl-L-tyrosyl) synthase | False | 2 | 1 | 0 | 2 | 2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) | L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing) | None | Rv2275 (gene name); cYY synthase; cyclodityrosine synthase | |
| 2.3.2.22 | cyclo(L-leucyl-L-leucyl) synthase | False | 5 | 0 | 1 | 5 | 2 L-leucyl-tRNALeu = 2 tRNALeu + cyclo(L-leucyl-L-leucyl) | L-leucyl-tRNALeu:L-leucyl-tRNALeu leucyltransferase (cyclizing) | None | YvmC; cLL synthase; cyclodileucine synthase | |
| 2.4.2.52 | triphosphoribosyl-dephospho-CoA synthase | False | 76 | 7424 | 0 | 3 | ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine | ATP:3'-dephospho-CoA 5-triphospho-alpha-D-ribosyltransferase | None | 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase; ATP:dephospho-CoA 5-triphosphoribosyl transferase; CitG; ATP:dephospho-CoA 5'-triphosphoribosyl transferase; MdcB; ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase; MadG | |
| 2.4.2.53 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | False | 74 | 3307 | 0 | 2 | UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate | UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,octacis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase | None | undecaprenyl-phosphate Ara4FN transferase; Ara4FN transferase; polymyxin resistance protein PmrF; UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,polycis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase | |
| 2.4.2.54 | beta-ribofuranosylphenol 5'-phosphate synthase | False | 3 | 1301 | 0 | 7 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate | 5-phospho-alpha-D-ribose-1-diphosphate:4-hydroxybenzoate 5-phospho-beta-D-ribofuranosyltransferase (decarboxylating) | None | beta-RFAP synthase (incorrect); beta-RFA-P synthase (incorrect); AF2089 (gene name); MJ1427 (gene name); beta-ribofuranosylhydroxybenzene 5'-phosphate synthase; 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase (incorrect); beta-ribofuranosylaminobenzene 5'-phosphate synthase (incorrect); 5-phospho-alpha-D-ribose 1-diphosphate:4-aminobenzoate 5-phospho-beta-D-ribofuranosyltransferase (decarboxylating) (incorrect) | |
| 2.5.1.104 | N1-aminopropylagmatine synthase | False | 3 | 34 | 0 | 3 | S-adenosyl 3-(methylsulfanyl)propylamine + agmatine = S-methyl-5'-thioadenosine + N1-(3-aminopropyl)agmatine | S-adenosyl 3-(methylsulfanyl)propylamine:agmatine 3-aminopropyltransferase | None | agmatine/cadaverine aminopropyl transferase; ACAPT; PF0127 (gene name); triamine/agmatine aminopropyltransferase; SpeE (ambiguous); agmatine aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:agmatine 3-aminopropyltransferase | |
| 2.5.1.105 | 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase | False | 1 | 162 | 0 | 1 | (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate | (7,8-dihydropterin-6-yl)methyl-diphosphate:4-(beta-D-ribofuranosyl)aniline 5'-phosphate 6-hydroxymethyl-7,8-dihydropterintransferase | None | MJ0301 (gene name); dihydropteroate synthase (ambiguous) | |
| 2.5.1.106 | tryprostatin B synthase | False | 3 | 0 | 0 | 1 | prenyl diphosphate + brevianamide F = diphosphate + tryprostatin B | prenyl-diphosphate:brevianamide-F prenyl-C-2-transferase | None | ftmPT1 (gene name); brevianamide F prenyltransferase (ambiguous); dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase | |
| 2.5.1.107 | verruculogen prenyltransferase | False | 1 | 0 | 0 | 1 | prenyl diphosphate + verruculogen = diphosphate + fumitremorgin A | prenyl-diphosphate:verruculogen dimethylallyl-O-transferase | None | FtmPT3; dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase | |
| 2.7.1.178 | 2-dehydro-3-deoxyglucono/galactono-kinase | False | 2 | 7 | 0 | 3 | (1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate;;(2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate | ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase | None | KDG kinase (ambiguous); KDGK (ambiguous); 2-keto-3-deoxy-D-gluconate kinase (ambiguous) | |
| 2.7.1.179 | kanosamine kinase | False | 1 | 18 | 0 | 1 | ATP + kanosamine = ADP + kanosamine 6-phosphate | ATP:kanosamine 6-phosphotransferase | None | rifN (gene name) | |
| 2.7.7.85 | diadenylate cyclase | False | 80 | 21442 | 55 | 25 | 2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate | ATP:ATP adenylyltransferase (cyclizing) | None | cyclic-di-AMP synthase; dacA (gene name); disA (gene name) | |
| 2.8.3.18 | succinyl-CoA:acetate CoA-transferase | False | 1 | 206 | 14 | 5 | succinyl-CoA + acetate = acetyl-CoA + succinate | succinyl-CoA:acetate CoA-transferase | None | aarC (gene name); SCACT | |
| 3.1.1.94 | versiconal hemiacetal acetate esterase | False | 3 | 3 | 0 | 1 | (1) versiconal hemiacetal acetate + H2O = versiconal + acetate;;(2) versiconol acetate + H2O = versiconol + acetate | versiconal-hemiacetal-acetate O-acetylhydrolase | None | VHA esterase | |
| 3.1.3.89 | 5'-deoxynucleotidase | False | 85 | 12225 | 0 | 2 | a 2'-deoxyribonucleoside 5'-monophosphate + H2O = a 2'-deoxyribonucleoside + phosphate | 2'-deoxyribonucleoside 5'-monophosphate phosphohydrolase | None | yfbR (gene name) | |
| 3.1.4.56 | 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase | False | 1 | 24 | 0 | 1 | (1) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate;;(2) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate | 7,8-dihydroneopterin 2',3'-cyclic phosphate 2'/3'-phosphodiesterase | None | MptB | |
| 3.1.6.19 | (R)-specific secondary-alkylsulfatase (type III) | False | 1 | 0 | 0 | 5 | an (R)-secondary-alkyl sulfate + H2O = an (S)-secondary-alcohol + sulfate | (R)-secondary-alkyl sulfate sulfohydrolase [(S)-secondary-alcohol-forming] | None | S3 secondary alkylsulphohydrolase; Pisa1; secondary alkylsulphohydrolase; (R)-specific sec-alkylsulfatase; sec-alkylsulfatase; (R)-specific secondary-alkylsulfatase; type III (R)-specific secondary-alkylsulfatase | |
| 3.2.1.185 | non-reducing end beta-L-arabinofuranosidase | False | 1 | 391 | 13 | 2 | beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose | beta-L-arabinofuranoside non-reducing end beta-L-arabinofuranosidase | None | HypBA1 | |
| 3.3.2.12 | oxepin-CoA hydrolase | False | 1 | 203 | 5 | 1 | 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde | 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase | None | paaZ (gene name) | |
| 3.5.3.24 | N1-aminopropylagmatine ureohydrolase | False | 4 | 172 | 0 | 2 | N1-(aminopropyl)agmatine + H2O = spermidine + urea | N1-(aminopropyl)agmatine amidinohydrolase | None | None | |
| 3.5.4.37 | double-stranded RNA adenine deaminase | False | 7 | 10 | 17 | 12 | adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3 | double-stranded RNA adenine aminohydrolase | None | ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase | |
| 3.5.4.38 | single-stranded DNA cytosine deaminase | False | 31 | 533 | 23 | 8 | cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3 | single-stranded DNA cytosine aminohydrolase | None | AID; activation-induced deaminase; AICDA (gene name); activation-induced cytidine deaminase | |
| 3.5.4.39 | GTP cyclohydrolase IV | False | 38 | 1253 | 0 | 1 | GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate | GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing) | None | MptA; GTP cyclohydrolase MptA | |
| 3.6.1.65 | (d)CTP diphosphatase | False | 1 | 168 | 0 | 2 | (1) CTP + H2O = CMP + diphosphate;;(2) dCTP + H2O = dCMP + diphosphate | (deoxy)cytidine 5'-triphosphate diphosphohydrolase | None | (d)CTP pyrophosphohydrolase; (d)CTP diphosphohydrolase; nudG (gene name) | |
| 4.1.2.51 | 2-dehydro-3-deoxy-D-gluconate aldolase | False | 3 | 47 | 1 | 1 | 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde | 2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming) | None | Pto1279 (gene name); KDGA; KDG-specific aldolase | |
| 4.2.1.138 | (+)-caryolan-1-ol synthase | False | 1 | 0 | 0 | 1 | (+)-beta-caryophyllene + H2O = (+)-caryolan-1-ol | (+)-beta-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming] | None | GcoA | |
| 4.2.1.139 | pterocarpan synthase | False | 2 | 0 | 0 | 2 | a (4R)-4,2'-dihydroxyisoflavan = a pterocarpan + H2O | (4R)-4,2'-dihydroxyisoflavan hydro-lyase (pterocarpan-forming) | None | medicarpin synthase; medicarpan synthase; 7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase; 2',7-dihydroxy-4'-methoxyisoflavanol dehydratase; DMI dehydratase; DMID; 2'-hydroxyisoflavanol 4,2'-dehydratase; PTS (gene name); 4'-methoxyisoflavan-2',4,7-triol hydro-lyase [(-)-medicarpin-forming] | |
| 4.2.1.140 | gluconate/galactonate dehydratase | False | 2 | 10 | 0 | 2 | (1) D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O;;(2) D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O | D-gluconate/D-galactonate hydro-lyase | None | gluconate dehydratase (ambiguous); Sso3198 (gene name); Pto0485 (gene name) | |
| 4.2.1.141 | 2-dehydro-3-deoxy-D-arabinonate dehydratase | False | 2 | 83 | 0 | 2 | 2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O | 2-dehydro-3-deoxy-D-arabinonate hydro-lyase (2,5-dioxopentanoate-forming) | None | None | |
| 4.2.1.142 | 5'-oxoaverantin cyclase | False | 4 | 0 | 0 | 1 | 5'-oxoaverantin = (1'S,5'S)-averufin + H2O | 5'-oxoaverantin hydro-lyase [(1'S,5'S)-averufin-forming] | None | OAVN cyclase; 5'-oxoaverantin hydro-lyase [(2'S,5'S)-averufin forming] | |
| 4.2.1.143 | versicolorin B synthase | False | 4 | 0 | 0 | 2 | versiconal = versicolorin B + H2O | versiconal hydro-lyase (versicolorin-B-forming) | None | versiconal cyclase; VBS | |
| 4.2.1.144 | 3-amino-5-hydroxybenzoate synthase | False | 1 | 43 | 0 | 2 | 5-amino-5-deoxy-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H2O | 5-amino-5-deoxy-3-dehydroshikimate hydro-lyase (3-amino-5-hydroxybenzoate-forming) | None | AHBA synthase; rifK (gene name) | |
| 4.2.3.143 | kunzeaol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (kunzeaol-forming) | None | TgTPS2 (gene name) | |
| 4.2.99.22 | tuliposide A-converting enzyme | False | 6 | 206 | 0 | 1 | 6-tuliposide A = tulipalin A + D-glucose | 6-tuliposide A D-glucose-lyase (tulipalin-A-forming) | None | tuliposide-converting enzyme; 6-O-(4'-hydroxy-2'-methylenebutyryl)-D-glucose acyltransferase (lactone-forming); TCA; TCEA | |
| 6.3.2.40 | cyclopeptine synthase | False | 2 | 0 | 0 | 0 | 2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine | S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine-forming) | None | None | |
| 6.3.4.21 | nicotinate phosphoribosyltransferase | False | 163 | 34961 | 1 | 14 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) | None | niacin ribonucleotidase; nicotinic acid mononucleotide glycohydrolase; nicotinic acid mononucleotide pyrophosphorylase; nicotinic acid phosphoribosyltransferase; nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase | |
| 6.3.4.22 | tRNAIle2-agmatinylcytidine synthase | False | 22 | 1881 | 3 | 2 | ATP + agmatine + [tRNAIle2]-cytidine34 + H2O = [tRNAIle2]-2-agmatinylcytidine34 + AMP + 2 phosphate | agmatine:[tRNAIle]-cytidine34 ligase | None | TiaS; AF2259; tRNAIle-2-agmatinylcytidine synthetase; tRNAIle-agm2C synthetase; tRNAIle-agmatidine synthetase | |
| 1.1.1.354 | farnesol dehydrogenase (NAD+) | False | 1 | 19 | 0 | 3 | (2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ | (2E,6E)-farnesol:NAD+ 1-oxidoreductase | None | NAD+-farnesol dehydrogenase | |
| 1.1.1.355 | 2'-dehydrokanamycin reductase | False | 1 | 10 | 0 | 1 | kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ | kanamycin A:NADP+ oxidoreductase | None | kanK (gene name, ambiguous) | |
| 1.1.1.356 | GDP-L-colitose synthase | False | 1 | 4 | 0 | 1 | GDP-beta-L-colitose + NAD(P)+ = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+ | GDP-beta-L-colitose:NAD(P)+ 4-oxidoreductase (5-epimerizing) | None | ColC | |
| 1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase | False | 10 | 0 | 3 | 7 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ | 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase | None | 3alpha-hydroxysteroid dehydrogenase; AKR1C4 (gene name); AKR1C2 (gene name); hsdA (gene name) | |
| 1.1.1.358 | 2-dehydropantolactone reductase | False | 2 | 7 | 0 | 3 | (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ | (R)-pantolactone:NADP+ oxidoreductase | None | 2-oxopantoyl lactone reductase; 2-ketopantoyl lactone reductase; ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase | |
| 1.1.1.359 | aldose 1-dehydrogenase [NAD(P)+] | False | 1 | 1 | 0 | 2 | an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ | an aldopyranose:NAD(P)+ 1-oxidoreductase | None | None | |
| 1.1.1.360 | glucose/galactose 1-dehydrogenase | False | 1 | 0 | 0 | 2 | (1) D-glucopyranose + NADP+ = D-glucono-1,5-lactone + NADPH + H+;;(2) D-galactopyranose + NADP+ = D-galactono-1,5-lactone + NADPH + H+ | D-glucose/D-galactose 1-dehydrogenase (NADPH) | None | GdhA; dual-specific glucose/galactose dehydrogenase; glucose (galactose) dehydrogenase; glucose/galactose dehydrogenase | |
| 1.1.5.9 | glucose 1-dehydrogenase (FAD, quinone) | False | 2 | 13 | 5 | 16 | D-glucose + a quinone = D-glucono-1,5-lactone + a quinol | D-glucose:quinone 1-oxidoreductase | None | glucose dehydrogenase (Aspergillus); FAD-dependent glucose dehydrogenase; D-glucose:(acceptor) 1-oxidoreductase; glucose dehydrogenase (acceptor); gdh (gene name) | |
| 1.2.1.87 | propanal dehydrogenase (CoA-propanoylating) | False | 10 | 17 | 0 | 5 | propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ | propanal:NAD+ oxidoreductase (CoA-propanoylating) | None | BphJ | |
| 1.2.1.88 | L-glutamate gamma-semialdehyde dehydrogenase | False | 61 | 33776 | 8 | 39 | L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+ | L-glutamate gamma-semialdehyde:NAD+ oxidoreductase | None | 1-pyrroline-5-carboxylate dehydrogenase; Delta1-pyrroline-5-carboxylate dehydrogenase; 1-pyrroline dehydrogenase; pyrroline-5-carboxylate dehydrogenase; pyrroline-5-carboxylic acid dehydrogenase; L-pyrroline-5-carboxylate-NAD+ oxidoreductase; 1-pyrroline-5-carboxylate:NAD+ oxidoreductase; Delta1-pyrroline-5-carboxylic acid dehydrogenase | |
| 1.3.1.102 | 2-alkenal reductase (NADP+) | False | 1 | 1 | 0 | 5 | an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+ | n-alkanal:NADP+ 2-oxidoreductase | None | NADPH-dependent alkenal/one oxidoreductase; NADPH:2-alkenal alpha,beta-hydrogenase | |
| 1.3.1.103 | 2-haloacrylate reductase | False | 1 | 427 | 0 | 1 | (S)-2-chloropropanoate + NADP+ = 2-chloroacrylate + NADPH + H+ | (S)-2-chloropropanoate:NADP+ oxidoreductase | None | CAA43 (gene name) | |
| 1.6.1.3 | NAD(P)+ transhydrogenase | True | 0 | 0 | 0 | 8 | NADPH + NAD+ = NADP+ + NADH | NADPH:NAD+ oxidoreductase | None | soluble transhydrogenase; pyridine nucleotide transhydrogenase; transhydrogenase (ambiguous); nicotinamide adenine dinucleotide (phosphate) transhydrogenase (ambiguous); NAD+ transhydrogenase (ambiguous); NADH transhydrogenase (misleading); nicotinamide nucleotide transhydrogenase (ambiguous); NADPH-NAD+ transhydrogenase (ambiguous); pyridine nucleotide transferase (ambiguous); NADPH-NAD+ oxidoreductase (ambiguous); NADH-NADP+-transhydrogenase (ambiguous); NADPH:NAD+ transhydrogenase; H+-Thase (ambiguous); non-energy-linked transhydrogenase (ambiguous); sthA (gene name) | |
| 1.8.1.18 | NAD(P)H sulfur oxidoreductase (CoA-dependent) | False | 3 | 0 | 0 | 3 | hydrogen sulfide + NAD(P)+ = sulfur + NAD(P)H + H+ | hydrogen sulfide:NAD(P)+ oxidoreductase (CoA-dependent) | None | NADPH NSR; S0 reductase; coenzyme A-dependent NADPH sulfur oxidoreductase | |
| 1.14.11.38 | verruculogen synthase | False | 3 | 4 | 7 | 1 | fumitremorgin B + 2-oxoglutarate + 2 O2 + reduced acceptor = verruculogen + succinate + CO2 + H2O + acceptor | fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming) | None | fmtF (gene name); FmtOx1 | |
| 1.14.11.39 | L-asparagine hydroxylase | False | 1 | 61 | 0 | 1 | L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2 | L-asparagine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | L-asparagine 3-hydroxylase; AsnO | |
| 1.14.11.40 | enduracididine beta-hydroxylase | False | 1 | 20 | 0 | 1 | L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2 | L-enduracididine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating) | |
| 1.14.11.41 | L-arginine hydroxylase | False | 2 | 2 | 14 | 2 | L-arginine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine + succinate + CO2 | L-arginine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | None | VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating) | |
| 1.14.13.178 | methylxanthine N1-demethylase | False | 1 | 100 | 6 | 2 | (1) caffeine + O2 + NAD(P)H + H+ = theobromine + NAD(P)+ + H2O + formaldehyde;;(2) theophylline + O2 + NAD(P)H + H+ = 3-methylxanthine + NAD(P)+ + H2O + formaldehyde;;(3) paraxanthine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde | caffeine:oxygen oxidoreductase (N1-demethylating) | None | ndmA (gene name) | |
| 1.14.13.179 | methylxanthine N3-demethylase | False | 1 | 10 | 1 | 1 | (1) theobromine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde;;(2) 3-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde | theobromine:oxygen oxidoreductase (N3-demethylating) | None | ndmB (gene name) | |
| 1.14.20.3 | (5R)-carbapenem-3-carboxylate synthase | False | 1 | 9 | 1 | 2 | (3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 = (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O | (3S,5S)-carbapenam-3-carboxylate,2-oxoglutarate:oxygen oxidoreductase (dehydrating) | None | carC (gene name) | |
| 2.1.1.273 | benzoate O-methyltransferase | False | 7 | 4 | 0 | 12 | S-adenosyl-L-methionine + benzoate = S-adenosyl-L-homocysteine + methyl benzoate | S-adenosyl-L-methionine:benzoate O-methyltransferase | None | BAMT; S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase | |
| 2.1.1.274 | salicylate 1-O-methyltransferase | False | 5 | 28 | 0 | 16 | S-adenosyl-L-methionine + salicylate = S-adenosyl-L-homocysteine + methyl salicylate | S-adenosyl-L-methionine:salicylate 1-O-methyltransferase | None | SAMT; S-adenosyl-L-methionine:salicylic acid carboxyl methyltransferase; salicylate carboxymethyltransferase | |
| 2.1.1.275 | gibberellin A9 O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + gibberellin A9 = S-adenosyl-L-homocysteine + methyl gibberellin A9 | S-adenosyl-L-methionine:gibberellin A9 O-methyltransferase | None | GAMT1 | |
| 2.1.1.276 | gibberellin A4 carboxyl methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + gibberellin A4 = S-adenosyl-L-homocysteine + methyl gibberellin A4 | S-adenosyl-L-methionine:gibberellin A4 O-methyltransferase | None | GAMT2; gibberellin A4 O-methyltransferase | |
| 2.1.1.277 | anthranilate O-methyltransferase | False | 3 | 0 | 0 | 1 | S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + O-methyl anthranilate | S-adenosyl-L-methionine:anthranilate O-methyltransferase | None | AAMT | |
| 2.1.1.278 | indole-3-acetate O-methyltransferase | False | 2 | 9 | 0 | 4 | S-adenosyl-L-methionine + (indol-3-yl)acetate = S-adenosyl-L-homocysteine + methyl (indol-3-yl)acetate | S-adenosyl-L-methionine:(indol-3-yl)acetate O-methyltransferase | None | IAA carboxylmethyltransferase; IAMT | |
| 2.1.1.279 | trans-anol O-methyltransferase | False | 1 | 0 | 0 | 2 | (1) S-adenosyl-L-methionine + trans-anol = S-adenosyl-L-homocysteine + trans-anethole;;(2) S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol | S-adenosyl-L-methionine:trans-anol O-methyltransferase | None | AIMT1; S-adenosyl-L-methionine:t-anol/isoeugenol O-methyltransferase; t-anol O-methyltransferase | |
| 2.1.1.280 | selenocysteine Se-methyltransferase | False | 2 | 1 | 0 | 9 | S-methyl-L-methionine + L-selenocysteine = L-methionine + Se-methyl-L-selenocysteine | S-methyl-L-methionine:L-selenocysteine Se-methyltransferase | None | SMT | |
| 2.1.1.281 | phenylpyruvate C3-methyltransferase | False | 1 | 10 | 0 | 2 | S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate | S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase | None | phenylpyruvate Cbeta-methyltransferase; phenylpyruvate methyltransferase; mppJ (gene name) | |
| 2.1.1.282 | tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase | False | 24 | 3280 | 0 | 4 | S-adenosyl-L-methionine + 7-[(3S)-(3-amino-3-carboxypropyl)]-4-demethylwyosine37 in tRNAPhe = S-adenosyl-L-homocysteine + 7-[(3S)-(3-amino-3-carboxypropyl)]wyosine37 in tRNAPhe | S-adenosyl-L-methionine:tRNAPhe 7-[(3S)-(3-amino-3-carboxypropyl)-4-demethylwyosine-N4]-methyltransferase | None | TYW3 (gene name); tRNA-yW synthesizing enzyme-3 | |
| 2.1.1.283 | emodin O-methyltransferase | False | 1 | 0 | 1 | 2 | S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin | S-adenosyl-L-methionine:emodin 8-O-methyltransferase | None | EOMT | |
| 2.1.1.284 | 8-demethylnovobiocic acid C8-methyltransferase | False | 1 | 17 | 1 | 1 | S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid | S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase | None | NovO | |
| 2.1.1.285 | demethyldecarbamoylnovobiocin O-methyltransferase | False | 1 | 56 | 0 | 1 | S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin = S-adenosyl-L-homocysteine + decarbamoylnovobiocin | S-adenosyl-L-methionine:demethyldecarbamoylnovobiocin 4''-O-methyltransferase | None | NovP | |
| 2.1.1.286 | 25S rRNA (adenine2142-N1)-methyltransferase | False | 1 | 32 | 0 | 1 | S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA | S-adenosyl-L-methionine:25S rRNA (adenine2142-N1)-methyltransferase | None | BMT2 (gene name); 25S rRNA m1A2142 methyltransferase | |
| 2.1.1.287 | 25S rRNA (adenine645-N1)-methyltransferase | False | 2 | 8 | 0 | 3 | S-adenosyl-L-methionine + adenine645 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine645 in 25S rRNA | S-adenosyl-L-methionine:25S rRNA (adenine645-N1)-methyltransferase | None | 25S rRNA m1A645 methyltransferase; Rrp8 | |
| 2.1.3.12 | decarbamoylnovobiocin carbamoyltransferase | False | 1 | 349 | 0 | 1 | carbamoyl phosphate + decarbamoylnovobiocin = phosphate + novobiocin | carbamoyl phosphate:decarbamoylnovobiocin 3''-O-carbamoyltransferase | None | novN (gene name) | |
| 2.3.1.224 | acetyl-CoA-benzylalcohol acetyltransferase | False | 4 | 4 | 0 | 3 | (1) acetyl-CoA + benzyl alcohol = CoA + benzyl acetate;;(2) acetyl-CoA + cinnamyl alcohol = CoA + cinnamyl acetate | acetyl-CoA:benzylalcohol O-acetyltransferase | None | BEAT | |
| 2.3.1.225 | protein S-acyltransferase | False | 235 | 60067 | 9 | 9 | palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA | palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase | None | DHHC palmitoyl transferase; S-protein acyltransferase; G-protein palmitoyltransferase | |
| 2.3.1.226 | carboxymethylproline synthase | False | 1 | 4 | 0 | 1 | malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O = CoA + (2S,5S)-5-carboxymethylproline + CO2 | malonyl-CoA:(S)-1-pyrroline-5-carboxylate malonyltransferase (cyclizing) | None | CarB (ambiguous) | |
| 2.4.1.301 | 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase | False | 1 | 775 | 0 | 1 | (1) UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine = UDP + kanamycin A;;(2) UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B;;(3) UDP-alpha-D-kanosamine + paromamine = UDP + kanamycin C;;(4) UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine = UDP + kanamycin X | UDP-alpha-D-kanosamine:2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase | None | kanE (gene name); kanM2 (gene name) | |
| 2.4.1.302 | L-demethylnoviosyl transferase | False | 1 | 62 | 0 | 2 | dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin | dTDP-4-O-demethyl-beta-L-noviose:novobiocic acid 7-O-[4-O-demethyl-L-noviosyl]transferase | None | novM (gene name); dTDP-beta-L-noviose:novobiocic acid 7-O-noviosyltransferase; L-noviosyl transferase | |
| 2.4.1.303 | UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase | False | 1 | 134 | 0 | 1 | UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-galactose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-beta-galactosyltransferase (configuration-inverting) | None | WbbD; WbbD beta3Gal-transferase; UDP-Gal:GlcNAc-R beta1,3-galactosyltransferase; UDP-Gal:GlcNAcalpha-pyrophosphate-R beta1,3-galactosyltransferase; UDP-Gal:GlcNAc-R galactosyltransferase | |
| 2.4.1.304 | UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase | False | 1 | 19 | 0 | 1 | UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-galactose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-1,4-galactosyltransferase | None | WfeD; UDP-Gal:GlcNAc-R 1,4-Gal-transferase; UDP-Gal:GlcNAc-pyrophosphate-lipid beta-1,4-galactosyltransferase | |
| 2.4.1.305 | UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase | False | 2 | 389 | 0 | 1 | UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-glucose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-1,3-glucosyltransferase | None | WfaP; WfgD; UDP-Glc:GlcNAc-pyrophosphate-lipid beta-1,3-glucosyltransferase; UDP-Glc:GlcNAc-diphosphate-lipid beta-1,3-glucosyltransferase | |
| 2.4.1.306 | UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase | False | 2 | 18 | 1 | 1 | UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-1,3-N-acetyl-D-galactosyltransferase | None | WbnH | |
| 2.4.1.308 | GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase | False | 1 | 70 | 0 | 1 | GDP-beta-L-fucose + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol | GDP-beta-L-fucose:beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol alpha-1,2-fucosyltransferase | None | WbnK | |
| 2.4.1.309 | UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-galactose + alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-Gal-(1->3)-(alpha-L-Fuc-(1->2))-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-galactose:alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol alpha-1,3-galactosyltransferase | None | WbnI | |
| 2.5.1.108 | 2-(3-amino-3-carboxypropyl)histidine synthase | False | 29 | 7122 | 4 | 4 | S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] | S-adenosyl-L-methionine:L-histidine-[translation elongation factor 2] 2-[(3S)-3-amino-3-carboxypropyl]transferase | None | Dph2 | |
| 2.5.1.109 | brevianamide F prenyltransferase (deoxybrevianamide E-forming) | False | 2 | 0 | 2 | 4 | prenyl diphosphate + brevianamide F = diphosphate + deoxybrevianamide E | prenyl-diphosphate:brevianamide-F 2-methylbut-3-en-2-yl-C-2-transferase | None | NotF; BrePT; brevianamide F reverse prenyltransferase; dimethylallyl-diphosphate:brevianamide-F tert-dimethylallyl-C-2-transferase | |
| 2.5.1.110 | 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase | False | 3 | 0 | 0 | 1 | prenyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B | prenyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C prenyl-N-1-transferase | None | ftmH (gene name); FtmPT2; dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase | |
| 2.6.1.102 | GDP-perosamine synthase | False | 3 | 346 | 0 | 3 | GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate | GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase | None | RfbE; GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase; GDP-perosamine synthetase; PerA; GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase | |
| 2.6.99.3 | O-ureido-L-serine synthase | False | 1 | 12 | 2 | 1 | O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate | O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase | None | dcsD (gene name) | |
| 2.7.7.86 | cyclic GMP-AMP synthase | False | 18 | 42 | 144 | 4 | ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction);;(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;;(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate | ATP:GTP adenylyltransferase (cyclizing) | None | cGAMP synthase; cGAS | |
| 2.7.7.87 | L-threonylcarbamoyladenylate synthase | False | 167 | 52144 | 4 | 5 | L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O | ATP:L-threonyl,HCO3- adenylyltransferase | None | yrdC (gene name); Sua5; ywlC (gene name); ATP:L-threonyl,bicarbonate adenylyltransferase | |
| 2.7.8.39 | archaetidylinositol phosphate synthase | False | 4 | 703 | 0 | 4 | CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate = CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate | CDP-2,3-bis-(O-phytanyl)-sn-glycerol:1L-myo-inositol 1-phosphate 1-sn-archaetidyltransferase | None | AIP synthase | |
| 2.7.8.40 | UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase | False | 2 | 501 | 0 | 1 | UDP-N-acetyl-alpha-D-galactosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-galactosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-galactosaminephosphotransferase | None | WecP; UDP-GalNAc:polyprenol-P GalNAc-1-P transferase; UDP-GalNAc:undecaprenyl-phosphate GalNAc-1-phosphate transferase | |
| 3.1.3.90 | maltose 6'-phosphate phosphatase | False | 1 | 103 | 0 | 1 | maltose 6'-phosphate + H2O = maltose + phosphate | maltose 6'-phosphate phosphohydrolase | None | maltose 6'-P phosphatase; mapP (gene name) | |
| 3.5.3.25 | Nomega-hydroxy-L-arginine amidinohydrolase | False | 1 | 15 | 11 | 1 | Nomega-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea | Nomega-hydroxy-L-arginine amidinohydrolase | None | dcsB (gene name) | |
| 4.1.2.52 | 4-hydroxy-2-oxoheptanedioate aldolase | False | 26 | 2231 | 12 | 1 | 4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde | 4-hydroxy-2-oxoheptanedioate succinate-semialdehyde-lyase (pyruvate-forming) | None | 2,4-dihydroxyhept-2-enedioate aldolase; HHED aldolase; 4-hydroxy-2-ketoheptanedioate aldolase; HKHD aldolase; HpcH; HpaI; 4-hydroxy-2-oxoheptanedioate succinate semialdehyde lyase (pyruvate-forming) | |
| 4.1.2.53 | 2-keto-3-deoxy-L-rhamnonate aldolase | False | 33 | 604 | 0 | 4 | 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde | 2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming) | None | KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; YfaU; 2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming); 2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming) | |
| 4.1.3.43 | 4-hydroxy-2-oxohexanoate aldolase | False | 8 | 154 | 0 | 2 | (S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate | (S)-4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming) | None | BphI | |
| 4.1.99.20 | 3-amino-4-hydroxybenzoate synthase | False | 2 | 48 | 0 | 1 | 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + phosphate + 2 H2O | 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate hydro-lyase (cyclizing, 3-amino-4-hydroxybenzoate-forming) | None | 3,4-AHBA synthase; griH (gene name) | |
| 5.1.1.19 | O-ureido-serine racemase | False | 1 | 0 | 1 | 1 | O-ureido-L-serine = O-ureido-D-serine | (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase | None | dcsC (gene name) | |
| 5.4.2.12 | phosphoglycerate mutase (2,3-diphosphoglycerate-independent) | False | 341 | 35281 | 11 | 48 | 2-phospho-D-glycerate = 3-phospho-D-glycerate | D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-independent) | None | cofactor independent phosphoglycerate mutase; 2,3-diphosphoglycerate-independent phosphoglycerate mutase; phosphoglycerate phosphomutase (ambiguous); phosphoglyceromutase (ambiguous); monophosphoglycerate mutase (ambiguous); monophosphoglyceromutase (ambiguous); GriP mutase (ambiguous); PGA mutase (ambiguous); iPGM; iPGAM; PGAM-i | |
| 6.3.1.15 | 8-demethylnovobiocic acid synthase | False | 1 | 18 | 0 | 1 | ATP + 4-hydroxy-3-prenylbenzoate + 3-amino-4,7-dihydroxycoumarin = AMP + diphosphate + 8-demethylnovobiocic acid | 4-hydroxy-3-prenylbenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming) | None | novL (gene name); novobiocin ligase; novobiocic acid synthetase (misleading); 8-desmethyl-novobiocic acid synthetase; 8-demethylnovobiocic acid synthetase; 3-dimethylallyl-4-hydroxybenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming) | |
| 6.3.3.5 | O-ureido-D-serine cyclo-ligase | False | 1 | 92 | 1 | 1 | O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate | O-ureido-D-serine cyclo-ligase (D-cycloserine-forming) | None | dcsG (gene name) | |
| 6.3.4.23 | formate---phosphoribosylaminoimidazolecarboxamide ligase | False | 37 | 1196 | 0 | 1 | ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming) | None | 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase; 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase; purP (gene name) | |
| 5.5.1.22 | (-)-bornyl diphosphate synthase | True | 0 | 0 | 0 | 2 | geranyl diphosphate = (-)-bornyl diphosphate | (-)-bornyl-diphosphate lyase (ring-opening) | None | bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (-)-bornyl pyrophosphate cyclase; bornyl diphosphate synthase; geranyl-diphosphate cyclase (ambiguous); (-)-bornyl-diphosphate lyase (decyclizing) | |
| 1.1.1.361 | glucose-6-phosphate 3-dehydrogenase | False | 1 | 207 | 0 | 1 | D-glucose 6-phosphate + NAD+ = 3-dehydro-D-glucose 6-phosphate + NADH + H+ | D-glucose-6-phosphate:NAD+ oxidoreductase | None | ntdC (gene name) | |
| 1.1.1.362 | aklaviketone reductase | False | 1 | 32 | 0 | 1 | aklavinone + NADP+ = aklaviketone + NADPH + H+ | aklavinone:NADP+ oxidoreductase | None | dauE (gene name); aknU (gene name) | |
| 1.1.1.363 | glucose-6-phosphate dehydrogenase [NAD(P)+] | False | 5 | 84 | 0 | 6 | D-glucose 6-phosphate + NAD(P)+ = 6-phospho-D-glucono-1,5-lactone + NAD(P)H + H+ | D-glucose-6-phosphate:NAD(P)+ 1-oxidoreductase | None | G6PDH; G6PD; Glc6PD | |
| 1.1.3.45 | aclacinomycin-N oxidase | False | 1 | 41 | 0 | 2 | aclacinomycin N + O2 = aclacinomycin A + H2O2 | aclacinomycin-N:oxygen oxidoreductase | None | AknOx (ambiguous); aclacinomycin oxidoreductase (ambiguous) | |
| 1.2.7.11 | 2-oxoacid oxidoreductase (ferredoxin) | False | 12 | 3523 | 0 | 9 | a 2-oxocarboxylate + CoA + 2 oxidized ferredoxin = an acyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+ | 2-oxocarboxylate:ferredoxin 2-oxidoreductase (decarboxylating, CoA-acylating) | None | OFOR | |
| 1.3.1.104 | enoyl-[acyl-carrier-protein] reductase (NADPH) | False | 22 | 5649 | 2 | 4 | an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ | acyl-[acyl-carrier protein]:NADP+ oxidoreductase | None | acyl-ACP dehydrogenase (ambiguous); enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADPH 2-enoyl Co A reductase; enoyl-ACP reductase (ambiguous); fabL (gene name) | |
| 1.3.3.14 | aclacinomycin-A oxidase | False | 1 | 18 | 0 | 1 | aclacinomycin A + O2 = aclacinomycin Y + H2O2 | aclacinomycin-A:oxygen oxidoreductase | None | AknOx (ambiguous); aclacinomycin oxidoreductase (ambiguous) | |
| 1.5.5.2 | proline dehydrogenase | False | 26 | 27335 | 21 | 14 | L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol | L-proline:quinone oxidoreductase | None | L-proline dehydrogenase; L-proline:(acceptor) oxidoreductase | |
| 1.6.3.2 | NAD(P)H oxidase (H2O-forming) | False | 1 | 0 | 0 | 3 | 2 NAD(P)H + 2 H+ + O2 = 2 NAD(P)+ + 2 H2O | NAD(P)H:oxygen oxidoreductase (H2O-forming) | None | None | |
| 1.6.3.3 | NADH oxidase (H2O2-forming) | False | 0 | 24 | 0 | 11 | NADH + H+ + O2 = NAD+ + H2O2 | NADH:oxygen oxidoreductase (H2O2-forming) | None | NOX-1; H2O2-forming NADH oxidase | |
| 1.6.3.4 | NADH oxidase (H2O-forming) | False | 11 | 691 | 0 | 12 | 2 NADH + 2 H+ + O2 = 2 NAD+ + 2 H2O | NADH:oxygen oxidoreductase (H2O-forming) | None | H2O-forming NADH oxidase; Nox-2 | |
| 1.8.1.19 | sulfide dehydrogenase | False | 2 | 257 | 0 | 1 | hydrogen sulfide + (sulfide)n + NADP+ = (sulfide)n+1 + NADPH + H+ | hydrogen sulfide,polysulfide:NADP+ oxidoreductase | None | SuDH | |
| 1.13.11.76 | 2-amino-5-chlorophenol 1,6-dioxygenase | False | 1 | 17 | 0 | 1 | 2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde | 2-amino-5-chlorophenol:oxygen 1,6-oxidoreductase (ring-opening) | None | cnbC (gene name); 2-amino-5-chlorophenol:oxygen 1,6-oxidoreductase (decyclizing) | |
| 1.13.12.21 | tetracenomycin-F1 monooxygenase | False | 1 | 59 | 0 | 1 | tetracenomycin F1 + O2 = tetracenomycin D3 + H2O | tetracenomycin-F1:oxygen C5-monooxygenase | None | tcmH (gene name) | |
| 1.14.11.42 | tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase | False | 4 | 11 | 0 | 1 | 7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2 | tRNAPhe 7-(3-amino-3-carboxypropyl)wyosine37,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) | None | TYW5; tRNA yW-synthesizing enzyme 5 | |
| 1.14.11.43 | (S)-dichlorprop dioxygenase (2-oxoglutarate) | False | 2 | 21 | 0 | 2 | (1) (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + pyruvate + succinate + CO2;; (2) (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2 | (S)-2-(4-chloro-2-methylphenoxy)propanoate,2-oxoglutarate:oxygen oxidoreductase (pyruvate-forming) | None | SdpA; alpha-ketoglutarate-dependent (S)-dichlorprop dioxygenase; (S)-phenoxypropionate/alpha-ketoglutarate-dioxygenase; 2-oxoglutarate-dependent (S)-dichlorprop dioxygenase; (S)-mecoprop dioxygenase; 2-oxoglutarate-dependent (S)-mecoprop dioxygenase | |
| 1.14.11.44 | (R)-dichlorprop dioxygenase (2-oxoglutarate) | False | 2 | 66 | 7 | 2 | (1) (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + pyruvate + succinate + CO2;; (2) (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2 | (R)-2-(4-chloro-2-methylphenoxy)propanoate,2-oxoglutarate:oxygen oxidoreductase (pyruvate-forming) | None | RdpA; alpha-ketoglutarate-dependent (R)-dichlorprop dioxygenase; (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase; 2-oxoglutarate-dependent (R)-dichlorprop dioxygenase; (R)-mecoprop dioxygenase; 2-oxoglutarate-dependent (R)-mecoprop dioxygenase | |
| 1.14.13.180 | aklavinone 12-hydroxylase | False | 3 | 52 | 0 | 2 | aklavinone + NADPH + H+ + O2 = epsilon-rhodomycinone + NADP+ + H2O | aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating) | None | DnrF; RdmE; aklavinone 11-hydroxylase (incorrect) | |
| 1.14.13.181 | 13-deoxydaunorubicin hydroxylase | False | 3 | 3 | 0 | 2 | (1) 13-deoxydaunorubicin + NADPH + H+ + O2 = 13-dihydrodaunorubicin + NADP+ + H2O;; (2) 13-dihydrodaunorubicin + NADPH + H+ + O2 = daunorubicin + NADP+ + 2 H2O | 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) | None | DoxA | |
| 1.14.13.182 | 2-heptyl-3-hydroxy-4(1H)-quinolone synthase | False | 5 | 41 | 0 | 1 | 2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O | 2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating) | None | PqsH; 2-heptyl-3,4-dihydroxyquinoline synthase | |
| 1.14.14.14 | aromatase | False | 24 | 1365 | 5 | 10 | (1) testosterone + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = 17beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH---hemoprotein reductase] (overall reaction);;(1a) testosterone + O2 + [reduced NADPH---hemoprotein reductase] = 19-hydroxytestosterone + H2O + [oxidized NADPH---hemoprotein reductase];;(1b) 19-hydroxytestosterone + O2 + [reduced NADPH---hemoprotein reductase] = 19-oxotestosterone + 2 H2O + [oxidized NADPH---hemoprotein reductase];;(1c) 19-oxotestosterone + O2 + [reduced NADPH---hemoprotein reductase] = 17beta-estradiol + formate + H2O + [oxidized NADPH---hemoprotein reductase];;(2) androst-4-ene-3,17-dione + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = estrone + formate + 4 H2O + 3 [oxidized NADPH---hemoprotein reductase] (overall reaction);;(2a) androst-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H2O + [oxidized NADPH---hemoprotein reductase];;(2b) 19-hydroxyandrost-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + 2 H2O + [oxidized NADPH---hemoprotein reductase];;(2c) 19-oxoandrost-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = estrone + formate + H2O + [oxidized NADPH---hemoprotein reductase] | testosteronel,NADPH---hemoprotein reductase:oxygen oxidoreductase (17beta-estradiol-forming) | None | CYP19A1 (gene name); estrogen synthetase (incorrect) | |
| 1.14.99.48 | heme oxygenase (staphylobilin-producing) | False | 25 | 174 | 2 | 2 | (1) protoheme + 5 reduced acceptor + 4 O2 = beta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O;;(2) protoheme + 5 reduced acceptor + 4 O2 = delta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O | protoheme,hydrogen-donor:oxygen oxidoreductase (delta/beta-methene-oxidizing, hydroxylating) | None | haem oxygenase (ambiguous); heme oxygenase (decyclizing) (ambiguous); heme oxidase (ambiguous); haem oxidase (ambiguous); heme oxygenase (ambiguous); isdG (gene name); isdI (gene name) | |
| 2.1.1.288 | aklanonic acid methyltransferase | False | 2 | 101 | 0 | 1 | S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate | S-adenosyl-L-methionine:aklanonate O-methyltransferase | None | DauC; AAMT | |
| 2.3.1.227 | GDP-perosamine N-acetyltransferase | False | 1 | 20 | 0 | 1 | acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose | acetyl-CoA:GDP-4-amino-4,6-dideoxy-alpha-D-mannose N-acetyltransferase | None | perB (gene name); GDP-alpha-D-perosamine N-acetyltransferase | |
| 2.3.1.228 | isovaleryl-homoserine lactone synthase | False | 1 | 25 | 0 | 2 | isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone | isovaleryl-CoA:S-adenosyl-L-methionine isovaleryltranserase (lactone-forming, methylthioadenosine-releasing) | None | IV-HSL synthase; BjaI | |
| 2.3.1.229 | 4-coumaroyl-homoserine lactone synthase | False | 1 | 19 | 1 | 1 | 4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone | 4-coumaroyl-CoA:S-adenosyl-L-methionine trans-4-coumaroyltranserase (lactone-forming, methylthioadenosine-releasing) | None | p-coumaryl-homoserine lactone synthase; RpaI | |
| 2.5.1.111 | 4-hydroxyphenylpyruvate 3-dimethylallyltransferase | False | 2 | 0 | 0 | 3 | prenyl diphosphate + 3-(4-hydroxyphenyl)pyruvate = diphosphate + 3-(4-hydroxy-3-prenylphenyl)pyruvate | prenyl-diphosphate:3-(4-hydroxyphenyl)pyruvate 3'-prenyltransferase | None | CloQ; 4HPP dimethylallyltransferase; NovQ; dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase | |
| 3.1.1.95 | aclacinomycin methylesterase | False | 1 | 131 | 0 | 1 | aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol | aclacinomycin T acylhydrolase | None | RdmC; aclacinomycin methyl esterase | |
| 3.1.3.91 | 7-methylguanosine nucleotidase | False | 14 | 15 | 3 | 2 | (1) N7-methyl-GMP + H2O = N7-methyl-guanosine + phosphate;;(2) CMP + H2O = cytidine + phosphate | N7-methyl-GMP phosphohydrolase | None | cytosolic nucleotidase III-like; cNIII-like; N7-methylguanylate 5'-phosphatase | |
| 3.1.3.92 | kanosamine-6-phosphate phosphatase | False | 1 | 21 | 0 | 1 | kanosamine 6-phosphate + H2O = kanosamine + phosphate | kanosamine-6-phosphate phosphohydrolase | None | ntdB (gene name) | |
| 3.2.1.186 | protodioscin 26-O-beta-D-glucosidase | False | 2 | 1 | 0 | 3 | protodioscin + H2O = 26-deglucoprotodioscin + D-glucose | protodioscin glucohydrolase | None | F26G; torvosidase; CSF26G1; furostanol glycoside 26-O-beta-D-glucosidase; furostanol 26-O-beta-D-glucoside glucohydrolase | |
| 4.1.2.54 | L-threo-3-deoxy-hexylosonate aldolase | False | 2 | 11 | 0 | 2 | 2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde | 2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming) | None | GAAC; LGA1 | |
| 4.1.3.44 | tRNA 4-demethylwyosine synthase (AdoMet-dependent) | False | 13 | 4968 | 1 | 4 | N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O | tRNAPhe N1-methylguanine,pyruvate acetaldehyde-lyase (tRNAPhe 4-demethylwyosine-forming, decarboxylating, dehydrating) | None | TYW1 | |
| 4.2.1.145 | capreomycidine synthase | False | 1 | 82 | 0 | 2 | (2S,3S)-3-hydroxyarginine = (2S,3R)-capreomycidine + H2O | (2S,3S)-3-hydroxyarginine hydro-lyase (cyclizing, (2S,3R)-capreomycidine-forming) | None | VioD (ambiguous) | |
| 4.2.1.146 | L-galactonate dehydratase | False | 1 | 1 | 0 | 3 | L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O | L-galactonate hydro-lyase (2-dehydro-3-deoxy-L-galactonate-forming) | None | LGD1 | |
| 4.2.3.144 | geranyllinalool synthase | False | 2 | 2 | 0 | 5 | geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [(E,E)-geranyllinalool-forming] | None | TPS04/GES; GES | |
| 5.1.3.26 | N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase | False | 1 | 165 | 0 | 1 | N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol | N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase | None | GlcNAc-P-P-Und epimerase; GlcNAc-P-P-Und 4-epimerase; gne (gene name) | |
| 5.3.1.29 | ribose-1,5-bisphosphate isomerase | False | 8 | 1242 | 15 | 2 | alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate | alpha-D-ribose 1,5-bisphosphate aldose-ketose-isomerase | None | R15P isomerase; ribulose 1,5-bisphosphate synthase; RuBP synthase | |
| 5.4.99.59 | dTDP-fucopyranose mutase | False | 1 | 15 | 0 | 1 | dTDP-alpha-D-fucopyranose = dTDP-alpha-D-fucofuranose | dTDP-alpha-D-fucopyranose furanomutase | None | Fcf2 | |
| 5.5.1.23 | aklanonic acid methyl ester cyclase | False | 3 | 19 | 0 | 3 | aklaviketone = methyl aklanonate | aklaviketone lyase (ring-opening) | None | dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing) | |
| 6.3.3.6 | carbapenam-3-carboxylate synthase | False | 1 | 6 | 0 | 2 | ATP + (2S,5S)-5-carboxymethylproline = AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate | (2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming) | None | CarA (ambiguous); CPS (ambiguous); carbapenam-3-carboxylate ligase; 6-methyl-(2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming) | |
| 6.5.1.5 | RNA 3'-terminal-phosphate cyclase (GTP) | False | 1 | 1 | 0 | 1 | GTP + [RNA]-3'-(3'-phospho-ribonucleoside) = GMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside (overall reaction);;(1a) GTP + [RNA 3'-phosphate cyclase]-L-histidine = 5'-guanosyl [RNA 3'-phosphate cyclase]-Ntau-phosphono-L-histidine + diphosphate;;(1b) 5'-guanosyl [RNA 3'-phosphate cyclase]-Ntau-phosphono-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside) = [RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoguanosine);;(1c) [RNA]-3'-ribonucleoside-3'-(5'-diphosphoguanosine) = [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + GMP | RNA-3'-phosphate:RNA ligase (cyclizing, GMP-forming) | None | Pf-Rtc; RNA-3'-phosphate cyclase (GTP) | |
| 1.1.1.364 | dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase | False | 2 | 101 | 0 | 1 | dTDP-6-deoxy-alpha-D-allose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NAD(P)H + H+ | dTDP-6-deoxy-alpha-D-allose:NAD(P)+ oxidoreductase | None | dTDP-4-dehydro-6-deoxygulose reductase; tylD (gene name); gerKI (gene name); chmD (gene name); mydI (gene name) | |
| 1.1.1.365 | D-galacturonate reductase | False | 2 | 42 | 0 | 9 | L-galactonate + NADP+ = D-galacturonate + NADPH + H+ | L-galactonate:NADP+ oxidoreductase | None | GalUR; gar1 (gene name) | |
| 1.1.1.366 | L-idonate 5-dehydrogenase (NAD+) | False | 1 | 1 | 0 | 2 | L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+ | L-idonate:NAD+ oxidoreductase | None | None | |
| 1.1.98.4 | F420H2:quinone oxidoreductase | True | 0 | 0 | 0 | 2 | a quinol + oxidized coenzyme F420 = a quinone + reduced coenzyme F420 | quinol:coenzyme-F420 oxidoreductase | None | FqoF protein | |
| 1.1.98.5 | secondary-alcohol dehydrogenase (coenzyme-F420) | True | 0 | 0 | 0 | 2 | R-CHOH-R' + oxidized coenzyme F420 = R-CO-R' + reduced coenzyme F420 | secondary-alcohol:coenzyme F420 oxidoreductase | None | F420-dependent alcohol dehydrogenase; secondary alcohol:F420 oxidoreductase; F420-dependent secondary alcohol dehydrogenase | |
| 1.1.99.39 | D-2-hydroxyglutarate dehydrogenase | False | 14 | 1603 | 0 | 4 | (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor | (R)-2-hydroxyglutarate:acceptor 2-oxidoreductase | None | D2HGDH (gene name) | |
| 1.3.1.105 | 2-methylene-furan-3-one reductase | False | 4 | 30 | 0 | 3 | 4-hydroxy-2,5-dimethylfuran-3(2H)-one + NADP+ = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + NADPH + H+ | 4-hydroxy-2,5-dimethylfuran-3(2H)-one:NADP+ oxidoreductase | None | FaEO; SIEO; enone oxidoreductase; 4-hydroxy-2,5-dimethylfuran-3(2H)-one:NAD(P)+ oxidoreductase | |
| 1.3.8.11 | cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) | False | 2 | 16 | 0 | 2 | cyclohexane-1-carbonyl-CoA + electron-transfer flavoprotein = cyclohex-1-ene-1-carbonyl-CoA + reduced electron-transfer flavoprotein | cyclohexane-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase | None | aliB (gene name); cyclohexane-1-carbonyl-CoA dehydrogenase (ambiguous) | |
| 1.5.3.22 | coenzyme F420H2 oxidase | False | 4 | 1 | 0 | 2 | 2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O | reduced coenzyme F420:oxygen oxidoreductase | None | FprA | |
| 1.5.7.2 | coenzyme F420 oxidoreductase (ferredoxin) | False | 1 | 0 | 0 | 2 | reduced coenzyme F420 + 2 oxidized ferredoxin = oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+ | coenzyme F420:ferredoxin oxidoreductase | None | Fd:F420 oxidoreductase; FpoF protein; ferredoxin:F420 oxidoreductase | |
| 1.13.11.77 | oleate 10S-lipoxygenase | False | 1 | 0 | 0 | 3 | (1) oleate + O2 = (8E,10S)-10-hydroperoxyoctadeca-8-enoate;;(2) linoleate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate;;(3) alpha-linolenate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate | oleate:oxygen (10S)-oxidoreductase | None | 10S-DOX; (10S)-dioxygenase; 10S-dioxygenase | |
| 2.1.1.289 | cobalt-precorrin-7 (C5)-methyltransferase | False | 4 | 940 | 0 | 2 | S-adenosyl-L-methionine + cobalt-precorrin-7 = S-adenosyl-L-homocysteine + cobalt-precorrin-8 | S-adenosyl-L-methionine:precorrin-7 C5-methyltransferase | None | CbiE | |
| 2.1.1.290 | tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase | False | 14 | 1807 | 0 | 1 | S-adenosyl-L-methionine + 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe = S-adenosyl-L-homocysteine + 7-[(3S)-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe | S-adenosyl-L-methionine:tRNAPhe {7-[(3S)-3-amino-3-carboxypropyl]wyosine37-O}-methyltransferase | None | TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous) | |
| 2.1.1.291 | (R,S)-reticuline 7-O-methyltransferase | False | 1 | 2 | 0 | 1 | (1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine;;(2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine | S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase | None | None | |
| 2.1.1.292 | carminomycin 4-O-methyltransferase | False | 2 | 2 | 11 | 2 | S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin | S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase | None | DnrK; DauK | |
| 2.1.1.293 | 6-hydroxytryprostatin B O-methyltransferase | False | 3 | 5 | 0 | 1 | S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A | S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase | None | ftmD (gene name) | |
| 2.3.1.230 | 2-heptyl-4(1H)-quinolone synthase | False | 1 | 2 | 0 | 1 | octanoyl-CoA + (2-aminobenzoyl)acetate = 2-heptyl-4-quinolone + CoA + CO2 + H2O (overall reaction);;(1a) octanoyl-CoA + L-cysteinyl-[PqsC protein] = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA;;(1b) S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein];;(1c) 1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4-quinolone + H2O | octanoyl-CoA:(2-aminobenzoyl)acetate octanoyltransferase | None | pqsBC (gene names); malonyl-CoA:anthraniloyl-CoA C-acetyltransferase (decarboxylating) | |
| 2.3.1.231 | tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase | False | 14 | 1807 | 0 | 1 | S-adenosyl-L-methionine + 7-[(3S)-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe + CO2 = S-adenosyl-L-homocysteine + wybutosine37 in tRNAPhe | S-adenosyl-L-methionine:tRNAPhe {7-[(3S)-3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methyltransferase (carbon dioxide-adding) | None | TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous) | |
| 2.4.1.310 | vancomycin aglycone glucosyltransferase | False | 1 | 75 | 0 | 1 | UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin | UDP-alpha-D-glucose:vancomycin aglycone 48-O-beta-glucosyltransferase | None | GtfB (ambiguous) | |
| 2.4.1.311 | chloroorienticin B synthase | False | 1 | 3 | 0 | 1 | dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B | dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase | None | GtfA | |
| 2.4.1.312 | protein O-mannose beta-1,4-N-acetylglucosaminyltransferase | False | 12 | 731 | 6 | 1 | UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase | None | GTDC2 (gene name); POMGNT2 | |
| 2.4.1.313 | protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase | False | 5 | 72 | 0 | 3 | UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase | None | B3GALNT2 | |
| 2.4.1.314 | ginsenoside Rd glucosyltransferase | True | 0 | 0 | 0 | 2 | UDP-alpha-D-glucose + ginsenoside Rd = UDP + ginsenoside Rb1 | UDP-glucose:ginsenoside-Rd beta-1,6-glucosyltransferase | None | UDPG:ginsenoside Rd glucosyltransferase; UDP-glucose:ginsenoside Rd glucosyltransferase; UGRdGT | |
| 2.4.2.55 | nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase | True | 0 | 0 | 0 | 1 | nicotinate D-ribonucleotide + phenol = nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside | nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase | None | ArsAB | |
| 2.4.2.56 | kaempferol 3-O-xylosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-xylose + kaempferol = UDP + kaempferol 3-O-beta-D-xyloside | UDP-alpha-D-xylose:kaempferol 3-O-D-xylosyltransferase | None | F3XT; UDP-D-xylose:flavonol 3-O-xylosyltransferase; flavonol 3-O-xylosyltransferase | |
| 2.5.1.112 | adenylate dimethylallyltransferase (ADP/ATP-dependent) | False | 8 | 8 | 0 | 5 | (1) prenyl diphosphate + ADP = diphosphate + N6-prenyladenosine 5'-diphosphate;;(2) prenyl diphosphate + ATP = diphosphate + N6-prenyladenosine 5'-triphosphate | prenyl-diphosphate:ADP/ATP prenyltransferase | None | cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Delta2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT; dimethylallyl-diphosphate:ADP/ATP dimethylallyltransferase | |
| 2.5.1.113 | [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase | False | 3 | 76 | 7 | 1 | O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + phosphate | O-phospho-L-serine:thiocarboxylated [CysO sulfur-carrier protein] 2-amino-2-carboxyethyltransferase | None | CysM | |
| 2.5.1.114 | tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase | False | 12 | 3493 | 0 | 4 | S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = S-methyl-5'-thioadenosine + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe | S-adenosyl-L-methionine:tRNAPhe (4-demethylwyosine37-C7)-[(3S)-3-amino-3-carboxypropyl]transferase | None | TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name) | |
| 2.6.1.103 | (S)-3,5-dihydroxyphenylglycine transaminase | False | 1 | 41 | 0 | 1 | (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate | (S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase | None | HpgT | |
| 2.8.3.19 | CoA:oxalate CoA-transferase | False | 2 | 1382 | 0 | 1 | acetyl-CoA + oxalate = acetate + oxalyl-CoA | acetyl-CoA:oxalate CoA-transferase | None | acetyl-coenzyme A transferase; acetyl-CoA oxalate CoA-transferase; ACOCT; YfdE; UctC | |
| 2.7.1.180 | FAD:protein FMN transferase | False | 14 | 37925 | 17 | 5 | FAD + [protein]-L-threonine = [protein]-FMN-L-threonine + AMP | FAD:protein riboflavin-5'-phosphate transferase | None | flavin transferase; apbE (gene name) | |
| 2.7.1.223 | aminoimidazole riboside kinase | False | 1 | 0 | 0 | 2 | ATP + 5-amino-1-(beta-D-ribosyl)imidazole = ADP + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole | ATP:5-amino-1-(beta-D-ribosyl)imidazole 5'-phosphotransferase | None | STM4066 (locus name) | |
| 3.2.1.187 | (Ara-f)3-Hyp beta-L-arabinobiosidase | False | 1 | 77 | 2 | 2 | 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose | 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose hydrolase | None | hypBA2 (gene name); beta-L-arabinobiosidase | |
| 3.2.1.188 | avenacosidase | False | 2 | 0 | 0 | 3 | avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose | avenacoside B 26-beta-D-glucohydrolase | None | As-P60 | |
| 3.2.1.189 | dioscin glycosidase (diosgenin-forming) | True | 0 | 0 | 0 | 2 | 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin + 3 H2O = D-glucose + 2 L-rhamnose + diosgenin | 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin hydrolase (diosgenin-forming) | None | dioscin glycosidase (aglycone-forming) | |
| 3.2.1.190 | dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming) | True | 0 | 0 | 0 | 1 | 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin + 2 H2O = 2 L-rhamnopyranose + diosgenin 3-O-beta-D-glucopyranoside | 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin (3-O-beta-D-Glc-diosgenin-forming) | None | dioscin-alpha-L-rhamnosidase | |
| 3.3.2.13 | chorismatase | False | 2 | 6 | 0 | 1 | chorismate + H2O = (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate | chorismate pyruvate-hydrolase | None | chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase; fkbO (gene name); rapK (gene name) | |
| 3.4.21.121 | Lys-Lys/Arg-Xaa endopeptidase | False | 1 | 0 | 0 | 1 | Cleavage of -Lys-Lys! and -Lys-Arg! bonds. | None | None | ASP (Aeromonas sobria)-type peptidase; Aeromonas extracellular serine protease | |
| 3.5.1.114 | N-acyl-aromatic-L-amino acid amidohydrolase | False | 14 | 600 | 0 | 3 | (1) an N-acyl-aromatic-L-amino acid + H2O = an aromatic-L-amino acid + a carboxylate;;(2) an N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | None | aminoacylase 3; aminoacylase III; ACY3 (gene name) | |
| 3.5.1.115 | mycothiol S-conjugate amidase | False | 4 | 4356 | 0 | 3 | a mycothiol S-conjugate + H2O = an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | mycothiol S-conjugate 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranosyl-hydrolase | None | MCA | |
| 3.5.3.26 | (S)-ureidoglycine aminohydrolase | False | 3 | 2030 | 0 | 2 | (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3 | (S)-ureidoglycine aminohydrolase | None | UGlyAH; UGHY; ylbA (gene name) | |
| 3.6.1.66 | XTP/dITP diphosphatase | False | 256 | 38302 | 1 | 7 | (1) XTP + H2O = XMP + diphosphate;;(2) dITP + H2O = dIMP + diphosphate;;(3) ITP + H2O = IMP + diphosphate | XTP/dITP diphosphohydrolase (diphosphate-forming) | None | hypoxanthine/xanthine dNTP pyrophosphatase; rdgB (gene name) | |
| 4.1.3.45 | 3-hydroxybenzoate synthase | False | 1 | 31 | 0 | 5 | chorismate = 3-hydroxybenzoate + pyruvate | chorismate pyruvate-lyase (3-hydroxybenzoate-forming) | None | chorismatase/3-hydroxybenzoate synthase; hyg5 (gene name); bra8 (gene name); XanB2 | |
| 5.1.3.27 | dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase | False | 2 | 9 | 0 | 1 | dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-gulose | dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3-epimerase | None | dTDP-deoxyglucose 3-epimerase; dTDP-4-keto-6-deoxy-D-glucose 3-epimerase; dTDP-4-keto-6-deoxyglucose 3-epimerase; gerF (gene name); tylJ (gene name); chmJ (gene name); mydH (gene name) | |
| 4.3.1.29 | D-glucosaminate-6-phosphate ammonia-lyase | False | 1 | 53 | 0 | 1 | 2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH3 | 2-amino-2-deoxy-D-gluconate 6-phosphate ammonia-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming) | None | DgaE; 6-phospho-D-glucosaminate ammonia-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming) | |
| 5.5.1.24 | tocopherol cyclase | False | 2 | 9 | 0 | 10 | (1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol ;; (2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol ;; (3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol ;; (4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol | delta/gamma-tocopherol lyase (ring-opening) | None | VTE1 (gene name); SXD1 (gene name); delta/gamma-tocopherol lyase (decyclizing) | |
| 1.1.1.367 | UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase | False | 1 | 108 | 0 | 2 | UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+ | UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase | None | WbjC; Cap5F | |
| 1.1.1.368 | 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase | False | 1 | 112 | 2 | 1 | 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ = 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ | 6-hydroxycyclohex-1-ene-1-carbonyl-CoA:NAD+ 6-oxidoreductase | None | None | |
| 1.1.1.369 | D-chiro-inositol 1-dehydrogenase | False | 7 | 976 | 0 | 2 | 1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ | 1D-chiro-inositol:NAD+ 1-oxidoreductase | None | DCI 1-dehydrogenase; IolG | |
| 1.1.1.370 | scyllo-inositol 2-dehydrogenase (NAD+) | False | 1 | 401 | 0 | 2 | scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | scyllo-inositol:NAD+ 2-oxidoreductase | None | iolX (gene name) | |
| 1.1.1.371 | scyllo-inositol 2-dehydrogenase (NADP+) | False | 2 | 246 | 0 | 1 | scyllo-inositol + NADP+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+ | scyllo-inositol:NADP+ 2-oxidoreductase | None | iolW (gene name) | |
| 1.1.5.10 | D-2-hydroxyacid dehydrogenase (quinone) | True | 0 | 0 | 0 | 3 | (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol | (R)-2-hydroxyacid:quinone oxidoreductase | None | (R)-2-hydroxy acid dehydrogenase; (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase; D-lactate dehydrogenase (ambiguous) | |
| 1.2.1.89 | D-glyceraldehyde dehydrogenase (NADP+) | False | 2 | 8 | 3 | 3 | D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+ | D-glyceraldehyde:NADP+ oxidoreductase | None | glyceraldehyde dehydrogenase; GADH | |
| 1.3.1.106 | cobalt-precorrin-6A reductase | False | 6 | 3421 | 0 | 2 | cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+ | cobalt-precorrin-6B:NAD+ oxidoreductase | None | cbiJ (gene name) | |
| 1.5.98.1 | methylenetetrahydromethanopterin dehydrogenase | False | 19 | 811 | 0 | 12 | 5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 | 5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase | None | N5,N10-methylenetetrahydromethanopterin dehydrogenase; 5,10-methylenetetrahydromethanopterin dehydrogenase | |
| 1.5.98.2 | 5,10-methylenetetrahydromethanopterin reductase | False | 9 | 1256 | 1 | 9 | 5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 | 5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase | None | 5,10-methylenetetrahydromethanopterin cyclohydrolase; N5,N10-methylenetetrahydromethanopterin reductase; methylene-H4MPT reductase; coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase; N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase | |
| 1.6.3.5 | renalase | False | 5 | 951 | 2 | 5 | (1) 1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2;;(2) 1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 | dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming) | None | alphaNAD(P)H oxidase/anomerase (incorrect); NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect) | |
| 1.14.13.187 | L-evernosamine nitrososynthase | False | 1 | 0 | 2 | 3 | dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O (overall reaction);;(1a) dTDP-beta-L-evernosamine + NADPH + H+ + O2 = dTDP-N-hydroxy-beta-L-evernosamine + NADP+ + H2O;;(1b) dTDP-N-hydroxy-beta-L-evernosamine + NADPH + H+ + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + NADP+ + 2 H2O | dTDP-beta-L-evernosamine,NADPH:oxygen oxidoreductase (N-hydroxylating) | None | None | |
| 1.16.1.10 | ferric-chelate reductase [NAD(P)H] | False | 2 | 3 | 0 | 5 | 2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H | Fe(II)-siderophore:NAD(P)+ oxidoreductase | None | ferric reductase (ambiguous) | |
| 2.1.1.294 | 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase | False | 2 | 17 | 0 | 3 | S-adenosyl-L-methionine + 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol = S-adenosyl-L-homocysteine + 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | S-adenosyl-L-methionine:3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase | None | WbdD; S-adenosyl-L-methionine:3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-alpha-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase | |
| 2.1.1.295 | 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase | False | 5 | 83 | 0 | 8 | (1) S-adenosyl-L-methionine + 2-methyl-6-phytylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytylbenzene-1,4-diol;;(2) S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol = S-adenosyl-L-homocysteine + plastoquinol;;(3) S-adenosyl-L-methionine + 6-geranylgeranyl-2-methylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol | S-adenosyl-L-methionine:2-methyl-6-phytyl-1,4-benzoquinol C-3-methyltransferase | None | VTE3 (gene name); 2-methyl-6-solanyl-1,4-hydroquinone methyltransferase; MPBQ/MSBQ methyltransferase; MPBQ/MSBQ MT | |
| 2.1.1.296 | methyltransferase cap2 | False | 5 | 1357 | 0 | 3 | S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] | S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase | None | CMTR2 (gene name); MTR2; cap2-MTase; mRNA (nucleoside-2'-O)-methyltransferase (ambiguous) | |
| 2.1.1.297 | peptide chain release factor N5-glutamine methyltransferase | False | 83 | 44877 | 0 | 5 | S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine | S-adenosyl-L-methionine:[peptide chain release factor 1 or 2]-L-glutamine (N5-glutamine)-methyltransferase | None | N5-glutamine S-adenosyl-L-methionine dependent methyltransferase; N5-glutamine MTase; HemK; PrmC | |
| 2.1.1.298 | ribosomal protein uL3 N5-glutamine methyltransferase | False | 22 | 7165 | 0 | 2 | S-adenosyl-L-methionine + [ribosomal protein uL3]-L-glutamine = S-adenosyl-L-homocysteine + [ribosomal protein uL3]-N5-methyl-L-glutamine | S-adenosyl-L-methionine:[ribosomal protein uL3]-L-glutamine (N5-glutamine)-methyltransferase | None | YfcB; PrmB | |
| 2.1.1.299 | protein N-terminal monomethyltransferase | False | 4 | 1 | 4 | 2 | S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein] | S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase | None | NRMT2 (gene name); METTL11B (gene name); N-terminal monomethylase | |
| 2.1.1.300 | pavine N-methyltransferase | False | 1 | 1 | 5 | 1 | S-adenosyl-L-methionine + (+/-)-pavine = S-adenosyl-L-homocysteine + N-methylpavine | S-adenosyl-L-methionine:(+/-)-pavine N-methyltransferase | None | PavNMT | |
| 2.3.1.232 | methanol O-anthraniloyltransferase | False | 1 | 17 | 0 | 1 | anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate | anthraniloyl-CoA:methanol O-anthraniloyltransferase | None | AMAT; anthraniloyl-coenzyme A (CoA):methanol acyltransferase | |
| 2.4.1.315 | diglucosyl diacylglycerol synthase (1,6-linking) | False | 38 | 543 | 0 | 3 | (1) UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol + UDP;;(2) UDP-alpha-D-glucose + 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol = 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl]-sn-glycerol + UDP | UDP-alpha-D-glucose:1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol 6-glucosyltransferase | None | monoglucosyl diacylglycerol (1->6) glucosyltransferase; MGlcDAG (1->6) glucosyltransferase; DGlcDAG synthase (ambiguous); UGT106B1; ypfP (gene name) | |
| 2.4.1.316 | tylactone mycaminosyltransferase | False | 1 | 4 | 0 | 1 | tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone | dTDP-alpha-D-mycaminose:tylactone 5-O-beta-D-mycaminosyltransferase | None | tylM2 (gene name) | |
| 2.4.1.317 | O-mycaminosyltylonolide 6-deoxyallosyltransferase | False | 1 | 46 | 0 | 1 | 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin | dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-alpha-D-allosyltransferase | None | tylN (gene name) | |
| 2.4.1.318 | demethyllactenocin mycarosyltransferase | False | 1 | 14 | 0 | 1 | dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin | dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase | None | tylCV (gene name); tylC5 (gene name) | |
| 2.4.1.319 | beta-1,4-mannooligosaccharide phosphorylase | False | 1 | 104 | 2 | 1 | [(1->4)-beta-D-mannosyl]n + phosphate = [(1->4)-beta-D-mannosyl]n-1 + alpha-D-mannose 1-phosphate | 1,4-beta-D-mannooligosaccharide:phosphate alpha-D-mannosyltransferase | None | RaMP2 | |
| 2.4.1.320 | 1,4-beta-mannosyl-N-acetylglucosamine phosphorylase | False | 1 | 70 | 0 | 1 | 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate | 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine:phosphate alpha-D-mannosyltransferase | None | BT1033 | |
| 2.4.1.321 | cellobionic acid phosphorylase | False | 2 | 14 | 4 | 3 | 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate | 4-O-beta-D-glucopyranosyl-D-gluconate:phosphate alpha-D-glucosyltransferase | None | None | |
| 2.4.1.322 | devancosaminyl-vancomycin vancosaminetransferase | False | 1 | 4 | 0 | 1 | dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin | dTDP-beta-L-vancomycin:devancosaminyl-vancomycin beta-L-vancosaminetransferase | None | devancosaminyl-vancomycin TDP-vancosaminyltransferase; GtfD; dTDP-beta-L-vancomycin:desvancosaminyl-vancomycin beta-L-vancosaminetransferase; desvancosaminyl-vancomycin vancosaminetransferase | |
| 2.4.1.323 | 7-deoxyloganetic acid glucosyltransferase | False | 2 | 9 | 0 | 1 | UDP-alpha-D-glucose + 7-deoxyloganetate = UDP + 7-deoxyloganate | UDP-alpha-D-glucose:7-deoxyloganetate O-D-glucosyltransferase | None | UGT8 | |
| 2.4.1.324 | 7-deoxyloganetin glucosyltransferase | False | 2 | 109 | 0 | 3 | UDP-alpha-D-glucose + 7-deoxyloganetin = UDP + 7-deoxyloganin | UDP-alpha-D-glucose:7-deoxyloganetin O-D-glucosyltransferase | None | UDPglucose:iridoid glucosyltransferase; UGT6; UGT85A24 | |
| 2.4.2.57 | AMP phosphorylase | False | 29 | 1199 | 0 | 1 | (1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate;;(2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate;;(3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate | AMP:phosphate alpha-D-ribosyl 5'-phosphate-transferase | None | AMPpase; nucleoside monophosphate phosphorylase; deoA (gene name) | |
| 2.4.99.20 | 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase | False | 7 | 658 | 0 | 6 | NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction);;(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide;;(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate | NADP+:nicotinate ADP-ribosyltransferase | None | diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name) | |
| 2.5.1.115 | homogentisate phytyltransferase | False | 4 | 382 | 0 | 10 | phytyl diphosphate + homogentisate = diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2 | phytyl-diphosphate:homogentisate phytyltransferase | None | HPT; VTE2 (gene name) | |
| 2.5.1.116 | homogentisate geranylgeranyltransferase | False | 3 | 10 | 0 | 6 | geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 | geranylgeranyl-diphosphate:homogentisate geranylgeranyltransferase | None | HGGT; slr1736 (gene name) | |
| 2.5.1.117 | homogentisate solanesyltransferase | False | 2 | 21 | 0 | 3 | all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 | all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase | None | HST; PDS2 (gene name) | |
| 2.5.1.118 | beta-(isoxazolin-5-on-2-yl)-L-alanine synthase | True | 0 | 0 | 0 | 2 | O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate | O-acetyl-L-serine:isoxazolin-5-one 2-(2-amino-2-carboxyethyl)transferase | None | None | |
| 2.5.1.119 | beta-(isoxazolin-5-on-4-yl)-L-alanine synthase | True | 0 | 0 | 0 | 1 | O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate | O-acetyl-L-serine:isoxazolin-5-one 4-(2-amino-2-carboxyethyl)transferase | None | None | |
| 2.5.1.120 | aminodeoxyfutalosine synthase | False | 2 | 5471 | 2 | 3 | S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + HCO3- | S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming) | None | MqnE; AFL synthase; aminofutalosine synthase; S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming) | |
| 2.6.1.104 | 3-dehydro-glucose-6-phosphate---glutamate transaminase | False | 1 | 11 | 0 | 1 | kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate | kanosamine 6-phosphate:2-oxoglutarate aminotransferase | None | 3-oxo-glucose-6-phosphate:glutamate aminotransferase; ntdA (gene name) | |
| 2.6.1.105 | lysine---8-amino-7-oxononanoate transaminase | False | 1 | 25 | 0 | 1 | L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate | L-lysine:8-amino-7-oxononanoate aminotransferase | None | DAPA aminotransferase (ambiguous); bioA (gene name) (ambiguous); bioK (gene name) | |
| 2.6.1.106 | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase | False | 2 | 136 | 0 | 1 | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase | None | desV (gene name); megDII (gene name); eryCI (gene name) | |
| 2.6.1.107 | beta-methylphenylalanine transaminase | False | 1 | 5 | 0 | 1 | (2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate | (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase | None | TyrB | |
| 2.7.1.181 | polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase | False | 2 | 17 | 0 | 1 | ATP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol = ADP + 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | ATP:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phosphotransferase | None | WbdD; ATP:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phosphotransferase | |
| 2.7.1.182 | phytol kinase | False | 9 | 1179 | 0 | 3 | CTP + phytol = CDP + phytyl phosphate | CTP:phytol O-phosphotransferase | None | VTE5 (gene name) | |
| 2.8.3.20 | succinyl-CoA---D-citramalate CoA-transferase | False | 1 | 44 | 0 | 1 | (1) succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA;; (2) succinyl-CoA + (R)-malate = succinate + (R)-malyl-CoA | succinyl-CoA:(R)-citramalate CoA-transferase | None | Sct | |
| 2.8.3.21 | L-carnitine CoA-transferase | False | 34 | 725 | 0 | 2 | (1) (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA;;(2) 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA | (E)-4-(trimethylammonio)but-2-enoyl-CoA:L-carnitine CoA-transferase | None | CaiB; crotonobetainyl/gamma-butyrobetainyl-CoA:carnitine CoA-transferase | |
| 2.8.3.22 | succinyl-CoA---L-malate CoA-transferase | False | 4 | 504 | 0 | 1 | (1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA;; (2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA | succinyl-CoA:(S)-malate CoA-transferase | None | SmtAB | |
| 2.8.4.3 | tRNA-2-methylthio-N6-dimethylallyladenosine synthase | False | 613 | 37378 | 5 | 2 | N6-(3-methylbut-2-en-1-yl)-adenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = N6-(3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenine + electron acceptor (overall reaction);;(1a) N6-(3-methylbut-2-en-1-yl)-adenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced electron acceptor = N6-(3-methylbut-2-en-1-yl)-2-thioadenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenine + electron acceptor ;;(1b) S-adenosyl-L-methionine + N6-(3-methylbut-2-en-1-yl)-2-thioadenine37 in tRNA = S-adenosyl-L-homocysteine + N6-(3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenine37 in tRNA | tRNA N6-(3-methylbut-2-en-1-yl)-adenine37:sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-(methylsulfanyl)transferase | None | MiaB; 2-methylthio-N-6-isopentenyl adenosine synthase; tRNA-i6A37 methylthiotransferase; tRNA (N6-dimethylallyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-methylthiotransferase | |
| 2.8.4.4 | [ribosomal protein uS12] (aspartate89-C3)-methylthiotransferase | False | 412 | 26131 | 0 | 3 | L-aspartate89-[ribosomal protein uS12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced acceptor = 3-(methylsulfanyl)-L-aspartate89-[ribosomal protein uS12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized acceptor (overall reaction);; (1a) S-adenosyl-L-methionine + L-aspartate89-[ribosomal protein uS12] + sulfur-(sulfur carrier) = S-adenosyl-L-homocysteine + L-aspartate89-[ribosomal protein uS12]-methanethiol + (sulfur carrier);; (1b) L-aspartate89-[ribosomal protein uS12]-methanethiol + S-adenosyl-L-methionine + reduced acceptor = 3-(methylsulfanyl)-L-aspartate89-[ribosomal protein uS12] + L-methionine + 5'-deoxyadenosine + oxidized acceptor | [ribosomal protein uS12]-L-aspartate89:sulfur-(sulfur carrier),S-adenosyl-L-methionine C3-(methylsulfanyl)transferase | None | RimO; [ribosomal protein S12]-Asp89:sulfur-(sulfur carrier),S-adenosyl-L-methionine C3-methylthiotransferase; [ribosomal protein S12]-L-aspartate89:sulfur-(sulfur carrier),S-adenosyl-L-methionine C3-methylthiotransferase | |
| 2.8.4.5 | tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase | False | 20 | 8734 | 0 | 1 | N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor (overall reaction);;(1a) N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced electron acceptor = 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor;;(1b) S-adenosyl-L-methionine + 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA = S-adenosyl-L-homocysteine + 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA | tRNA (N6-L-threonylcarbamoyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-(methylsulfanyl)transferase | None | MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name); tRNA (N6-L-threonylcarbamoyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-methylthiotransferase | |
| 3.1.2.30 | (3S)-malyl-CoA thioesterase | False | 8 | 185 | 0 | 1 | (S)-malyl-CoA + H2O = (S)-malate + CoA | (S)-malyl-CoA hydrolase | None | mcl2 (gene name) | |
| 3.1.3.93 | L-galactose 1-phosphate phosphatase | False | 2 | 12 | 0 | 5 | beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate | beta-L-galactose-1-phosphate phosphohydrolase | None | VTC4 (gene name) (ambiguous); IMPL2 (gene name) (ambiguous) | |
| 3.1.3.94 | D-galactose 1-phosphate phosphatase | False | 9 | 49 | 0 | 3 | alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate | alpha-D-galactose-1-phosphate phosphohydrolase | None | None | |
| 3.1.3.95 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase | False | 28 | 5074 | 1 | 2 | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase | None | MTMR; PtdIns-3,5-P2 3-Ptase | |
| 3.1.21.8 | T4 deoxyribonuclease II | False | 1 | 33 | 0 | 1 | Endonucleolytic nicking and cleavage of cytosine-containing double-stranded DNA. | None | None | T4 endonuclease II; EndoII (ambiguous); denA (gene name) | |
| 3.1.21.9 | T4 deoxyribonuclease IV | False | 1 | 16 | 0 | 1 | Endonucleolytic cleavage of the 5' phosphodiester bond of deoxycytidine in single-stranded DNA. | None | None | T4 endonuclease IV; EndoIV (ambiguous); denB (gene name) | |
| 3.2.1.191 | ginsenosidase type III | True | 0 | 0 | 0 | 12 | a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + 2 H2O = a protopanaxadiol-type ginsenoside with no glycosidic modification at position 3 + 2 D-glucopyranose (overall reaction);;(1a) a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + H2O = a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + D-glucopyranose;;(1b) a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + H2O = a protopanaxadiol-type ginsenoside with no glycosidic modification at position 3 + D-glucopyranose | protopanaxadiol-type ginsenoside 3-beta-D-hydrolase | None | None | |
| 3.2.1.192 | ginsenoside Rb1 beta-glucosidase | True | 0 | 0 | 0 | 10 | ginsenoside Rb1 + 2 H2O = ginsenoside Rg3 + 2 D-glucopyranose (overall reaction);;(1a) ginsenoside Rb1 + H2O = ginsenoside Rd + D-glucopyranose;;(1b) ginsenoside Rd + H2O = ginsenoside Rg3 + D-glucopyranose | ginsenoside Rb1 glucohydrolase | None | None | |
| 3.2.1.193 | ginsenosidase type I | True | 0 | 0 | 0 | 27 | (1) a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + H2O = a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + D-glucopyranose;; (2) a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + H2O = a protopanaxadiol-type ginsenoside with no glycosidic modifications at position 3 + D-glucopyranose;;(3) a protopanaxadiol-type ginsenoside with two glycosyl residues at position 20 + H2O = a protopanaxadiol-type ginsenoside with a single glucosyl residue at position 20 + a monosaccharide | ginsenoside glucohydrolase | None | None | |
| 3.2.1.194 | ginsenosidase type IV | True | 0 | 0 | 0 | 13 | a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + 2 H2O = a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + D-glucopyranose + a monosaccharide (overall reaction);;(1a) a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + H2O = a protopanaxatriol-type ginsenoside with a single glucosyl at position 6 + a monosaccharide;;(1b) a protopanaxatriol-type ginsenoside with a single glucosyl at position 6 + H2O = a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + D-glucopyranose | protopanaxatriol-type ginsenoside 6-beta-D-glucohydrolase | None | None | |
| 3.2.1.195 | 20-O-multi-glycoside ginsenosidase | True | 0 | 0 | 0 | 4 | a protopanaxadiol-type ginsenoside with two glycosyl residues at position 20 + H2O = a protopanaxadiol-type ginsenoside with a single glucosyl residue at position 20 + a monosaccharide | protopanaxadiol-type ginsenoside 20-beta-D-glucohydrolase | None | ginsenosidase type II (erroneous) | |
| 3.2.2.30 | aminodeoxyfutalosine nucleosidase | False | 3 | 12 | 8 | 6 | 6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine | 6-amino-6-deoxyfutalosine ribohydrolase | None | AFL nucleosidase; aminofutalosine nucleosidase; methylthioadenosine nucleosidase; MqnB (ambiguous) | |
| 3.5.1.116 | ureidoglycolate amidohydrolase | False | 2 | 472 | 0 | 4 | (S)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2 | (S)-ureidoglycolate amidohydrolase (decarboxylating) | None | ureidoglycolate hydrolase; UAH (gene name) | |
| 3.5.4.40 | aminodeoxyfutalosine deaminase | False | 5 | 180 | 0 | 5 | 6-amino-6-deoxyfutalosine + H2O = futalosine + NH3 | 6-amino-6-deoxyfutalosine deaminase | None | AFL deaminase; aminofutalosine deaminase; mqnX (gene name) | |
| 3.5.99.10 | 2-iminobutanoate/2-iminopropanoate deaminase | False | 13 | 1550 | 3 | 10 | (1) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3;;(2) 2-iminopropanoate + H2O = pyruvate + NH3 | 2-iminobutanoate aminohydrolase | None | yjgF (gene name); ridA (gene name); enamine/imine deaminase (ambiguous) | |
| 3.7.1.21 | 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase | False | 3 | 702 | 0 | 11 | 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxypimeloyl-CoA (overall reaction);;(1a) 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA;;(1b) 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxypimeloyl-CoA | 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (ring-opening) | None | 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (decyclizing) | |
| 3.7.1.22 | 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening) | False | 25 | 4215 | 0 | 2 | 3D-3,5/4-trihydroxycyclohexa-1,2-dione + H2O = 5-deoxy-D-glucuronate | 3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (ring-opening) | None | IolD; THcHDO hydrolase; 3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (decyclizing); 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing) | |
| 4.1.1.97 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | False | 11 | 10717 | 5 | 4 | 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO2 | 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate carboxy-lyase [(S)-allantoin-forming] | None | OHCU decarboxylase; hpxQ (gene name); PRHOXNB (gene name) | |
| 4.1.2.55 | 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase | False | 4 | 6 | 8 | 4 | (1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate;;(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate | 2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming) | None | 2-keto-3-deoxygluconate aldolase (ambiguous); KDGA (ambiguous) | |
| 4.1.2.56 | 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase | False | 2 | 48 | 0 | 1 | 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = glycerone phosphate + L-aspartate 4-semialdehyde | 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate L-aspartate 4-semialdehyde-lyase (glycerone phosphate-forming) | None | griI (gene name) | |
| 4.1.3.46 | (R)-citramalyl-CoA lyase | False | 1 | 29 | 0 | 2 | (3R)-citramalyl-CoA = acetyl-CoA + pyruvate | (3R)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming) | None | Ccl | |
| 4.2.1.147 | 5,6,7,8-tetrahydromethanopterin hydro-lyase | False | 16 | 776 | 0 | 1 | 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O | 5,6,7,8-tetrahydromethanopterin hydro-lyase (formaldehyde-adding, tetrahydromethanopterin-forming) | None | formaldehyde-activating enzyme | |
| 4.2.1.148 | 2-methylfumaryl-CoA hydratase | False | 4 | 209 | 0 | 3 | (2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O | (2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming) | None | Mcd; erythro-beta-methylmalonyl-CoA hydrolyase; mesaconyl-coenzyme A hydratase (ambiguous); mesaconyl-C1-CoA hydratase | |
| 4.2.1.149 | crotonobetainyl-CoA hydratase | False | 25 | 1846 | 0 | 2 | L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O | L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] | None | CaiD; L-carnityl-CoA dehydratase | |
| 4.2.1.150 | short-chain-enoyl-CoA hydratase | False | 4 | 1117 | 1 | 6 | a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain trans-2-enoyl-CoA + H2O | short-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase | None | 3-hydroxybutyryl-CoA dehydratase; crotonase; crt (gene name) | |
| 4.2.1.151 | chorismate dehydratase | False | 3 | 6873 | 8 | 3 | chorismate = 3-[(1-carboxyvinyl)oxy]benzoate + H2O | chorismate hydro-lyase (3-[(1-carboxyvinyl)oxy]benzoate-forming) | None | MqnA | |
| 4.3.1.30 | dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase | False | 1 | 41 | 0 | 1 | dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor | dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose ammonia lyase (dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose-forming) | None | desII (gene name); eryCV (gene name); MegCV | |
| 4.6.1.16 | tRNA-intron lyase | False | 57 | 9649 | 7 | 20 | pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus | pretRNA lyase (intron-removing; cyclic-2',3'-phosphate-forming) | None | transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease | |
| 5.1.3.28 | UDP-N-acetyl-L-fucosamine synthase | False | 0 | 8 | 0 | 2 | UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine | UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase | None | WbjD; Cap5G | |
| 5.3.1.30 | 5-deoxy-glucuronate isomerase | False | 14 | 3990 | 0 | 1 | 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate | 5-deoxy-D-glucuronate aldose-ketose-isomerase | None | 5DG isomerase; IolB | |
| 5.3.99.11 | 2-keto-myo-inositol isomerase | False | 4 | 242 | 0 | 1 | 2,4,6/3,5-pentahydroxycyclohexanone = 2D-2,3,5/4,6-pentahydroxycyclohexanone | 2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase | None | IolI; inosose isomerase; 2KMI isomerase. | |
| 5.4.1.3 | 2-methylfumaryl-CoA isomerase | False | 1 | 123 | 2 | 1 | 2-methylfumaryl-CoA = 3-methylfumaryl-CoA | 2-methylfumaryl-CoA 1,4-CoA-mutase | None | mesaconyl-CoA C1-C4 CoA transferase; Mct | |
| 5.4.99.60 | cobalt-precorrin-8 methylmutase | False | 7 | 1048 | 0 | 3 | cobalt-precorrin-8 = cobyrinate | precorrin-8 11,12-methylmutase | None | cbiC (gene name) | |
| 5.4.99.61 | precorrin-8X methylmutase | False | 5 | 5009 | 0 | 3 | precorrin-8X = hydrogenobyrinate | precorrin-8X 11,12-methylmutase | None | precorrin isomerase; hydrogenobyrinic acid-binding protein; cobH (gene name) | |
| 6.2.1.40 | 4-hydroxybutyrate---CoA ligase (AMP-forming) | False | 2 | 52 | 2 | 2 | ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA | 4-hydroxybutanoate:CoA ligase (AMP-forming) | None | 4-hydroxybutyrate-CoA synthetase (ambiguous); 4-hydroxybutyrate:CoA ligase (ambiguous); hbs (gene name); 4-hydroxybutyrate---CoA ligase | |
| 6.3.1.17 | beta-citrylglutamate synthase | False | 4 | 2 | 0 | 1 | ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate | citrate:L-glutamate ligase (ADP-forming) | None | NAAG synthetase I; NAAGS-I; RIMKLB (gene name) (ambiguous) | |
| 6.3.2.41 | N-acetylaspartylglutamate synthase | False | 6 | 1103 | 0 | 2 | ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate | N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming) | None | N-acetylaspartylglutamate synthetase; NAAG synthetase; NAAGS; RIMKLA (gene name) (ambiguous); RIMKLB (gene name) (ambiguous) | |
| 6.3.2.42 | N-acetylaspartylglutamylglutamate synthase | False | 2 | 0 | 0 | 1 | 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate | N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming) | None | N-acetylaspartylglutamylglutamate synthetase; NAAG(2) synthase; NAAG synthetase II; NAAGS-II; RIMKLA (gene name) (ambiguous) | |
| 1.1.1.374 | UDP-N-acetylglucosamine 3-dehydrogenase | False | 2 | 61 | 0 | 1 | UDP-N-acetyl-alpha-D-glucosamine + NAD+ = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+ | UDP-N-acetyl-alpha-D-glucosamine:NAD+ 3-oxidoreductase | None | None | |
| 1.1.1.372 | D/L-glyceraldehyde reductase | False | 14 | 268 | 0 | 2 | (1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+;; (2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ | glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming) | None | gld1 (gene name); gaaD (gene name) | |
| 1.1.1.373 | sulfolactaldehyde 3-reductase | False | 3 | 854 | 3 | 1 | (2S)-2,3-dihydroxypropane-1-sulfonate + NAD+ = (2S)-3-sulfolactaldehyde + NADH + H+ | (2S)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase | None | yihU (gene name) | |
| 1.1.3.46 | 4-hydroxymandelate oxidase | False | 1 | 151 | 41 | 3 | (S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 | (S)-4-hydroxymandelate:oxygen 1-oxidoreductase | None | 4HmO; HmO | |
| 1.3.99.36 | cypemycin cysteine dehydrogenase (decarboxylating) | False | 1 | 2 | 1 | 2 | cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor = C3.19,S21-cyclocypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + H2S + reduced acceptor | cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys:acceptor oxidoreductase (decarboxylating, cyclizing) | None | cypemycin decarboxylase; CypD | |
| 1.5.1.48 | 2-methyl-1-pyrroline reductase | False | 0 | 0 | 7 | 2 | (R)-2-methylpyrrolidine + NADP+ = 2-methyl-1-pyrroline + NADPH + H+ | (R)-2-methylpyrrolidine:NADP+ 2-oxidoreductase | None | (R)-imine reductase (ambiguous) | |
| 1.10.3.15 | grixazone synthase | False | 1 | 3 | 0 | 1 | 2 3-amino-4-hydroxybenzoate + N-acetyl-L-cysteine + 2 O2 = grixazone B + 4 H2O + CO2 | 3-amino-4-hydroxybenzoate:N-acetyl-L-cysteine:oxygen oxidoreductase | None | GriF | |
| 1.11.1.23 | (S)-2-hydroxypropylphosphonic acid epoxidase | False | 2 | 23 | 4 | 5 | (S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O | (S)-2-hydroxypropylphosphonate:hydrogen-peroxide epoxidase | None | HPP epoxidase; HppE; 2-hydroxypropylphosphonic acid epoxidase; Fom4; (S)-2-hydroxypropylphosphonate epoxidase | |
| 1.11.2.5 | 3-methyl-L-tyrosine peroxygenase | False | 1 | 2 | 4 | 1 | 3-methyl-L-tyrosine + H2O2 = 3-hydroxy-5-methyl-L-tyrosine + H2O | 3-methyl-L-tyrosine:hydrogen-peroxide oxidoreductase (3-hydroxy-5-methyl-L-tyrosine-forming) | None | SfmD; SacD; 3-methyltyrosine peroxidase; 3-methyl-L-tyrosine peroxidase | |
| 1.13.11.78 | 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) | False | 1 | 48 | 0 | 2 | (2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate | 2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming) | None | phnZ (gene name) | |
| 1.13.11.79 | aerobic 5,6-dimethylbenzimidazole synthase | False | 4 | 3039 | 0 | 5 | FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + other product(s) | FMNH2 oxidoreductase (5,6-dimethylbenzimidazole-forming) | None | BluB; flavin destructase | |
| 1.14.11.45 | L-isoleucine 4-hydroxylase | False | 1 | 22 | 1 | 1 | L-isoleucine + 2-oxoglutarate + O2 = (4S)-4-hydroxy-L-isoleucine + succinate + CO2 | L-isoleucine,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) | None | ido (gene name) | |
| 1.14.11.46 | 2-aminoethylphosphonate dioxygenase | False | 1 | 7 | 0 | 1 | (2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 | (2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating) | None | phnY (gene name) | |
| 1.14.13.189 | 5-methyl-1-naphthoate 3-hydroxylase | False | 1 | 5 | 0 | 1 | 5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O | 5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating) | None | AziB1 | |
| 1.14.14.15 | (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase | False | 1 | 0 | 0 | 1 | (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FAD + H2O | (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2],FADH2:oxygen oxidoreductase (5-hydroxylating) | None | SgcC | |
| 1.14.16.7 | phenylalanine 3-monooxygenase | False | 1 | 2 | 0 | 1 | L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = 3-hydroxy-L-phenylalanine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | L-phenylalanine,tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating) | None | PacX; phenylalanine 3-hydroxylase | |
| 1.16.3.2 | bacterial non-heme ferritin | False | 23 | 10849 | 48 | 7 | 4 Fe(II) + O2 + 6 H2O = 4 [FeO(OH)] + 8 H+ (overall reaction);;(1a) 2 Fe(II) + O2 + 4 H2O = 2 [FeO(OH)] + 4 H+ + H2O2;;(1b) 2 Fe(II) + H2O2 + 2 H2O = 2 [FeO(OH)] + 4 H+ | Fe(II):oxygen oxidoreductase ([FeO(OH)]core-producing) | None | FtnA; HuHF | |
| 2.1.1.301 | cypemycin N-terminal methyltransferase | False | 1 | 19 | 1 | 1 | 2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin] | S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase | None | CypM | |
| 2.1.1.302 | 3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase | False | 1 | 67 | 0 | 1 | S-adenosyl-L-methionine + 3-hydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 3-methoxy-5-methyl-1-naphthoate | S-adenosyl-L-methionine:3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase | None | AziB2 | |
| 2.1.1.303 | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | False | 1 | 8 | 0 | 1 | S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate | S-adenosyl-L-methionine:2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | None | NcsB1; neocarzinostatin O-methyltransferase | |
| 2.1.1.304 | L-tyrosine C3-methyltransferase | False | 1 | 15 | 0 | 2 | S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine | S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase | None | SfmM2; SacF | |
| 2.1.1.305 | 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase | False | 1 | 15 | 0 | 1 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C | S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase | None | ElmMI | |
| 2.1.1.306 | 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase | False | 1 | 2 | 0 | 1 | S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C | S-adenosyl-L-methionine:8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase | None | ElmMII | |
| 2.1.1.307 | 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase | False | 1 | 31 | 0 | 1 | S-adenosyl-L-methionine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C | S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase | None | ElmMIII | |
| 2.3.1.233 | 1,3,6,8-tetrahydroxynaphthalene synthase | False | 3 | 64 | 0 | 7 | 5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O | malonyl-CoA C-acyl transferase (1,3,6,8-tetrahydroxynaphthalene-forming) | None | PKS1; THNS; SCO1206; RppA | |
| 2.4.1.325 | TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase | False | 58 | 1562 | 0 | 1 | dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | dTDP-N-acetyl-alpha-D-fucose:N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol N-acetylfucosaminyltransferase | None | TDP-Fuc4NAc:lipid II Fuc4NAc-transferase; TDP-Fuc4NAc:lipid II Fuc4NAc transferase; wecF (gene name) | |
| 2.4.1.326 | aklavinone 7-L-rhodosaminyltransferase | False | 1 | 1 | 0 | 1 | dTDP-beta-L-rhodosamine + aklavinone = dTDP + aclacinomycin T | dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase (configuration-inverting) | None | AknS/AknT; aklavinone 7-beta-L-rhodosaminyltransferase; dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase | |
| 2.4.1.327 | aclacinomycin-T 2-deoxy-L-fucose transferase | False | 1 | 7 | 0 | 1 | dTDP-2-deoxy-beta-L-fucose + aclacinomycin T = dTDP + aclacinomycin S | dTDP-2-deoxy-beta-L-fucose:7-(alpha-L-rhodosaminyl)aklavinone 2-deoxy-alpha-L-fucosyltransferase | None | AknK | |
| 2.4.1.328 | erythronolide mycarosyltransferase | False | 1 | 0 | 0 | 2 | dTDP-beta-L-mycarose + erythronolide B = dTDP + 3-alpha-L-mycarosylerythronolide B | dTDP-beta-L-mycarose:erythronolide B L-mycarosyltransferase | None | EryBV | |
| 2.5.1.121 | 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase | False | 1 | 5 | 0 | 1 | prenyl diphosphate + 5,10-dihydrophenazine-1-carboxylate = diphosphate + 9-prenyl-5,10-dihydrophenazine-1-carboxylate | prenyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-prenyltransferase | None | PpzP; dihydrophenazine-1-carboxylate dimethylallyltransferase; 5,10-dihydrophenazine 1-carboxylate dimethylallyltransferase; dimethylallyl diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase | |
| 2.5.1.122 | 4-O-dimethylallyl-L-tyrosine synthase | False | 2 | 0 | 0 | 3 | prenyl diphosphate + L-tyrosine = diphosphate + 4-O-prenyl-L-tyrosine | prenyl-diphosphate:L-tyrosine 4-O-prenyltransferase | None | SirD; dimethylallyl diphosphate:L-tyrosine 4-O-dimethylallyltransferase | |
| 2.5.1.123 | flaviolin linalyltransferase | False | 1 | 2 | 0 | 1 | geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate | geranyl-diphosphate:flaviolin 3-linalyltransferase | None | Fnq26 | |
| 2.7.1.183 | glycoprotein-mannosyl O6-kinase | False | 7 | 780 | 1 | 3 | ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein] | ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase | None | SGK196; protein O-mannose kinase | |
| 2.7.1.184 | sulfofructose kinase | False | 2 | 967 | 3 | 1 | ATP + 6-deoxy-6-sulfo-D-fructose = ADP + 6-deoxy-6-sulfo-D-fructose 1-phosphate | ATP:6-deoxy-6-sulfo-D-fructose 1-phosphotransferase | None | yihV (gene name) | |
| 2.8.2.37 | trehalose 2-sulfotransferase | False | 3 | 15 | 0 | 2 | 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = adenosine 3',5'-bisphosphate + 2-O-sulfo-alpha,alpha-trehalose | 3'-phosphoadenylyl-sulfate:alpha,alpha-trehalose 2-sulfonotransferase | None | Stf0 sulfotransferase; 3'-phosphoadenylyl-sulfate:alpha,alpha-trehalose 2-sulfotransferase | |
| 3.1.1.96 | D-aminoacyl-tRNA deacylase | False | 600 | 36785 | 0 | 13 | (1) a D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA;;(2) glycyl-tRNAAla + H2O = glycine + tRNAAla | D-aminoacyl-tRNA aminoacylhydrolase | None | Dtd2; D-Tyr-tRNA(Tyr) deacylase; D-Tyr-tRNATyr deacylase; D-tyrosyl-tRNATyr aminoacylhydrolase; dtdA (gene name) | |
| 3.1.4.57 | phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase | False | 1 | 44 | 0 | 1 | (1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate;;(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate | 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase | None | cyclic phosphate dihydrolase; phnPP (gene name) | |
| 3.1.12.1 | 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming) | False | 12 | 7555 | 4 | 8 | exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates | None | None | Cas4; 5' to 3' single stranded DNA exonuclease | |
| 3.5.1.117 | 6-aminohexanoate-oligomer endohydrolase | False | 3 | 0 | 3 | 7 | [N-(6-aminohexanoyl)]n + H2O = [N-(6-aminohexanoyl)]n-x + [N-(6-aminohexanoyl)]x | 6-aminohexanoate oligomer endoamidohydrolase | None | endo-type 6-aminohexanoate oligomer hydrolase; Ahx endo-type-oligomer hydrolase; 6-aminohexanoate oligomer hydrolase; Ahx-oligomer hydrolase; nylon hydrolase; nylon-oligomer hydrolase; NylC; nylon-6 hydrolase (ambiguous) | |
| 3.13.1.4 | 3-sulfinopropanoyl-CoA desulfinase | False | 4 | 1 | 2 | 4 | 3-sulfinopropanoyl-CoA + H2O = propanoyl-CoA + sulfite | 3-sulfinopropanoyl-CoA sulfinohydrolase | None | 3SP-CoA desulfinase; AcdDPN7; 3-sulfinopropionyl-CoA desulfinase | |
| 4.1.1.98 | 4-hydroxy-3-polyprenylbenzoate decarboxylase | False | 145 | 5747 | 4 | 5 | a 4-hydroxy-3-polyprenylbenzoate = a 2-polyprenylphenol + CO2 | 4-hydroxy-3-polyprenylbenzoate carboxy-lyase | None | ubiD (gene name); 4-hydroxy-3-solanesylbenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate decarboxylase | |
| 4.1.2.57 | sulfofructosephosphate aldolase | False | 6 | 740 | 3 | 1 | 6-deoxy-6-sulfo-D-fructose 1-phosphate = glycerone phosphate + (2S)-3-sulfolactaldehyde | 6-deoxy-6-sulfofructose-1-phosphate (2S)-3-sulfolactaldehyde-lyase (glycerone-phosphate-forming) | None | yihT (gene name) | |
| 4.2.1.153 | 3-methylfumaryl-CoA hydratase | False | 1 | 273 | 0 | 2 | (S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O | (S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming) | None | Meh; mesaconyl-C4-CoA hydratase; mesaconyl-coenzyme A hydratase (ambiguous) | |
| 4.2.1.154 | tetracenomycin F2 cyclase | False | 1 | 9 | 0 | 1 | tetracenomycin F2 = tetracenomycin F1 + H2O | tetracenomycin F2 hydro-lyase (tetracenomycin-F1-forming) | None | tcmI (gene name) | |
| 4.2.3.145 | ophiobolin F synthase | False | 4 | 1 | 0 | 1 | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate | (2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, ophiobolin-F-forming) | None | None | |
| 4.2.3.146 | cyclooctat-9-en-7-ol synthase | False | 1 | 0 | 12 | 2 | geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclooctat-9-en-7-ol-forming) | None | cotB2 | |
| 5.1.3.29 | L-fucose mutarotase | False | 60 | 2099 | 0 | 4 | alpha-L-fucopyranose = beta-L-fucopyranose | L-fucose 1-epimerase | None | FucU; fucose mutarotase; FucM | |
| 5.3.1.31 | sulfoquinovose isomerase | False | 6 | 793 | 1 | 1 | (1) beta-sulfoquinovose = 6-deoxy-6-sulfo-D-fructose;;(2) beta-sulfoquinovose = 6-sulfo-D-rhamnose | 6-deoxy-6-sulfo-beta-D-glucopyranose aldose-ketose-isomerase | None | yihS (gene name) | |
| 5.4.4.7 | hydroperoxy icosatetraenoate isomerase | False | 4 | 0 | 0 | 2 | a hydroperoxyicosatetraenoate = a hydroxyepoxyicosatrienoate | hydroperoxyicosatetraenoate hydroxymutase | None | epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous) | |
| 6.1.2.2 | nebramycin 5' synthase | False | 1 | 52 | 0 | 1 | (1) tobramycin + carbamoyl phosphate + ATP + H2O = nebramycin 5' + AMP + diphosphate + phosphate (overall reaction);;(1a) carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate;;(1b) O-carbamoyladenylate + tobramycin = AMP + nebramycin 5' ;;(2) kanamycin A + carbamoyl phosphate + ATP + H2O = 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate (overall reaction);;(2a) carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate;;(2b) O-carbamoyladenylate + kanamycin A = AMP + 6''-O-carbamoylkanamycin A | tobramycin:carbamoyl phosphate ligase (AMP,phosphate-forming) | None | tobramycin carbamoyltransferase; TobZ | |
| 6.2.1.41 | 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase | False | 3 | 382 | 0 | 1 | ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA | 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate:CoA ligase (AMP-forming) | None | fadD3 (gene name); HIP---CoA ligase | |
| 6.2.1.42 | 3-oxocholest-4-en-26-oate---CoA ligase | False | 6 | 51 | 0 | 3 | ATP + (25S)-3-oxocholest-4-en-26-oate + CoA = AMP + diphosphate + (25S)-3-oxocholest-4-en-26-oyl-CoA | (25S)-3-oxocholest-4-en-26-oate:CoA ligase (AMP-forming) | None | fadD19 (gene name) | |
| 6.2.1.43 | 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase | False | 1 | 3 | 0 | 1 | ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA | 2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase | None | NcsB2 | |
| 6.3.1.18 | gamma-glutamylanilide synthase | False | 1 | 9 | 0 | 1 | ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine | L-glutamate:aniline ligase (ADP-forming) | None | atdA1 (gene name); tdnQ (gene name); dcaQ (gene name) | |
| 1.1.1.375 | L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] | False | 1 | 3 | 0 | 2 | a (2S)-2-hydroxycarboxylate + NAD(P)+ = a 2-oxocarboxylate + NAD(P)H + H+ | (2S)-2-hydroxycarboxylate:NAD(P)+ oxidoreductase | None | MdhII; lactate/malate dehydrogenase | |
| 1.1.1.376 | L-arabinose 1-dehydrogenase [NAD(P)+] | False | 2 | 95 | 4 | 3 | alpha-L-arabinopyranose + NAD(P)+ = L-arabinono-1,4-lactone + NAD(P)H + H+ | alpha-L-arabinopyranose:NAD(P)+ 1-oxidoreductase | None | L-arabino-aldose dehydrogenase | |
| 1.1.1.377 | L-rhamnose 1-dehydrogenase (NADP+) | False | 1 | 96 | 0 | 1 | L-rhamnose + NADP+ = L-rhamnono-1,4-lactone + NADPH + H+ | L-rhamnose:NADP+ 1-oxidoreductase | None | None | |
| 1.1.1.378 | L-rhamnose 1-dehydrogenase [NAD(P)+] | False | 0 | 31 | 0 | 2 | L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+ | L-rhamnose:NAD(P)+ 1-oxidoreductase | None | None | |
| 1.3.1.107 | sanguinarine reductase | False | 1 | 0 | 0 | 1 | (1) dihydrosanguinarine + NAD(P)+ = sanguinarine + NAD(P)H + H+;;(2) dihydrochelirubine + NAD(P)+ = chelirubine + NAD(P)H + H+ | dihydrosanguinarine:NAD(P)+ oxidoreductase | None | None | |
| 1.3.4.1 | fumarate reductase (CoM/CoB) | False | 2 | 56 | 0 | 1 | fumarate + CoM + CoB = succinate + CoM-S-S-CoB | fumarate CoM:CoB oxidoreductase (succinate-forming) | None | thiol:fumarate reductase; Tfr | |
| 1.5.99.15 | dihydromethanopterin reductase (acceptor) | False | 2 | 144 | 0 | 3 | 5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor | 5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase | None | DmrX | |
| 1.8.98.3 | sulfite reductase (coenzyme F420) | False | 1 | 18 | 2 | 1 | hydrogen sulfide + 3 oxidized coenzyme F420 + 3 H2O = sulfite + 3 reduced coenzyme F420 | hydrogen sulfide:coenzyme F420 oxidoreductase | None | coenzyme F420-dependent sulfite reductase; Fsr | |
| 1.14.11.47 | [50S ribosomal protein L16]-arginine 3-hydroxylase | False | 1 | 374 | 8 | 1 | [50S ribosomal protein L16]-L-Arg81 + 2-oxoglutarate + O2 = [50S ribosomal protein L16]-(3R)-3-hydroxy-L-Arg81 + succinate + CO2 | [50S ribosomal protein L16]-L-Arg81,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating) | None | ycfD (gene name) | |
| 1.14.13.195 | L-ornithine N5-monooxygenase (NADPH) | False | 2 | 74 | 0 | 10 | L-ornithine + NADPH + H+ + O2 = N5-hydroxy-L-ornithine + NADP+ + H2O | L-ornithine,NADPH:oxygen oxidoreductase (N5-hydroxylating) | None | CchB; ornithine hydroxylase; EtcB; PvdA; Af-OMO; dffA (gene name) | |
| 1.14.13.196 | L-ornithine N5-monooxygenase [NAD(P)H] | False | 12 | 2427 | 7 | 2 | L-ornithine + NAD(P)H + H+ + O2 = N5-hydroxy-L-ornithine + NAD(P)+ + H2O | L-ornithine,NAD(P)H:oxygen oxidoreductase (N5-hydroxylating) | None | SidA (ambiguous) | |
| 1.14.13.200 | tetracenomycin A2 monooxygenase-dioxygenase | False | 2 | 6 | 0 | 2 | tetracenomycin A2 + 2 O2 + 2 NADPH + 2 H+ = tetracenomycin C + 2 NADP+ + H2O | tetracenomycin A2,NADPH:oxygen oxidoreductase (tetracenomycin-C-forming) | None | TcmG; ElmG; tetracenomycin A2,NAD(P)H:O2 oxidoreductase (tetracenomycin C forming) | |
| 1.14.19.9 | tryptophan 7-halogenase | False | 3 | 545 | 6 | 3 | L-tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-L-tryptophan + FAD + 2 H2O | L-tryptophan:FADH2 oxidoreductase (7-halogenating) | None | prnA (gene name); rebH (gene name); ktzQ (gene name) | |
| 2.4.1.329 | sucrose 6F-phosphate phosphorylase | False | 2 | 282 | 1 | 2 | sucrose 6F-phosphate + phosphate = alpha-D-glucopyranose 1-phosphate + beta-D-fructofuranose 6-phosphate | sucrose 6F-phosphate:phosphate 1-alpha-D-glucosyltransferase | None | sucrose 6'-phosphate phosphorylase | |
| 2.4.1.330 | beta-D-glucosyl crocetin beta-1,6-glucosyltransferase | False | 1 | 0 | 0 | 1 | (1) UDP-alpha-D-glucose + beta-D-glucosyl crocetin = UDP + beta-D-gentiobiosyl crocetin;;(2) UDP-alpha-D-glucose + bis(beta-D-glucosyl) crocetin = UDP + beta-D-gentiobiosyl beta-D-glucosyl crocetin;;(3) UDP-alpha-D-glucose + beta-D-gentiobiosyl beta-D-glucosyl crocetin = UDP + crocin | UDP-alpha-D-glucose:beta-D-glucosyl crocetin beta-1,6-glucosyltransferase | None | UGT94E5; UDP-glucose:crocetin glucosyl ester glucosyltransferasee | |
| 2.4.1.331 | 8-demethyltetracenomycin C L-rhamnosyltransferase | False | 1 | 5 | 0 | 1 | dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | dTDP-beta-L-rhamnose:8-demethyltetracenomycin C 3-alpha-L-rhamnosyltransferase | None | elmGT | |
| 2.5.1.124 | 6-linalyl-2-O,3-dimethylflaviolin synthase | False | 1 | 2 | 0 | 1 | geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 6-linalyl-2-O,3-dimethylflaviolin | geranyl-diphosphate:2-O-methyl-3-methylflaviolin geranyltransferase (6-linalyl-2-O,3-dimethylflaviolin-forming) | None | Fur7; 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase | |
| 2.5.1.125 | 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase | False | 1 | 0 | 0 | 1 | geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 7-O-geranyl-2-O,3-dimethylflaviolin | geranyl-diphosphate:2-O,3-dimethylflaviolin geranyltransferase (7-O-geranyl-2-O,3-dimethylflaviolin-forming) | None | Fur7 | |
| 2.5.1.126 | norspermine synthase | False | 4 | 1 | 0 | 1 | S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine = S-methyl-5'-thioadenosine + norspermine | S-adenosyl 3-(methylsulfanyl)propylamine:norspermidine 3-aminopropyltransferase | None | long-chain polyamine synthase (ambiguous) | |
| 2.5.1.127 | caldopentamine synthase | False | 1 | 0 | 0 | 1 | S-adenosyl 3-(methylsulfanyl)propylamine + norspermine = S-methyl-5'-thioadenosine + caldopentamine | S-adenosyl 3-(methylsulfanyl)propylamine:norspermine 3-aminopropyltransferase | None | long-chain polyamine synthase (ambiguous) | |
| 2.7.1.185 | mevalonate 3-kinase | False | 2 | 2 | 0 | 3 | ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate | ATP:(R)-mevalonate 3-phosphotransferase | None | ATP:(R)-MVA 3-phosphotransferase | |
| 2.7.1.186 | mevalonate-3-phosphate 5-kinase | False | 1 | 2 | 0 | 1 | ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate | ATP:(R)-3-phosphomevalonate 5-phosphotransferase | None | None | |
| 2.7.14.1 | protein arginine kinase | False | 67 | 3909 | 5 | 2 | ATP + a [protein]-L-arginine = ADP + a [protein]-Nomega-phospho-L-arginine | ATP:[protein]-L-arginine Nomega-phosphotransferase | None | McsB | |
| 3.5.4.41 | 5'-deoxyadenosine deaminase | False | 18 | 406 | 0 | 1 | 5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3 | 5'-deoxyadenosine aminohydrolase | None | MJ1541 (gene name); DadD | |
| 3.9.1.2 | protein arginine phosphatase | False | 2 | 65 | 0 | 3 | a [protein]-Nomega-phospho-L-arginine + H2O = a [protein]-L-arginine + phosphate | [protein]-Nomega-phospho-L-arginine phosphohydrolase | None | YwlE | |
| 4.1.1.99 | phosphomevalonate decarboxylase | False | 1 | 18 | 0 | 1 | ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 | ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming) | None | None | |
| 4.2.3.147 | pimaradiene synthase | False | 2 | 0 | 0 | 3 | (+)-copalyl diphosphate = pimara-8(14),15-diene + diphosphate | (+)-copalyl diphosphate-lyase (pimara-8(14),15-diene-forming) | None | PbmPIM1; PcmPIM1 | |
| 5.1.3.30 | D-psicose 3-epimerase | False | 3 | 226 | 1 | 8 | D-psicose = D-fructose | D-psicose 3-epimerase | None | D-allulose 3-epimerase; DPEase (ambiguous) | |
| 5.1.3.31 | D-tagatose 3-epimerase | False | 4 | 249 | 1 | 6 | (1) D-tagatose = D-sorbose;;(2) D-psicose = D-fructose | D-tagatose 3-epimerase | None | L-ribulose 3-epimerase; ketose 3-epimerase | |
| 5.1.3.32 | L-rhamnose mutarotase | False | 100 | 4645 | 1 | 2 | alpha-L-rhamnopyranose = beta-L-rhamnopyranose | L-rhamnopyranose 1-epimerase | None | rhamnose 1-epimerase; type-3 mutarotase; YiiL | |
| 5.4.99.62 | D-ribose pyranase | False | 207 | 7022 | 0 | 3 | beta-D-ribopyranose = beta-D-ribofuranose | D-ribopyranose furanomutase | None | RbsD | |
| 6.2.1.44 | 3-(methylthio)propionyl---CoA ligase | False | 2 | 208 | 0 | 5 | ATP + 3-(methylsulfanyl)propanoate + CoA = AMP + diphosphate + 3-(methylsulfanyl)propanoyl-CoA | 3-(methylsulfanyl)propanoate:CoA ligase (AMP-forming) | None | DmdB; MMPA-CoA ligase; methylmercaptopropionate-coenzyme A ligase; 3-methylmercaptopropionyl-CoA ligase; 3-(methylthio)propanoate:CoA ligase (AMP-forming) | |
| 6.3.2.43 | [amino-group carrier protein]---L-2-aminoadipate ligase | False | 4 | 131 | 0 | 4 | ATP + an [amino-group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] | [amino-group carrier protein]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming) | None | alpha-aminoadipate-lysW ligase; lysX (gene name); LysX (ambiguous); AAA---LysW ligase; [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming); [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase | |
| 6.3.2.44 | pantoate---beta-alanine ligase (ADP-forming) | False | 0 | 1 | 0 | 1 | ATP + (R)-pantoate + beta-alanine = ADP + phosphate + (R)-pantothenate | (R)-pantoate:beta-alanine ligase (ADP-forming) | None | pantothenate synthetase (ambiguous); pantoate---beta-alanine ligase (ambiguous) | |
| 6.5.1.6 | DNA ligase (ATP or NAD+) | False | 3 | 130 | 1 | 2 | (1) ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate (overall reaction);;(1a) ATP + [DNA ligase]-L-lysine = 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + diphosphate;;(1b) 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(1c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP;;(2) NAD + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide (overall reaction);;(2a) NAD + [DNA ligase]-L-lysine = 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + beta-nicotinamide D-nucleotide;;(2b) 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(2c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP or NAD+) | None | None | |
| 6.5.1.7 | DNA ligase (ATP, ADP or GTP) | False | 4 | 60 | 0 | 2 | (1) ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate (overall reaction);;(1a) ATP + [DNA ligase]-L-lysine = 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + diphosphate;;(1b) 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(1c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP;;(2) ADP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + phosphate (overall reaction);;(2a) ADP + [DNA ligase]-L-lysine = 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + phosphate;;(2b) 5'-adenosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(2c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP;;(3) GTP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + GMP + diphosphate (overall reaction);;(3a) GTP + [DNA ligase]-L-lysine = 5'-guanosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + diphosphate;;(3b) 5'-guanosyl [DNA ligase]-Nepsilon-phosphono-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoguanosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;;(3c) (deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoguanosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + GMP | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP, ADP or GTP) | None | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (ATP, ADP or GTP) | |
| 1.1.1.379 | (R)-mandelate dehydrogenase | True | 0 | 0 | 0 | 3 | (R)-mandelate + NAD+ = phenylglyoxylate + NADH + H+ | (R)-mandelate:NAD+ 2-oxidoreductase | None | ManDH2; D-ManDH2; D-mandelate dehydrogenase (ambiguous) | |
| 1.1.1.380 | L-gulonate 5-dehydrogenase | False | 0 | 23 | 0 | 3 | L-gulonate + NAD+ = D-fructuronate + NADH + H+ | L-gulonate:NAD+ 5-oxidoreductase | None | None | |
| 1.1.1.381 | 3-hydroxy acid dehydrogenase | False | 8 | 2149 | 0 | 2 | L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH + H+ (overall reaction);;(1a) L-allo-threonine + NADP+ = L-2-amino-3-oxobutanoate + NADPH + H+;;(1b) L-2-amino-3-oxobutanoate = aminoacetone + CO2 (spontaneous) | L-allo-threonine:NADP+ 3-oxidoreductase | None | ydfG (gene name); YMR226c (gene name) | |
| 1.1.3.47 | 5-(hydroxymethyl)furfural oxidase | False | 1 | 63 | 1 | 12 | 5-(hydroxymethyl)furfural + 3 O2 + 2 H2O = furan-2,5-dicarboxylate + 3 H2O2 (overall reaction);;(1a) 5-(hydroxymethyl)furfural + O2 = furan-2,5-dicarbaldehyde + H2O2;;(1b) furan-2,5-dicarbaldehyde + H2O = 5-(dihydroxymethyl)furan-2-carbaldehyde (spontaneous);;(1c) 5-(dihydroxymethyl)furan-2-carbaldehyde + O2 = 5-formylfuran-2-carboxylate + H2O2;;(1d) 5-formylfuran-2-carboxylate + H2O = 5-(dihydroxymethyl)furan-2-carboxylate (spontaneous);;(1e) 5-(dihydroxymethyl)furan-2-carboxylate + O2 = furan-2,5-dicarboxylate + H2O2 | 5-(hydroxymethyl)furfural:oxygen oxidoreductase | None | None | |
| 1.2.1.90 | glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] | False | 2 | 7 | 0 | 2 | D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = 3-phospho-D-glycerate + NAD(P)H + 2 H+ | D-glyceraldehyde-3-phosphate:NAD(P)+ oxidoreductase | None | non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (ambiguous); GAPN | |
| 1.2.1.91 | 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase | False | 1 | 192 | 0 | 2 | 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP+ + H2O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+ | 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase | None | paaZ (gene name) | |
| 1.2.1.92 | 3,6-anhydro-alpha-L-galactose dehydrogenase | False | 2 | 12 | 0 | 3 | 3,6-anhydro-alpha-L-galactopyranose + NAD(P)+ + H2O = 3,6-anhydro-L-galactonate + NAD(P)H + H+ | 3,6-anhydro-alpha-L-galactopyranose:NAD(P)+ 1-oxidoredutase | None | None | |
| 1.9.98.1 | iron---cytochrome-c reductase | True | 0 | 0 | 0 | 1 | ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+ | ferrocytochrome-c:Fe3+ oxidoreductase | None | iron-cytochrome c reductase | |
| 1.17.4.4 | vitamin-K-epoxide reductase (warfarin-sensitive) | False | 8 | 2253 | 9 | 18 | (1) phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues;;(2) phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues | phylloquinone:disulfide oxidoreductase | None | VKORC1 (gene name); VKORC1L1 (gene name) | |
| 1.17.4.5 | vitamin-K-epoxide reductase (warfarin-insensitive) | True | 0 | 0 | 0 | 3 | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase | None | None | |
| 1.17.99.6 | epoxyqueuosine reductase | False | 41 | 29161 | 6 | 6 | queuosine34 in tRNA + acceptor + H2O = epoxyqueuosine34 in tRNA + reduced acceptor | queuosine34 in tRNA:acceptor oxidoreductase | None | oQ reductase; queG (gene name); queH (gene name) | |
| 1.21.98.1 | cyclic dehypoxanthinyl futalosine synthase | False | 2 | 5544 | 0 | 2 | dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinyl futalosine + 5'-deoxyadenosine + L-methionine | dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing) | None | MqnC; dehypoxanthinyl futalosine cyclase | |
| 2.1.1.308 | cytidylyl-2-hydroxyethylphosphonate methyltransferase | False | 1 | 76 | 0 | 2 | 2 S-adenosyl-L-methionine + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + oxidized acceptor | S-adenosyl-L-methionine:cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} C-methyltransferase | None | Fom3; S-adenosyl-L-methionine:methylcob(III)alamin:2-hydroxyethylphosphonate methyltransferase (incorrect); 2-hydroxyethylphosphonate methyltransferase (incorrect) | |
| 2.1.1.309 | 18S rRNA (guanine1575-N7)-methyltransferase | False | 2 | 65 | 4 | 2 | S-adenosyl-L-methionine + guanine1575 in 18S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine1575 in 18S rRNA | S-adenosyl-L-methionine:18S rRNA (guanine1575-N7)-methyltransferase | None | 18S rRNA methylase Bud23; BUD23 (gene name) | |
| 2.1.1.310 | 25S rRNA (cytosine2870-C5)-methyltransferase | False | 1 | 61 | 4 | 2 | S-adenosyl-L-methionine + cytosine2870 in 25S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA | S-adenosyl-L-methionine:25S rRNA (cytosine2870-C5)-methyltransferase | None | NOP2 (gene name) | |
| 2.1.1.311 | 25S rRNA (cytosine2278-C5)-methyltransferase | False | 1 | 25 | 0 | 1 | S-adenosyl-L-methionine + cytosine2278 in 25S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA | S-adenosyl-L-methionine:25S rRNA (cytosine2278-C5)-methyltransferase | None | RCM1 (gene name) | |
| 2.1.1.312 | 25S rRNA (uracil2843-N3)-methyltransferase | False | 1 | 4 | 0 | 1 | S-adenosyl-L-methionine + uracil2843 in 25S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil2843 in 25S rRNA | S-adenosyl-L-methionine:tRNA (uracil2843-N3)-methyltransferase | None | BMT6 | |
| 2.1.1.313 | 25S rRNA (uracil2634-N3)-methyltransferase | False | 1 | 18 | 0 | 1 | S-adenosyl-L-methionine + uracil2634 in 25S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil2634 in 25S rRNA | S-adenosyl-L-methionine:tRNA (uracil2634-N3)-methyltransferase | None | BMT5 | |
| 2.2.1.12 | 3-acetyloctanal synthase | False | 2 | 0 | 0 | 2 | pyruvate + (E)-oct-2-enal = (S)-3-acetyloctanal + CO2 | pyruvate:(E)-oct-2-enal acetaldehydetransferase (decarboxylating) | None | pigD (gene name) | |
| 2.3.1.234 | N6-L-threonylcarbamoyladenine synthase | False | 772 | 56369 | 10 | 4 | L-threonylcarbamoyladenylate + adenine37 in tRNA = AMP + N6-L-threonylcarbamoyladenine37 in tRNA | L-threonylcarbamoyladenylate:adenine37 in tRNA N6-L-threonylcarbamoyltransferase | None | t6A synthase; Kae1; ygjD (gene name); Qri7 | |
| 2.3.1.235 | tetracenomycin F2 synthase | False | 5 | 67 | 0 | 1 | 10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O | malonyl-CoA:acetate malonyltransferase (tetracenomycin-F2-forming) | None | TCM PKS | |
| 2.3.1.236 | 5-methylnaphthoic acid synthase | False | 1 | 1 | 0 | 1 | acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ | malonyl-CoA:acetyl-CoA malonyltransferase (5-methyl-1-naphthoic acid-forming) | None | AziB | |
| 2.3.1.237 | neocarzinostatin naphthoate synthase | False | 1 | 0 | 0 | 1 | acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+ | malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid-forming) | None | naphthoic acid synthase; NNS; ncsB (gene name) | |
| 2.3.1.238 | monacolin J acid methylbutanoate transferase | False | 3 | 6 | 0 | 1 | monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase] | monacolin J acid:(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] (S)-2-methylbutanoate transferase | None | LovD | |
| 2.3.1.239 | 10-deoxymethynolide synthase | False | 4 | 101 | 2 | 1 | malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = 10-deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O | (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide-forming) | None | pikromycin PKS | |
| 2.3.1.240 | narbonolide synthase | False | 4 | 2 | 0 | 1 | malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O | (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide-forming) | None | pikromycin PKS | |
| 2.3.1.241 | Kdo2-lipid IVA acyltransferase | False | 3 | 6184 | 0 | 5 | a fatty acyl-[acyl-carrier protein] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] + an [acyl-carrier protein] | fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] O-acyltransferase | None | LpxL; htrB (gene name); dodecanoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA O-dodecanoyltransferase; lauroyl-[acyl-carrier protein]:Kdo2-lipid IVA O-lauroyltransferase; (Kdo)2-lipid IVA lauroyltransferase; alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA lauroyltransferase; dodecanoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-dodecanoyltransferase; Kdo2-lipid IVA lauroyltransferase | |
| 2.3.1.242 | Kdo2-lipid IVA palmitoleoyltransferase | False | 2 | 1232 | 0 | 5 | a (9Z)-hexadec-9-enoyl-[acyl-carrier protein] + Kdo2-lipid IVA = (9Z)-hexadec-9-enoyl-Kdo2-lipid IVA + an [acyl-carrier protein] | (9Z)-hexadec-9-enoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-palmitoleoyltransferase | None | LpxP; palmitoleoyl-acyl carrier protein-dependent acyltransferase; cold-induced palmitoleoyl transferase; palmitoleoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-palmitoleoyltransferase; (Kdo)2-lipid IVA palmitoleoyltransferase; alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA palmitoleoyltransferase | |
| 2.3.1.243 | acyl-Kdo2-lipid IVA acyltransferase | False | 4 | 2097 | 0 | 8 | a fatty acyl-[acyl-carrier protein] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-[lipid IVA] + an [acyl-carrier protein] | fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] O-acyltransferase | None | lpxM (gene name); MsbB acyltransferase; myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase; tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase; lauroyl-Kdo2-lipid IVA myristoyltransferase | |
| 2.4.1.332 | 1,2-alpha-glucosylglycerol phosphorylase | False | 1 | 0 | 0 | 1 | 2-O-alpha-D-glucopyranosyl-glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol | 2-O-alpha-D-glucopyranosyl-glycerol:phosphate beta-D-glucosyltransferase | None | 2-O-alpha-D-glucopyranosylglycerol phosphorylase | |
| 2.4.1.333 | 1,2-beta-oligoglucan phosphorylase | False | 1 | 10 | 4 | 2 | [(1->2)-beta-D-glucosyl]n + phosphate = [(1->2)-beta-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | 1,2-beta-D-glucan:phosphate alpha-D-glucosyltransferase | None | None | |
| 2.4.1.334 | 1,3-alpha-oligoglucan phosphorylase | True | 0 | 0 | 0 | 1 | [(1->3)-alpha-D-glucosyl]n + phosphate = [(1->3)-alpha-D-glucosyl]n-1 + beta-D-glucose 1-phosphate | 1,3-alpha-D-glucan:phosphate beta-D-glucosyltransferase | None | None | |
| 2.5.1.128 | N4-bis(aminopropyl)spermidine synthase | False | 3 | 408 | 6 | 1 | 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine (overall reaction);; (1a) S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + N4-aminopropylspermidine;; (1b) S-adenosyl 3-(methylsulfanyl)propylamine + N4-aminopropylspermidine = S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine | S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase [N4-bis(aminopropyl)spermidine synthesizing] | None | None | |
| 3.1.1.97 | methylated diphthine methylhydrolase | False | 5 | 2864 | 0 | 2 | diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol | diphthine methyl ester acylhydrolase | None | Dph7; diphthine methylesterase (incorrect) | |
| 3.1.3.96 | pseudouridine 5'-phosphatase | False | 4 | 31 | 0 | 1 | pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate | pseudouridine 5'-phosphohydrolase | None | pseudouridine 5'-monophosphatase; 5'-PsiMPase; HDHD1 | |
| 3.5.2.20 | isatin hydrolase | False | 1 | 34 | 0 | 5 | isatin + H2O = isatinate | isatin amidohydrolase | None | None | |
| 3.6.1.67 | dihydroneopterin triphosphate diphosphatase | False | 5 | 1706 | 3 | 3 | 7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate | 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase | None | folQ (gene name); nudB (gene name); NUDT1 (gene name); dihydroneopterin triphosphate pyrophosphohydrolase | |
| 4.2.3.148 | cembrene C synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = cembrene C + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cembrene-C-forming) | None | DtcycA (gene name) | |
| 4.2.3.149 | nephthenol synthase | False | 2 | 0 | 0 | 1 | geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming] | None | DtcycA (gene name); DtcycB (gene name) | |
| 4.2.3.150 | cembrene A synthase | False | 1 | 1 | 0 | 4 | geranylgeranyl diphosphate = (R)-cembrene A + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [(R)-cembrene-A-forming] | None | DtcycB (gene name) | |
| 4.2.3.151 | pentamethylcyclopentadecatrienol synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol-forming] | None | DtcycB (gene name) | |
| 4.4.1.28 | L-cysteine desulfidase | False | 10 | 33 | 0 | 10 | L-cysteine + H2O = sulfide + NH3 + pyruvate (overall reaction);; (1a) L-cysteine = 2-aminoprop-2-enoate + sulfide;; (1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);; (1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-cysteine sulfide-lyase (deaminating; pyruvate-forming) | None | L-cysteine desulfhydrase | |
| 5.5.1.25 | 3,6-anhydro-L-galactonate cycloisomerase | False | 2 | 37 | 3 | 2 | 3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate | 3,6-anhydro-L-galactonate lyase (ring-opening) | None | 3,6-anhydro-alpha-L-galactonate lyase (ring-opening); 3,6-anhydro-alpha-L-galactonate cycloisomerase | |
| 6.3.2.45 | UDP-N-acetylmuramate---L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase | False | 2 | 8531 | 0 | 1 | ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase2015 | None | murein peptide ligase; Mpl; yjfG (gene name); UDP-MurNAc:L-Ala-gamma-D-Glu-meso-A2pm ligase; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase | |
| 6.3.4.24 | tyramine---L-glutamate ligase | False | 2 | 26 | 0 | 1 | ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine | tyramine:L-glutamate gamma-ligase (ADP-forming) | None | mfnD (gene name) | |
| 1.14.99.50 | gamma-glutamyl hercynylcysteine S-oxide synthase | False | 4 | 2493 | 0 | 3 | hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | hercynine,gamma-L-glutamyl-L-cysteine:oxygen oxidoreductase [gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | None | EgtB | |
| 1.1.1.382 | ketol-acid reductoisomerase (NAD+) | False | 3 | 32 | 0 | 6 | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2R)-2,3-dihydroxy-3-methylbutanoate:NAD+ oxidoreductase (isomerizing) | None | None | |
| 1.1.1.383 | ketol-acid reductoisomerase [NAD(P)+] | False | 5 | 2 | 0 | 8 | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(P)+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NAD(P)H + H+ | (2R)-2,3-dihydroxy-3-methylbutanoate:NAD(P)+ oxidoreductase (isomerizing) | None | None | |
| 1.1.1.384 | dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase | False | 4 | 18 | 0 | 4 | dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ | dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose:NADP+ 3-oxidoreductase | None | KijD10; dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase; dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase | |
| 1.1.1.385 | dihydroanticapsin dehydrogenase | False | 3 | 712 | 2 | 1 | L-dihydroanticapsin + NAD+ = L-anticapsin + NADH + H+ | L-dihydroanticapsin:NAD+ oxidoreductase | None | BacC; ywfD (gene name) | |
| 1.1.1.386 | ipsdienol dehydrogenase | False | 1 | 0 | 0 | 1 | (R)-ipsdienol + NAD(P)+ = ipsdienone + NAD(P)H + H+ | (R)-ipsdienol:NAD(P)+ oxidoreductase | None | IDOLDH | |
| 1.2.5.2 | aldehyde dehydrogenase (quinone) | False | 4 | 165 | 0 | 12 | an aldehyde + a quinone + H2O = a carboxylate + a quinol | aldehyde:quinone oxidoreductase | None | aldehyde dehydrogenase (acceptor) | |
| 1.2.98.1 | formaldehyde dismutase | False | 2 | 354 | 0 | 6 | 2 formaldehyde + H2O = formate + methanol | formaldehyde:formaldehyde oxidoreductase | None | aldehyde dismutase; cannizzanase; nicotinoprotein aldehyde dismutase | |
| 1.3.8.12 | (2S)-methylsuccinyl-CoA dehydrogenase | False | 1 | 133 | 0 | 2 | (2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein | (2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase | None | Mcd | |
| 1.5.1.49 | 1-pyrroline-2-carboxylate reductase [NAD(P)H] | False | 13 | 357 | 0 | 1 | L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ | L-proline:NAD(P)+ 2-oxidoreductase | None | None | |
| 1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) | False | 4 | 29 | 6 | 6 | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase | None | NRH:quinone oxidoreductase 2; NQO2; NAD(P)H:quinone oxidoreductase-2 (misleading); QR2; quinone reductase 2; N-ribosyldihydronicotinamide dehydrogenase (quinone); NAD(P)H:quinone oxidoreductase2 (misleading) | |
| 1.13.11.80 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | False | 2 | 29 | 3 | 2 | (3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA | (3,5-dihydroxyphenyl)acetyl-CoA:oxygen oxidoreductase | None | DpgC | |
| 1.13.12.22 | deoxynogalonate monooxygenase | False | 1 | 8 | 0 | 1 | deoxynogalonate + O2 = nogalonate + H2O | deoxynogalonate:oxygen oxidoreductase | None | SnoaB (gene name); 12-deoxynogalonic acid oxidoreductase; [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate oxidase; [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate monooxygenase; deoxynogalonate oxidoreductase | |
| 1.14.11.48 | xanthine dioxygenase | False | 4 | 0 | 0 | 1 | xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2 | xanthine,2-oxoglutarate:oxygen oxidoreductase | None | XanA; alpha-ketoglutarate-dependent xanthine hydroxylase | |
| 1.14.19.10 | icosanoyl-CoA 5-desaturase | False | 1 | 0 | 0 | 1 | icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O | icosanoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6 cis-dehydrogenating) | None | acyl-CoA Delta5-desaturase (ambiguous) | |
| 1.23.5.1 | violaxanthin de-epoxidase | False | 4 | 28 | 0 | 18 | violaxanthin + 2 L-ascorbate = zeaxanthin + 2 L-dehydroascorbate + 2 H2O (overall reaction);;(1a) violaxanthin + L-ascorbate = antheraxanthin + L-dehydroascorbate + H2O;;(1b) antheraxanthin + L-ascorbate = zeaxanthin + L-dehydroascorbate + H2O | violaxanthin:ascorbate oxidoreductase | None | VDE | |
| 2.1.1.314 | diphthine methyl ester synthase | False | 18 | 3806 | 0 | 4 | 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] | S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine methyl ester-[translation elongation factor 2]-forming) | None | S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); Dph5 (ambiguous) | |
| 2.1.1.315 | 27-O-demethylrifamycin SV methyltransferase | False | 1 | 86 | 0 | 1 | S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV | S-adenosyl-L-methionine:27-O-demethylrifamycin-SV 27-O-methyltransferase | None | AdoMet:27-O-demethylrifamycin SV methyltransferase | |
| 2.3.1.244 | 2-methylbutanoate polyketide synthase | False | 4 | 0 | 0 | 1 | 2 malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 3 H+ + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + 2 CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O | acyl-CoA:malonyl-CoA C-acyltransferase (2-methylbutanoate-forming) | None | LovF | |
| 2.3.1.245 | 3-hydroxy-5-phosphooxypentane-2,4-dione thiolase | False | 27 | 1782 | 0 | 1 | glycerone phosphate + acetyl-CoA = 3-hydroxy-2,4-dioxopentyl phosphate + CoA | acetyl-CoA:glycerone phosphate C-acetyltransferase | None | lsrF (gene name); 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase | |
| 2.3.1.246 | 3,5-dihydroxyphenylacetyl-CoA synthase | False | 3 | 11 | 0 | 2 | 4 malonyl-CoA = (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O | malonyl-CoA:malonyl-CoA malonyltransferase (3,5-dihydroxyphenylacetyl-CoA-forming) | None | DpgA | |
| 2.7.1.187 | acarbose 7IV-phosphotransferase | False | 1 | 14 | 1 | 1 | ATP + acarbose = ADP + acarbose 7IV-phosphate | ATP:acarbose 7IV-phosphotransferase | None | acarbose 7-kinase; AcbK | |
| 2.7.1.188 | 2-epi-5-epi-valiolone 7-kinase | False | 1 | 1 | 0 | 1 | ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate | ATP:2-epi-5-epi-valiolone 7-phosphotransferase | None | AcbM | |
| 2.7.4.29 | Kdo2-lipid A phosphotransferase | False | 1 | 1167 | 0 | 2 | ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate | ditrans-octacis-undecaprenyl-diphosphate:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A phosphotransferase | None | lipid A undecaprenyl phosphotransferase; LpxT; YeiU | |
| 3.1.2.31 | dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase | False | 3 | 0 | 0 | 0 | dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid | dihydromonacolin L-[lovastatin nonaketide synthase] hydrolase | None | LovG | |
| 3.1.3.97 | 3',5'-nucleoside bisphosphate phosphatase | False | 4 | 219 | 0 | 0 | nucleoside 3',5'-bisphosphate + H2O = nucleoside 5'-phosphate + phosphate | nucleoside-3',5'-bisphosphate 3'-phosphohydrolase | None | None | |
| 3.3.2.14 | 2,4-dinitroanisole O-demethylase | False | 2 | 11 | 0 | 1 | 2,4-dinitroanisole + H2O = methanol + 2,4-dinitrophenol | 2,4-dinitroanisole methanol hydrolase | None | 2,4-dinitroanisole ether hydrolase; dnhA (gene name); dnhB (gene name); DNAN demethylase | |
| 3.4.14.13 | gamma-D-glutamyl-L-lysine dipeptidyl-peptidase | False | 2 | 47 | 0 | 2 | The enzyme releases L-Ala-gamma-D-Glu dipeptides from cell wall peptides via cleavage of an L-Ala-gamma-D-Glu!L-Lys bond. | None | None | YkfC | |
| 3.5.1.118 | gamma-glutamyl hercynylcysteine S-oxide hydrolase | False | 3 | 2524 | 0 | 1 | gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate | gamma-glutamyl-S-(hercyn-2-yl)cysteine S-oxide amidohydrolase | None | EgtC | |
| 4.1.1.100 | prephenate decarboxylase | False | 4 | 22 | 0 | 3 | prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 | prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming) | None | BacA; AerD; SalX; non-aromatizing prephenate decarboxylase | |
| 4.2.1.155 | (methylthio)acryloyl-CoA hydratase | False | 1 | 44 | 0 | 1 | 3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2 (overall reaction);;(1a) 3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA;;(1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol;;(1c) 3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA;;(1d) 3-oxopropanoate = acetaldehyde + CO2 | 3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming) | None | DmdD | |
| 4.2.3.152 | 2-epi-5-epi-valiolone synthase | False | 6 | 395 | 0 | 5 | alpha-D-sedoheptulopyranose 7-phosphate = 2-epi-5-epi-valiolone + phosphate | alpha-D-sedoheptulopyranose-7-phosphate phosphate-lyase (cyclizing; 2-epi-5-epi-valiolone-forming) | None | AcbC; ValA; CetA; SalQ; C7-cyclitol synthase | |
| 4.4.1.29 | phycobiliprotein cysteine-84 phycobilin lyase | True | 0 | 0 | 0 | 7 | (1) [C-phycocyanin beta-subunit]-Cys84-phycocyanobilin = apo-[C-phycocyanin beta-subunit] + (2R,3E)-phycocyanobilin;;(2) [phycoerythrocyanin beta-subunit]-Cys84-phycocyanobilin = apo-[phycoerythrocyanin beta-subunit] + (2R,3E)-phycocyanobilin;;(3) [allophycocyanin alpha-subunit]-Cys84-phycocyanobilin = apo-[allophycocyanin alpha-subunit] + (2R,3E)-phycocyanobilin;;(4) [allophycocyanin beta-subunit]-Cys84-phycocyanobilin = apo-[allophycocyanin beta-subunit] + (2R,3E)-phycocyanobilin;;(5) [C-phycoerythrin alpha-subunit]-Cys84-phycoerythrobilin = apo-[C-phycoerythrin alpha-subunit] + (2R,3E)-phycoerythrobilin;;(6) [C-phycoerythrin beta-subunit]-Cys84-phycoerythrobilin = apo-[C-phycoerythrin beta-subunit] + (2R,3E)-phycoerythrobilin;; | [phycobiliprotein]-Cys84-phycobilin:phycobilin lyase | None | cpcS (gene name); cpeS (gene name); cpcS1 (gene name); cpcU (gene name); phycocyanobilin:Cys-beta84-phycobiliprotein lyase | |
| 4.4.1.30 | phycobiliprotein beta-cysteine-155 phycobilin lyase | True | 0 | 0 | 0 | 5 | (1) [C-phycocyanin beta-subunit]-Cys155-phycocyanobilin = apo-[C-phycocyanin beta-subunit] + (2R,3E)-phycocyanobilin;;(2) [phycoerythrocyanin beta-subunit]-Cys155-phycocyanobilin = apo-[phycoerythrocyanin beta-subunit] + (2R,3E)-phycocyanobilin | [phycobiliprotein beta-subunit]-Cys155-phycocyanobilin:phycocyanobilin lyase | None | cpcT (gene name); cpeT1 (gene name); cpcT1 (gene name) | |
| 4.4.1.31 | phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase | True | 0 | 0 | 0 | 3 | [phycoerythrocyanin alpha-subunit]-Cys84-phycoviolobilin = apo-[phycoerythrocyanin alpha-subunit] + (2R,3E)-phycocyanobilin | [phycoerythrocyanin alpha-subunit]-Cys84-phycoviolobilin:(2R,3E)-phycocyanobilin lyase/isomerase | None | pecE (gene name); pecF (gene name); phycoviolobilin phycoerythrocyanin-alpha84-cystein-lyase; PecE/PecF; PEC-Cys-R84 PCB lyase/isomerase | |
| 4.4.1.32 | C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase | True | 0 | 0 | 0 | 5 | [C-phycocyanin alpha-subunit]-Cys84-phycocyanobilin = apo-[C-phycocyanin alpha-subunit] + (2R,3E)-phycocyanobilin | [C-phycocyanin alpha-subunit]-Cys84-phycocyanobilin:(2R,3E)-phycocyanobilin lyase | None | cpcE (gene name); cpcF (gene name) | |
| 4.4.1.33 | R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase | True | 0 | 0 | 0 | 1 | [R-phycocyanin alpha-subunit]-Cys84-phycourobilin = apo-[R-phycocyanin alpha-subunit] + (2R,3E)-phycoerythrobilin | [R-phycocyanin alpha-subunit]-Cys84-phycourobilin:(2R,3E)-phycoerythrobilin lyase/isomerase | None | rpcG (gene name) | |
| 5.1.1.20 | L-Ala-D/L-Glu epimerase | False | 6 | 116 | 0 | 2 | L-alanyl-D-glutamate = L-alanyl-L-glutamate | L-alanyl-D-glutamate epimerase | None | YkfB; YcjG; AEE; AE epimerase | |
| 5.3.1.32 | (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase | False | 26 | 784 | 0 | 2 | (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate | (2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase | None | lsrG (gene name); phospho-AI-2 isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase | |
| 5.5.1.26 | nogalonic acid methyl ester cyclase | False | 1 | 5 | 0 | 1 | nogalaviketone = methyl nogalonate | nogalaviketone lyase (ring-opening) | None | methyl nogalonate cyclase; SnoaL (gene name); methyl nogalonate lyase (cyclizing) | |
| 6.3.2.46 | fumarate---(S)-2,3-diaminopropanoate ligase | False | 1 | 3 | 0 | 1 | ATP + fumarate + L-2,3-diaminopropanoate = AMP + diphosphate + N3-fumaroyl-L-2,3-diaminopropanoate | fumarate:L-2,3-diaminopropanoate ligase (AMP-forming) | None | DdaG; fumarate:(S)-2,3-diaminopropanoate ligase (AMP-forming) | |
| 6.3.2.47 | dapdiamide synthase | False | 1 | 21 | 0 | 1 | (1) ATP + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanine + L-valine = ADP + phosphate + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanyl-L-valine;;(2) ATP + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanine + L-isoleucine = ADP + phosphate + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanyl-L-isoleucine;;(3) ATP + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanine + L-leucine = ADP + phosphate + 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanyl-L-leucine;;(4) ATP + 3-({[(2R,3R)-3-carbamoyloxiran-2-yl]carbonyl}amino)-L-alanine + L-valine = ADP + phosphate + 3-({[(2R,3R)-3-carbamoyloxiran-2-yl]carbonyl}amino)-L-alanyl-L-valine | 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanine:L-valine ligase (ADP-forming) | None | DdaF; dapdiamide A synthase | |
| 1.1.1.387 | L-serine 3-dehydrogenase (NAD+) | False | 1 | 1 | 0 | 2 | L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction);; (1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+;; (1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) | L-serine:NAD+ 3-oxidoreductase | None | NAD+-dependent L-serine dehydrogenase | |
| 1.1.1.388 | glucose-6-phosphate dehydrogenase (NAD+) | False | 1 | 374 | 0 | 1 | D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ | D-glucose-6-phosphate:NAD+ 1-oxidoreductase | None | Glc6PDH; azf (gene name); archaeal zwischenferment | |
| 1.1.3.48 | 3-deoxy-alpha-D-manno-octulosonate 8-oxidase | False | 1 | 21 | 1 | 1 | 3-deoxy-alpha-D-manno-octulopyranosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 | 3-deoxy-alpha-D-manno-octulopyranosonate:oxygen 8-oxidoreductase | None | kdnB (gene name) | |
| 1.2.1.94 | farnesal dehydrogenase | False | 5 | 725 | 0 | 4 | (2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+ | farnesal:NAD+ oxidoreductase | None | AaALDH3 | |
| 1.2.1.95 | L-2-aminoadipate reductase | False | 6 | 1580 | 0 | 9 | (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate = L-2-aminoadipate + NADPH + H+ + ATP (overall reaction);;(1a) L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + AMP + diphosphate = L-2-aminoadipate + holo-[LYS2 peptidyl-carrier-protein] + ATP;;(1b) (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier-protein] + NADP+ = L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + NADPH + H+ | (S)-2-amino-6-oxohexanoate:NADP+ oxidoreductase (ATP-forming) | None | LYS2; alpha-aminoadipate reductase | |
| 1.3.7.11 | 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase | False | 13 | 622 | 0 | 4 | a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+ | 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase | None | AF0464 (gene name); 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor) | |
| 1.3.99.37 | 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase | False | 1 | 28 | 0 | 5 | (1) dihydroisopentenyldehydrorhodopin + acceptor = isopentenyldehydrorhodopin + reduced acceptor;; (2) dihydrobisanhydrobacterioruberin + acceptor = bisanhydrobacterioruberin + reduced acceptor | dihydroisopentenyldehydrorhodopin:acceptor 3,4-oxidoreductase | None | crtD (gene name) | |
| 1.4.99.6 | D-arginine dehydrogenase | False | 1 | 1279 | 3 | 5 | D-arginine + acceptor + H2O = 5-guanidino-2-oxopentanoate + NH3 + reduced acceptor (overall reaction);;(1a) D-arginine + acceptor = iminoarginine + reduced acceptor;;(1b) iminoarginine + H2O = 5-guanidino-2-oxopentanoate + NH3 (spontaneous) | D-arginine:acceptor oxidoreductase (deaminating) | None | D-amino-acid:(acceptor) oxidoreductase (deaminating); D-amino-acid dehydrogenase; D-amino-acid:acceptor oxidoreductase (deaminating) | |
| 1.5.1.50 | dihydromonapterin reductase | False | 18 | 2315 | 0 | 1 | 5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+ | 5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase | None | FolM; H2-MPt reductase | |
| 1.6.1.4 | NAD(P)+ transhydrogenase (ferredoxin) | False | 0 | 0 | 2 | 7 | NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster | NADH:NADP+, ferredoxin oxidoreductase | None | NADH-dependent reduced ferredoxin:NADP+ oxidoreductase; Nfn; nfnAB (gene names) | |
| 1.14.12.23 | nitroarene dioxygenase | True | 0 | 0 | 0 | 6 | nitrobenzene + NADH + O2 = catechol + nitrite + NAD+ | nitrobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating, nitrite-releasing) | None | cnbA (gene name) | |
| 1.14.18.4 | phosphatidylcholine 12-monooxygenase | False | 1 | 0 | 0 | 4 | a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + 2 ferrocytochrome b5 + O2 + 2 H+ = a 1-acyl-2-[(12R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 ferricytochrome b5 + H2O | 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,ferrocytochrome-b5:oxygen oxidoreductase (12-hydroxylating) | None | ricinoleic acid synthase; oleate Delta12-hydroxylase; oleate Delta12-monooxygenase | |
| 1.14.18.5 | sphingolipid C4-monooxygenase | False | 7 | 59 | 0 | 8 | a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O | dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating) | None | sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH2 (gene name); DEGS2 (gene name) | |
| 1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | False | 1 | 7 | 0 | 4 | a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O | (4R)-4-hydroxysphinganine ceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating) | None | FA2H (gene name); SCS7 (gene name) | |
| 1.14.18.7 | dihydroceramide fatty acyl 2-hydroxylase | False | 3 | 1 | 0 | 2 | a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxydihydroceramide + 2 ferricytochrome b5 + H2O | dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating) | None | FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase | |
| 1.14.19.11 | acyl-[acyl-carrier-protein] 4-desaturase | False | 6 | 131 | 0 | 3 | palmitoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = (4Z)-hexadec-4-enoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | palmitoyl-[acyl-carrier protein],reduced acceptor:oxygen oxidoreductase (4,5 cis-dehydrogenating) | None | Delta4-palmitoyl-[acyl carrier protein] desaturase | |
| 1.14.19.12 | acyl-lipid omega-(9-4) desaturase | False | 1 | 0 | 0 | 1 | (1) linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = coniferonoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;; | acyl-[glycerolipid],ferrocytochrome b5:oxygen oxidoreductase [omega(9-4),omega(9-5) cis-dehydrogenating] | None | acyl-lipid omega-13 desaturase; acyl-lipid 7-desaturase (ambiguous) | |
| 1.14.19.13 | acyl-CoA 15-desaturase | False | 1 | 2 | 0 | 7 | (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + reduced acceptor + O2 = (9Z,12Z,15Z)-hexadeca-9,12,15-trienoyl-CoA + acceptor + 2 H2O | acyl-CoA,reduced acceptor:oxygen oxidoreductase (15,16 cis-dehydrogenating) | None | DES3 (gene name) | |
| 1.14.19.14 | linoleoyl-lipid Delta9 conjugase | False | 2 | 0 | 0 | 2 | a linoleoyl-[glycerolipid] + reduced acceptor + O2 = an (8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + 2 H2O | linoleoyl-lipid,reduced acceptor:oxygen 8,11-allylic oxidase (8E,10E-forming) | None | None | |
| 1.14.19.15 | (11Z)-hexadec-11-enoyl-CoA conjugase | False | 1 | 0 | 0 | 1 | (11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2 = (10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + 2 H2O | (11Z)-hexadec-11-enoyl-CoA,reduced acceptor:oxygen 10,13-allylic oxidase (10E,12E-forming) | None | Bmpgdesat1 (gene name) | |
| 1.14.19.16 | linoleoyl-lipid Delta12 conjugase (11E,13Z-forming) | False | 2 | 0 | 0 | 2 | a linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | linoleoyl-lipid,ferrocytochrome-b5:oxygen 11,14 allylic oxidase (11E,13Z-forming) | None | Fac (gene name) | |
| 1.14.19.17 | sphingolipid 4-desaturase | False | 20 | 3628 | 0 | 10 | a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O | dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating) | None | dehydroceramide desaturase | |
| 1.14.19.18 | sphingolipid 8-(E)-desaturase | False | 6 | 2104 | 0 | 7 | a (4E)-sphing-4-enine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E,8E)-sphing-4,8-dienine ceramide + 2 ferricytochrome b5 + 2 H2O | (4E)-sphing-4-enine ceramide,ferrocytochrome b5:oxygen oxidoreductase (8,9-trans dehydrogenating) | None | 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous) | |
| 1.14.19.19 | sphingolipid 10-desaturase | False | 1 | 0 | 0 | 3 | a (4E,8E)-sphinga-4,8-dienine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E,8E,10E)-sphinga-4,8,10-trienine ceramide + 2 ferricytochrome b5 + 2 H2O | a (4E,8E)-sphinga-4,8-dienine ceramide,ferrocytochrome b5:oxygen oxidoreductase (10,11 trans-dehydrogenating) | None | desA (gene name) | |
| 1.14.19.20 | Delta7-sterol 5(6)-desaturase | False | 18 | 131 | 0 | 11 | a Delta7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Delta5,7-sterol + 2 ferricytochrome b5 + 2 H2O | Delta7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating | None | lathosterol oxidase; Delta7-sterol Delta5-dehydrogenase; Delta7-sterol 5-desaturase; Delta7-sterol-C5(6)-desaturase; 5-DES; SC5DL (gene name); ERG3 (gene name) | |
| 1.14.19.21 | cholesterol 7-desaturase | False | 8 | 3831 | 0 | 8 | cholesterol + O2 + NAD(P)H + H+ = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O | cholesterol,NAD(P)H:oxygen oxidoreductase (7,8 dehydrogenating) | None | nvd (gene name); daf-36 (gene name) | |
| 1.14.19.22 | acyl-lipid omega-6 desaturase (cytochrome b5) | False | 1 | 21 | 0 | 32 | an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,ferrocytochrome-b5:oxygen oxidoreductase (12,13 cis-dehydrogenating) | None | oleate desaturase (ambiguous); linoleate synthase (ambiguous); oleoyl-CoA desaturase (incorrect); oleoylphosphatidylcholine desaturase (ambiguous); phosphatidylcholine desaturase (ambiguous); n-6 desaturase (ambiguous); FAD2 (gene name) | |
| 1.14.19.23 | acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) | False | 4 | 12 | 0 | 3 | an oleoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | oleoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (12,13 cis-dehydrogenating) | None | acyl-lipid omega6-desaturase (ferredoxin); oleate desaturase (ambiguous); linoleate synthase (ambiguous); oleoyl-CoA desaturase (ambiguous); oleoylphosphatidylcholine desaturase (ambiguous); phosphatidylcholine desaturase (ambiguous); FAD6 (gene name) | |
| 1.14.19.24 | acyl-CoA 11-(E)-desaturase | True | 0 | 0 | 0 | 8 | an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O | acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 trans-dehydrogenating) | None | None | |
| 1.14.19.25 | acyl-lipid omega-3 desaturase (cytochrome b5) | False | 3 | 13 | 0 | 12 | a linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an alpha-linolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | (9Z,12Z)-octadeca-9,12-dienoyl-[glycerolipid],ferrocytochrome b5:oxygen oxidoreductase (15,16 cis-dehydrogenating) | None | FAD3 | |
| 1.14.19.26 | acyl-[acyl-carrier-protein] 6-desaturase | False | 1 | 4 | 1 | 3 | palmitoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = (6Z)-hexadec-6-enoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | palmitoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (6,7 cis-dehydrogenating) | None | DELTA6 palmitoyl-ACP desaturase; DELTA6 16:0-ACP desaturase | |
| 1.14.19.27 | sn-2 palmitoyl-lipid 9-desaturase | False | 1 | 0 | 0 | 2 | a 1-acyl-2-palmitoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-acyl-2-palmitoleoyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-acyl-2-palmitoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating) | None | DesC2 | |
| 1.14.19.28 | sn-1 stearoyl-lipid 9-desaturase | False | 2 | 0 | 0 | 9 | a 1-stearoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-oleoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-stearoyl-2-acyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating) | None | desC (gene name) | |
| 1.14.19.29 | sphingolipid 8-(E/Z)-desaturase | False | 4 | 2 | 0 | 20 | (1) a (4R)-4-hydroxysphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R,8E)-4-hydroxysphing-8-enine ceramide + 2 ferricytochrome b5 + 2 H2O;;(2) a (4R)-4-hydroxysphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 ferricytochrome b5 + 2 H2O | (4R)-4-hydroxysphinganine ceramide,ferrocytochrome b5:oxygen oxidoreductase (8,9 cis/trans-dehydrogenating) | None | 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous) | |
| 1.14.19.30 | acyl-lipid (8-3)-desaturase | False | 5 | 0 | 0 | 21 | (1) an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta8 acyl-lipid,ferrocytochrome b5:oxygen oxidoreductase (5,6 cis-dehydrogenating) | None | acyl-lipid 5-desaturase; Delta5-fatty-acid desaturase; DES5 (gene name); D5des (gene name); FADS1 | |
| 1.14.19.31 | acyl-lipid (7-3)-desaturase | False | 5 | 3 | 0 | 12 | (1) a (7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) a (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta7 acyl-lipid,ferrocytochrome b5:oxygen oxidoreductase (4,5 cis-dehydrogenating) | None | D4Des (gene name); des1 (gene name); CrDelta4FAD (gene name); acyl-lipid 4-desaturase | |
| 1.14.19.32 | palmitoyl-CoA 14-(E/Z)-desaturase | True | 0 | 0 | 0 | 4 | (1) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O;;(2) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14Z)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O | palmitoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (14,15 cis/trans-dehydrogenating) | None | None | |
| 1.14.19.33 | Delta12 acyl-lipid conjugase (11E,13E-forming) | False | 3 | 0 | 0 | 6 | (1) a linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an alpha-eleostearoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = an alpha-parinaroyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta12 acyl-lipid,ferrocytochrome-b5:oxygen 11,14 allylic oxidase (11E,13E-forming) | None | fatty acid Delta12-conjugase (ambiguous); FADX (gene name) | |
| 1.14.19.34 | acyl-lipid (9+3)-(E)-desaturase | False | 2 | 1 | 0 | 3 | (1) an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-octadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) a palmitoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-hexadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta9 acyl-lipid,ferrocytochrome b5:oxygen oxidoreductase (12,13 trans-dehydrogenating) | None | acyl-lipid 12-(E)-desaturase; DsFAD2-1; FADX | |
| 1.14.19.35 | sn-2 acyl-lipid omega-3 desaturase (ferredoxin) | False | 3 | 12 | 0 | 14 | (1) a (7Z,10Z)-hexadeca-7,10-dienoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a (7Z,10Z,13Z)-hexadeca-7,10,13-trienoyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(2) a linoleoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = an alpha-linolenoyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | (7Z,10Z)-hexadeca-7,10-dienoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (13,14 cis-dehydrogenating) | None | FAD7; FAD8 | |
| 1.14.19.36 | sn-1 acyl-lipid omega-3 desaturase (ferredoxin) | False | 2 | 12 | 0 | 5 | (1) a 1-gamma-linolenoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-stearidonoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(2) a 1-linoleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-alpha-linolenoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-gamma-linolenoyl-2-acyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (15,16 cis-dehydrogenating) | None | desB (gene name) | |
| 1.14.99.52 | L-cysteinyl-L-histidinylsulfoxide synthase | True | 0 | 0 | 0 | 6 | L-histidine + L-cysteine + O2 = S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O | L-histidine,L-cysteine:oxygen [S-(L-histidin-5-yl)-L-cysteine S-oxide-forming] | None | OvoA | |
| 1.21.1.1 | iodotyrosine deiodinase | False | 12 | 925 | 4 | 13 | L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction);;(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+;;(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ | L-tyrosine,iodide:NADP+ oxidoreductase (iodinating) | None | iodotyrosine dehalogenase 1; DEHAL1 | |
| 1.21.1.2 | 2,4-dichlorobenzoyl-CoA reductase | True | 0 | 0 | 0 | 2 | 4-chlorobenzoyl-CoA + NADP+ + chloride = 2,4-dichlorobenzoyl-CoA + NADPH + H+ | 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating) | None | None | |
| 1.21.99.3 | thyroxine 5-deiodinase | False | 10 | 0 | 0 | 14 | 3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | 3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating) | None | diiodothyronine 5'-deiodinase (ambiguous); iodothyronine 5-deiodinase; iodothyronine inner ring monodeiodinase; type III iodothyronine deiodinase | |
| 2.1.1.316 | mitomycin 6-O-methyltransferase | False | 1 | 45 | 0 | 1 | (1) S-adenosyl-L-methionine + 6-demethylmitomycin A = S-adenosyl-L-homocysteine + mitomycin A;; (2) S-adenosyl-L-methionine + 6-demethylmitomycin B = S-adenosyl-L-homocysteine + mitomycin B | S-adenosyl-L-methionine:6-demethylmitomycin-A 6-O-methyltransferase | None | MmcR; mitomycin 7-O-methyltransferase (incorrect); S-adenosyl-L-methionine:7-demethylmitomycin-A 7-O-methyltransferase (incorrect) | |
| 2.1.1.317 | sphingolipid C9-methyltransferase | False | 6 | 2173 | 0 | 5 | S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide = S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide | S-adenosyl-L-methionine:(4E,8E)-sphinga-4,8-dienine ceramide C-methyltransferase | None | None | |
| 2.1.1.318 | [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + [trehalose-6-phosphate synthase]-L-cysteine = S-adenosyl-L-homocysteine + [trehalose-6-phosphate synthase]-S-methyl-L-cysteine | S-adenosyl-L-methionine:[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase | None | None | |
| 2.3.1.248 | spermidine disinapoyl transferase | False | 1 | 0 | 1 | 1 | 2 sinapoyl-CoA + spermidine = 2 CoA + N1,N8-bis(sinapoyl)-spermidine | sinapoyl-CoA:spermidine N-(hydroxycinnamoyl)transferase | None | SDT | |
| 2.3.1.249 | spermidine dicoumaroyl transferase | False | 1 | 0 | 0 | 1 | 2 4-coumaroyl-CoA + spermidine = 2 CoA + N1,N8-bis(4-coumaroyl)-spermidine | 4-coumaroyl-CoA:spermidine N-(hydroxycinnamoyl)transferase | None | SCT | |
| 2.3.1.250 | [Wnt protein] O-palmitoleoyl transferase | False | 6 | 1278 | 4 | 7 | (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine | (9Z)-hexadec-9-enoyl-CoA:[Wnt]-L-serine O-hexadecenoyltransferase | None | porcupine; PORCN (gene name) | |
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | False | 258 | 53805 | 113 | 16 | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase | None | ubiquitin-carrier-protein E2; UBC (ambiguous); ubiquitin-conjugating enzyme E2 | |
| 2.3.2.24 | (E3-independent) E2 ubiquitin-conjugating enzyme | False | 32 | 2628 | 2 | 4 | [E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N6-monoubiquitinyl-L-lysine (overall reaction);;(1a) [E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) ubiquitin-conjugating enzyme]-S-monoubiquitinyl-L-cysteine;;(1b) [(E3-independent) E2 ubiquitin-conjugating E2 enzyme]-S-monoubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-monoubiquitinyl-L-lysine | [E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent) | None | E2-230K; UBE2O; E3-independent ubiquitin-conjugating enzyme E2 | |
| 2.3.2.25 | N-terminal E2 ubiquitin-conjugating enzyme | False | 9 | 1666 | 0 | 2 | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein] (overall reaction);;(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[N-terminal ubiquitin-conjugating enzyme]-L-cysteine;;(1b) S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine + N-ubiquitinyl-[acceptor protein]-N-terminal amino acid | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:acceptor protein ubiquitin ligase (peptide bond-forming) | None | Ube2w; N-terminal ubiquitin-conjugating enzyme E2 | |
| 2.3.2.26 | HECT-type E3 ubiquitin transferase | False | 132 | 56733 | 77 | 11 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine (overall reaction);;(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;;(1b) [HECT-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [HECT-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming) | None | HECT E3 ligase (misleading); ubiquitin transferase HECT-E3; S-ubiquitinyl-[HECT-type E3-ubiquitin transferase]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming) | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | False | 1394 | 321105 | 404 | 17 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | None | RING E3 ligase (misleading); ubiquitin transferase RING E3; S-ubiquitinyl-[ubiquitin-conjugating E2 enzyme]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming, RING-type) | |
| 2.3.2.28 | L-allo-isoleucyltransferase | False | 1 | 1 | 0 | 1 | L-allo-isoleucyl-[CmaA peptidyl-carrier protein] + holo-[CmaD peptidyl-carrier protein] = L-allo-isoleucyl-[CmaD peptidyl-carrier protein] + holo-[CmaA peptidyl-carrier protein] | L-allo-isoleucyl-[CmaA peptidyl-carrier protein]:holo-[CmaD peptidyl-carrier protein] L-allo-isoleucyltransferase | None | CmaE | |
| 2.6.1.108 | (5-formylfuran-3-yl)methyl phosphate transaminase | False | 1 | 12 | 0 | 1 | L-alanine + (5-formylfuran-3-yl)methyl phosphate = pyruvate + [5-(aminomethyl)furan-3-yl]methyl phosphate | L-alanine:(5-formylfuran-3-yl)methyl phosphate aminotransferase | None | mfnC (gene name); [5-(hydroxymethyl)furan-3-yl]methyl phosphate transaminase | |
| 2.6.1.109 | 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase | False | 1 | 48 | 1 | 2 | 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + 2-oxoglutarate = 8-dehydro-3-deoxy-alpha-D-manno-octulosonate + L-glutamate | 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate:2-oxoglutarate aminotransferase | None | kdnA (gene name) | |
| 2.7.1.189 | autoinducer-2 kinase | False | 25 | 1103 | 3 | 4 | ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxypentane-2,3-dione 5-phosphate | ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase | None | lsrK (gene name) | |
| 2.7.7.88 | GDP polyribonucleotidyltransferase | False | 78 | 8216 | 0 | 3 | (5')pppAACA-[mRNA] + GDP = diphosphate + G(5')pppAACA-[mRNA] (overall reaction);;(1a) (5')pppAACA-[mRNA] + [protein L]-L-histidine = diphosphate + [protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + H2O;;(1b) [protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + GDP + H2O = [protein L]-L-histidine + G(5')pppAACA-[mRNA] | (5')pppAACA-[mRNA]:GDP 5'-phosphopolyribonucleotidyltransferase [(5')pppAACA-[mRNA]-forming] | None | PRNTase; 5'-triphospho-mRNA:GDP 5'-phosphopolyribonucleotidyltransferase [G(5')ppp-mRNA-forming] | |
| 2.7.7.89 | [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase | False | 136 | 15030 | 0 | 4 | [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP | [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine:phosphate adenylyltransferase | None | adenylyl-[glutamine---synthetase]-deadenylase; [L-glutamate:ammonia ligase (ADP-forming)]-O4-(5'-adenylyl)-L-tyrosine:phosphate adenylyltransferase; [glutamate---ammonia ligase]-adenylyl-L-tyrosine phosphorylase | |
| 2.7.8.42 | Kdo2-lipid A phosphoethanolamine 7''-transferase | False | 2 | 581 | 0 | 2 | (1) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A;;(2) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA | diacylphosphatidylethanolamine:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A 7''-phosphoethanolaminetransferase | None | eptB (gene name) | |
| 2.8.1.13 | tRNA-uridine 2-sulfurtransferase | False | 724 | 41517 | 0 | 3 | a [protein]-S-sulfanyl-L-cysteine + uracil34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouracil34 in tRNA + AMP + diphosphate + acceptor | [protein]-S-sulfanyl-L-cysteine:tRNA (uracil34-2-O)-sulfurtransferase | None | mnmA (gene name) | |
| 2.8.1.14 | tRNA-5-taurinomethyluridine 2-sulfurtransferase | False | 11 | 2769 | 0 | 2 | a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluracil34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouracil34 in tRNA + AMP + diphosphate + acceptor | [protein]-S-sulfanyl-L-cysteine:tRNA (5-taurinomethyluracil34 2-O)-sulfurtransferase | None | MTU1 (gene name); SLM3 (gene name); MTO2 (gene name) | |
| 2.8.3.23 | caffeate CoA-transferase | False | 1 | 42 | 0 | 1 | 3-(3,4-dihydroxyphenyl)propanoyl-CoA + (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate = 3-(3,4-dihydroxyphenyl)propanoate + (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA | 3-(3,4-dihydroxyphenyl)propanoyl-CoA:(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate CoA-transferase | None | CarA | |
| 3.1.1.98 | [Wnt protein] O-palmitoleoyl-L-serine hydrolase | False | 8 | 1113 | 128 | 5 | [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate | [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase | None | Notum | |
| 3.4.24.89 | Pro-Pro endopeptidase | False | 2 | 3 | 19 | 2 | The enzyme catalyses the hydrolytic cleavage of peptide bonds between two proline residues | None | None | metalloprotease CD2830 | |
| 4.1.1.101 | malolactic enzyme | False | 5 | 26 | 0 | 7 | (S)-malate = (S)-lactate + CO2 | (S)-malate carboxy-lyase | None | mleA (gene name); mleS (gene name) | |
| 4.2.1.156 | L-talarate dehydratase | False | 1 | 115 | 0 | 1 | L-altarate = 5-dehydro-4-deoxy-D-glucarate + H2O | L-altarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming) | None | L-talarate hydro-lyase | |
| 4.2.1.157 | (R)-2-hydroxyisocaproyl-CoA dehydratase | False | 2 | 42 | 0 | 2 | (R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O | (R)-2-hydroxy-4-methylpentanoyl-CoA hydro-lyase | None | 2-hydroxyisocaproyl-CoA dehydratase; HadBC | |
| 4.2.1.158 | galactarate dehydratase (D-threo-forming) | False | 1 | 1 | 0 | 1 | galactarate = (2S,3R)-2,3-dihydroxy-5-oxohexanedioate + H2O | galactarate hydro-lyase (3-deoxy-D-threo-hex-2-ulosarate-forming) | None | None | |
| 5.1.1.21 | isoleucine 2-epimerase | False | 1 | 45 | 4 | 3 | L-isoleucine = D-allo-isoleucine | isoleucine 2-epimerase | None | BCAA racemase | |
| 5.1.3.33 | 2-epi-5-epi-valiolone epimerase | False | 1 | 60 | 0 | 1 | 2-epi-5-epi-valiolone = 5-epi-valiolone | 2-epi-5-epi-valiolone 2-epimerase | None | CetB; EVE | |
| 5.1.3.34 | monoglucosyldiacylglycerol epimerase | False | 1 | 10 | 0 | 3 | a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactopyranosyl)-sn-glycerol | 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol 4-epimerase | None | glucolipid epimerase; mgdE (gene name) | |
| 5.1.3.35 | 2-epi-5-epi-valiolone 7-phosphate 2-epimerase | False | 1 | 4 | 0 | 1 | 2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate | 2-epi-5-epi-valiolone-7-phosphate 2-epimerase | None | AcbO | |
| 5.1.99.7 | dihydroneopterin triphosphate 2'-epimerase | False | 5 | 2053 | 0 | 2 | 7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate | 7,8-dihydroneopterin 3'-triphosphate 2'-epimerase | None | D-erythro-7,8-dihydroneopterin triphosphate epimerase; folX (gene name) | |
| 5.3.3.19 | 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase | False | 3 | 16 | 0 | 2 | 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate | 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase | None | BacB | |
| 5.4.1.4 | D-galactarolactone isomerase | False | 1 | 9 | 0 | 1 | D-galactaro-1,5-lactone = D-galactaro-1,4-lactone | D-galactaro-1,5-lactone isomerase (D-galactaro-1,4-lactone-forming) | None | GLI | |
| 5.4.99.63 | ethylmalonyl-CoA mutase | False | 2 | 8 | 0 | 3 | (2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA | (2R)-ethylmalonyl-CoA CoA-carbonylmutase | None | Ecm | |
| 5.5.1.27 | D-galactarolactone cycloisomerase | False | 1 | 123 | 0 | 1 | (1) D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate;;(2) D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate | D-galactaro-1,4-lactone lyase (ring-opening) | None | GCI | |
| 6.2.1.45 | E1 ubiquitin-activating enzyme | False | 18 | 5698 | 40 | 12 | ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine | ubiquitin:[E1 ubiquitin-activating enzyme] ligase (AMP-forming) | None | ubiquitin activating enzyme; E1; ubiquitin-activating enzyme E1 | |
| 6.2.1.46 | L-allo-isoleucine---holo-[CmaA peptidyl-carrier protein] ligase | False | 1 | 1 | 0 | 1 | ATP + L-allo-isoleucine + holo-[CmaA peptidyl-carrier protein] = AMP + diphosphate + L-allo-isoleucyl-[CmaA peptidyl-carrier protein] | L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase (AMP-forming) | None | CmaA | |
| 6.3.2.48 | L-arginine-specific L-amino acid ligase | False | 1 | 31 | 0 | 1 | ATP + L-arginine + an L-amino acid = ADP + phosphate + an L-arginyl-L-amino acid | L-arginine:L-amino acid ligase (ADP-forming) | None | RizA; L-amino acid ligase RizA | |
| 6.3.2.49 | L-alanine---L-anticapsin ligase | False | 3 | 206 | 0 | 11 | ATP + L-alanine + L-anticapsin = ADP + phosphate + bacilysin | L-alanine:L-anticapsin ligase (ADP-forming) | None | BacD; alanine-anticapsin ligase; L-Ala-L-anticapsin ligase; ywfE (gene name) | |
| 1.1.1.389 | 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase | False | 1 | 0 | 0 | 4 | 2-dehydro-3-deoxy-L-galactonate + NAD+ = 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+ | 2-dehydro-3-deoxy-L-galactonate:NAD+ 5-oxidoreductase | None | None | |
| 1.1.1.390 | sulfoquinovose 1-dehydrogenase | False | 1 | 54 | 0 | 1 | sulfoquinovose + NAD+ = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H+ | 6-deoxy-6-sulfo-D-glucopyranose:NAD+ 1-oxidoreductase | None | None | |
| 1.2.1.96 | 4-hydroxybenzaldehyde dehydrogenase (NADP+) | False | 2 | 30 | 0 | 3 | 4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ | 4-hydroxybenzaldehyde:NADP+ oxidoreductase | None | p-hydroxybenzaldehyde dehydrogenase (ambiguous); pchA (gene name) | |
| 1.2.1.97 | 3-sulfolactaldehyde dehydrogenase | False | 3 | 18 | 0 | 2 | (2S)-3-sulfolactaldehyde + NAD(P)+ + H2O = (2S)-3-sulfolactate + NAD(P)H + H+ | (2S)-3-sulfolactaldehyde:NAD(P)+ oxidoreductase | None | SLA dehydrogenase | |
| 1.3.1.108 | caffeoyl-CoA reductase | False | 3 | 536 | 1 | 1 | 3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster | 3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+,ferredoxin oxidoreductase | None | electron-bifurcating caffeoyl-CoA reductase; caffeoyl-CoA reductase-Etf complex; hydrocaffeoyl-CoA:NAD+,ferredoxin oxidoreductase | |
| 1.3.1.109 | butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) | True | 0 | 0 | 0 | 6 | butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster | butanoyl-CoA:NAD+, ferredoxin oxidoreductase | None | bifurcating butyryl-CoA dehydrogenase; butyryl-CoA dehydrogenase/Etf complex; Etf-Bcd complex; bifurcating butanoyl-CoA dehydrogenase; butanoyl-CoA dehydrogenase/Etf complex; butanoyl-CoA dehydrogenase (NAD+, ferredoxin) | |
| 1.6.5.12 | demethylphylloquinone reductase | False | 2 | 38 | 0 | 2 | demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ | NADPH:demethylphylloquinone oxidoreductase | None | ndbB (gene name); NDC1 (gene name); demethylphylloquinone:NADPH oxidoreductase | |
| 1.13.11.81 | 7,8-dihydroneopterin oxygenase | False | 4 | 10 | 0 | 3 | 7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde | 7,8-dihydroneopterin:oxygen oxidoreductase | None | None | |
| 1.13.11.82 | 8'-apo-carotenoid 13,14-cleaving dioxygenase | False | 1 | 6 | 0 | 0 | 8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial | 8'-apo-beta-carotenal:oxygen 13,14-dioxygenase (bond-cleaving) | None | NACOX1 (gene name) | |
| 1.14.11.49 | uridine-5'-phosphate dioxygenase | False | 2 | 0 | 0 | 1 | UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate | UMP,2-oxoglutarate:oxygen oxidoreductase | None | lipL (gene name) | |
| 1.14.12.24 | 2,4-dinitrotoluene dioxygenase | False | 1 | 0 | 0 | 4 | 2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + nitrite + NAD+ | 2,4-dinitrotoluene,NADH:oxygen oxidoreductase (4,5-hydroxylating, nitrite-releasing) | None | dntA (gene name) | |
| 1.14.13.208 | benzoyl-CoA 2,3-epoxidase | False | 2 | 2150 | 0 | 1 | benzoyl-CoA + NADPH + H+ + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP+ + H2O | benzoyl-CoA,NADPH:oxygen oxidoreductase (2,3-epoxydizing) | None | benzoyl-CoA dioxygenase/reductase (incorrect); BoxBA; BoxA/BoxB system; benzoyl-CoA 2,3-dioxygenase (incorrect) | |
| 1.14.13.209 | salicyloyl-CoA 5-hydroxylase | False | 1 | 56 | 0 | 1 | 2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O | salicyloyl-CoA,NADH:oxygen oxidoreductase (5-hydroxylating) | None | sdgC (gene name) | |
| 1.14.14.16 | steroid 21-monooxygenase | False | 9 | 869 | 0 | 7 | a C21 steroid + [reduced NADPH---hemoprotein reductase] + O2 = a 21-hydroxy-C21-steroid + [oxidized NADPH---hemoprotein reductase] + H2O | steroid,NADPH---hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating) | None | steroid 21-hydroxylase; 21-hydroxylase; P450c21; CYP21A2 (gene name) | |
| 1.14.14.17 | squalene monooxygenase | False | 20 | 5510 | 3 | 27 | squalene + [reduced NADPH---hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH---hemoprotein reductase] + H2O | squalene,NADPH---hemoprotein:oxygen oxidoreductase (2,3-epoxidizing) | None | squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase | |
| 1.14.14.18 | heme oxygenase (biliverdin-producing) | False | 53 | 5145 | 11 | 29 | protoheme + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH---hemoprotein reductase] + 3 H2O | protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) | None | ORP33 proteins; haem oxygenase (ambiguous); heme oxygenase (decyclizing) (ambiguous); heme oxidase (ambiguous); haem oxidase (ambiguous); heme oxygenase (ambiguous); heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) | |
| 1.14.14.19 | steroid 17alpha-monooxygenase | False | 24 | 1273 | 10 | 19 | a C21-steroid + [reduced NADPH---hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + [oxidized NADPH---hemoprotein reductase] + H2O;; | steroid,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating) | None | steroid 17alpha-hydroxylase; cytochrome P-450 17alpha; cytochrome P-450 (P-450 17alpha,lyase); 17alpha-hydroxylase-C17,20 lyase; CYP17; CYP17A1 (gene name) | |
| 1.14.15.14 | methyl-branched lipid omega-hydroxylase | False | 3 | 57 | 5 | 1 | a methyl-branched lipid + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = an omega-hydroxy-methyl-branched lipid + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | methyl-branched lipid,reduced-ferredoxin:oxygen oxidoreductase (omega-hydroxylating) | None | CYP124 | |
| 1.14.19.37 | acyl-CoA 5-desaturase | False | 3 | 1 | 0 | 2 | (1) (11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O;;(2) (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O | acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating) | None | acyl-CoA 5-desaturase (non-methylene-interrupted) | |
| 1.14.19.38 | acyl-lipid Delta6-acetylenase | False | 1 | 0 | 0 | 1 | (1) a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) a stearidonoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta6 acyl-lipid,ferrocytochrome-b5:oxygen oxidoreductase (6,7-dehydrogenating) | None | None | |
| 1.14.19.39 | acyl-lipid Delta12-acetylenase | False | 1 | 35 | 0 | 8 | linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = crepenynyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta12 acyl-lipid,ferrocytochrome-b5:oxygen oxidoreductase (12,13-dehydrogenating) | None | None | |
| 1.14.19.40 | hex-5-enoyl-[acyl-carrier protein] acetylenase | False | 1 | 0 | 0 | 1 | hex-5-enoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = hex-5-ynoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | hex-5-enoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (5,6-dehydrogenating) | None | jamB (gene name) | |
| 1.14.19.41 | sterol 22-desaturase | False | 11 | 1599 | 0 | 9 | ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP+ + 2 H2O | ergosta-5,7,24(28)-trien-3beta-ol,NADPH:oxygen oxidoreductase (22,23-dehydrogenating) | None | ERG5 (gene name); CYP710A (gene name) | |
| 1.14.19.42 | palmitoyl-[glycerolipid] 7-desaturase | False | 1 | 4 | 0 | 2 | a 1-acyl-2-palmitoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-acyl-2-palmitoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (7,8-cis-dehydrogenating) | None | FAD5 | |
| 1.14.19.43 | palmitoyl-[glycerolipid] 3-(E)-desaturase | False | 1 | 0 | 0 | 3 | a 1-acyl-2-palmitoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-acyl-2-palmitoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (3,4-trans -dehydrogenating) | None | FAD4 | |
| 1.14.19.44 | acyl-CoA (8-3)-desaturase | False | 8 | 0 | 0 | 8 | (1) (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O;;(2) (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + 2 ferricytochrome b5 + 2 H2O | Delta8-acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6-cis-dehydrogenating) | None | FADS1 (gene name); acyl-CoA 5-desaturase (methylene-interrupted) | |
| 1.14.19.45 | sn-1 oleoyl-lipid 12-desaturase | False | 5 | 8 | 0 | 9 | a 1-oleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-linoleoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-oleoyl-2-acyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (12,13-cis-dehydrogenating) | None | desA (gene name) | |
| 1.14.19.46 | sn-1 linoleoyl-lipid 6-desaturase | False | 2 | 0 | 0 | 2 | a 1-linoleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-gamma-linolenoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | 1-linoleoyl-2-acyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (6,7-cis-dehydrogenating) | None | desD (gene name) | |
| 1.14.19.47 | acyl-lipid (9-3)-desaturase | False | 4 | 0 | 0 | 14 | (1) an alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a stearidonoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) a linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a gamma-linolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O | Delta9 acyl-[glycerolipid],ferrocytochrome b5:oxygen oxidoreductase (6,7-cis-dehydrogenating) | None | DES6 (gene name); acyl-lipid 6-desaturase; acyl-lipid Delta6-desaturase; Delta6-desaturase (ambiguous) | |
| 1.21.99.4 | thyroxine 5'-deiodinase | False | 23 | 2 | 0 | 16 | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating) | None | diiodothyronine 5'-deiodinase [ambiguous]; iodothyronine 5'-deiodinase; iodothyronine outer ring monodeiodinase; type I iodothyronine deiodinase; type II iodothyronine deiodinase; thyroxine 5-deiodinase [misleading]; L-thyroxine iodohydrolase (reducing) | |
| 2.1.1.319 | type I protein arginine methyltransferase | False | 59 | 5168 | 80 | 11 | 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine (overall reaction);;(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine;;(1b) S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming) | None | PRMT1 (gene name); PRMT2 (gene name); PRMT3 (gene name); PRMT4 (gene name); PRMT6 (gene name); PRMT8 (gene name); RMT1 (gene name); CARM1 (gene name) | |
| 2.1.1.320 | type II protein arginine methyltransferase | False | 26 | 7493 | 56 | 9 | 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine (overall reaction);;(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine;;(1b) S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming) | None | PRMT5 (gene name); PRMT9 (gene name) | |
| 2.1.1.321 | type III protein arginine methyltransferase | False | 8 | 1043 | 1 | 5 | S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming) | None | PRMT7 (gene name) | |
| 2.1.1.322 | type IV protein arginine methyltransferase | False | 0 | 9 | 0 | 1 | S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming) | None | RMT2 (gene name) | |
| 2.3.1.251 | lipid IVA palmitoyltransferase | False | 64 | 1460 | 0 | 5 | (1) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A;;(2) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = 2-acyl-sn-glycero-3-phosphocholine + lipid IIB;;(3) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA = 2-acyl-sn-glycero-3-phosphocholine + lipid IVB | 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine:lipid-IVA palmitoyltransferase | None | PagP; crcA (gene name) | |
| 2.4.1.335 | dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase | False | 1 | 22 | 0 | 1 | UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate = UDP + an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate | UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate:dolichyl N-acetyl-alpha-D-glucosaminyl-phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase | None | AglC; UDP-Glc-2,3-diNAcA glycosyltransferase | |
| 2.4.1.336 | monoglucosyldiacylglycerol synthase | False | 3 | 90 | 0 | 5 | UDP-alpha-D-glucose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol | UDP-alpha-D-glucose:1,2-diacyl-sn-glycerol 3-beta-D-glucosyltransferase | None | mgdA (gene name) | |
| 2.4.1.337 | 1,2-diacylglycerol 3-alpha-glucosyltransferase | False | 3 | 95 | 0 | 3 | UDP-alpha-D-glucose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol | UDP-alpha-D-glucose:1,2-diacyl-sn-glycerol 3-alpha-D-glucosyltransferase | None | mgs (gene name); UDP-glucose:diacylglycerol glucosyltransferase; UDP-glucose:1,2-diacylglycerol glucosyltransferase; uridine diphosphoglucose-diacylglycerol glucosyltransferase; UDP-glucose-diacylglycerol glucosyltransferase; UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase; UDP-glucose:1,2-diacyl-sn-glycerol 3-D-glucosyltransferase; 1,2-diacylglycerol 3-glucosyltransferase (ambiguous) | |
| 2.4.99.21 | dolichyl-phosphooligosaccharide-protein glycotransferase | False | 10 | 4145 | 1 | 11 | an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine | dolichyl-phosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase | None | AglB; archaeal oligosaccharyl transferase; dolichyl-monophosphooligosaccharide-protein glycotransferase | |
| 2.5.1.129 | flavin prenyltransferase | False | 38 | 20267 | 12 | 1 | prenyl phosphate + FMNH2 = prenylated FMNH2 + phosphate | prenyl-phosphate:FMNH2 prenyltransferase | None | ubiX (gene name); PAD1 (gene name); dimethylallyl-phosphate:FMNH2 prenyltransferase | |
| 2.5.1.130 | 2-carboxy-1,4-naphthoquinone phytyltransferase | False | 2 | 709 | 0 | 2 | phytyl diphosphate + 2-carboxy-1,4-naphthoquinone = demethylphylloquinone + diphosphate + CO2 | phytyl-diphosphate:2-carboxy-1,4-naphthoquinone phytyltransferase | None | menA (gene name); ABC4 (gene name); 1,4-dioxo-2-naphthoate phytyltransferase; 1,4-diketo-2-naphthoate phytyltransferase | |
| 2.5.1.131 | (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase | False | 2 | 17 | 0 | 1 | [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate | [5-(aminomethyl)furan-3-yl]methyl-diphosphate:gamma-L-glutamyltyramine [5-(aminomethyl)furan-3-yl]methyltransferase | None | MfnF | |
| 2.7.1.190 | aminoglycoside 2''-phosphotransferase | False | 8 | 243 | 0 | 7 | GTP + gentamicin = GDP + gentamicin 2''-phosphate | GTP:gentamicin 2''-O-phosphotransferase | None | aphD (gene name); APH(2''); aminoglycoside (2'') kinase; gentamicin kinase (ambiguous); gentamicin phosphotransferase (ambiguous) | |
| 2.7.4.31 | [5-(aminomethyl)furan-3-yl]methyl phosphate kinase | False | 1 | 23 | 0 | 1 | ATP + [5-(aminomethyl)furan-3-yl]methyl phosphate = ADP + [5-(aminomethyl)furan-3-yl]methyl diphosphate | ATP:[5-(aminomethyl)furan-3-yl]methyl-phosphate phosphotransferase | None | MfnE | |
| 3.5.1.119 | Pup amidohydrolase | False | 4 | 81 | 0 | 4 | [prokaryotic ubiquitin-like protein]-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-L-glutamate + NH3 | [prokaryotic ubiquitin-like protein]-L-glutamine amidohydrolase | None | dop (gene name); Pup deamidase; depupylase/deamidase; DPUP; depupylase | |
| 4.1.1.102 | phenacrylate decarboxylase | False | 4 | 879 | 46 | 9 | (1) 4-coumarate = 4-vinylphenol + CO2;;(2) trans-cinnamate = styrene + CO2;;(3) ferulate = 4-vinylguaiacol + CO2 | 3-phenylprop-2-enoate carboxy-lyase | None | FDC1 (gene name); ferulic acid decarboxylase | |
| 4.2.1.159 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase | False | 4 | 50 | 0 | 6 | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O (overall reaction);;(1a) dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O;;(1b) dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose (spontaneous) | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose hydro-lyase (dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose-forming) | None | jadO (gene name); evaA (gene name); megBVI (gene name); eryBV (gene name); mtmV (gene name); oleV (gene name); spnO (gene name); TDP-4-keto-6-deoxy-D-glucose 2,3-dehydratase; dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose hydro-lyase (dTDP-(2R,6S)-2,4-dihydroxy-6-methyl-2,6-dihydropyran-3-one-forming) | |
| 4.2.1.160 | 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase | True | 0 | 0 | 0 | 1 | 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O | 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase | None | None | |
| 4.2.1.161 | bisanhydrobacterioruberin hydratase | False | 1 | 15 | 0 | 1 | bacterioruberin = bisanhydrobacterioruberin + 2 H2O (overall reaction);; (1a) bacterioruberin = monoanhydrobacterioruberin + H2O;; (1b) monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O | bacterioruberin hydro-lyase (bisanhydrobacterioruberin-forming) | None | CruF; C50 carotenoid 2'',3''-hydratase | |
| 4.2.2.26 | oligo-alginate lyase | False | 2 | 23 | 0 | 7 | Cleavage of poly(4-deoxy-alpha-L-erythro-hexopyranuronoside) oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their non-reducing ends into 4-deoxy-alpha-L-erythro-hex-4-enopyranuronate monosaccharides. | alginate oligosaccharide 4-deoxy-alpha-L-erythro-hex-4-enopyranuronate-(1->4)-hexananopyranuronate lyase | None | aly (gene name) (ambiguous); oalS17 (gene name); oligoalginate lyase; exo-oligoalginate lyase | |
| 4.2.3.153 | (5-formylfuran-3-yl)methyl phosphate synthase | False | 18 | 2713 | 0 | 1 | 2 D-glyceraldehyde 3-phosphate = (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O | D-glyceraldehyde-3-phosphate phosphate-lyase [D-glyceraldehyde-3-phosphate-adding; (5-formylfuran-3-yl)methyl-phosphate-forming] | None | mfnB (gene name); 4-HFC-P synthase; 4-(hydroxymethyl)-2-furaldehyde phosphate synthase | |
| 5.1.3.36 | heparosan-glucuronate 5-epimerase | True | 0 | 0 | 0 | 1 | [heparosan]-D-glucuronate = [acharan]-L-iduronate | [heparosan]-D-glucuronate 5-epimerase | None | HG-5epi | |
| 5.1.3.37 | mannuronan 5-epimerase | False | 12 | 1139 | 5 | 6 | [mannuronan]-beta-D-mannuronate = [alginate]-alpha-L-guluronate | [mannuronan]-beta-D-mannuronate 5-epimerase | None | algG (gene name); alginate epimerase; C5-mannuronan epimerase; mannuronan C-5-epimerase | |
| 5.1.99.8 | 7,8-dihydroneopterin epimerase | False | 18 | 38 | 0 | 4 | 7,8-dihydroneopterin = 7,8-dihydromonapterin | 7,8-dihydroneopterin 2'-epimerase | None | None | |
| 6.3.1.19 | prokaryotic ubiquitin-like protein ligase | False | 78 | 4214 | 0 | 13 | ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine | [prokaryotic ubiquitin-like protein]:[protein]-L-lysine | None | PafA (ambiguous); Pup ligase; proteasome accessory factor A | |
| 1.1.1.391 | 3beta-hydroxycholanate 3-dehydrogenase (NAD+) | False | 2 | 58 | 0 | 3 | isolithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+ | isolithocholate:NAD+ 3-oxidoreductase | None | 3beta-hydroxysteroid dehydrogenase | |
| 1.1.1.392 | 3alpha-hydroxycholanate dehydrogenase (NADP+) | False | 1 | 144 | 0 | 1 | lithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ | lithocholate:NADP+ 3-oxidoreductase | None | alpha-hydroxy-cholanate dehydrogenase (ambiguous) | |
| 1.1.1.393 | 3beta-hydroxycholanate 3-dehydrogenase (NADP+) | False | 1 | 48 | 0 | 1 | isolithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ | isolithocholate:NADP+ 3-oxidoreductase | None | 3beta-hydroxysteroid dehydrogenase (ambiguous) | |
| 1.1.1.394 | aurachin B dehydrogenase | False | 1 | 92 | 0 | 1 | aurachin B + NAD+ + H2O = 4-[(2E,6E)-farnesyl]-4-hydroxy-2-methyl-3-oxo-3,4-dihydroquinoline 1-oxide + NADH + H+ (overall reaction);;(1a) 4-[(2E,6E)-farnesyl]-3,4-dihydroxy-2-methyl-3,4-dihydroquinoline 1-oxide + NAD+ = 4-[(2E,6E)-farnesyl]-4-hydroxy-2-methyl-3-oxo-3,4-dihydroquinoline 1-oxide + NADH + H+;;(1b) aurachin B + H2O = 4-[(2E,6E)-farnesyl]-3,4-dihydroxy-2-methyl-3,4-dihydroquinoline 1-oxide (spontaneous) | aurachin B:NAD+ 3-oxidoreductase | None | AuaH | |
| 1.2.5.3 | aerobic carbon monoxide dehydrogenase | False | 9 | 775 | 1 | 5 | CO + a quinone + H2O = CO2 + a quinol | carbon-monoxide,water:quinone oxidoreductase | None | MoCu-CODH; coxSML (gene names); molybdoenzyme carbon monoxide dehydrogenase | |
| 1.3.1.111 | geranylgeranyl-bacteriochlorophyllide a reductase | False | 0 | 9 | 0 | 5 | bacteriochlorophyll a + 3 NADP+ = geranylgeranyl bacteriochlorophyllide a + 3 NADPH + 3 H+ | bacteriochlorophyll-a:NADP+ oxidoreductase (geranylgeranyl-reducing) | None | geranylgeranyl-bacteriopheophytin reductase; bchP (gene name) | |
| 1.3.7.12 | red chlorophyll catabolite reductase | False | 3 | 10 | 0 | 29 | primary fluorescent chlorophyll catabolite + 2 oxidized ferredoxin [iron-sulfur] cluster = red chlorophyll catabolite + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase | None | RCCR; RCC reductase; red Chl catabolite reductase | |
| 1.14.13.210 | 4-methyl-5-nitrocatechol 5-monooxygenase | False | 1 | 7 | 0 | 2 | 4-methyl-5-nitrocatechol + NAD(P)H + H+ + O2 = 2-hydroxy-5-methylquinone + nitrite + NAD(P)+ + H2O | 4-methyl-5-nitrocatechol,NAD(P)H:oxygen 5-oxidoreductase (5-hydroxylating, nitrite-forming) | None | dntB (gene name); 4-methyl-5-nitrocatechol oxygenase; MNC monooxygenase | |
| 1.14.13.211 | rifampicin monooxygenase | False | 3 | 0 | 0 | 2 | rifampicin + NAD(P)H + O2 = 2-hydroxy-2,27-secorifampicin + NAD(P)+ + H2O | rifampicin:NAD(P)H:oxygen oxidoreductase (2-hydroxy-2,27-secorifampicin-forming; ring-cleaving) | None | RIF-O; ROX; RIFMO; rifampicin:NAD(P)H:oxygen oxidoreductase (2'-N-hydroxyrifampicin-forming) (incorrect) | |
| 1.14.13.212 | 1,3,7-trimethyluric acid 5-monooxygenase | True | 0 | 0 | 0 | 1 | 1,3,7-trimethylurate + NADH + H+ + O2 = 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O | 1,3,7-trimethylurate,NADH:oxygen oxidoreductase (1,3,7-trimethyl-5-hydroxyisourate-forming) | None | tmuM (gene name) | |
| 1.14.13.215 | protoasukamycin 4-monooxygenase | False | 1 | 0 | 0 | 1 | protoasukamycin + NADH + H+ + O2 = 4-hydroxyprotoasukamycin + NAD+ + H2O | protoasukamycin,NADH:oxygen oxidoreductase (4-hydroxylating) | None | None | |
| 1.14.13.216 | asperlicin C monooxygenase | False | 1 | 0 | 0 | 1 | asperlicin C + NAD(P)H + H+ + O2 = asperlicin E + NAD(P)+ + H2O | asperlicin C,NAD(P)H:oxygen oxidoreductase | None | AspB | |
| 1.14.13.217 | protodeoxyviolaceinate monooxygenase | False | 1 | 2 | 0 | 3 | protodeoxyviolaceinate + NAD(P)H + O2 = protoviolaceinate + NAD(P)+ + H2O | protodeoxyviolaceinate,NAD(P)H:O2 oxidoreductase | None | vioD (gene name); protoviolaceinate synthase | |
| 1.14.14.20 | phenol 2-monooxygenase (FADH2) | True | 0 | 0 | 0 | 6 | phenol + FADH2 + O2 = catechol + FAD + H2O | phenol,FADH2:oxygen oxidoreductase (2-hydroxylating) | None | pheA1 (gene name) | |
| 1.14.14.21 | dibenzothiophene monooxygenase | False | 5 | 6475 | 0 | 8 | dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene-5,5-dioxide + 2 FMN + 2 H2O (overall reaction);;(1a) dibenzothiophene + FMNH2 + O2 = dibenzothiophene-5-oxide + FMN + H2O;;(1b) dibenzothiophene-5-oxide + FMNH2 + O2 = dibenzothiophene-5,5-dioxide + FMN + H2O | dibenzothiophene,FMNH2:oxygen oxidoreductase | None | dszC (gene name) | |
| 1.14.14.22 | dibenzothiophene sulfone monooxygenase | False | 3 | 1 | 2 | 7 | dibenzothiophene-5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + H2O + FMN + NAD+ + H+ (overall reaction);;(1a) FMNH2 + O2 = FMN-N5-peroxide;;(1b) dibenzothiophene-5,5-dioxide + FMN-N5-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N5-oxide;;(1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous) | dibenzothiophene-5,5-dioxide,FMNH2:oxygen oxidoreductase | None | dszA (gene name) | |
| 1.14.14.23 | cholesterol 7alpha-monooxygenase | False | 6 | 638 | 0 | 9 | cholesterol + [reduced NADPH---hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH---hemoprotein reductase] + H2O | cholesterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating) | None | cholesterol 7alpha-hydroxylase; CYP7A1 (gene name) | |
| 1.14.14.24 | vitamin D 25-hydroxylase | False | 3 | 1 | 0 | 5 | calciol + O2 + [reduced NADPH---hemoprotein reductase] = calcidiol + [oxidized NADPH---hemoprotein reductase] + H2O | calciol,NADPH---hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) | None | vitamin D2 25-hydroxylase; vitamin D3 25-hydroxylase; CYP2R1 | |
| 1.14.14.25 | cholesterol 24-hydroxylase | False | 2 | 14 | 6 | 16 | cholesterol + [reduced NADPH---hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH---hemoprotein reductase] + H2O | cholesterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating) | None | cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1 | |
| 1.14.14.26 | 24-hydroxycholesterol 7alpha-hydroxylase | False | 9 | 7 | 0 | 3 | (24S)-cholest-5-ene-3beta,24-diol + [reduced NADPH---hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,7alpha,24-triol + [oxidized NADPH---hemoprotein reductase] + H2O | (24S)-cholest-5-ene-3beta,24-diol,NADPH---hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating) | None | 24-hydroxycholesterol 7alpha-monooxygenase; CYP39A1; CYP39A1 oxysterol 7alpha-hydroxylase | |
| 1.14.15.15 | cholestanetriol 26-monooxygenase | False | 5 | 86 | 2 | 7 | 5beta-cholestane-3alpha,7alpha,12alpha-triol + 6 reduced adrenodoxin + 6 H+ + 3 O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 6 oxidized adrenodoxin + 4 H2O (overall reaction);;(1a) 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 oxidized adrenodoxin + H2O;;(1b) (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 oxidized adrenodoxin + 2 H2O;;(1c) (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 oxidized adrenodoxin + H2O | 5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating) | None | 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase; 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxylase; CYP27A; CYP27A1; cytochrome P450 27A1' | |
| 1.14.15.16 | vitamin D3 24-hydroxylase | False | 3 | 3 | 0 | 3 | (1) calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O;;(2) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O | calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) | None | CYP24A1 | |
| 1.14.15.17 | pheophorbide a oxygenase | False | 2 | 71 | 0 | 12 | pheophorbide a + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = red chlorophyll catabolite + 2 oxidized ferredoxin [iron-sulfur] cluster (overall reaction);;(1a) pheophorbide a + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = epoxypheophorbide a + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) epoxypheophorbide a + H2O = red chlorophyll catabolite (spontaneous) | pheophorbide-a,ferredoxin:oxygen oxidoreductase (biladiene-forming) | None | pheide a monooxygenase; pheide a oxygenase; PaO; PAO | |
| 1.17.7.4 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase | False | 441 | 34750 | 0 | 18 | (1) 3-methylbut-3-en-1-yl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+;;(2) prenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | 3-methylbut-3-en-1-yl-diphosphate:ferredoxin oxidoreductase | None | isopentenyl-diphosphate:NADP+ oxidoreductase; LytB; (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HMBPP reductase; IspH; LytB/IspH; isopentenyl-diphosphate:ferredoxin oxidoreductase | |
| 1.21.98.2 | dichlorochromopyrrolate synthase | False | 1 | 22 | 0 | 2 | 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + NH3 + 2 H2O | 3-(7-chloroindol-3-yl)-2-iminopropanoate ammonia-lyase (dichlorochromopyrrolate-forming) | None | RebD; chromopyrrolic acid synthase; chromopyrrolate synthase | |
| 2.1.1.323 | (-)-pluviatolide 4-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin | S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase | None | OMT3 (gene name) | |
| 2.1.1.324 | dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase | False | 1 | 2 | 0 | 1 | 2 S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = 2 S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine (overall reaction);;(1a) S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose;;(1b) S-adenosyl-L-methionine + dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine | S-adenosyl-L-methionine:dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose N,N-dimethyltransferase | None | SpnS; TDP-4-amino-2,3,6-trideoxy-D-glucose N,N-dimethyltransferase | |
| 2.6.1.110 | dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase | False | 1 | 4 | 0 | 1 | dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate | dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose:2-oxoglutarate aminotransferase | None | SpnR; TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase | |
| 2.7.1.191 | protein-Npi-phosphohistidine---D-mannose phosphotransferase | False | 8 | 5516 | 0 | 15 | [protein]-Npi-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-mannose Npi-phosphotransferase | None | manXYZ (gene names); mannose PTS permease; EIIMan; Enzyme IIMan | |
| 2.7.1.192 | protein-Npi-phosphohistidine---N-acetylmuramate phosphotransferase | False | 14 | 1574 | 0 | 2 | [protein]-Npi-phospho-L-histidine + N-acetyl-D-muramate[side 1] = [protein]-L-histidine + N-acetyl-D-muramate 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:N-acetyl-D-muramate Npi-phosphotransferase | None | murP (gene name); N-acetylmuramic acid PTS permease; EIINAcMur; Enzyme IINAcMur | |
| 2.7.1.193 | protein-Npi-phosphohistidine---N-acetyl-D-glucosamine phosphotransferase | False | 4 | 355 | 0 | 5 | [protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1] = [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:N-acetyl-D-glucosamine Npi-phosphotransferase | None | nagE (gene name); N-acetyl-D-glucosamine PTS permease; EIINag; Enzyme IINag; EIICBANag | |
| 2.7.1.194 | protein-Npi-phosphohistidine---L-ascorbate phosphotransferase | False | 12 | 161 | 0 | 28 | [protein]-Npi-phospho-L-histidine + L-ascorbate[side 1] = [protein]-L-histidine + L-ascorbate 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:L-ascorbate Npi-phosphotransferase | None | ulaABC (gene names); L-ascorbate PTS permease; EIISga; Enzyme IISga; Enzyme IIUla | |
| 2.7.1.195 | protein-Npi-phosphohistidine---2-O-alpha-mannosyl-D-glycerate phosphotransferase | False | 1 | 27 | 0 | 1 | [protein]-Npi-phospho-L-histidine + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannopyranosyl)-D-glycerate [side 2] | protein-Npi-phospho-L-histidine:2-O-alpha-mannopyranosyl-D-glycerate Npi-phosphotransferase | None | mngA (gene names); 2-O-alpha-mannosyl-D-glycerate PTS permease; EIIMngA; Enzyme IIMngA; Enzyme IIHrsA; EIImannosylglycerate; Frx | |
| 2.7.1.196 | protein-Npi-phosphohistidine---N,N'-diacetylchitobiose phosphotransferase | False | 3 | 251 | 0 | 2 | [protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1] = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2] | protein-Npi-phospho-L-histidine:N,N'-diacetylchitobiose Npi-phosphotransferase | None | chbABC (gene names); N,N'-diacetylchitobiose PTS permease; chitobiose PTS permease; EIIcel; EIIchb; Enzyme IIcel; Enzyme IIchb | |
| 2.7.1.197 | protein-Npi-phosphohistidine---D-mannitol phosphotransferase | False | 27 | 5344 | 0 | 2 | [protein]-Npi-phospho-L-histidine + D-mannitol[side 1] = [protein]-L-histidine + D-mannitol 1-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-mannitol Npi-phosphotransferase | None | mtlA (gene name); D-mannitol PTS permease; EIIMtl | |
| 2.7.1.198 | protein-Npi-phosphohistidine---D-sorbitol phosphotransferase | False | 3 | 197 | 0 | 2 | [protein]-Npi-phospho-L-histidine + D-sorbitol[side 1] = [protein]-L-histidine + D-sorbitol 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-sorbitol Npi-phosphotransferase | None | srlABE (gene names); D-sorbitol PTS permease; sorbitol PTS permease; glucitol PTS permease; EIIGut; Enzyme IIGut | |
| 2.7.1.199 | protein-Npi-phosphohistidine---D-glucose phosphotransferase | False | 33 | 2175 | 0 | 8 | [protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-glucose Npi-phosphotransferase | None | ptsG (gene name); D-glucose PTS permease; EIIGlc; Enzyme IIGlc | |
| 2.7.1.200 | protein-Npi-phosphohistidine---galactitol phosphotransferase | False | 4 | 158 | 0 | 1 | [protein]-Npi-phospho-L-histidine + galactitol[side 1] = [protein]-L-histidine + galactitol 1-phosphate[side 2] | protein-Npi-phospho-L-histidine:galactitol Npi-phosphotransferase | None | gatABC (gene names); galactitol PTS permease; EIIGat; Enzyme IIGat | |
| 2.7.1.201 | protein-Npi-phosphohistidine---trehalose phosphotransferase | False | 2 | 1507 | 0 | 2 | [protein]-Npi-phospho-L-histidine + alpha,alpha-trehalose[side 1] = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:alpha,alpha-trehalose Npi-phosphotransferase | None | treB (gene name); trehalose PTS permease; EIITre; Enzyme IITre | |
| 2.7.1.202 | protein-Npi-phosphohistidine---D-fructose phosphotransferase | False | 25 | 10586 | 0 | 9 | [protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 1-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-fructose Npi-phosphotransferase | None | fruAB (gene names); fructose PTS permease; EIIFru; Enzyme IIFru | |
| 2.7.1.203 | protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase | False | 0 | 2 | 0 | 1 | [protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:2-amino-2-deoxy-D-gluconate Npi-phosphotransferase | None | dgaABCD (gene names); 2-amino-2-deoxy-D-gluconate PTS permease | |
| 2.7.1.204 | protein-Npi-phosphohistidine---D-galactose phosphotransferase | False | 1 | 0 | 0 | 2 | [protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2] | protein-Npi-phospho-L-histidine:D-galactose Npi-phosphotransferase | None | D-galactose PTS permease; EIIGal; Enzyme IIGal | |
| 2.7.1.205 | protein-Npi-phosphohistidine---cellobiose phosphotransferase | False | 4 | 172 | 0 | 5 | [protein]-Npi-phospho-L-histidine + cellobiose[side 1] = [protein]-L-histidine + 6-phospho-beta-D-glucosyl-(1->4)-D-glucose[side 2] | protein-Npi-phospho-L-histidine:cellobiose Npi-phosphotransferase | None | celB (gene name); cellobiose PTS permease; EIICel; Enzyme IICel | |
| 2.7.1.206 | protein-Npi-phosphohistidine---L-sorbose phosphotransferase | False | 2 | 39 | 0 | 2 | [protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2] | protein-Npi-phospho-L-histidine:L-sorbose Npi-phosphotransferase | None | sorABFM (gene names); L-sorbose PTS permease; EIISor; Enzyme IISor | |
| 2.7.1.207 | protein-Npi-phosphohistidine---lactose phosphotransferase | False | 13 | 1225 | 0 | 6 | [protein]-Npi-phospho-L-histidine + lactose[side 1] = [protein]-L-histidine + lactose 6'-phosphate[side 2] | protein-Npi-phospho-L-histidine:lactose Npi-phosphotransferase | None | lacEF (gene names); lactose PTS permease; EIILac; Enzyme IILac | |
| 2.7.1.208 | protein-Npi-phosphohistidine---maltose phosphotransferase | False | 2 | 9 | 0 | 3 | [protein]-Npi-phospho-L-histidine + maltose[side 1] = [protein]-L-histidine + maltose 6'-phosphate[side 2] | protein-Npi-phospho-L-histidine:maltose Npi-phosphotransferase | None | malT (gene name); maltose PTS permease; EIIMal; Enzyme IIMal | |
| 3.1.1.99 | 6-deoxy-6-sulfogluconolactonase | False | 1 | 345 | 0 | 1 | 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate | 6-deoxy-6-sulfo-D-glucono-1,5-lactone lactonohydrolase | None | SGL lactonase | |
| 3.1.3.99 | IMP-specific 5'-nucleotidase | False | 27 | 2403 | 2 | 2 | IMP + H2O = inosine + phosphate | inosine 5'-phosphate phosphohydrolase | None | ISN1 (gene name) | |
| 3.1.3.100 | thiamine phosphate phosphatase | False | 2 | 7 | 0 | 7 | thiamine phosphate + H2O = thiamine + phosphate | thiamine phosphate phosphohydrolase | None | None | |
| 3.2.1.196 | limit dextrin alpha-1,6-maltotetraose-hydrolase | False | 62 | 1341 | 0 | 5 | Hydrolysis of (1->6)-alpha-D-glucosidic linkages to branches with degrees of polymerization of three or four glucose residues in limit dextrin. | glycogen phosphorylase-limit dextrin maltotetraose-hydrolase | None | glgX (gene name); glycogen debranching enzyme (ambiguous) | |
| 3.7.1.23 | maleylpyruvate hydrolase | False | 1 | 0 | 0 | 2 | 3-maleylpyruvate + H2O = maleate + pyruvate | (2Z)-4,6-dioxohept-2-enedioate acylhydrolase | None | hbzF (gene name) | |
| 3.9.1.3 | phosphohistidine phosphatase | False | 6 | 695 | 0 | 9 | a [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate | [protein]-N-phospho-L-histidine phosphohydrolase | None | PHPT1 (gene name); protein histidine phosphatase; PHP | |
| 4.1.2.58 | 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase | False | 1 | 43 | 0 | 1 | 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate | 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate (2S)-3-sulfolactaldehyde-lyase (pyruvate-forming) | None | KDSG aldolase | |
| 4.2.1.162 | 6-deoxy-6-sulfo-D-gluconate dehydratase | False | 1 | 71 | 0 | 1 | 6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O | 6-deoxy-6-sulfo-D-gluconate hydro-lyase (2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate-forming) | None | SG dehydratase | |
| 4.2.1.163 | 2-oxo-hept-4-ene-1,7-dioate hydratase | False | 1 | 113 | 0 | 1 | (4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate | (4S)-4-hydroxy-2-oxoheptanedioate hydro-lyase [(4Z)-2-oxohept-4-enedioate-forming] | None | HpcG | |
| 4.2.99.23 | tuliposide B-converting enzyme | False | 1 | 0 | 0 | 1 | 6-tuliposide B = tulipalin B + D-glucose | 6-tuliposide B D-glucose-lyase (tulipalin B-forming) | None | None | |
| 6.3.1.20 | lipoate---protein ligase | False | 81 | 11345 | 4 | 13 | ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction) ;;(1a) ATP + (R)-lipoate = lipoyl-AMP + diphosphate;;(1b) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP | [lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming) | None | lplA (gene name); lplJ (gene name); lipoate protein ligase; lipoate-protein ligase A; LPL; LPL-B | |
| 1.1.1.395 | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase | False | 2 | 61 | 0 | 1 | a 3alpha-hydroxy bile acid CoA ester + NAD+ = a 3-oxo bile acid CoA ester + NADH + H+ | 3alpha-hydroxy-bile-acid-CoA-ester:NAD+ 3-oxidoreductase | None | baiA1 (gene name); baiA2 (gene name); baiA3 (gene name) | |
| 1.1.1.396 | bacteriochlorophyllide a dehydrogenase | False | 0 | 1 | 0 | 3 | (1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+;;(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+ | 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming) | None | bchC (gene name) | |
| 1.1.1.397 | beta-methylindole-3-pyruvate reductase | False | 1 | 0 | 0 | 1 | (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+ | (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase | None | ind2 (gene name) | |
| 1.1.1.398 | 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase | False | 1 | 0 | 0 | 1 | 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + 2 NAD+ + H2O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + 2 NADH + 2 H+ (overall reaction);;(1a) 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + NAD+ = 2-(glutathion-S-yl)-2-methylbut-3-enal + NADH + H+;;(1b) 2-(glutathion-S-yl)-2-methylbut-3-enal + NAD+ + H2O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + NADH + H+ | 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol:NAD+ oxidoreductase | None | isoH (gene name); 4-hydroxy-3-glutathionyl-3-methylbut-1-ene dehydrogenase | |
| 1.1.1.399 | 2-oxoglutarate reductase | False | 22 | 12954 | 0 | 14 | (R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+ | (R)-2-hydroxyglutarate:NAD+ 2-oxidireductase | None | serA (gene name) | |
| 1.1.1.400 | 2-methyl-1,2-propanediol dehydrogenase | False | 1 | 29 | 0 | 2 | 2-methylpropane-1,2-diol + NAD+ = 2-hydroxy-2-methylpropanal + NADH + H+ | 2-methylpropane-1,2-diol:NAD+ 1-oxidoreductase | None | mpdB (gene name) | |
| 1.1.1.401 | 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) | False | 2 | 99 | 0 | 4 | 2-dehydro-3-deoxy-L-rhamnonate + NAD+ = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ | 2-dehydro-3-deoxy-L-rhamnonate:NAD+ 4-oxidoreductase | None | 2-keto-3-deoxy-L-rhamnonate dehydrogenase | |
| 1.1.1.402 | D-erythritol 1-phosphate dehydrogenase | False | 1 | 10 | 0 | 3 | D-erythritol 1-phosphate + NADP+ = D-erythrulose 1-phosphate + NADPH + H+ | D-erythritol-1-phosphate 2-oxidoreductase | None | eryB (gene name) | |
| 1.1.1.403 | D-threitol dehydrogenase (NAD+) | False | 1 | 10 | 0 | 2 | D-threitol + NAD+ = D-erythrulose + NADH + H+ | D-threitol:NAD+ oxidoreductase | None | dthD (gene name) | |
| 1.1.2.9 | 1-butanol dehydrogenase (cytochrome c) | False | 1 | 0 | 0 | 1 | butan-1-ol + 2 ferricytochrome c = butanal + 2 ferrocytochrome c + 2 H+ | butan-1-ol:ferricytochrome c oxidoreductase | None | BDH | |
| 1.1.5.11 | 1-butanol dehydrogenase (quinone) | False | 1 | 1 | 0 | 2 | butan-1-ol + a quinone = butanal + a quinol | butan-1-ol:quinone oxidoreductase | None | BOH | |
| 1.2.1.98 | 2-hydroxy-2-methylpropanal dehydrogenase | False | 1 | 5 | 0 | 1 | 2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxy-2-methylpropanoate + NADH + H+ | 2-hydroxy-2-methylpropanal:NAD+ oxidoreductase | None | mpdC (gene name) | |
| 1.2.3.15 | (methyl)glyoxal oxidase | False | 1 | 26 | 0 | 4 | (1) glyoxal + H2O + O2 = glyoxylate + H2O2;;(2) 2-oxopropanal + H2O + O2 = pyruvate + H2O2 | (methyl)glyoxal:oxygen oxidoreductase | None | glx1 (gene name); glx2 (gene name) | |
| 1.3.3.15 | coproporphyrinogen III oxidase (coproporphyrin-forming) | False | 7 | 9921 | 0 | 2 | coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2 | coproporphyrinogen-III:oxygen oxidoreductase (coproporphyrin-forming) | None | hemY (gene name) | |
| 1.3.7.13 | 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) | True | 0 | 0 | 0 | 9 | protochlorophyllide a + 2 oxidized ferredoxin [iron-sulfur] cluster = 3,8-divinyl protochlorophyllide a + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | protochlorophyllide-a:ferredoxin C-81-oxidoreductase | None | bciB (gene name); cyano-type divinyl chlorophyllide a 8-vinyl-reductase | |
| 1.3.7.14 | 3,8-divinyl chlorophyllide a reductase | False | 0 | 2 | 0 | 1 | bacteriochlorophyllide g + 2 oxidized ferredoxin [iron-sulfur] cluster + ADP + phosphate = 3,8-divinyl chlorophyllide a + 2 reduced ferredoxin [iron-sulfur] cluster + ATP + H2O + 2 H+ | bacteriochlorophyllide-g:ferredoxin C-81-oxidoreductase | None | None | |
| 1.3.7.15 | chlorophyllide a reductase | False | 10 | 1659 | 0 | 9 | (1) 3-deacetyl-3-vinylbacteriochlorophyllide a + 2 oxidized ferredoxin [iron-sulfur] cluster + ADP + phosphate = chlorophyllide a + 2 reduced ferredoxin [iron-sulfur] cluster + ATP + H2O + 2 H+;;(2) bacteriochlorophyllide a + 2 oxidized ferredoxin [iron-sulfur] cluster + ADP + phosphate = 3-acetyl-3-devinylchlorophyllide a + 2 reduced ferredoxin [iron-sulfur] cluster + ATP + H2O + 2 H+;;(3) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + 2 oxidized ferredoxin [iron-sulfur] cluster + ADP + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + 2 reduced ferredoxin [iron-sulfur] cluster + ATP + H2O + 2 H+;; | bacteriochlorophyllide-a:ferredoxin 7,8-oxidoreductase | None | bchX (gene name); bchY (gene name); bchZ (gene name); COR | |
| 1.3.98.3 | coproporphyrinogen dehydrogenase | False | 16 | 18218 | 0 | 12 | coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine | coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating) | None | oxygen-independent coproporphyrinogen-III oxidase; HemN; coproporphyrinogen III oxidase | |
| 1.7.2.7 | hydrazine synthase | False | 2 | 35 | 0 | 6 | hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c | hydrazine:ferricytochrome-c oxidoreductase | None | HZS | |
| 1.7.2.8 | hydrazine dehydrogenase | False | 1 | 7 | 1 | 7 | hydrazine + 4 ferricytochrome c = N2 + 4 ferrocytochrome c | hydrazine:ferricytochrome c oxidoreductase | None | HDH | |
| 1.14.11.51 | DNA N6-methyladenine demethylase | False | 10 | 11 | 6 | 4 | N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2 | DNA-N6-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | None | ALKBH1 | |
| 1.14.11.52 | validamycin A dioxygenase | False | 1 | 28 | 0 | 1 | validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2 | validamycin-A,2-oxoglutarate:oxygen oxidoreductase (6'-hydroxylating) | None | vldW (gene name) | |
| 1.14.11.53 | mRNA N6-methyladenine demethylase | False | 15 | 2137 | 3 | 3 | N6-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2 | mRNA-N6-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | None | ALKBH5; FTO | |
| 1.14.13.218 | 5-methylphenazine-1-carboxylate 1-monooxygenase | False | 2 | 24 | 0 | 1 | 5-methylphenazine-1-carboxylate + NADH + O2 = pyocyanin + NAD+ + CO2 + H2O | 5-methylphenazine-1-carboxylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | None | phzS (gene name) | |
| 1.14.13.219 | resorcinol 4-hydroxylase (NADPH) | False | 1 | 0 | 0 | 1 | resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O | resorcinol,NADPH:oxygen oxidoreductase (4-hydroxylating) | None | None | |
| 1.14.13.220 | resorcinol 4-hydroxylase (NADH) | False | 1 | 17 | 0 | 1 | resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O | resorcinol,NADH:oxygen oxidoreductase (4-hydroxylating) | None | tsdB (gene name) | |
| 1.14.14.27 | resorcinol 4-hydroxylase (FADH2) | False | 1 | 0 | 0 | 2 | resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O | resorcinol,FADH2:oxygen oxidoreductase (4-hydroxylating) | None | graA (gene name) | |
| 1.14.14.28 | long-chain alkane monooxygenase | False | 1 | 5 | 0 | 3 | a long-chain alkane + FMNH2 + O2 = a long-chain primary alcohol + FMN + H2O | long-chain-alkane,FMNH2:oxygen oxidoreductase | None | None | |
| 1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase | False | 3 | 0 | 0 | 5 | (1) cholest-5-ene-3beta,25-diol + [reduced NADPH---hemoprotein reductase] + O2 = cholest-5-ene-3beta,7alpha,25-triol + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) (25R)-cholest-5-ene-3beta,26-diol + [reduced NADPH---hemoprotein reductase] + O2 = (25R)-cholest-5-ene-3beta,7alpha,26-triol + [oxidized NADPH---hemoprotein reductase] + H2O | cholest-5-ene-3beta,25/26-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) | None | 25-hydroxycholesterol 7alpha-monooxygenase; CYP7B1; CYP7B1 oxysterol 7alpha-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7alpha-hydroxylase; cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating); 25-hydroxycholesterol 7alpha-hydroxylase | |
| 1.14.15.18 | calcidiol 1-monooxygenase | False | 3 | 5 | 0 | 12 | (1) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O;;(2) secalciferol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O | calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating) | None | 25-hydroxycholecalciferol 1-hydroxylase; 25-hydroxycholecalciferol 1-monooxygenase; 1-hydroxylase-25-hydroxyvitamin D3; 25-hydroxy D3-1alpha-hydroxylase; 25-hydroxycholecalciferol 1alpha-hydroxylase; 25-hydroxyvitamin D3 1alpha-hydroxylase | |
| 1.14.15.19 | C-19 steroid 1alpha-hydroxylase | False | 1 | 0 | 0 | 1 | testosterone + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 1alpha-hydroxytestosterone + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | testosterone,reduced-ferredoxin:oxygen oxidoreductase (1alpha-hydroxylating) | None | CYP260A1 | |
| 1.14.15.20 | heme oxygenase (biliverdin-producing, ferredoxin) | False | 0 | 2 | 0 | 18 | protoheme + 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ = biliverdin + Fe2+ + CO + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O | protoheme,reduced ferredoxin:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) | None | HO1 (gene name); HY1 (gene name); HO3 (gene name); HO4 (gene name); pbsA1 (gene name) | |
| 2.1.1.325 | juvenile hormone-III synthase | False | 3 | 2 | 0 | 27 | (1) S-adenosyl-L-methionine + (2E,6E)-farnesoate = S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate;; (2) S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III | S-adenosyl-L-methionine:(2E,6E)-farnesoate O-methyltransferase | None | farnesoic acid methyltransferase; juvenile hormone acid methyltransferase; JHAMT | |
| 2.1.1.326 | N-acetyldemethylphosphinothricin P-methyltransferase | True | 0 | 0 | 0 | 4 | 2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor | S-adenosyl-L-methionine:N-acetyldemethylphosphinothricin P-methyltransferase | None | phpK (gene name); bcpD (gene name); P-methylase | |
| 2.3.1.252 | mycolipanoate synthase | False | 1 | 6 | 0 | 1 | a long-chain acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + 6 H+ + holo-[mycolipanoate synthase] = mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O | long-chain acyl-CoA:(S)-methylmalonyl-CoA C-acyltransferase (mycolipanoate-forming) | None | msl3 (gene name); Pks3/4; mycolipanoic acid synthase; long-chain acyl-CoA:methylmalonyl-CoA C-acyltransferase (mycolipanoate-forming) | |
| 2.4.1.338 | validoxylamine A glucosyltransferase | False | 2 | 15 | 0 | 1 | UDP-alpha-D-glucose + validoxylamine A = UDP + validamycin A | UDP-alpha-D-glucose:validoxylamine-A 4'-O-glucosyltransferase | None | vldK (gene name); valG (gene name) | |
| 2.4.1.339 | beta-1,2-mannobiose phosphorylase | False | 2 | 5 | 4 | 2 | beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = D-mannopyranose + alpha-D-mannose 1-phosphate | beta-D-mannopyranosyl-(1->2)-D-mannopyranose:phosphate alpha-D-mannosyltransferase | None | None | |
| 2.4.1.340 | 1,2-beta-oligomannan phosphorylase | False | 1 | 5 | 0 | 1 | [(1->2)-beta-D-mannosyl]n + phosphate = [(1->2)-beta-D-mannosyl]n-1 + alpha-D-mannose 1-phosphate | (1->2)-beta-D-mannan:phosphate beta-D-mannosyl transferase (configuration-inverting) | None | None | |
| 2.4.1.341 | alpha-1,2-colitosyltransferase | False | 1 | 0 | 0 | 1 | GDP-beta-L-colitose + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = GDP + alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine | GDP-beta-L-colitose:beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine L-colitosyltransferase (configuration-inverting) | None | wbgN (gene name) | |
| 2.4.2.58 | hydroxyproline O-arabinosyltransferase | False | 7 | 0 | 0 | 4 | UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline = UDP + [protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline | UDP-beta-L-arabinofuranose:[protein]-trans-4-hydroxy-L-proline L-arabinofuranosyl transferase (configuration-retaining) | None | HPAT | |
| 2.5.1.132 | 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase | False | 0 | 1 | 0 | 5 | phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate | phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase | None | 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase; 2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase; Kdn 9-P synthase | |
| 2.7.1.209 | L-erythrulose 1-kinase | False | 2 | 15 | 0 | 1 | ATP + L-erythrulose = ADP + L-erythrulose 1-phosphate | ATP:L-erythrulose 1-phosphotransferase | None | lerK (gene name); L-erythrulose 1-kinase [incorrect] | |
| 2.7.1.210 | D-erythrulose 4-kinase | False | 1 | 21 | 0 | 1 | ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate | ATP:D-erythrulose 4-phosphotransferase | None | derK (gene name) | |
| 2.8.3.24 | (R)-2-hydroxy-4-methylpentanoate CoA-transferase | True | 0 | 0 | 0 | 1 | 4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA | 4-methylpentanoyl-CoA:(R)-2-hydroxy-4-methylpentanoate CoA-transferase | None | hadA (gene name) | |
| 3.1.3.101 | validoxylamine A 7'-phosphate phosphatase | False | 1 | 23 | 0 | 1 | validoxylamine A 7'-phosphate + H2O = validoxylamine A + phosphate | validoxylamine-A 7'-phosphate phosphohydrolase | None | vldH (gene name) | |
| 3.1.3.102 | FMN hydrolase | False | 2 | 31 | 0 | 6 | FMN + H2O = riboflavin + phosphate | FMN phosphohydrolase | None | FMN phosphatase; AtcpFHy1 | |
| 3.3.2.15 | trans-2,3-dihydro-3-hydroxyanthranilic acid synthase | False | 3 | 7 | 0 | 3 | (2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate | (2S)-2-amino-4-deoxychorismate pyruvate-hydrolase | None | isochorismatase (ambiguous); phzD (gene name) | |
| 3.5.4.42 | N-isopropylammelide isopropylaminohydrolase | False | 1 | 294 | 1 | 16 | N-isopropylammelide + H2O = cyanuric acid + isopropylamine | N-isopropylammelide isopropylaminohydrolase | None | atzC (gene name) | |
| 4.2.1.164 | dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase | False | 1 | 11 | 0 | 1 | dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose hydro-lyase (dTDP-2,3,6-trideoxy-alpha-D-hexopyranose-forming) | None | SpnQ; TDP-4-keto-2,6-dideoxy-D-glucose 3-dehydrase | |
| 4.2.1.165 | chlorophyllide a 31-hydratase | False | 0 | 1 | 0 | 6 | (1) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O;;(2) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O | chlorophyllide-a 31-hydro-lyase | None | bchF (gene name) | |
| 4.2.1.166 | phosphinomethylmalate isomerase | False | 1 | 0 | 0 | 1 | 2-(hydroxyphosphonoylmethyl)malate = 3-(hydroxyphosphonoylmethyl)malate (overall reaction);;(1a) 2-(hydroxyphosphonoylmethyl)malate = 2-(phosphinatomethylidene)butanedioate + H2O;;(1b) 2-(phosphinatomethylidene)butanedioate + H2O = 3-(hydroxyphosphonoylmethyl)malate | 2-(phosphinomethyl)malate hydro-lyase [3-(phosphinomethyl)malate-forming] | None | pmi (gene name) | |
| 4.2.1.167 | (R)-2-hydroxyglutaryl-CoA dehydratase | False | 2 | 13 | 0 | 1 | (R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O | (R)-2-hydroxyglutaryl-CoA hydro-lyase ((E)-glutaconyl-CoA-forming) | None | hgdAB (gene names) | |
| 4.2.3.154 | demethyl-4-deoxygadusol synthase | False | 2 | 0 | 0 | 2 | D-sedoheptulose 7-phosphate = demethyl-4-deoxygadusol + phosphate + H2O | D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; demethyl-4-deoxygadusol-forming) | None | Nos2 (gene name); Anb2 (gene name) | |
| 4.2.3.155 | 2-epi-valiolone synthase | False | 2 | 2 | 0 | 2 | D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate | D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; 2-epi-valiolone-forming) | None | None | |
| 4.3.1.31 | L-tryptophan ammonia lyase | True | 0 | 0 | 0 | 1 | L-tryptophan = 3-indoleacrylate + NH3 | L-tryptophan ammonia-lyase (3-indoleacrylate-forming) | None | WAL | |
| 4.99.1.9 | coproporphyrin ferrochelatase | False | 87 | 8751 | 6 | 4 | Fe-coproporphyrin III + 2 H+ = coproporphyrin III + Fe2+ | protoheme ferro-lyase (protoporphyrin-forming) | None | hemH (gene name) | |
| 5.1.3.38 | D-erythrulose 1-phosphate 3-epimerase | False | 1 | 1 | 0 | 3 | D-erythrulose 1-phosphate = L-erythrulose 1-phosphate | D-erythrulose-1-phosphate 3-epimerase | None | eryC (gene name) | |
| 5.3.1.33 | L-erythrulose-1-phosphate isomerase | False | 10 | 94 | 0 | 1 | L-erythrulose 1-phosphate = D-erythrulose 4-phosphate | L-erythrulose-1-phosphate isomerase | None | eryH (gene name) | |
| 5.3.1.34 | D-erythrulose 4-phosphate isomerase | False | 5 | 27 | 0 | 2 | D-erythrulose-4-phosphate = D-erythrose 4-phosphate | D-erythrulose-4-phosphate ketose-aldose isomerase | None | eryI (gene name) | |
| 1.3.1.112 | anthocyanidin reductase [(2S)-flavan-3-ol-forming] | False | 3 | 2 | 0 | 1 | (1) a (2S,3R)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+;;(2) a (2S,3S)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+ | (2S)-flavan-3-ol:NAD(P)+ oxidoreductase | None | None | |
| 1.14.11.54 | mRNA N1-methyladenine demethylase | False | 4 | 9 | 0 | 3 | N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2 | mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | None | ALKBH3 | |
| 1.14.13.222 | aurachin C monooxygenase/isomerase | False | 1 | 30 | 0 | 3 | aurachin C + NAD(P)H + H+ + O2 = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(P)+ + H2O (overall reaction);;(1a) aurachin C + NAD(P)H + H+ + O2 = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one + NAD(P)+ + H2O;;(1b) 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide | aurachin C:NAD(P)H:oxygen oxidoreductase (4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide-forming) | None | auaG (gene name); aurachin C monooxygenase | |
| 1.14.13.223 | 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase | False | 1 | 0 | 0 | 1 | 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + NADH + H+ + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + NAD+ + H2O | 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein],NADH:oxygen oxidoreductase (5-hydroxylating) | None | sibG (gene name) | |
| 1.14.13.224 | violacein synthase | False | 1 | 1 | 0 | 1 | (1) protoviolaceinate + NAD(P)H + O2 = violaceinate + NAD(P)+ + H2O;;(2) protodeoxyviolaceinate + NAD(P)H + O2 = deoxyviolaceinate + NAD(P)+ + H2O | protoviolaceinate,NAD(P)H:O2 oxidoreductase | None | proviolaceinate monooxygenase; vioC (gene name) | |
| 1.14.13.225 | F-actin monooxygenase | False | 17 | 5747 | 2 | 3 | [F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O | [F-actin]-L-methionine,NADPH:O2 S-oxidoreductase | None | MICAL (gene name) | |
| 1.14.13.226 | acetone monooxygenase (methyl acetate-forming) | False | 1 | 0 | 0 | 1 | acetone + NADPH + H+ + O2 = methyl acetate + NADP+ + H2O | acetone,NADPH:oxygen oxidoreductase (methyl acetate-forming) | None | acmA (gene name) | |
| 1.14.13.227 | propane 2-monooxygenase | False | 8 | 1371 | 0 | 3 | propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O | propane,NADH:oxygen oxidoreductase (2-hydroxylating) | None | prmABCD (gene names) | |
| 1.14.14.30 | isobutylamine N-monooxygenase | False | 1 | 3 | 0 | 1 | (1) 2-methylpropan-1-amine + FADH2 + O2 = N-(2-methylpropyl)hydroxylamine + FAD + H2O;;(2) 2-methylpropan-1-amine + FMNH2 + O2 = N-(2-methylpropyl)hydroxylamine + FMN + H2O | 2-methylpropan-1-amine,FADH2:O2 N-oxidoreductase | None | vlmH (gene name) | |
| 1.14.14.31 | ipsdienol synthase | True | 0 | 0 | 0 | 2 | myrcene + [reduced NADPH---hemoprotein reductase] + O2 = (R)-ipsdienol + [oxidized NADPH---hemoprotein reductase] + H2O | myrcene,NADPH---hemoprotein reductase:O2 oxidoreductase (hydroxylating) | None | myrcene hydroxylase; CYP9T2; CYP9T3 | |
| 1.14.14.32 | 17alpha-hydroxyprogesterone deacetylase | False | 24 | 1260 | 0 | 23 | (1) 17alpha-hydroxyprogesterone + [reduced NADPH---hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) 17alpha-hydroxypregnenolone + [reduced NADPH---hemoprotein reductase] + O2 = 3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH---hemoprotein reductase] + H2O | 17alpha-hydroxyprogesterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing) | None | C-17/C-20 lyase; 17alpha-hydroxyprogesterone acetaldehyde-lyase; CYP17; CYP17A1 (gene name); 17alpha-hydroxyprogesterone 17,20-lyase | |
| 1.17.8.1 | hydroxysqualene dehydroxylase | False | 3 | 383 | 0 | 2 | squalene + FAD + H2O = hydroxysqualene + FADH2 | squalene:FAD oxidoreductase (hydroxylating) | None | hpnE (gene name) | |
| 2.1.1.327 | phenazine-1-carboxylate N-methyltransferase | False | 1 | 4 | 0 | 1 | S-adenosyl-L-methionine + phenazine-1-carboxylate = S-adenosyl-L-homocysteine + 5-methylphenazine-1-carboxylate | S-adenosyl-L-methionine:phenazine-1-carboxylate 5-methyltransferase | None | phzM (gene name) | |
| 2.1.1.328 | N-demethylindolmycin N-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + N-demethylindolmycin = S-adenosyl-L-homocysteine + indolmycin | S-adenosyl-L-methionine:N-demethylindolmycin N-methyltransferase | None | ind7 (gene name) | |
| 2.5.1.133 | bacteriochlorophyll a synthase | False | 0 | 5 | 0 | 7 | geranylgeranyl diphosphate + bacteriochlorophyllide a = geranylgeranyl-bacteriochlorophyllide a + diphosphate | geranylgeranyl-diphosphate:bacteriochlorophyllide-a geranylgeranytransferase | None | bchG (gene name) | |
| 2.5.1.134 | cystathionine beta-synthase (O-acetyl-L-serine) | False | 1 | 60 | 0 | 2 | O-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate | O-acetyl-L-serine:L-homocysteine 2-amino-2-carboxyethyltransferase | None | MccB; O-acetylserine dependent cystathionine beta-synthase | |
| 2.7.1.211 | protein-Npi-phosphohistidine---sucrose phosphotransferase | False | 9 | 1570 | 0 | 8 | [protein]-Npi-phospho-L-histidine + sucrose[side 1] = [protein]-L-histidine + sucrose 6G-phosphate[side 2] | protein-Npi-phospho-L-histidine:sucrose Npi-phosphotransferase | None | scrAB (gene names); sucrose PTS permease; EIIScr; Enzyme IIScr | |
| 2.7.1.212 | alpha-D-ribose-1-phosphate 5-kinase (ADP) | False | 1 | 11 | 0 | 1 | ADP + alpha-D-ribose-1-phosphate = AMP + alpha-D-ribose 1,5-bisphosphate | ADP:alpha-D-ribose-1-phosphate 5-phosphotransferase | None | None | |
| 2.7.1.213 | cytidine kinase | False | 3 | 4 | 0 | 2 | ATP + cytidine = ADP + CMP | ATP:cytidine 5'-phosphotransferase | None | None | |
| 2.7.1.214 | C7-cyclitol 7-kinase | False | 2 | 0 | 0 | 2 | (1) ATP + valienone = ADP + valienone 7-phosphate;;(2) ATP + validone = ADP + validone 7-phosphate | ATP:C7-cyclitol 7-phosphotransferase | None | valC (gene name); vldC (gene name) | |
| 2.7.1.215 | erythritol kinase (D-erythritol 1-phosphate-forming) | False | 1 | 9 | 0 | 2 | ATP + erythritol = ADP + D-erythritol 1-phosphate | ATP:erythritol 1-phosphotransferase | None | eryA (gene name) | |
| 2.7.7.91 | valienol-1-phosphate guanylyltransferase | False | 2 | 1 | 0 | 1 | GTP + valienol 1-phosphate = diphosphate + GDP-valienol | GTP:valienol 1-phosphate guanylyltransferase | None | vldB (gene name) | |
| 2.7.7.92 | 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase | False | 0 | 3 | 0 | 4 | CTP + 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate = diphosphate + CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate | CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase | None | None | |
| 2.7.7.93 | phosphonoformate cytidylyltransferase | False | 1 | 0 | 0 | 1 | CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate | CTP:phosphonoformate cytidylyltransferase | None | phpF (gene name) | |
| 2.8.3.25 | bile acid CoA-transferase | False | 2 | 47 | 0 | 0 | (1) lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA;;(2) deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA | lithocholoyl-CoA:cholate CoA-transferase | None | baiF (gene name); baiK (gene name); bile acid coenzyme A transferase | |
| 3.1.1.100 | chlorophyllide a hydrolase | True | 0 | 0 | 0 | 1 | chlorophyllide a + H2O = 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d + methanol + CO2 | chlorophyllide-a hydrolase | None | bciC (gene name) | |
| 3.1.1.101 | poly(ethylene terephthalate) hydrolase | False | 10 | 713 | 48 | 22 | (ethylene terephthalate)n + H2O = (ethylene terephthalate)n-1 + 4-[(2-hydroxyethoxy)carbonyl]benzoate | poly(ethylene terephthalate) hydrolase | None | PETase; PET hydrolase | |
| 3.1.1.102 | mono(ethylene terephthalate) hydrolase | False | 1 | 61 | 10 | 2 | 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = terephthalate + ethylene glycol | 4-[(2-hydroxyethoxy)carbonyl]benzoate acylhydrolase | None | MHET hydrolase; MHETase | |
| 3.1.2.32 | 2-aminobenzoylacetyl-CoA thioesterase | False | 1 | 5 | 7 | 1 | (2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA | (2-aminobenzoyl)acetyl-CoA hydrolase | None | pqsE (gene name) | |
| 3.1.3.103 | 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase | False | 1 | 3 | 0 | 1 | 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate | 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphohydrolase | None | 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase | |
| 3.1.3.104 | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase | False | 9 | 871 | 0 | 3 | 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphohydrolase | None | 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate phosphatase | |
| 3.2.1.197 | beta-1,2-mannosidase | True | 0 | 0 | 0 | 3 | beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-D-mannopyranose + H2O = beta-D-mannopyranosyl-(1->2)-D-mannopyranose + alpha-D-mannopyranose | beta-1,2-D-mannoside mannohydrolase | None | None | |
| 3.2.1.198 | alpha-mannan endo-1,2-alpha-mannanase | True | 0 | 0 | 0 | 2 | Hydrolysis of the terminal alpha-D-mannosyl-(1->3)-alpha-D-mannose disaccharide from alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl side chains in fungal cell wall alpha-mannans. | alpha-mannan 1,2-[alpha-D-mannosyl-(1->3)-alpha-D-mannose] hydrolase | None | None | |
| 3.2.1.199 | sulfoquinovosidase | False | 1 | 71 | 1 | 2 | a 6-sulfo-alpha-D-quinovosyl diacylglycerol + H2O = 6-sulfo-alpha-D-quinovose + a 1,2-diacylglycerol | 6-sulfo-alpha-D-quinovosyl diacylglycerol 6-sulfo-D-quinovohydrolase (configuration-retaining) | None | yihQ (gene name); 6-sulfo-alpha-D-quinovosyl diacylglycerol 6-sulfo-D-quinovohydrolase | |
| 3.5.4.43 | hydroxydechloroatrazine ethylaminohydrolase | False | 1 | 340 | 0 | 17 | hydroxyatrazine + H2O = N-isopropylammelide + ethylamine | hydroxyatrazine ethylaminohydrolase | None | atzB (gene name); 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase | |
| 4.1.1.103 | gamma-resorcylate decarboxylase | False | 4 | 2 | 0 | 5 | 2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 | 2,6-dihydroxybenzoate carboxy-lyase | None | graF (gene name); tsdA (gene name) | |
| 4.1.99.22 | GTP 3',8-cyclase | False | 275 | 33016 | 0 | 8 | GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor | GTP 3',8-cyclase [(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate-forming] | None | MOCS1A (gene name); moaA (gene name); cnx2 (gene name) | |
| 4.2.1.168 | GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase | False | 2 | 29 | 0 | 2 | GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + 2-oxoglutarate + NH3 (overall reaction);;(1a) GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] + 2-oxoglutarate + H2O;;(1b) 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] = 2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] (spontaneous);;(1c) GDP-2-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH3 (spontaneous) | GDP-4-dehydro-alpha-D-rhamnose 3-hydro-lyase | None | colD (gene name) | |
| 4.2.3.156 | hydroxysqualene synthase | False | 3 | 28 | 0 | 3 | presqualene diphosphate + H2O = hydroxysqualene + diphosphate | presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming) | None | hpnC (gene name) | |
| 4.4.1.34 | isoprene-epoxide---glutathione S-transferase | False | 1 | 0 | 0 | 1 | 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione | 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol lyase [(3R)-3,4-epoxy-3-methylbut-1-ene-forming] | None | isoI (gene name) | |
| 4.6.1.17 | cyclic pyranopterin monophosphate synthase | False | 371 | 29679 | 1 | 5 | (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate | (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate lyase (cyclic pyranopterin phosphate-forming) | None | MOCS1B (gene name); moaC (gene name); cnx3 (gene name) | |
| 6.2.1.47 | medium-chain-fatty-acid---[acyl-carrier-protein] ligase | False | 11 | 178 | 0 | 1 | ATP + a medium-chain fatty acid + a holo-[acyl-carrier protein] = AMP + diphosphate + a medium-chain acyl-[acyl-carrier protein] | medium-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming) | None | jamA (gene name) | |
| 1.5.3.23 | glyphosate oxidoreductase | True | 0 | 0 | 0 | 5 | 2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate | glyphosate oxidoreductase (aminomethylphosphonate-forming) | None | gox (gene name) | |
| 1.8.5.5 | thiosulfate reductase (quinone) | False | 1 | 61 | 0 | 1 | sulfite + hydrogen sulfide + a quinone = thiosulfate + a quinol | sulfite,hydrogen sulfide:quinone oxidoreductase | None | phsABC (gene names) | |
| 1.8.5.6 | sulfite dehydrogenase (quinone) | False | 1 | 38 | 0 | 2 | sulfite + a quinone + H2O = sulfate + a quinol | sulfite:quinone oxidoreductase | None | soeABC (gene name) | |
| 1.10.3.16 | dihydrophenazinedicarboxylate synthase | False | 3 | 2 | 0 | 3 | (1) (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2;;(2) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2;;(3) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2;;(4) (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-5,10-dihydrophenazine-1-carboxylate + H2O2 | 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate:oxygen oxidoreductase | None | phzG (gene name) | |
| 1.14.12.25 | p-cumate 2,3-dioxygenase | False | 1 | 10 | 0 | 2 | p-cumate + NADH + H+ + O2 = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ | 4-isopropylbenzoate:oxygen 2,3-oxidoreductase | None | None | |
| 1.14.13.228 | jasmonic acid 12-hydroxylase | False | 1 | 0 | 0 | 1 | (-)-jasmonate + NADPH + H+ + O2 = trans-12-hydroxyjasmonate + NADP+ + H2O | jasmonate,NADPH:oxygen oxidoreductase (12-hydroxylating) | None | ABM (gene name) | |
| 1.14.13.229 | tert-butyl alcohol monooxygenase | False | 1 | 0 | 0 | 4 | tert-butyl alcohol + NADPH + H+ + O2 = 2-methylpropane-1,2-diol + NADP+ + H2O | tert-butyl alcohol,NADPH:oxygen oxidoreductase | None | mdpJK (gene names); tert-butanol monooxygenase | |
| 1.14.13.230 | butane monooxygenase (soluble) | True | 0 | 0 | 0 | 1 | butane + NADH + H+ + O2 = butan-1-ol + NAD+ + H2O | butane,NADH:oxygen oxidoreductase | None | sBMO; bmoBCDXYZ (gene names) | |
| 1.14.13.231 | tetracycline 11a-monooxygenase | False | 4 | 8 | 0 | 4 | tetracycline + NADPH + H+ + O2 = 11a-hydroxytetracycline + NADP+ + H2O | tetracycline,NADPH:oxygen oxidoreductase (11a-hydroxylating) | None | tetX (gene name) | |
| 1.14.13.232 | 6-methylpretetramide 4-monooxygenase | False | 2 | 52 | 0 | 1 | 6-methylpretetramide + NADPH + H+ + O2 = 4-hydroxy-6-methylpretetramide + NADP+ + H2O | 6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating) | None | None | |
| 1.14.13.233 | 4-hydroxy-6-methylpretetramide 12a-monooxygenase | False | 1 | 0 | 0 | 1 | 4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 = 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O | 4-hydroxy-6-methylpretetramide,NADPH:oxygen oxidoreductase (12a-hydroxylating) | None | oxyL (gene name) | |
| 1.14.13.234 | 5a,11a-dehydrotetracycline 5-monooxygenase | False | 1 | 10 | 0 | 2 | 5a,11a-dehydrotetracycline + NADPH + H+ + O2 = 5a,11a-dehydrooxytetracycline + NADP+ + H2O | 5a,11a-dehydrotetracycline,NADPH:oxygen oxidoreductase (5-hydroxylating) | None | oxyS (gene name); 12-dehydrotetracycline 5-monooxygenase | |
| 1.14.14.33 | ethylenediaminetetraacetate monooxygenase | True | 0 | 0 | 0 | 3 | ethylenediaminetetraacetate + 2 FMNH2 + 2 O2 = ethylenediamine-N,N'-diacetate + 2 glyoxylate + 2 FMN + 2 H2O (overall reaction);;(1a) ethylenediaminetetraacetate + FMNH2 + O2 = ethylenediaminetriacetate + glyoxylate + FMN + H2O;;(1b) ethylenediaminetriacetate + FMNH2 + O2 = ethylenediamine-N,N'-diacetate + glyoxylate + FMN + H2O | ethylenediaminetetraacetate,FMNH2:O2 oxidoreductase (glyoxylate-forming) | None | None | |
| 1.14.14.34 | methanesulfonate monooxygenase (FMNH2) | True | 0 | 0 | 0 | 3 | methanesulfonate + FMNH2 + O2 = formaldehyde + FMN + sulfite + H2O | methanesulfonate,FMNH2:oxygen oxidoreductase | None | msuD (gene name); ssuD (gene name) | |
| 1.14.14.35 | dimethylsulfone monooxygenase | False | 2 | 47 | 0 | 2 | dimethyl sulfone + FMNH2 + O2 = methanesulfinate + formaldehyde + FMN + H2O | dimethyl sulfone,FMNH2:oxygen oxidoreductase | None | sfnG (gene name) | |
| 1.14.14.36 | tyrosine N-monooxygenase | False | 1 | 3 | 0 | 3 | L-tyrosine + 2 O2 + 2 [reduced NADPH---hemoprotein reductase] = (E)-[4-hydroxyphenylacetaldehyde oxime] + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) L-tyrosine + O2 + [reduced NADPH---hemoprotein reductase] = N-hydroxy-L-tyrosine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) N-hydroxy-L-tyrosine + O2 + [reduced NADPH---hemoprotein reductase] = N,N-dihydroxy-L-tyrosine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) N,N-dihydroxy-L-tyrosine = (E)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O | L-tyrosine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | tyrosine N-hydroxylase; CYP79A1 | |
| 1.14.14.37 | 4-hydroxyphenylacetaldehyde oxime monooxygenase | False | 1 | 12 | 0 | 2 | (E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime;;(1b) (Z)-4-hydroxyphenylacetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O;;(1c) 4-hydroxyphenylacetonitrile + [reduced NADPH---hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH---hemoprotein reductase] + H2O | (E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | 4-hydroxybenzeneacetaldehyde oxime monooxygenase; cytochrome P450II-dependent monooxygenase; NADPH-cytochrome P450 reductase (CYP71E1); CYP71E1; 4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase | |
| 1.14.15.21 | zeaxanthin epoxidase | False | 8 | 630 | 0 | 58 | zeaxanthin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = violaxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (overall reaction);;(1a) zeaxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = antheraxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) antheraxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = violaxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | zeaxanthin,reduced ferredoxin:oxygen oxidoreductase | None | Zea-epoxidase | |
| 1.14.15.22 | vitamin D 1,25-hydroxylase | False | 1 | 3 | 0 | 1 | (1) calciol + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(2) calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | calciol,ferredoxin:oxygen oxidoreductase (1,25-hydroxylating) | None | CYP105A1; Streptomyces griseolus cytochrome P450SU-1 | |
| 1.14.19.48 | tert-amyl alcohol desaturase | False | 1 | 0 | 0 | 3 | tert-amyl alcohol + NADPH + H+ + O2 = isoprenyl alcohol + NADP+ + 2 H2O | tert-amyl alcohol,NADPH:oxygen oxidoreductase (1,2-dehydrogenating) | None | mdpJK (gene names) | |
| 1.14.19.49 | tetracycline 7-halogenase | False | 1 | 7 | 3 | 1 | tetracycline + FADH2 + chloride + O2 + H+ = 7-chlorotetracycline + FAD + 2 H2O | tetracycline:FADH2 oxidoreductase (7-halogenating) | None | ctcP (gene name) | |
| 1.14.19.50 | noroxomaritidine synthase | False | 5 | 821 | 0 | 1 | (1) 4'-O-methylnorbelladine + [reduced NADPH---hemoprotein reductase] + O2 = (4aR,10bS)-noroxomaritidine + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(2) 4'-O-methylnorbelladine + [reduced NADPH---hemoprotein reductase] + O2 = (4aS,10bR)-noroxomaritidine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | 4'-O-methylnorbelladine,NADPH---hemoprotein reductase:oxygen oxidoreductase (noroxomaritidine-forming) | None | CYP96T1 (gene name) | |
| 1.17.3.4 | juglone 3-hydroxylase | True | 0 | 0 | 0 | 1 | 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone (overall reaction);;(1a) 2 juglone + 2 H2O = 2 naphthalene-1,2,4,8-tetrol;;(1b) 2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H2O | 5-hydroxy-1,4-naphthoquinone,water:oxygen oxidoreductase (3-hydroxylating) | None | juglone hydroxylase; naphthoquinone hydroxylase; naphthoquinone-hydroxylase | |
| 1.17.98.2 | bacteriochlorophyllide c C-71-hydroxylase | False | 1 | 7 | 0 | 1 | 2 S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a bacteriochlorophyllide e + 2 5'-deoxyadenosine + 2 L-methionine (overall reaction);;(1a) S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a 7-(hydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine;;(1b) S-adenosyl-L-methionine + a 7-(hydroxymethyl)bacteriochlorophyllide c + H2O = a 7-(dihydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine;;(1c) a 7-(dihydroxymethyl)bacteriochlorophyllide c = a bacteriochlorophyllide e + H2O (spontaneous) | bacteriochlorophyllide-c:S-adenosyl-L-methionine oxidoreductase (C-71-hydroxylating) | None | bciD (gene name) | |
| 1.19.1.1 | flavodoxin---NADP+ reductase | False | 6 | 5653 | 0 | 7 | reduced flavodoxin + NADP+ = oxidized flavodoxin + NADPH + H+ | flavodoxin:NADP+ oxidoreductase | None | FPR | |
| 1.21.98.3 | anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase | False | 4 | 103 | 0 | 11 | magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine (overall reaction);;(1a) magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine + H2O = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-deoxyadenosine + L-methionine;;(1b) 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-deoxyadenosine + L-methionine;;(1c) 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + L-methionine | magnesium-protoporphyrin-IX 13-monomethyl ester,S-adenosyl-L-methionine:H2O oxidoreductase (hydroxylating) | None | bchE (gene name); MPE cyclase (ambiguous) | |
| 2.1.1.329 | demethylphylloquinol methyltransferase | False | 8 | 1067 | 0 | 2 | S-adenosyl-L-methionine + demethylphylloquinol = S-adenosyl-L-homocysteine + phylloquinol | S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinol C-methyltransferase | None | menG (gene name); 2-phytyl-1,4-naphthoquinol methyltransferase | |
| 2.1.1.330 | 5'-demethylyatein 5'-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + (-)-5'-demethylyatein = S-adenosyl-L-homocysteine + (-)-yatein | S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase | None | OMT1 (gene name) | |
| 2.1.1.331 | bacteriochlorophyllide d C-121-methyltransferase | False | 1 | 15 | 0 | 1 | S-adenosyl-L-methionine + 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d = S-adenosyl-L-homocysteine + 8,12-diethyl-3-vinylbacteriochlorophyllide d | S-adenosyl-L-methionine:8-ethyl-12-methyl-3-vinylbacteriochlorophyllide-d C-121-methyltransferase | None | bchR (gene name) | |
| 2.1.1.332 | bacteriochlorophyllide d C-82-methyltransferase | False | 1 | 5 | 0 | 1 | (1) S-adenosyl-L-methionine + 8,12-diethyl-3-vinylbacteriochlorophyllide d = S-adenosyl-L-homocysteine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d;;(2) S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d = S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d | S-adenosyl-L-methionine:8,12-diethyl-3-vinylbacteriochlorophyllide-d C-82-methyltransferase | None | bchQ (gene name) | |
| 2.1.1.333 | bacteriochlorophyllide d C-20 methyltransferase | False | 1 | 0 | 0 | 2 | S-adenosyl-L-methionine + a bacteriochlorophyllide d = S-adenosyl-L-homocysteine + a bacteriochlorophyllide c | S-adenosyl-L-methionine:bacteriochlorophyllide-d C-20 methyltransferase | None | bchU (gene name) | |
| 2.1.1.334 | methanethiol S-methyltransferase | False | 6 | 2993 | 0 | 13 | S-adenosyl-L-methionine + methanethiol = S-adenosyl-L-homocysteine + dimethyl sulfide | S-adenosyl-L-methionine:methanethiol S-methyltransferase | None | mddA (gene name) | |
| 2.1.1.335 | 4-amino-anhydrotetracycline N4-methyltransferase | False | 1 | 14 | 0 | 1 | (1) S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline;;(2) S-adenosyl-L-methionine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + anhydrotetracycline | S-adenosyl-L-methionine:(4S,4aS,12aS)-4-amino-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide Nalpha-methyltransferase | None | oxyT (gene name); ctcO (gene name) | |
| 2.1.1.336 | norbelladine O-methyltransferase | False | 6 | 52 | 5 | 6 | S-adenosyl-L-methionine + norbelladine = S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine | S-adenosyl-L-methionine:norbelladine O-methyltransferase | None | N4OMT1 (gene name) | |
| 2.3.1.253 | phloroglucinol synthase | False | 2 | 0 | 0 | 1 | 3 malonyl-CoA = phloroglucinol + 3 CO2 + 3 CoA | malonyl-CoA:malonyl-CoA malonyltransferase (decarboxylating, phloroglucinol-forming) | None | phlD (gene name) | |
| 2.3.1.254 | N-terminal methionine Nalpha-acetyltransferase NatB | False | 9 | 1707 | 5 | 6 | (1) acetyl-CoA + an N-terminal L-methionyl-L-asparaginyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA;;(2) acetyl-CoA + an N-terminal L-methionyl-L-glutaminyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA;;(3) acetyl-CoA + an N-terminal L-methionyl-L-aspartyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-aspartyl-[protein] + CoA;;(4) acetyl-CoA + an N-terminal L-methionyl-L-glutamyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutamyl-[protein] + CoA;; | acetyl-CoA:N-terminal Met-Asn/Gln/Asp/Glu-[protein] Met-Nalpha-acetyltransferase | None | NAA20 (gene name); NAA25 (gene name) | |
| 2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA | False | 20 | 2125 | 8 | 13 | (1) acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA;;(2) acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA;;(3) acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA;;(4) acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA;;(5) acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA;;(6) acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA | acetyl-CoA:N-terminal-Gly/Ala/Ser/Val/Cys/Thr-[protein] Nalpha-acetyltransferase | None | NAA10 (gene name); NAA15 (gene name); ARD1 (gene name) | |
| 2.3.1.256 | N-terminal methionine Nalpha-acetyltransferase NatC | False | 7 | 49 | 7 | 6 | (1) acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA;;(2) acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA;;(3) acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA;;(4) acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA;;(5) acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA | acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nalpha-acetyltransferase | None | NAA30 (gene name); NAA35 (gene name); NAA38 (gene name); MAK3 (gene name); MAK10 (gene name); MAK31 (gene name) | |
| 2.3.1.257 | N-terminal L-serine Nalpha-acetyltransferase NatD | False | 6 | 3479 | 2 | 2 | (1) acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA;;(2) acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA | acetyl-CoA:N-terminal-L-seryl-[histone 4/2A] L-serine Nalpha-acetyltransferase | None | NAA40 (gene name) | |
| 2.3.1.258 | N-terminal methionine Nalpha-acetyltransferase NatE | False | 13 | 2034 | 9 | 5 | (1) acetyl-CoA + an N-terminal-L-methionyl-L-alanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-alanyl-[protein] + CoA;;(2) acetyl-CoA + an N-terminal-L-methionyl-L-seryl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-seryl-[protein] + CoA;;(3) acetyl-CoA + an N-terminal-L-methionyl-L-valyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-valyl-[protein] + CoA;;(4) acetyl-CoA + an N-terminal-L-methionyl-L-threonyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-threonyl-[protein] + CoA;;(5) acetyl-CoA + an N-terminal-L-methionyl-L-lysyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-lysyl-[protein] + CoA;;(6) acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA;;(7) acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA;;(8) acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA;; | acetyl-CoA:N-terminal-Met-Ala/Ser/Val/Thr/Lys/Leu/Phe/Tyr-[protein] Met-Nalpha-acetyltransferase | None | NAA50 (gene name); NAT5; SAN | |
| 2.3.1.259 | N-terminal methionine Nalpha-acetyltransferase NatF | False | 7 | 2247 | 0 | 1 | acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein] + CoA | acetyl-CoA:N-terminal-Met-Lys/Ser/Val/Leu/Gln/Ile/Tyr/Thr-[transmembrane protein] Met-Nalpha-acetyltransferase | None | NAA60 (gene name) | |
| 2.3.1.260 | tetracycline polyketide synthase | False | 0 | 4 | 0 | 2 | malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO2 + 8 CoA | malonyl-CoA:malonamoyl-[OxyC acyl-carrier protein] malonyltransferase | None | None | |
| 2.3.2.29 | aspartate/glutamate leucyltransferase | False | 191 | 10542 | 0 | 1 | (1) L-leucyl-tRNALeu + N-terminal L-glutamyl-[protein] = tRNALeu + N-terminal L-leucyl-L-glutamyl-[protein];;(2) L-leucyl-tRNALeu + N-terminal L-aspartyl-[protein] = tRNALeu + N-terminal L-leucyl-L-aspartyl-[protein] | L-leucyl-tRNALeu:[protein] N-terminal L-glutamate/L-aspartate leucyltransferase | None | leucylD,E-transferase; bpt (gene name) | |
| 2.3.3.17 | methylthioalkylmalate synthase | False | 3 | 3 | 0 | 3 | an omega-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-[omega-(methylsulfanyl)alkyl]malate + CoA | acetyl-CoA:omega-(methylsulfanyl)-2-oxoalkanoate C-acetyltransferase | None | MAM1 (gene name); MAM3 (gene name); acetyl-CoA:omega-(methylthio)-2-oxoalkanoate C-acetyltransferase | |
| 2.4.1.342 | alpha-maltose-1-phosphate synthase | False | 3 | 87 | 1 | 2 | ADP-alpha-D-glucose + alpha-D-glucose-1-phosphate = ADP + alpha-maltose-1-phosphate | ADP-alpha-D-glucose:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (configuration-retaining) | None | glgM (gene name) | |
| 2.5.1.135 | validamine 7-phosphate valienyltransferase | False | 2 | 1 | 2 | 1 | GDP-valienol + validamine 7-phosphate = validoxylamine A 7'-phosphate + GDP | GDP-valienol:validamine 7-phosphate valienyltransferase | None | vldE (gene name); valL (gene name) | |
| 2.7.7.96 | ADP-D-ribose pyrophosphorylase | False | 4 | 3 | 0 | 1 | ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose | ATP:D-ribose 5-phosphate adenylyltransferase | None | NUDIX5; NUDT5 (gene name); diphosphate---ADP-D-ribose adenylyltransferase; diphosphate adenylyltransferase (ambiguous) | |
| 2.7.7.97 | 3-hydroxy-4-methylanthranilate adenylyltransferase | False | 2 | 0 | 0 | 5 | ATP + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | ATP:3-hydroxy-4-methylanthranilate adenylyltransferase | None | acmA (gene name); sibE (gene name); actinomycin synthase I; 4-MHA-activating enzyme; ACMS I; actinomycin synthetase I; 4-MHA pentapeptide lactone synthase AcmA | |
| 2.7.8.43 | lipid A phosphoethanolamine transferase | False | 0 | 10 | 0 | 13 | (1) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate);;(2) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate);;(3) diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) | diacylphosphatidylethanolamine:lipid-A ethanolaminephosphotransferase | None | lipid A PEA transferase; LptA | |
| 2.7.8.44 | teichoic acid glycerol-phosphate primase | False | 3 | 7 | 0 | 2 | CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-glycerol:N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase | None | Tag primase; CDP-glycerol:glycerophosphate glycerophosphotransferase; tagB (gene name); tarB (gene name) | |
| 3.4.19.15 | desampylase | False | 2 | 26 | 0 | 1 | an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O = a [protein]-L-lysine + a small archaeal modifier protein | N6-[small archaeal modifier protein]-[protein]-L-lysine hydrolase | None | SAMP-protein conjugate cleaving protease; HvJAMM1 | |
| 3.5.1.121 | protein N-terminal asparagine amidohydrolase | False | 4 | 13 | 0 | 5 | N-terminal L-asparaginyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + NH3 | protein N-terminal asparagine amidohydrolase | None | NTAN1 (gene name) | |
| 3.5.1.122 | protein N-terminal glutamine amidohydrolase | False | 23 | 2418 | 5 | 7 | N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3 | protein N-terminal glutamine amidohydrolase | None | NTAQ1 (gene name) | |
| 3.5.1.123 | gamma-glutamylanilide hydrolase | True | 0 | 0 | 0 | 1 | N5-phenyl-L-glutamine + H2O = L-glutamate + aniline | N5-phenyl-L-glutamine amidohydrolase | None | atdA2 (gene name) | |
| 3.5.1.124 | protein deglycase | False | 56 | 1816 | 5 | 5 | (1) an Nomega-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O = a [protein]-L-arginine + lactate;;(2) an N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O = a [protein]-L-lysine + lactate;;(3) an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O = a [protein]-L-cysteine + lactate | a [protein]-L-amino acid-1-hydroxypropan-2-one hydrolase [(R)-lactate-forming] | None | PARK7 (gene name); DJ-1 protein; yhbO (gene name); yajL (gene name); glyoxylase III (incorrect) | |
| 3.6.1.68 | geranyl diphosphate phosphohydrolase | False | 6 | 773 | 2 | 2 | geranyl diphosphate + H2O = geranyl phosphate + phosphate | geranyl-diphosphate phosphohydrolase | None | NUDX1 (gene name) | |
| 4.2.1.169 | 3-vinyl bacteriochlorophyllide d 31-hydratase | True | 0 | 0 | 0 | 1 | a 3-(1-hydroxyethyl) bacteriochlorophyllide d = a 3-vinyl bacteriochlorophyllide d + H2O | 3-vinylbacteriochlorophyllide-d 31-hydro-lyase | None | bchV (gene name) | |
| 4.2.1.170 | 2-(omega-methylthio)alkylmalate dehydratase | False | 3 | 0 | 0 | 1 | (1) a 2-[(omega-methylsulfanyl)alkyl]malate = a 2-[(omega-methylsulfanyl)alkyl]maleate + H2O;;(2) a 3-[(omega-methylsulfanyl)alkyl]malate = a 2-[(omega-methylsulfanyl)alkyl]maleate + H2O | 2-[(omega-methylsulfanyl)alkyl]malate hydro-lyase (2-[(omega-methylsulfanyl)alkyl]maleate-forming) | None | IPMI (gene name); 2-[(omega-methylthio)alkyl]malate hydro-lyase (2-[(omega-methylthio)alkyl]maleate-forming) | |
| 1.1.99.42 | 4-pyridoxic acid dehydrogenase | False | 1 | 2 | 0 | 3 | 4-pyridoxate + acceptor = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced acceptor | 4-pyridoxate:acceptor 5-oxidoreductase | None | mlr6792 (locus name) | |
| 1.1.1.404 | tetrachlorobenzoquinone reductase | False | 1 | 5 | 0 | 1 | 2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ | 2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase | None | pcpD (gene name); TCBQ reductase | |
| 1.1.1.405 | ribitol-5-phosphate 2-dehydrogenase (NADP+) | False | 6 | 616 | 2 | 3 | D-ribitol 5-phosphate + NADP+ = D-ribulose 5-phosphate + NADPH + H+ | D-ribitol-5-phosphate:NADP+ 2-oxidoreductase | None | acs1 (gene name); bcs1 (gene name); tarJ (gene name); ribulose-5-phosphate reductase; ribulose-5-P reductase; D-ribulose 5-phosphate reductase | |
| 1.1.1.406 | galactitol 2-dehydrogenase (L-tagatose-forming) | False | 1 | 0 | 0 | 2 | galactitol + NAD+ = L-tagatose + NADH + H+ | galactitol:NAD+ 2-oxidoreductase (L-tagatose-forming) | None | GatDH | |
| 1.1.1.407 | D-altritol 5-dehydrogenase | False | 1 | 15 | 0 | 1 | D-altritol + NAD+ = D-tagatose + NADH + H+ | D-altritol:NAD+ 5-oxidoreductase | None | None | |
| 1.1.5.12 | D-lactate dehydrogenase (quinone) | False | 3 | 3322 | 0 | 3 | (R)-lactate + a quinone = pyruvate + a quinol | (R)-lactate:quinone 2-oxidoreductase | None | dld (gene name) | |
| 1.1.98.6 | ribonucleoside-triphosphate reductase (formate) | False | 4 | 195 | 0 | 4 | ribonucleoside 5'-triphosphate + formate = 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O | ribonucleoside-5'-triphosphate:formate 2'-oxidoreductase | None | nrdD (gene name); class III ribonucleoside-triphosphate reductase; anaerobic ribonucleotide reductase; anaerobic ribonucleoside-triphosphate reductase | |
| 1.1.99.40 | (R)-2-hydroxyglutarate---pyruvate transhydrogenase | False | 2 | 80 | 0 | 1 | (R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate | (R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming] | None | DLD3 (gene name) | |
| 1.3.8.13 | crotonobetainyl-CoA reductase | False | 44 | 688 | 0 | 2 | gamma-butyrobetainyl-CoA + electron-transfer flavoprotein = crotonobetainyl-CoA + reduced electron-transfer flavoprotein | gamma-butyrobetainyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | None | caiA (gene name) | |
| 1.3.99.38 | menaquinone-9 beta-reductase | False | 3 | 24 | 0 | 2 | menaquinone-9 + reduced acceptor = beta-dihydromenaquinone-9 + acceptor | menaquinone-9 oxidoreductase (beta-dihydromenaquinone-9-forming) | None | MenJ | |
| 1.4.1.25 | L-arginine dehydrogenase | False | 1 | 50 | 0 | 1 | L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ | L-arginine:NAD(P)+ oxidoreductase (deaminating) | None | dauB (gene name); anabolic L-arginine dehydrogenase | |
| 1.4.1.26 | 2,4-diaminopentanoate dehydrogenase (NAD+) | False | 1 | 65 | 0 | 0 | (2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ | (2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating) | None | DAPDH (ambiguous) | |
| 1.4.3.25 | L-arginine oxidase | False | 3 | 0 | 0 | 5 | L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2 | L-arginine:oxygen oxidoreductase (deaminating) | None | None | |
| 1.5.1.51 | N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase | False | 1 | 20 | 0 | 1 | N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O = 2-oxoglutarate + L-2,3-diaminopropanoate + NADH + H+ | N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming) | None | SbnB | |
| 1.8.2.5 | thiosulfate reductase (cytochrome) | False | 0 | 67 | 0 | 5 | sulfite + hydrogen sulfide + 2 ferricytochrome c3 = thiosulfate + 2 ferrocytochrome c3 | sulfite,hydrogen sulfide:ferricytochrome-c3 oxidoreductase (thiosulfate-forming) | None | None | |
| 1.8.5.7 | glutathionyl-hydroquinone reductase | False | 2 | 216 | 0 | 5 | glutathione + 2-(glutathione-S-yl)-hydroquinone = glutathione disulfide + hydroquinone | 2-(glutathione-S-yl)-hydroquinone:glutathione oxidoreductase | None | pcpF (gene name); yqjG (gene name) | |
| 1.14.11.55 | ectoine hydroxylase | False | 10 | 2903 | 0 | 12 | ectoine + 2-oxoglutarate + O2 = 5-hydroxyectoine + succinate + CO2 | ectoine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) | None | ectD (gene name); ectoine dioxygenase | |
| 1.14.11.56 | L-proline cis-4-hydroxylase | False | 2 | 1 | 0 | 2 | L-proline + 2-oxoglutarate + O2 = cis-4-hydroxy-L-proline + succinate + CO2 | L-proline,2-oxoglutarate:oxygen oxidoreductase (cis-4-hydroxylating) | None | None | |
| 1.14.11.57 | L-proline trans-4-hydroxylase | False | 1 | 7 | 0 | 2 | L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2 | L-proline,2-oxoglutarate:oxygen oxidoreductase (trans-4-hydroxylating) | None | None | |
| 1.14.14.38 | valine N-monooxygenase | False | 4 | 6 | 0 | 2 | L-valine + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (E)-2-methylpropanal oxime + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) L-valine + [reduced NADPH---hemoprotein reductase] + O2 = N-hydroxy-L-valine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) N-hydroxy-L-valine + [reduced NADPH---hemoprotein reductase] + O2 = N,N-dihydroxy-L-valine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O | L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | CYP79D1; CYP79D2 | |
| 1.14.14.39 | isoleucine N-monooxygenase | False | 4 | 19 | 0 | 2 | L-isoleucine + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (1E,2S)-2-methylbutanal oxime + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) L-isoleucine + [reduced NADPH---hemoprotein reductase] + O2 = N-hydroxy-L-isoleucine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) N-hydroxy-L-isoleucine + [reduced NADPH---hemoprotein reductase] + O2 = N,N-dihydroxy-L-isoleucine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O (spontaneous) | L-isoleucine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | CYP79D3 (gene name); CYP79D4 (gene name) | |
| 1.14.14.40 | phenylalanine N-monooxygenase | False | 2 | 4 | 0 | 3 | L-phenylalanine + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (E)-phenylacetaldoxime + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) L-phenylalanine + [reduced NADPH---hemoprotein reductase] + O2 = N-hydroxy-L-phenylalanine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) N-hydroxy-L-phenylalanine + [reduced NADPH---hemoprotein reductase] + O2 = N,N-dihydroxy-L-phenylalanine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldoxime + CO2 + H2O | L-phenylalanine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | phenylalanine N-hydroxylase; CYP79A2 (gene name); CYP79D16 (gene name) | |
| 1.14.14.41 | (E)-2-methylbutanal oxime monooxygenase | False | 1 | 0 | 0 | 1 | (1) (E)-2-methylbutanal oxime + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-2-methylbutanal oxime = (Z)-2-methylbutanal oxime;;(1b) (Z)-2-methylbutanal oxime = 2-methylbutanenitrile + H2O;;(1c) 2-methylbutanenitrile + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) (E)-2-methylpropanal oxime + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(2a) (E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime;;(2b) (Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O;;(2c) 2-methylpropanenitrile + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + [oxidized NADPH---hemoprotein reductase] + H2O | (E)-2-methylbutanal oxime,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP71E7 (gene name) | |
| 1.14.14.42 | homomethionine N-monooxygenase | False | 2 | 0 | 0 | 2 | an L-polyhomomethionine + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = an (E)-omega-(methylsulfanyl)alkanal oxime + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) an L-polyhomomethionine + [reduced NADPH---hemoprotein reductase] + O2 = an L-N-hydroxypolyhomomethionine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) an L-N-hydroxypolyhomomethionine + [reduced NADPH---hemoprotein reductase] + O2 = an L-N,N-dihydroxypolyhomomethionine + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) an L-N,N-dihydroxypolyhomomethionine = an (E)-omega-(methylsulfanyl)alkanal oxime + CO2 + H2O | L-polyhomomethionine,[NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP79F1 (gene name); CYP79F2 (gene name) | |
| 1.14.14.43 | (methylsulfanyl)alkanaldoxime N-monooxygenase | False | 1 | 0 | 0 | 3 | an (E)-omega-(methylsulfanyl)alkanal oxime + [reduced NADPH---hemoprotein reductase] + glutathione + O2 = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) an (E)-omega-(methylsulfanyl)alkanal oxime + [reduced NADPH---hemoprotein reductase] + O2 = a 1-(methylsulfanyl)-4-aci-nitroalkane + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O | (E)-omega-(methylsulfanyl)alkananal oxime,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | CYP83A1 (gene name); (methylthio)alkanaldoxime N-monooxygenase; (E)-omega-(methylthio)alkananaldoxime,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | |
| 1.14.99.53 | lytic chitin monooxygenase | False | 2 | 12 | 0 | 17 | [(1->4)-N-acetyl-beta-D-glucosaminyl](m+n) + reduced acceptor + O2 = [(1->4)-N-acetyl-beta-D-glucosaminyl](m-1)-(1->4)-2-(acetylamino)-2-deoxy-D-glucono-1,5-lactone + [(1->4)-N-acetyl-beta-D-glucosaminyl]n + acceptor + H2O | chitin, hydrogen-donor:oxygen oxidoreductase (N-acetyl-beta-D-glucosaminyl C1-hydroxylating/C4-dehdyrogenating) | None | LPMO (ambiguous); CBP21; chitin oxidohydrolase | |
| 1.21.99.5 | tetrachloroethene reductive dehalogenase | False | 5 | 9 | 0 | 12 | trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor | acceptor:trichloroethene oxidoreductase (chlorinating) | None | tetrachloroethene reductase | |
| 2.1.1.337 | reticuline N-methyltransferase | False | 1 | 0 | 0 | 1 | (1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine;;(2) S-adenosyl-L-methionine + (S)-corytuberine = S-adenosyl-L-homocysteine + (S)-magnoflorine | S-adenosyl-L-methionine:(S)-reticuline N-methyltransferase | None | RNMT | |
| 2.1.1.338 | desmethylxanthohumol 6'-O-methyltransferase | False | 2 | 0 | 0 | 1 | S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol | S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase | None | OMT1 (ambiguous) | |
| 2.1.1.339 | xanthohumol 4-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol | S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase | None | OMT2 (ambiguous); S-adenosyl-L-methionine:xanthohumol 4'-O-methyltransferase (incorrect); xanthohumol 4'-O-methyltransferase (incorrect) | |
| 2.3.1.261 | (4-hydroxyphenyl)alkanoate synthase | True | 0 | 0 | 0 | 2 | (1) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H+ = 17-(4-hydroxyphenyl)heptadecanoyl-[(4-hydroxyphenyl)alkanoate synthase] + 8 CO2 + 8 CoA + 16 NADP+ + 8 H2O;;(2) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H+ + holo-[(4-hydroxyphenyl)alkanoate synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(4-hydroxyphenyl)alkanoate synthase] + 9 CO2 + 9 CoA + 18 NADP+ + 9 H2O | malonyl-CoA:4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] malonyltransferase [(4-hydroxyphenyl)alkanoate-forming] | None | msl7 (gene name); Pks15/1 | |
| 2.3.1.262 | anthraniloyl-CoA anthraniloyltransferase | False | 1 | 4 | 0 | 1 | anthraniloyl-CoA + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CoA + CO2 (overall reaction);;(1a) anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = S-anthraniloyl-L-cysteinyl-[PqsD protein] + CoA;;(1b) S-anthraniloyl-L-cysteinyl-[PqsD protein] + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] | anthraniloyl-CoA:malonyl-CoA anthraniloyltransferase | None | pqsD (gene name) | |
| 2.3.1.263 | 2-amino-4-oxopentanoate thiolase | False | 4 | 37 | 0 | 2 | acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate | acetyl-CoA:D-alanine acetyltransferase | None | AKPT; AKP thiolase; 2-amino-4-ketopentanoate thiolase | |
| 2.3.3.18 | 2-phosphinomethylmalate synthase | False | 1 | 0 | 0 | 1 | acetyl-CoA + H2O + 3-(hydroxyphosphinoyl)pyruvate = phosphinomethylmalate + CoA | acetyl-CoA:phosphinopyruvate C-acetyltransferase (thioester-hydrolysing, phosphinomethylmalate-forming) | None | pmmS (gene name) | |
| 2.4.1.343 | UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | UDP-alpha-D-galactose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-galactosyltransferase (configuration-retaining) | None | wclR (gene name) | |
| 2.4.1.344 | type 2 galactoside alpha-(1,2)-fucosyltransferase | False | 31 | 19 | 0 | 7 | GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R | GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting) | None | blood group H alpha-2-fucosyltransferase (ambiguous); guanosine diphosphofucose-galactoside 2-L-fucosyltransferase (ambiguous); alpha-(1->2)-L-fucosyltransferase (ambiguous); alpha-2-fucosyltransferase (ambiguous); alpha-2-L-fucosyltransferase (ambiguous); blood-group substance H-dependent fucosyltransferase (ambiguous); guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous); guanosine diphosphofucose-lactose fucosyltransferase; GDP fucose-lactose fucosyltransferase; guanosine diphospho-L-fucose-lactose fucosyltransferase; guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous); guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous); guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous); H-gene-encoded beta-galactoside alpha(1->2)fucosyltransferase; beta-galactoside alpha(1->2)fucosyltransferase (ambiguous); GDP-L-fucose:lactose fucosyltransferase; GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous); FUT1 (gene name); FUT2 (gene name) | |
| 2.5.1.136 | 2-acylphloroglucinol 4-prenyltransferase | False | 2 | 0 | 0 | 2 | prenyl diphosphate + a 2-acylphloroglucinol = diphosphate + a 2-acyl-4-prenylphloroglucinol | prenyl-diphosphate:2-acylphloroglucinol 4-prenyltransferase | None | PT-1 (gene name); PT1L (gene name); aromatic prenyltransferase (ambiguous); dimethylallyl-diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase | |
| 2.5.1.137 | 2-acyl-4-prenylphloroglucinol 6-prenyltransferase | False | 1 | 0 | 0 | 1 | (1) prenyl diphosphate + a 2-acyl-4-prenylphloroglucinol = diphosphate + a 2-acyl-4,6-bis(prenyl)phloroglucinol;;(2) prenyl diphosphate + a 2-acyl-4,6-bis(prenyl)phloroglucinol = diphosphate + a 2-acyl-4,6,6-tris(prenyl)cyclohexa-2,4-dien-1-one | prenyl-diphosphate:2-acyl-4-prenylphloroglucinol 6-prenyltransferase | None | PT2 (gene name); aromatic prenyltransferase (ambiguous); dimethylallyl-diphosphate:2-acyl-4-prenylphloroglucinol 6-dimethylallyltransferase | |
| 2.5.1.138 | coumarin 8-geranyltransferase | False | 2 | 0 | 0 | 1 | (1) geranyl diphosphate + umbelliferone = diphosphate + 8-geranylumbelliferone;;(2) geranyl diphosphate + esculetin = diphosphate + 8-geranylesculetin | geranyl-diphosphate:umbelliferone 8-geranyltransferase | None | ClPT1 | |
| 2.5.1.139 | umbelliferone 6-dimethylallyltransferase | False | 1 | 0 | 0 | 2 | prenyl diphosphate + umbelliferone = diphosphate + demethylsuberosin | prenyl-diphosphate:umbelliferone 6-prenyltransferase | None | PcPT; dimethylallyl-diphosphate:umbelliferone 6-dimethylallyltransferase | |
| 2.6.1.111 | 3-aminobutanoyl-CoA transaminase | False | 1 | 17 | 0 | 1 | 3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate | 3-aminobutanoyl-CoA:2-oxoglutarate aminotransferase | None | kat (gene name); acyl-CoA beta-transaminase | |
| 2.6.1.112 | (S)-ureidoglycine---glyoxylate transaminase | False | 1 | 49 | 0 | 1 | (S)-ureidoglycine + glyoxylate = N-carbamoyl-2-oxoglycine + glycine | (S)-ureidoglycine:glyoxylate aminotransferase | None | (S)-ureidoglycine---glyoxylate aminotransferase; UGXT; PucG | |
| 2.7.1.216 | farnesol kinase | False | 1 | 2 | 0 | 2 | CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate | CTP:(2E,6E)-farnesol phosphotransferase | None | FOLK (gene name) | |
| 2.7.4.32 | farnesyl phosphate kinase | True | 0 | 0 | 0 | 2 | CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate | CTP:(2E,6E)-farnesyl-phosphate phosphotransferase | None | None | |
| 2.7.8.45 | teichoic acid glycerol-phosphate transferase | False | 1 | 2 | 0 | 1 | CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-glycerol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase | None | tarF (gene name) (ambiguous); teichoic acid glycerol-phosphate primase | |
| 2.7.8.46 | teichoic acid ribitol-phosphate primase | False | 1 | 4 | 0 | 2 | CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-ribitol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitylphosphotransferase | None | Tar primase; tarK (gene name) | |
| 2.7.8.47 | teichoic acid ribitol-phosphate polymerase | False | 1 | 5 | 0 | 2 | n CDP-ribitol + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | CDP-ribitol:4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase | None | Tar polymerase (ambiguous); tarL (gene name) (ambiguous) | |
| 3.2.1.200 | exo-chitinase (non-reducing end) | False | 1 | 0 | 0 | 11 | Hydrolysis of N,N'-diacetylchitobiose from the non-reducing end of chitin and chitodextrins. | (1->4)-2-acetamido-2-deoxy-beta-D-glucan diacetylchitobiohydrolase (non-reducing end) | None | chiB (gene name) | |
| 3.2.1.201 | exo-chitinase (reducing end) | True | 0 | 0 | 0 | 3 | Hydrolysis of N,N'-diacetylchitobiose from the reducing end of chitin and chitodextrins. | (1->4)-2-acetamido-2-deoxy-beta-D-glucan diacetylchitobiohydrolase (reducing end) | None | chiA (gene name) | |
| 3.2.1.202 | endo-chitodextinase | False | 1 | 0 | 0 | 1 | Hydrolysis of chitodextrins, releasing N,N'-diacetylchitobiose and small amounts of N,N',N''-triacetylchitotriose. | (1->4)-2-acetamido-2-deoxy-beta-D-glucan diacetylchitobiohydrolase (endo-cleaving) | None | endo I (gene name); chitodextrinase (ambiguous); endolytic chitodextrinase; periplasmic chitodextrinase | |
| 3.5.1.125 | N2-acetyl-L-2,4-diaminobutanoate deacetylase | False | 1 | 207 | 0 | 1 | (2S)-2-acetamido-4-aminobutanoate + H2O = L-2,4-diaminobutanoate + acetate | (2S)-2-acetamido-4-aminobutanoate amidohydrolase | None | doeB (gene name) | |
| 3.5.1.126 | oxamate amidohydrolase | False | 1 | 37 | 0 | 1 | oxamate + H2O = oxalate + NH3 | oxamate amidohydrolase | None | HpxW | |
| 3.5.1.127 | jasmonoyl-L-amino acid hydrolase | False | 2 | 0 | 0 | 2 | a jasmonoyl-L-amino acid + H2O = jasmonate + an L-amino acid | jasmonoyl-L-amino acid amidohydrolase | None | IAR3 (gene name); ILL4 (gene name); ILL6 (gene name) | |
| 3.5.4.44 | ectoine hydrolase | False | 1 | 707 | 0 | 1 | ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate | ectoine aminohydrolase | None | doeA (gene name) | |
| 3.5.4.45 | melamine deaminase | False | 1 | 14 | 0 | 1 | (1) melamine + H2O = ammeline + NH3;;(2) ammeline + H2O = ammelide + NH3 | melamine aminohydrolase | None | triA (gene name) | |
| 3.5.4.46 | cAMP deaminase | False | 1 | 1 | 0 | 1 | 3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3 | 3',5'-cyclic AMP aminohydrolase | None | cyclic adenylate deaminase; CadD | |
| 4.4.1.35 | L-cystine beta-lyase | False | 1 | 0 | 0 | 2 | L-cystine + H2O = L-thiocysteine + pyruvate + NH3 (overall reaction);;(1a) L-cystine = L-thiocysteine + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | L-cystine thiocysteine-lyase (deaminating; pyruvate-forming) | None | CORI3 (gene name) | |
| 5.1.1.22 | 4-hydroxyproline betaine 2-epimerase | False | 2 | 1 | 0 | 2 | (1) trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine;;(2) L-proline betaine = D-proline betaine | 4-hydroxyproline betaine 2-epimerase | None | hpbD (gene name); Hyp-B 2-epimerase; (4R)-4-hydroxyproline betaine 2-epimerase | |
| 5.1.2.7 | tagaturonate epimerase | False | 1 | 1303 | 3 | 1 | D-tagaturonate = D-fructuronate | D-tagaturonate 3-epimerase | None | fructuronate epimerase; tagaturonate/fructuronate epimerase; UxaE | |
| 5.1.3.40 | D-tagatose 6-phosphate 4-epimerase | False | 1 | 0 | 0 | 1 | D-tagatose 6-phosphate = D-fructose 6-phosphate | D-tagatose 6-phosphate 4-epimerase | None | None | |
| 5.4.99.64 | 2-hydroxyisobutanoyl-CoA mutase | False | 2 | 0 | 0 | 2 | 2-hydroxy-2-methylpropanoyl-CoA = (S)-3-hydroxybutanoyl-CoA | 2-hydroxy-2-methylpropanoyl-CoA mutase | None | hcmAB (gene names) | |
| 6.2.1.48 | carnitine---CoA ligase | False | 43 | 924 | 0 | 2 | ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA | L-carnitine:CoA ligase (AMP-forming) | None | caiC (gene name) | |
| 6.5.1.8 | 3'-phosphate/5'-hydroxy nucleic acid ligase | False | 55 | 20736 | 11 | 14 | (1) (ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP = (ribonucleotide)n+m + GMP + diphosphate (overall reaction);;(1a) GTP + [RNA ligase]-L-histidine = [RNA ligase]-Ntau-(5'-guanosyl-phosphono)-L-histidine + diphosphate;;(1b) [RNA ligase]-Ntau-(5'-guanosyl-phosphono)-L-histidine + (ribonucleotide)n-3'-phosphate = (ribonucleotide)n-3'-(5'-diphosphoguanosine) + [RNA ligase]-L-histidine;;(1c) (ribonucleotide)n-3'-(5'-diphosphoguanosine) + 5'-hydroxy-(ribonucleotide)m = (ribonucleotide)n+m + GMP;;(2) (ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O = (ribonucleotide)n+m + GMP + diphosphate (overall reaction);;(2a) (ribonucleotide)n-2',3'-cyclophosphate + H2O = (ribonucleotide)n-3'-phosphate;;(2b) GTP + [RNA ligase]-L-histidine = [RNA ligase]-Ntau-(5'-guanosyl-phosphono)-L-histidine + diphosphate;;(2c) [RNA ligase]-Ntau-(5'-guanosyl-phosphono)-L-histidine + (ribonucleotide)n-3'-phosphate = (ribonucleotide)n-3'-(5'-diphosphoguanosine) + [RNA ligase]-L-histidine;;(2d) (ribonucleotide)n-3'-(5'-diphosphoguanosine) + 5'-hydroxy-(ribonucleotide)m = (ribonucleotide)n+m + GMP | poly(ribonucleotide)-3'-phosphate:5'-hydroxy-poly(ribonucleotide) ligase (GMP-forming) | None | rtcB (gene name) | |
| 1.1.1.408 | 4-phospho-D-threonate 3-dehydrogenase | False | 19 | 283 | 0 | 2 | 4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+ (overall reaction);;(1a) 4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-erythronate + NADH + H+;;(1b) 3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2 (spontaneous) | 4-phospho-D-threonate:NAD+ 3-oxidoreductase | None | pdxA2 (gene name) (ambiguous) | |
| 1.1.1.409 | 4-phospho-D-erythronate 3-dehydrogenase | False | 1 | 42 | 0 | 2 | 4-phospho-D-erythronate + NAD+ = glycerone phosphate + CO2 + NADH + H+ (overall reaction);;(1a) 4-phospho-D-erythronate + NAD+ = 3-dehydro-4-phospho-L-threonate + NADH + H+;;(1b) 3-dehydro-4-phospho-L-threonate = glycerone phosphate + CO2 (spontaneous) | 4-phospho-D-erythronate:NAD+ 3-oxidoreductase | None | pdxA2 (gene name) (ambiguous) | |
| 1.1.1.410 | D-erythronate 2-dehydrogenase | False | 2 | 88 | 0 | 1 | D-erythronate + NAD+ = 2-dehydro-D-erythronate + NADH + H+ | D-erythronate:NAD+ 2-oxidoreductase | None | denD (gene name) | |
| 1.1.1.411 | L-threonate 2-dehydrogenase | False | 5 | 3404 | 0 | 4 | L-threonate + NAD+ = 2-dehydro-L-erythronate + NADH + H+ | L-threonate:NAD+ 2-oxidoreductase | None | ltnD (gene name) | |
| 1.2.1.99 | 4-(gamma-glutamylamino)butanal dehydrogenase | False | 0 | 1 | 0 | 2 | 4-(gamma-L-glutamylamino)butanal + NAD(P)+ + H2O = 4-(gamma-L-glutamylamino)butanoate + NAD(P)H + H+ | 4-(gamma-L-glutamylamino)butanal:NAD(P)+ oxidoreductase | None | puuC (gene name) | |
| 1.2.7.12 | formylmethanofuran dehydrogenase | False | 13 | 2623 | 0 | 13 | a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | formylmethanofuran:ferredoxin oxidoreductase | None | formylmethanofuran:acceptor oxidoreductase | |
| 1.7.1.16 | nitrobenzene nitroreductase | False | 2 | 64 | 0 | 9 | N-phenylhydroxylamine + 2 NADP+ + H2O = nitrobenzene + 2 NADPH + 2 H+ (overall reaction);;(1a) N-phenylhydroxylamine + NADP+ = nitrosobenzene + NADPH + H+;;(1b) nitrosobenzene + NADP+ + H2O = nitrobenzene + NADPH + H+ | N-phenylhydroxylamine:NADP+ oxidoreductase | None | cnbA (gene name) | |
| 1.14.13.235 | indole-3-acetate monooxygenase | False | 2 | 4 | 0 | 1 | (indol-3-yl)acetate + NADH + H+ + O2 = (2-hydroxy-1H-indol-3-yl)acetate + NAD+ + H2O | (indol-3-yl)acetate,NADH:oxygen oxidoreductase (2-hydroxylating) | None | iacA (gene name) | |
| 1.14.13.236 | toluene 4-monooxygenase | False | 3 | 22 | 0 | 4 | toluene + NADH + H+ + O2 = 4-methylphenol + NAD+ + H2O | toluene,NADH:oxygen oxidoreductase (4-hydroxylating) | None | TMO | |
| 1.14.14.44 | phenylacetaldehyde oxime monooxygenase | False | 1 | 0 | 0 | 1 | (E)-phenylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + O2 = (R)-mandelonitrile + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime;;(1b) (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O;;(1c) phenylacetonitrile + [reduced NADPH---hemoprotein reductase] + O2 = (R)-mandelonitrile + [oxidized NADPH---hemoprotein reductase] + H2O | (E)-phenylacetaldehyde oxime,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP71AN24 (gene name) | |
| 1.14.14.45 | aromatic aldoxime N-monooxygenase | False | 1 | 0 | 0 | 2 | (1) (E)-indol-3-ylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + glutathione + O2 = S-[(E)-N-hydroxy(indol-3-yl)acetimidoyl]-L-glutathione + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-indol-3-ylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + O2 = 1-(1H-indol-3-yl)-2-aci-nitroethane + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 1-(1H-indol-3-yl)-2-aci-nitroethane + glutathione = S-[(E)-N-hydroxy(indol-3-yl)acetimidoyl]-L-glutathione + H2O (spontaneous);;(2) (E)-phenylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + glutathione + O2 = S-[(Z)-N-hydroxy(phenyl)acetimidoyl]-L-glutathione + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(2a) (E)-phenylacetaldehyde oxime + [reduced NADPH---hemoprotein reductase] + O2 = 1-aci-nitro-2-phenylethane + [oxidized NADPH---hemoprotein reductase] + H2O;;(2b) 1-aci-nitro-2-phenylethane + glutathione = S-[(Z)-N-hydroxy(phenyl)acetimidoyl]-L-glutathione + H2O (spontaneous);; | (E)-indol-3-ylacetaldoxime,[reduced NADPH---hemoprotein reductase],glutathione:oxygen oxidoreductase (oxime-hydroxylating) | None | CYP83B1 (gene name) | |
| 1.14.14.46 | pimeloyl-[acyl-carrier protein] synthase | False | 1 | 169 | 0 | 1 | a long-chain acyl-[acyl-carrier protein] + 2 reduced flavodoxin + 3 O2 = pimeloyl-[acyl-carrier protein] + an n-alkanal + 2 oxidized flavodoxin + 3 H2O (overall reaction);;(1a) a long-chain acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = a (7S)-7-hydroxy-long-chain-acyl-[acyl-carrier protein] + oxidized flavodoxin + H2O;;(1b) a (7S)-7-hydroxy-long-chain-acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = a (7R,8R)-7,8-dihydroxy-long-chain-acyl-[acyl-carrier protein] + oxidized flavodoxin + H2O;;(1c) a (7R,8R)-7,8-dihydroxy-long-chain-acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = a 7-oxoheptanoyl-[acyl-carrier protein] + an n-alkanal + oxidized flavodoxin + 2 H2O;;(1d) a 7-oxoheptanoyl-[acyl-carrier protein] + oxidized flavodoxin + H2O = a pimeloyl-[acyl-carrier protein] + reduced flavodoxin + H+ | acyl-[acyl-carrier protein],reduced-flavodoxin:oxygen oxidoreductase (pimeloyl-[acyl-carrier protein]-forming) | None | bioI (gene name); P450BioI; CYP107H1 | |
| 1.14.14.47 | nitric-oxide synthase (flavodoxin) | False | 9 | 1930 | 8 | 8 | 2 L-arginine + 3 reduced flavodoxin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H2O (overall reaction);;(1a) 2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O ;;(1b) 2 Nomega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O | L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming) | None | nitric oxide synthetase (ambiguous); NO synthase (ambiguous) | |
| 1.14.19.51 | (S)-corytuberine synthase | False | 1 | 0 | 0 | 1 | (S)-reticuline + [reduced NADPH---hemoprotein reductase] + O2 = (S)-corytuberine + [oxidized NADPH---hemoprotein reductase] + 2 H2O. | (S)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling; (S)-corytuberine-forming) | None | CYP80G2 | |
| 1.14.99.54 | lytic cellulose monooxygenase (C1-hydroxylating) | False | 1 | 4 | 0 | 25 | [(1->4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = [(1->4)-beta-D-glucosyl]m-1-(1->4)-D-glucono-1,5-lactone + [(1->4)-beta-D-glucosyl]n + acceptor + H2O | cellulose, hydrogen-donor:oxygen oxidoreductase (D-glucosyl C1-hydroxylating) | None | lytic polysaccharide monooxygenase (ambiguous); LPMO (ambiguous); LPMO9A | |
| 1.14.99.55 | lytic starch monooxygenase | False | 5 | 2 | 0 | 5 | starch + reduced acceptor + O2 = D-glucono-1,5-lactone-terminated malto-oligosaccharides + short-chain malto-oligosaccharides + acceptor + H2O | starch, hydrogen-donor:oxygen oxidoreductase (D-glucosyl C1-hydroxylating) | None | LPMO (ambiguous) | |
| 1.14.99.56 | lytic cellulose monooxygenase (C4-dehydrogenating) | False | 1 | 0 | 11 | 13 | [(1->4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1->4)-beta-D-glucosyl]n-1 + [(1->4)-beta-D-glucosyl]m + acceptor + H2O | cellulose, hydrogen-donor:oxygen oxidoreductase (D-glucosyl 4-dehydrogenating) | None | None | |
| 1.14.99.57 | heme oxygenase (mycobilin-producing) | False | 2 | 14 | 1 | 1 | (1) protoheme + 3 reduced acceptor + 3 O2 = mycobilin a + Fe2+ + 3 acceptor + 3 H2O;;(2) protoheme + 3 reduced acceptor + 3 O2 = mycobilin b + Fe2+ + 3 acceptor + 3 H2O | protoheme,donor:oxygen oxidoreductase (mycobilin-producing) | None | mhuD (gene name) | |
| 2.1.1.340 | 3-aminomethylindole N-methyltransferase | False | 1 | 0 | 0 | 2 | 2 S-adenosyl-L-methionine + 3-(aminomethyl)indole = 2 S-adenosyl-L-homocysteine + gramine (overall reaction);;(1a) S-adenosyl-L-methionine + 3-(aminomethyl)indole = S-adenosyl-L-homocysteine + (1H-indol-3-yl)-N-methylmethanamine;;(1b) S-adenosyl-L-methionine + (1H-indol-3-yl)-N-methylmethanamine = S-adenosyl-L-homocysteine + gramine | S-adenosyl-L-methionine:3-(aminomethyl)indole N-methyltransferase (gramine-forming) | None | NMT (gene name) | |
| 2.1.1.341 | vanillate/3-O-methylgallate O-demethylase | False | 1 | 4 | 0 | 3 | (1) vanillate + tetrahydrofolate = protocatechuate + 5-methyltetrahydrofolate;;(2) 3-O-methylgallate + tetrahydrofolate = gallate + 5-methyltetrahydrofolate | vanillate:tetrahydrofolate O-methyltransferase | None | ligM (gene name) | |
| 2.1.1.342 | anaerobilin synthase | False | 1 | 1 | 0 | 1 | 2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin | S-adenosyl-L-methionine:protoheme C-methyltransferase (anaerobilin-producing) | None | chuW (gene name) | |
| 2.3.1.264 | beta-lysine N6-acetyltransferase | False | 3 | 5 | 0 | 3 | acetyl-CoA + (3S)-3,6-diaminohexanoate = CoA + (3S)-6-acetamido-3-aminohexanoate | acetyl-CoA:(3S)-3,6-diaminohexanoate N6-acetyltransferase | None | ablB (gene name) | |
| 2.3.3.19 | 2-phosphonomethylmalate synthase | False | 1 | 2 | 0 | 2 | acetyl-CoA + H2O + 3-phosphonopyruvate = (R)-2-(phosphonomethyl)malate + CoA | acetyl-CoA:3-phosphonopyruvate C-acetyltransferase | None | 2-phosphinomethylmalic acid synthase; PMM synthase | |
| 2.4.1.346 | phosphatidyl-myo-inositol dimannoside synthase | False | 4 | 116 | 0 | 3 | (1) GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol;;(2) GDP-alpha-D-mannose + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol | GDP-alpha-D-mannose:2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol 6-alpha-D-mannosyltransferase (configuration-retaining) | None | mannosyltransferase PimB; PimB; guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase (ambiguous) | |
| 2.5.1.140 | N-(2-amino-2-carboxyethyl)-L-glutamate synthase | False | 20 | 866 | 0 | 1 | O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate | O-phospho-L-serine:L-glutamate N-(2S)-2-amino-2-carboxyethyltransferase | None | SbnA; ACEGA synthase | |
| 2.6.1.113 | putrescine---pyruvate transaminase | False | 1 | 219 | 0 | 2 | putrescine + pyruvate = 4-aminobutanal + alanine | putrescine:pyruvate aminotransferase | None | spuC (gene name) | |
| 2.7.1.217 | 3-dehydrotetronate 4-kinase | False | 11 | 4957 | 0 | 2 | (1) ATP + 3-dehydro-L-erythronate = ADP + 3-dehydro-4-phospho-L-erythronate;;(2) ATP + 3-dehydro-D-erythronate = ADP + 3-dehydro-4-phospho-D-erythronate | ATP:3-dehydrotetronate 4-phosphotransferase | None | otnK (gene name) | |
| 2.8.1.15 | tRNA-5-methyluridine54 2-sulfurtransferase | False | 1 | 20 | 1 | 2 | ATP + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + 5-methyluracil54 in tRNA + H2O = AMP + diphosphate + 5-methyl-2-thiouracil54 in tRNA + [TtuB sulfur-carrier protein]-Gly-Gly | [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH:tRNA (5-methyluridine54-2-O)-sulfurtransferase | None | TtuA | |
| 3.2.1.203 | carboxymethylcellulase | True | 0 | 0 | 0 | 8 | Endohydrolysis of (1->4)-beta-D-glucosidic linkages in (carboxymethyl)cellulose. | 4-beta-D-(carboxymethyl)glucan 4-(carboxymethyl)glucanohydrolase | None | CMCase | |
| 3.5.99.11 | 2-aminomuconate deaminase (2-hydroxymuconate-forming) | False | 1 | 3 | 0 | 2 | 2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3 | 2-aminomuconate aminohydrolase [(2Z,4E)-2-hydroxyhexa-2,4-dienedioate-forming] | None | cnbZ (gene name) | |
| 3.13.1.5 | carbon disulfide hydrolase | False | 4 | 5 | 0 | 3 | carbon disulfide + 2 H2O = CO2 + 2 hydrogen sulfide (overall reaction);;(1a) carbon disulfide + H2O = carbonyl sulfide + hydrogen sulfide;;(1b) carbonyl sulfide + H2O = CO2 + hydrogen sulfide | carbon-disulfide hydrogen-sulfide-lyase (decarboxylating) | None | CS2 hydrolase (misleading); carbon disulfide lyase; CS2-converting enzyme; carbon disulphide-lyase (decarboxylating) | |
| 4.1.1.104 | 3-dehydro-4-phosphotetronate decarboxylase | False | 5 | 3708 | 0 | 4 | (1) 3-dehydro-4-phospho-L-erythronate = glycerone phosphate + CO2;;(2) 3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2 | 3-dehydro-4-phosphotetronate carboxy-lyase | None | otnC (gene name) | |
| 4.1.2.59 | dihydroneopterin phosphate aldolase | False | 1 | 1 | 0 | 1 | 7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate | 7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] | None | H2NMP aldolase | |
| 4.1.2.60 | dihydroneopterin triphosphate aldolase | True | 0 | 0 | 0 | 6 | 7,8-dihydroneopterin 3'-triphosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate | 7,8-dihydroneopterin 3'-triphosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] | None | PTPS-III | |
| 4.99.1.10 | magnesium dechelatase | False | 3 | 0 | 0 | 11 | (1) chlorophyll a + 2 H+ = pheophytin a + Mg2+;;(2) chlorophyllide a + 2 H+ = pheophorbide a + Mg2+ | chlorophyll a magnesium lyase | None | SGR (gene name); SGRL (gene name); Mg-dechelatase | |
| 4.99.1.11 | sirohydrochlorin nickelchelatase | False | 9 | 326 | 0 | 2 | Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ | Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming) | None | cfbA (gene name) | |
| 5.1.3.41 | fructoselysine 3-epimerase | False | 3 | 27 | 0 | 1 | N6-(D-fructosyl)-L-lysine = N6-(D-psicosyl)-L-lysine | D-fructosyl-L-lysine 3-epimerase | None | frlC (gene name) | |
| 5.3.1.35 | 2-dehydrotetronate isomerase | False | 4 | 92 | 0 | 1 | (1) 2-dehydro-L-erythronate = 3-dehydro-L-erythronate;;(2) 2-dehydro-D-erythronate = 3-dehydro-D-erythronate | 2-dehydrotetronate isomerase | None | otnI (gene name) | |
| 6.2.1.49 | long-chain fatty acid adenylyltransferase FadD28 | False | 4 | 0 | 0 | 2 | ATP + a long-chain fatty acid + holo-[mycocerosate synthase] = AMP + diphosphate + a long-chain acyl-[mycocerosate synthase] (overall reaction);;(1a) ATP + a long-chain fatty acid = diphosphate + a long-chain acyl-adenylate ester;;(1b) a long-chain acyl-adenylate ester + holo-[mycocerosate synthase] = AMP + a long-chain acyl-[mycocerosate synthase] | long-chain fatty acid:holo-[mycocerosate synthase] ligase (AMP-forming) | None | fadD28 (gene name) | |
| 6.3.2.50 | tenuazonic acid synthetase | False | 4 | 0 | 0 | 1 | ATP + L-isoleucine + acetoacetyl-CoA = AMP + diphosphate + tenuazonic acid + CoA | L-isoleucine:acetoacetyl-CoA ligase (tenuazonic acid-forming) | None | TAS1 (gene name) | |
| 6.3.2.51 | phosphopantothenate---cysteine ligase (ATP) | False | 3 | 57 | 1 | 7 | ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | (R)-4'-phosphopantothenate:L-cysteine ligase (ATP-utilizing) | None | phosphopantothenoylcysteine synthetase (ambiguous); PPCS (gene name) | |
| 6.3.3.7 | Ni-sirohydrochlorin a,c-diamide reductive cyclase | False | 6 | 42 | 0 | 4 | ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor | Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming) | None | cfbC (gene name); cfbD (gene name) | |
| 6.3.5.12 | Ni-sirohydrochlorin a,c-diamide synthase | False | 9 | 662 | 0 | 1 | 2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate | Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming) | None | cfbB (gene name) | |
| 6.4.1.9 | coenzyme F430 synthetase | False | 3 | 17 | 0 | 2 | ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 | 15,173-seco-F430-173-acid cyclo-ligase (ADP-forming) | None | cfbE (gene name) | |
| 1.1.1.413 | A-factor type gamma-butyrolactone 1'-reductase (1S-forming) | False | 1 | 24 | 0 | 1 | a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ | (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase | None | barS1 (gene name) | |
| 1.1.99.41 | 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase | False | 1 | 0 | 0 | 1 | (1) (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor;;(2) (3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor | (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine:acceptor oxidoreductase | None | T3R; tabersonine 3-reductase | |
| 1.5.5.3 | hydroxyproline dehydrogenase | False | 5 | 6 | 0 | 3 | trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol | trans-4-hydroxy-L-proline:quinone oxidoreductase | None | HYPDH; OH-POX; hydroxyproline oxidase; PRODH2 (gene name) | |
| 1.5.98.3 | coenzyme F420:methanophenazine dehydrogenase | False | 15 | 130 | 0 | 4 | reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine | reduced coenzyme F420:methanophenazine oxidoreductase | None | F420H2 dehydrogenase; fpoBCDIF (gene names) | |
| 1.8.1.20 | 4,4'-dithiodibutanoate disulfide reductase | False | 1 | 2 | 0 | 1 | 2 4-sulfanylbutanoate + NAD+ = 4,4'-disulfanediyldibutanoate + NADH + H+ | 4-sulfanylbutanoate:NAD+ oxidoreductase | None | None | |
| 1.8.3.7 | formylglycine-generating enzyme | False | 6 | 131 | 14 | 7 | a [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | [sulfatase]-L-cysteine:oxygen oxidoreductase (3-oxo-L-alanine-forming) | None | sulfatase-modifying factor 1; Calpha-formylglycine-generating enzyme 1; SUMF1 (gene name) | |
| 1.13.11.83 | 4-hydroxy-3-prenylphenylpyruvate oxygenase | False | 1 | 60 | 0 | 1 | 3-(4-hydroxy-3-prenylphenyl)pyruvate + O2 = 4-hydroxy-3-prenylmandelate + CO2 | 3-(4-hydroxy-3-prenylphenyl)pyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate-forming) | None | CloR | |
| 1.13.12.23 | 4-hydroxy-3-prenylbenzoate synthase | False | 1 | 0 | 0 | 1 | 4-hydroxy-3-prenylmandelate + O2 = 4-hydroxy-3-prenylbenzoate + CO2 + H2O | 4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming) | None | CloR; novR (gene name) | |
| 1.14.13.237 | aliphatic glucosinolate S-oxygenase | False | 5 | 0 | 0 | 2 | an omega-(methylsulfanyl)alkyl-glucosinolate + NADPH + H+ + O2 = an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O | omega-(methylsulfanyl)alkyl-glucosinolate,NADPH:oxygen S-oxidoreductase | None | omega-(methylthio)alkylglucosinolate S-oxygenase; GS-OX1 (gene name); omega-(methylthio)alkyl-glucosinolate,NADPH:oxygen S-oxidoreductase | |
| 1.14.13.238 | dimethylamine monooxygenase | False | 0 | 2 | 0 | 3 | dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O | dimethylamine,NADPH:oxygen oxidoreductase (formaldehyde-forming) | None | dmmABC (gene names) | |
| 1.14.14.48 | jasmonoyl-L-amino acid 12-hydroxylase | False | 2 | 0 | 0 | 2 | a jasmonoyl-L-amino acid + [reduced NADPH---hemoprotein reductase] + O2 = a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH---hemoprotein reductase] + H2O | jasmonoyl-L-amino acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating) | None | CYP94B1 (gene name); CYP94B3 (gene name) | |
| 1.14.14.49 | 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase | False | 1 | 0 | 0 | 1 | a 12-hydroxyjasmonoyl-L-amino acid + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) a 12-hydroxyjasmonoyl-L-amino acid + [reduced NADPH---hemoprotein reductase] + O2 = a 12-oxojasmonoyl-L-amino acid + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1b) a 12-oxojasmonoyl-L-amino acid + [reduced NADPH---hemoprotein reductase] + O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + [oxidized NADPH---hemoprotein reductase] + H2O | 12-hydroxyjasmonoyl-L-amino acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating) | None | CYP94C1 (gene name) | |
| 1.14.14.50 | tabersonine 3-oxygenase | False | 1 | 0 | 0 | 1 | (1) 16-methoxytabersonine + [reduced NADPH---hemoprotein reductase] + O2 = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) tabersonine + [reduced NADPH---hemoprotein reductase] + O2 = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH---hemoprotein reductase] + H2O | 16-methoxytabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating) | None | T3O; CYP71D1V2 | |
| 1.14.14.51 | (S)-limonene 6-monooxygenase | False | 11 | 176 | 0 | 12 | (S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-trans-carveol + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) | None | (-)-limonene 6-hydroxylase; (-)-limonene 6-monooxygenase; (-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) | |
| 1.14.14.52 | (S)-limonene 7-monooxygenase | False | 3 | 0 | 0 | 2 | (S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-perillyl alcohol + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7-hydroxylating) | None | (-)-limonene 7-monooxygenase; (-)-limonene hydroxylase; (-)-limonene monooxygenase; (-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) | |
| 1.14.14.53 | (R)-limonene 6-monooxygenase | False | 7 | 0 | 0 | 1 | (R)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (+)-trans-carveol + [oxidized NADPH---hemoprotein reductase] + H2O | (R)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) | None | (+)-limonene-6-hydroxylase; (+)-limonene 6-monooxygenase | |
| 1.14.14.54 | phenylacetate 2-hydroxylase | False | 1 | 9 | 0 | 2 | phenylacetate + [reduced NADPH---hemoprotein reductase] + O2 = (2-hydroxyphenyl)acetate + [oxidized NADPH---hemoprotein reductase] + H2O | phenylacetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) | None | CYP504; phaA (gene name) | |
| 1.14.15.23 | chloroacetanilide N-alkylformylase | False | 1 | 1 | 0 | 2 | butachlor + 2 reduced ferredoxin [iron-sulfur] cluster + O2 = 2-chloro-N-(2,6-diethylphenyl)acetamide + butyl formate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | butachlor,ferredoxin:oxygen oxidoreductase (butyl formate-releasing) | None | cndA (gene name) | |
| 1.14.18.9 | 4alpha-methylsterol monooxygenase | False | 16 | 120 | 0 | 5 | 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O (overall reaction);;(1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 ferricytochrome b5 + H2O;;(1b) 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 ferricytochrome b5 + 2 H2O;;(1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 ferricytochrome b5 + H2O | 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase (C4alpha-methyl-hydroxylating) | None | methylsterol hydroxylase (ambiguous); 4-methylsterol oxidase (ambiguous); 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) (ambiguous); methylsterol monooxygenase (ambiguous); ERG25 (gene name); MSMO1 (gene name); 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase (hydroxylating) (ambiguous) | |
| 1.14.19.52 | camalexin synthase | False | 1 | 0 | 0 | 1 | 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = camalexin + hydrogen cyanide + CO2 + 2 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + [reduced NADPH---hemoprotein reductase] + O2 = (R)-dihydrocamalexate + hydrogen cyanide + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1b) (R)-dihydrocamalexate + [reduced NADPH---hemoprotein reductase] + O2 = camalexin + CO2 + [oxidized NADPH---hemoprotein reductase] + 2 H2O | 2-(cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile, [reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (camalexin-forming) | None | CYP71B15 (gene name); bifunctional dihydrocamalexate synthase/camalexin synthase | |
| 1.14.99.58 | heme oxygenase (biliverdin-IX-beta and delta-forming) | False | 2 | 14 | 0 | 5 | (1) protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-delta + CO + Fe2+ + 3 acceptor + 3 H2O;;(2) protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-beta + CO + Fe2+ + 3 acceptor + 3 H2O | protoheme,donor:oxygen oxidoreductase (biliverdin-IX-beta and delta-forming) | None | pigA (gene name) | |
| 1.16.3.3 | manganese oxidase | False | 0 | 15 | 0 | 5 | 4 Mn2+ + 2 O2 + 4 H2O = 4 MnIVO2 + 8 H+ (overall reaction);;(1a) 4 Mn2+ + O2 + 4 H+ = 4 Mn3+ + 2 H2O;;(1b) 4 Mn3+ + O2 + 6 H2O = 4 MnIVO2 + 12 H+ | manganese(II):oxygen oxidoreductase | None | mnxG (gene name); mofA (gene name); moxA (gene name); cotA (gene name) | |
| 1.17.1.9 | formate dehydrogenase | False | 36 | 12923 | 30 | 47 | formate + NAD+ = CO2 + NADH | formate:NAD+ oxidoreductase | None | formate-NAD+ oxidoreductase; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD+-linked formate dehydrogenase; NAD+-dependent formate dehydrogenase; formate dehydrogenase (NAD+); NAD+-formate dehydrogenase; formate benzyl-viologen oxidoreductase; formic acid dehydrogenase | |
| 1.17.1.10 | formate dehydrogenase (NADP+) | False | 0 | 35 | 1 | 8 | formate + NADP+ = CO2 + NADPH | formate:NADP+ oxidoreductase | None | NADP+-dependent formate dehydrogenase | |
| 1.17.1.11 | formate dehydrogenase (NAD+, ferredoxin) | True | 0 | 0 | 0 | 1 | 2 formate + NAD+ + 2 oxidized ferredoxin [iron-sulfur] cluster = 2 CO2 + NADH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster | formate:NAD+, ferredoxin oxidoreductase | None | electron-bifurcating formate dehydrogenase | |
| 1.17.2.3 | formate dehydrogenase (cytochrome-c-553) | False | 1 | 11 | 0 | 2 | formate + 2 ferricytochrome c-553 = CO2 + 2 ferrocytochrome c-553 + H+ | formate:ferricytochrome-c-553 oxidoreductase | None | None | |
| 1.17.5.3 | formate dehydrogenase-N | False | 1 | 1511 | 0 | 3 | formate + a quinone = CO2 + a quinol | formate:quinone oxidoreductase | None | Fdh-N; FdnGHI; nitrate-inducible formate dehydrogenase; formate dehydrogenase N; FDH-N; nitrate inducible Fdn; nitrate inducible formate dehydrogenase | |
| 1.17.98.3 | formate dehydrogenase (coenzyme F420) | False | 0 | 8 | 0 | 4 | formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420 | formate:coenzyme-F420 oxidoreductase | None | coenzyme F420 reducing formate dehydrogenase; coenzyme F420-dependent formate dehydrogenase | |
| 2.1.1.343 | 8-amino-8-demethylriboflavin N,N-dimethyltransferase | False | 1 | 0 | 0 | 1 | 2 S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin = 2 S-adenosyl-L-homocysteine + roseoflavin (overall reaction);;(1a) S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin = S-adenosyl-L-homocysteine + 8-demethyl-8-(methylamino)riboflavin;;(1b) S-adenosyl-L-methionine + 8-demethyl-8-(methylamino)riboflavin = S-adenosyl-L-homocysteine + roseoflavin | S-adenosyl-L-methionine:8-amino-8-demethylriboflavin N,N-dimethyltransferase | None | rosA (gene name) | |
| 2.1.1.344 | ornithine lipid N-methyltransferase | False | 1 | 6 | 0 | 1 | 3 S-adenosyl-L-methionine + an ornithine lipid = 3 S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid (overall reaction);;(1a) S-adenosyl-L-methionine + an ornithine lipid = S-adenosyl-L-homocysteine + an N-methylornithine lipid;;(1b) S-adenosyl-L-methionine + an N-methylornithine lipid = S-adenosyl-L-homocysteine + an N,N-dimethylornithine lipid;;(1c) S-adenosyl-L-methionine + an N,N-dimethylornithine lipid = S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid | S-adenosyl-L-methionine:ornithine lipid N-methyltransferase | None | olsG (gene name) | |
| 2.3.1.265 | phosphatidylinositol dimannoside acyltransferase | False | 3 | 8 | 1 | 2 | (1) an acyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol;;(2) an acyl-CoA + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol | acyl-CoA:2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol acyltransferase | None | PIM2 acyltransferase; ptfP1 (gene name) | |
| 2.3.2.30 | L-ornithine Nalpha-acyltransferase | False | 5 | 16333 | 0 | 3 | L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a lyso-ornithine lipid + a holo-[acyl-carrier protein] | L-ornithine Nalpha-(3R)-3-hydroxy-acyltransferase | None | olsB (gene name) | |
| 2.4.1.347 | alpha,alpha-trehalose-phosphate synthase (ADP-forming) | False | 16 | 969 | 0 | 4 | ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate | ADP-alpha-D-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase (configuration-retaining) | None | otsA (gene name); ADP-glucose---glucose-phosphate glucosyltransferase | |
| 2.5.1.141 | heme o synthase | False | 537 | 31823 | 0 | 8 | (2E,6E)-farnesyl diphosphate + protoheme IX + H2O = diphosphate + ferroheme o | (2E,6E)-farnesyl-diphosphate:protoheme IX farnesyltranstransferase | None | ctaB (gene name); COX10 (gene name) | |
| 2.7.1.218 | fructoselysine 6-kinase | False | 3 | 33 | 0 | 2 | ATP + N6-(D-fructosyl)-L-lysine = ADP + N6-(6-phospho-D-fructosyl)-L-lysine | ATP:D-fructosyl-L-lysine 6-phosphotransferase | None | frlD (gene name) | |
| 2.7.1.219 | D-threonate 4-kinase | False | 4 | 48 | 0 | 2 | ATP + D-threonate = ADP + 4-phospho-D-threonate | ATP:D-threonate 4-phosphotransferase | None | dtnK (gene name) | |
| 2.7.1.220 | D-erythronate 4-kinase | False | 1 | 11 | 0 | 1 | ATP + D-erythronate = ADP + 4-phospho-D-erythronate | ATP:D-erythronate 4-phosphotransferase | None | denK (gene name) | |
| 2.7.1.221 | N-acetylmuramate 1-kinase | False | 4 | 85 | 0 | 2 | ATP + N-acetyl-D-muramate = ADP + N-acetyl-alpha-D-muramate 1-phosphate | ATP:N-acetyl-D-muramate 1-phosphotransferase | None | amgK (gene name) | |
| 2.7.7.99 | N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase | False | 4 | 103 | 0 | 1 | UDP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + phosphate | UDP:N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase | None | murU (gene name) | |
| 2.8.2.38 | aliphatic desulfoglucosinolate sulfotransferase | False | 2 | 0 | 0 | 2 | 3'-phosphoadenylyl sulfate + an aliphatic desulfoglucosinolate = adenosine 3',5'-bisphosphate + an aliphatic glucosinolate | 3'-phosphoadenylyl-sulfate:aliphatic desulfoglucosinolate sulfonotransferase | None | SOT17 (gene name); SOT18 (gene name); 3'-phosphoadenylyl-sulfate:aliphatic desulfoglucosinolate sulfotransferase | |
| 2.8.2.39 | hydroxyjasmonate sulfotransferase | False | 1 | 0 | 0 | 1 | 3'-phosphoadenylyl-sulfate + 12-hydroxyjasmonate = adenosine 3',5'-bisphosphate + 12-sulfooxyjasmonate | 3'-phosphoadenylyl-sulfate:12-hydroxyjasmonate sulfonotransferase | None | ST2A (gene name); 3'-phosphoadenylyl-sulfate:12-hydroxyjasmonate sulfotransferase | |
| 3.1.3.105 | N-acetyl-D-muramate 6-phosphate phosphatase | False | 2 | 61 | 0 | 1 | N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-muramate + phosphate | N-acetyl-D-muramate 6-phosphate phosphohydrolase | None | mupP (gene name) | |
| 3.1.4.58 | RNA 2',3'-cyclic 3'-phosphodiesterase | False | 12 | 21550 | 0 | 6 | (ribonucleotide)n-2',3'-cyclic phosphate + H2O = (ribonucleotide)n-2'-phosphate | (ribonucleotide)n-2',3'-cyclic phosphate 3'-nucleotidohydrolase | None | thpR (gene name); ligT (gene name) | |
| 3.1.7.12 | (+)-kolavelool synthase | False | 1 | 0 | 0 | 1 | (+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate | kolavenyl-diphosphate diphosphohydrolase | None | Haur_2146 | |
| 3.2.1.204 | 1,3-alpha-isomaltosidase | False | 1 | 0 | 0 | 2 | cyclobis-(1->6)-alpha-nigerosyl + 2 H2O = 2 isomaltose (overall reaction);;(1a) cyclobis-(1->6)-alpha-nigerosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose;;(1b) alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose | 1,3-alpha-isomaltohydrolase (configuration-retaining) | None | None | |
| 3.2.1.205 | isomaltose glucohydrolase | False | 1 | 1 | 4 | 1 | isomaltose + H2O = beta-D-glucose + D-glucose | isomaltose 6-alpha-glucohydrolase (configuration-inverting) | None | None | |
| 3.4.19.16 | glucosinolate gamma-glutamyl hydrolase | False | 3 | 2 | 0 | 1 | (1) an (E)-1-(glutathion-S-yl)-N-hydroxy-omega-(methylsulfanyl)alkan-1-imine + H2O = an (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-omega-(methylsulfanyl)alkan-1-imine + L-glutamate;;(2) (E)-1-(glutathion-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + H2O = (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + L-glutamate;;(3) (glutathion-S-yl)(1H-indol-3-yl)acetonitrile + H2O = (L-cysteinylglycin-S-yl)(1H-indol-3-yl)acetonitrile + L-glutamate;;(4) (Z)-1-(glutathion-S-yl)-N-hydroxy-2-phenylethan-1-imine + H2O = (Z)-1-(L-cysteinyglycin-S-yl)-N-hydroxy-2-phenylethan-1-imine + L-glutamate | None | None | GGP1 (gene name); GGP3 (gene name) | |
| 3.13.1.6 | [CysO sulfur-carrier protein]-S-L-cysteine hydrolase | False | 3 | 24 | 0 | 1 | [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O = [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine | [CysO sulfur-carrier protein]-S-L-cysteine sulfohydrolase | None | mec (gene name) | |
| 4.2.1.172 | trans-4-hydroxy-L-proline dehydratase | False | 1 | 8 | 2 | 1 | trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H2O | trans-4-hydroxy-L-proline hydro-lyase | None | None | |
| 4.2.1.173 | ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase | False | 1 | 0 | 0 | 1 | ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O | geranylgeranyl-diphosphate hydro-lyase (ent-8alpha-hydroxylabd-13-en-15-yl diphosphate-forming) | None | SmCPS4 | |
| 4.2.1.174 | peregrinol diphosphate synthase | False | 2 | 0 | 0 | 1 | peregrinol diphosphate = geranylgeranyl diphosphate + H2O | geranylgeranyl-diphosphate hydro-lyase (peregrinol-diphosphate-forming) | None | MvCPS1 | |
| 4.2.3.157 | (+)-isoafricanol synthase | False | 3 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-isoafricanol-forming] | None | None | |
| 4.2.3.158 | (-)-spiroviolene synthase | False | 1 | 0 | 5 | 5 | geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, (-)-spiroviolene-forming] | None | None | |
| 4.2.3.159 | tsukubadiene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = tsukubadiene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, tsukubadiene-forming) | None | None | |
| 4.2.3.160 | (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase | False | 6 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2S,3R,6S,9S)-(-)-protoillud-7-ene-forming] | None | TPS6 (gene name) | |
| 4.2.3.161 | (3S)-(+)-asterisca-2(9),6-diene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (3S)-(+)-asterisca-2(9),6-diene-forming] | None | TPS2 (gene name) | |
| 4.2.3.162 | (-)-alpha-amorphene synthase | False | 1 | 3 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-amorphene-forming] | None | None | |
| 4.2.3.163 | (+)-corvol ether B synthase | False | 6 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-corvol ether B-forming] | None | None | |
| 4.2.3.164 | (+)-eremophilene synthase | False | 2 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-eremophilene-forming] | None | STC3 (gene name); geoA (gene name) | |
| 4.2.3.165 | (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase | False | 2 | 0 | 0 | 3 | (2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (1R,4R,5S)-(-)-guaia-6,10(14)-diene-forming] | None | STC5 (gene name) | |
| 4.2.3.166 | (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol-forming] | None | None | |
| 4.2.3.167 | dolabella-3,7-dien-18-ol synthase | False | 2 | 0 | 0 | 1 | geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, (3E,7E)-dolabella-3,7-dien-18-ol-forming] | None | TPS20 (gene name) | |
| 4.2.3.168 | dolathalia-3,7,11-triene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, (3E,7E)-dolathalia-3,7,11-triene-forming] | None | TPS20 (gene name) | |
| 4.2.3.169 | 7-epi-alpha-eudesmol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 7-epi-alpha-eudesmol-forming) | None | None | |
| 4.2.3.170 | 4-epi-cubebol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 4-epi-cubebol-forming) | None | None | |
| 4.2.3.171 | (+)-corvol ether A synthase | False | 6 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-corvol ether A-forming] | None | None | |
| 4.2.3.172 | 10-epi-juneol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 10-epi-juneol-forming) | None | None | |
| 4.2.3.173 | tau-cadinol synthase | False | 3 | 2 | 0 | 3 | (2E,6E)-farnesyl diphosphate + H2O = tau-cadinol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, tau-cadinol-forming) | None | None | |
| 4.2.3.174 | (2E,6E)-hedycaryol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2E,6E)-hedycaryol-forming] | None | None | |
| 4.2.3.175 | 10-epi-cubebol synthase | False | 1 | 0 | 1 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 10-epi-cubebol-forming) | None | sce6369 | |
| 4.2.3.176 | sesterfisherol synthase | False | 1 | 0 | 1 | 1 | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = sesterfisherol + diphosphate | (2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, sesterfisherol-forming) | None | NfSS | |
| 4.2.3.177 | beta-thujene synthase | False | 1 | 0 | 0 | 1 | geranyl diphosphate = beta-thujene + diphosphate | geranyl-diphosphate diphosphate-lyase (cyclizing, beta-thujene-forming) | None | CoTPS1 | |
| 4.2.3.178 | stellata-2,6,19-triene synthase | False | 1 | 0 | 0 | 1 | (2E,6E,10E,14E)-geranylfarnesyl diphosphate = stellata-2,6,19-triene + diphosphate | (2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cylizing, stellata-2,6,19-triene-forming) | None | None | |
| 4.2.3.179 | guaia-4,6-diene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = guaia-4,6-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, guaia-4,6-diene-forming) | None | XsTPS2 | |
| 4.2.3.180 | pseudolaratriene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = pseudolaratriene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, pseudolaradiene-forming) | None | PxaTPS8 | |
| 4.2.3.181 | selina-4(15),7(11)-diene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = selina-4(15),7(11)-diene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, selina-4(15),7(11)-diene-forming) | None | SdS | |
| 4.2.3.182 | pristinol synthase | False | 2 | 3 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(2S,3R,9R)-pristinol-forming] | None | None | |
| 4.2.3.183 | nezukol synthase | False | 1 | 1 | 0 | 1 | (+)-copalyl diphosphate + H2O = nezukol + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming) | None | TPS2 | |
| 4.2.3.184 | 5-hydroxy-alpha-gurjunene synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 5-hydroxy-alpha-gurjunene-forming) | None | MpMTPSL4 | |
| 4.2.3.185 | ent-atiserene synthase | False | 2 | 0 | 0 | 2 | ent-copalyl diphosphate = ent-atiserene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-atiserine-forming) | None | IrKSL4; AcKSL1; ApKSL1; AtKSL1; AsKSL1 | |
| 4.2.3.186 | ent-13-epi-manoyl oxide synthase | False | 1 | 0 | 0 | 3 | ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate | ent-8alpha-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (cyclizing, ent-13-epi-manoyl-oxide-forming) | None | SmKSL2; ent-LDPP synthase | |
| 4.2.3.187 | (2Z,6E)-hedycaryol synthase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2Z,6E)-hedycaryol-forming] | None | HcS | |
| 4.2.3.188 | beta-geranylfarnesene synthase | False | 1 | 0 | 0 | 1 | (1) all-trans-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate;;(2) all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate;;(3) all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate | all-trans-geranylfarnesyl-diphosphate diphosphate-lyase (beta-geranylfarnesene-forming) | None | Bcl-TS | |
| 4.2.3.189 | 9,13-epoxylabd-14-ene synthase | False | 2 | 0 | 0 | 1 | peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate | peregrinol-diphosphate diphosphate-lyase [(13R)-9,13-epoxylabd-14-ene-forming] | None | ELS (gene name); TPS2 (gene name) (ambiguous); peregrinol-diphosphate diphosphate-lyase (9,13-epoxylabd-14-ene-forming) | |
| 4.2.3.190 | manoyl oxide synthase | False | 1 | 0 | 0 | 4 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = manoyl oxide + diphosphate | (13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (manoyl-oxide-forming) | None | GrTPS6; CfTPS3; CfTPS4; MvELS | |
| 4.2.3.191 | cycloaraneosene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = cycloaraneosene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cycloaraneosene-forming) | None | SdnA | |
| 4.2.3.192 | labda-7,13(16),14-triene synthase | False | 1 | 0 | 0 | 1 | (13E)-labda-7,13-dienyl diphosphate = labda-7,13(16),14-triene + diphosphate | (13E)-labda-7,13-dienyl-diphosphate diphosphate-lyase (labda-7,13(16),14-triene-forming) | None | SCLAV_p0491 | |
| 4.2.3.193 | (12E)-labda-8(17),12,14-triene synthase | False | 2 | 0 | 3 | 1 | (+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate | (+)-copalyl-diphosphate diphosphate-lyase [(12E)-labda-8(17),12,14-triene-forming] | None | CldD | |
| 4.2.3.194 | (-)-drimenol synthase | False | 3 | 0 | 1 | 2 | (2E,6E)-farnesyl diphosphate + H2O = (-)-drimenol + diphosphate | (2E,6E)-farnesyl-diphosphate diphospho-lyase [cyclising, (-)-drimenol-forming] | None | PhDS; VoTPS3; farnesyl pyrophosphate:drimenol cyclase; drimenol cyclase; (2E,6E)-farnesyl-diphosphate diphosphohydrolase (drimenol-forming) | |
| 4.3.2.7 | glutathione-specific gamma-glutamylcyclotransferase | False | 16 | 13614 | 3 | 4 | glutathione = L-cysteinylglycine + 5-oxo-L-proline | glutathione gamma-glutamyl cyclotransferase (5-oxo-L-proline producing) | None | gamma-GCG; CHAC (gene name); CHAC1 (gene name); CHAC2 (gene name) | |
| 4.3.2.8 | gamma-glutamylamine cyclotransferase | False | 8 | 843 | 0 | 4 | epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline | epsilon-(gamma-L-glutamyl)-L-lysine gamma-glutamyl cyclotransferase (5-oxo-L-proline producing) | None | GGACT | |
| 4.3.2.9 | gamma-glutamylcyclotransferase | False | 9 | 4395 | 0 | 13 | alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline | alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing) | None | gamma-glutamyl-amino acid cyclotransferase; gamma-L-glutamylcyclotransferase; L-glutamic cyclase; (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing); GGCT | |
| 4.4.1.36 | hercynylcysteine S-oxide lyase | False | 0 | 61 | 0 | 3 | S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor (overall reaction);;(1a) S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3;;(1b) 2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O (spontaneous) | S-(hercyn-2-yl)-L-cysteine ergothioneine-hydroxysulfanolate-lyase | None | egtE (gene name) | |
| 5.4.4.8 | linalool isomerase | False | 1 | 0 | 0 | 1 | (RS)-linalool = geraniol | (RS)-linalool hydroxymutase | None | 3,1-hydroxyl-Delta1-Delta2-mutase (linalool isomerase) | |
| 5.4.99.65 | pre-alpha-onocerin synthase | False | 1 | 0 | 0 | 1 | (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin | (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene mutase (cyclizing, pre-alpha-onocerin-forming) | None | LCC | |
| 5.4.99.66 | alpha-onocerin synthase | False | 1 | 0 | 0 | 1 | pre-alpha-onocerin = alpha-onocerin | pre-alpha-onocerin mutase (cyclizing, alpha-onocerin-forming) | None | LCD | |
| 5.5.1.28 | (-)-kolavenyl diphosphate synthase | False | 4 | 0 | 0 | 1 | geranylgeranyl diphosphate = (-)-kolavenyl diphosphate | (-)-kolavenyl diphosphate lyase (ring-opening) | None | SdKPS; TwTPS14; TwTPS10/KPS; SdCPS2; clerodienyl diphosphate synthase; CLPP | |
| 5.5.1.29 | (+)-kolavenyl diphosphate synthase | False | 2 | 0 | 0 | 1 | geranylgeranyl diphosphate = (+)-kolavenyl diphosphate | (+)-kolavenyl-diphosphate lyase (ring-opening) | None | None | |
| 5.5.1.30 | labda-7,13-dienyl diphosphate synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate | (13E)-labda-7,13-dien-15-yl-diphosphate lyase (ring-opening) | None | SCLAV_p0490 | |
| 6.1.3.1 | olefin beta-lactone synthetase | False | 3 | 10 | 0 | 6 | ATP + a (2R,3S)-2-alkyl-3-hydroxyalkanoate = AMP + diphosphate + a cis-3-alkyl-4-alkyloxetan-2-one | (2R,3S)-2-alkyl-3-hydroxyalkanoate ligase (beta-lactone,AMP-forming) | None | oleC (gene name) | |
| 6.2.1.50 | 4-hydroxybenzoate adenylyltransferase FadD22 | False | 4 | 0 | 0 | 3 | ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] (overall reaction);;(1a) ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate;;(1b) 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | 4-hydroxybenzoate:holo-[4-hydroxyphenylalkanoate synthase] ligase (AMP-forming) | None | fadD22 (gene name); 4-hydroxybenzoate adenylase | |
| 1.2.99.10 | 4,4'-diapolycopenoate synthase | False | 3 | 8 | 0 | 3 | (1) 4,4'-diapolycopen-4-al + H2O + acceptor = 4,4'-diapolycopen-4-oate + reduced acceptor;;(2) 4,4'-diapolycopene-4,4'-dial + 2 H2O + 2 acceptor = 4,4'-diapolycopene-4,4'-dioate + 2 reduced acceptor | 4,4'-diapolycopen-4-al,donor:oxygen oxidoreductase (4,4'-diapolycopen-4-oate-forming) | None | crtNc; 4,4'-diapolycopenealdehyde oxidase (misleading) | |
| 1.3.1.113 | (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase | False | 1 | 2 | 0 | 1 | a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+ | [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl-phosphate:NADP+ oxidoreductase | None | bprA (gene name); scbC (gene name) | |
| 1.3.8.14 | L-prolyl-[peptidyl-carrier protein] dehydrogenase | False | 3 | 44 | 5 | 3 | L-prolyl-[peptidyl-carrier protein] + 2 electron-transfer flavoprotein = 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] + 2 reduced electron-transfer flavoprotein | L-prolyl-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase | None | pigA (gene name); bmp3 (gene name); pltE (gene name); redW (gene name); (L-prolyl)-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase | |
| 1.8.5.8 | eukaryotic sulfide quinone oxidoreductase | False | 3 | 28 | 0 | 5 | hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol | sulfide:glutathione,quinone oxidoreductase | None | SQR; SQOR; SQRDL (gene name) | |
| 1.8.7.3 | ferredoxin:CoB-CoM heterodisulfide reductase | False | 9 | 72 | 0 | 5 | 2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = 2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+ | CoB,CoM:ferredoxin oxidoreductase | None | hdrABC (gene names); hdrA1B1C1 (gene names); hdrA2B2C2 (gene names) | |
| 1.8.98.4 | coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase | False | 3 | 65 | 0 | 1 | 2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB | CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase | None | hdrA2B2C2 (gene names) | |
| 1.8.98.5 | H2:CoB-CoM heterodisulfide,ferredoxin reductase | False | 11 | 98 | 0 | 2 | 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB | CoB,CoM,ferredoxin:H2 oxidoreductase | None | None | |
| 1.8.98.6 | formate:CoB-CoM heterodisulfide,ferredoxin reductase | False | 5 | 93 | 0 | 1 | 2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB | coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase | None | None | |
| 1.13.11.84 | crocetin dialdehyde synthase | False | 1 | 1 | 0 | 4 | zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3beta-hydroxy-beta-cyclocitral (overall reaction);;(1a) zeaxanthin + O2 = 3beta-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral;;(1b) 3beta-hydroxy-8'-apo-beta-carotenal + O2 = crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral | zeaxanthin:oxygen 7',8'-oxidoreductase (bond-cleaving) | None | CCD2; zeaxanthin 7,8-dioxygenase | |
| 1.14.13.239 | carnitine monooxygenase | False | 7 | 1090 | 5 | 3 | L-carnitine + NAD(P)H + H+ + O2 = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD(P)+ + H2O | L-carnitine,NAD(P)H:oxygen oxidoreductase (trimethylamine-forming) | None | cntAB (gene names); yeaWX (gene names) | |
| 1.14.14.55 | quinine 3-monooxygenase | False | 1 | 0 | 0 | 5 | quinine + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH---hemoprotein reductase] + H2O | quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP3A4 (gene name) | |
| 1.14.14.56 | 1,8-cineole 2-exo-monooxygenase | False | 1 | 0 | 0 | 2 | 1,8-cineole + [reduced NADPH---hemoprotein reductase] + O2 = 2-exo-hydroxy-1,8-cineole + [oxidized NADPH---hemoprotein reductase] + H2O | 1,8-cineole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-exo-hydroxylating) | None | CYP3A4 | |
| 1.14.15.24 | beta-carotene 3-hydroxylase | False | 10 | 1583 | 0 | 26 | beta-carotene + 4 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + 2 O2 = zeaxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (overall reaction);;(1a) beta-carotene + 2 reduced ferredoxin [iron-sulfur] cluster + H+ + O2 = beta-cryptoxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) beta-cryptoxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + H+ + O2 = zeaxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | beta-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase | None | beta-carotene 3,3'-monooxygenase; CrtZ | |
| 1.14.99.59 | tryptamine 4-monooxygenase | False | 2 | 0 | 0 | 1 | tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O | tryptamine,hydrogen-donor:oxygen oxidoreductase (4-hydroxylating) | None | PsiH | |
| 2.1.1.345 | psilocybin synthase | True | 0 | 0 | 0 | 1 | 2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = 2 S-adenosyl-L-homocysteine + psilocybin (overall reaction);;(1a) S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate;;(1b) S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate = S-adenosyl-L-homocysteine + psilocybin | S-adenosyl-L-methionine:4-hydroxytryptamine-4-phosphate N,N-dimethyltransferase | None | PsiM | |
| 2.1.3.15 | acetyl-CoA carboxytransferase | False | 980 | 67567 | 0 | 7 | [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA | [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine:acetyl-CoA:carboxytransferase | None | accAD (gene names) | |
| 2.3.2.31 | RBR-type E3 ubiquitin transferase | False | 73 | 35894 | 35 | 3 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine (overall reaction);;(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;;(1b) [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [RBR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type) | None | None | |
| 2.3.2.32 | cullin-RING-type E3 NEDD8 transferase | False | 5 | 45 | 0 | 5 | [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine | [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type) | None | RBX1 (gene name) | |
| 2.4.1.348 | N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase | False | 2 | 2 | 0 | 1 | GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | GDP-alpha-D-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining) | None | WbdC | |
| 2.4.1.349 | mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase | False | 1 | 32 | 0 | 1 | 2 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = 2 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | GDP-alpha-D-mannose:alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining) | None | WbdB | |
| 2.4.1.350 | mogroside IE synthase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-glucose + mogrol = mogroside IE + UDP | UDP-alpha-D-glucose:mogrol 3-O-glucosyltransferase | None | UGT74AC1; mogrol C-3 hydroxyl glycosyltransferase | |
| 2.5.1.142 | nerylneryl diphosphate synthase | False | 1 | 0 | 0 | 4 | prenyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + nerylneryl diphosphate;;(1a) prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + neryl diphosphate;;(1b) neryl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate;;(1c) (2Z,6Z)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + nerylneryl diphosphate | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate cistransferase (adding 3 units of 3-methylbut-3-en-1-yl) | None | CPT2; dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 3 isopentenyl units) | |
| 2.7.1.222 | 4-hydroxytryptamine kinase | False | 2 | 0 | 0 | 1 | ATP + 4-hydroxytryptamine = ADP + 4-hydroxytryptamine 4-phosphate | ATP:4-hydroxytryptamine 4-phosphotransferase | None | PsiK | |
| 2.7.3.13 | glutamine kinase | False | 1 | 0 | 0 | 1 | ATP + L-glutamine + H2O = AMP + phosphate + N5-phospho-L-glutamine | ATP:L-glutamine N5-phosphotransferase | None | None | |
| 3.2.1.206 | oleuropein beta-glucosidase | False | 1 | 0 | 0 | 8 | oleuropein + H2O = oleuropein aglycone + D-glucopyranose | oleuropein 2-beta-D-glucohydrolase | None | OeGLU (gene name) | |
| 4.1.1.105 | L-tryptophan decarboxylase | False | 7 | 36 | 0 | 11 | L-tryptophan = tryptamine + CO2 | L-tryptophan carboxy-lyase | None | psiD (gene name); TDC (gene name) | |
| 4.1.1.106 | fatty acid photodecarboxylase | False | 2 | 0 | 7 | 1 | a long-chain fatty acid + hnu = a long-chain alkane + CO2 | fatty acid carboxy-lyase (light-dependent, alkane-forming) | None | FAP (gene name) | |
| 4.1.1.107 | 3,4-dihydroxyphenylacetaldehyde synthase | False | 6 | 0 | 0 | 3 | L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 | L-dopa carboxy-lyase (oxidative-deaminating) | None | DHPAA synthase | |
| 4.1.1.108 | 4-hydroxyphenylacetaldehyde synthase | False | 2 | 0 | 0 | 2 | L-tyrosine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + CO2 + NH3 + H2O2 | L-tyrosine carboxy-lyase (oxidative-deaminating) | None | TYRDC-2 (gene name) | |
| 4.1.1.109 | phenylacetaldehyde synthase | False | 3 | 0 | 0 | 2 | L-phenylalanine + O2 + H2O = phenylacetaldehyde + CO2 + NH3 + H2O2 | L-phenylalanine carboxy-lyase (oxidative-deaminating) | None | PAAS (gene name) | |
| 4.1.99.23 | 5-hydroxybenzimidazole synthase | False | 8 | 2 | 0 | 2 | 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor | 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole formate-lyase (5-hydroxybenzimidazole-forming) | None | bzaF (gene name); HBI synthase | |
| 4.2.3.195 | rhizathalene A synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = rhizathalene A + diphosphate | geranygeranyl-diphosphate diphosphate-lyase (rhizathalene A-forming) | None | TPS08 (gene name) | |
| 4.99.1.12 | pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase | False | 20 | 2506 | 0 | 1 | Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = pyridinium-3,5-bisthiocarboxylate mononucleotide + Ni2+ | Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide nickel-lyase (pyridinium-3,5-bisthiocarboxylate-mononucleotide-forming) | None | LarC; P2TMN nickel chelatase | |
| 6.2.1.51 | 4-hydroxyphenylalkanoate adenylyltransferase FadD29 | False | 3 | 22 | 0 | 2 | (1) ATP + 17-(4-hydroxyphenyl)heptadecanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase];;(1a) ATP + 17-(4-hydroxyphenyl)heptadecanoate = diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl-adenylate;;(1b) 17-(4-hydroxyphenyl)heptadecanoyl-adenylate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase];;(2) ATP + 19-(4-hydroxyphenyl)nonadecanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase];;(2a) ATP + 19-(4-hydroxyphenyl)nonadecanoate = diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl-adenylate;;(2b) 19-(4-hydroxyphenyl)nonadecanoyl-adenylate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase];; | 4-hydroxyphenylalkanoate:holo-[(phenol)carboxyphthiodiolenone synthase] ligase | None | fadD29 (gene name); 4-hydroxyphenylalkanoate adenylase | |
| 6.2.1.52 | L-firefly luciferin---CoA ligase | True | 0 | 0 | 0 | 4 | ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA | (R)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)thiazole-4-carboxylate:CoA ligase (AMP-forming) | None | LUC | |
| 1.8.2.6 | S-disulfanyl-L-cysteine oxidoreductase | False | 0 | 10 | 0 | 2 | [SoxY protein]-S-disulfanyl-L-cysteine + 6 ferricytochrome c + 3 H2O = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 6 ferrocytochrome c + 6 H+ | [SoxY protein]-S-disulfanyl-L-cysteine:cytochrome-c oxidoreductase | None | SoxCD; sulfur dehydrogenase | |
| 1.13.12.24 | calcium-regulated photoprotein | True | 0 | 0 | 0 | 3 | [apoaequorin] + coelenterazine + O2 + 3 Ca2+ = [excited state blue fluorescent protein] + CO2 (overall reaction);;(1a) [apoaequorin] + coelenterazine = [apoaequorin containing coelenterazine];;(1b) [apoaequorin containing coelenterazine] + O2 = [aequorin];;(1c) [aequorin] + 3 Ca2+ = [aequorin] 1,2-dioxetan-3-one;;(1d) [aequorin] 1,2-dioxetan-3-one = [excited state blue fluorescent protein] + CO2 | coelenterazine:oxygen 2-oxidoreductase (decarboxylating, calcium-dependent) | None | Ca2+-regulated photoprotein; calcium-activated photoprotein; aequorin; obelin; halistaurin; mitrocomin; phialidin; clytin; mnemiopsin; berovin | |
| 1.14.11.58 | ornithine lipid ester-linked acyl 2-hydroxylase | False | 1 | 0 | 0 | 1 | an ornithine lipid + 2-oxoglutarate + O2 = a 2-hydroxyornithine lipid + succinate + CO2 | ornithine lipid,2-oxoglutarate:oxygen oxidoreductase (ester-linked acyl 2-hydroxylase) | None | olsC (gene name) | |
| 1.14.11.59 | 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase | False | 1 | 1 | 0 | 1 | (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + 2-oxoglutarate + O2 = (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + succinate + CO2 + H2O | (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside:oxygen oxidoreductase (7-hydroxylating) | None | BX6 (gene name); DIBOA-Glc dioxygenase | |
| 1.14.14.57 | taurochenodeoxycholate 6alpha-hydroxylase | False | 1 | 1 | 0 | 4 | (1) taurochenodeoxycholate + [reduced NADPH---hemoprotein reductase] + O2 = taurohyocholate + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) lithocholate + [reduced NADPH---hemoprotein reductase] + O2 = hyodeoxycholate + [oxidized NADPH---hemoprotein reductase] + H2O | taurochenodeoxycholate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating) | None | CYP3A4; CYP4A21; taurochenodeoxycholate 6alpha-monooxygenase | |
| 1.14.14.58 | trimethyltridecatetraene synthase | False | 3 | 1 | 0 | 2 | (6E,10E)-geranyllinalool + [reduced NADPH---hemoprotein reductase] + O2 = (3E,7E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene + [oxidized NADPH---hemoprotein reductase] + but-3-en-2-one + 2 H2O | (6E,10E)-geranyllinalool,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP82G1; CYP92C5; CYP92C6; DMNT/TMTT homoterpene synthase | |
| 1.14.14.59 | dimethylnonatriene synthase | False | 2 | 0 | 0 | 2 | (3S,6E)-nerolidol + [reduced NADPH---hemoprotein reductase] + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + [oxidized NADPH---hemoprotein reductase] + but-3-en-2-one + 2 H2O | (3S,6E)-nerolidol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP82G1; CYP92C5; DMNT/TMTT homoterpene synthase | |
| 1.14.14.60 | ferruginol monooxygenase | False | 4 | 0 | 0 | 4 | ferruginol + [reduced NADPH---hemoprotein reductase] + O2 = 11-hydroxyferruginol + [oxidized NADPH---hemoprotein reductase] + H2O | ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxyferruginol-forming) | None | CYP76AH24; CYP76AH3 | |
| 1.14.14.61 | carnosic acid synthase | False | 4 | 0 | 0 | 3 | 11-hydroxyferruginol + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = carnosic acid + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O | 11-hydroxyferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP76AK6; CYP76AK7; CYP76AK8 | |
| 1.14.14.62 | salviol synthase | False | 1 | 0 | 0 | 1 | ferruginol + [reduced NADPH---hemoprotein reductase] + O2 = salviol + [oxidized NADPH---hemoprotein reductase] + H2O | ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (salviol-forming) | None | CYP71BE52 | |
| 1.14.14.63 | beta-amyrin 16beta-monooxygenase | False | 1 | 0 | 0 | 1 | beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = maniladiol + [oxidized NADPH---hemoprotein reductase] + H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (maniladiol-forming) | None | CYP716A141 | |
| 1.14.14.64 | beta-amyrin 6beta-monooxygenase | False | 1 | 0 | 0 | 1 | beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = daturadiol + [oxidized NADPH---hemoprotein reductase] + H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (daturadiol-forming) | None | CYP716E26 | |
| 1.14.14.65 | sugiol synthase | False | 1 | 0 | 1 | 1 | ferruginol + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = sugiol + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O | ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (sugiol-forming) | None | CYP76AH3 | |
| 1.14.14.66 | marmesin synthase | True | 0 | 0 | 0 | 1 | demethylsuberosin + [reduced NADPH---hemoprotein reductase] + O2 = (+)-marmesin + [oxidized NADPH---hemoprotein reductase] + H2O | demethylsuberosin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | None | |
| 1.14.14.67 | 11-hydroxysugiol 20-monooxygenase | False | 1 | 0 | 0 | 1 | 11-hydroxysugiol + [reduced NADPH---hemoprotein reductase] + O2 = 11,20-dihydroxysugiol + [oxidized NADPH---hemoprotein reductase] + H2O | 11-hydroxysugiol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11,20-dihydroxysugiol-forming) | None | CYP76AK1 | |
| 1.14.14.68 | syn-pimaradiene 3-monooxygenase | False | 1 | 0 | 0 | 1 | 9beta-pimara-7,15-diene + [reduced NADPH---hemoprotein reductase] + O2 = 9beta-pimara-7,15-diene-3beta-ol + [oxidized NADPH---hemoprotein reductase] + H2O | 9beta-pimara7,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (9beta-pimara-7,15-diene-3beta-ol-forming) | None | CYP701A8 | |
| 1.14.14.69 | ent-cassadiene hydroxylase | False | 1 | 0 | 0 | 1 | ent-cassa-12,15-diene + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) ent-cassa-12,15-diene + [reduced NADPH---hemoprotein reductase] + O2 = ent-cassa-12,15-dien-2beta-ol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) ent-cassa-12,15-dien-2beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = ent-cassa-12,15-dien-2-one + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1b') ent-cassa-12,15-dien-2beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = ent-cassa-12,15-diene-2beta,3beta-diol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) ent-cassa-12,15-dien-2-one + [reduced NADPH---hemoprotein reductase] + O2 = ent-3beta-hydroxycassa-12,15-dien-2-one + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c') ent-cassa-12,15-diene-2beta,3beta-diol + [reduced NADPH---hemoprotein reductase] + O2 = ent-3beta-hydroxycassa-12,15-dien-2-one + [oxidized NADPH---hemoprotein reductase] + 2 H2O | ent-cassa-12,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ent-3beta-hydroxycassa-12,15-dien-2-one-forming) | None | CYP71Z7 | |
| 1.14.15.25 | p-cymene methyl-monooxygenase | True | 0 | 0 | 0 | 2 | p-cymene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 4-isopropylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | p-cymene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating) | None | cymAa (gene name); cymA (gene name); p-cymene methyl hydroxylase | |
| 1.14.15.26 | toluene methyl-monooxygenase | False | 1 | 0 | 0 | 2 | (1) toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(2) p-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 4-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(3) m-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 3-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | methylbenzene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating) | None | xylM (gene names); ntnM (gene names) | |
| 1.14.19.53 | all-trans-retinol 3,4-desaturase | False | 3 | 3 | 0 | 2 | all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O | all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase | None | CYP27C1 (gene name) | |
| 2.1.1.346 | U6 snRNA m6A methyltransferase | False | 11 | 436 | 6 | 2 | S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA | S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase | None | METTL16 (gene name) | |
| 2.1.1.347 | (+)-O-methylkolavelool synthase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + (+)-kolavelool = S-adenosyl-L-homocysteine + (+)-O-methylkolavelool | S-adenosyl-L-methionine:(+)-kolavelool O-methyltransferase | None | Haur_2147 (locus name) | |
| 2.1.5.1 | sesamin methylene transferase | False | 1 | 0 | 0 | 1 | (1) (+)-sesamin + tetrahydrofolate = (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate;;(2) (+)-demethylpiperitol + tetrahydrofolate = (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate | (+)-sesamin:tetrahydrofolate N-methylenetransferase | None | sesA (gene name) | |
| 2.3.1.266 | [ribosomal protein bS18]-alanine N-acetyltransferase | False | 8 | 15969 | 0 | 3 | acetyl-CoA + an N-terminal L-alanyl-[bS18 protein of 30S ribosome] = CoA + an N-terminal N-acetyl-L-alanyl-[bS18 protein of 30S ribosome] | acetyl-CoA:N-terminal L-alanyl-[bS18 protein of 30S ribosome] N-acetyltransferase | None | rimI (gene name) | |
| 2.3.1.267 | [ribosomal protein uS5]-alanine N-acetyltransferase | False | 5 | 18832 | 0 | 1 | acetyl-CoA + an N-terminal L-alanyl-[uS5 protein of 30S ribosome] = CoA + an N-terminal N-acetyl-L-alanyl-[uS5 protein of 30S ribosome] | acetyl-CoA:N-terminal L-alanyl-[uS5 protein of 30S ribosome] N-acetyltransferase | None | rimJ (gene name) | |
| 2.3.1.268 | ethanol O-acetyltransferase | False | 13 | 0 | 0 | 4 | ethanol + acetyl-CoA = ethyl acetate + CoA | acetyl-CoA:ethanol O-acetyltransferase | None | eat1 (gene name); ethanol acetyltransferase | |
| 2.3.3.20 | acyl-CoA:acyl-CoA alkyltransferase | False | 2 | 8 | 0 | 2 | 2 an acyl-CoA + H2O = a (2R)-2-alkyl-3-oxoalkanoate + 2 CoA | acyl-CoA:acyl-CoA alkyltransferase [(2R)-2-alkyl-3-oxoalkanoate-forming] | None | oleA (gene name) | |
| 2.4.1.351 | rhamnogalacturonan I rhamnosyltransferase | False | 4 | 0 | 0 | 1 | UDP-beta-L-rhamnose + alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl]n = UDP + [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl]n+1 | UDP-beta-L-rhamnose:rhamnogalacturonan I 4-rhamnosyltransferase (configuration-inverting) | None | RRT; RG I rhamnosyltransferase | |
| 2.4.1.352 | glucosylglycerate phosphorylase | False | 3 | 14 | 0 | 2 | 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D-glucopyranose 1-phosphate + D-glycerate | 2-O-(alpha-D-glucopyranosyl)-D-glycerate:phosphate alpha-D-glucosyltransferase (configuration-retaining) | None | None | |
| 2.6.1.114 | 8-demethyl-8-aminoriboflavin-5'-phosphate synthase | False | 1 | 2 | 0 | 1 | L-glutamate + FMN + O2 + H2O + 3 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + CO2 + 3 reduced acceptor (overall reaction);;(1a) FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O;;(1b) 8-demethyl-8-formylriboflavin 5'-phosphate + H2O + acceptor = 8-carboxy-8-demethylriboflavin 5'-phosphate + reduced acceptor;;(1c) L-glutamate + 8-carboxy-8-demethylriboflavin 5'-phosphate + H2O + 2 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + CO2 + 2 reduced acceptor | L-glutamate:FMN aminotransferase (oxidizing, decarboxylating) | None | rosB (gene name) | |
| 2.7.9.6 | rifampicin phosphotransferase | False | 5 | 8 | 0 | 2 | ATP + rifampicin + H2O = AMP + 21-phosphorifampicin + phosphate | ATP:rifampicin, water 21-O-phosphotransferase | None | rifampin phosphotransferase; RPH | |
| 3.1.1.103 | teichoic acid D-alanine hydrolase | False | 8 | 840 | 0 | 1 | [(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine | teichoic acid D-alanylhydrolase | None | fmtA (gene name) | |
| 3.2.2.31 | adenine glycosylase | False | 17 | 36808 | 12 | 9 | Hydrolyses free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site. | adenine-DNA deoxyribohydrolase (adenine-releasing) | None | mutY (gene name); A/G-specific adenine glycosylase | |
| 3.13.1.7 | carbonyl sulfide hydrolase | False | 1 | 0 | 0 | 3 | carbonyl sulfide + H2O = hydrogen sulfide + CO2 | carbonyl sulfide hydrogen-sulfide-lyase (decarboxylating) | None | COSase; COS hydrolase; cos (gene name) | |
| 5.3.3.21 | Delta3,5-Delta2,4-dienoyl-CoA isomerase | False | 2 | 4 | 0 | 4 | a (3E,5Z)-alka-3,5-dienoyl-CoA = a (2E,4E)-alka-2,4-dienoyl-CoA | (3E,5Z)-alka-3,5-dienoyl-CoA Delta3,5-Delta2,4 isomerase | None | 3,5-tetradecadienoyl-CoA isomerase; DCI1 (gene name) | |
| 6.3.2.52 | jasmonoyl---L-amino acid ligase | False | 5 | 0 | 0 | 3 | ATP + jasmonate + an L-amino acid = AMP + diphosphate + a jasmonoyl-L-amino acid | jasmonate:L-amino acid ligase | None | JAR1 (gene name); JAR4 (gene name); JAR6 (gene name); jasmonoyl---L-amino acid synthetase | |
| 1.7.1.17 | FMN-dependent NADH-azoreductase | False | 287 | 20114 | 1 | 7 | anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD+ = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 NADH + 2 H+ | N,N-dimethyl-1,4-phenylenediamine, anthranilate:NAD+ oxidoreductase | None | azoR (gene name); NADH-azoreductase | |
| 1.13.11.85 | exo-cleaving rubber dioxygenase | True | 0 | 0 | 0 | 6 | cis-1,4-polyisoprene + n O2 = n (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal | cis-1,4-polyisoprene:oxygen dioxygenase [(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal-forming] | None | roxA (gene name); heme-dependent rubber oxygenase (ambiguous) | |
| 1.14.14.70 | ent-sandaracopimaradiene 3-hydroxylase | False | 1 | 0 | 0 | 1 | ent-sandaracopimaradiene + [reduced NADPH---hemoprotein reductase] + O2 = ent-sandaracopimaradien-3beta-ol + [oxidized NADPH---hemoprotein reductase] + H2O | ent-sandaracopimaradiene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ent-sandaracopimaradien-3beta-ol-forming) | None | CYP701A; OsKOL4 | |
| 1.14.14.71 | cucurbitadienol 11-hydroxylase | False | 1 | 0 | 0 | 1 | cucurbitadienol + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 11-oxocucurbitadienol + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) cucurbitadienol + [reduced NADPH---hemoprotein reductase] + O2 = 11-hydroxycucurbitadienol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 11-hydroxycucurbitadienol + [reduced NADPH---hemoprotein reductase] + O2 = 11-oxocucurbitadienol + [oxidized NADPH---hemoprotein reductase] + 2 H2O | cucurbitadienol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-oxocucurbitadienol-forming) | None | CYP87D18 | |
| 1.14.14.72 | drimenol monooxygenase | False | 1 | 0 | 0 | 1 | drimenol + [reduced NADPH---hemoprotein reductase] + O2 = drimendiol + [oxidized NADPH---hemoprotein reductase] + H2O | drimenol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (drimendiol-forming) | None | PhDOX1 | |
| 1.14.19.54 | 1,2-dehydroreticuline synthase | False | 1 | 0 | 0 | 2 | (S)-reticuline + [reduced NADPH---hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-reticuline,[reduced NADPH---hemoprotein reductase]:oxygen 1,2-oxidoreductase | None | STORR; CYP82Y2 (gene name); DRS (gene name) | |
| 1.14.19.55 | 4-hydroxybenzoate brominase (decarboxylating) | False | 2 | 0 | 0 | 2 | (1) 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+ = 2,4-dibromophenol + 2 NADP+ + CO2 + 4 H2O (overall reaction);;(1a) 4-hydroxybenzoate + NADPH + bromide + O2 + H+ = 3-bromo-4-hydroxybenzoate + NADP+ + 2 H2O;;(1b) 3-bromo-4-hydroxybenzoate + NADPH + bromide + O2 + H+ = 2,4-dibromophenol + NADP+ + CO2 + 2 H2O;;(2) 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+ = 3,5-dibromobenzene-1,2-diol + 2 NADP+ + CO2 + 4 H2O (overall reaction);;(2a) 3,4-dihydroxybenzoate + NADPH + bromide + O2 + H+ = 3-bromo-4,5-dihydroxybenzoate + NADP+ + 2 H2O;;(2b) 3-bromo-4,5-dihydroxybenzoate + NADPH + bromide + O2 + H+ = 3,5-dibromobenzene-1,2-diol + NADP+ + CO2 + 2 H2O | 4-hydroxybenzoate:NADPH oxidoreductase (brominating, decarboxylating) | None | bmp5 (gene name) | |
| 1.14.19.56 | 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase | False | 1 | 1 | 0 | 1 | 1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + 2 FADH2 + 2 chloride + 2 O2 = 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + 2 FAD + 4 H2O (overall reaction);;(1a) 1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + FADH2 + chloride + O2 = 5-chloro-1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + FAD + 2 H2O;;(1b) 5-chloro-1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + FADH2 + chloride + O2 = 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL peptidyl-carrier protein] + FAD + 2 H2O | 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein]:FADH2 oxidoreductase (chlorinating) | None | pltA (gene name) | |
| 1.14.19.57 | 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase | False | 1 | 0 | 0 | 1 | 1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + 3 FADH2 + 3 bromide + 3 O2 = 3,4,5-tribromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + 3 FAD + 6 H2O (overall reaction);;(1a) 1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2 = 5-bromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O;;(1b) 5-bromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2 = 4,5-dibromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O;;(1c) 4,5-dibromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FADH2 + bromide + O2 = 3,4,5-tribromo-1H-pyrrole-2-carbonyl-[Bmp1 peptidyl-carrier protein] + FAD + 2 H2O;; | 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein]:FADH2 oxidoreductase (brominating) | None | bmp2 (gene name) | |
| 1.14.19.58 | tryptophan 5-halogenase | False | 1 | 0 | 0 | 3 | L-tryptophan + FADH2 + chloride + O2 + H+ = 5-chloro-L-tryptophan + FAD + 2 H2O | L-tryptophan:FADH2 oxidoreductase (5-halogenating) | None | pyrH (gene name) | |
| 1.14.19.59 | tryptophan 6-halogenase | False | 2 | 0 | 0 | 2 | (1) L-tryptophan + FADH2 + chloride + O2 + H+ = 6-chloro-L-tryptophan + FAD + 2 H2O;;(2) D-tryptophan + FADH2 + chloride + O2 + H+ = 6-chloro-D-tryptophan + FAD + 2 H2O | L-tryptophan:FADH2 oxidoreductase (6-halogenating) | None | sttH (gene name); thdH (gene name) | |
| 1.14.19.60 | 7-chloro-L-tryptophan 6-halogenase | False | 1 | 0 | 0 | 1 | 7-chloro-L-tryptophan + FADH2 + chloride + O2 + H+ = 6,7-dichloro-L-tryptophan + FAD + 2 H2O | 7-chloro-L-tryptophan:FADH2 oxidoreductase (6-halogenating) | None | ktzR (gene name) | |
| 1.14.20.4 | anthocyanidin synthase | False | 10 | 705 | 0 | 31 | a (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O2 = an anthocyanidin + succinate + CO2 + 2 H2O (overall reaction);;(1a) a (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O2 = a (4S)- 2,3-dehydroflavan-3,4-diol + succinate + CO2 + H2O;;(1b) a (4S)- 2,3-dehydroflavan-3,4-diol = an anthocyanidin + H2O | (2R,3S,4S)-leucoanthocyanidin,2-oxoglutarate:oxygen oxidoreductase | None | leucocyanidin oxygenase; leucocyanidin,2-oxoglutarate:oxygen oxidoreductase; ANS (gene name) | |
| 1.14.20.5 | flavone synthase I | False | 1 | 5 | 0 | 6 | a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O | flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) | None | FNSI (gene name) | |
| 1.14.20.6 | flavonol synthase | False | 13 | 345 | 0 | 31 | a dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O | dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase | None | FLS (gene name) | |
| 1.14.20.7 | 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) | False | 6 | 8939 | 0 | 6 | L-arginine + 2-oxoglutarate + O2 = L-glutamate 5-semialdehyde + guanidine + succinate + CO2 (overall reaction);;(1a) L-arginine + 2-oxoglutarate + O2 = 5-hydroxy-L-arginine + succinate + CO2;;(1b) 5-hydroxy-L-arginine = L-glutamate 5-semialdehyde + guanidine | L-arginine,2-oxoglutarate:oxygen oxidoreductase (succinate-forming) | None | ethene-forming enzyme; ethylene-forming enzyme; EFE | |
| 1.14.20.8 | (-)-deoxypodophyllotoxin synthase | False | 1 | 0 | 3 | 1 | (-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O | (-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming) | None | 2-ODD (gene name) | |
| 2.1.1.348 | mRNA m6A methyltransferase | False | 16 | 2450 | 52 | 9 | S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N6-methyladenine in mRNA | S-adenosyl-L-methionine:adenine in mRNA methyltransferase | None | METTL3 (gene name); METTL14 (gene name) | |
| 2.4.1.353 | sordaricin 6-deoxyaltrosyltransferase | False | 1 | 0 | 0 | 1 | GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP | GDP-6-deoxy-alpha-D-altrose:sordaricin 6-deoxy-D-altrosyltransferase | None | SdnJ | |
| 2.4.1.354 | (R)-mandelonitrile beta-glucosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-glucose + (R)-mandelonitrile = UDP + (R)-prunasin | UDP-alpha-D-glucose:(R)-mandelonitrile beta-D-glucosyltransferase (configuration-inverting) | None | UGT85A19 (gene name) | |
| 2.4.1.355 | poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase | False | 2 | 5 | 0 | 1 | n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | None | TarS | |
| 2.4.2.59 | sulfide-dependent adenosine diphosphate thiazole synthase | False | 39 | 2598 | 1 | 5 | NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O | NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding) | None | Thi4 (ambiguous) | |
| 2.4.2.60 | cysteine-dependent adenosine diphosphate thiazole synthase | False | 44 | 1793 | 0 | 11 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O | NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing) | None | THI4 (gene name) (ambiguous); THI1 (gene name); ADP-thiazole synthase | |
| 2.5.1.143 | pyridinium-3,5-biscarboxylic acid mononucleotide synthase | False | 1 | 31 | 6 | 1 | deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide | deamido-NAD+:hydrogencarbonate nicotinate-beta-D-ribonucleotidyltransferase | None | LarB; P2CMN synthase; nicotinic acid adenine dinucleotide carboxylase/hydrolase; NaAD carboxylase/hydrolase | |
| 3.2.1.207 | mannosyl-oligosaccharide alpha-1,3-glucosidase | False | 8 | 2 | 9 | 26 | (1) Glc2Man9GlcNAc2-[protein] + H2O = GlcMan9GlcNAc2-[protein] + beta-D-glucopyranose;;(2) GlcMan9GlcNAc2-[protein] + H2O = Man9GlcNAc2-[protein] + beta-D-glucopyranose | Glc2Man9GlcNAc2-[protein] 3-alpha-glucohydrolase (configuration-inverting) | None | ER glucosidase II; alpha-glucosidase II; trimming glucosidase II; ROT2 (gene name); GTB1 (gene name); GANAB (gene name); PRKCSH (gene name) | |
| 3.5.1.128 | deaminated glutathione amidase | False | 12 | 110 | 0 | 7 | N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine | N-(4-oxoglutaryl)-L-cysteinylglycine amidohydrolase | None | dGSH deaminase; NIT1 (gene name) | |
| 5.3.3.22 | lutein isomerase | False | 12 | 1047 | 0 | 2 | lutein = meso-zeaxanthin | lutein Delta4-Delta5-isomerase | None | RPE65 (gene name); meso-zeaxanthin isomerase | |
| 5.5.1.31 | hapalindole H synthase | True | 0 | 0 | 0 | 1 | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole H-forming) | None | famC2 (gene name); famC3 (gene name) | |
| 5.5.1.32 | 12-epi-hapalindole U synthase | True | 0 | 0 | 0 | 2 | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-hapalindole U-forming) | None | famC1 (gene name); HpiC1 (gene name) | |
| 5.5.1.33 | 12-epi-fischerindole U synthase | True | 0 | 0 | 0 | 2 | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-fischerindole U-forming) | None | fisC (gene name); fimC5 (gene name) | |
| 6.2.1.53 | L-proline---[L-prolyl-carrier protein] ligase | False | 4 | 3 | 3 | 3 | ATP + L-proline + holo-[L-prolyl-carrier protein] = AMP + diphosphate + L-prolyl-[L-prolyl-carrier protein] (overall reaction);;(1a) ATP + L-proline = diphosphate + (L-prolyl)adenylate;;(1b) (L-prolyl)adenylate + holo-[L-prolyl-carrier protein] = AMP + L-prolyl-[L-prolyl-carrier protein] | L-proline:[L-prolyl-carrier protein] ligase (AMP-forming) | None | pltF (gene name); bmp4 (gene name); pigI (gene name) | |
| 6.2.1.54 | D-alanine---[D-alanyl-carrier protein] ligase | False | 72 | 1906 | 2 | 4 | ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein] (overall reaction);;(1a) ATP + D-alanine = (D-alanyl)adenylate + diphosphate;;(1b) (D-alanyl)adenylate + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] | D-alanine:[D-alanyl-carrier protein] ligase | None | dltA (gene name); Dcl | |
| 1.2.1.100 | 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase | False | 1 | 0 | 0 | 3 | 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ | 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase | None | mlr6793 (locus name) | |
| 1.3.1.114 | 3-dehydro-bile acid Delta4,6-reductase | False | 1 | 55 | 0 | 0 | (1) 3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+;;(2) 3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+;;(3) 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+;;(4) 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+;; | 3-oxocholan-24-oyl-CoA Delta4,6-oxidoreductase | None | baiN (gene name) | |
| 1.3.1.115 | 3-oxocholoyl-CoA 4-desaturase | False | 1 | 0 | 0 | 0 | (1) 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+;;(2) 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ | 3-oxocholoyl-CoA Delta4-oxidoreductase | None | baiCD (gene name); 3-oxo-choloyl-CoA dehydrogenase | |
| 1.3.1.116 | 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase | False | 1 | 0 | 0 | 0 | 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ | 7beta-hydroxy-3-oxochol-24-oyl-CoA Delta4-oxidoreductase | None | baiH (gene name) | |
| 1.3.1.117 | hydroxycinnamoyl-CoA reductase | True | 0 | 0 | 0 | 1 | (1) dihydro-4-coumaroyl-CoA + NADP+ = trans-4-coumaroyl-CoA + NADPH + H+;;(2) dihydroferuloyl-CoA + NADP+ = trans-feruloyl-CoA + NADPH + H+ | dihydro-4-coumaroyl-CoA:NADP+ 2,3-oxidoreductase | None | MdHCDBR; hydroxycinnamoyl-CoA double bond reductase | |
| 1.3.99.39 | carotenoid phi-ring synthase | False | 2 | 1 | 0 | 5 | carotenoid beta-end group + 2 acceptor = carotenoid phi-end group + 2 reduced acceptor | carotenoid beta-ring:acceptor oxidoreductase/methyltranferase (phi-ring-forming) | None | crtU (gene name) (ambiguous) | |
| 1.3.99.40 | carotenoid chi-ring synthase | False | 0 | 1 | 0 | 2 | carotenoid beta-end group + 2 acceptor = carotenoid chi-end group + 2 reduced acceptor | carotenoid beta-ring:acceptor oxidoreductase/methyltranferase (chi-ring-forming) | None | crtU (gene name) (ambiguous); cruE (gene name) | |
| 1.14.13.240 | 2-polyprenylphenol 6-hydroxylase | False | 3 | 121 | 0 | 2 | 2-(all-trans-polyprenyl)phenol + NADPH + H+ + O2 = 3-(all-trans-polyprenyl)benzene-1,2-diol + NADP+ + H2O | 2-(all-trans-polyprenyl)phenol,NADPH:oxygen oxidoreductase (6-hydroxylating) | None | ubiI (gene name); ubiM (gene name) | |
| 1.14.13.241 | 5-pyridoxate monooxygenase | True | 0 | 0 | 0 | 2 | 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+ | 5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening) | None | 5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing); 5-pyridoxate oxidase (misleading); 5-pyridoxate dioxygenase (incorrect) | |
| 1.14.13.242 | 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase | False | 0 | 3 | 0 | 2 | 3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 = 2-(acetamidomethylidene)succinate + NAD(P)+ | 3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (ring-opening) | None | MHPCO; 3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing); methylhydroxypyridinecarboxylate oxidase (misleading); 2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase (incorrect); methylhydroxypyridine carboxylate dioxygenase (incorrect); 3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect]; 3-hydroxy-2-methylpyridinecarboxylate dioxygenase (incorrect) | |
| 1.14.14.73 | albendazole monooxygenase (sulfoxide-forming) | False | 2 | 21 | 0 | 5 | (1) albendazole + [reduced NADPH---hemoprotein reductase] + O2 = albendazole S-oxide + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) fenbendazole + [reduced NADPH---hemoprotein reductase] + O2 = fenbendazole S-oxide + [oxidized NADPH---hemoprotein reductase] + H2O | albendazole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (sulfoxide-forming) | None | albendazole sulfoxidase (ambiguous); albendazole hydroxylase (ambiguous); CYP3A4 (gene name); CYP2J2 (gene name); CYP1A2 (gene name) | |
| 1.14.14.74 | albendazole monooxygenase (hydroxylating) | False | 1 | 21 | 0 | 1 | albendazole + [reduced NADPH---hemoprotein reductase] + O2 = hydroxyalbendazole + [oxidized NADPH---hemoprotein reductase] + H2O | albendazole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | None | CYP2J2 (gene name) | |
| 1.14.14.75 | fenbendazole monooxygenase (4'-hydroxylating) | False | 1 | 21 | 0 | 1 | fenbendazole + [reduced NADPH---hemoprotein reductase] + O2 = 4'-hydroxyfenbendazole + [oxidized NADPH---hemoprotein reductase] + H2O | fenbendazole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4'-hydroxylating) | None | CYP2C19 (gene name) | |
| 1.14.14.76 | ent-isokaurene C2/C3-hydroxylase | False | 1 | 1 | 0 | 1 | ent-isokaurene + 2 O2 + 2 [reduced NADPH---hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) ent-isokaurene + O2 + [reduced NADPH---hemoprotein reductase] = ent-isokauren-2beta-ol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) ent-isokauren-2beta-ol + O2 + [reduced NADPH---hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + [oxidized NADPH---hemoprotein reductase] + H2O | ent-isokaurene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ent-isokaurene-2beta,3beta-diol-forming) | None | CYP71Z6; ent-isokaurene C2-hydroxylase | |
| 1.14.14.77 | phenylacetonitrile alpha-monooxygenase | False | 1 | 0 | 0 | 1 | phenylacetonitrile + [reduced NADPH---hemoprotein reductase] + O2 = (R)-mandelonitrile + [oxidized NADPH---hemoprotein reductase] + H2O | phenylacetonitrile,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase [(R)-mandelonitrile-forming] | None | CYP3201B1 (gene name) | |
| 1.14.14.78 | phylloquinone omega-hydroxylase | False | 2 | 0 | 0 | 3 | phylloquinone + [reduced NADPH---hemoprotein reductase] + O2 = omega-hydroxyphylloquinone + [oxidized NADPH---hemoprotein reductase] + H2O | phylloquinone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxyphylloquinone-forming) | None | vitamin K1 omega-hydroxylase; CYP4F2; CYP4F11 | |
| 1.14.14.79 | docosahexaenoic acid omega-hydroxylase | False | 7 | 9 | 0 | 1 | docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O | docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming) | None | CYP4F3B; CYP4V2; docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming) | |
| 1.14.14.80 | long-chain fatty acid omega-monooxygenase | False | 25 | 1 | 0 | 7 | a long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O | long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating) | None | CYP704B1 (gene name); CYP52M1 (gene name); CYP4A (gene name); CYP86A (gene name) | |
| 1.14.14.81 | flavanoid 3',5'-hydroxylase | False | 8 | 23 | 0 | 34 | a flavanone + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = a 3',5'-dihydroxyflavanone + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) a flavanone + [reduced NADPH---hemoprotein reductase] + O2 = a 3'-hydroxyflavanone + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) a 3'-hydroxyflavanone + [reduced NADPH---hemoprotein reductase] + O2 = a 3',5'-dihydroxyflavanone + [oxidized NADPH---hemoprotein reductase] + H2O | flavanone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3',5'-dihydroxylating) | None | flavonoid 3',5'-hydroxylase | |
| 1.14.14.82 | flavonoid 3'-monooxygenase | False | 5 | 60 | 0 | 43 | a flavonoid + [reduced NADPH---hemoprotein reductase] + O2 = a 3'-hydroxyflavonoid + [oxidized NADPH---hemoprotein reductase] + H2O | flavonoid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating) | None | CYP75B1 (gene name); flavonoid 3'-hydroxylase; flavonoid 3-hydroxylase (incorrect); NADPH:flavonoid-3'-hydroxylase (incorrect); flavonoid 3-monooxygenase (incorrect) | |
| 1.14.14.83 | geraniol 8-hydroxylase | False | 2 | 106 | 0 | 6 | geraniol + [reduced NADPH---hemoprotein reductase] + O2 = (6E)-8-hydroxygeraniol + [oxidized NADPH---hemoprotein reductase] + H2O | geraniol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | None | CYP76B6 (gene name); G10H (gene name) | |
| 1.14.14.84 | linalool 8-monooxygenase | False | 1 | 70 | 0 | 2 | linalool + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (6E)-8-oxolinalool + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) linalool + [reduced NADPH---hemoprotein reductase] + O2 = (6E)-8-hydroxylinalool + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) (6E)-8-hydroxylinalool + [reduced NADPH---hemoprotein reductase] + O2 = (6E)-8-oxolinalool + [oxidized NADPH---hemoprotein reductase] + 2 H2O | linalool,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | None | P-450lin; CYP111 | |
| 1.14.14.85 | 7-deoxyloganate 7-hydroxylase | False | 1 | 0 | 0 | 2 | 7-deoxyloganate + [reduced NADPH---hemoprotein reductase] + O2 = loganate + [oxidized NADPH---hemoprotein reductase] + H2O | 7-deoxyloganate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) | None | CYP72A224 (gene name); 7-deoxyloganin 7-hydroxylase (incorrect); 7-deoxyloganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) (incorrect) | |
| 1.14.14.86 | ent-kaurene monooxygenase | False | 6 | 16 | 0 | 18 | ent-kaur-16-ene + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = ent-kaur-16-en-19-oate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) ent-kaur-16-ene + [reduced NADPH---hemoprotein reductase] + O2 = ent-kaur-16-en-19-ol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) ent-kaur-16-en-19-ol + [reduced NADPH---hemoprotein reductase] + O2 = ent-kaur-16-en-19-al + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) ent-kaur-16-en-19-al + [reduced NADPH---hemoprotein reductase] + O2 = ent-kaur-16-en-19-oate + [oxidized NADPH---hemoprotein reductase] + H2O | ent-kaur-16-ene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | None | ent-kaurene oxidase (misleading) | |
| 1.14.14.87 | 2-hydroxyisoflavanone synthase | False | 3 | 6 | 1 | 8 | (1) liquiritigenin + O2 + [reduced NADPH---hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH---hemoprotein reductase];;(2) (2S)-naringenin + O2 + [reduced NADPH---hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH---hemoprotein reductase] | liquiritigenin, [reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating, aryl migration) | None | CYP93C; IFS; isoflavonoid synthase | |
| 1.14.15.27 | beta-dihydromenaquinone-9 omega-hydroxylase | False | 3 | 0 | 0 | 1 | beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 = omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | beta-dihydromenaquinone-9,reduced ferredoxin:oxygen oxidoreductase (omega-hydroxylating) | None | cyp128 (gene name) | |
| 1.14.15.28 | cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] | False | 6 | 13 | 5 | 2 | cholest-4-en-3-one + 6 reduced [2Fe-2S] ferredoxin + 3 O2 = (25R)-3-oxocholest-4-en-26-oate + 6 oxidized [2Fe-2S] ferredoxin + 4 H2O (overall reaction);;(1a) cholest-4-en-3-one + 2 reduced [2Fe-2S] ferredoxin + O2 = (25R)-26-hydroxycholest-4-en-3-one + 2 oxidized [2Fe-2S] ferredoxin + H2O;;(1b) (25R)-26-hydroxycholest-4-en-3-one + 2 reduced [2Fe-2S] ferredoxin + O2 = (25R)-26-oxocholest-4-en-3-one + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O;;(1c) (25R)-26-oxocholest-4-en-3-one + 2 reduced [2Fe-2S] ferredoxin + O2 = (25R)-3-oxocholest-4-en-26-oate + 2 oxidized [2Fe-2S] ferredoxin + H2O | cholest-4-en-3-one,reduced [2Fe-2S] ferredoxin:oxygen oxidoreductase [(25R)-3-oxocholest-4-en-26-oate-forming] | None | CYP142 | |
| 1.14.15.29 | cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] | False | 5 | 184 | 14 | 3 | cholest-4-en-3-one + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = (25S)-3-oxocholest-4-en-26-oate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O (overall reaction);;(1a) cholest-4-en-3-one + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = (25S)-26-hydroxycholest-4-en-3-one + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) (25S)-26-hydroxycholest-4-en-3-one + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = (25S)-26-oxocholest-4-en-3-one + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(1c) (25S)-26-oxocholest-4-en-3-one + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = (25S)-3-oxocholest-4-en-26-oate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;; | cholest-4-en-3-one,[reduced ferredoxin]:oxygen oxidoreductase [(25S)-3-oxocholest-4-en-26-oate-forming] | None | CYP125; CYP125A1; cholest-4-en-3-one 27-monooxygenase (misleading); cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating); cholest-4-en-3-one 26-monooxygenase (ambiguous) | |
| 1.14.15.30 | 3-ketosteroid 9alpha-monooxygenase | False | 10 | 155 | 0 | 9 | androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | androsta-1,4-diene-3,17-dione,[reduced ferredoxin]:oxygen oxidoreductase (9alpha-hydroxylating) | None | KshA; 3-ketosteroid 9alpha-hydroxylase | |
| 1.14.19.61 | dihydrorhizobitoxine desaturase | False | 1 | 1 | 0 | 1 | dihydrorhizobitoxine + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = rhizobitoxine + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | dihydrorhizobitoxine,ferredoxin:oxygen oxidoreductase (3,4 trans-dehydrogenating) | None | rtxC (gene name) | |
| 1.14.20.9 | L-tyrosine isonitrile desaturase | False | 2 | 0 | 0 | 2 | (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O | (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase | None | pvcB (gene name) | |
| 1.14.20.10 | L-tyrosine isonitrile desaturase/decarboxylase | False | 1 | 0 | 0 | 3 | (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 4-[(E)-2-isocyanoethenyl]phenol + succinate + 2 CO2 + H2O | (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating) | None | pvcB (gene name) | |
| 1.14.20.11 | 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase | False | 1 | 0 | 0 | 1 | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating, 3-[(Z)-2-isocyanoethenyl]-1H-indole-forming) | None | ambI3 (gene name); famH3 (gene name); L-tryptophan isonitrile desaturase/decarboxylase (3-[(Z)-2-isocyanoethenyl]-1H-indole-forming) | |
| 1.14.20.12 | 3-[(E)-2-isocyanoethenyl]-1H-indole synthase | True | 0 | 0 | 0 | 1 | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(E)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating, 3-[(E)-2-isocyanoethenyl]-1H-indole-forming) | None | isnB (gene name); L-tryptophan isonitrile desaturase/decarboxylase (3-[(E)-2-isocyanoethenyl]-1H-indole-forming) | |
| 1.14.20.13 | 6beta-hydroxyhyoscyamine epoxidase | False | 0 | 9 | 0 | 6 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2 + H2O | (6S)-6beta-hydroxyhyoscyamine,2-oxoglutarate:oxygen oxidoreductase (epoxide-forming) | None | hydroxyhyoscyamine dioxygenase; (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming) | |
| 1.14.99.60 | 3-demethoxyubiquinol 3-hydroxylase | False | 124 | 9184 | 2 | 7 | 6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol + a reduced acceptor + O2 = 3-demethylubiquinol + acceptor + H2O | 6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol,acceptor:oxygen oxidoreductase (5-hydroxylating) | None | 6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol 5-hydroxylase; COQ7 (gene name); clk-1 (gene name); ubiF (gene name) | |
| 1.18.6.2 | vanadium-dependent nitrogenase | True | 0 | 0 | 0 | 4 | 12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate | ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing, vanadium-dependent) | None | vnfD (gene name); vnfG (gene name); vnfK (gene name) | |
| 2.3.1.269 | apolipoprotein N-acyltransferase | False | 92 | 27750 | 7 | 7 | a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine = a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine | phosphoglyceride:[apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine N-acyltransferase | None | lnt (gene name); Lnt | |
| 2.3.1.270 | lyso-ornithine lipid O-acyltransferase | False | 4 | 6 | 0 | 3 | a lyso-ornithine lipid + an acyl-[acyl-carrier protein] = an ornithine lipid + a holo-[acyl-carrier protein] | Nalpha-[(3R)-hydroxy-acyl]-L-ornithine O-acyltransferase | None | olsA (gene name) | |
| 2.3.1.271 | L-glutamate-5-semialdehyde N-acetyltransferase | False | 2 | 1 | 0 | 16 | acetyl-CoA + L-glutamate 5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde | acetyl-CoA:L-glutamate-5-semialdehyde N-acetyltransferase | None | MPR1 (gene name); MPR2 (gene name) | |
| 2.3.1.272 | 2-acetylphloroglucinol acetyltransferase | True | 0 | 0 | 0 | 1 | 2 2-acetylphloroglucinol = 2,4-diacetylphloroglucinol + phloroglucinol | 2-acetylphloroglucinol C-acetyltransferase | None | MAPG ATase | |
| 2.4.1.356 | glucosyl-dolichyl phosphate glucuronosyltransferase | False | 1 | 10 | 0 | 1 | UDP-alpha-D-glucuronate + an archaeal dolichyl alpha-D-glucosyl phosphate = UDP + an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate | UDP-alpha-D-glucuronate:dolichyl phosphate glucuronosyltransferase (configuration-inverting) | None | aglG (gene name) | |
| 2.4.1.357 | phlorizin synthase | False | 2 | 0 | 0 | 1 | UDP-alpha-D-glucose + phloretin = UDP + phlorizin | UDP-alpha-D-glucose:phloretin 2'-O-D-glucosyltransferase | None | MdPGT1: P2'GT | |
| 2.5.1.144 | S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) | False | 1 | 2 | 0 | 5 | O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate | O-acetyl-L-serine:thiosulfate 2-amino-2-carboxyethyltransferase | None | cysteine synthase B; cysM (gene name); CS26 (gene name) | |
| 2.5.1.145 | phosphatidylglycerol---prolipoprotein diacylglyceryl transferase | False | 536 | 39995 | 0 | 10 | L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine = sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine | L-1-phosphatidyl-sn-glycerol:[prolipoprotein]-L-cysteine diacyl-sn-glyceryltransferase | None | lgt (gene name) | |
| 2.5.1.146 | 3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase | True | 0 | 0 | 0 | 1 | geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate | geranyl-diphosphate:3-[(Z)-2-isocyanoethenyl]-1H-indole geranyltransferase | None | famD2 (gene name) | |
| 2.7.7.100 | SAMP-activating enzyme | False | 0 | 2 | 0 | 1 | ATP + [SAMP]-Gly-Gly = diphosphate + [SAMP]-Gly-Gly-AMP | ATP:[SAMP]-Gly-Gly adenylyltransferase | None | UbaA (ambiguous); SAMP-activating enzyme E1 (ambiguous) | |
| 2.8.5.1 | S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) | False | 1 | 0 | 0 | 1 | O-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate | thiosulfate:3-phospho-L-serine thiosulfotransferase | None | cysK2 (gene name) | |
| 3.1.6.20 | S-sulfosulfanyl-L-cysteine sulfohydrolase | False | 0 | 10 | 0 | 36 | (1) [SoxY protein]-S-sulfosulfanyl-L-cysteine + H2O = [SoxY protein]-S-sulfanyl-L-cysteine + sulfate;;(2) [SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine + H2O = [SoxY protein]-S-disulfanyl-L-cysteine + sulfate | [SoxY protein]-S-sulfosulfanyl-L-cysteine sulfohydrolase | None | SoxB | |
| 4.1.1.110 | bisphosphomevalonate decarboxylase | False | 3 | 1 | 1 | 3 | (R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate | (R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming) | None | mevalonate 3,5-bisphosphate decarboxylase | |
| 4.1.1.111 | siroheme decarboxylase | False | 21 | 9225 | 0 | 4 | siroheme = 12,18-didecarboxysiroheme + 2 CO2 | siroheme carboxy-lyase | None | sirohaem decarboxylase; nirDLHG (gene name); ahbAB (gene name) | |
| 4.4.1.37 | pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase | False | 1 | 27 | 0 | 1 | (1) [LarE]-L-cysteine + pyridin-1-ium-3,5-dicarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + AMP + diphosphate (overall reaction);;(1a) ATP + pyridin-1-ium-3,5-dicarboxylate mononucleotide = diphosphate + 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate;;(1b) 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine;;(1c) [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide;;(2) [LarE]-L-cysteine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide + AMP + diphosphate (overall reaction);;(2a) ATP + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide = diphosphate + 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate;;(2b) 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine;;(2c) [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide | [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine pyridin-1-ium-3,5-dicarbothioate-mononucleotide-lyase (ATP-consuming) | None | LarE; P2CMN sulfurtransferase; pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase; P2TMN synthase | |
| 6.2.1.55 | E1 SAMP-activating enzyme | True | 0 | 0 | 0 | 1 | ATP + [SAMP]-Gly-Gly + [E1 SAMP-activating enzyme]-L-cysteine = S-[[SAMP]-Gly-Gly]-[[E1 SAMP-activating enzyme]-L-cysteine] + AMP + diphosphate (overall reaction);;(1a) ATP + [SAMP]-Gly-Gly = diphosphate + [SAMP]-Gly-Gly-AMP;;(1b) [SAMP]-Gly-Gly-AMP + [E1 SAMP-activating enzyme]-L-cysteine = S-[[SAMP]-Gly-Gly]-[[E1 SAMP-activating enzyme]-L-cysteine] + AMP | [SAMP]:[E1 SAMP-activating enzyme] ligase (AMP-forming) | None | UbaA; SAMP-activating enzyme E1 | |
| 1.14.14.88 | isoflavone 3'-hydroxylase | False | 1 | 6 | 0 | 3 | formononetin + [reduced NADPH---hemoprotein reductase] + O2 = calycosin + [oxidized NADPH---hemoprotein reductase] + H2O | formononetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating) | None | isoflavone 3'-monooxygenase; CYP81E9 | |
| 1.14.14.89 | 4'-methoxyisoflavone 2'-hydroxylase | False | 1 | 1 | 0 | 5 | formononetin + [reduced NADPH---hemoprotein reductase] + O2 = 2'-hydroxyformononetin + [oxidized NADPH---hemoprotein reductase] + H2O | formononetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating) | None | CYP81E1 (gene name); CYP81E3 (gene name); CYP81E7 (gene name); isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous) | |
| 1.14.14.90 | isoflavone 2'-hydroxylase | False | 1 | 19 | 0 | 6 | an isoflavone + [reduced NADPH---hemoprotein reductase] + O2 = a 2'-hydroxyisoflavone + [oxidized NADPH---hemoprotein reductase] + H2O | isoflavone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating) | None | isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3 | |
| 1.14.14.91 | trans-cinnamate 4-monooxygenase | False | 19 | 606 | 0 | 46 | trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O | trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating) | None | cinnamic acid 4-hydroxylase; CA4H; cytochrome P450 cinnamate 4-hydroxylase; cinnamate 4-hydroxylase; cinnamate 4-monooxygenase; cinnamate hydroxylase; cinnamic 4-hydroxylase; cinnamic acid 4-monooxygenase; cinnamic acid p-hydroxylase; t-cinnamic acid hydroxylase; trans-cinnamate 4-hydroxylase; trans-cinnamic acid 4-hydroxylase; CYP73A1 (gene name) | |
| 1.14.14.92 | benzoate 4-monooxygenase | False | 2 | 3 | 0 | 7 | benzoate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxybenzoate + [oxidized NADPH---hemoprotein reductase] + H2O | benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating) | None | benzoic acid 4-hydroxylase; benzoate 4-hydroxylase; benzoic 4-hydroxylase; benzoate-p-hydroxylase; p-hydroxybenzoate hydroxylase; CYP53A1 (gene name) | |
| 1.14.14.93 | 3,9-dihydroxypterocarpan 6a-monooxygenase | False | 1 | 30 | 0 | 1 | (6aR,11aR)-3,9-dihydroxypterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + [oxidized NADPH---hemoprotein reductase] + H2O | (6aR,11aR)-3,9-dihydroxypterocarpan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6a-hydroxylating) | None | 3,9-dihydroxypterocarpan 6a-hydroxylase; 3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous); CYP93A1 (gene name) | |
| 1.14.14.94 | leukotriene-B4 20-monooxygenase | False | 5 | 4 | 0 | 4 | (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH---hemoprotein reductase] + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH---hemoprotein reductase] + H2O | (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating) | None | leukotriene-B4 20-hydroxylase; leucotriene-B4 omega-hydroxylase; LTB4 20-hydroxylase; LTB4 omega-hydroxylase; CYP4F2 (gene name); CYP4F3 (gene name) | |
| 1.14.14.95 | germacrene A hydroxylase | False | 6 | 3 | 0 | 5 | (+)-germacrene A + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = germacra-1(10),4,11(13)-trien-12-oate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) (+)-germacrene A + O2 + [reduced NADPH---hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) germacra-1(10),4,11(13)-trien-12-ol + O2 + [reduced NADPH---hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) germacra-1(10),4,11(13)-trien-12-al + O2 + [reduced NADPH---hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH---hemoprotein reductase] + H2O | (+)-germacrene-A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating) | None | GAO (gene name) | |
| 1.14.14.96 | 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase | False | 0 | 9 | 0 | 2 | trans-5-O-(4-coumaroyl)-D-quinate + [reduced NADPH---hemoprotein reductase] + O2 = trans-5-O-caffeoyl-D-quinate + [oxidized NADPH---hemoprotein reductase] + H2O | trans-5-O-(4-coumaroyl)-D-quinate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating) | None | 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase; CYP98A3 (gene name) | |
| 1.14.14.97 | methyltetrahydroprotoberberine 14-monooxygenase | False | 1 | 2 | 0 | 1 | (1) (S)-cis-N-methylcanadine + [reduced NADPH---hemoprotein reductase] + O2 = allocryptopine + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) (S)-cis-N-methylstylopine + [reduced NADPH---hemoprotein reductase] + O2 = protopine + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-cis-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-hydroxylating) | None | methyltetrahydroprotoberberine 14-hydroxylase; (S)-cis-N-methyltetrahydroberberine 14-monooxygenase; (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase; CYP82N4 (gene name); (S)-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-hydroxylating); (S)-cis-N-methylstylopine 14-hydroxylase | |
| 1.14.14.98 | protopine 6-monooxygenase | False | 2 | 4 | 0 | 6 | protopine + [reduced NADPH---hemoprotein reductase] + O2 = 6-hydroxyprotopine + [oxidized NADPH---hemoprotein reductase] + H2O | protopine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) | None | protopine 6-hydroxylase; CYP82N2 (gene name) | |
| 1.14.14.99 | (S)-limonene 3-monooxygenase | False | 4 | 0 | 0 | 3 | (S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-trans-isopiperitenol + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating) | None | (-)-limonene 3-hydroxylase; (-)-limonene 3-monooxygenase; CYP71D15 (gene name) | |
| 1.14.14.100 | dihydrosanguinarine 10-monooxygenase | True | 0 | 0 | 0 | 1 | dihydrosanguinarine + [reduced NADPH---hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH---hemoprotein reductase] + H2O | dihydrosanguinarine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating) | None | dihydrosanguinarine 10-hydroxylase | |
| 1.14.14.101 | dihydrochelirubine 12-monooxygenase | True | 0 | 0 | 0 | 1 | dihydrochelirubine + [reduced NADPH---hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + [oxidized NADPH---hemoprotein reductase] + H2O | dihydrochelirubine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating) | None | dihydrochelirubine 12-hydroxylase | |
| 1.14.14.102 | N-methylcoclaurine 3'-monooxygenase | False | 4 | 7 | 0 | 7 | (S)-N-methylcoclaurine + [reduced NADPH---hemoprotein reductase] + O2 = (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-N-methylcoclaurine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating) | None | N-methylcoclaurine 3'-hydroxylase; CYP80B1 (gene name) | |
| 1.14.14.103 | tabersonine 16-hydroxylase | False | 2 | 6 | 0 | 1 | tabersonine + [reduced NADPH---hemoprotein reductase] + O2 = 16-hydroxytabersonine + [oxidized NADPH---hemoprotein reductase] + H2O | tabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (16-hydroxylating) | None | tabersonine-11-hydroxylase; T11H; CYP71D12 (gene name) | |
| 1.14.14.104 | vinorine hydroxylase | True | 0 | 0 | 0 | 1 | vinorine + [reduced NADPH---hemoprotein reductase] + O2 = vomilenine + [oxidized NADPH---hemoprotein reductase] + H2O | vinorine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (21alpha-hydroxylating) | None | None | |
| 1.14.14.105 | taxane 10beta-hydroxylase | False | 1 | 2 | 0 | 3 | taxa-4(20),11-dien-5alpha-yl acetate + [reduced NADPH---hemoprotein reductase] + O2 = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + [oxidized NADPH---hemoprotein reductase] + H2O | taxa-4(20),11-dien-5alpha-yl acetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10beta-hydroxylating) | None | CYP725A1 (gene name); 5-alpha-taxadienol-10-beta-hydroxylase | |
| 1.14.14.106 | taxane 13alpha-hydroxylase | False | 1 | 2 | 0 | 2 | taxa-4(20),11-dien-5alpha-ol + [reduced NADPH---hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha,13alpha-diol + [oxidized NADPH---hemoprotein reductase] + H2O | taxa-4(20),11-dien-5alpha-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (13alpha-hydroxylating) | None | CYP725A2 (gene name) | |
| 1.14.14.107 | ent-kaurenoic acid monooxygenase | False | 4 | 6 | 0 | 20 | ent-kaur-16-en-19-oate + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = gibberellin A12 + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) ent-kaur-16-en-19-oate + [reduced NADPH---hemoprotein reductase] + O2 = ent-7alpha-hydroxykaur-16-en-19-oate + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) ent-7alpha-hydroxykaur-16-en-19-oate + [reduced NADPH---hemoprotein reductase] + O2 = gibberellin A12 aldehyde + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) gibberellin A12 aldehyde + [reduced NADPH---hemoprotein reductase] + O2 = gibberellin A12 + [oxidized NADPH---hemoprotein reductase] + H2O | ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | None | KAO1 (gene name); CYP88A3 (gene name); ent-kaurenoic acid oxidase | |
| 1.14.14.108 | 2,5-diketocamphane 1,2-monooxygenase | False | 2 | 12 | 0 | 1 | (+)-bornane-2,5-dione + FMNH2 + O2 = (+)-5-oxo-1,2-campholide + FMN + H2O | (+)-bornane-2,5-dione,FMNH2:oxygen oxidoreductase (1,2-lactonizing) | None | 2,5-diketocamphane lactonizing enzyme; ketolactonase I (ambiguous); 2,5-diketocamphane 1,2-monooxygenase oxygenating component; 2,5-DKCMO; camP (gene name); camphor 1,2-monooxygenase; camphor ketolactonase I | |
| 1.14.14.109 | 3-hydroxyindolin-2-one monooxygenase | False | 1 | 7 | 0 | 1 | 3-hydroxyindolin-2-one + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one [oxidized NADPH---hemoprotein reductase] + H2O | 3-hydroxyindolin-2-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming) | None | BX4 (gene name); CYP71C1 (gene name) | |
| 1.14.14.110 | 2-hydroxy-1,4-benzoxazin-3-one monooxygenase | True | 0 | 0 | 0 | 1 | 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + [reduced NADPH---hemoprotein reductase] + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + [oxidized NADPH---hemoprotein reductase] + H2O | 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | BX5 (gene name); CYP71C3 (gene name) | |
| 1.14.14.111 | 9beta-pimara-7,15-diene oxidase | False | 1 | 0 | 0 | 1 | 9beta-pimara-7,15-diene + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) 9beta-pimara-7,15-diene + O2 + [reduced NADPH---hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 9beta-pimara-7,15-dien-19-ol + O2 + [reduced NADPH---hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) 9beta-pimara-7,15-dien-19-al + O2 + [reduced NADPH---hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + [oxidized NADPH---hemoprotein reductase] + H2O;; | 9beta-pimara-7,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen 19-oxidoreductase | None | CYP99A3; 9beta-pimara-7,15-diene monooxygenase | |
| 1.14.14.112 | ent-cassa-12,15-diene 11-hydroxylase | False | 2 | 1 | 0 | 1 | ent-cassa-12,15-diene + O2 + [reduced NADPH---hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + [oxidized NADPH---hemoprotein reductase] + H2O | ent-cassa-12,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen 11-oxidoreductase | None | ent-cassadiene C11alpha-hydroxylase; CYP76M7 | |
| 1.14.14.113 | alpha-humulene 10-hydroxylase | False | 1 | 2 | 0 | 1 | alpha-humulene + O2 + [reduced NADPH---hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH---hemoprotein reductase] + H2O | alpha-humulene,[reduced NADPH---hemoprotein reductase]:oxygen 10-oxidoreductase | None | CYP71BA1 | |
| 1.14.14.114 | amorpha-4,11-diene 12-monooxygenase | False | 1 | 2 | 0 | 4 | amorpha-4,11-diene + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = artemisinate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) amorpha-4,11-diene + O2 + [reduced NADPH---hemoprotein reductase] = artemisinic alcohol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) artemisinic alcohol + O2 + [reduced NADPH---hemoprotein reductase] = artemisinic aldehyde + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) artemisinic aldehyde + O2 + [reduced NADPH---hemoprotein reductase] = artemisinate + [oxidized NADPH---hemoprotein reductase] + H2O | amorpha-4,11-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating) | None | CYP71AV1 | |
| 1.14.14.115 | 11-oxo-beta-amyrin 30-oxidase | False | 2 | 84 | 0 | 2 | 11-oxo-beta-amyrin + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = glycyrrhetinate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) 11-oxo-beta-amyrin + O2 + [reduced NADPH---hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 30-hydroxy-11-oxo-beta-amyrin + O2 + [reduced NADPH---hemoprotein reductase] = glycyrrhetaldehyde + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) glycyrrhetaldehyde + O2 + [reduced NADPH---hemoprotein reductase] = glycyrrhetinate + [oxidized NADPH---hemoprotein reductase] + H2O | 11-oxo-beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (30-hydroxylating) | None | CYP72A; CYP72A154; 11-oxo-beta-amyrin 30-monooxygenase | |
| 1.14.14.116 | averantin hydroxylase | False | 2 | 1 | 0 | 1 | (1) (1'S)-averantin + [reduced NADPH---hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) (1'S)-averantin + [reduced NADPH---hemoprotein reductase] + O2 = (1'S,5'R)-5'-hydroxyaverantin + [oxidized NADPH---hemoprotein reductase] + H2O | (1'S)-averantin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating) | None | AVN hydroxylase; avnA (gene name); CYP60A1 | |
| 1.14.14.117 | aflatoxin B synthase | False | 4 | 0 | 0 | 2 | (1) 8-O-methylsterigmatocystin + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = aflatoxin B1 + 2 [oxidized NADPH---hemoprotein reductase] + H2O + methanol + CO2;;(2) 8-O-methyldihydrosterigmatocystin + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = aflatoxin B2 + 2 [oxidized NADPH---hemoprotein reductase] + H2O + methanol + CO2 | 8-O-methylsterigmatocystin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (aflatoxin-B-forming) | None | ordA (gene name) | |
| 1.14.14.118 | tryprostatin B 6-hydroxylase | False | 3 | 0 | 0 | 1 | tryprostatin B + [reduced NADPH---hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH---hemoprotein reductase] + H2O | tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming) | None | ftmC (gene name) | |
| 1.14.14.119 | fumitremorgin C monooxygenase | False | 3 | 0 | 0 | 1 | fumitremorgin C + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O | fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming) | None | ftmG (gene name) | |
| 1.14.14.120 | dammarenediol 12-hydroxylase | False | 1 | 1 | 0 | 2 | dammarenediol-II + [reduced NADPH---hemoprotein reductase] + O2 = protopanaxadiol + [oxidized NADPH---hemoprotein reductase] + H2O | dammarenediol-II,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12beta-hydroxylating) | None | protopanaxadiol synthase; CYP716A47 | |
| 1.14.14.121 | protopanaxadiol 6-hydroxylase | False | 1 | 12 | 0 | 3 | protopanaxadiol + [reduced NADPH---hemoprotein reductase] + O2 = protopanaxatriol + [oxidized NADPH---hemoprotein reductase] + H2O | protopanaxadiol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating) | None | protopanaxatriol synthase; P6H; CYP716A53v2 | |
| 1.14.14.122 | oryzalexin E synthase | False | 2 | 0 | 0 | 1 | ent-sandaracopimaradien-3beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = oryzalexin E + [oxidized NADPH---hemoprotein reductase] + H2O | ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin-E-forming) | None | CYP76M6 | |
| 1.14.14.123 | oryzalexin D synthase | False | 1 | 0 | 0 | 1 | ent-sandaracopimaradien-3beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = oryzalexin D + [oxidized NADPH---hemoprotein reductase] + H2O | ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin-D-forming) | None | CYP76M8 | |
| 1.14.14.124 | dihydromonacolin L hydroxylase | False | 3 | 0 | 0 | 2 | dihydromonacolin L acid + O2 + [reduced NADPH---hemoprotein reductase] = monacolin L acid + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) dihydromonacolin L acid + O2 + [reduced NADPH---hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 3alpha-hydroxy-3,5-dihydromonacolin L acid = monacolin L acid + H2O (spontaneous) | dihydromonacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating) | None | LovA (ambiguous) | |
| 1.14.14.125 | monacolin L hydroxylase | False | 3 | 0 | 0 | 1 | monacolin L acid + O2 + [reduced NADPH---hemoprotein reductase] = monacolin J acid + [oxidized NADPH---hemoprotein reductase] + H2O | monacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | None | LovA (ambiguous) | |
| 1.14.14.126 | beta-amyrin 28-monooxygenase | False | 8 | 11 | 0 | 11 | beta-amyrin + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = oleanolate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) beta-amyrin + O2 + [reduced NADPH---hemoprotein reductase] = erythrodiol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) erythrodiol + O2 + [reduced NADPH---hemoprotein reductase] = oleanolic aldehyde + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) oleanolic aldehyde + O2 + [reduced NADPH---hemoprotein reductase] = oleanolate + [oxidized NADPH---hemoprotein reductase] + H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (28-hydroxylating) | None | CYP716A52v2; CYP716A12; CYP16A75; beta-amyrin 28-oxidase | |
| 1.14.14.127 | methyl farnesoate epoxidase | False | 1 | 0 | 0 | 8 | methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O | methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP15A1 | |
| 1.14.14.128 | farnesoate epoxidase | False | 1 | 0 | 0 | 1 | (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O | (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP15C1 | |
| 1.14.14.129 | long-chain acyl-CoA omega-monooxygenase | False | 1 | 0 | 0 | 1 | (1) oleoyl-CoA + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxyoleoyl-CoA + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) linoleoyl-CoA + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxylinoleoyl-CoA + [oxidized NADPH---hemoprotein reductase] + H2O | long-chain acyl-CoA,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating) | None | long-chain acyl-CoA omega-hydroxylase; CYP86A22 (gene name) | |
| 1.14.14.130 | laurate 7-monooxygenase | False | 4 | 16 | 0 | 2 | dodecanoate + [reduced NADPH---hemoprotein reductase] + O2 = 7-hydroxydodecanoate + [oxidized NADPH---hemoprotein reductase] + H2O | dodecanoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7-hydroxylating) | None | CYP703A2 (gene name) | |
| 1.14.14.131 | bursehernin 5'-monooxygenase | False | 1 | 0 | 0 | 1 | (-)-bursehernin + [reduced NADPH---hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH---hemoprotein reductase] + H2O | (-)-bursehernin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating) | None | CYP71CU1 (gene name); bursehernin 5'-hydroxylase | |
| 1.14.14.132 | (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase | False | 1 | 0 | 0 | 1 | (-)-4'-demethyldeoxypodophyllotoxin + [reduced NADPH---hemoprotein reductase] + O2 = (-)-4'-demethylepipodophyllotoxin + [oxidized NADPH---hemoprotein reductase] + H2O | (-)-deoxypodophyllotoxin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating) | None | CYP82D61 (gene name) | |
| 1.14.14.133 | 1,8-cineole 2-endo-monooxygenase | False | 1 | 20 | 0 | 1 | 1,8-cineole + [reduced flavodoxin] + O2 = 2-endo-hydroxy-1,8-cineole + [oxidized flavodoxin] + H2O | 1,8-cineole,[reduced flavodoxin]:oxygen oxidoreductase (2-endo-hydroxylating) | None | P450cin; CYP176A; CYP176A1 | |
| 1.14.14.134 | beta-amyrin 24-hydroxylase | False | 1 | 2 | 0 | 1 | (1) beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 24-hydroxy-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) sophoradiol + [reduced NADPH---hemoprotein reductase] + O2 = 24-hydroxysophoradiol + [oxidized NADPH---hemoprotein reductase] + H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (24-hydroxylating) | None | sophoradiol 24-hydroxylase; CYP93E1 | |
| 1.14.14.135 | glyceollin synthase | True | 0 | 0 | 0 | 1 | (1) (6aS,11aS)-3,6a,9-trihydroxy-2-prenylpterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin II + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(2) (6aS,11aS)-3,6a,9-trihydroxy-2-prenylpterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin III + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(3) (6aS,11aS)-3,6a,9-trihydroxy-4-prenylpterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin I + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (6aS,11aS)-3,6a,9-trihydroxy-2-prenylpterocarpan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (cyclizing) | None | dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase | |
| 1.14.14.136 | deoxysarpagine hydroxylase | True | 0 | 0 | 0 | 1 | 10-deoxysarpagine + [reduced NADPH---hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH---hemoprotein reductase] + H2O | 10-deoxysarpagine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating) | None | DOSH | |
| 1.14.14.137 | (+)-abscisic acid 8'-hydroxylase | False | 12 | 48 | 0 | 14 | (+)-abscisate + [reduced NADPH---hemoprotein reductase] + O2 = 8'-hydroxyabscisate + [oxidized NADPH---hemoprotein reductase] + H2O | abscisate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8'-hydroxylating) | None | (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase; CYP707A1 (gene name) | |
| 1.14.14.138 | lithocholate 6beta-hydroxylase | False | 1 | 0 | 0 | 2 | lithocholate + [reduced NADPH---hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + [oxidized NADPH---hemoprotein reductase] + H2O | lithocholate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6beta-hydroxylating) | None | lithocholate 6beta-monooxygenase; CYP3A10; 6beta-hydroxylase; cytochrome P450 3A10; lithocholic acid 6beta-hydroxylase | |
| 1.14.14.139 | 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase | False | 4 | 0 | 0 | 5 | (1) 5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH---hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH---hemoprotein reductase] + H2O;; (2) 7alpha-hydroxycholest-4-en-3-one + [reduced NADPH---hemoprotein reductase] + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + [oxidized NADPH---hemoprotein reductase] + H2O;; (3) chenodeoxycholate + [reduced NADPH---hemoprotein reductase] + O2 = cholate + [oxidized NADPH---hemoprotein reductase] + H2O | 5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating) | None | 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase; sterol 12alpha-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase; 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase; chenodeoxycholate 12alpha monooxygenase | |
| 1.14.14.141 | psoralen synthase | False | 3 | 21 | 0 | 5 | (+)-marmesin + [reduced NADPH---hemoprotein reductase] + O2 = psoralen + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O | (+)-marmesin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP71AJ1 | |
| 1.14.14.142 | 8-dimethylallylnaringenin 2'-hydroxylase | True | 0 | 0 | 0 | 1 | sophoraflavanone B + [reduced NADPH---hemoprotein reductase] + O2 = leachianone G + [oxidized NADPH---hemoprotein reductase] + H2O | sophoraflavanone-B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating) | None | 8-DMAN 2'-hydroxylase | |
| 1.14.14.143 | (+)-menthofuran synthase | False | 1 | 3 | 0 | 3 | (+)-pulegone + [reduced NADPH---hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH---hemoprotein reductase] + H2O | (+)-pulegone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (9-hydroxylating) | None | menthofuran synthase; (+)-pulegone 9-hydroxylase; (+)-MFS; cytochrome P450 menthofuran synthase | |
| 1.14.14.144 | abieta-7,13-diene hydroxylase | True | 0 | 0 | 0 | 2 | abieta-7,13-diene + [reduced NADPH---hemoprotein reductase] + O2 = abieta-7,13-dien-18-ol + [oxidized NADPH---hemoprotein reductase] + H2O | abieta-7,13-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating) | None | abietadiene hydroxylase (ambiguous) | |
| 1.14.14.145 | abieta-7,13-dien-18-ol hydroxylase | False | 1 | 91 | 0 | 4 | abieta-7,13-dien-18-ol + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = abieta-7,13-dien-18-oate + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) abieta-7,13-dien-18-ol + [reduced NADPH---hemoprotein reductase] + O2 = abieta-7,13-dien-18,18-diol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O (spontaneous);;(1c) abieta-7,13-dien-18-al + [reduced NADPH---hemoprotein reductase] + O2 = abieta-7,13-dien-18-oate + [oxidized NADPH---hemoprotein reductase] + H2O | abieta-7,13-dien-18-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating) | None | CYP720B1; PtAO; abietadienol hydroxylase (ambiguous) | |
| 1.14.14.146 | geranylgeraniol 18-hydroxylase | True | 0 | 0 | 0 | 3 | geranylgeraniol + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH---hemoprotein reductase] + H2O | geranylgeraniol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating) | None | GGOH-18-hydroxylase | |
| 1.14.14.147 | 22alpha-hydroxysteroid 23-monooxygenase | False | 3 | 22 | 0 | 1 | (1) 3-epi-6-deoxocathasterone + [reduced NADPH---hemoprotein reductase] + O2 = 6-deoxotyphasterol + [oxidized NADPH---hemoprotein reductase] + H2O;;(2) (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + [reduced NADPH---hemoprotein reductase] + O2 = 3-dehydro-6-deoxoteasterone + [oxidized NADPH---hemoprotein reductase] + H2O | 22alpha-hydroxysteroid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (C-23-hydroxylating) | None | cytochrome P450 90C1; CYP90D1; CYP90C1; 3-epi-6-deoxocathasterone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (C-23-hydroxylating); 3-epi-6-deoxocathasterone 23-monooxygenase | |
| 1.14.14.148 | angelicin synthase | False | 1 | 4 | 0 | 1 | (+)-columbianetin + [reduced NADPH---hemoprotein reductase] + O2 = angelicin + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O | (+)-columbianetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | CYP71AJ4 (gene name) | |
| 1.14.14.149 | 5-epiaristolochene 1,3-dihydroxylase | False | 1 | 4 | 0 | 2 | 5-epiaristolochene + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = capsidiol + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O | 5-epiaristolochene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (1- and 3-hydroxylating) | None | 5-epi-aristolochene 1,3-dihydroxylase; EAH; CYP71D20 | |
| 1.14.14.150 | costunolide synthase | False | 3 | 38 | 0 | 5 | germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = (+)-costunolide + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = (+)-costunolide + H2O (spontaneous) | germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating) | None | CYP71BL2 | |
| 1.14.14.151 | premnaspirodiene oxygenase | False | 1 | 64 | 0 | 2 | (-)-vetispiradiene + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = solavetivone + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) (-)-vetispiradiene + [reduced NADPH---hemoprotein reductase] + O2 = solavetivol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) solavetivol + [reduced NADPH---hemoprotein reductase] + O2 = solavetivone + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (-)-vetispiradiene,[reduced NADPH---hemoprotein reductase]:oxygen 2alpha-oxidoreductase | None | HPO; Hyoscymus muticus premnaspirodiene oxygenase; CYP71D55 | |
| 1.14.14.152 | beta-amyrin 11-oxidase | False | 1 | 19 | 0 | 1 | beta-amyrin + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 11-oxo-beta-amyrin + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 11alpha-hydroxy-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 11alpha-hydroxy-beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 11-oxo-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + 2 H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | None | CYP88D6 | |
| 1.14.14.153 | indole-2-monooxygenase | False | 1 | 0 | 0 | 1 | indole + [reduced NADPH---hemoprotein reductase] + O2 = indolin-2-one + [oxidized NADPH---hemoprotein reductase] + H2O | indole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) | None | BX2 (gene name); CYP71C4 (gene name) | |
| 1.14.14.154 | sterol 14alpha-demethylase | False | 32 | 1513 | 3 | 54 | a 14alpha-methylsteroid + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = a Delta14-steroid + formate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) a 14alpha-methylsteroid + [reduced NADPH---hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) a 14alpha-hydroxysteroid + [reduced NADPH---hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) a 14alpha-formylsteroid + [reduced NADPH---hemoprotein reductase] + O2 = a Delta14-steroid + formate + [oxidized NADPH---hemoprotein reductase] + H2O;; | sterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | None | obtusufoliol 14-demethylase; lanosterol 14-demethylase; lanosterol 14alpha-demethylase; sterol 14-demethylase; CYP51 (gene name); ERG11 (gene name) | |
| 1.14.15.31 | 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase | False | 1 | 19 | 0 | 1 | 2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | 2-hydroxy-5-methyl-1-naphthoate,reduced ferredoxin:oxygen oxidoreductase (7-hydroxylating) | None | NcsB3 | |
| 1.14.15.32 | pentalenene oxygenase | False | 1 | 150 | 0 | 1 | pentalenene + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = pentalen-13-al + 4 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O (overall reaction);;(1a) pentalenene + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = pentalen-13-ol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) pentalen-13-ol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = pentalen-13-al + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | pentalenene,reduced ferredoxin:oxygen 13-oxidoreductase | None | PtlI | |
| 1.14.15.33 | pikromycin synthase | False | 1 | 52 | 4 | 3 | (1) narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = pikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(2) narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = neopikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(3) narbomycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = novapikromycin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(4) 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(5) 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(6) 10-deoxymethymycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = novamethymycin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | narbomycin,reduced ferredoxin:oxygen oxidoreductase (pikromycin-forming) | None | PikC; CYP107L1 | |
| 1.14.15.34 | 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase | False | 1 | 1 | 0 | 1 | 20-oxo-5-O-beta-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 5-O-beta-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | 20-oxo-5-O-beta-mycaminosyltylactone,reduced ferredoxin:oxygen oxidoreductase (23-hydroxylating) | None | tylH1 (gene name) | |
| 1.14.15.35 | 6-deoxyerythronolide B hydroxylase | False | 1 | 4 | 0 | 2 | 6-deoxyerythronolide B + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = erythronolide B + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | 6-deoxyerythronolide-B,reduced ferredoxin:oxygen oxidoreductase | None | DEB hydroxylase; eryF (gene name); P450(eryF); CYP107A1 | |
| 1.14.19.62 | secologanin synthase | False | 2 | 54 | 0 | 2 | loganin + [reduced NADPH---hemoprotein reductase] + O2 = secologanin + [oxidized NADPH---hemoprotein reductase] + 2 H2O | loganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ring-cleaving) | None | None | |
| 1.14.19.63 | pseudobaptigenin synthase | True | 0 | 0 | 0 | 1 | (1) calycosin + [reduced NADPH---hemoprotein reductase] + O2 = pseudobaptigenin + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(2) pratensein + [reduced NADPH-hemoprotein reductase] + O2 = 5-hydroxypseudobaptigenin + [oxidized NADPH---hemoprotein reductase] + 2 H2O | calycosin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming) | None | None | |
| 1.14.19.64 | (S)-stylopine synthase | False | 3 | 0 | 0 | 3 | (S)-cheilanthifoline + [reduced NADPH---hemoprotein reductase] + O2 = (S)-stylopine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-cheilanthifoline,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming) | None | (S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) | |
| 1.14.19.65 | (S)-cheilanthifoline synthase | False | 2 | 0 | 0 | 3 | (S)-scoulerine + [reduced NADPH---hemoprotein reductase] + O2 = (S)-cheilanthifoline + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-scoulerine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase [(S)-cheilanthifoline-forming] | None | CYP719A14 (gene name); (S)-scoulerine oxidase (methylenedioxy-bridge-forming) (ambiguous) | |
| 1.14.19.66 | berbamunine synthase | False | 1 | 0 | 0 | 1 | (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH---hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-N-methylcoclaurine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (C-O phenol-coupling) | None | (S)-N-methylcoclaurine oxidase (C-O phenol-coupling) | |
| 1.14.19.67 | salutaridine synthase | False | 1 | 0 | 0 | 7 | (R)-reticuline + [reduced NADPH---hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (R)-reticuline,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (C-C phenol-coupling) | None | (R)-reticuline oxidase (C-C phenol-coupling) | |
| 1.14.19.68 | (S)-canadine synthase | False | 4 | 0 | 0 | 16 | (S)-tetrahydrocolumbamine + [reduced NADPH---hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-tetrahydrocolumbamine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming) | None | (S)-tetrahydroberberine synthase; (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming); CYP719A (gene name) | |
| 1.14.19.69 | biflaviolin synthase | False | 2 | 12 | 0 | 1 | (1) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,3'-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(2) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,8'-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | flaviolin,reduced ferredoxin:oxygen oxidoreductase | None | CYP158A2 (gene name); cytochrome P450 158A2 | |
| 1.14.19.70 | mycocyclosin synthase | False | 2 | 2 | 20 | 1 | cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | cyclo(L-tyrosyl-L-tyrosyl),reduced ferredoxin:oxygen oxidoreductase (diarylbridge-forming) | None | CYP121; rv2276 (locus name) | |
| 1.14.19.71 | fumitremorgin C synthase | False | 3 | 1 | 0 | 1 | tryprostatin A + [reduced NADPH---hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH---hemoprotein reductase] + 2 H2O | tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase | None | ftmE (gene name) | |
| 1.14.19.72 | (-)-pluviatolide synthase | False | 2 | 0 | 0 | 2 | (-)-matairesinol + [reduced NADPH---hemoprotein reductase] + O2 = (-)-pluviatolide + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (-)-matairesinol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming) | None | CYP719A23 (gene name) | |
| 1.14.19.73 | (S)-nandinine synthase | False | 2 | 0 | 0 | 1 | (S)-scoulerine + [reduced NADPH---hemoprotein reductase] + O2 = (S)-nandinine + [oxidized NADPH---hemoprotein reductase] + 2 H2O | (S)-scoulerine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase [(S)-nandinine-forming] | None | CYP719A3 | |
| 1.17.9.1 | 4-methylphenol dehydrogenase (hydroxylating) | False | 1 | 116 | 0 | 6 | 4-methylphenol + 4 oxidized azurin + H2O = 4-hydroxybenzaldehyde + 4 reduced azurin + 4 H+ (overall reaction);;(1a) 4-methylphenol + 2 oxidized azurin + H2O = 4-hydroxybenzyl alcohol + 2 reduced azurin + 2 H+;;(1b) 4-hydroxybenzyl alcohol + 2 oxidized azurin = 4-hydroxybenzaldehyde + 2 reduced azurin + 2 H+ | 4-methylphenol:oxidized azurin oxidoreductase (methyl-hydroxylating) | None | pchCF (gene names); p-cresol-(acceptor) oxidoreductase (hydroxylating); p-cresol methylhydroxylase; 4-cresol dehydrogenase (hydroxylating) | |
| 1.1.1.414 | L-galactonate 5-dehydrogenase | False | 1 | 40 | 0 | 2 | L-galactonate + NAD+ = D-tagaturonate + NADH + H+ | L-galactonate:NAD+ 5-oxidoreductase | None | lgoD (gene name); lgaC (gene name) | |
| 1.13.11.86 | 5-aminosalicylate 1,2-dioxygenase | False | 1 | 0 | 0 | 2 | 5-aminosalicylate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate | 5-aminosalicylate:oxygen 1,2-oxidoreductase (ring-opening) | None | mabB (gene name) | |
| 1.14.14.155 | 3,6-diketocamphane 1,2-monooxygenase | False | 1 | 0 | 0 | 1 | (-)-bornane-2,5-dione + O2 + FMNH2 = (-)-5-oxo-1,2-campholide + FMN + H2O | (-)-bornane-2,5-dione,FMNH2:oxygen oxidoreductase (1,2-lactonizing) | None | 3,6-diketocamphane lactonizing enzyme; 3,6-DKCMO | |
| 1.14.14.156 | tryptophan N-monooxygenase | False | 3 | 6 | 0 | 2 | L-tryptophan + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (E)-indol-3-ylacetaldoxime + 2 [oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O (overall reaction);;(1a) L-tryptophan + [reduced NADPH---hemoprotein reductase] + O2 = N-hydroxy-L-tryptophan + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) N-hydroxy-L-tryptophan + [reduced NADPH---hemoprotein reductase] + O2 = N,N-dihydroxy-L-tryptophan + [oxidized NADPH---hemoprotein reductase] + H2O;;(1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O | L-tryptophan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating) | None | tryptophan N-hydroxylase; CYP79B1; CYP79B2; CYP79B3 | |
| 1.14.14.157 | indolin-2-one monooxygenase | False | 1 | 0 | 0 | 1 | indolin-2-one + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyindolin-2-one + [oxidized NADPH---hemoprotein reductase] + H2O | indolin-2-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating) | None | BX3 (gene name); CYP71C2 (gene name) | |
| 1.14.14.158 | carotenoid epsilon hydroxylase | False | 1 | 2 | 1 | 6 | (1) alpha-carotene + [reduced NADPH-hemoprotein reductase] + O2 = alpha-cryptoxanthin + [oxidized NADPH-hemoprotein reductase] + H2O;; (2) zeinoxanthin + [reduced NADPH-hemoprotein reductase] + O2 = lutein + [oxidized NADPH-hemoprotein reductase] + H2O | alpha-carotene,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating) | None | CYP97C1; LUT1; CYP97C; carotene epsilon-monooxygenase | |
| 1.14.19.74 | (+)-piperitol/(+)-sesamin synthase | False | 2 | 0 | 0 | 2 | (1) (+)-pinoresinol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-piperitol + [oxidized NADPH-hemoprotein reductase] + 2 H2O;;(2) (+)-piperitol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-sesamin + [oxidized NADPH-hemoprotein reductase] + 2 H2O | (+)-pinoresinol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (cyclizing) | None | CYP81Q1; CYP81Q2; PS; PSS; SS; piperitol synthase; sesamin synthase | |
| 1.14.20.14 | hapalindole-type alkaloid chlorinase | True | 0 | 0 | 0 | 2 | (1) hapalindole U + 2-oxoglutarate + O2 + chloride = hapalindole G + succinate + CO2 + H2O;; (2)12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride = 12-epi-fischerindole G + succinate + CO2 + H2O | 12-epi-fischerindole U,2-oxoglutarate:oxygen oxidoreductase (13-halogenating) | None | ambO5 (gene name); welO5 (gene name) | |
| 1.14.20.15 | L-threonyl-[L-threonyl-carrier protein] 4-chlorinase | False | 1 | 2 | 0 | 2 | an L-threonyl-[L-threonyl-carrier protein] + 2-oxoglutarate + O2 + Cl- = a 4-chloro-L-threonyl-[L-threonyl-carrier protein] + succinate + CO2 + H2O | L-threonyl-[L-threonyl-carrier protein],2-oxoglutarate:oxygen oxidoreductase (4-halogenating) | None | syrB2 (gene name) | |
| 1.14.99.61 | cyclooctat-9-en-7-ol 5-monooxygenase | False | 1 | 0 | 0 | 1 | cyclooctat-9-en-7-ol + reduced acceptor + O2 = cyclooctat-9-ene-5,7-diol + acceptor + H2O | cyclooctat-9-en-7-ol,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating) | None | CotB3 | |
| 1.14.99.62 | cyclooctatin synthase | False | 1 | 1 | 0 | 1 | cyclooctat-9-ene-5,7-diol + reduced acceptor + O2 = cyclooctatin + acceptor + H2O | cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating) | None | CotB4 | |
| 1.14.99.63 | beta-carotene 4-ketolase | False | 6 | 5 | 0 | 15 | (1) beta-carotene + 2 reduced acceptor + 2 O2 = echinenone + 2 acceptor + 3 H2O;;(2) echinenone + 2 reduced acceptor + 2 O2 = canthaxanthin + 2 acceptor + 3 H2O | beta-carotene,donor:oxygen oxidoreductase (echinenone-forming) | None | BKT (ambiguous); beta-C-4 oxygenase; beta-carotene ketolase; crtS (gene name); crtW (gene name) | |
| 1.14.99.64 | zeaxanthin 4-ketolase | False | 1 | 0 | 0 | 2 | (1) zeaxanthin + 2 reduced acceptor + 2 O2 = adonixanthin + 2 acceptor + 3 H2O;;(2) adonixanthin + 2 reduced acceptor + 2 O2 = (3S,3'S)-astaxanthin + 2 acceptor + 3 H2O | zeaxanthin,donor:oxygen oxidoreductase (adonixanthin-forming) | None | BKT (ambiguous); crtW148 (gene name) | |
| 1.21.98.4 | PqqA peptide cyclase | False | 49 | 5117 | 0 | 2 | a PqqA peptide + S-adenosyl-L-methionine = a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | PqqA peptide:S-adenosyl-L-methionine oxidoreductase (cyclizing) | None | pqqE (gene name) | |
| 2.1.1.349 | toxoflavin synthase | True | 0 | 0 | 0 | 1 | (1) S-adenosyl-L-methionine + 1,6-didemethyltoxoflavin = S-adenosyl-L-homocysteine + reumycin;;(2) S-adenosyl-L-methionine + reumycin = S-adenosyl-L-homocysteine + toxoflavin | S-adenosyl-L-methionine:1,6-didemethyltoxoflavin N1,N6-dimethyltransferase (toxoflavin-forming) | None | toxA (gene name) | |
| 2.3.1.273 | diglucosylglycerate octanoyltransferase | False | 3 | 9 | 0 | 3 | octanoyl-CoA + 2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate = CoA + 2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate | octanoyl-CoA:2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate octanoyltransferase | None | octT (gene name); DGG octanoyltransferase | |
| 2.4.1.358 | acylphloroglucinol glucosyltransferase | False | 1 | 0 | 0 | 1 | UDP-alpha-D-glucose + 2-acylphloroglucinol = UDP + 2-acylphloroglucinol 1-O-beta-D-glucoside | UDP-alpha-D-glucose:2-acylphloroglucinol 1-O-beta-glucosyltransferase | None | UGT71K3 | |
| 2.5.1.147 | 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase | False | 43 | 6011 | 0 | 3 | 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine | 5-amino-6-(D-ribitylamino)uracil:L-tyrosine, 4-hydroxyphenyl transferase | None | cofH (gene name); cbiF (gene name) (ambiguous) | |
| 2.8.5.2 | L-cysteine S-thiosulfotransferase | False | 10 | 3906 | 0 | 3 | (1) [SoxY protein]-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 2 ferrocytochrome c + 2 H+;;(2) [SoxY protein]-S-sulfanyl-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine + 2 ferrocytochrome c + 2 H+ | thiosulfate:[SoxY protein]-L-cysteine thiosulfonotransferase | None | SoxXA; thiosulfate:[SoxY protein]-L-cysteine thiosulfotransferase | |
| 4.1.1.112 | oxaloacetate decarboxylase | False | 138 | 16728 | 0 | 23 | oxaloacetate = pyruvate + CO2 | oxaloacetate carboxy-lyase (pyruvate-forming) | None | oxaloacetate beta-decarboxylase; oxalacetic acid decarboxylase; oxalate beta-decarboxylase; oxaloacetate carboxy-lyase | |
| 4.1.99.24 | L-tyrosine isonitrile synthase | False | 2 | 0 | 0 | 2 | L-tyrosine + D-ribulose 5-phosphate = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | L-tyrosine:D-ribulose-5-phosphate lyase (isonitrile-forming) | None | pvcA (gene name) | |
| 4.1.99.25 | L-tryptophan isonitrile synthase | False | 2 | 0 | 0 | 3 | L-tryptophan + D-ribulose 5-phosphate = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | L-tryptophan:D-ribulose-5-phosphate lyase (isonitrile-forming) | None | isnA (gene name); ambI1 (gene name); well1 (gene name) | |
| 4.3.1.32 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase | False | 38 | 6918 | 0 | 3 | 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine | 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil ammonia-lyase (7,8-didemethyl-8-hydroxy-5-deazariboflavin-forming) | None | FO synthase; fbiC (gene name) (ambiguous); cofG (gene name) | |
| 4.3.2.10 | imidazole glycerol-phosphate synthase | False | 893 | 71885 | 10 | 8 | 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH3 = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H2O | 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming) | None | IGP synthase; hisFH (gene names); HIS7 (gene name) | |
| 7.1.1.1 | proton-translocating NAD(P)+ transhydrogenase | False | 20 | 63279 | 0 | 6 | NADPH + NAD+ + H+[side 1] = NADP+ + NADH + H+[side 2] | NADPH:NAD+ oxidoreductase (H+-transporting) | None | pntA (gene name); pntB (gene name); NNT (gene name) | |
| 7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) | False | 1385 | 329190 | 192 | 55 | NADH + H+ + an ubiquinone + 4 H+[side 1] = NAD+ + an ubiquinol + 4 H+[side 2] | NADH:ubiquinone oxidoreductase | None | ubiquinone reductase (ambiguous); type 1 dehydrogenase; complex 1 dehydrogenase; coenzyme Q reductase (ambiguous); complex I (electron transport chain); complex I (mitochondrial electron transport); complex I (NADH:Q1 oxidoreductase); dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); DPNH-coenzyme Q reductase (ambiguous); DPNH-ubiquinone reductase (ambiguous); mitochondrial electron transport complex 1; mitochondrial electron transport complex I; NADH coenzyme Q1 reductase; NADH-coenzyme Q oxidoreductase (ambiguous); NADH-coenzyme Q reductase (ambiguous); NADH-CoQ oxidoreductase (ambiguous); NADH-dehydrogenase (ubiquinone) (ambiguous); NADH-CoQ reductase (ambiguous); NADH-ubiquinone reductase (ambiguous); NADH-ubiquinone oxidoreductase (ambiguous); NADH-ubiquinone-1 reductase; reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous); NADH:ubiquinone oxidoreductase complex; NADH-Q6 oxidoreductase (ambiguous); electron transfer complex I; NADH2 dehydrogenase (ubiquinone) | |
| 7.1.2.1 | P-type H+-exporting transporter | False | 33 | 7769 | 4 | 53 | ATP + H2O + H+[side 1] = ADP + phosphate + H+[side 2] | ATP phosphohydrolase (P-type, H+-exporting) | None | proton-translocating ATPase; yeast plasma membrane H+-ATPase; yeast plasma membrane ATPase; ATP phosphohydrolase (ambiguous); proton-exporting ATPase; proton transport ATPase; proton-translocating P-type ATPase; H+-transporting ATPase | |
| 7.1.2.2 | H+-transporting two-sector ATPase | False | 2150 | 138628 | 302 | 122 | ATP + H2O + 4 H+[side 1] = ADP + phosphate + 4 H+[side 2] | ATP phosphohydrolase (two-sector, H+-transporting) | None | ATP synthase; F1-ATPase; FoF1-ATPase; H+-transporting ATPase; mitochondrial ATPase; coupling factors (Fo, F1 and CF1); chloroplast ATPase; bacterial Ca2+/Mg2+ ATPase | |
| 7.1.3.1 | H+-exporting diphosphatase | False | 35 | 17051 | 1 | 44 | diphosphate + H2O + H+[side 1] = 2 phosphate + H+[side 2] | diphosphate phosphohydrolase (H+-transporting) | None | H+-PPase; proton-pumping pyrophosphatase; vacuolar H+-pyrophosphatase; hydrogen-translocating pyrophosphatase; proton-pumping dihosphatase | |
| 7.2.1.1 | NADH:ubiquinone reductase (Na+-transporting) | False | 327 | 37929 | 23 | 27 | NADH + H+ + ubiquinone + n Na+[side 1] = NAD+ + ubiquinol + n Na+[side 2] | NADH:ubiquinone oxidoreductase (Na+-translocating) | None | Na+-translocating NADH-quinone reductase; Na+-NQR | |
| 7.2.1.2 | ferredoxin---NAD+ oxidoreductase (Na+-transporting) | False | 6 | 0 | 0 | 11 | 2 reduced ferredoxin [iron-sulfur] cluster + NAD+ + H+ + Na+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + NADH + Na+[side 2] | ferredoxin:NAD+ oxidoreductase (Na+-transporting) | None | Rnf complex (ambiguous); Na+-translocating ferredoxin:NAD+ oxidoreductase | |
| 7.2.2.1 | Na+-transporting two-sector ATPase | False | 5 | 0 | 7 | 13 | ATP + H2O + n Na+[side 1] = ADP + phosphate + n Na+[side 2] | ATP phosphohydrolase (two-sector, Na+-transporting) | None | sodium-transporting two-sector ATPase; Na+-translocating ATPase; Na+-translocating FoF1-ATPase; sodium ion specific ATP synthase | |
| 7.2.2.2 | ABC-type Cd2+ transporter | False | 2 | 0 | 8 | 9 | ATP + H2O + Cd2+[side 1] = ADP + phosphate + Cd2+[side 2] | ATP phosphohydrolase (ABC-type, heavy-metal-exporting) | None | cadmium-transporting ATPase (ambiguous); ABC-type cadmium-transporter | |
| 7.2.2.3 | P-type Na+ transporter | False | 10 | 3188 | 0 | 45 | ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2] | ATP phosphohydrolase (P-type, Na+-exporting) | None | Na+-exporting ATPase (ambiguous); ENA1 (gene name); ENA2 (gene name); ENA5 (gene name); sodium transport ATPase (ambiguous); sodium-translocating P-type ATPase | |
| 7.2.2.4 | ABC-type Na+ transporter | False | 2 | 0 | 0 | 3 | ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2] | ATP phosphohydrolase (ABC-type, Na+-exporting) | None | natAB (gene names) | |
| 7.2.4.1 | carboxybiotin decarboxylase | False | 1 | 56 | 0 | 3 | a carboxybiotinyl-[protein] + n Na+[side 1] + H+[side 2] = CO2 + a biotinyl-[protein] + n Na+[side 2] (n = 1--2) | carboxybiotinyl-[protein] carboxy-lyase | None | MadB; carboxybiotin protein decarboxylase | |
| 7.2.4.2 | oxaloacetate decarboxylase (Na+ extruding) | False | 34 | 11456 | 2 | 4 | oxaloacetate + 2 Na+[side 1] = pyruvate + CO2 + 2 Na+[side 2] | oxaloacetate carboxy-lyase (pyruvate-forming; Na+-extruding) | None | oxaloacetate beta-decarboxylase (ambiguous); oxalacetic acid decarboxylase (ambiguous); oxalate beta-decarboxylase (ambiguous); oxaloacetate carboxy-lyase (ambiguous) | |
| 7.2.4.3 | (S)-methylmalonyl-CoA decarboxylase (sodium-transporting) | False | 9 | 0 | 0 | 4 | (S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2] | (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming, sodium-transporting) | None | methylmalonyl-coenzyme A decarboxylase (ambiguous); (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect); (S)-methylmalonyl-CoA carboxy-lyase (ambiguous) | |
| 7.3.2.1 | ABC-type phosphate transporter | False | 381 | 0 | 0 | 38 | ATP + H2O + phosphate-[phosphate-binding protein][side 1] = ADP + phosphate + phosphate[side 2] + [phosphate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, phosphate-importing) | None | phosphate ABC transporter; phosphate-transporting ATPase (ambiguous) | |
| 7.3.2.2 | ABC-type phosphonate transporter | False | 132 | 0 | 0 | 1 | ATP + H2O + phosphonate-[phosphonate-binding protein][side 1] = ADP + phosphate + phosphonate[side 2] + [phosphonate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, phosphonate-importing) | None | phosphonate-transporting ATPase (ambiguous) | |
| 7.4.2.1 | ABC-type polar-amino-acid transporter | False | 13 | 1552 | 0 | 37 | ATP + H2O + polar amino acid-[polar amino acid-binding protein][side 1] = ADP + phosphate + polar amino acid[side 2] + [polar amino acid-binding protein][side 1] | ATP phosphohydrolase (ABC-type, polar-amino-acid-importing) | None | histidine permease; polar-amino-acid-transporting ATPase | |
| 7.4.2.2 | ABC-type nonpolar-amino-acid transporter | True | 0 | 0 | 0 | 12 | ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1] = ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1] | ATP phosphohydrolase (ABC-type, nonpolar-amino-acid-importing) | None | nonpolar-amino-acid-transporting ATPase | |
| 7.5.2.1 | ABC-type maltose transporter | False | 27 | 0 | 0 | 12 | ATP + H2O + maltose-[maltose-binding protein][side 1] = ADP + phosphate + maltose[side 2] + [maltose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, maltose-importing) | None | maltose ABC transporter; maltose-transporting ATPase | |
| 7.5.2.2 | ABC-type oligosaccharide transporter | True | 0 | 0 | 0 | 5 | ATP + H2O + oligosaccharide-[oligosaccharide-binding protein][side 1] = ADP + phosphate + oligosaccharide[side 2] + [oligosaccharide-binding protein][side 1] | ATP phosphohydrolase (ABC-type, oligosaccharide-importing) | None | oligosaccharide-transporting ATPase | |
| 7.6.2.1 | P-type phospholipid transporter | False | 83 | 40234 | 73 | 19 | ATP + H2O + phospholipid[side 1] = ADP + phosphate + phospholipid[side 2] | ATP phosphohydrolase (P-type, phospholipid-flipping) | None | Mg2+-ATPase (ambiguous); flippase (ambiguous); aminophospholipid-transporting ATPase (ambiguous); phospholipid-translocating ATPase (ambiguous); phospholipid-transporting ATPase (ambiguous) | |
| 7.6.2.2 | ABC-type xenobiotic transporter | False | 83 | 10217 | 45 | 43 | ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] | ATP phosphohydrolase (ABC-type, xenobiotic-exporting) | None | xenobiotic-transporting ATPase; multidrug-resistance protein; MDR protein; P-glycoprotein; pleiotropic-drug-resistance protein; PDR protein; steroid-transporting ATPase; ATP phosphohydrolase (steroid-exporting) | |
| 7.6.2.3 | ABC-type glutathione-S-conjugate transporter | False | 29 | 4252 | 0 | 8 | ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2] | ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting) | None | multidrug resistance-associated protein 1; glutathione-S-conjugate-translocating ATPase; MRP; MRP1; ABCC1 (gene name); YBT1 (gene name); YCF1 (gene name) | |
| 1.1.1.415 | noscapine synthase | False | 1 | 0 | 0 | 1 | narcotine hemiacetal + NAD+ = noscapine + NADH + H+ | narcotine hemiacetal:NAD+ 1-oxidoreductase | None | NOS (gene name) | |
| 1.2.1.101 | L-tyrosine reductase | False | 2 | 0 | 0 | 1 | L-tyrosinal + NADP+ + AMP + diphosphate = L-tyrosine + NADPH + H+ + ATP | (2S)-2-amino-3-(4-hydroxyphenyl)propanal:NADP+ oxidoreductase (ATP-forming) | None | lnaA (gene name); lnbA (gene name) | |
| 1.3.1.118 | meromycolic acid enoyl-[acyl-carrier-protein] reductase | False | 0 | 1 | 0 | 2 | a meromycolyl-[acyl-carrier protein] + NAD+ = a trans-Delta2-meromycolyl-[acyl-carrier protein] + NADH + H+ | meromycolyl-[acyl-carrier protein]:NAD+ oxidoreductase | None | inhA (gene name) | |
| 1.3.1.119 | chlorobenzene dihydrodiol dehydrogenase | False | 1 | 0 | 0 | 4 | (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ = 3-chlorocatechol + NADH + H+ | (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase | None | tecB (gene name) | |
| 1.5.1.52 | staphylopine dehydrogenase | False | 1 | 1 | 0 | 1 | staphylopine + NADP+ + H2O = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + pyruvate + NADPH + H+ | staphylopine:NADP+ oxidoreductase [(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate]-forming | None | cntM (gene name); staphylopine synthase | |
| 1.13.11.87 | endo-cleaving rubber dioxygenase | False | 0 | 2 | 0 | 6 | Cleavage of cis-1,4-polyisoprene polymers into a mixture of compounds, including a C20 compound ((4Z,8Z,12Z,16Z,20Z,24Z)-4,8,12,16,20,24-hexamethyl-28-oxononacosa-4,8,12,16,20,24-hexaenal), a C25 compound ((4Z,8Z,12Z,16Z,20Z)-4,8,12,16,20-pentamethyl-24-oxopentacosa-4,8,12,16,20-pentaenal), a C30 compound ((4Z,8Z,12Z,16Z)-4,8,12,16-tetramethyl-20-oxohenicosa-4,8,12,16-tetraenal), and larger isoprenologes such as C35, C40, C45, and higher analogues. | cis-1,4-polyisoprene:oxygen dioxygenase (endo-cleaving) | None | latex clearing protein; lcp (gene name); roxB (gene name) | |
| 1.14.11.60 | scopoletin 8-hydroxylase | False | 1 | 0 | 0 | 1 | scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2 | scopoletin,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating) | None | S8H (gene name) | |
| 1.14.12.26 | chlorobenzene dioxygenase | False | 2 | 0 | 0 | 4 | chlorobenzene + NADH + H+ + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ | chlorobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating) | None | TecA | |
| 1.14.14.159 | dolabradiene monooxygenase | False | 1 | 0 | 0 | 1 | (1) dolabradiene + O2 + [reduced NADPH---hemoprotein reductase] = 15,16-epoxydolabrene + H2O + [oxidized NADPH---hemoprotein reductase];;(2) 15,16-epoxydolabrene + O2 + [reduced NADPH---hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H2O + [oxidized NADPH---hemoprotein reductase] | dolabradiene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3beta-hydroxy-15,16-epoxydolabrene-forming) | None | CYP71Z16 (gene name) | |
| 1.14.14.160 | zealexin A1 synthase | False | 1 | 0 | 0 | 1 | (S)-beta-macrocarpene + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = zealexin A1 + 4 H2O + 3 [oxidized NADPH---hemoprotein reductase] (overall reaction);;(1a) (S)-beta-macrocarpene + O2 + [reduced NADPH---hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H2O + [oxidized NADPH---hemoprotein reductase];;(1b) [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl] methanol + O2 + [reduced NADPH---hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + 2 H2O + [oxidized NADPH---hemoprotein reductase];;(1c) (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + [reduced NADPH---hemoprotein reductase] = zealexin A1 + H2O + [oxidized NADPH---hemoprotein reductase] | (S)-beta-macrocarpene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (zealexin A1-forming) | None | CYP71Z18 (gene name) | |
| 1.14.14.161 | nepetalactol monooxygenase | False | 1 | 0 | 0 | 1 | (+)-cis,trans-nepetalactol + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = 7-deoxyloganetate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction);;(1a) (+)-cis,trans-nepetalactol + [reduced NADPH---hemoprotein reductase] + O2 = 7-deoxyloganetic alcohol + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 7-deoxyloganetic alcohol + [reduced NADPH---hemoprotein reductase] + O2 = iridotrial + [oxidized NADPH---hemoprotein reductase] + 2 H2O;;(1c) iridotrial + [reduced NADPH---hemoprotein reductase] + O2 = 7-deoxyloganetate + [oxidized NADPH---hemoprotein reductase] + H2O | (+)-cis,trans-nepetalactol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | None | CYP76A26 (gene name); iridoid oxidase (misleading) | |
| 1.14.14.162 | flavanone 2-hydroxylase | False | 2 | 0 | 0 | 2 | a flavanone + [reduced NADPH---hemoprotein reductase] + O2 = a 2-hydroxyflavanone + [oxidized NADPH---hemoprotein reductase] + H2O | flavanone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) | None | CYP93G2 (gene name); CYP93B1 (gene name); (2S)-flavanone 2-hydroxylase; licodione synthase | |
| 1.14.14.163 | (S)-1-hydroxy-N-methylcanadine 13-hydroxylase | False | 1 | 0 | 0 | 1 | (S)-1-hydroxy-cis-N-methylcanadine + [reduced NADPH---hemoprotein reductase] + O2 = (13S,14R)-1,13-dihydroxy-cis-N-methylcanadine + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-1-hydroxy-cis-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (13-hydroxylating) | None | CYP82X2 (gene name) | |
| 1.14.14.164 | fraxetin 5-hydroxylase | False | 1 | 0 | 0 | 1 | fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O | fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating) | None | CYP82C4; fraxetin 5-monooxygenase | |
| 1.14.14.165 | indole-3-carbonyl nitrile 4-hydroxylase | False | 1 | 0 | 0 | 1 | indole-3-carbonyl nitrile + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH---hemoprotein reductase] + H2O | indole-3-carbonyl nitrile,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating) | None | CYP82C2 | |
| 1.14.19.75 | very-long-chain acyl-lipid omega-9 desaturase | False | 1 | 0 | 0 | 1 | (1) 1-hexacosanoyl-2-acyl-[phosphoglycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = 1-[(17Z)-hexacos-17-enoyl]-2-acyl-[phosphoglycerolipid] + 2 ferricytochrome b5 + 2 H2O;;(2) 1-tetracosanoyl-2-acyl-[phosphoglycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = 1-[(15Z)-tetracos-15-enoyl]-2-acyl-[phosphoglycerolipid] + 2 ferricytochrome b5 + 2 H2O | very-long-chain acyl-[glycerolipid],ferrocytochrome b5:oxygen oxidoreductase (omega9,omega8-cis-dehydrogenating) | None | ADS2 (gene name) | |
| 2.1.1.350 | menaquinone C8-methyltransferase | True | 0 | 0 | 0 | 2 | (1) 2 S-adenosyl-L-methionine + a menaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an 8-methylmenaquinone + oxidized flavodoxin;;(2) 2 S-adenosyl-L-methionine + a 2-demethylmenaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + oxidized flavodoxin | S-adenosyl-L-methionine:menaquinone C8-methyltransferase | None | mqnK (gene name); menK (gene name) | |
| 2.3.1.274 | phosphate acyltransferase | False | 571 | 30286 | 0 | 5 | an acyl-[acyl-carrier protein] + phosphate = an acyl phosphate + an [acyl-carrier protein] | an acyl-[acyl-carrier protein]:phosphate acyltransferase | None | plsX (gene name); acyl-ACP phosphotransacylase; acyl-[acyl-carrier-protein]---phosphate acyltransferase; phosphate-acyl-ACP acyltransferase | |
| 2.3.1.275 | acyl phosphate:glycerol-3-phosphate acyltransferase | False | 461 | 29805 | 1 | 4 | an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycerol 3-phosphate + phosphate | acyl phosphoate:sn-glycerol 3-phosphate acyltransferase | None | plsY (gene name); G3P acyltransferase; GPAT; lysophosphatidic acid synthase; LPA synthase | |
| 2.3.1.276 | galactosamine-1-phosphate N-acetyltransferase | False | 1 | 0 | 0 | 2 | acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + N-acetyl-alpha-D-galactosamine 1-phosphate | acetyl-CoA:alpha-D-galactosamine-1-phosphate N-acetyltransferase | None | ST0452 (locus name) | |
| 2.4.1.359 | glucosylglycerol phosphorylase (configuration-retaining) | False | 1 | 0 | 2 | 1 | 2-O-alpha-D-glucopyranosyl-glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol | 2-O-alpha-D-glucopyranosyl-glycerol:phosphate alpha-D-glucosyltransferase (configuration-retaining) | None | 2-O-alpha-D-glucosylglycerol phosphorylase (retaining) | |
| 2.4.2.61 | alpha-dystroglycan beta1,4-xylosyltransferase | False | 3 | 2 | 0 | 1 | UDP-alpha-D-xylose + 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man]-Ser/Thr-[protein] = UDP + 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man]-Ser/Thr-[protein] | UDP-alpha-D-xylose:3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man]-Ser/Thr-[protein] xylosyltransferase | None | TMEM5 (gene name) | |
| 2.7.1.224 | cytidine diphosphoramidate kinase | False | 1 | 3 | 0 | 1 | ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate | ATP:cytidine 5'-diphosphoramidate 3'-phosphotransferase | None | None | |
| 2.7.7.101 | DNA primase DnaG | False | 123 | 41348 | 0 | 8 | ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate | nucleotide 5'-triphosphate:single-stranded DNA nucleotidyltransferase (DNA-RNA hybrid synthesizing) | None | DnaG | |
| 2.7.7.102 | DNA primase AEP | False | 10 | 2925 | 3 | 9 | (1) ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate;;(2) ssDNA + n dNTP = ssDNA/pppdN(pdN)n-1 hybrid + (n-1) diphosphate | (deoxy)nucleotide 5'-triphosphate:single-stranded DNA (deoxy)nucleotidyltransferase (DNA or DNA-RNA hybrid synthesizing) | None | archaeo-eukaryotic primase; AEP; PrimPol | |
| 2.7.7.103 | L-glutamine-phosphate cytidylyltransferase | False | 1 | 3 | 0 | 1 | CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine | CTP:phosphoglutamine cytidylyltransferase | None | None | |
| 3.1.1.104 | 5-phospho-D-xylono-1,4-lactonase | False | 2 | 0 | 0 | 2 | (1) D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate;;(2) L-arabino-1,4-lactone 5-phosphate + H2O = 5-phospho-L-arabinate | 5-phospho-D-xylono-1,4-lactone hydrolase | None | None | |
| 3.2.1.208 | glucosylglycerate hydrolase | False | 1 | 1 | 0 | 5 | 2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate | 2-O-(alpha-D-glucopyranosyl)-D-glycerate D-glucohydrolase | None | GG hydrolase; GgH | |
| 3.5.1.129 | N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase | False | 1 | 0 | 0 | 1 | N5-(cytidine 5'-diphosphoramidyl)-L-glutamine + H2O = cytidine 5'-diphosphoramidate + L-glutamate | N5-(cytidine 5'-diphosphoramidyl)-L-glutamine amidohydrolase | None | N5-(cytidine 5'-diphosphoramidyl)-L-glutamine deacylase | |
| 4.1.1.113 | trans-aconitate decarboxylase | False | 1 | 0 | 0 | 1 | trans-aconitate = itaconate + CO2 | trans-aconitate carboxy-lyase (itaconate-forming) | None | TAD1 (gene name) | |
| 5.1.3.42 | D-glucosamine-6-phosphate 4-epimerase | False | 3 | 0 | 0 | 1 | D-glucosamine 6-phosphate = D-galactosamine 6-phosphate | D-glucosamine 6-phosphate 4-epimerase | None | ST2245 (locus name) | |
| 5.4.2.13 | phosphogalactosamine mutase | False | 1 | 1 | 0 | 1 | D-galactosamine 6-phosphate = alpha-D-galactosamine-1-phosphate | alpha-D-galactosamine 1,6-phosphomutase | None | ST0242 (locus name) | |
| 7.1.1.3 | ubiquinol oxidase (H+-transporting) | False | 10 | 3297 | 11 | 10 | 2 quinol + O2[side 2] + 8 H+[side 2] = 2 quinone + 2 H2O[side 2] + 8 H+[side 1] | quinol:oxygen oxidoreductase (H+-transporting) | None | cyoABCD (gene names); cytochrome bo3 oxidase; cytochrome bb3 oxidase; cytochrome bo oxidase; Cyo oxidase; ubiquinol:O2 oxidoreductase (H+-transporting); ubiquinol:oxygen oxidoreductase (H+-transporting) | |
| 7.1.1.4 | caldariellaquinol oxidase (H+-transporting) | True | 0 | 0 | 0 | 5 | 2 caldariellaquinol + O2 + n H+[side 1] = 2 caldariellaquinone + 2 H2O + n H+[side 2] | caldariellaquinol:oxygen oxidoreductase (H+-transporting) | None | SoxABCD quinol oxidase; SoxABCD complex; quinol oxidase SoxABCD; SoxM supercomplex; aa3-type quinol oxidase; aa3 quinol oxidase; cytochrome aa3; terminal quinol oxidase; terminal quinol:oxygen oxidoreductase; caldariella quinol:dioxygen oxidoreductase; cytochrome aa3-type oxidase; caldariellaquinol:O2 oxidoreductase (H+-transporting) | |
| 7.1.1.5 | menaquinol oxidase (H+-transporting) | True | 0 | 0 | 0 | 7 | 2 menaquinol + O2 + n H+[side 1] = 2 menaquinone + 2 H2O + n H+[side 2] | menaquinol:oxygen oxidoreductase (H+-transporting) | None | cytochrome aa3-600 oxidase; cytochrome bd oxidase; menaquinol:O2 oxidoreductase (H+-transporting) | |
| 7.1.1.6 | plastoquinol---plastocyanin reductase | False | 55 | 1562 | 5 | 25 | plastoquinol + 2 oxidized plastocyanin + 2 H+[side 1] = plastoquinone + 2 reduced plastocyanin + 4 H+[side 2] | plastoquinol:oxidized-plastocyanin oxidoreductase | None | plastoquinol/plastocyanin oxidoreductase; cytochrome f/b6 complex; cytochrome b6f complex | |
| 7.1.1.7 | quinol oxidase (electrogenic, proton-motive force generating) | False | 11 | 0 | 2 | 14 | 2 quinol + O2[side 2] + 4 H+[side 2] = 2 quinone + 2 H2O[side 2] + 4 H+[side 1] (overall reaction);;(1a) 2 quinol = 2 quinone + 4 H+[side 1] + 4 e- ;;(1b) O2[side 2] + 4 H+[side 2] + 4 e- = 2 H2O[side 2] | quinol:oxygen oxidoreductase (electrogenic, non H+-transporting) | None | cydAB (gene names); appBC (gene names); cytochrome bd oxidase; cytochrome bd-I oxidase; cytochrome bd-II oxidase; ubiquinol:O2 oxidoreductase (electrogenic, non H+-transporting); ubiquinol oxidase (electrogenic, proton-motive force generating); ubiquinol oxidase (electrogenic, non H+-transporting) | |
| 7.1.1.8 | quinol---cytochrome-c reductase | False | 75 | 28776 | 65 | 54 | quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2] | quinol:ferricytochrome-c oxidoreductase | None | ubiquinol---cytochrome-c reductase; coenzyme Q-cytochrome c reductase; dihydrocoenzyme Q-cytochrome c reductase; reduced ubiquinone-cytochrome c reductase; complex III (mitochondrial electron transport); ubiquinone-cytochrome c reductase; ubiquinol-cytochrome c oxidoreductase; reduced coenzyme Q-cytochrome c reductase; ubiquinone-cytochrome c oxidoreductase; reduced ubiquinone-cytochrome c oxidoreductase; mitochondrial electron transport complex III; ubiquinol-cytochrome c-2 oxidoreductase; ubiquinone-cytochrome b-c1 oxidoreductase; ubiquinol-cytochrome c2 reductase; ubiquinol-cytochrome c1 oxidoreductase; CoQH2-cytochrome c oxidoreductase; ubihydroquinol:cytochrome c oxidoreductase; coenzyme QH2-cytochrome c reductase; QH2:cytochrome c oxidoreductase; ubiquinol:ferricytochrome-c oxidoreductase | |
| 7.2.1.3 | ascorbate ferrireductase (transmembrane) | False | 22 | 3945 | 0 | 10 | ascorbate[side 1] + Fe(III)[side 2] = monodehydroascorbate[side 1] + Fe(II)[side 2] | Fe(III):ascorbate oxidorectuctase (electron-translocating) | None | cytochrome b561 (ambiguous) | |
| 7.2.2.5 | ABC-type Mn2+ transporter | False | 1 | 0 | 0 | 6 | ATP + H2O + Mn2+-[manganese-binding protein][side 1] = ADP + phosphate + Mn2+[side 2] + [manganese-binding protein][side 1] | ATP phosphohydrolase (ABC-type, Mn2+-importing) | None | ABC-type manganese permease complex; manganese-transporting ATPase (ambiguous); ABC-type manganese transporter | |
| 7.2.2.6 | P-type K+ transporter | False | 121 | 14100 | 16 | 21 | ATP + H2O + K+[side 1] = ADP + phosphate + K+[side 2] | ATP phosphohydrolase (P-type, K+-importing) | None | K+-translocating Kdp-ATPase; multi-subunit K+-transport ATPase; K+-transporting ATPase; potassium-importing ATPase; K+-importing ATPase | |
| 7.2.2.7 | ABC-type Fe3+ transporter | False | 41 | 0 | 0 | 17 | ATP + H2O + Fe3+-[iron-binding protein][side 1] = ADP + phosphate + Fe3+[side 2] + [iron-binding protein][side 1] | ATP phosphohydrolase (ABC-type, Fe3+-transporting) | None | Fe3+-transporting ATPase | |
| 7.2.2.8 | P-type Cu+ transporter | False | 60 | 15799 | 10 | 19 | ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2] | ATP phosphohydrolase (P-type, Cu+-exporting) | None | Cu+-exporting ATPase (ambiguous); copA (gene name); ATP7A (gene name); ATP7B (gene name) | |
| 7.2.2.9 | P-type Cu2+ transporter | False | 12 | 453 | 0 | 24 | ATP + H2O + Cu2+[side 1] = ADP + phosphate + Cu2+[side 2] | ATP phosphohydrolase (P-type, Cu2+-exporting) | None | Cu2+-exporting ATPase; copB (gene name) | |
| 7.2.2.10 | P-type Ca2+ transporter | False | 95 | 35342 | 30 | 42 | ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2] | ATP phosphohydrolase (P-type, Ca2+-transporting) | None | sarcoplasmic reticulum ATPase; sarco(endo)plasmic reticulum Ca2+-ATPase; calcium pump; Ca2+-pumping ATPase; plasma membrane Ca-ATPase; Ca2+-transporting ATPaseP- | |
| 7.2.2.11 | ABC-type Ni2+ transporter | False | 50 | 7006 | 0 | 3 | ATP + H2O + Ni2+-[nickel-binding protein][side 1] = ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1] | ATP phosphohydrolase (ABC-type, Ni2+-importing) | None | nickel ABC transporter; nickel-transporting ATPase; ABC-type nickel-transporter | |
| 7.2.2.12 | P-type Zn2+ transporter | False | 14 | 1276 | 0 | 20 | ATP + H2O + Zn2+[side 1] = ADP + phosphate + Zn2+[side 2] | ATP phosphohydrolase (P-type, Zn2+-exporting) | None | Zn(II)-translocating P-type ATPase; Zn2+-exporting ATPase; P1B-type ATPase; HMA4 (gene name); zntA (gene name) | |
| 7.2.2.13 | Na+/K+-exchanging ATPase | False | 41 | 875 | 22 | 68 | ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1] | ATP phosphohydrolase (P-type, Na+/K+-exchanging) | None | (Na+ + K+)-activated ATPase; Na,K-activated ATPase; Na,K-pump; Na+,K+-ATPase; sodium/potassium-transporting ATPase; Na+/K+-exchanging ATPase | |
| 7.2.2.14 | P-type Mg2+ transporter | False | 7 | 9633 | 0 | 28 | ATP + H2O + Mg2+[side 1] = ADP + phosphate + Mg2+[side 2] | ATP phosphohydrolase (P-type, Mg2+-importing) | None | Mg2+-transporting P-type ATPase; Mg2+-transporting ATPase; Mg2+-importing ATPase; magnesium-translocating P-type ATPase; mgtA (gene name); mgtB (gene name) | |
| 7.2.2.15 | P-type Ag+ transporter | False | 1 | 0 | 0 | 8 | ATP + H2O + Ag+[side 1] = ADP + phosphate + Ag+[side 2] | ATP phosphohydrolase (P-type, Ag+-exporting) | None | Ag+-exporting ATPase | |
| 7.2.2.16 | ABC-type ferric hydroxamate transporter | False | 2 | 0 | 1 | 5 | ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein][side 1] = ADP + phosphate + Fe3+-hydroxamate complex[side 2] + [hydroxamate-binding protein][side 1] | ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing] | None | iron(III) hydroxamate transporting ATPase; iron(III) hydroxamate ABC transporter; fhuCDB (gene names) | |
| 7.2.2.17 | ABC-type ferric enterobactin transporter | False | 1 | 0 | 0 | 2 | ATP + H2O + Fe3+-enterobactin complex-[enterobactin-binding protein][side 1] = ADP + phosphate + Fe3+-enterobactin complex[side 2] + [enterobactin-binding protein][side 1] | ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing) | None | ferric enterobactin transporting ATPase; ferric enterobactin ABC transporter; fepBCDG (gene names) | |
| 7.2.2.18 | ABC-type ferric citrate transporter | False | 1 | 0 | 0 | 2 | ATP + H2O + Fe3+-dicitrate-[dicitrate-binding protein][side 1] = ADP + phosphate + Fe3+-dicitrate[side 2] + [dicitrate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing) | None | ferric citrate transporting ATPase; ferric citrate ABC transporter; fecBCDE (gene names) | |
| 7.3.2.3 | ABC-type sulfate transporter | False | 68 | 0 | 0 | 7 | ATP + H2O + sulfate-[sulfate-binding protein][side 1] = ADP + phosphate + sulfate[side 2] + [sulfate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, sulfate-importing) | None | sulfate ABC transporter; sulfate-transporting ATPase (ambiguous) | |
| 7.3.2.4 | ABC-type nitrate transporter | False | 4 | 0 | 1 | 24 | ATP + H2O + nitrate-[nitrate-binding protein][side 1] = ADP + phosphate + nitrate[side 2] + [nitrate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, nitrate-importing) | None | nitrate-transporting ATPase (ambiguous) | |
| 7.3.2.5 | ABC-type molybdate transporter | False | 75 | 0 | 0 | 36 | ATP + H2O + molybdate-[molybdate-binding protein][side 1] = ADP + phosphate + molybdate[side 2] + [molybdate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, molybdate-importing) | None | molybdate ABC transporter; molybdate-transporting ATPase | |
| 7.3.2.6 | ABC-type tungstate transporter | False | 8 | 4465 | 0 | 8 | ATP + H2O + tungstate-[tungstate-binding protein][side 1] = ADP + phosphate + tungstate[side 2] + [tungstate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, tungstate-importing) | None | tungstate transporter; tungstate-importing ATPase; tungstate-specific ABC transporter; WtpABC; TupABC | |
| 7.4.2.3 | mitochondrial protein-transporting ATPase | True | 0 | 0 | 0 | 10 | ATP + H2O + mitochondrial-protein[side 1] = ADP + phosphate + mitochondrial-protein[side 2] | ATP phosphohydrolase (mitochondrial protein-importing) | None | None | |
| 7.4.2.4 | chloroplast protein-transporting ATPase | False | 5 | 481 | 0 | 7 | ATP + H2O + chloroplast-protein[side 1] = ADP + phosphate + chloroplast-protein[side 2] | ATP phosphohydrolase (chloroplast protein-importing) | None | None | |
| 7.4.2.5 | bacterial ABC-type protein transporter | False | 13 | 414 | 0 | 31 | ATP + H2O + protein[side 1] = ADP + phosphate + protein[side 2] | ATP phosphohydrolase (ABC-type, peptide-exporting) | None | PrtDEF (gene names); hasDEF (gene names); peptide-transporting ATPase (ambiguous) | |
| 7.4.2.6 | ABC-type oligopeptide transporter | False | 25 | 0 | 3 | 27 | ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1] = ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1] | ATP phosphohydrolase (ABC-type, oligopeptide-importing) | None | oligopeptide permease; OppBCDF; oligopeptide ABC transporter; oligopeptide-transporting ATPase | |
| 7.4.2.7 | ABC-type alpha-factor-pheromone transporter | False | 2 | 0 | 0 | 3 | ATP + H2O + alpha-factor[side 1] = ADP + phosphate + alpha-factor[side 2] | ATP phosphohydrolase (ABC-type, alpha-factor-exporting) | None | alpha-factor-transporting ATPase; alpha-factor-pheromone transporting ATPase | |
| 7.4.2.8 | protein-secreting ATPase | False | 839 | 47872 | 2 | 47 | ATP + H2O + cellular protein[side 1] = ADP + phosphate + cellular protein[side 2] | ATP phosphohydrolase (protein-secreting) | None | None | |
| 7.4.2.9 | ABC-type dipeptide transporter | False | 12 | 5728 | 0 | 9 | ATP + H2O + a dipeptide-[dipeptide-binding protein][side 1] = ADP + phosphate + a dipeptide[side 2] + [dipeptide-binding protein][side 1] | ATP phosphohydrolase (ABC-type, dipeptide-transporting) | None | dipeptide transporting ATPase; dipeptide ABC transporter; dppBCDF (gene names) | |
| 7.5.2.3 | ABC-type beta-glucan transporter | False | 23 | 0 | 4 | 4 | ATP + H2O + beta-glucan[side 1] = ADP + phosphate + beta-glucan[side 2] | ATP phosphohydrolase (ABC-type, beta-glucan-exporting) | None | beta-glucan-transporting ATPase | |
| 7.5.2.4 | ABC-type teichoic-acid transporter | False | 26 | 0 | 1 | 1 | ATP + H2O + teichoic acid[side 1] = ADP + phosphate + teichoic acid[side 2] | ATP phosphohydrolase (ABC-type, teichoic-acid-exporting) | None | teichoic-acid-transporting ATPase | |
| 7.5.2.5 | ABC-type lipopolysaccharide transporter | False | 1 | 0 | 0 | 4 | ATP + H2O + lipopolysaccharide[side 1] = ADP + phosphate + lipopolysaccharide[side 2] | ATP phosphohydrolase (ABC-type, lipopolysaccharide-exporting) | None | lptB (gene name); lipopolysaccharide transport system; lipopolysaccharide-transporting ATPase | |
| 7.5.2.6 | ABC-type lipid A-core oligosaccharide transporter | False | 106 | 0 | 12 | 6 | ATP + H2O + lipid A-core oligosaccharide[side 1] = ADP + phosphate + lipid A-core oligosaccharide[side 2] | ATP phosphohydrolase (ABC-type, lipid A-core oligosaccharide-translocating) | None | MsbA; lipid flippase; ATP-dependent lipid A-core flippase | |
| 7.6.2.4 | ABC-type fatty-acyl-CoA transporter | False | 2 | 0 | 5 | 7 | ATP + H2O + fatty acyl CoA[side 1] = ADP + phosphate + fatty acyl CoA[side 2] | ATP phosphohydrolase (ABC-type, fatty-acyl-CoA-transporting) | None | fatty-acyl-CoA-transporting ATPase | |
| 7.6.2.5 | ABC-type heme transporter | False | 132 | 1561 | 15 | 17 | ATP + H2O + heme[side 1] = ADP + phosphate + heme[side 2] | ATP phosphohydrolase (ABC-type, heme-exporting) | None | heme-transporting ATPase | |
| 7.6.2.6 | ABC-type guanine transporter | False | 3 | 0 | 0 | 1 | ATP + H2O + guanine[side 1] = ADP + phosphate + guanine[side 2] | ATP phosphohydrolase (ABC-type, guanine-importing) | None | guanine-transporting ATPase; white (gene name); brown (gene name) | |
| 7.6.2.7 | ABC-type taurine transporter | False | 46 | 0 | 0 | 2 | ATP + H2O + taurine-[taurine-binding protein][side 1] = ADP + phosphate + taurine[side 2] + [taurine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, taurine-importing) | None | tauABC (gene names); taurine ABC transporter; taurine-transporting ATPase | |
| 7.6.2.8 | ABC-type vitamin B12 transporter | False | 54 | 1331 | 0 | 8 | ATP + H2O + vitamin B12-[cobalamin-binding protein][side 1] = ADP + phosphate + vitamin B12[side 2] + [cobalamin-binding protein][side 1] | ATP phosphohydrolase (ABC-type, vitamin B12-importing) | None | BtuCDF; vitamin B12 ABC transporter; vitamin B12-transporting ATPase | |
| 7.6.2.9 | ABC-type quaternary amine transporter | False | 9 | 14378 | 0 | 10 | ATP + H2O + quaternary amine-[quaternary amine-binding protein][side 1] = ADP + phosphate + quaternary amine[side 2] + [quaternary amine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, quaternary-amine-importing) | None | glycine betaine ABC transporter; ProVWX; quaternary-amine ABC transporter; quaternary-amine-transporting ATPase (ambiguous) | |
| 7.6.2.10 | ABC-type glycerol 3-phosphate transporter | False | 72 | 0 | 0 | 8 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] = ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, sn-glycerol 3-phosphate-importing) | None | glycerol-3-phosphate ABC transporter; glycerol-3-phosphate-transporting ATPase | |
| 7.6.2.11 | ABC-type polyamine transporter | False | 158 | 28254 | 0 | 9 | ATP + H2O + polyamine-[polyamine-binding protein][side 1] = ADP + phosphate + polyamine[side 2] + [polyamine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, polyamine-importing) | None | polyamine ABC transporter; polyamine-transporting ATPase | |
| 4.1.1.114 | cis-3-alkyl-4-alkyloxetan-2-one decarboxylase | False | 2 | 24 | 0 | 1 | a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2 | cis-3-alkyl-4-alkyloxetan-2-one carboxy-lyase (cis-alkene-forming) | None | oleB (gene name) | |
| 1.1.1.416 | isopyridoxal dehydrogenase (5-pyridoxolactone-forming) | True | 0 | 0 | 0 | 1 | isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+ | isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming) | None | None | |
| 1.2.1.102 | isopyridoxal dehydrogenase (5-pyridoxate-forming) | True | 0 | 0 | 0 | 1 | isopyridoxal + NAD+ + H2O = 5-pyridoxate + NADH + H+ | isopyridoxal:NAD+ oxidoreductase (5-pyridoxate-forming) | None | None | |
| 1.14.14.166 | (S)-N-methylcanadine 1-hydroxylase | False | 1 | 0 | 0 | 2 | (S)-cis-N-methylcanadine + [reduced NADPH---hemoprotein reductase] + O2 = (S)-1-hydroxy-cis-N-methylcanadine + [oxidized NADPH---hemoprotein reductase] + H2O | (S)-cis-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (1-hydroxylating) | None | CYP82Y1 (gene name); (S)-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (1-hydroxylating) | |
| 1.14.14.167 | (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase | False | 1 | 0 | 0 | 1 | (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + [reduced NADPH---hemoprotein reductase] + O2 = (13S,14R)-13-O-acetyl-1,8-dihydroxy-cis-N-methylcanadine + [oxidized NADPH---hemoprotein reductase] + H2O | (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine 8-hydroxylase,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | None | CYP82X1 (gene name) | |
| 1.14.14.168 | germacrene A acid 8beta-hydroxylase | False | 2 | 0 | 0 | 2 | germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH---hemoprotein reductase] + H2O | germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8beta-hydroxylating) | None | HaG8H; CYP71BL1; CYP71BL6 | |
| 1.14.14.169 | eupatolide synthase | False | 1 | 0 | 0 | 1 | 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = eupatolide + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate = eupatolide + H2O (spontaneous) | 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating) | None | CYP71DD6; HaES | |
| 1.14.14.170 | 8-epi-inunolide synthase | False | 1 | 0 | 0 | 1 | germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = 8-epi-inunolide + [oxidized NADPH---hemoprotein reductase] + 2 H2O (overall reaction);;(1a) germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH---hemoprotein reductase] + O2 = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = 8-epi-inunolide + H2O (spontaneous) | germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8alpha-hydroxylating) | None | CYP71BL1 | |
| 1.14.19.76 | flavone synthase II | False | 3 | 0 | 0 | 8 | a flavanone + [reduced NADPH---hemoprotein reductase] + O2 = a flavone + [oxidized NADPH---hemoprotein reductase] + 2 H2O | flavanone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (flavone-forming) | None | CYP93B16 (gene name); CYP93G1 (gene name); FNS II | |
| 1.21.4.5 | tetrachlorohydroquinone reductive dehalogenase | False | 1 | 0 | 0 | 2 | (1) 2,6-dichlorohydroquinone + Cl- + glutathione disulfide = 2,3,6-trichlorohydroquinone + 2 glutathione;;(2) 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione | glutathione disulfide:2,6-dichlorohydroquinone (chlorinating) | None | pcpC (gene name) | |
| 2.1.1.351 | nocamycin O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + nocamycin E = S-adenosyl-L-homocysteine + nocamycin I | S-adenosyl-L-methionine:nocamycin E O-methyltransferase | None | ncmP (gene name) | |
| 2.1.1.352 | 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine | S-adenosyl-L-methionine:3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase | None | None | |
| 2.3.1.278 | mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase | False | 2 | 0 | 0 | 1 | a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose = a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA | mycolipenoyl-CoA:2-(long-chain-fatty acyl)-trehalose 3-mycolipenoyltransferase | None | papA3 (gene name) | |
| 2.3.1.279 | long-chain-acyl-CoA---trehalose acyltransferase | False | 2 | 0 | 0 | 1 | a long-chain-fatty acyl-CoA + alpha,alpha-trehalose = a 2-(long-chain-fatty acyl)-trehalose + CoA | long-chain-fatty acyl-CoA:alpha,alpha-trehalose 2-acyltransferase | None | papA3 (gene name) | |
| 2.3.1.280 | (aminoalkyl)phosphonate N-acetyltransferase | False | 2 | 13 | 0 | 2 | acetyl-CoA + (aminomethyl)phosphonate = CoA + (acetamidomethyl)phosphonate | acetyl-CoA:(aminomethyl)phosphonate N-acetyltransferase | None | phnO (gene name) | |
| 2.4.1.360 | 2-hydroxyflavanone C-glucosyltransferase | False | 7 | 0 | 0 | 5 | UDP-alpha-D-glucose + a 2'-hydroxy-beta-oxodihydrochalcone = UDP + a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone | UDP-alpha-D-glucose:2'-hydroxy-beta-oxodihydrochalcone C6/8-beta-D-glucosyltransferase | None | OsCGT | |
| 2.5.1.148 | lycopaoctaene synthase | False | 1 | 0 | 0 | 2 | 2 geranylgeranyl diphosphate + NADPH + H+ = lycopaoctaene + 2 diphosphate + NADP+ (overall reaction);;(1a) 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate;;(1b) prephytoene diphosphate + NADPH + H+ = lycopaoctaene + diphosphate + NADP+ | geranylgeranyl-diphosphate:geranylgeranyl diphosphate geranylgeranyltransferase | None | LOS (gene name) | |
| 2.5.1.149 | lycopene elongase/hydratase (flavuxanthin-forming) | False | 2 | 0 | 0 | 1 | (1) prenyl diphosphate + all-trans-lycopene + acceptor + H2O = nonaflavuxanthin + reduced electron acceptor + diphosphate;;(2) prenyl diphosphate + nonaflavuxanthin + acceptor + H2O = flavuxanthin + reduced electron acceptor + diphosphate | prenyl-diphosphate:all-trans-lycopene prenyltransferase (hydrating, flavuxanthin-forming) | None | crtEb (gene name); dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, flavuxanthin-forming) | |
| 2.5.1.150 | lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming) | False | 4 | 1 | 0 | 3 | (1) prenyl diphosphate + all-trans-lycopene + H2O = dihydroisopentenyldehydrorhodopin + diphosphate;;(2) prenyl diphosphate + isopentenyldehydrorhodopin + H2O = dihydrobisanhydrobacterioruberin + diphosphate | prenyl-diphosphate:all-trans-lycopene prenyltransferase (hydrating, dihydrobisanhydrobacterioruberin-forming) | None | lbtA (gene name); lyeJ (gene name); dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, dihydrobisanhydrobacterioruberin-forming) | |
| 2.5.1.151 | alkylcobalamin dealkylase | False | 5 | 808 | 1 | 2 | (1) methylcob(III)alamin + [alkylcobalamin dealkylase] + glutathione = cob(I)alamin-[alkylcobalamin dealkylase] + an S-methyl glutathione;;(2) adenosylcob(III)alamin + [alkylcobalamin dealkylase] + glutathione = cob(I)alamin-[alkylcobalamin dealkylase] + S-adenosyl glutathione | methylcobalamin:glutathione S-methyltransferase | None | MMACHC (gene name); alkylcobalamin:glutathione S-alkyltransferase; alkylcobalamin reductase | |
| 4.2.3.198 | alpha-selinene synthase | False | 8 | 0 | 0 | 2 | (2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-selinene-forming) | None | LfTPS2 (gene name) | |
| 4.2.3.199 | (-)-5-epieremophilene synthase | False | 3 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate = (-)-5-epieremophilene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (-)-epieremophilene-forming] | None | STPS1 (gene name); STP2 (gene name); STP3 (gene name) | |
| 4.2.3.200 | beta-pinacene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = beta-pinacene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, beta-pinacene-forming) | None | PcS | |
| 4.6.1.18 | pancreatic ribonuclease | False | 112 | 115 | 43 | 32 | (1) an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA] (overall reaction);;(1a) an [RNA] containing cytidine = an [RNA]-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA];;(1b) an [RNA]-3'-cytidine-2',3'-cyclophosphate + H2O = an [RNA]-3'-cytidine-3'-phosphate;;(2) an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA];;(2a) an [RNA] containing uridine = an [RNA]-3'-uridine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA];;(2b) an [RNA]-3'-uridine-2',3'-cyclophosphate + H2O = an [RNA]-3'-uridine-3'-phosphate | RNA lyase ([RNA]-3'-cytidine/uridine-3'-phosphate and 5'-hydroxy-ribonucleotide-3'-[RNA] producing) | None | RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase | |
| 4.6.1.19 | ribonuclease T2 | False | 46 | 2968 | 1 | 48 | RNA + H2O = an [RNA fragment]-3'-nucleoside-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment] (overall reaction);;(1a) RNA = an [RNA fragment]-3'-nucleoside-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment];;(1b) an [RNA fragment]-3'-nucleoside-2',3'-cyclophosphate + H2O = an [RNA fragment]-3'-nucleoside-3'-phosphate | [RNA] 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- nucleoside-2',3'-cyclophosphate-forming and hydrolysing) | None | ribonuclease II; base-non-specific ribonuclease; nonbase-specific RNase; RNase (non-base specific); non-base specific ribonuclease; nonspecific RNase; RNase Ms; RNase M; RNase II; Escherichia coli ribonuclease II; ribonucleate nucleotido-2'-transferase (cyclizing); acid ribonuclease; RNAase CL; Escherichia coli ribonuclease I' ribonuclease PP2; ribonuclease N2; ribonuclease M; acid RNase; ribonnuclease (non-base specific); ribonuclease (non-base specific); RNase T2; ribonuclease PP3; ribonucleate 3'-oligonucleotide hydrolase; ribonuclease U4 | |
| 4.6.1.20 | ribonuclease U2 | False | 1 | 0 | 0 | 4 | (1) [RNA] containing adenosine + H2O = an [RNA fragment]-3'-adenosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment] (overall reaction);;(1a) [RNA] containing adenosine = an [RNA fragment]-3'-adenosine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment];;(1b) an [RNA fragment]-3'-adenosine-2',3'-cyclophosphate + H2O = an [RNA fragment]-3'-adenosine -3'-phosphate;;(2) [RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment] (overall reaction);;(2a) [RNA] containing guanosine = an [RNA fragment]-3'-guanosine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment];;(2b) an [RNA fragment]-3'-guanosine-2',3'-cyclophosphate + H2O = an [RNA fragment]-3'- guanosine-3'-phosphate | [RNA]-purine 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'-purine-nucleoside -2',3'-cyclophosphate-forming and hydrolysing) | None | purine specific endoribonuclease; ribonuclease U3; RNase U3; RNase U2; purine-specific ribonuclease; purine-specific RNase; Pleospora RNase; Trichoderma koningi RNase III; ribonuclease (purine) | |
| 4.6.1.21 | Enterobacter ribonuclease | False | 1 | 331 | 0 | 2 | RNA containing adenosine-cytidine + H2O = an [RNA fragment]-3'-cytidine-3'-phosphate + a 5'-a hydroxy-adenosine -3'-[RNA fragment] (overall reaction);;(1a) RNA containing adenosine-cytidine = an [RNA fragment]-3'-cytidine-2',3'-cyclophosphate + a 5'-a hydroxy-adenosine -3'-[RNA fragment];;(1b) an [RNA fragment]-3'-cytidine-2',3'-cyclophosphate + H2O = an [RNA fragment]-3'-cytidine-3'-phosphate | [RNA]-adenosine-cytidine 5'-hydroxy-adenosoine ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'-cytidine-2',3'-cyclophosphate-forming and hydrolysing) | None | None | |
| 4.6.1.22 | Bacillus subtilis ribonuclease | False | 2 | 11 | 0 | 4 | RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates | [RNA] 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- nucleoside -2',3'-cyclophosphate-forming) | None | Proteus mirabilis RNase; ribonucleate nucleotido-2'-transferase (cyclizing); bacterial RNA lyase; Bacillus subtilis intracellular ribonuclease | |
| 5.1.1.23 | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase | False | 3 | 1560 | 0 | 1 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + H2O = AMP + diphosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate L-glutamate-epimerase | None | murL (gene name); UDP-MurNAc-L-Ala-L-Glu epimerase | |
| 5.6.1.2 | dynein ATPase | False | 0 | 4 | 0 | 43 | ATP + H2O + a dynein associated with a microtubule at position n = ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | ATP phosphohydrolase (tubulin-translocating) | None | dynein adenosine 5'-triphosphatase | |
| 5.6.1.3 | plus-end-directed kinesin ATPase | False | 3 | 68 | 0 | 32 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | kinesin ATP phosphohydrolase (plus-end-directed) | None | kinesin | |
| 5.6.1.4 | minus-end-directed kinesin ATPase | False | 2 | 53 | 0 | 24 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | kinesin ATP phosphohydrolase (minus-end-directed) | None | non-claret disjunctional; ncd (gene name) | |
| 5.6.1.5 | proteasome ATPase | False | 0 | 76 | 0 | 35 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | ATP phosphohydrolase (polypeptide-degrading) | None | None | |
| 5.6.1.6 | channel-conductance-controlling ATPase | False | 42 | 2033 | 16 | 13 | ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel | ATP phosphohydrolase (channel-conductance-controlling) | None | cystic fibrosis transmembrane conductance regulator; CFTR (gene name) | |
| 5.6.1.7 | chaperonin ATPase | False | 1060 | 47077 | 49 | 48 | ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide | ATP phosphohydrolase (polypeptide-unfolding) | None | chaperonin | |
| 5.6.1.8 | myosin ATPase | False | 0 | 50 | 1 | 23 | ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1 | ATP phosphohydrolase (actin-translocating) | None | None | |
| 5.6.2.1 | DNA topoisomerase | False | 142 | 93107 | 4 | 70 | ATP-independent breakage of single-stranded DNA, followed by passage and rejoining | DNA topoisomerase | None | type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; omega-protein; deoxyribonucleate topoisomerase; topoisomerase | |
| 5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) | False | 373 | 193159 | 73 | 94 | ATP-dependent breakage, passage and rejoining of double-stranded DNA | DNA topoisomerase (ATP-hydrolysing) | None | type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II | |
| 6.3.2.53 | UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase | False | 10 | 658 | 0 | 2 | ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate | UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase (ADP-forming) | None | murD2 (gene name); UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate synthetase; UDP-MurNAc-L-Ala-L-Glu synthetase | |
| 7.2.2.19 | H+/K+-exchanging ATPase | False | 13 | 74 | 9 | 22 | ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | ATP phosphohydrolase (P-type,H+/K+-exchanging) | None | H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase | |
| 7.2.4.4 | biotin-dependent malonate decarboxylase | True | 0 | 0 | 0 | 2 | malonate + H+ + Na+[side 1] = acetate + CO2 + Na+[side 2] | malonate carboxy-lyase (biotin-dependent) | None | malonate decarboxylase (with biotin); malonate decarboxylase (ambiguous) | |
| 7.6.2.12 | ABC-type capsular-polysaccharide transporter | False | 2 | 0 | 0 | 7 | ATP + H2O + capsular polysaccharide-[capsular polysaccharide-binding protein][side 1] = ADP + phosphate + capsular polysaccharide[side 2] + [capsular polysaccharide-binding protein][side 1] | ATP phosphohydrolase (ABC-type, capsular-polysaccharide-exporting) | None | capsular-polysaccharide-transporting ATPase | |
| 1.13.11.88 | isoeugenol monooxygenase | False | 2 | 0 | 0 | 4 | isoeugenol + O2 = vanillin + acetaldehyde | isoeugenol:oxygen 7,8-oxidoreductase (bond-cleaving) | None | iem (gene name) | |
| 1.14.11.61 | feruloyl-CoA 6-hydroxylase | False | 11 | 647 | 0 | 5 | trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2 | feruloyl-CoA,2-oxoglutarate:oxygen oxidoreductase (6-hydroxylating) | None | None | |
| 1.14.11.62 | trans-4-coumaroyl-CoA 2-hydroxylase | False | 6 | 0 | 0 | 1 | trans-4-coumaroyl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + CO2 | (2E)-3-(4-hydroxyphenyl)prop-2-enoyl-CoA,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) | None | Diox4 (gene name); C2'H (gene name) | |
| 1.14.11.63 | peptidyl-lysine (3S)-dioxygenase | False | 2 | 3 | 0 | 3 | a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2 | [protein]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating) | None | JMJD7 (gene name); Jumonji domain-containing protein 7; JmjC domain-containing protein 7 | |
| 1.14.13.243 | toluene 2-monooxygenase | True | 0 | 0 | 0 | 2 | (1) toluene + NADH + H+ + O2 = 2-methylphenol + NAD+ + H2O;;(2) 2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O | toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating) | None | tomA1/2/3/4/5 (gene names); toluene ortho-monooxygenase | |
| 1.14.13.244 | phenol 2-monooxygenase (NADH) | False | 6 | 4 | 0 | 5 | phenol + NADH + H+ + O2 = catechol + NAD+ + H2O | phenol,NADH:oxygen oxidoreductase (2-hydroxylating) | None | dmpLMNOP (gene names) | |
| 1.14.13.245 | assimilatory dimethylsulfide S-monooxygenase | True | 0 | 0 | 0 | 1 | (1) dimethyl sulfide + NADH + H+ + O2 = dimethyl sulfoxide + NAD+ + H2O;;(2) dimethyl sulfoxide + NADH + H+ + O2 = dimethyl sulfone + NAD+ + H2O | dimethyl sulfide,NADH:oxygen oxidoreductase (S-oxidizing) | None | dsoBCDEF (gene names) | |
| 1.14.15.36 | sterol 14alpha-demethylase (ferredoxin) | False | 4 | 0 | 0 | 5 | a 14alpha-methylsteroid + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = a Delta14-steroid + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O (overall reaction);;(1a) a 14alpha-methylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a 14alpha-hydroxymethylsteroid + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;;(1b) a 14alpha-hydroxymethylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a 14alpha-formylsteroid + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(1c) a 14alpha-formylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a Delta14-steroid + formate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O;; | sterol,reduced ferredoxin:oxygen oxidoreductase (14-methyl cleaving) | None | cyp51 (gene name) | |
| 1.14.15.37 | luteothin monooxygenase | True | 0 | 0 | 0 | 2 | luteothin + 2 O2 + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ = aureothin + 3 H2O + 4 oxidized ferredoxin [iron-sulfur] cluster (overall reaction);;(1a) luteothin + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = (7R)-7-hydroxyluteothin + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster;;(1b) (7R)-7-hydroxyluteothin + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = aureothin + 2 H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | luteothin,ferredoxin:oxygen oxidoreductase (aureothin-forming) | None | aurH (gene name) | |
| 1.14.99.65 | 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase | False | 1 | 3 | 0 | 2 | 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + reduced acceptor + O2 = 2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + acceptor + H2O | 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein],acceptor:oxygen 3-oxidoreductase | None | cmlA (gene name) | |
| 2.1.1.353 | demethylluteothin O-methyltransferase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + demethylluteothin = S-adenosyl-L-homocysteine + luteothin | S-adenosyl-L-methionine:demethylluteothin O-methyltransferase | None | aurI (gene name) | |
| 2.3.1.281 | 5-hydroxydodecatetraenal polyketide synthase | True | 0 | 0 | 0 | 1 | 6 malonyl-CoA + 5 NADPH + NADH + 6 H+ = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O | malonyl-CoA:malonyl-CoA malonyltransferase ((2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal-forming) | None | cpkABC (gene names) | |
| 2.3.1.282 | phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase | False | 11 | 1551 | 0 | 2 | (1) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol = a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase];;(2) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase];;(3) 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase];; | mycocerosyl-[mycocerosic acid synthase]:phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase | None | papA5 (gene name) | |
| 2.3.1.283 | 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase | False | 5 | 0 | 0 | 1 | a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose = a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase] | (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2'-acyl-2-O-sulfo-alpha,alpha-trehalose 3'-(hydroxy)phthioceranyltransferase | None | papA1 (gene name) | |
| 2.3.1.284 | 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase | False | 1 | 0 | 0 | 1 | 3 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose = 3,6,6'-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2'-sulfo-alpha-alpha-trehalose + 2 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose | 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose:3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose 6,6'-di(hydroxy)phthioceranyltransferase | None | chp1 (gene name) | |
| 2.3.1.285 | (13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase | False | 1 | 0 | 0 | 1 | acetyl-CoA + (13S,14R)-1,13-dihydroxy-cis-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + CoA | acetyl-CoA:(13S,14R)-1,13-dihydroxy-cis-N-methylcanadine O-acetyltransferase | None | AT1 (gene name) | |
| 2.4.1.361 | GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase | False | 2 | 0 | 0 | 1 | 2 GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = 2 GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate (overall reaction);;(1a) GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate;;(1b) GDP-alpha-D-mannose + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate | GDP-alpha-D-mannose:bis(myo-inositol)-1,3'-phosphate 2-beta-D-mannosyltransferase | None | MDIP synthase | |
| 2.4.1.362 | alpha-(1->3) branching sucrase | True | 0 | 0 | 0 | 2 | sucrose + a (1->6)-alpha-D-glucan = D-fructose + a (1->6)-alpha-D-glucan containing a (1->3)-alpha-D-glucose branch | sucrose:(1->6)-alpha-D-glucan 3-alpha-D-[(1->3)-alpha-D-glucosyl]-transferase | None | branching sucrase A; BRS-A; brsA (gene name) | |
| 2.5.1.152 | D-histidine 2-aminobutanoyltransferase | False | 1 | 1 | 2 | 1 | S-adenosyl-L-methionine + D-histidine = N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine | S-adenosyl-L-methionine:D-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase | None | cntL (gene name) | |
| 2.6.1.115 | 5-hydroxydodecatetraenal 1-aminotransferase | True | 0 | 0 | 0 | 1 | (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine | (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol:pyruvate aminotransferase | None | cpkG (gene name) | |
| 2.7.1.225 | L-serine kinase (ATP) | False | 1 | 3 | 0 | 1 | ATP + L-serine = ADP + O-phospho-L-serine | ATP:L-serine 3-phosphotransferase | None | sbnI (gene name) | |
| 2.7.1.226 | L-serine kinase (ADP) | False | 1 | 1 | 0 | 1 | ADP + L-serine = AMP + O-phospho-L-serine | ADP:L-serine 3-phosphotransferase | None | serK (gene name) | |
| 3.1.1.105 | 3-O-acetylpapaveroxine carboxylesterase | False | 2 | 0 | 0 | 1 | 3-O-acetylpapaveroxine + H2O = narcotine hemiacetal + acetate | 3-O-acetylpapaveroxine acetatehydrolase | None | CXE1 (gene name) | |
| 3.1.4.59 | cyclic-di-AMP phosphodiesterase | False | 5 | 32 | 0 | 11 | cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine | cyclic bis(3'->5')diadenylate 3'-adenylylhydrolase | None | gdpP (gene name) | |
| 3.1.4.60 | pApA phosphodiesterase | True | 0 | 0 | 0 | 4 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP | 5'-O-phosphonoadenylyl-(3'->5')-adenosine phosphohydrolase | None | pde2 (gene name); pApA hydrolase | |
| 3.5.1.131 | 1-carboxybiuret hydrolase | False | 1 | 26 | 0 | 1 | 1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3 | 1-carboxybiuret amidohydrolase | None | atzEG (gene names) | |
| 3.5.1.132 | [amino group carrier protein]-ornithine hydrolase | False | 15 | 935 | 0 | 0 | [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine | [amino group carrier protein]-C-terminal-gamma-L-ornithyl-L-glutamate amidohydrolase | None | lysK (gene name) | |
| 4.1.1.116 | D-ornithine/D-lysine decarboxylase | False | 1 | 4 | 5 | 1 | (1) D-ornithine = putrescine + CO2;;(2) D-lysine = cadaverine + CO2 | D-ornithine/D-lysine carboxy-lyase | None | dokD (gene name); DOKDC | |
| 4.1.1.117 | 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase | False | 1 | 3 | 0 | 1 | 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 | 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming) | None | sbnH (gene name) | |
| 4.2.99.24 | thebaine synthase | False | 2 | 0 | 2 | 1 | salutaridinol 7-O-acetate = thebaine + acetate | salutaridinol 7-O-acetate acetate-lyase (thebaine-forming) | None | THS | |
| 5.1.1.24 | histidine racemase | False | 1 | 2 | 0 | 1 | L-histidine = D-histidine | histidine racemase | None | cntK (gene name) | |
| 5.1.3.43 | sulfoquinovose mutarotase | True | 0 | 0 | 0 | 1 | 6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose | 6-sulfo-D-quinovose 1-epimerase | None | None | |
| 6.2.1.56 | 4-hydroxybutyrate---CoA ligase (ADP-forming) | False | 1 | 0 | 1 | 1 | ATP + 4-hydroxybutanoate + CoA = ADP + phosphate + 4-hydroxybutanoyl-CoA | 4-hydroxybutanoate:CoA ligase (ADP-forming) | None | Nmar_0206 (locus name) | |
| 6.3.2.54 | L-2,3-diaminopropanoate---citrate ligase | False | 1 | 1 | 0 | 1 | ATP + L-2,3-diaminopropanoate + citrate = AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate | L-2,3-diaminopropanoate:citrate ligase (2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate-forming) | None | sbnE (gene name); 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate synthtase | |
| 6.3.2.55 | 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase | False | 1 | 1 | 0 | 1 | ATP + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + L-2,3-diaminopropanoate = AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate | 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate:L-2,3-diaminopropanoate ligase {2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate-forming} | None | sbnF (gene name) | |
| 6.3.2.56 | staphyloferrin B synthase | False | 1 | 1 | 0 | 1 | ATP + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate = AMP + diphosphate + staphyloferrin B | 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate:2-oxoglutarate ligase (staphyloferrin B-forming) | None | sbnC (gene name) | |
| 6.3.5.13 | lipid II isoglutaminyl synthase (glutamine-hydrolysing) | False | 6 | 15577 | 1 | 2 | ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + L-glutamine + H2O = ADP + phosphate + beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol + L-glutamate (overall reaction);;(1a) L-glutamine + H2O = L-glutamate + NH3;;(1b) ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol = ADP + beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol;;(1c) beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + NH3 = beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol + phosphate | beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol:L-glutamine amidoligase (ADP-forming) | None | MurT/GatD; MurT/GatD complex | |
| 7.2.4.5 | glutaconyl-CoA decarboxylase | False | 4 | 0 | 0 | 6 | (2E)-4-carboxybut-2-enoyl-CoA + Na+[side 1] = (2E)-but-2-enoyl-CoA + CO2 + Na+[side 2] | (2E)-4-carboxybut-2-enoyl-CoA carboxy-lyase [(2E)-but-2-enoyl-CoA-forming] | None | glutaconyl coenzyme A decarboxylase; pent-2-enoyl-CoA carboxy-lyase; 4-carboxybut-2-enoyl-CoA carboxy-lyase | |
| 1.1.1.417 | 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating) | False | 1 | 1 | 0 | 1 | a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(P)+ = a 4alpha-methyl-3-oxosteroid + NAD(P)H + CO2 + H+ | 3beta-hydroxysteroid-4beta-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating) | None | sdmB (gene name) | |
| 1.1.1.418 | plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) | False | 2 | 0 | 0 | 2 | a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH | 3beta-hydroxysteroid-4alpha-carboxylate:NAD+ 3-oxidoreductase (decarboxylating) | None | 3beta-HSD/D1 (gene name); 3beta-HSD/D2 (gene name); 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylase (ambiguous) | |
| 1.14.13.246 | 4beta-methylsterol monooxygenase | False | 1 | 2 | 0 | 1 | a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O (overall reaction);;(1a) a 3beta-hydroxy-4,4-dimethylsteroid + NADH + H+ + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NAD+ + H2O;;(1b) a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NADH + H+ + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NAD+ + 2 H2O;;(1c) a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + H+ + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD+ + H2O | 3beta-hydroxy-4,4-dimethylsteroid,NADH:oxygen oxidoreductase (C-4mbeta-hydroxylating) | None | sdmA (gene name) | |
| 1.14.14.171 | beta-amyrin 16alpha-hydroxylase | False | 1 | 0 | 0 | 2 | beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 16alpha-hydroxy-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + H2O | beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (16alpha-hydroxylating) | None | CYP87D16 | |
| 1.14.18.10 | plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase | False | 2 | 0 | 0 | 7 | 24-methylidenecycloartanol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O (overall reaction);;(1a) 24-methylidenecycloartanol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-(hydroxymethyl)-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferricytochrome b5 + H2O;;(1b) 4alpha-(hydroxymethyl)-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferricytochrome b5 + 2 H2O;;(1c) 4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-4alpha-carboxylate + 2 ferricytochrome b5 + H2O | 24-methylidenecycloartanol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating) | None | SMO1 (gene name) | |
| 1.14.18.11 | plant 4alpha-monomethylsterol monooxygenase | False | 3 | 0 | 0 | 6 | 24-methylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O (overall reaction);;(1a) 24-methylidenelophenol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-(hydroxymethyl)ergosta-7,24(241)-dien-3beta-ol + 2 ferricytochrome b5 + H2O;;(1b) 4alpha-(hydroxymethyl)ergosta-7,24(241)-dien-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-formylergosta-7,24(241)-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O;;(1c) 4alpha-formylergosta-7,24(241)-dien-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + 2 ferricytochrome b5 + H2O | 24-ethylidenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating) | None | SMO2 (gene name) | |
| 2.3.1.286 | protein acetyllysine N-acetyltransferase | False | 186 | 39864 | 39 | 13 | [protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide (overall reaction);;(1a) [protein]-N6-acetyl-L-lysine + NAD+ = [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide;;(1b) [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose | [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming) | None | Sir2; protein lysine deacetylase; NAD+-dependent protein deacetylase | |
| 2.3.1.287 | phthioceranic/hydroxyphthioceranic acid synthase | False | 5 | 0 | 0 | 1 | (1) 8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH + 16 H+ = 8 CoA + C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP+ + 8 CO2 + 8 H2O;;(2) 7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH + 14 H+ = 7 CO2 + C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP+ + 7 CoA + 7 H2O | (S)-methylmalonyl-CoA:palmitoyl-[(hydroxy)phthioceranic acid synthase] methylmalonyltransferase (phthioceranyl-[(hydroxy)phthioceranic acid synthase]-forming) | None | msl2 (gene name); PKS2 | |
| 2.4.1.363 | ginsenoside 20-O-glucosyltransferase | False | 3 | 0 | 0 | 1 | UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + ginsenoside C-K | UDP-alpha-D-glucose:(20S)-protopanaxadiol 20-O-glucosyltransferase (configuration-inverting) | None | UGT71A27 (gene name) | |
| 2.4.1.364 | protopanaxadiol-type ginsenoside 3-O-glucosyltransferase | False | 1 | 0 | 0 | 2 | (1) UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + (20S)-ginsenoside Rh2;;(2) UDP-alpha-D-glucose + ginsenoside C-K = UDP + ginsenoside F2 | UDP-alpha-D-glucose:protopanaxadiol-type ginsenoside 3-O-glucosyltransferase (configuration-retaining) | None | UGT74AE2 (gene name) | |
| 2.4.1.365 | protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase | False | 1 | 0 | 0 | 1 | (1) UDP-alpha-D-glucose + (20S)-ginsenoside Rh2 = UDP + (20S)-ginsenoside Rg3;;(2) UDP-alpha-D-glucose + ginsenoside F2 = UDP + ginsenoside Rd | UDP-alpha-D-glucose:3-O-glucosyl-protopanaxadiol-type ginsenoside 2''-O-glucosyltransferase | None | UGT94Q2 (gene name) | |
| 2.4.1.366 | ginsenoside F1 6-O-glucosyltransferase | False | 2 | 0 | 0 | 1 | UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 | UDP-alpha-D-glucose:ginsenoside F1 6-O-glucosyltransferase | None | UGTPg101 (gene name) | |
| 2.4.1.367 | ginsenoside 6-O-glucosyltransferase | False | 1 | 0 | 0 | 1 | (1) UDP-alpha-D-glucose + protopanaxatriol = UDP + ginsenoside Rh1;;(2) UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 | UDP-alpha-D-glucose:ginsenoside 6-O-glucosyltransferase | None | UGTPg100 (gene name) | |
| 2.4.1.368 | oleanolate 3-O-glucosyltransferase | False | 5 | 0 | 0 | 1 | UDP-alpha-D-glucose + oleanolate = UDP + oleanolate 3-O-beta-D-glucoside | UDP-alpha-D-glucose:oleanolate 3-O-glucosyltransferase | None | UGT73C10 (gene name); UGT73C11 (gene name) | |
| 3.1.1.106 | O-acetyl-ADP-ribose deacetylase | False | 25 | 911 | 1 | 7 | (1) 3''-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate;;(2) 2''-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate | O-acetyl-ADP-D-ribose carboxylesterase | None | ymdB (gene name); MACROD1 (gene name) | |
| 3.7.1.24 | 2,4-diacetylphloroglucinol hydrolase | False | 4 | 0 | 0 | 4 | 2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate | 2,4-diacetylphloroglucinol acetylhydrolase | None | PhlG | |
| 3.7.1.25 | 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase | False | 1 | 21 | 0 | 4 | (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate | (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase | None | todF (gene name) | |
| 4.2.3.201 | hydropyrene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = hydropyrene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrene-forming) | None | HpS | |
| 4.2.3.202 | hydropyrenol synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate + H2O = hydropyrenol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrenol-forming) | None | HpS | |
| 4.2.3.203 | isoelisabethatriene synthase | False | 1 | 0 | 0 | 1 | geranylgeranyl diphosphate = isoelisabethatriene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, isoelisabethatriene-forming) | None | HpS (ambiguous) | |
| 6.2.1.57 | long-chain fatty acid adenylase/transferase FadD23 | False | 3 | 0 | 3 | 2 | (1) ATP + stearate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a stearoyl-[(hydroxy)phthioceranic acid synthase] (overall reaction);;(1a) ATP + stearate = diphosphate + (stearoyl)adenylate;;(1b) (stearoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a stearoyl-[(hydroxy)phthioceranic acid synthase];;(2) ATP + palmitate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a palmitoyl-[(hydroxy)phthioceranic acid synthase] (overall reaction);;(2a) ATP + palmitate = diphosphate + (palmitoyl)adenylate;;(2b) (palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a palmitoyl-[(hydroxy)phthioceranic acid synthase];; | palmitate:holo-[(hydroxy)phthioceranic acid synthase] ligase | None | fadD23 (gene name); long-chain fatty acid adenylyltransferase FadD23 | |
| 6.3.2.57 | staphyloferrin A synthase | False | 1 | 0 | 0 | 1 | ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A | N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming) | None | sfnaB (gene name) | |
| 7.3.2.7 | arsenite-transporting ATPase | False | 11 | 1245 | 0 | 14 | ATP + H2O + arsenite[side 1] = ADP + phosphate + arsenite[side 2] | ATP phosphohydrolase (arsenite-exporting) | None | arsAB (gene names) | |
| 7.4.2.10 | ABC-type glutathione transporter | False | 16 | 8160 | 0 | 6 | ATP + H2O + glutathione-[glutathione-binding protein][side 1] = ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1] | ATP phosphohydrolase (ABC-type,glutathione-importing) | None | glutathione transporting ATPase; glutathione ABC transporter; gsiACD (gene names) | |
| 7.4.2.11 | ABC-type methionine transporter | False | 260 | 0 | 0 | 1 | (1) ATP + H2O + L-methionine-[methionine-binding protein][side 1] = ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1] ;;(2) ATP + H2O + D-methionine-[methionine-binding protein][side 1] = ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, methionine-importing) | None | methionine transporting ATPase; methionine ABC transporter; metNIQ (gene names) | |
| 7.4.2.12 | ABC-type cystine transporter | False | 1 | 0 | 0 | 5 | (1) ATP + H2O + L-cystine-[cystine-binding protein][side 1] = ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1] ;;(2) ATP + H2O + D-cystine-[cystine-binding protein][side 1] = ADP + phosphate + D-cystine[side 2] + [cystine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, cystine-importing) | None | cystine transporting ATPase; cystine ABC transporter | |
| 7.5.2.7 | ABC-type D-ribose transporter | False | 130 | 0 | 0 | 4 | ATP + H2O + D-ribose-[ribose-binding protein][side 1] = ADP + phosphate + D-ribose[side 2] + [ribose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-ribose-importing) | None | D-ribose transporting ATPase; D-ribose ABC transporter; rbsACB (gene names) | |
| 7.5.2.8 | ABC-type D-allose transporter | False | 1 | 0 | 0 | 1 | ATP + H2O + D-allose-[allose-binding protein][side 1] = ADP + phosphate + D-allose[side 2] + [allose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-allose-importing) | None | D-allose transporting ATPase; D-allose ABC transporter; alsBAC (gene names) | |
| 7.5.2.9 | ABC-type D-galactofuranose transporter | False | 2 | 0 | 0 | 1 | ATP + H2O + D-galactofuranose-[galactofuranose-binding protein][side 1] = ADP + phosphate + D-galactofuranose[side 2] + [galactofuranose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-galactofuranose-transporting) | None | D-galactofuranose transporting ATPase; D-galactofuranose ABC transporter | |
| 7.5.2.10 | ABC-type D-xylose transporter | False | 33 | 0 | 0 | 3 | ATP + H2O + D-xylose-[xylose-binding protein][side 1] = ADP + phosphate + D-xylose[side 2] + [xylose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-xylose-transporting) | None | D-xylose transporting ATPase; D-xylose ABC transporter; xylFGH (gene names) | |
| 7.5.2.11 | ABC-type D-galactose transporter | False | 61 | 4524 | 0 | 5 | ATP + H2O + D-galactose-[galactose-binding protein][side 1] = ADP + phosphate + D-galactose[side 2] + [galactose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-galactose-importing) | None | D-galactose transporting ATPase; D-galactose ABC transporter; mglBAC (gene names) | |
| 7.5.2.12 | ABC-type L-arabinose transporter | False | 42 | 0 | 0 | 3 | ATP + H2O + L-arabinose-[arabinose-binding protein][side 1] = ADP + phosphate + L-arabinose[side 2] + [arabinose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, L-arabinose-importing) | None | L-arabinose transporting ATPase; L-arabinose ABC transporter; araFGH (gene names) | |
| 7.5.2.13 | ABC-type D-xylose/L-arabinose transporter | False | 3 | 0 | 0 | 2 | (1) ATP + H2O + D-xylose-[xylose-binding protein][side 1] = ADP + phosphate + D-xylose[side 2] + [xylose-binding protein][side 1] ;; (2) ATP + H2O + L-arabinose-[arabinose-binding protein][side 1] = ADP + phosphate + L-arabinose[side 2] + [arabinose-binding protein][side 1] | ATP phosphohydrolase (ABC-type, D-xylose/L-arabinose-importing) | None | None | |
| 7.6.2.13 | ABC-type autoinducer-2 transporter | False | 28 | 1698 | 0 | 2 | ATP + H2O + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran-[AI-2-binding protein][side 1] = ADP + phosphate + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran[side 2] + [AI-2-binding protein][side 1] | ATP phosphohydrolase (ABC-type, AI-2 importing) | None | autoinducer-2 transporting ATPase; autoinducer-2 ABC transporter; LsrACDB (gene names) | |
| 1.3.1.120 | cyclohexane-1-carbonyl-CoA reductase (NADP+) | False | 1 | 0 | 0 | 1 | cyclohexane-1-carbonyl-CoA + NADP+ = cyclohex-1-ene-1-carbonyl-CoA + NADPH + H+ | cyclohexane-1-carbonyl-CoA:NADP+ 1-oxidoreductase | None | 1-cyclohexenylcarbonyl-CoA reductase (ambiguous); chcA (gene name) | |
| 1.3.98.5 | hydrogen peroxide-dependent heme synthase | False | 58 | 4214 | 0 | 8 | Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O (overall reaction);;(1a) Fe-coproporphyrin III + H2O2 = harderoheme III + CO2 + 2 H2O;;(1b) harderoheme III + H2O2 = protoheme + CO2 + 2 H2O | Fe-coproporphyrin III:hydrogen peroxide oxidoreductase (decarboxylating) | None | coproheme III oxidative decarboxylase; hemQ (gene name) | |
| 1.3.98.6 | AdoMet-dependent heme synthase | False | 3 | 4 | 0 | 2 | Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine | Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating) | None | ahbD (gene name); SAM-dependent heme synthase | |
| 1.8.1.21 | dissimilatory dimethyldisulfide reductase | True | 0 | 0 | 0 | 1 | 2 methanethiol + NAD+ = dimethyl disulfide + NADH + H+ | methanethiol:NAD+ oxidoreductase (dimethyl disulfide-forming) | None | None | |
| 1.13.11.89 | (hydroxymethyl)phosphonate dioxygenase | False | 1 | 0 | 0 | 1 | (hydroxymethyl)phosphonate + O2 = formate + phosphate | (hydroxymethyl)phosphonate:oxygen 1-oxidoreductase (formate-forming) | None | phnZ1 (gene name) | |
| 1.14.11.64 | glutarate dioxygenase | False | 35 | 959 | 3 | 2 | glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2 | glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming) | None | csiD (gene name) | |
| 1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase | False | 18 | 4150 | 0 | 8 | a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6-dimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase | None | KDM3A (gene name); KDM3B (gene name); JMJD1A (gene name); JMJD1B (gene name); JHDM2A (gene name); JHDM2B (gene name); KDM7B (gene name); PHF8 (gene name); HR (gene name) | |
| 1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase | False | 16 | 4630 | 5 | 6 | a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6,N6-trimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase | None | KDM4A (gene name); KDM4B (gene name); KDM4C (gene name); KDM4D (gene name); JHDM3A (gene name); JMJD2 (gene name); JMJD2A (gene name); GASC1 (gene name) | |
| 1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase | False | 22 | 5966 | 2 | 11 | a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2;;(1c) a [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine4 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6,N6-trimethyl-L-lysine4,2-oxoglutarate:oxygen oxidoreductase | None | KDM5A (gene name); KDM5B (gene name); KDM5C (gene name); KDM5D (gene name); JARID1A (gene name) | |
| 1.14.11.68 | [histone H3]-trimethyl-L-lysine27 demethylase | False | 10 | 4768 | 0 | 6 | a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase | None | KDM6A (gene name); KDM6C (gene name); UTX (gene name); UTY (gene name); JMJD3 (gene name) | |
| 1.14.11.69 | [histone H3]-trimethyl-L-lysine36 demethylase | False | 6 | 2 | 0 | 7 | a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction);;(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2;;(1b) a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | [histone H3]-N6,N6,N6-trimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase | None | KDM4A (gene name); KDM4B (gene name); RPH1 (gene name); JHDM3A (gene name); JHDM3B (gene name); JMJD2A (gene name); JMJD2B (gene name) | |
| 1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase | False | 6 | 1145 | 36 | 5 | a [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 acceptor + 2 H2O = a [histone H3]-L-lysine4 + 2 formaldehyde + 2 reduced acceptor (overall reaction);;(1a) a [histone H3]-N6,N6-dimethyl-L-lysine4 + acceptor + H2O = a [histone H3]-N6-methyl-L-lysine4 + formaldehyde + reduced acceptor;;(1b) a [histone H3]-N6-methyl-L-lysine4 + acceptor + H2O = a [histone H3]-L-lysine4 + formaldehyde + reduced acceptor | [histone H3]-N6,N6-dimethyl-L-lysine4:acceptor oxidoreductase (demethylating) | None | KDM1 (gene name); LSD1 (gene name); lysine-specific histone demethylase 1 | |
| 2.1.1.354 | [histone H3]-lysine4 N-trimethyltransferase | False | 51 | 6806 | 17 | 11 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4;;(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 | S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-trimethyltransferase | None | KMT2H (gene name); KMT3C (gene name); KMT3D (gene name); KMT3E (gene name); PRDM9 (gene name); MLL5 (gene name); ASH1L (gene name); SMYD1 (gene name); SMYD2 (gene name); SMYD3 (gene name) | |
| 2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase | False | 27 | 1704 | 3 | 10 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;;(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-trimethyltransferase | None | KMT1A (gene name); KMT1B (gene name); KMT1C (gene name); KMT1D (gene name); KMT1F (gene name); MT8 (gene name); SUV39H1 (gene name); G9A (gene name); EHMT1 (gene name); PRDM2 (gene name) | |
| 2.1.1.356 | [histone H3]-lysine27 N-trimethyltransferase | False | 21 | 4084 | 12 | 11 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27;;(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 | S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-trimethyltransferase | None | KMT6A (gene name); KMT6B (gene name); EZH1 (gene name); EZH2 (gene name) | |
| 2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase | False | 12 | 53 | 13 | 2 | 2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-dimethyltransferase | None | KMT3B (gene name); KMT3C (gene name); NSD2 (gene name); SETMAR (gene name); WHSC1 (gene name) | |
| 2.1.1.359 | [histone H3]-lysine36 N-trimethyltransferase | False | 30 | 2850 | 9 | 11 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36;;(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-trimethyltransferase | None | SET2 (gene name); KMT3A (gene name) | |
| 2.1.1.360 | [histone H3]-lysine79 N-trimethyltransferase | False | 22 | 4768 | 9 | 6 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79;;(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | S-adenosyl-L-methionine:[histone H3]-L-lysine79 N6-trimethyltransferase | None | DOT1L (gene name); KMT4 (gene name) | |
| 2.1.1.361 | [histone H4]-lysine20 N-methyltransferase | False | 29 | 3097 | 2 | 3 | S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase | None | KMT5A (gene name); SET8 (gene name); PR-SET7 (gene name) | |
| 2.1.1.362 | [histone H4]-N-methyl-L-lysine20 N-methyltransferase | False | 18 | 2014 | 3 | 3 | S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20 | S-adenosyl-L-methionine:[histone H4]-N6-methyl-L-lysine20 N6-methyltransferase | None | KMT5B (gene name); KMT5C (gene name); SUV420H1 (gene name); SUV420H2 (gene name) | |
| 2.3.1.288 | 2-O-sulfo trehalose long-chain-acyltransferase | False | 5 | 0 | 1 | 1 | (1) stearoyl-CoA + 2-O-sulfo-alpha,alpha-trehalose = 2-O-sulfo-2'-stearoyl-alpha,alpha-trehalose + CoA;;(2) palmitoyl-CoA + 2-O-sulfo-alpha,alpha-trehalose = 2-O-sulfo-2'-palmitoyl-alpha,alpha-trehalose + CoA;; | acyl-CoA:2-O-sulfo-alpha,alpha-trehalose 2'-long-chain-acyltransferase | None | papA2 (gene name) | |
| 2.3.1.289 | aureothin polyketide synthase system | True | 0 | 0 | 0 | 1 | 4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+ = demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O | malonyl-CoA/(S)-methylmalonyl-CoA:4-nitrobenzoyl-CoA (methyl)malonyltransferase (demethylluteothin-forming) | None | aurABC (gene names); aureothin polyketide synthase complex | |
| 2.3.1.290 | spectinabilin polyketide synthase system | True | 0 | 0 | 0 | 2 | 4-nitrobenzoyl-CoA + malonyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH + 4 H+ = demethyldeoxyspectinabilin + 7 CO2 + 8 CoA + 6 NADP+ + 5 H2O | malonyl-CoA/(S)-methylmalonyl-CoA:4-nitrobenzoyl-CoA (methyl)malonyltransferase (demethyldeoxyspectinabilin-forming) | None | norAA'BC (gene names); spectinabilin polyketide synthase complex | |
| 2.3.1.291 | sphingoid base N-palmitoyltransferase | False | 5 | 14 | 0 | 2 | palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA | palmitoyl-CoA:sphingoid base N-palmitoyltransferase | None | mammalian ceramide synthase 5; CERS5 (gene name); LASS5 (gene name) | |
| 2.4.1.369 | enterobactin C-glucosyltransferase | False | 1 | 0 | 0 | 1 | (1) UDP-alpha-D-glucose + enterobactin = UDP + monoglucosyl-enterobactin;;(2) UDP-alpha-D-glucose + monoglucosyl-enterobactin = UDP + diglucosyl-enterobactin;;(3) UDP-alpha-D-glucose + diglucosyl-enterobactin = UDP + triglucosyl-enterobactin | UDP-alpha-D-glucose:enterobactin 5'-C-beta-D-glucosyltransferase (configuration-inverting) | None | iroB (gene name) | |
| 2.4.1.370 | inositol phosphorylceramide mannosyltransferase | False | 2 | 13 | 0 | 1 | GDP-alpha-D-mannose + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine = a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + GDP | GDP-alpha-D-mannose:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine mannosyltransferase (configuration-retaining) | None | SUR1 (gene name); CSH1 (gene name) | |
| 3.1.1.107 | apo-salmochelin esterase | False | 1 | 0 | 0 | 1 | (1) enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer;;(2) triglucosyl-enterobactin + H2O = triglucosyl-(2,3-dihydroxybenzoylserine)3;;(3) diglucosyl-enterobactin + H2O = diglucosyl-(2,3-dihydroxybenzoylserine)3;;(4) monoglucosyl-enterobactin + H2O = monoglucosyl-(2,3-dihydroxybenzoylserine)3 | apo-salmochelin esterase | None | iroE (gene name) | |
| 3.1.1.108 | iron(III)-enterobactin esterase | False | 5 | 1 | 3 | 5 | iron(III)-enterobactin + 3 H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + 2 N-(2,3-dihydroxybenzoyl)-L-serine (overall reaction);;(1a) iron(III)-enterobactin + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;;(1b) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + N-(2,3-dihydroxybenzoyl)-L-serine;;(1c) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + N-(2,3-dihydroxybenzoyl)-L-serine | iron(III)-enterobactin hydrolase | None | fes (gene name); pfeE (gene name); enterochelin hydrolase; enterochelin esterase; ferric enterobactin esterase | |
| 3.1.1.109 | iron(III)-salmochelin esterase | False | 1 | 0 | 0 | 1 | (1) iron(III)-[diglucosyl-enterobactin] complex + H2O = iron(III)-[salmochelin S2] complex;;(2) iron(III)-[monoglucosyl-enterobactin] complex + H2O = iron(III)-[monoglucosyl-(2,3-dihydroxybenzoylserine)3] complex;;(3) iron(III)-[salmochelin S2] complex + H2O = iron(III)-[diglucosyl-(2,3-dihydroxybenzoylserine)2] complex + N-(2,3-dihydroxybenzoyl)-L-serine;;(4) iron(III)-[salmochelin S2] complex + H2O = iron(III)-[salmochelin S1] complex + salmochelin SX;;(5) iron(III)-[monoglucosyl-(2,3-dihydroxybenzoylserine)3] complex + H2O = iron(III)-[salmochelin S1] complex + N-(2,3-dihydroxybenzoyl)-L-serine;;(6) iron(III)-[diglucosyl-(2,3-dihydroxybenzoylserine)2] complex + H2O = iron(III)-[salmochelin SX] complex + salmochelin SX | iron(III)-salmochelin complex hydrolase | None | iroD (gene name); ferric-salmochelin esterase | |
| 3.1.3.106 | 2-lysophosphatidate phosphatase | False | 8 | 940 | 0 | 7 | a 1-acyl-sn-glycerol 3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate | 1-acyl-sn-glycerol 3-phosphate phosphohydrolase | None | 1-acyl-sn-glycerol 3-phosphatase; CPC3 (gene name); PHM8 (gene name) | |
| 3.2.1.209 | endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase | False | 2 | 0 | 0 | 10 | Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + D-mannopyranose | Man9GlcNAc2-[protein]2-alpha-mannohydrolase (configuration-inverting) | None | MAN1B1 (gene name); MNS1 (gene name); MNS3 (gene name) | |
| 3.5.1.133 | Nalpha-acyl-L-glutamine aminoacylase | False | 1 | 0 | 0 | 2 | an Nalpha-acyl-L-glutamine + H2O = L-glutamine + a carboxylate | Nalpha-acyl-L-glutamine amidohydrolase (carboxylate-forming) | None | agaA (gene name); axillary malodor releasing enzyme; AMRE | |
| 4.2.3.204 | valerianol synthase | False | 7 | 0 | 0 | 1 | (2E,6E)-farnesyl diphosphate + H2O = valerianol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valerianol-forming) | None | ChTPS1 (gene name); CsiTPS8 (gene name) | |
| 6.3.2.58 | D-ornithine---citrate ligase | False | 1 | 0 | 0 | 1 | ATP + D-ornithine + citrate = AMP + diphosphate + N5-[(S)-citryl]-D-ornithine | D-ornithine:citrate ligase {3-[(2-aminopentan-5-oylcarbamoyl)methyl]-3-hydroxybutanoate-forming} | None | sfnaD (gene name) | |
| 7.2.2.20 | ABC-type Zn2+ transporter | False | 94 | 0 | 0 | 8 | ATP + H2O + Zn2+-[zinc-binding protein][side 1] = ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1] | ATP phosphohydrolase (ABC-type, Zn2+-importing) | None | Zn2+-transporting ATPase; Zn2+ ABC transporter; znuABC (gene names) | |
| 7.6.2.14 | ABC-type aliphatic sulfonate transporter | False | 96 | 0 | 0 | 4 | ATP + H2O + aliphatic sulfonate-[sulfonate-binding protein][side 1] = ADP + phosphate + aliphatic sulfonate[side 2] + [sulfonate-binding protein][side 1] | ATP phosphohydrolase (ABC-type, aliphatic sulfonate-importing) | None | aliphatic sulfonate transporting ATPase; alkane sulfonate ABC transporter; aliphatic sulfonate ABC transporter; ssuACB (gene names) | |
| 7.6.2.15 | ABC-type thiamine transporter | False | 44 | 0 | 0 | 4 | ATP + H2O + thiamine-[thiamine-binding protein][side 1] = ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, thiamine-importing) | None | thiamin transporting ATPase; thiamine ABC transporter; thiamin ABC transporter; thiamine transporting ATPase; thiBPQ (gene names) | |
| 7.6.2.16 | ABC-type putrescine transporter | False | 4 | 0 | 0 | 3 | ATP + H2O + putrescine-[putrescine-binding protein][side 1] = ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, putrescine-importing) | None | putrescine transporting ATPase; putrescine ABC transporter; potFGHI (gene names) | |
| 1.1.1.419 | nepetalactol dehydrogenase | False | 1 | 0 | 0 | 1 | (1) (+)-cis,cis-nepetalactol + NAD+ = (+)-cis,cis-nepetalactone + NADH + H+;;(2) (+)-cis,trans-nepetalactol + NAD+ = (+)-cis,trans-nepetalactone + NADH + H+ | nepetalactol:NAD+ 1-oxidoreductase | None | NEPS1 (gene name) | |
| 1.1.5.13 | (S)-2-hydroxyglutarate dehydrogenase | False | 3 | 902 | 0 | 3 | (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol | (S)-2-hydroxyglutarate:quinone oxidoreductase | None | L-2-hydroxyglutarate dehydrogenase; lhgO (gene name); ygaF (gene name) | |
| 2.1.4.3 | L-arginine:L-lysine amidinotransferase | False | 1 | 0 | 0 | 1 | L-arginine + L-lysine = L-ornithine + L-homoarginine | L-arginine:L-lysine amidinotransferase | None | amtA (gene name) | |
| 2.3.1.292 | (phenol)carboxyphthiodiolenone synthase | False | 14 | 1 | 3 | 2 | (1) 3 malonyl-CoA + 2 (S)-methylmalonyl-CoA + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CoA + 5 NADP+ + 5 CO2 + 2 H2O;;(2) 3 malonyl-CoA + 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CoA + 5 NADP+ + 5 CO2 + 2 H2O;;(3) 3 malonyl-CoA + 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)-nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CoA + 5 NADP+ + 5 CO2 + 2 H2O;;(4) 3 malonyl-CoA + 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CoA + 5 NADP+ + 5 CO2 + 2 H2O | (methyl)malonyl-CoA:long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] (methyl)malonyltransferase {carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase]-forming} | None | ppsABCDE (gene names) | |
| 2.3.1.293 | meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I | False | 5 | 0 | 0 | 2 | an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + a holo-[acyl-carrier protein] | ultra-long-chain mono-unsaturated fattyl acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating) | None | kasA (gene name); beta-ketoacyl-acyl carrier protein synthase KasA | |
| 2.3.1.294 | meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II | False | 4 | 0 | 0 | 2 | an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + a holo-[acyl-carrier protein] | ultra-long-chain di-unsaturated fattyl acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating) | None | kasB (gene name); beta-ketoacyl-acyl carrier protein synthase KasB | |
| 2.3.1.295 | mycoketide-CoA synthase | False | 1 | 0 | 0 | 1 | a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ = a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O | malonyl-CoA/(S)-methylmalonyl-CoA:heptanoyl-CoA malonyltransferase (mycoketide-CoA-forming) | None | pks12 (gene name) | |
| 2.3.1.296 | omega-hydroxyceramide transacylase | False | 2 | 0 | 0 | 2 | a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide = a diacyl-sn-glycerol + a linoleate-esterified acylceramide | triacyl-sn-glycerol:ultra-long-chain omega-hydroxyceramide omega-O-linoleoyltransferase | None | PNPLA1 (gene name) | |
| 2.3.1.297 | very-long-chain ceramide synthase | False | 7 | 0 | 2 | 7 | a very-long-chain fatty acyl-CoA + a sphingoid base = a very-long-chain ceramide + CoA | very-long-chain fatty acyl-CoA:sphingoid base N-acyltransferase | None | sphingoid base N-very-long-chain fatty acyl-CoA transferase; mammalian ceramide synthase 2; CERS3 (gene name); LASS3 (gene name); LAG1 (gene name); LAC1 (gene name); LOH1 (gene name); LOH3 (gene name) | |
| 2.3.1.298 | ultra-long-chain ceramide synthase | False | 2 | 0 | 0 | 5 | an ultra-long-chain fatty acyl-CoA + a sphingoid base = an ultra-long-chain ceramide + CoA | ultra-long-chain fatty acyl-CoA:sphingoid base N-acyltransferase | None | mammalian ceramide synthase 3; sphingoid base N-ultra-long-chain fatty acyl-CoA transferase; CERS3 (gene name) | |
| 2.3.1.299 | sphingoid base N-stearoyltransferase | False | 2 | 1 | 0 | 3 | stearoyl-CoA + a sphingoid base = an N-(stearoyl)-sphingoid base + CoA | stearoyl-CoA:sphingoid base N-stearoyltransferase | None | mammalian ceramide synthase 1; LASS1 (gene name); UOG1 (gene name); CERS1 (gene name) | |
| 2.6.1.116 | 6-aminohexanoate aminotransferase | True | 0 | 0 | 0 | 4 | 6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate | 6-aminohexanoate:2-oxogutarate aminotransferase | None | nylD (gene name) | |
| 2.6.1.117 | L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase | False | 1 | 3 | 0 | 3 | L-glutamine + 4-(methylsulfanyl)-2-oxobutanoate = 2-oxoglutaramate + L-methionine | L-glutamine:4-(methylsulfanyl)-2-oxobutanoate aminotransferase | None | mtnE (gene name); Solyc11g013170.1 (locus name) | |
| 2.7.1.227 | inositol phosphorylceramide synthase | False | 3 | 0 | 0 | 10 | 1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine | 1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase | None | AUR1 (gene name); KEI1 (gene name) | |
| 2.7.1.228 | mannosyl-inositol-phosphoceramide inositolphosphotransferase | False | 1 | 0 | 0 | 1 | 1-phosphatidyl-1D-myo-inositol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(6-O-{6-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]-alpha-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine | 1-phosphatidyl-1D-myo-inositol:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine phosphoinositoltransferase | None | IPT1 (gene name) | |
| 2.7.1.229 | deoxyribokinase | False | 5 | 1848 | 0 | 2 | ATP + 2-deoxy-D-ribose = ADP + 2-deoxy-D-ribose 5-phosphate | ATP:2-deoxy-D-ribose 5-phosphotransferase | None | deoK (gene name) | |
| 2.8.1.16 | L-aspartate semialdehyde sulfurtransferase | False | 2 | 1 | 0 | 2 | hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase | None | MA1821 (locus name); MJ0100 (locus name) | |
| 3.1.1.110 | xylono-1,5-lactonase | False | 1 | 0 | 0 | 1 | D-xylono-1,5-lactone + H2O = D-xylonate | D-xylono-1,5-lactone lactonohydrolase | None | xylC (gene name); D-xylono-1,5-lactone lactonase | |
| 3.1.1.111 | phosphatidylserine sn-1 acylhydrolase | False | 9 | 319 | 0 | 2 | (1) a phosphatidylserine + H2O = a 2-acyl-1-lyso-phosphatidylserine + a fatty acid;;(2) a 1-acyl-2-lyso-phosphatidylserine + H2O = glycerophosphoserine + a fatty acid | 3-sn-phosphatidyl-L-serine sn-1 acylhydrolase | None | phosphatidylserine-specific phospholipase A1; PS-PLA1; PLA1A (gene name) | |
| 3.1.1.112 | isoamyl acetate esterase | False | 2 | 6 | 0 | 1 | 3-methylbutyl acetate + H2O = 3-methylbutanol + acetate | 3-methylbutyl acetate acetohydrolase | None | IAH1 (gene name) | |
| 3.1.1.113 | ethyl acetate hydrolase | False | 2 | 0 | 0 | 2 | ethyl acetate + H2O = acetate + ethanol | ethyl acetate acetohydrolase | None | mekB (gene name); estZ (gene name) | |
| 3.1.1.114 | methyl acetate hydrolase | False | 1 | 1 | 0 | 1 | methyl acetate + H2O = acetate + methanol | methyl acetate acetohydrolase | None | acmB (gene name) | |
| 3.2.1.210 | endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase | True | 0 | 0 | 0 | 2 | Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + H2O = Man7GlcNAc2-[protein] (isomer 7A1,2,3B3) + D-mannopyranose | Man8GlcNAc2-[protein] 2-alpha-mannohydrolase (configuration-inverting) | None | MNL1 (gene name) | |
| 3.4.13.23 | cysteinylglycine-S-conjugate dipeptidase | False | 8 | 1979 | 0 | 4 | an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine | cysteinylglycine-S-conjugate dipeptide hydrolase | None | tpdA (gene name); LAP3 (gene name) | |
| 3.5.1.134 | (indol-3-yl)acetyl-L-aspartate hydrolase | False | 1 | 0 | 0 | 2 | (indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate | (indol-3-yl)acetyl-L-aspartate amidohydrolase | None | indole-3-acetyl-L-aspartate hydrolase; iaaspH (gene name) | |
| 4.1.1.118 | isophthalyl-CoA decarboxylase | True | 0 | 0 | 0 | 1 | isophthalyl-CoA = benzoyl-CoA + CO2 | isophthalyl-CoA carboxy-lyase | None | IPCD | |
| 4.2.1.175 | (R)-3-(aryl)lactoyl-CoA dehydratase | False | 2 | 2 | 0 | 2 | (1) (R)-3-(phenyl)lactoyl-CoA = (E)-cinnamoyl-CoA + H2O;;(2) (R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O;;(3) (R)-3-(indol-3-yl)lactoyl-CoA = 3-(indol-3-yl)acryloyl-CoA + H2O | (R)-3-(aryl)lactoyl-CoA hydro-lyase | None | fldBC (gene names); (R)-phenyllactoyl-CoA dehydratase; aryllactyl-CoA dehydratase | |
| 4.2.3.205 | sodorifen synthase | True | 0 | 0 | 0 | 1 | pre-sodorifen diphosphate = sodorifen + diphosphate | pre-sodorifen diphosphate-lyase [sodorifen-forming] | None | sodD (gene name) | |
| 4.6.1.23 | ribotoxin | False | 2 | 1 | 0 | 6 | a 28S rRNA containing guanosine-adenosine pair + H2O = an [RNA fragment]-3'-adenosine-3'-phosphate + a 5'-a hydroxy-guanosine-3'-[RNA fragment] (overall reaction);;(1a) a 28S rRNA containing guanosine-adenosine pair = an [RNA fragment]-3'-adenosine-2',3'-cyclophosphate + a 5'-hydroxy-guanosine-3'-[RNA fragment];; (1b) an [RNA fragment]-3'-adenosine-2',3'-cyclophosphate + H2O = an [RNA fragment]-3'-adenosine-3'-phosphate | [28S-rRNA]-guanosine-adenosine 5'-hydroxy-guanosine-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'-adenosine-2',3'-cyclophosphate-forming and hydrolysing) | None | alpha-sarcin; rRNA endonuclease (ambiguous) | |
| 5.4.99.67 | 4-amino-4-deoxychorismate mutase | False | 2 | 0 | 0 | 2 | 4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate | 4-amino-4-deoxychorismate pyruvatemutase | None | cmlD (gene name); papB (gene name) | |
| 5.6.1.9 | (R)-2-hydroxyacyl-CoA dehydratase activating ATPase | False | 0 | 1 | 0 | 3 | 2 ATP + a reduced flavodoxin + an inactive (R)-2-hydroxyacyl-CoA dehydratase + 2 H2O = 2 ADP + 2 phosphate + a flavodoxin semiquinone + an active (R)-2-hydroxyacyl-CoA dehydratase | reduced flavodoxin:(R)-2-hydroxyacyl-CoA dehydratase electron transferase (ATP-hydrolyzing) | None | archerase; (R)-2-hydroxyacyl-CoA dehydratase activator; (R)-2-hydroxyacyl-CoA dehydratase activase; fldI (gene name); hgdC (gene name); hadI (gene name); lcdC (gene name) | |
| 6.2.1.58 | isophthalate---CoA ligase | True | 0 | 0 | 0 | 1 | ATP + isophthalate + CoA = AMP + diphosphate + isophthalyl-CoA | isophthalate:CoA ligase (AMP-forming) | None | IPCL | |
| 6.2.1.59 | long-chain fatty acid adenylase/transferase FadD26 | False | 4 | 0 | 0 | 2 | ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] (overall reaction);;(1a) ATP + a long-chain fatty acid = diphosphate + a long-chain fatty-acyl adenylate ester;;(1b) a long-chain fatty-acyl adenylate ester + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] | long-chain fatty acid:holo-[(phenol)carboxyphthiodiolenone synthase] ligase (AMP-forming) | None | FadD26 | |
| 6.2.1.60 | marinolic acid---CoA ligase | False | 1 | 0 | 0 | 1 | (1) ATP + a marinolic acid + CoA = AMP + diphosphate + a marinoloyl-CoA;;(2) ATP + a pseudomonic acid + CoA = AMP + diphosphate + a pseudomonoyl-CoA | marinolic acid:CoA ligase (AMP-forming) | None | tmlU (gene name) | |
| 7.2.2.21 | Cd2+-exporting ATPase | False | 19 | 11026 | 0 | 17 | ATP + H2O + Cd2+[side 1] = ADP + phosphate + Cd2+[side 2] | ATP phosphohydrolase (Cd2+-exporting) | None | cadmium-translocating P-type ATPase; cadmium-exporting ATPase | |
| 1.1.1.420 | D-apiose dehydrogenase | False | 2 | 0 | 0 | 2 | D-apiofuranose + NAD+ = D-apionolactone + NADH + H+ | D-apiofuranose:NAD+ 1-oxidoreductase | None | apsD (gene name) | |
| 1.1.1.421 | D-apionate oxidoisomerase | False | 4 | 0 | 0 | 4 | D-apionate + NAD+ = 3-oxoisoapionate + NADH + H+ | D-apionate:NAD+ oxidoreductase (isomerizing) | None | apnO (gene name) | |
| 1.1.2.10 | lanthanide-dependent methanol dehydrogenase | False | 1 | 1 | 0 | 30 | methanol + 2 oxidized cytochrome cL = formaldehyde + 2 reduced cytochrome cL | methanol:cytochrome cL oxidoreductase | None | XoxF; XoxF-MDH; Ce-MDH; La3+-dependent MDH; Ce3+-induced methanol dehydrogenase; cerium dependent MDH | |
| 1.2.1.103 | [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase | False | 23 | 1381 | 0 | 1 | an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine] + NADPH + H+ | [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine]:NADP+ 5-oxidoreductase (phosphorylating) | None | lysY (gene name) | |
| 1.3.1.121 | 4-amino-4-deoxyprephenate dehydrogenase | False | 2 | 0 | 0 | 2 | 4-amino-4-deoxyprephenate + NAD+ = 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+ | 4-amino-4-deoxyprephenate:NAD+ oxidoreductase (decarboxylating) | None | cmlC (gene name); papC (gene name) | |
| 1.3.1.122 | (S)-8-oxocitronellyl enol synthase | False | 8 | 1 | 0 | 9 | (S)-8-oxocitronellyl enol + NAD(P)+ = (6E)-8-oxogeranial + NAD(P)H + H+ | (S)-8-oxocitronellyl enol:NAD(P)+ oxidoreductase | None | CrISY; 8-oxogeranial:NAD(P)+ oxidoreductase (cyclizing, cis-trans-nepetalactol forming); iridoid synthase (incorrect) | |
| 1.3.1.123 | 8-oxogeranial reductase | False | 1 | 0 | 0 | 3 | (R)-8-oxocitronellyl enol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ | (R)-8-oxocitronellyl enol:NADP+ oxidoreductase | None | AmISY | |
| 1.3.8.15 | 3-(aryl)acrylate reductase | False | 1 | 1 | 0 | 1 | (1) phloretate + electron-transfer flavoprotein = 4-coumarate + reduced electron-transfer flavoprotein;;(2) 3-phenylpropanoate + electron-transfer flavoprotein = trans-cinnamate + reduced electron-transfer flavoprotein;;(3) 3-(1H-indol-3-yl)propanoate + electron-transfer flavoprotein = 3-(indol-3-yl)acrylate + reduced electron-transfer flavoprotein;; | 3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase | None | acdA (gene name) | |
| 1.8.4.15 | protein dithiol oxidoreductase (disulfide-forming) | False | 0 | 1 | 0 | 3 | a [DsbA protein] carrying a disulfide bond + a [protein] with reduced L-cysteine residues = a [DsbA protein] with reduced L-cysteine residues + a [protein] carrying a disulfide bond | protein dithiol:[DsbA protein] oxidoreductase (protein disulfide-forming) | None | dsbA (gene name) | |
| 1.8.4.16 | thioredoxin:protein disulfide reductase | False | 0 | 3 | 0 | 4 | a [protein] with reduced L-cysteine residues + thioredoxin disulfide = a [protein] carrying a disulfide bond + thioredoxin (overall reaction);;(1a) a [thioredoxin:protein disulfide reductase] with reduced L-cysteine residues + thioredoxin disulfide = a [thioredoxin:protein disulfide reductase] carrying a disulfide bond + thioredoxin;;(1b) a [thioredoxin:protein disulfide reductase] carrying a disulfide bond + a [protein] with reduced L-cysteine residues = a [thioredoxin:protein disulfide reductase] with reduced L-cysteine residues + a [protein] carrying a disulfide bond | thioredoxin:protein disulfide oxidoreductase (dithiol-forming) | None | dsbD (gene name); dipZ (gene name) | |
| 1.8.5.9 | protein dithiol:quinone oxidoreductase DsbB | False | 0 | 4 | 0 | 7 | a [DsbA protein] with reduced L-cysteine residues + a quinone = a [DsbA protein] carrying a disulfide bond + a quinol (overall reaction);;(1a) a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond = a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues;;(1b) a [DsbB protein] with reduced L-cysteine residues + a quinone = a [DsbB protein] carrying a disulfide bond + a quinol | protein dithiol:quinone oxidoreductase (disulfide-forming) | None | dsbB (gene name) | |
| 1.10.3.17 | superoxide oxidase | False | 3 | 9 | 0 | 4 | 2 O2 + ubiquinol = 2 superoxide + ubiquinone + 2 H+ | ubiquinol:oxygen oxidoreductase (superoxide-forming) | None | SOO; CybB; cytochrome b561; superoxide:ubiquinone oxidoreductase | |
| 1.14.11.70 | 7-deoxycylindrospermopsin hydroxylase | True | 0 | 0 | 0 | 3 | (1) 7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = cylindrospermopsin + succinate + CO2;;(2) 7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = 7-epi-cylindrospermopsin + succinate + CO2 | 7-deoxycylindrospermopsin,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating) | None | cyrI (gene name) | |
| 1.14.11.71 | methylphosphonate hydroxylase | False | 1 | 0 | 0 | 1 | methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2 | methylphosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating) | None | phnY* (gene name) | |
| 1.14.13.247 | stachydrine N-demethylase | True | 0 | 0 | 0 | 3 | L-proline betaine + NAD(P)H + H+ + O2 = N-methyl-L-proline + formaldehyde + NAD(P)+ + H2O | L-proline betaine,NAD(P)H:oxygen oxidoreductase (formaldehyde-forming) | None | L-proline betaine N-demethylase; stc2 (gene name) | |
| 2.1.1.363 | pre-sodorifen synthase | True | 0 | 0 | 0 | 1 | S-adenosyl-L-methionine + (2E,6E)-farnesyl diphosphate = S-adenosyl-L-homocysteine + pre-sodorifen diphosphate | (2E,6E)-farnesyl diphosphate 10-C-methyltransferase (cyclyzing, pre-sodorifen diphosphate producing) | None | sodC (gene name) | |
| 2.3.2.33 | RCR-type E3 ubiquitin transferase | False | 5 | 2094 | 0 | 3 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine (overall reaction);;(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;;(1b) [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type) | None | MYCBP2; PHR1 | |
| 2.4.1.371 | polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase | False | 2 | 0 | 0 | 0 | (1) 2 GDP-alpha-D-mannose + [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol = 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol;;(2) 2 GDP-alpha-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol = 2 GDP + [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n+1-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol | GDP-alpha-D-mannose:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosyltransferase (configuration-retaining) | None | WbdA | |
| 2.4.1.372 | mutansucrase | True | 0 | 0 | 0 | 2 | sucrose + [(1->3)-alpha-D-glucosyl]n = D-fructose + [(1->3)-alpha-D-glucosyl]n+1 | sucrose:(1->3)-alpha-D-glucan 3-alpha-D-glucosyltransferase | None | gtfJ (gene name) | |
| 2.4.1.373 | alpha-(1->2) branching sucrase | True | 0 | 0 | 0 | 2 | sucrose + a (1->6)-alpha-D-glucan = D-fructose + a (1->6)-alpha-D-glucan containing a (1->2)-alpha-D-glucose branch | sucrose:(1->6)-alpha-D-glucan 2-alpha-D-glucosyl-transferase | None | None | |
| 2.4.1.374 | beta-1,2-mannooligosaccharide synthase | True | 0 | 0 | 0 | 1 | GDP-alpha-D-mannose + [(1->2)-beta-D-mannosyl]n = GDP + [(1->2)-beta-D-mannosyl]n+1 | GDP-alpha-D-mannose:(1->2)-beta-D-mannan mannosyltransferase (configuration-inverting) | None | MTP1 (gene name); MTP2 (gene name) | |
| 2.6.1.118 | [amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase | False | 12 | 1126 | 0 | 1 | an [amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] + 2-oxoglutarate = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + L-glutamate | 2-oxoglutarate:[amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] aminotransferase | None | lysJ (gene name) | |
| 2.7.1.230 | amicoumacin kinase | False | 1 | 4 | 5 | 2 | ATP + amicoumacin A = ADP + amicoumacin A 2-phosphate | ATP:amicoumacin A 2-phosphotransferase | None | amiN (gene name); yerI (gene name) | |
| 2.7.2.16 | 2-phosphoglycerate kinase | False | 13 | 193 | 0 | 1 | ATP + 2-phospho-D-glycerate = ADP + 2,3-diphospho-D-glycerate | ATP:2-phosphoglycerate 3-phosphotransferase | None | pgk2 (gene name) | |
| 3.1.3.107 | amicoumacin phosphatase | True | 0 | 0 | 0 | 0 | amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate | amicoumacin 2-phosphate phosphohydrolase | None | amiO (gene name) | |
| 3.6.1.69 | 8-oxo-(d)GTP phosphatase | False | 4 | 2 | 0 | 2 | (1) 8-oxo-GTP + H2O = 8-oxo-GDP + phosphate;;(2) 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate | 8-oxo-dGTP diphosphohydrolase | None | mutT1 (gene name) | |
| 3.6.1.70 | guanosine-5'-diphospho-5'-[DNA] diphosphatase | False | 0 | 4 | 0 | 3 | guanosine-5'-diphospho-5'-[DNA] + H2O = phospho-5'-[DNA] + GMP | guanosine-5'-diphospho-5'-[DNA] hydrolase (guanosine 5'-phosphate-forming) | None | aprataxin; pp5'G5'DNA diphosphatase; pp5'G5'-DNA guanylate hydrolase; APTX (gene name); HNT3 (gene name) | |
| 3.6.1.71 | adenosine-5'-diphospho-5'-[DNA] diphosphatase | False | 15 | 979 | 0 | 7 | (1) adenosine-5'-diphospho-5'-[DNA] + H2O = AMP + phospho-5'-[DNA];;(2) adenosine-5'-diphospho-5'-(ribonucleotide)-[DNA] + H2O = AMP + 5'-phospho-(ribonucleotide)-[DNA] | adenosine-5'-diphospho-5'-[DNA] hydrolase (adenosine 5'-phosphate-forming) | None | aprataxin; 5'-App5'-DNA adenylate hydrolase; APTX (gene name); HNT3 (gene name) | |
| 3.6.1.72 | DNA-3'-diphospho-5'-guanosine diphosphatase | False | 15 | 980 | 0 | 2 | [DNA]-3'-diphospho-5'-guanosine + H2O = [DNA]-3'-phosphate + GMP | [DNA]-3'-diphospho-5'-guanosine hydrolase (guanosine 5'-phosphate-forming) | None | aprataxin; DNA-3'pp5'G guanylate hydrolase; APTX (gene name); HNT3 (gene name) | |
| 4.1.1.119 | phenylacetate decarboxylase | True | 0 | 0 | 0 | 1 | phenylacetate = toluene + CO2 | phenylacetate carboxy-lyase | None | phdB (gene name) | |
| 5.5.1.34 | (+)-cis,trans-nepetalactol synthase | False | 2 | 0 | 0 | 1 | (S)-8-oxocitronellyl enol = (+)-cis,trans-nepetalactol | (S)-8-oxocitronellyl enol cyclase [(+)-cis,trans-nepetalactol-forming] | None | NEPS1 (gene name); NEPS2 (gene name) | |
| 5.5.1.35 | (+)-cis,cis-nepetalactol synthase | False | 1 | 0 | 0 | 1 | (S)-8-oxocitronellyl enol = (+)-cis,cis-nepetalactol | (S)-8-oxocitronellyl enol cyclase [(+)-cis,cis-nepetalactol-forming] | None | NEPS3 (gene name) | |
| 6.2.1.61 | salicylate---[aryl-carrier protein] ligase | False | 3 | 0 | 0 | 2 | ATP + salicylate + holo-[non-ribosomal peptide synthase] = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] (overall reaction);;(1a) ATP + salicylate = diphosphate + (salicyl)adenylate;;(1b) (salicyl)adenylate + holo-[non-ribosomal peptide synthase] = AMP + salicyl-[non-ribosomal peptide synthase] | salicylate:holo-[non-ribosomal peptide synthase] ligase | None | pmsE (gene name); pchD (gene name) | |
| 7.1.1.9 | cytochrome-c oxidase | False | 757 | 1801534 | 42 | 147 | 4 ferrocytochrome c + O2 + 8 H+[side 1] = 4 ferricytochrome c + 2 H2O + 4 H+[side 2] | ferrocytochrome-c:oxygen oxidoreductase | None | cytochrome aa3; cytochrome caa3; cytochrome bb3; cytochrome cbb3; cytochrome ba3; cytochrome a3; Warburg's respiratory enzyme; indophenol oxidase; indophenolase; complex IV (mitochondrial electron transport); ferrocytochrome c oxidase; cytochrome oxidase (ambiguous); NADH cytochrome c oxidase (incorrect) | |
| 7.4.2.13 | ABC-type tyrosine transporter | False | 1 | 0 | 0 | 1 | ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1] = ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1] | ATP phosphohydrolase (ABC-type, L-tyrosine-importing) | None | None | |
| 1.1.1.422 | pseudoephedrine dehydrogenase | True | 0 | 0 | 0 | 1 | (+)-(1S,2S)-pseudoephedrine + NAD+ = (S)-2-(methylamino)-1-phenylpropan-1-one + NADH + H+ | (+)-(1S,2S)-pseudoephedrine:NAD+ 1-oxidoreductase | None | PseDH | |
| 1.1.1.423 | (1R,2S)-ephedrine 1-dehydrogenase | True | 0 | 0 | 0 | 1 | (-)-(1R,2S)-ephedrine + NAD+ = (S)-2-(methylamino)-1-phenylpropan-1-one + NADH + H+ | (-)-(1R,2S)-ephedrine:NAD+ 1-oxidoreductase | None | EDH; ephedrine dehydrogenase | |
| 1.1.98.7 | serine-type anaerobic sulfatase-maturating enzyme | False | 3 | 0 | 0 | 4 | S-adenosyl-L-methionine + a [sulfatase]-L-serine = a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine | [sulfatase]-L-serine:S-adenosyl-L-methionine oxidoreductase (3-oxo-L-alanine-forming) | None | atsB (gene name) | |
| 1.8.98.7 | cysteine-type anaerobic sulfatase-maturating enzyme | False | 3 | 0 | 0 | 2 | S-adenosyl-L-methionine + a [sulfatase]-L-cysteine + H2O = a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine + hydrogen sulfide | [sulfatase]-L-cysteine:S-adenosyl-L-methionine oxidoreductase (3-oxo-L-alanine-forming) | None | anSME; Cys-type anaerobic sulfatase-maturating enzyme; anaerobic sulfatase maturase | |
| 1.11.1.25 | glutaredoxin-dependent peroxiredoxin | False | 12 | 1847 | 0 | 6 | glutaredoxin + ROOH = glutaredoxin disulfide + H2O + ROH | glutaredoxin:hydroperoxide oxidoreductase | None | PRXIIB (gene name) | |
| 1.11.1.26 | NADH-dependent peroxiredoxin | False | 31 | 11530 | 1 | 7 | NADH + ROOH + H+ = NAD + H2O + ROH | NADH:hydroperoxide oxidoreductase | None | ahpC (gene name); ahpF (gene name); alkyl hydroperoxide reductase | |
| 1.11.1.27 | glutathione-dependent peroxiredoxin | False | 18 | 10613 | 0 | 12 | 2 glutathione + ROOH = glutathione disulfide + H2O + ROH | glutathione:hydroperoxide oxidoreductase | None | PRDX6 (gene name); prx3 (gene name) | |
| 1.11.1.28 | lipoyl-dependent peroxiredoxin | False | 62 | 3902 | 0 | 8 | a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH = a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine + H2O + ROH | [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine:hydroperoxide oxidoreductase | None | Ohr; ahpC (gene name); ahpD (gene name) | |
| 1.11.1.29 | mycoredoxin-dependent peroxiredoxin | False | 3 | 82 | 0 | 1 | mycoredoxin + ROOH = mycoredoxin disulfide + H2O + ROH | mycoredoxin:hydroperoxide oxidoreductase | None | ahpE (gene name) | |
| 1.14.18.12 | 2-hydroxy fatty acid dioxygenase | False | 2 | 0 | 0 | 1 | a (2R)-2-hydroxy Cn-fatty acid + O2 = a Cn-1-fatty acid + H2O + CO2 | 2-hydroxyfatty acid:oxygen oxidoreductase (CO2,H2O-forming) | None | MPO1 (gene name) | |
| 1.17.99.8 | limonene dehydrogenase | False | 2 | 0 | 0 | 1 | (1) (S)-limonene + H2O + acceptor = (-)-perillyl alcohol + reduced acceptor;;(2) (R)-limonene + H2O + acceptor = (+)-perillyl alcohol + reduced acceptor | limonene:acceptor oxidoreductase (7-hydroxylating) | None | ctmAB (gene names) | |
| 2.7.2.17 | [amino-group carrier protein]-L-2-aminoadipate 6-kinase | False | 25 | 1455 | 0 | 2 | ATP + an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] = ADP + an [amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine} | [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] 5-O-kinase | None | lysZ (gene name); [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine 5-O-kinase; [amino group carrier protein]-L-2-aminoadipate 6-kinase | |
| 2.8.3.26 | succinyl-CoA:mesaconate CoA transferase | False | 2 | 4 | 0 | 1 | succinyl-CoA + mesaconate = 2-methylfumaryl-CoA + succinate | succinyl-CoA:mesaconate CoA transferase | None | mct (gene name) | |
| 2.9.1.3 | tRNA 2-selenouridine synthase | False | 102 | 3045 | 0 | 12 | selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O = 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate (overall reaction);;(1a) geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA = 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA + diphosphate;;(1b) selenophosphate + 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA = 5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol;;(1c) 5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + H2O = 5-methylaminomethyl-2-selenouridine34 in tRNA + phosphate | geranyl diphosphate/selenophosphate:tRNA 5-methylaminomethyl-2-thiouridine34 geranyl/selenophosphatetransferase | None | selU (gene name); mnmH (gene name); ybbB (gene name); sufY (gene name) | |
| 3.1.3.108 | nocturnin | False | 3 | 0 | 0 | 7 | (1) NADPH + H2O = NADH + phosphate;;(2) NADP+ + H2O = NAD+ + phosphate | NADPH 2'-phosphohydrolase | None | NOCT (gene name); nocturnin (curled); MJ0109 (gene name); NADP phosphatase; NADPase | |
| 3.2.1.211 | endo-(1->3)-fucoidanase | False | 0 | 0 | 1 | 3 | endohydrolysis of (1->3)-alpha-L-fucoside linkages in fucan | poly[(1->3)-alpha-L-fucoside-2/4-sulfate] glycanohydrolase | None | alpha-L-fucosidase (incorrect); poly(1,3-alpha-L-fucoside-2/4-sulfate) glycanohydrolase | |
| 3.2.1.212 | endo-(1->4)-fucoidanase | False | 0 | 0 | 1 | 5 | endohydrolysis of (1->4)-alpha-L-fucoside linkages in fucan | poly[(1->4)-alpha-L-fucoside-2/3-sulfate] glycanohydrolase | None | alpha-L-fucosidase (incorrect); poly(1,4-alpha-L-fucoside-2/3-sulfate) glycanohydrolase | |
| 3.2.1.213 | galactan exo-1,6-beta-galactobiohydrolase (non-reducing end) | False | 1 | 0 | 0 | 1 | Hydrolysis of (1->6)-beta-D-galactosidic linkages in arabinogalactan proteins and (1->3):(1->6)-beta-galactans to yield (1->6)-beta-galactobiose as the final product. | exo-beta-(1->6)-galactobiohydrolase (non-reducing end) | None | exo-beta-1,6-galactobiohydrolase; 1,6Gal (gene name) | |
| 3.4.17.24 | tubulin-glutamate carboxypeptidase | False | 17 | 3542 | 0 | 4 | This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin. | None | None | cytosolic carboxypeptidase 5; CCP5; Agtpbp1 (gene name); AGBL5 (gene name) | |
| 3.6.1.73 | inosine/xanthosine triphosphatase | False | 87 | 5791 | 0 | 1 | (1) inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate;;(2) xanthosine 5'-triphosphate + H2O = xanthosine 5'-diphosphate + phosphate | inosine/xanthosine 5'-triphosphate phosphohydrolase | None | yjjX (gene name) | |
| 3.7.1.26 | 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase | False | 0 | 1 | 0 | 1 | 2,4-didehydro-3-deoxy-L-rhamnonate + H2O = pyruvate + (S)-lactate | 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase | None | L-2,4-diketo-3-deoxyrhamnonate hydrolase; lra6 (gene name) | |
| 3.13.1.9 | S-inosyl-L-homocysteine hydrolase | False | 6 | 334 | 1 | 1 | S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine | S-inosyl-L-homocysteine hydrolase (inosine-forming) | None | SIHH | |
| 4.1.2.61 | feruloyl-CoA hydratase/lyase | False | 1 | 163 | 0 | 17 | feruloyl-CoA + H2O = vanillin + acetyl-CoA (overall reaction);;(1a) feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA;;(1b) 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA | feruloyl-CoA hydro-lyase/vanillin-lyase (acetyl-CoA-forming) | None | hydroxycinnamoyl-CoA hydratase lyase; enoyl-CoA hydratase/aldolase; HCHL; ferB (gene name); couA (gene name) | |
| 4.2.2.27 | pectin monosaccharide-lyase | True | 0 | 0 | 0 | 1 | (1,4-alpha-D-galacturonosyl methyl ester)n = (1,4-alpha-D-galacturonosyl methyl ester)n-1 + 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate | poly(1,4-alpha-D-galacturonosyl methyl ester) non-reducing-end-monosaccharide-lyase | None | exo-pectin lyase; PLIII | |
| 4.6.1.24 | ribonuclease T1 | False | 20 | 1462 | 1 | 23 | [RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment] (overall reaction);;(1a) [RNA] containing guanosine = [RNA fragment]-3'-guanosine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment];; (1b) [RNA fragment]-3'-guanosine-2',3'-cyclophosphate + H2O = [RNA fragment]-3'-guanosine-3'-phosphate | [RNA]-guanosine 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'-guanosine-2',3'-cyclophosphate-forming and hydrolysing) | None | barnase; bacterial ribonuclease Sa; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N1 | |
| 4.6.1.25 | bacteriophage T4 restriction endoribonuclease RegB | True | 0 | 0 | 0 | 1 | a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate (overall reaction);;(1a) a [pre-mRNA]-containing guanosine-adenosine + H2O = a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-adenosine-2',3'-cyclophosphate;;(1b) a [pre-mRNA fragment]- adenosine-2',3'-cyclophosphate + H2O = a [pre-mRNAfragment]-3'-adenosine-3'-phosphate | [pre-mRNA]-guanosine-adenosine 5'-hydroxy-guanosine-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- adenosine -2',3'-cyclophosphate-forming and hydrolysing) | None | RegB | |
| 6.2.1.62 | 3,4-dihydroxybenzoate---[aryl-carrier protein] ligase | False | 1 | 1 | 0 | 1 | ATP + 3,4-dihydroxybenzoate + holo-[aryl-carrier protein] = AMP + diphosphate + 3,4-dihydroxybenzoyl-[aryl-carrier protein] (overall reaction);;(1a) ATP + 3,4-dihydroxybenzoate = diphosphate + (3,4-dihydroxybenzoyl)adenylate;;(1b) (3,4-dihydroxybenzoyl)adenylate + holo-[aryl-carrier protein] = AMP + 3,4-dihydroxybenzoyl-[aryl-carrier protein] | 3,4-dihydroxybenzoate:[aryl-carrier protein] ligase (AMP-forming) | None | asbC (gene name) | |
| 6.2.1.63 | L-arginine---[L-arginyl-carrier protein] ligase | False | 1 | 0 | 0 | 1 | ATP + L-arginine + holo-[L-arginyl-carrier protein] = AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein] (overall reaction);;(1a) ATP + L-arginine = diphosphate + (L-arginyl)adenylate;;(1b) (L-arginyl)adenylate + holo-[L-arginyl-carrier protein] = AMP + L-arginyl-[L-arginyl-carrier protein] | L-arginine:[L-arginyl-carrier protein] ligase (AMP-forming) | None | vabF (gene name) | |
| 1.1.7.1 | 4-hydroxybenzoyl-CoA reductase | False | 3 | 106 | 0 | 8 | benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin | benzoyl-CoA:oxidized ferredoxin oxidoreductase | None | 4-hydroxybenzoyl-CoA reductase (dehydroxylating); 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase; benzoyl-CoA:acceptor oxidoreductase | |
| 1.3.1.124 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] | False | 12 | 5064 | 0 | 7 | (1) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+;;(2) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4Z)-2,4-dienoyl-CoA + NADPH + H+ | (3E)-3-enoyl-CoA:NADP+ 4-oxidoreductase | None | SPS19 (gene name); DECR1 (gene name); DECR2 (gene name); Delta2,Delta4-dienoyl-CoA reductase (ambiguous) | |
| 1.8.2.7 | thiocyanate desulfurase | True | 0 | 0 | 0 | 4 | thiocyanate + 2 ferricytochrome c + H2O = cyanate + sulfur + 2 ferrocytochrome c + 2 H+ | thiocyanate:cytochrome c oxidoreductase (cyanate and sulfur-forming) | None | TcDH; thiocyanate dehydrogenase | |
| 1.11.2.6 | L-tyrosine peroxygenase | True | 0 | 0 | 0 | 2 | L-tyrosine + H2O2 = L-dopa + H2O | L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming) | None | None | |
| 1.13.11.90 | [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming) | False | 1 | 0 | 0 | 1 | [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + phosphate | [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate:oxygen 1R-oxidoreductase (glycine-betaine-forming) | None | tmpB (gene name) | |
| 1.14.11.72 | [2-(trimethylamino)ethyl]phosphonate dioxygenase | False | 1 | 0 | 0 | 1 | [2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2 | [2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating) | None | tmpA (gene name) | |
| 1.14.14.172 | 3,5,6-trichloropyridin-2-ol monooxygenase | True | 0 | 0 | 0 | 2 | (1) 3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + Cl- + FAD + H2O;;(2) 3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + Cl- + FAD + H2O;;(3) 6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + Cl- + FAD + H2O | 3,5,6-trichloropyridin-2-ol,FADH2:oxygen oxidoreductase (dechlorinating) | None | tcpA (gene name) | |
| 1.14.14.173 | 2,4,6-trichlorophenol monooxygenase | False | 1 | 0 | 0 | 3 | 2,4,6-trichlorophenol + FADH2 + O2 = 6-chloro-2-hydroxy-1,4-benzoquinone + 2 Cl- + FAD (overall reaction);;(1a) 2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichloro-1,4-benzoquinone + Cl- + FAD + H2O;;(1b) 2,6-dichloro-1,4-benzoquinone + H2O = 6-chloro-2-hydroxy-1,4-benzoquinone + Cl- | 2,4,6-trichlorophenol,FADH2:oxygen oxidoreductase (dechlorinating) | None | tcpA (gene name) | |
| 1.14.19.77 | plasmanylethanolamine desaturase | False | 4 | 2 | 0 | 6 | a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O | plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming) | None | TMEM189 (gene name); 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase; alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; alkyl-acylglycerophosphorylethanolamine dehydrogenase; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase | |
| 2.1.1.364 | [histone H3]-lysine4 N-methyltransferase | False | 21 | 4136 | 3 | 2 | S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4 | S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase | None | KMT7 (gene name); SETD7 (gene name); SET7/9 (gene name); KIAA1717 (gene name); KMT2A (gene name); KMT2B (gene name); KMT2C (gene name); KMT2D (gene name); KMT2F (gene name); KMT2G (gene name); MLL1 (gene name); MLL2 (gene name); MLL3 (gene name); MLL4 (gene name); SETD1A (gene name) | |
| 2.1.1.365 | MMP 1-O-methyltransferase | False | 1 | 1 | 0 | 1 | S-adenosyl-L-methionine + 3,3'-di-O-methyl-4alpha-mannobiose = S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4alpha-mannobiose | S-adenosyl-L-methionine:3,3'-di-O-methyl-4alpha-mannobiose 1-O-methyltransferase | None | MeT1; 3-O-methylmannose polysaccharide 1-O-methyltransferase | |
| 2.3.2.34 | E2 NEDD8-conjugating enzyme | False | 23 | 1401 | 0 | 2 | [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine | [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine:[E2 NEDD8-conjugating enzyme] [NEDD8-protein]-yl transferase | None | NEDD8-carrier-protein E2; NEDD8-conjugating enzyme E2; UBE2M (gene name); UBE2F (gene name) | |
| 2.3.2.35 | capsaicin synthase | False | 3 | 0 | 0 | 3 | (6E)-8-methylnon-6-enoyl-CoA + vanillylamine = CoA + capsaicin | (6E)-8-methylnon-6-enoyl-CoA:vanillylamine 8-methylnon-6-enoyltransferase | None | CS (gene name) (ambiguous); Pun1 (locus name) | |
| 2.4.1.375 | rhamnogalacturonan I galactosyltransferase | True | 0 | 0 | 0 | 3 | Transfer of a beta-galactosyl residue in a beta-(1->4) linkage from UDP-alpha-D-galactose to rhamnosyl residues within the rhamnogalacturonan I backbone. | UDP-alpha-D-galactose:[rhamnogalacturonan I]-alpha-L-rhamnosyl beta-1,4-galactosyltransferase (configuration-inverting) | None | None | |
| 2.4.1.376 | EGF-domain serine glucosyltransferase | False | 4 | 1 | 0 | 3 | UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine | UDP-alpha-D-glucose:[protein with EGF-like domain]-L-serine O-beta-glucosyltransferase (configuration-inverting) | None | POGLUT1 (gene name) (ambiguous); rumi (gene name) (ambiguous) | |
| 2.4.2.62 | xylosyl alpha-1,3-xylosyltransferase | False | 2 | 1 | 0 | 2 | UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine | UDP-alpha-D-xylose:[EGF-like domain protein]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining) | None | XXYLT1 (gene name) | |
| 2.4.2.63 | EGF-domain serine xylosyltransferase | False | 4 | 1 | 0 | 3 | UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine | UDP-alpha-D-xylose:[protein with EGF-like domain]-L-serine O-beta-xylosyltransferase (configuration-inverting) | None | POGLUT1 (gene name) (ambiguous); rumi (gene name) (ambiguous) | |
| 2.6.1.119 | vanillin aminotransferase | False | 3 | 0 | 0 | 3 | L-alanine + vanillin = pyruvate + vanillylamine | L-alanine:vanillin aminotransferase | None | VAMT (gene name) | |
| 2.7.1.231 | 3-oxoisoapionate kinase | False | 1 | 2 | 0 | 1 | ATP + 3-oxoisoapionate = ADP + 3-oxoisoapionate 4-phosphate | ATP:3-oxoisoapionate 4-phosphotransferase | None | oiaK (gene name) | |
| 2.7.4.33 | AMP-polyphosphate phosphotransferase | False | 3 | 3 | 0 | 9 | ADP + (phosphate)n = AMP + (phosphate)n+1 | ADP:polyphosphate phosphotransferase | None | PA3455 (locus name); PPK2D; PAP | |
| 2.7.7.104 | 2-hydroxyethylphosphonate cytidylyltransferase | False | 1 | 0 | 0 | 1 | 2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate | CTP:2-hydroxyethylphosphonate cytidylyltransferase | None | Fom1 | |
| 3.2.1.214 | exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end) | False | 1 | 0 | 0 | 1 | [(1->2)-beta-D-glucosyl]n + H2O = sophorose + [(1->2)-beta-D-glucosyl]n-2 | exo (1->2)-beta-D-glucooligosaccharide sophorohydrolase (non-reducing end) | None | None | |
| 4.1.1.120 | 3-oxoisoapionate decarboxylase | False | 1 | 0 | 0 | 1 | 3-oxoisoapionate = L-erythrulose + CO2 | 3-oxoisoapionate carboxy-lyase | None | oiaC (gene name) | |
| 4.1.1.121 | 3-oxoisoapionate-4-phosphate decarboxylase | False | 2 | 1 | 0 | 1 | 3-oxoisoapionate 4-phosphate = L-erythrulose 1-phosphate + CO2 | 3-oxoisoapionate 4-phosphate carboxy-lyase | None | oiaX (gene name) | |
| 4.1.2.62 | 5-deoxyribulose 1-phosphate aldolase | False | 2 | 1 | 0 | 4 | (1) 5-deoxy-D-ribulose 1-phosphate = glycerone phosphate + acetaldehyde;;(2) S-methyl-5-thio-D-ribulose 1-phosphate = glycerone phosphate + (2-methylsulfanyl)acetaldehyde | 5-deoxy-D-ribulose 1-phosphate acetaldehyde-lyase (glycerone-phosphate-forming) | None | 5-(methylthio)ribulose-1-phosphate aldolase; ald2 (gene name) | |
| 6.2.1.64 | E1 NEDD8-activating enzyme | False | 11 | 4907 | 0 | 5 | ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine | [NEDD8 protein]:[E1 NEDD8-activating enzyme] ligase (AMP-forming) | None | NEDD-activating enzyme E1; NAE1 (gene name); UBA3 (gene name) | |
| 6.2.2.1 | thioglycine synthase | True | 0 | 0 | 0 | 4 | ATP + sulfide + a [methyl-coenzyme M reductase]-glycine = ADP + phosphate + a [methyl-coenzyme M reductase]-thioglycine | [methyl-coenzyme M reductase]-glycine---sulfur ligase (thioglycine-forming) | None | ycaO (gene name) (ambiguous) | |
| 6.5.1.9 | cyclic 2,3-diphosphoglycerate synthase | False | 13 | 178 | 2 | 3 | ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate | (2R)-2,3-bisphosphoglycerate ligase (cyclizing) | None | cpgS (gene name) | |
| 1.1.1.424 | D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) | False | 2 | 1 | 0 | 2 | D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ | D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming) | None | xacA (gene name); xdh (gene name) | |
| 1.3.3.16 | oxazoline dehydrogenase | True | 0 | 0 | 0 | 3 | (1) a [protein]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole + H2O2;;(2) a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole + H2O2;;(3) a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole + H2O2 | a [protein]-2-oxazoline:oxygen oxidoreductase (2-oxazole-forming) | None | azoline oxidase; thiazoline oxidase; cyanobactin oxidase; patG (gene name); mcaG (gene name); artG (gene name); lynG (gene name); tenG (gene name) | |
| 1.14.11.73 | [protein]-arginine 3-hydroxylase | False | 4 | 0 | 1 | 1 | [protein]-L-arginine + 2-oxoglutarate + O2 = [protein]-(3R)-3-hydroxy-L-arginine + succinate + CO2 | [protein]-L-arginine,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating) | None | JMJD5 (gene name) | |
| 1.14.11.74 | L-isoleucine 31-dioxygenase | False | 1 | 0 | 0 | 1 | L-isoleucine + 2-oxoglutarate + O2 = 31-hydroxy-L-isoleucine + succinate + CO2 | L-isoleucine,2-oxoglutarate:oxygen oxidoreductase (31-hydroxylating) | None | hilA (gene name); L-isoleucine 4'-dioxygenase (incorrect) | |
| 1.14.11.75 | 31-hydroxy-L-isoleucine 4-dioxygenase | False | 1 | 0 | 0 | 1 | 31-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (4S)-31,4-dihydroxy-L-isoleucine + succinate + CO2 | 31-hydroxy-L-isoleucine,2-oxoglutarate:oxygen oxidoreductase (4S-hydroxylating) | None | hilB (gene name); 4'-hydroxy-L-isoleucine 4-dioxygenase (incorrect) | |
| 1.14.14.174 | geranylhydroquinone 3''-hydroxylase | False | 1 | 0 | 0 | 2 | geranylhydroquinone + [reduced NADPH---hemoprotein reductase] + O2 = 3''-hydroxygeranylhydroquinone + [oxidized NADPH---hemoprotein reductase] + H2O | geranylhydroquinone,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3''-hydroxylating) | None | GHQ 3''-hydroxylase; CYP76B74 (gene name); geranylhydroquinone,NADPH:oxygen oxidoreductase (3''-hydroxylating) | |
| 1.14.14.175 | ferruginol synthase | False | 5 | 0 | 0 | 4 | abieta-8,11,13-triene + [reduced NADPH---hemoprotein reductase] + O2 = ferruginol + [oxidized NADPH---hemoprotein reductase] + H2O | abieta-8,11,13-triene,[reduced NADPH---hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming) | None | miltiradiene oxidase (incorrect); CYP76AH1; miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) (incorrect) | |
| 1.14.14.176 | taxadiene 5alpha-hydroxylase | False | 1 | 0 | 2 | 3 | taxa-4,11-diene + [reduced NADPH---hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH---hemoprotein reductase] + H2O | taxa-4,11-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5alpha-hydroxylating) | None | None | |
| 1.17.9.2 | (+)-pinoresinol hydroxylase | True | 0 | 0 | 0 | 1 | (+)-pinoresinol + 2 oxidized azurin + H2O = (+)-6-hydroxypinoresinol + 2 reduced azurin + 2 H+ | (+)-pinoresinol:azurin oxidoreductase | None | pinoresinol alpha-hydroxylase; pinAB (gene names) | |
| 2.1.1.366 | [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase | False | 13 | 897 | 1 | 2 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine9 N6-methyltransferase | None | KMT1E (gene name); SETDB1 (gene name); KIAA0067 (gene name) | |
| 2.1.1.367 | [histone H3]-lysine9 N-methyltransferase | False | 22 | 0 | 0 | 5 | S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase | None | PRDM3 (gene name); PRDM16 (gene name) | |
| 2.1.1.368 | [histone H3]-lysine9 N-dimethyltransferase | False | 2 | 0 | 0 | 4 | 2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-dimethyltransferase | None | SUVH1 (gene name); SUVR1 (gene name); SET32 (gene name); SDG32 (gene name); SET13 (gene name) | |
| 2.1.1.369 | [histone H3]-lysine27 N-methyltransferase | False | 4 | 0 | 0 | 3 | S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27 | S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase | None | ATXR5 (gene name) | |
| 2.1.1.370 | [histone H3]-lysine4 N-dimethyltransferase | False | 2 | 0 | 0 | 2 | 2 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4 | S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-dimethyltransferase | None | NSD3 (gene name) | |
| 2.1.1.371 | [histone H3]-lysine27 N-dimethyltransferase | False | 2 | 0 | 0 | 2 | 2 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;;(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27 | S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-dimethyltransferase | None | NSD3 (gene name) | |
| 2.1.1.372 | [histone H4]-lysine20 N-trimethyltransferase | False | 16 | 2232 | 0 | 2 | 3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = 3 S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20 (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20;;(1b) S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20;;(1c) S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20;; | S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-trimethyltransferase | None | SET9 (gene name) | |
| 2.7.7.105 | phosphoenolpyruvate guanylyltransferase | False | 44 | 3206 | 0 | 5 | phosphoenolpyruvate + GTP = enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate | GTP:phosphoenolpyruvate guanylyltransferase | None | fbiD (gene name) | |
| 2.7.7.106 | 3-phospho-D-glycerate guanylyltransferase | False | 4 | 612 | 1 | 2 | 3-phospho-D-glycerate + GTP = 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate | GTP:3-phospho-D-glycerate guanylyltransferase | None | cofC (gene name) (ambiguous) | |
| 6.2.1.65 | salicylate---CoA ligase | False | 1 | 0 | 0 | 2 | ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction);;(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate;;(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA | salicylate:CoA ligase (AMP-forming) | None | sdgA (gene name) | |
| 6.2.2.2 | oxazoline synthase | True | 0 | 0 | 0 | 4 | (1) ATP + a [protein]-(L-amino acyl-L-serine) = ADP + phosphate + a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline;;(2) ATP + a [protein]-(L-amino acyl-L-threonine) = ADP + phosphate + a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline;;(3) ATP + a [protein]-(L-amino acyl-L-cysteine) = ADP + phosphate + a [protein]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline | [protein]-(L-amino acyl-L-serine) cyclodehydratase (2-oxazoline-forming) | None | cyanobactin heterocyclase; cyanobactin cyclodehydratase; patD (gene name); balhD (gene name); micD (gene name) | |
| 6.2.2.3 | thiazoline synthase | True | 0 | 0 | 0 | 2 | ATP + a [protein]-(L-amino acyl-L-cysteine) = ADP + phosphate + a [protein]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline | [protein]-(L-amino acyl-L-cysteine) cyclodehydratase (2-thiazoline-forming) | None | None | |
| 1.2.1.104 | pyruvate dehydrogenase system | True | 0 | 0 | 0 | 44 | pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH | pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating) | None | pyruvate dehydrogenase complex; PDH | |
| 1.2.1.105 | 2-oxoglutarate dehydrogenase system | True | 0 | 0 | 0 | 27 | 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH | 2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating) | None | 2-oxoglutarate dehydrogenase complex | |
| 1.3.8.16 | 2-amino-4-deoxychorismate dehydrogenase | False | 1 | 8 | 0 | 1 | (2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2 | (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase | None | ADIC dehydrogenase; 2-amino-2-deoxyisochorismate dehydrogenase; SgcG | |
| 1.4.1.27 | glycine cleavage system | True | 0 | 0 | 0 | 15 | glycine + tetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH | glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding) | None | GCV | |
| 1.4.3.26 | pre-mycofactocin synthase | False | 4 | 29 | 0 | 4 | 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + O2 + H2O = 5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidine-2,3-dione + NH3 + H2O2 (overall reaction);;(1a) 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O2;;(1b) 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O = 5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidine-2,3-dione + NH3 (spontaneous) | 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one:oxygen oxidoreductase | None | mftD (gene name) | |
| 1.13.11.91 | 3-mercaptopropionate dioxygenase | False | 1 | 4 | 0 | 4 | 3-sulfanylpropanoate + O2 = 3-sulfinopropanoate | 3-sulfanylpropanoate:oxygen oxidoreductase | None | mdo (gene name); 3-mercaptopropionic acid dioxygenase; 3-sulfanylpropanoate dioxygenase | |
| 1.14.11.76 | L-glutamate 3(R)-hydroxylase | False | 1 | 0 | 0 | 1 | L-glutamate + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-glutamate + succinate + CO2 | L-glutamate,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating) | None | iboH (gene name) | |
| 1.14.15.38 | N,N-dimethyl phenylurea N-demethylase | False | 2 | 0 | 0 | 1 | an N,N-dimethyl-N'-phenylurea compound + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = an N-methyl-N'-phenylurea compound + formaldehyde + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | N,N-dimethyl-N'-phenylurea compound,NAD(P)H:oxygen oxidoreductase (formaldehyde-forming) | None | pdmAB (gene names) | |
| 1.14.99.67 | alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase | False | 1 | 0 | 0 | 1 | alpha-N-dichloroacetyl-p-aminophenylserinol + reduced acceptor + 2 O2 = chloramphenicol + acceptor + 2 H2O | alpha-N-dichloroacetyl-p-aminophenylserinol,acceptor:oxygen oxidoreductase (N-hydroxylating) | None | cmlI (gene name) | |
| 1.14.99.68 | 4-aminobenzoate N-oxygenase | False | 1 | 0 | 0 | 1 | 4-aminobenzoate + reduced acceptor + 2 O2 = 4-nitrobenzoate + acceptor + 2 H2O | 4-aminobenzoate,acceptor:oxygen oxidoreductase (N-hydroxylating) | None | aurF (gene name) | |
| 1.14.99.69 | tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase | False | 2 | 1 | 0 | 2 | 2-(methylsulfanyl)-N6-prenyladenosine37 in tRNA + reduced acceptor + O2 = N6-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine37 in tRNA + acceptor + H2O | tRNA 2-(methylsulfanyl)-N6-prenyladenosine37,donor:oxygen 4-oxidoreductase (trans-hydroxylating) | None | miaE (gene name); tRNA 2-methylthio-N6-isopentenyl adenosine(37) hydroxylase; tRNA 2-(methylsulfanyl)-N6-dimethylallyladenosine37 hydroxylase | |
| 1.17.98.4 | formate dehydrogenase (hydrogenase) | False | 1 | 7 | 1 | 5 | formate + an [oxidized hydrogenase] = CO2 + a [reduced hydrogenase] | formate:[oxidized hydrogenase] oxidoreductase | None | FDHH; FDH-H; FDH-O; formate dehydrogenase H; formate dehydrogenase O | |
| 1.17.99.9 | heme a synthase | False | 167 | 5982 | 0 | 9 | ferroheme o + H2O + 2 acceptor = ferroheme a + 2 reduced acceptor (overall reaction);;(1a) ferroheme o + H2O + acceptor = ferroheme i + reduced acceptor;;(1b) ferroheme i + H2O + acceptor = hydroxyferroheme i + reduced acceptor;;(1c) hydroxyferroheme i = ferroheme a + H2O (spontaneous) | ferroheme o:acceptor C-81-oxidoreductase (heme a-forming) | None | COX15 (gene name); ctaA (gene name) | |
| 1.17.99.10 | steroid C-25 hydroxylase | True | 0 | 0 | 0 | 2 | cholest-4-en-3-one + acceptor + H2O = 25-hydroxycholest-4-en-3-one + reduced acceptor | cholest-4-en-3-one:acceptor oxidoreductase (25-hydroxylating) | None | s25dA1 (gene name); s25dA1B3 (gene name); s25dA1C3 (gene name); cholesterol C-25 dehydrogenase; steroid C-25 dehydrogenase | |
| 1.17.99.11 | 3-oxo-Delta1-steroid hydratase/dehydrogenase | True | 0 | 0 | 0 | 1 | a 3-oxo-Delta1-steroid + H2O + acceptor = a steroid 1,3-dione + reduced acceptor (overall reaction);;(1a) a 3-oxo-Delta1-steroid + H2O = a 1-hydroxy-3-oxo-steroid;;(1b) a 1-hydroxy-3-oxo-steroid + acceptor = a steroid 1,3-dione + reduced acceptor | 3-oxo-Delta1-steroid:acceptor 1-oxidoreductase | None | atcABC (gene names) | |
| 2.1.1.373 | 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase | True | 0 | 0 | 0 | 16 | S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate = S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate | S-adenosyl-L-methionine:(2R)-2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase | None | dsyB (gene name); methylthiohydroxybutyrate methyltransferase; MTHB methyltransferase | |
| 2.1.1.374 | 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase | False | 5 | 0 | 1 | 2 | S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one = S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | S-adenosyl-L-methionine:2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase | None | htm (gene name) | |
| 2.2.1.13 | apulose-4-phosphate transketolase | False | 4 | 0 | 0 | 2 | apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + glycerone phosphate | apulose-4-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase | None | aptAB (gene names) | |
| 2.3.2.36 | RING-type E3 ubiquitin transferase (cysteine targeting) | False | 20 | 2331 | 0 | 1 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (thioester bond-froming; RING-type) | None | RING E3 ligase (misleading) | |
| 2.5.1.153 | adenosine tuberculosinyltransferase | False | 2 | 0 | 0 | 1 | tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate | tuberculosinyl-diphosphate:adenosine tuberculosinyltransferase | None | Rv3378c (locus name) | |
| 3.1.1.115 | D-apionolactonase | False | 1 | 1 | 0 | 1 | D-apionolactone + H2O = D-apionate | D-apionolactone lactonohydrolase | None | apnL (gene name) | |
| 3.5.1.136 | N,N'-diacetylchitobiose non-reducing end deacetylase | False | 1 | 0 | 1 | 3 | N,N'-diacetylchitobiose + H2O = beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + acetate | N,N'-diacetylchitobiose non-reducing end acetylhydrolase | None | diacetylchitobiose deacetylase (ambiguous); cda (gene name) | |
| 5.1.3.44 | mannose 2-epimerase | True | 0 | 0 | 0 | 2 | beta-D-mannopyranose = beta-D-glucopyranose | beta-D-mannopyranose 2-epimerase | None | None | |
| 5.3.1.36 | D-apiose isomerase | False | 1 | 0 | 0 | 1 | D-apiose = apulose | D-apiose isomerase | None | apsI (gene name) | |
| 1.1.1.425 | levoglucosan dehydrogenase | False | 1 | 0 | 0 | 3 | levoglucosan + NAD+ = 3-dehydrolevoglucosan + NADH + H+ | 1,6-anhydro-beta-D-glucopyranose:NAD+ 3-oxidoreductase | None | 1,6-anhydro-beta-D-glucose dehydrogenase | |
| 1.2.1.106 | [amino-group carrier protein]-5-phospho-L-glutamate reductase | False | 20 | 960 | 0 | 3 | an [amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H+ | [amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate:NADP+ 5-oxidoreductase (phosphorylating) | None | lysY (gene name) | |
| 1.3.8.17 | dehydro coenzyme F420 reductase | False | 14 | 1131 | 0 | 4 | oxidized coenzyme F420-0 + FMN = dehydro coenzyme F420-0 + FMNH2 | oxidized coenzyme F420-0:FMN oxidoreductase | None | fbiB (gene name) | |
| 1.3.98.7 | [mycofactocin precursor peptide]-tyrosine decarboxylase | False | 4 | 0 | 0 | 3 | C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine | C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine L-tyrosine-carboxylyase | None | mftC (gene name) | |
| 1.5.1.54 | methylenetetrahydrofolate reductase (NADH) | False | 16 | 22039 | 0 | 7 | 5-methyltetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NADH + H+ | 5-methyltetrahydrofolate:NAD+ oxidoreductase | None | metF (gene name); 5,10-methylenetetrahydrofolic acid reductase (ambiguous); 5,10-CH2-H4folate reductase (ambiguous); methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase; 5,10-methylenetetrahydrofolate reductase (ambiguous); methylenetetrahydrofolate reductase (ambiguous); N5,10-methylenetetrahydrofolate reductase (ambiguous); 5,10-methylenetetrahydropteroylglutamate reductase (ambiguous); N5,N10-methylenetetrahydrofolate reductase (ambiguous); methylenetetrahydrofolic acid reductase (ambiguous); 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect); 5,10-methylenetetrahydrofolate reductase (FADH2) (ambiguous) | |
| 1.14.14.177 | ultra-long-chain fatty acid omega-hydroxylase | False | 1 | 0 | 0 | 1 | an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O | ultra-long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating) | None | CYP4F22 (gene name) | |
| 1.14.15.39 | epi-isozizaene 5-monooxygenase | False | 1 | 3 | 0 | 1 | (+)-epi-isozizaene + 4 reduced [2Fe-2S] ferredoxin + 4 H+ + 2 O2 = albaflavenone + 4 oxidized [2Fe-2S] ferredoxin + 3 H2O (overall reaction);;(1a) (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = (5S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O;;(1b) (5S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O;;(2a) (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = (5R)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O;;(2b) (5R)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O | (+)-epi-isozizaene,reduced-ferredoxin:oxygen oxidoreductase (5-hydroxylating) | None | CYP170A1 | |
| 1.14.19.78 | decanoyl-[acyl-carrier protein] acetylenase | False | 1 | 0 | 0 | 1 | decanoyl-[acyl-carrier protein] + 4 reduced ferredoxin [iron-sulfur] cluster + 2 O2 + 4 H+ = dec-9-ynoyl-[acyl-carrier protein] + 4 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O (overall reaction);;(1a) decanoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = dec-9-enoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(1b) dec-9-enoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = dec-9-ynoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O | decanoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (9,10-dehydrogenating) | None | ttuB (gene name) (ambiguous) | |
| 2.1.1.375 | NNS virus cap methyltransferase | False | 78 | 4126 | 1 | 2 | 2 S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = 2 S-adenosyl-L-homocysteine + m7G(5')pppAmACA-[mRNA] (overall reaction);;(1a) S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5')pppAmACA-[mRNA];;(1b) S-adenosyl-L-methionine + G(5')pppAmACA-[mRNA] = S-adenosyl-L-homocysteine + m7G(5')pppAmACA-[mRNA] | S-adenosyl-L-methionine:G(5')pppAACA-[mRNA] N7,2'-O-methyltransferase | None | None | |
| 2.2.1.14 | 6-deoxy-6-sulfo-D-fructose transaldolase | False | 2 | 0 | 0 | 1 | 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + beta-D-fructofuranose 6-phosphate | 6-deoxy-6-sulfo-D-fructose:D-glyceraldehyde-3-phosphate glyceronetransferase | None | sftT (gene name) | |
| 2.3.1.301 | mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III | False | 10 | 128 | 0 | 1 | dodecanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxotetradecanoyl-[acyl-carrier protein] + CoA + CO2 | dodecanoyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase | None | fabH (gene name) (ambiguous); mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III | |
| 2.3.1.302 | hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase | False | 2 | 0 | 0 | 2 | (1) (E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA;;(2) (E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA | hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase | None | HHT1 (gene name); HHT4 (gene name) | |
| 2.3.1.303 | alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2IV-O-acetyltransferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = CoA + 2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und | acetyl-CoA:alpha-L-rhamnopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2IV-O-acetyltransferase | None | rfbL (gene name); wbaL (gene name) | |
| 2.4.1.377 | dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase | False | 2 | 0 | 0 | 1 | dTDP-beta-L-rhamnose + alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol = dTDP + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und | dTDP-beta-L-rhamnose:alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-rhamnosyltransferase (configuration-inverting) | None | wbaN (gene name); rfbN (gene name) | |
| 2.4.1.378 | GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase | False | 1 | 0 | 0 | 1 | GDP-alpha-D-mannose + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = GDP + alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und | GDP-alpha-D-mannose:alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 4II-alpha-rhamnosyltransferase (configuration-retaining) | None | wbaU (gene name); rfbU (gene name) | |
| 2.4.1.379 | GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase | True | 0 | 0 | 0 | 1 | GDP-alpha-D-mannose + alpha-D-galactosyl-diphospho-ditrans-octacis-undecaprenol = GDP + alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und | GDP-alpha-D-mannose:alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining) | None | wbaZ (gene name); rfbZ (gene name) | |
| 2.4.1.380 | GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase | True | 0 | 0 | 0 | 1 | GDP-alpha-D-mannose + alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und | GDP-alpha-D-mannose:alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2II-alpha-mannosyltransferase (configuration-retaining) | None | wbaW (gene name); rfbW (gene name) | |
| 2.4.1.381 | dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rhamnosyltransferase | True | 0 | 0 | 0 | 1 | dTDP-beta-L-rhamnose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = dTDP + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und | dTDP-beta-L-rhamnose:alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2III-alpha-rhamnosyltransferase (configuration-inverting) | None | wbaQ (gene name); rfbQ (gene name) | |
| 2.4.1.382 | CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase | True | 0 | 0 | 0 | 1 | CDP-alpha-D-abequose + 2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = CDP + alpha-D-Abe-(1->3)-2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und | CDP-alpha-D-abequose:2-O-acetyl-alpha-L-rhamnopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3IV-alpha-abequosyltransferase (configuration retaining) | None | wbaR (gene name); rfbR (gene name) | |
| 2.4.1.383 | GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase | True | 0 | 0 | 0 | 0 | GDP-alpha-D-mannose + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = GDP + beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und | GDP-alpha-D-mannose:alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 4II-beta-mannosyltransferase (configuration inverting) | None | wbaO (gene name); rfbO (gene name) | |
| 2.7.1.232 | levoglucosan kinase | False | 1 | 0 | 0 | 11 | ATP + levoglucosan + H2O = ADP + D-glucose 6-phosphate | ATP:1,6-anhydro-beta-D-glucopyranose 6-phosphotransferase (hydrolyzing) | None | None | |
| 2.7.4.34 | GDP-polyphosphate phosphotransferase | False | 1 | 0 | 0 | 8 | GTP + (phosphate)n = GDP + (phosphate)n+1 | GTP:polyphosphate phosphotransferase | None | ppk2 (gene name); polyphosphate kinase 2 | |
| 3.1.1.116 | sn-1-specific diacylglycerol lipase | False | 12 | 8083 | 0 | 2 | a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid | diacylglycerol sn-1-acylhydrolase | None | DAGLA (gene name); DAGLB (gene name) | |
| 3.1.1.117 | (4-O-methyl)-D-glucuronate---lignin esterase | False | 12 | 5301 | 0 | 35 | a 4-O-methyl-D-glucopyranuronate ester + H2O = 4-O-methyl-D-glucuronic acid + an alcohol | (4-O-methyl)-D-glucuronate---lignin ester hydrolase | None | glucuronoyl esterase (ambiguous); 4-O-methyl-glucuronoyl methylesterase; glucuronoyl-lignin ester hydrolase | |
| 3.1.4.61 | cyclic 2,3-diphosphoglycerate hydrolase | True | 0 | 0 | 0 | 1 | cyclic 2,3-bisphosphoglycerate + H2O = 2,3-diphosphoglycerate | cyclic 2,3-diphosphoglycerate phosphohydrolyase | None | None | |
| 3.6.1.74 | mRNA 5'-phosphatase | False | 58 | 3624 | 3 | 5 | a 5'-triphospho-[mRNA] + H2O = a 5'-diphospho-[mRNA] + phosphate | 5'-triphospho-mRNA 5'-phosphohydrolase | None | 5'-polynucleotidase; polynucleotide 5'-phosphohydrolase; RNGTT (gene name); CET1 (gene name); mRNA 5'-triphosphate monophosphatase | |
| 4.1.99.26 | 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase | False | 4 | 0 | 0 | 4 | C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 | C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one lyase (C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol-forming) | None | mftC (gene name) | |
| 5.3.3.23 | S-methyl-5-thioribulose 1-phosphate isomerase | False | 1 | 0 | 0 | 1 | (1) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate;;(2) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-ribulose 5-phosphate | S-methyl-5-thio-D-ribulose 1-phosphate 1,3-isomerase | None | rlp (gene name); 5-methylthioribulose-1-phosphate isomerase (incorrect) | |
| 6.2.1.66 | glyine---[glycyl-carrier protein] ligase | False | 2 | 0 | 0 | 2 | ATP + glycine + holo-[glycyl-carrier protein] = AMP + diphosphate + glycyl-[glycyl-carrier protein] (overall reaction);;(1a) ATP + glycine = diphosphate + (glycyl)adenylate;;(1b) (glycyl)adenylate + holo-[glycyl-carrier protein] = AMP + glycyl-[glycyl-carrier protein] | glycine:[glycyl-carrier protein] ligase (AMP-forming) | None | dhbF (gene name); sfmB (gene name) | |
| 6.2.1.67 | L-alanine---[L-alanyl-carrier protein] ligase | False | 3 | 0 | 3 | 3 | ATP + L-alanine + holo-[L-alanyl-carrier protein] = AMP + diphosphate + L-alanyl-[L-alanyl-carrier protein] (overall reaction);;(1a) ATP + L-alanine = diphosphate + (L-alanyl)adenylate;;(1b) (L-alanyl)adenylate + holo-[L-alanyl-carrier protein] = AMP + L-alanyl-[L-alanyl-carrier protein] | L-alanine:[L-alanyl-carrier protein] ligase (AMP-forming) | None | ambB (gene name); phsB (gene name) | |
| 6.2.1.68 | L-glutamate---[L-glutamyl-carrier protein] ligase | False | 1 | 0 | 0 | 1 | ATP + L-glutamate + holo-[L-glutamyl-carrier protein] = AMP + diphosphate + L-glutamyl-[L-glutamyl-carrier protein] (overall reaction);;(1a) ATP + L-glutamate = diphosphate + (L-glutamyl)adenylate;;(1b) (L-glutamyl)adenylate + holo-[L-glutamyl-carrier protein] = AMP + L-glutamyl-[L-glutamyl-carrier protein] | L-glutamate:[L-glutamyl-carrier protein] ligase (AMP-forming) | None | ambE (gene name) | |
| 6.3.1.21 | phosphoribosylglycinamide formyltransferase 2 | False | 225 | 9797 | 0 | 3 | ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide | formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming) | None | purT (gene name); GAR transformylase 2; GART2; glycinamide ribonucleotide transformylase 2; 5'-phosphoribosylglycinamide transformylase 2; GAR transformylase T | |
| 6.3.2.59 | 3-methyl-D-ornithine---L-lysine ligase | False | 3 | 0 | 0 | 7 | ATP + (3R)-3-methyl-D-ornithine + L-lysine = ADP + phosphate + N6-[(3R)-3-methyl-D-ornithinyl]-L-lysine | (3R)-3-methyl-D-ornithine:L-lysine gamma-ligase (ADP-forming) | None | N6-[(2R,3R)-3-methylornithyl]-L-lysine synthase; 3-methylornithine---L-lysine ligase; pylC (gene name) | |
| 6.3.2.60 | glutamate---[amino group carrier protein] ligase | True | 0 | 0 | 0 | 2 | ATP + L-glutamate + an [amino-group carrier protein]-C-terminal-L-glutamate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate | L-glutamate:an [amino-group carrier protein]-C-terminal-L-glutamate ligase (ADP-forming) | None | argX (gene name) | |
| 7.1.1.10 | ferredoxin---quinone oxidoreductase (H+-translocating) | True | 0 | 0 | 0 | 8 | 2 reduced ferredoxin [iron-sulfur] cluster + plastoquinone + 6 H+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + plastoquinol + 7 H+[side 2] | ferredoxin:quinone oxidoreductase (H+-translocating) | None | NDH-1L complex; NDH-1L' complex; NDH11 complex; NDH12 complex | |
| 7.2.2.22 | P-type Mn2+ transporter | False | 4 | 0 | 0 | 4 | ATP + H2O + Mn2+[side 1] = ADP + phosphate + Mn2+[side 2] | ATP phosphohydrolase (P-type, Mn2+-exporting) | None | Mn(II)-translocating P-type ATPase; Mn2+-exporting ATPase; P1B-type ATPase (ambiguous); ctpC (gene name) | |
| 7.4.2.14 | ABC-type antigen peptide transporter | False | 7 | 625 | 0 | 10 | ATP + H2O + antigen peptide[side 1] = ADP + phosphate + antigen peptide[side 2] | ATP phosphohydrolase (ABC-type, antigen peptide-exporting) | None | TAP1 (gene name); TAP2 (gene name) | |
| 1.1.1.426 | UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase | True | 0 | 0 | 0 | 2 | UDP-N-acetyl-alpha-D-quinovosamine + NAD(P)+ = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NAD(P)H + H+ | UDP-N-acetyl-alpha-D-quinovosamine:NAD(P)+ 4-dehydrogenase | None | wbpV (gene name); wreQ (gene name) | |
| 1.1.5.14 | fructose 5-dehydrogenase | False | 1 | 9 | 0 | 5 | D-fructose + a ubiquinone = 5-dehydro-D-fructose + a ubiquinol | D-fructose:ubiquinone 5-oxidoreductase | None | fructose 5-dehydrogenase (acceptor); D-fructose dehydrogenase; D-fructose:(acceptor) 5-oxidoreductase | |
| 1.2.1.107 | glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) | True | 0 | 0 | 0 | 13 | D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+ | D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring) | None | None | |
| 1.13.11.92 | fatty acid alpha-dioxygenase | False | 4 | 3 | 0 | 9 | a fatty acid + O2 = a (2R)-2-hydroperoxyfatty acid | fatty acid:oxygen 2-oxidoreductase [(2R)-2-hydroperoxyfatty acid-forming] | None | DOX1 (gene name) | |
| 1.14.11.77 | alkyl sulfatase | False | 4 | 0 | 0 | 2 | a primary alkyl sulfate ester + 2-oxoglutarate + O2 = an aldehyde + succinate + CO2 + sulfate | primary alkyl sulfate ester, 2-oxoglutarate:oxygen oxidoreductase (sulfate-hydrolyzing) | None | atsK (gene name); alpha-ketoglutarate-dependent sulfate ester dioxygenase; 2-oxoglutarate-dependent sulfate ester dioxygenase; type II alkyl sulfatase | |
| 1.16.99.1 | [Co(II) methylated amine-specific corrinoid protein] reductase | False | 1 | 0 | 0 | 2 | (1) ATP + a [Co(II) methylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) methylamine-specific corrinoid protein] + acceptor;;(2) ATP + a [Co(II) dimethylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) dimethylamine-specific corrinoid protein] + acceptor;;(3) ATP + a [Co(II) trimethylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) trimethylamine-specific corrinoid protein] + acceptor;; | acceptor:[cobalt(II) methylated amines-specific corrinoid protein] oxidoreductase (ATP-hydrolysing) | None | None | |
| 2.1.1.376 | glycine betaine---corrinoid protein Co-methyltransferase | False | 1 | 0 | 0 | 2 | glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] | glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase | None | mtgB (gene name); glycine betaine methyltransferase | |
| 2.1.1.377 | [methyl-Co(III) glycine betaine-specific corrinoid protein]---coenzyme M methyltransferase | True | 0 | 0 | 0 | 1 | a [methyl-Co(III) glycine betaine-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) glycine betaine-specific corrinoid protein] | methylated glycine betaine-specific corrinoid protein:CoM methyltransferase | None | mtaA (gene name) | |
| 2.1.1.378 | [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase | False | 1 | 0 | 0 | 1 | a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate | [methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase | None | mtgA (gene name); DSY3157 (locus name) | |
| 2.1.1.379 | [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase | False | 2 | 0 | 0 | 2 | 2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine + reduced acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine + acceptor | S-adenosyl-L-methionine:[methyl coenzyme M reductase]-L-arginine C-5-(S)-methyltransferase | None | methanogenesis marker protein 10; Mmp10 | |
| 2.1.2.14 | GDP-perosamine N-formyltransferase | False | 2 | 0 | 0 | 1 | 10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine | 10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase | None | wbkC (gene name) | |
| 2.4.1.384 | NDP-glycosyltransferase | False | 2 | 0 | 0 | 2 | an NDP-glycose + an acceptor = a glycosylated acceptor + NDP | NDP-glycose:acceptor glycosyltransferase | None | yjiC (gene name) | |
| 2.7.1.233 | apulose kinase | False | 1 | 0 | 0 | 1 | ATP + apulose = ADP + apulose 4-phosphate | ATP:apulose 4-phosphotransferase | None | aplK (gene name) | |
| 2.7.2.18 | fatty acid kinase | True | 0 | 0 | 0 | 3 | ATP + a fatty acid = ADP + a fatty acyl phosphate (overall reaction);;(1a) ATP + a fatty acid-[fatty acid-binding protein] = ADP + a fatty acyl phosphate-[fatty acid-binding protein];;(1b) a fatty acyl phosphate-[fatty acid-binding protein] + a fatty acid = a fatty acyl phosphate + a fatty acid-[fatty acid-binding protein] | ATP:fatty acid 1-phosphotransferase | None | fakAB (gene names) | |
| 2.8.2.40 | omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase | False | 3 | 0 | 0 | 1 | 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + omega-sulfo-beta-dihydromenaquinone-9 | 3'-phosphoadenylyl-sulfate:omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase | None | stf3 (gene name) | |
| 3.1.1.118 | phospholipid sn-1 acylhydrolase | False | 3 | 0 | 0 | 6 | (1) a 1-phosphatidyl-1D-myo-inositol + H2O = a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol + a fatty acid;;(2) a 1,2-diacyl-sn-glycerol 3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid | phospholipid sn-1 acylhydrolase | None | phospholipase DDHD1; phosphatidic acid-preferring phospholipase A1; PA-PLA1; DDHD1 (gene name) | |
| 3.1.6.21 | linear primary-alkylsulfatase | False | 4 | 1 | 0 | 4 | a primary alkyl sulfate ester + H2O = an alcohol + sulfate | primary alkyl sulfate ester sulfohydrolase | None | sdsA1 (gene name); yjcS (gene name); type III linear primary-alkylsulfatase | |
| 3.1.6.22 | branched primary-alkylsulfatase | True | 0 | 0 | 0 | 1 | 2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + sulfate | branched primary-alkyl sulfate ester sulfohydrolase | None | DP1 (gene name); type III branched primary-alkylsulfatase | |
| 3.1.21.10 | crossover junction endodeoxyribonuclease | False | 687 | 41488 | 1 | 41 | Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction) | None | None | Hje endonuclease; Holliday junction endonuclease CCE1; Holliday junction resolvase; Holliday junction-cleaving endonuclease; Holliday junction-resolving endoribonuclease; RusA Holliday junction resolvase; RusA endonuclease; RuvC endonuclease; SpCCe1 Holliday junction resolvase; crossover junction endoribonuclease; cruciform-cutting endonuclease; endo X3; endonuclease RuvC; endonuclease VII; endonuclease X3; resolving enzyme CCE1 | |
| 3.4.14.14 | [mycofactocin precursor peptide] peptidase | False | 4 | 0 | 0 | 3 | C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O = C-terminal [mycofactocin precursor peptide]-glycine + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one | C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one hydrolyase | None | mftE (gene name) | |
| 3.7.1.28 | 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase | False | 1 | 0 | 0 | 1 | 3-oxoisoapionate 4-phosphate + H2O = glycolate + 3-phospho-D-glycerate | 3-oxoisoapionate-4-phosphate transcarboxylase/glycolylhydrolase (3-phospho-D-glycerate-forming) | None | oiaT (gene name) | |
| 4.1.2.63 | 2-hydroxyacyl-CoA lyase | False | 8 | 3090 | 0 | 3 | (1) a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA = a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA;;(2) a (2R)-2-hydroxy-Cn-long-chain fatty acyl-CoA = a Cn-1-long-chain fatty aldehyde + formyl-CoA | 2-hydroxy-3-methyl fatty-CoA formyl-CoA lyase (2-methyl branched fatty aldehyde-forming) | None | HACL1 (gene name); 2-hydroxyphytanoyl-CoA lyase; 2-HPCL | |
| 4.2.1.176 | L-lyxonate dehydratase | True | 0 | 0 | 0 | 2 | L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O | L-lyxonate hydro-lyase | None | lyxD (gene name) | |
| 4.2.1.177 | (2S)-3-sulfopropanediol dehydratase | False | 1 | 0 | 0 | 1 | (2S)-2,3-dihydroxypropane-1-sulfonate = 3-oxopropane-1-sulfonate + H2O | (2S)-2,3-dihydroxypropane-1-sulfonate hydro-lyase | None | hpfG (gene name); (S)-DHPS dehydratase | |
| 4.4.1.38 | isethionate sulfite-lyase | False | 4 | 0 | 0 | 3 | isethionate = acetaldehyde + sulfite | isethionate sulfite-lyase | None | islA (gene name) | |
| 4.4.1.39 | C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase | True | 0 | 0 | 0 | 3 | a [C-phycoerythrin alpha-subunit]-Cys82-phycoerythrobilin = apo-[C-phycoerythrin alpha-subunit] + (3E)-phycoerythrobilin | [C-phycoerythrin alpha-subunit]-Cys82-phycoerythrobilin:phycoerythrobilin lyase | None | cpeY (gene name) | |
| 4.4.1.40 | C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase | True | 0 | 0 | 0 | 1 | a [C-phycoerythrin beta-subunit]-Cys48/59-phycoerythrobilin = apo-[C-phycoerythrin beta-subunit] + (3E)-phycoerythrobilin | [C-phycoerythrin beta-subunit]-Cys48/59-phycoerythrobilin:phycoerythrobilin lyase | None | cpeF (gene name) | |
| 4.4.1.41 | (2S)-3-sulfopropanediol sulfolyase | False | 1 | 0 | 0 | 1 | (2S)-2,3-dihydroxypropane-1-sulfonate = hydroxyacetone + sulfite | (2S)-2,3-dihydroxypropane-1-sulfonate sulfite-lyase | None | DHPS sulfolyase; hpsG (gene name) | |
| 6.2.1.69 | L-cysteine---[L-cysteinyl-carrier protein] ligase | False | 4 | 0 | 0 | 1 | ATP + L-cysteine + holo-[L-cysteinyl-carrier protein] = AMP + diphosphate + L-cysteinyl-[L-cysteinyl-carrier protein] (overall reaction);;(1a) ATP + L-cysteine = diphosphate + (L-cysteinyl)adenylate;;(1b) (L-cysteinyl)adenylate + holo-[L-cysteinyl-carrier protein] = AMP + L-cysteinyl-[L-cysteinyl-carrier protein] | L-cysteine:[L-cysteinyl-carrier protein] ligase (AMP-forming) | None | pchE (gene name); pchF (gene name); angR (gene name) | |
| 6.2.1.70 | L-threonine---[L-threonyl-carrier protein] ligase | False | 3 | 0 | 0 | 2 | ATP + L-threonine + holo-[L-threonyl-carrier protein] = AMP + diphosphate + L-threonyl-[L-threonyl-carrier protein] (overall reaction);;(1a) ATP + L-threonine = diphosphate + (L-threonyl)adenylate;;(1b) (L-threonyl)adenylate + holo-[L-threonyl-carrier protein] = AMP + L-threonyl-[L-threonyl-carrier protein] | L-threonine:[L-threonyl-carrier protein] ligase (AMP-forming) | None | dhbF (gene name); pmsD (gene name); syrB1 (gene name) | |
| 6.2.1.71 | 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase | False | 4 | 41 | 0 | 3 | ATP + 2,3-dihydroxybenzoate + holo-[aryl-carrier protein] = AMP + diphosphate + 2,3-dihydroxybenzoyl-[aryl-carrier protein] (overall reaction);;(1a) ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate;;(1b) (2,3-dihydroxybenzoyl)adenylate + holo-[aryl-carrier protein] = AMP + 2,3-dihydroxybenzoyl-[aryl-carrier protein] | 2,3-dihydroxybenzoate:[aryl-carrier protein] ligase (AMP-forming) | None | entE (gene name); vibE (gene name); dhbE (gene name); angE (gene name) | |
| 6.2.1.72 | L-serine---[L-seryl-carrier protein] ligase | False | 5 | 0 | 0 | 2 | ATP + L-serine + holo-[L-seryl-carrier protein] = AMP + diphosphate + L-seryl-[L-seryl-carrier protein] (overall reaction);;(1a) ATP + L-serine = diphosphate + (L-seryl)adenylate;;(1b) (L-seryl)adenylate + holo-[L-seryl-carrier protein] = AMP + L-seryl-[L-seryl-carrier protein] | L-serine:[L-seryl-carrier protein] ligase (AMP-forming) | None | entF (gene name); zmaJ (gene name); gdnB (gene name); serine-activating enzyme | |
| 6.2.1.73 | L-tryptophan---[L-tryptophyl-carrier protein] ligase | True | 0 | 0 | 0 | 1 | ATP + L-tryptophan + holo-[L-tryptophyl-carrier protein] = AMP + diphosphate + -L-tryptophyl-[L-tryptophyl-carrier protein] (overall reaction);;(1a) ATP + tryptophan = diphosphate + (L-tryptophyl)adenylate;;(1b) (L-tryptophyl)adenylate + holo-[L-tryptophyl-carrier protein] = AMP + L-tryptophyl-[L-tryptophyl-carrier protein] | L-tryptophan:[L-tryptophyl-carrier protein] ligase (AMP-forming) | None | ecm13 (gene name); swb11 (gene name) | |
| 6.2.1.74 | 3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase | True | 0 | 0 | 0 | 2 | ATP + 3-amino-5-hydroxybenzoate + a holo-[acyl-carrier protein] = 3-amino-5-hydroxybenzoyl-[acyl-carrier protein] + AMP + diphosphate | 3-amino-5-hydroxybenzoate:[acyl carrier protein] ligase (AMP-forming) | None | rifA (gene name); mitE (gene name) | |
| 6.3.4.25 | 2-amino-2'-deoxyadenylo-succinate synthase | False | 4 | 125 | 0 | 4 | ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate | dGMP:L-aspartate ligase (ADP-forming) | None | purZ (gene name) | |
| 7.1.1.11 | ferredoxin---NAD+ oxidoreductase (H+-transporting) | True | 0 | 0 | 0 | 3 | 2 reduced ferredoxin [iron-sulfur] cluster + NAD+ + H+ + 2 H+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + NADH + 2 H+[side 2] | ferredoxin:NAD+ oxidoreductase (H+-transporting) | None | Rnf complex (ambiguous); H+-translocating ferredoxin:NAD+ oxidoreductase | |
| 1.7.2.9 | hydroxylamine oxidase | False | 2 | 0 | 0 | 2 | hydroxylamine + 3 ferricytochrome c = nitric oxide + 3 ferrocytochrome c + 3 H+ | hydroxylamine:ferricytochrome-c oxidoreductase (nitric acid-forming) | None | HOX | |
| 1.14.13.248 | L-aspartate N-monooxygenase (nitrosuccinate-forming) | False | 2 | 0 | 0 | 2 | L-aspartate + 3 NADPH + 3 H+ + 3 O2 = (2S)- 2-nitrobutanedioate + 3 NADP+ + 4 H2O;;(1a) L-aspartate + NADPH + H+ + O2 = N-hydroxy-L-aspartate + NADP+ + H2O;;(1b) N-hydroxy-L-aspartate + NADPH + H+ + O2 = N,N-dihydroxy-L-aspartate + NADP+ + H2O;;(1c) N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O (spontaneous);;(1d) (2S)-2-nitrosobutanedioate + NADPH + H+ + O2 = (2S)-2-nitrobutanedioate + NADP+ + H2O | L-aspartate,NADPH:oxygen oxidoreductase [(2S)-2-nitrobutanedioate-forming] | None | creE (gene name) | |
| 1.14.13.249 | 3-amino-4-hydroxybenzoate 2-monooxygenase | False | 3 | 0 | 0 | 2 | 3-amino-4-hydroxybenzoate + NADPH + H+ + O2 = 3-amino-2,4-dihydroxybenzoate + NADP+ + H2O | 3-amino-4-hydroxybenzoate,NADPH:oxygen oxidoreductase (2-hydroxylating) | None | creL (gene name); ptmB3 (gene name); ptnB3 (gene name) | |
| 1.14.13.250 | nitrosourea synthase | False | 1 | 0 | 0 | 1 | Nomega-methyl-L-arginine + 2 NADH + 2 H+ + 3 O2 = Ndelta-hydroxy-Nomega-methyl-Nomega-nitroso-L-citrulline + 2 NAD+ + 3 H2O (overall reaction);;(1a) Nomega-methyl-L-arginine + NADH + H+ + O2 = Ndelta-hydroxy-Nomega-methyl-L-arginine + NAD+ + H2O;;(1b) Ndelta-hydroxy-Nomega-methyl-L-arginine + NADH + H+ + O2 = Ndelta,Nomega'-dihydroxy-Nomega-methyl-L-arginine + NAD+ + H2O;;(1c) Ndelta,Nomega'-dihydroxy-Nomega-methyl-L-arginine + O2 = Ndelta-hydroxy-Nomega-methyl-Nomega-nitroso-L-citrulline + H2O | Nomega-methyl-L-arginine,NADH:oxygen oxidoreductase (Ndelta-hydroxy-Nomega-methyl-Nomega-nitroso-L-citrulline-forming) | None | sznF (gene name); StzF | |
| 1.16.3.4 | cuproxidase | False | 10 | 2877 | 0 | 8 | 4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O | copper(I):oxygen oxidoreductase | None | cueO (gene name); cuprous oxidase; Cu(I) oxidase; copper efflux oxidase | |
| 2.1.1.380 | 3-amino-4-hydroxybenzoate 4-O-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + 3-amino-2,4-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-amino-2-hydroxy-4-methoxybenzoate | S-adenosyl-L-methionine:3-amino-4-hydroxybenzoate 4-O-methyltransferase | None | creN (gene name) | |
| 2.1.1.381 | arginine Nomega-methyltransferase | False | 1 | 0 | 0 | 1 | S-adenosyl-L-methionine + L-arginine = S-adenosyl-L-homocysteine + Nomega-methyl-L-arginine | S-adenosyl-L-methionine:L-arginine Nomega-methyltransferase | None | sznE (gene name); stzE (gene name) | |
| 2.1.1.383 | L-carnitine---corrinoid protein Co-methyltransferase | False | 1 | 0 | 0 | 1 | L-carnitine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + L-norcarnitine | L-carnitine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase | None | mtcB (gene name) | |
| 2.1.3.16 | ureidoglycine carbamoyltransferase | False | 1 | 0 | 0 | 1 | carbamoyl phosphate + (S)-(carbamoylamino)glycine = phosphate + allantoate | carbamoyl phosphate:(S)-(carbamoylamino)glycine carbamoyltransferase | None | UGTCase | |
| 2.3.1.305 | acyl-[acyl-carrier protein]---UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase | True | 0 | 0 | 0 | 3 | a (3R)-3-hydroxyacyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = an [acyl-carrier protein] + a UDP-2-acetamido-2,3-dideoxy-3-{[(3R)-3-hydroxyacyl]amino}-alpha-D-glucopyranose | (3R)-3-hydroxyacyl-[acyl-carrier-protein]:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose 3-N-[(3R)-hydroxyacyl]transferase | None | lpxA (gene name) (ambiguous) | |
| 2.3.1.306 | acetyl-CoA:lysine N6-acetyltransferase | False | 1 | 0 | 0 | 4 | acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine | acetyl-CoA:L-lysine N6-acetyltransferase | None | LYC1 (gene name); lysine N6-acetyltransferase (ambiguous) | |
| 2.3.1.307 | 6-diazo-5-oxo-L-norleucine Nalpha-acetyltranferase | True | 0 | 0 | 0 | 1 | acetyl-CoA + 6-diazo-5-oxo-L-norleucine = CoA + N-acetyl-6-diazo-5-oxo-L-norleucine | acetyl-CoA:6-diazo-5-oxo-L-norleucine Nalpha-acetyltransferase | None | azpI (gene name) | |
| 2.3.3.21 | (R)-citramalate synthase | False | 15 | 13570 | 0 | 8 | acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate | None | None | CimA | |
| 2.4.1.385 | sterol 27-beta-glucosyltransferase | True | 0 | 0 | 0 | 1 | UDP-alpha-D-glucose + a 27-hydroxysteroid = UDP + a sterol 27-beta-D-glucoside | UDP-alpha-D-glucose:sterol 27-O-beta-D-glucosyltransferase | None | None | |
| 2.4.1.386 | GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting) | True | 0 | 0 | 0 | 3 | UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R = UDP + beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide 6-beta-N-acetylglucosaminyltransferase (configuration-inverting) | None | UDP-GlcNAc:GlcNAcbeta1-3Gal(-R) beta1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase; dIGnT; C2GnT2 (misleading) | |
| 2.6.1.120 | beta-alanine---2-oxoglutarate transaminase | True | 0 | 0 | 0 | 4 | beta-alanine + 2-oxoglutarate = 3-oxopropanoate + L-glutamate | beta-alanine:2-oxoglutarate aminotransferase | None | pydD (gene name); beta-alanine aminotransferase | |
| 2.6.1.121 | 8-amino-7-oxononanoate carboxylating dehydrogenase | False | 2 | 529 | 0 | 1 | (8S)-8-amino-7-oxononanoate + [protein]-L-lysine + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + [protein]-(S)-2-amino-6-oxohexanoate (overall reaction);;(1a) (8S)-8-amino-7-oxononanoate + [protein]-L-lysine + NAD(P)H + H+ = [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + H2O + NAD(P)+;;(1b) [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + CO2 + H2O + NAD(P)+ = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + [protein]-(S)-2-amino-6-oxohexanoate + NAD(P)H + H+ | (8S)-8-amino-7-oxononanoate:[protein]-L-lysine aminotransferase (N-carboxylating) | None | bioU (gene name) | |
| 2.6.1.122 | UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase | False | 1 | 0 | 0 | 1 | UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate | UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase | None | gnnB (gene name) | |
| 2.6.1.123 | 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) | False | 0 | 1 | 0 | 2 | chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + NH3 (overall reaction);;(1a) 2 L-glutamine + 2 H2O = 2 L-glutamate + 2 NH3;;(1b) chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O;;(1c) (2S)-2-amino-4-deoxychorismate + NH3 = 4-amino-4-deoxychorismate + NH3 | chorismate:L-glutamine aminotransferase (2-amino-4-deoxychorismate-forming) | None | ADCS (ambiguous); ADC synthase (ambiguous); pabAB (gene names) | |
| 2.7.1.234 | D-tagatose-1-phosphate kinase | True | 0 | 0 | 0 | 2 | ATP + D-tagatopyranose 1-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate | ATP:D-tagatopyranse-1-phosphate 6-phosphotransferase | None | TagK | |
| 2.7.1.235 | lipopolysaccharide core heptose(I) kinase | False | 4 | 0 | 0 | 2 | ATP + an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] | ATP:an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 4-O-phosphotransferase | None | WaaP; RfaP | |
| 2.7.7.107 | (2-aminoethyl)phosphonate cytidylyltransferase | False | 2 | 0 | 0 | 2 | CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate | CTP:(2-aminoethyl)phosphonate cytidylyltransferase | None | pntC (gene name) | |
| 2.7.10.3 | bacterial tyrosine kinase | True | 0 | 0 | 0 | 11 | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | ATP:[protein]-L-tyrosine O-phosphotransferase (bacterial-type) | None | BY-kinase; bacterial protein tyrosine kinase | |
| 2.8.4.6 | S-methyl-1-thioxylulose 5-phosphate methylthiotransferase | False | 1 | 0 | 0 | 1 | S-methyl-1-thio-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione | S-methyl-1-thio-D-xylulose 5-phosphate:glutathione methylthiotransferase | None | 1-methylthioxylulose 5-phosphate sulfurylase (incorrect) | |
| 3.1.7.13 | neryl diphosphate diphosphatase | False | 1 | 0 | 0 | 1 | neryl diphosphate + H2O = nerol + diphosphate | neryl-diphosphate diphosphohydrolase | None | NES (gene name); nerol synthase | |
| 3.2.1.215 | arabinogalactan exo alpha-(1,3)-alpha-D-galactosyl-(1->3)-L-arabinofuranosidase (non-reducing end) | True | 0 | 0 | 0 | 1 | Hydrolysis of alpha-D-Galp-(1->3)-L-Araf disaccharides from non-reducing terminals in branches of type II arabinogalactan attached to proteins. | type II arabinogalactan exo alpha-(1,3)-[alpha-D-galactosyl-(1->3)-L-arabinofuranose] hydrolase (non-reducing end) | None | 3-O-alpha-D-galactosyl-alpha-L-arabinofuranosidase | |
| 3.4.17.25 | glutathione-S-conjugate glycine hydrolase | True | 0 | 0 | 0 | 0 | a glutathione-S-conjugate + H2O = a [gamma-glutamyl-L-cysteine]-S-conjugate + glycine | glutathione-S-conjugate glycine hydrolase | None | PCS1 (gene name); PRC1 (gene name); CPC (gene name); ATG42 (gene name); alr0975 (locus name) | |
| 3.5.1.137 | N-methylcarbamate hydrolase | True | 0 | 0 | 0 | 14 | an N-methyl carbamate ester + H2O = an alcohol + methylamine + CO2 | N-methyl carbamate ester hydrolase | None | mcbA (gene name); cehA (gene name); cfdJ (gene name); carbaryl hydrolase; carbofuran hydrolase | |
| 4.2.1.178 | difructose-dianhydride-III synthase | True | 0 | 0 | 0 | 4 | inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O | inulobiose hydro-lyase (alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride-forming) | None | DFA-IIIase; difructose anhydride III hydrolase | |
| 4.2.1.179 | difructose-anhydride-I synthase | True | 0 | 0 | 0 | 2 | inulobiose = bis-D-fructose 2',1:2,1'-dianhydride + H2O | inulobiose hydro-lyase (alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,1'-dianhydride-forming) | None | DFAIase; inulobiose hydrolase; bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase | |
| 4.3.99.5 | nitrosuccinate lyase | False | 2 | 0 | 0 | 2 | 2-nitrobutanedioate = fumarate + nitrite | 2-nitrobutanedioate lyase (fumarate-forming) | None | creD (gene name) | |
| 4.8.1.1 | L-piperazate synthase | True | 0 | 0 | 0 | 2 | N5-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H2O | (3S)-1,2-diazinane-3-carboxylate hydrolase (N5-hydroxy-L-ornithine-forming) | None | ktzT (gene name) | |
| 4.8.1.2 | aliphatic aldoxime dehydratase | False | 4 | 2 | 0 | 6 | an aliphatic aldoxime = an aliphatic nitrile + H2O | aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) | None | OxdA; aliphatic aldoxime hydro-lyase | |
| 4.8.1.3 | indoleacetaldoxime dehydratase | False | 1 | 0 | 0 | 7 | (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O | (indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming] | None | indoleacetaldoxime hydro-lyase; 3-indoleacetaldoxime hydro-lyase; indole-3-acetaldoxime hydro-lyase; indole-3-acetaldehyde-oxime hydro-lyase; (indol-3-yl)acetaldehyde-oxime hydro-lyase | |
| 4.8.1.4 | phenylacetaldoxime dehydratase | False | 1 | 0 | 0 | 5 | (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O | (Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) | None | PAOx dehydratase; arylacetaldoxime dehydratase; OxdB; (Z)-phenylacetaldehyde-oxime hydro-lyase | |
| 4.98.1.1 | protoporphyrin ferrochelatase | False | 357 | 25118 | 0 | 49 | protoheme + 2 H+ = protoporphyrin + Fe2+ | protoheme ferro-lyase (protoporphyrin-forming) | None | ferro-protoporphyrin chelatase; iron chelatase (ambiguous); heme synthetase (ambiguous); heme synthase (ambiguous); protoheme ferro-lyase; ferrochelatase (ambiguous) | |
| 5.3.99.12 | lachrymatory-factor synthase | False | 1 | 0 | 0 | 3 | (E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide | (E)-alk-1-en-1-SO-peroxol isomerase [(Z)-alkanethial S-oxide-forming] | None | LFS | |
| 5.6.2.3 | DNA 5'-3' helicase | False | 114 | 17030 | 3 | 32 | Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand. | DNA 5'-3' helicase (ATP-hydrolysing) | None | DnaB helicase; replication fork helicase; 5' to 3' DNA helicase; BACH1 helicase; BcMCM; BLM protein; BRCA1-associated C-terminal helicase; CeWRN-1; Dbp9p; DNA helicase A; DNA helicase E; DNA helicase II; DNA helicase III; DNA helicase VI; dnaB (gene name); DnaB helicase E1; helicase HDH IV; Hel E; helicase DnaB; helicase domain of bacteriophage T7 gene 4 protein helicase; PcrA helicase; hHcsA; Hmi1p; hPif1; MCM helicase; MCM protein; MPH1; PcrA; PfDH A; Pfh1p; PIF1; replicative DNA helicase | |
| 5.6.2.4 | DNA 3'-5' helicase | False | 316 | 197945 | 0 | 26 | Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction. | DNA 3'-5' helicase (ATP-hydrolysing) | None | uvrD (gene name); rep (gene name); RECQ (gene name); MER3 (gene name); Holliday junction DNA helicase | |
| 6.3.2.61 | tubulin-glutamate ligase | True | 0 | 0 | 0 | 7 | n ATP + [tubulin]-L-glutamate + n L-glutamate = [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate (overall reaction);;(1a) ATP + [tubulin]-L-glutamate + L-glutamate = [tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate;; (1b) ATP + [tubulin]-(gamma-L-glutamyl)-L-glutamate + L-glutamate = [tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + ADP + phosphate;; (1c) ATP + [tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate = [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate | [tubulin]-L-glutamate:L-glutamate ligase (ADP-forming) | None | alpha-tubulin-glutamate ligase; tubulin polyglutamylase; TTLL1 (ambiguous); TTLL5 (ambiguous); TTLL6 (ambiguous) | |
| 6.3.2.62 | beta-tubulin-glutamate ligase | True | 0 | 0 | 0 | 4 | n ATP + [beta-tubulin]-L-glutamate + n L-glutamate = [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate (overall reaction);;(1a) ATP + [beta-tubulin]-L-glutamate + L-glutamate = [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate;;(1b) ATP + [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + L-glutamate = [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + ADP + phosphate;;(1c) ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate = [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate | [beta-tubulin]-L-glutamate:L-glutamate ligase (ADP-forming) | None | beta-tubulin polyglutamylase; TTLL4 (ambiguous); TTLL7 (ambiguous) | |
| 6.7.1.1 | 3-amino-2-hydroxy-4-methoxybenzoate diazotase | False | 1 | 0 | 0 | 1 | ATP + 3-amino-2-hydroxy-4-methoxybenzoate + nitrite = AMP + diphosphate + cremeomycin + H2O | 3-amino-2-hydroxy-4-methoxybenzoate:nitrite ligase (AMP-forming) | None | creM (gene name) | |
| 1.1.1.427 | D-arabinose 1-dehydrogenase (NADP+) | False | 1 | 0 | 0 | 0 | D-arabinofuranose + NADP+ = D-arabinono-1,4-lactone + NADPH + H+ | D-arabinose:NADP+ 1-oxidoreductase | None | AraDH; adh-4 (gene name) | |
| 1.1.1.428 | 4-methylthio 2-oxobutanoate reductase (NADH) | True | 0 | 0 | 0 | 0 | (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+ = 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ | (2R)-2-hydroxy-4-(methylsulfanyl)butanoate:NAD+ 2-oxidoreductase | None | CTBP1 (gene name); C-terminal-binding protein 1; MTOB reductase; 4-methylthio 2-oxobutyrate reductase; 4-methylthio 2-oxobutyric acid reductase | |
| 1.1.1.429 | (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase | False | 1 | 0 | 0 | 0 | (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD+ = (S)-2-benzoylsuccinyl-CoA + NADH + H+ | (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA:NAD+ oxidoreductase | None | bbsCD (gene name) | |
| 1.3.3.17 | benzylmalonyl-CoA dehydrogenase | False | 1 | 0 | 0 | 0 | benzylmalonyl-CoA + O2 = (E)-cinnamoyl-CoA + CO2 + H2O2 | benzylmalonyl-CoA:oxygen oxidoreductase (decarboxylating) | None | iaaF (gene name) | |
| 1.3.99.41 | 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase | False | 2 | 0 | 0 | 0 | 3-(methylsulfanyl)propanoyl-CoA + acceptor = 3-(methylsulfanyl)acryloyl-CoA + reduced acceptor | 3-(methylsulfanyl)propanoyl-CoA:acceptor 2-oxidoreductase | None | dmdC (gene name) | |
| 1.5.3.24 | sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) | False | 16 | 8085 | 0 | 0 | sarcosine + 5,6,7,8-tetrahydrofolate + O2 = glycine + 5,10-methylenetetrahydrofolate + H2O2 | sarcosine, 5,6,7,8-tetrahydrofolate:O2 oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming) | None | TSOX; sarcosine oxidase (ambigious); heterotetrameric sarcosine oxidase | |
| 1.14.14.178 | steroid 22S-hydroxylase | False | 4 | 0 | 0 | 0 | (1) a C27 steroid + O2 + [reduced NADPH---hemoprotein reductase] = a (22S)-22-hydroxy-C27 steroid + 2 H2O + [oxidized NADPH---hemoprotein reductase];;(2) a C28 steroid + O2 + [reduced NADPH---hemoprotein reductase] = a (22S)-22-hydroxy-C28 steroid + 2 H2O + [oxidized NADPH---hemoprotein reductase];;(3) a C29 steroid + O2 + [reduced NADPH---hemoprotein reductase] = a (22S)-22-hydroxy-C29 steroid + 2 H2O + [oxidized NADPH---hemoprotein reductase];; | steroid,NADPH---hemoprotein reductase:oxygen 22S-oxidoreductase (hydroxylating) | None | CYP90B1 (gene name); DWF4 (gene name); steroid C-22 hydroxylase | |
| 1.14.19.79 | 3beta,22alpha-dihydroxysteroid 3-dehydrogenase | False | 2 | 0 | 0 | 0 | (1) (22S)-22-hydroxycampesterol + [reduced NADPH-hemoprotein reductase] + O2 = (22S)-22-hydroxycampest-4-en-3-one + [oxidized NADPH-hemoprotein reductase] + 2 H2O;;(2) 6-deoxoteasterone + [reduced NADPH-hemoprotein reductase] + O2 = 3-dehydro-6-deoxoteasterone + [oxidized NADPH-hemoprotein reductase] + 2 H2O | 3beta,22alpha-dihydroxysteroid,[reduced NADPH-hemoprotein reductase]:oxygen 3-oxidoreductase | None | CYP90A1 (gene name) | |
| 2.3.1.308 | tubulin N-terminal N-acetyltransferase NAT9 | False | 3 | 0 | 0 | 0 | acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] + CoA | acetyl-CoA:N-terminal-Met-[tubulin] Met-Nalpha-acetyltransferase | None | NAT9 (gene name); microtubule-associated N-acetyltransferase NAT9 | |
| 2.4.1.387 | isomaltosyltransferase | False | 1 | 0 | 0 | 0 | (1) 2 alpha-isomaltosyl-(1->4)-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-maltotriose + maltotriose;;(2) alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-maltotriose = cyclobis-(1->6)-alpha-nigerosyl + maltotriose | alpha-isomaltosyl-(1->3)-1,4-alpha-D-glucan:1,4-alpha-D-glucan 3-alpha-isomaltosyltransferase | None | None | |
| 2.4.1.388 | glucosylgalactose phosphorylase | True | 0 | 0 | 0 | 0 | beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucopyranose 1-phosphate + D-galactopyranose | beta-D-glucosyl-(1->4)-D-galactose:phosphate alpha-D-glucosyltransferase (configuration-inverting) | None | 4-O-beta-D-glucosyl-D-galactose phosphorylase | |
| 2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase | False | 14 | 2608 | 0 | 0 | CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R | CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting) | None | ST6Gal-I; CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase; lactosylceramide alpha-2,6-N-sialyltransferase; CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase; beta-galactoside alpha-2,6-sialyltransferase | |
| 2.4.3.2 | beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase | False | 12 | 504 | 0 | 0 | CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R = CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R | CMP-N-acetyl-beta-neuraminate:a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R alpha-(2->3)-N-acetylneuraminyltransferase (configuration-inverting) | None | CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1<->1)-ceramide N-acetylneuraminyltransferase (ambiguous); monosialoganglioside sialyltransferase; CMP-N-acetylneuraminate:a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide N-acetyl-beta-neuraminyltransferase | |
| 2.4.3.3 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase | False | 6 | 2351 | 0 | 0 | CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein | CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase | None | None | |
| 2.4.3.4 | beta-galactoside alpha-2,3-sialyltransferase | False | 13 | 2195 | 0 | 0 | CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R | CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2->3)-N-acetylneuraminyl-transferase | None | CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase | |
| 2.4.3.5 | galactosyldiacylglycerol alpha-2,3-sialyltransferase | True | 0 | 0 | 0 | 0 | CMP-N-acetyl-beta-neuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol = CMP + 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol | CMP-N-acetyl-beta-neuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase | None | None | |
| 2.4.3.6 | N-acetyllactosaminide alpha-2,3-sialyltransferase | False | 12 | 0 | 0 | 0 | CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R | CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting) | None | cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase; alpha2->3 sialyltransferase (ambiguous); SiaT (ambiguous); CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase; neolactotetraosylceramide alpha-2,3-sialyltransferase; CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein alpha-(2->3)-N-acetylneuraminyltransferase | |
| 2.4.3.7 | alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase | False | 5 | 1 | 0 | 0 | CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R | CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase | None | sialyltransferase; cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase; SIAT7; ST6GALNAC; (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase; CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase | |
| 2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase | False | 9 | 756 | 0 | 0 | CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R | CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase | None | cytidine monophosphoacetylneuraminate-ganglioside GM3; alpha-2,8-sialyltransferase; ganglioside GD3 synthase; ganglioside GD3 synthetase sialyltransferase; CMP-NeuAc:LM1(alpha2-8) sialyltranferase; GD3 synthase; SAT-2 | |
| 2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase | False | 5 | 1121 | 0 | 0 | CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-N-acetylneuraminyltransferase | None | cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase; CMP-acetylneuraminate-lactosylceramide-sialyltransferase; CMP-acetylneuraminic acid:lactosylceramide sialyltransferase; CMP-sialic acid:lactosylceramide-sialyltransferase; cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase; ganglioside GM3 synthetase; GM3 synthase; GM3 synthetase; SAT 1; CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->3)-N-acetylneuraminyltransferase | |
| 2.4.3.10 | N-acetylglucosaminide alpha-(2,6)-sialyltransferase | True | 0 | 0 | 0 | 0 | CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-R | CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminide N-acetyl-beta-D-glucosamine-6-alpha-N-acetylneuraminyltransferase (configuration-inverting) | None | alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase; N-acetylglucosaminide (alpha 2->6)-sialyltransferase; ST6GlcNAc | |
| 2.7.1.236 | NAD+ 3'-kinase | True | 0 | 0 | 0 | 0 | ATP + NAD+ = ADP + 3'-NADP+ | ATP:NAD+ 3'-phosphotransferase | None | AvrRxo1 | |
| 2.8.3.27 | propanoyl-CoA:succinate CoA transferase | True | 0 | 0 | 0 | 0 | propanoyl-CoA + succinate = propanoate + succinyl-CoA | propanoyl-CoA:succinate CoA transferase | None | succinyl-CoA:propionate CoA-transferase; propionyl-CoA:succinyl-CoA transferase; ASCT; scpC (gene name) | |
| 2.8.3.28 | phenylsuccinyl-CoA transferase | False | 1 | 0 | 0 | 0 | (1) phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate;;(2) phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate | succinyl-CoA:2/3-phenylsuccinate CoA-transferase | None | iaaL (gene name) | |
| 3.2.1.216 | kojibiose hydrolase | True | 0 | 0 | 0 | 0 | kojibiose + H2O = beta-D-glucopyranose + D-glucopyranose | kojibiose glucohydrolase (configuration-inverting) | None | kojibiase | |
| 4.2.1.180 | (E)-benzylidenesuccinyl-CoA hydratase | False | 1 | 0 | 0 | 0 | (R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA = (E)-benzylidenesuccinyl-CoA + H2O | (R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA hydro-lyase | None | bbsH (gene name) | |
| 6.2.1.75 | indoleacetate---CoA ligase | False | 1 | 0 | 0 | 0 | ATP + (indol-3-yl)acetate + CoA = AMP + diphosphate + (indol-3-yl)acetyl-CoA | (indol-3-yl)acetate:CoA ligase (AMP-forming) | None | iaaB (gene name) | |
| 3.2.1.217 | exo-acting protein-alpha-N-acetylgalactosaminidase | True | 0 | 0 | 0 | 0 | a [protein]-N-acetyl-alpha-D-galactosalaminyl-(L-serine/L-threonine) + H2O = a [protein]-(L-serine/L-threonine) + N-acetyl-D-galactosamine | [protein]-N-acetyl-alpha-D-galactosalaminyl-(L-serine/L-threonine) N-acetylgalactosaminohydrolase | None | Nag31 | |
| 1.1.1.430 | D-xylose reductase (NADH) | True | 0 | 0 | 0 | 0 | xylitol + NAD+ = D-xylose + NADH + H+ | xylitol:NAD+ oxidoreductase | None | XYL1 (gene name) (ambiguous) | |
| 1.1.1.431 | D-xylose reductase (NADPH) | True | 0 | 0 | 0 | 0 | xylitol + NADP+ = D-xylose + NADPH + H+ | xylitol:NADP+ oxidoreductase | None | XYL1 (gene name, ambiguous); xyl1 (gene name, ambiguous); xyrA (gene name); xyrB (gene name) | |
| 1.1.1.432 | 6-dehydroglucose reductase | False | 2 | 0 | 0 | 0 | D-glucose + NADP+ = 6-dehydro-D-glucose + NADPH + H+ | D-glucose:NADP+ 6-oxidoreductase | None | D-glucose 6-dehydrogenase; smoB (gene name); squF (gene name) | |
| 1.1.1.433 | sulfoacetaldehyde reductase (NADH) | False | 2 | 0 | 0 | 0 | isethionate + NAD+ = 2-sulfoacetaldehyde + NADH + H+ | isethionate:NAD+ oxidoreductase | None | sarD (gene name); tauF (gene name); sqwF (gene name); BkTauF | |
| 1.1.2.11 | glucoside 3-dehydrogenase (cytochrome c) | True | 0 | 0 | 0 | 0 | a D-glucoside + a ferric c-type cytochrome = a 3-dehydro-D-glucoside + a ferrous c-type cytochrome | a D-glucoside:ferric c-type cytochrome 3-oxidoreductase | None | D-glucoside 3-dehydrogenase (ambiguous); D-aldohexopyranoside dehydrogenase (ambiguous); D-aldohexoside:cytochrome c oxidoreductase; hexopyranoside-cytochrome c oxidoreductase | |
| 1.4.1.28 | secondary-alkyl amine dehydrogenase [NAD(P)+] | False | 1 | 0 | 0 | 0 | a secondary-alkyl amine + H2O + NAD(P)+ = a ketone + NH3 + NAD(P)H + H+ | secondary-alkyl amine:NAD(P)+ oxidoreductase (deaminating) | None | AmDH (ambiguous); amine dehydrogenase (ambiguous) | |
| 1.5.3.25 | fructosyl amine oxidase (glucosone-forming) | True | 0 | 0 | 0 | 0 | an N-(1-deoxy-D-fructos-1-yl)amine + O2 + H2O = D-glucosone + an amine + H2O2 (overall reaction);;(1a) an N-(1-deoxy-D-fructos-1-yl)amine + O2 = a 2-[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexylidene]amine + H2O2;;(1b) a 2-[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexylidene]amine + H2O = D-glucosone + an amine (spontaneous) | N-(1-deoxy-D-fructos-1-yl)amine:oxygen 2-oxidoreductase (glucosone-forming) | None | amadoriase | |
| 1.5.3.26 | fructosyl amine oxidase (fructosamine-forming) | True | 0 | 0 | 0 | 0 | an N-(1-deoxy-D-fructos-1-yl)amine + O2 + H2O = (1-deoxy-D-fructos-1-yl)amine + an aldehyde + H2O2 | N-(1-deoxy-D-fructos-1-yl)amine:oxygen oxidoreductase (fructosamine-forming) | None | None | |
| 1.5.7.3 | N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin) | False | 1 | 0 | 0 | 0 | (1) N,N-dimethylglycine + 2 oxidized ferredoxin + H2O = sarcosine + formaldehyde + 2 reduced ferredoxin + 2 H+;;(2) sarcosine + 2 oxidized ferredoxin + H2O = glycine + formaldehyde + 2 reduced ferredoxin + 2 H+ | N,N-dimethylglycine/sarcosine:ferredoxin oxidoreductase (demethylating) | None | ddhC (gene name); dgcA (gene name) | |
| 1.13.11.93 | 2-oxoadipate dioxygenase/decarboxylase | False | 8 | 8275 | 0 | 0 | 2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2 | 2-oxoadipate dioxygenase/carboxy lyase | None | ydcJ (gene name) | |
| 1.14.11.78 | (R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase | False | 5 | 0 | 0 | 0 | a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2 2-oxoglutarate + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 2 succinate + 3 CO2 + 2 H2O (overall reaction);;(1a) a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2-oxoglutarate + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + succinate + CO2;;(1b) a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + 2-oxoglutarate + O2 = a (3R)-3-isocyanyl-fatty acid + succinate + 2 CO2 + 2 H2O | (3R)-3-[(carboxylmethyl)amino]fatty acid,2-oxoglutarate:oxygen oxidoreductase (isonitrile-forming) | None | scoE (gene name); mmaE (gene name); Rv0097 (locus name) | |
| 1.14.11.79 | protein-L-histidine (3S)-3-hydroxylase | False | 11 | 3 | 0 | 0 | a [protein]-L-histidine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-histidine + succinate + CO2 | protein-L-histidine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating) | None | RIOX1 (gene name); RIOX2 (gene name); protein histidyl hydroxylase | |
| 1.14.13.251 | glycine betaine monooxygenase | False | 6 | 0 | 0 | 0 | glycine betaine + NADH + H+ + O2 = N,N-dimethylglycine + formaldehyde + NAD+ + H2O | glycine betaine,NADH:oxygen oxidoreductase (demethylating) | None | glycine betaine dioxygenase (incorrect); bmoAB (gene names); gbcAB (gene names) | |
| 1.14.14.179 | brassinosteroid 6-oxygenase | False | 3 | 0 | 0 | 0 | 6-deoxocastasterone + 2 O2 + 2 [reduced NADPH---hemoprotein reductase] = castasterone + 3 H2O + 2 [oxidized NADPH---hemoprotein reductase] (overall reaction);;(1a) 6-deoxocastasterone + O2 + [reduced NADPH---hemoprotein reductase] = 6alpha-hydroxy-6-deoxocastasterone + H2O + [oxidized NADPH---hemoprotein reductase];;(1b) 6alpha-hydroxy-6-deoxocastasterone + O2 + [reduced NADPH---hemoprotein reductase] = castasterone + 2 H2O + [oxidized NADPH---hemoprotein reductase] | 6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen 6-oxidoreductase (castasterone-forming) | None | CYP85A1 (gene name); CYP85A2 (gene name); brassinosteroid 6-oxidase | |
| 1.14.14.180 | brassinolide synthase | False | 2 | 0 | 0 | 0 | castasterone + O2 + [reduced NADPH---hemoprotein reductase] = brassinolide + 2 H2O + [oxidized NADPH---hemoprotein reductase] | castasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (lactonizing, brassinolide-forming) | None | CYP85A2 (gene name); CYP85A3 (gene name) | |
| 1.14.14.181 | sulfoquinovose monooxygenase | False | 2 | 0 | 0 | 0 | 6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + sulfite + H2O | 6-sulfo-D-quinovose,FMNH2:oxygen oxidoreductase | None | 6-deoxy-6-sulfo-D-glucose monooxygenase; smoC (gene name); squD (gene name) | |
| 1.14.14.182 | taxoid 7beta-hydroxylase | False | 1 | 0 | 0 | 0 | (1) taxusin + [reduced NADPH---hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH---hemoprotein reductase] + H2O;; (2) 2alpha-hydroxytaxusin + [reduced NADPH---hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH---hemoprotein reductase] + H2O;; | taxusin, [reduced NADPH---hemoprotein reductase]:oxygen 7-oxidoreductase | None | None | |
| 1.14.14.183 | taxoid 2alpha-hydroxylase | True | 0 | 0 | 0 | 0 | (1) taxusin + [reduced NADPH---hemoprotein reductase] + O2 = 2alpha-hydroxytaxusin + [oxidized NADPH---hemoprotein reductase] + H2O;; (2) 7beta-hydroxytaxusin + [reduced NADPH---hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH---hemoprotein reductase] + H2O;; | taxusin, [reduced NADPH---hemoprotein reductase]:oxygen 2-oxidoreductase | None | None | |
| 1.21.3.10 | hercynylcysteine S-oxide synthase | False | 2 | 0 | 0 | 0 | hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | None | Egt1; Egt-1 | |
| 2.1.1.382 | methoxylated aromatic compound---corrinoid protein Co-methyltransferase | True | 0 | 0 | 0 | 0 | a methoxylated aromatic compound + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] = a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + a phenol | methoxylated aromatic compound:cobamide Co-methyltransferase | None | mtoB (gene name); mtvB (gene name); vdmB (gene name) | |
| 2.1.1.384 | [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydromethanopterin methyltransferase | True | 0 | 0 | 0 | 0 | a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydromethanopterin = N5-methyltetrahydromethanopterin + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] | [methylated methoxylated-aromatic-compound-specific corrinoid protein]:tetrahydromethanopterin methyltransferase | None | mtoA (gene name) | |
| 2.1.1.385 | [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase | True | 0 | 0 | 0 | 0 | a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] | [methylated methoxylated-aromatic-compound-specific corrinoid protein]:tetrahydrofolaten methyltransferase | None | mtvA (gene name) | |
| 2.2.1.15 | 6-deoxy-6-sulfo-D-fructose transketolase | False | 2 | 0 | 0 | 0 | (1) 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate = D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose;;(2) 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate = D-xylulose-5-phosphate + sulfoacetaldehyde | 6-deoxy-6-sulfo-D-fructose:D-glyceraldehyde-3-phosphate glycolaldehydetransferase | None | 6-deoxy-6-sulfo-erythrulose transketolase; sqwGH (gene name) | |
| 2.4.1.389 | solabiose phosphorylase | False | 1 | 0 | 0 | 0 | solabiose + phosphate = D-galactose + alpha-D-glucose 1-phosphate | solabiose:phosphate alpha-D-glucosyltransferase | None | None | |
| 2.4.99.23 | lipopolysaccharide heptosyltransferase I | False | 5 | 6889 | 0 | 0 | ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] | ADP-L-glycero-beta-D-manno-heptose:an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] 5-alpha-heptosyltransferase | None | HepI; rfaC (gene name); WaaC; heptosyltransferase I (ambiguous) | |
| 2.4.99.24 | lipopolysaccharide heptosyltransferase II | False | 6 | 10813 | 0 | 0 | ADP-L-glycero-beta-D-manno-heptose + an alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] | ADP-L-glycero-beta-D-manno-heptose:an alpha-L-glycero-D-manno-heptosyl-(1->5)-[alpha-Kdo-(2->4)]-alpha -Kdo-(2->6)-[lipid A] 3-alpha-heptosyltransferase | None | HepII; rfaF (gene name); WaaF; heptosyltransferase II | |
| 2.4.99.25 | lipopolysaccharide heptosyltransferase III | False | 2 | 0 | 0 | 0 | ADP-L-glycero-beta-D-manno-heptose + an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->7)-alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] | ADP-L-glycero-beta-D-manno-heptose:an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 7-alpha-heptosyltransferase | None | waaQ (gene name); rfaQ (gene name) | |
| 2.5.1.155 | phosphoglycerol geranylfarnesyltransferase | True | 0 | 0 | 0 | 0 | all-trans-pentaprenyl diphosphate + sn-glycerol 1-phosphate = sn-3-O-(farnesylgeranyl)glycerol 1-phosphate + diphosphate | all-trans pentaprenyl diphosphate:sn-glycerol-1-phosphate pentaprenyltransferase | None | GFGP synthase | |
| 2.5.1.156 | geranylfarnesylglycerol-phosphate geranylfarnesyltransferase | True | 0 | 0 | 0 | 0 | all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate | all-trans-pentaprenyl diphosphate:sn-3-O-(pentaprenyl)glycerol 1-phosphate pentaprenyltransferase | None | DGFGP synthase; 2,3-bis-O-(farnesylgeranyl)-sn-glycerol 1-phosphate synthase; 2,3-di-O-farnesylgeranylglyceryl synthase | |
| 2.6.1.124 | [amino-group carrier protein]-gamma-(L-ornithyl)-L-glutamate aminotransferase | False | 9 | 823 | 0 | 0 | an [amino-group carrier protein]-C-terminal-[gamma-(L-ornithyl)-L-glutamate] + 2-oxoglutarate = an [amino-group carrier protein]-C-terminal-[gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate] + L-glutamate | 2-oxoglutarate:[amino-group carrier protein]-C-terminal-[gamma-(L-ornithyl)-L-glutamate] aminotransferase | None | lysJ (gene name) | |
| 2.7.1.237 | GTP-dependent dephospho-CoA kinase | False | 61 | 2468 | 3 | 0 | GTP + 3'-dephospho-CoA = GDP + CoA | GTP:3'-dephospho-CoA 3'-phosphotransferase | None | None | |
| 2.7.1.238 | phenol phosphorylase | True | 0 | 0 | 0 | 0 | ATP + phenol + H2O = AMP + phenyl phosphate + phosphate | ATP:phenol phosphotransferase (AMP-forming) | None | phenylphosphate synthase | |
| 2.7.2.19 | [amino-group carrier protein]-L-glutamate 6-kinase | False | 23 | 989 | 0 | 0 | ATP + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate = ADP + an [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate | [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamine 5-O-kinase | None | lysZ (gene name) | |
| 2.7.11.34 | NEK6-subfamily protein kinase | False | 11 | 2509 | 1 | 0 | ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | None | None | NEK6; NEK7; nekl-3 | |
| 3.4.21.122 | transmembrane protease serine 2 | False | 2 | 0 | 16 | 0 | The enzyme cleaves angiotensin-converting enzyme 2 (EC 3.4.17.23) and cleaves influenzea A and B virus and coronavirus spike glycoproteins at arginine residues. | None | None | TMPRSS2 (gene name); epitheliasin | |
| 3.13.2.1 | adenosylhomocysteinase | False | 244 | 35006 | 1 | 0 | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | S-adenosyl-L-homocysteine hydrolase | None | S-adenosylhomocysteine synthase; S-adenosylhomocysteine hydrolase (ambiguous); adenosylhomocysteine hydrolase; S-adenosylhomocysteinase; SAHase; AdoHcyase | |
| 3.13.2.3 | (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming) | False | 6 | 1 | 0 | 0 | (R)-S-adenosyl-L-methionine + H2O = adenosine + L-methionine | (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming) | None | SAM hydroxide adenosyltransferase | |
| 4.1.1.122 | L-cysteate decarboxylase | True | 0 | 0 | 0 | 0 | L-cysteate = taurine + CO2 | L-cysteate carboxy-lyase (taurine-forming) | None | CAD | |
| 4.1.1.123 | phenyl-phosphate phosphatase/carboxylase | True | 0 | 0 | 0 | 0 | 4-hydroxybenzoate + phosphate = phenyl phosphate + CO2 + H2O | 4-hydroxybenzoate carboxy-lyase (phenyl phosphate-forming) | None | phenyl phosphate carboxylase | |
| 4.6.1.26 | uridylate cyclase | False | 9 | 0 | 1 | 0 | UTP = 3',5'-cyclic UMP + diphosphate | UTP diphosphate-lyase (cyclizing; 3',5'-cyclic-UMP-forming) | None | pycC (gene name) (ambiguous) | |
| 5.3.1.37 | 4-deoxy-4-sulfo-D-erythrose isomerase | False | 1 | 0 | 0 | 0 | 4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose | 4-deoxy-4-sulfo-D-erythrose ketose-aldose isomerase | None | sqwI (gene name) | |
| 7.1.1.12 | succinate dehydrogenase (electrogenic, proton-motive force generating) | True | 0 | 0 | 0 | 0 | succinate + menaquinone + 2 H+[side 1] = fumarate + menaquinol + 2 H+[side 2] | succinate:quinone oxidoreductase (electrogenic, proton-motive force generating) | None | None | |
| 1.1.3.50 | C-glycoside oxidase | True | 0 | 0 | 0 | 0 | carminate + O2 = 3'-dehydrocarminate + H2O2 | carminate:oxygen 3'-oxidoreductase (H2O2-forming) | None | carA (gene name) | |
| 2.3.1.309 | [beta-tubulin]-L-lysine N-acetyltransferase | True | 0 | 0 | 0 | 0 | acetyl-CoA + a [beta-tubulin]-L-lysine = CoA + a [beta-tubulin]-N6-acetyl-L-lysine | acetyl-CoA:[beta-tubulin]-L-lysine N6-acetyltransferase | None | San; NatE; NAA50 (gene name) | |
| 2.3.1.310 | benzoylsuccinyl-CoA thiolase | True | 0 | 0 | 0 | 0 | (S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA | (S)-2-benzoylsuccinyl-CoA:CoA benzoyltransferase (benzoyl-CoA-forming) | None | bbsAB (gene names) | |
| 2.7.7.108 | protein adenylyltransferase | False | 307 | 37023 | 0 | 0 | (1) ATP + a [protein]-L-serine = diphosphate + a [protein]-O-(5'-adenylyl)-L-serine;;(1) ATP + a [protein]-L-threonine = diphosphate + a [protein]-O-(5'-adenylyl)-L-threonine;;(1) ATP + a [protein]-L-tyrosine = diphosphate + a [protein]-O-(5'-adenylyl)-L-tyrosine | [protein] L-serine/L-threonine/L-tyrosine adenylyltransferase | None | AMPylase; selO (gene name); FMP40 (gene name); SELENOO (gene name); IbpA; VopS; DrrA; FICD (gene name) | |
| 3.6.1.75 | diacylglycerol diphosphate phosphatase | False | 17 | 940 | 0 | 0 | 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate | 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase | None | DGPP phosphatase; DGPP phosphohydrolase; DPP1; DPPL1; DPPL2; PAP2; pyrophosphate phosphatase | |
| 4.3.2.11 | (3R)-3-[(carboxylmethyl)amino]fatty acid synthase | False | 5 | 425 | 0 | 0 | (3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein] = a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O | (3R)-3-[(carboxylmethyl)amino]fatty acid glycine-lyase ((2E)-unsaturated fatty acyl-[acyl-carrier protein]-forming) | None | scoD (gene name); mmaD (gene name) | |
| 6.2.1.76 | malonate---CoA ligase | False | 5 | 0 | 0 | 0 | ATP + malonate + CoA = AMP + diphosphate + malonyl-CoA | malonate:CoA ligase (AMP-forming) | None | ACSF3 (gene name); AAE13 (gene name); malonyl-CoA synthetase | |
| 1.1.1.434 | 2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase | True | 0 | 0 | 0 | 0 | 2-dehydro-3-deoxy-L-fuconate + NAD+ = 2,4-didehydro-3-deoxy-L-fuconate + NADH + H+ | 2-dehydro-3-deoxy-L-fuconate:NAD+ 4-oxidoreductase | None | None | |
| 1.1.1.435 | L-fucose dehydrogenase | False | 1 | 0 | 0 | 0 | beta-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+ | beta-L-fucopyranose:NADP+ 1-oxidoreductase | None | None | |
| 1.1.1.436 | lactate dehydrogenase (NAD+,ferredoxin) | False | 3 | 0 | 0 | 0 | lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster | lactate:NAD+,ferredoxin oxidoreductase | None | electron bifurcating LDH/Etf complex | |
| 1.1.1.437 | 5-dehydrofumagillol 5-reductase | False | 1 | 0 | 0 | 0 | fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+ | fumagillol:NADP+ 5-oxidoreductase | None | af490 (gene name); Fma-KR | |
| 1.3.1.125 | acrylate reductase | False | 1 | 0 | 0 | 0 | propanoate + NAD+ = acrylate + NADH + H+ | propanoate:NAD+ oxidoreductase | None | ard (gene name); NADH:acrylate oxidoreductase | |
| 1.3.2.4 | fumarate reductase (cytochrome) | False | 3 | 143 | 0 | 0 | succinate + 2 ferricytochrome c = fumarate + 2 ferrocytochrome c | succinate:ferricytochrome-c oxidoreductase | None | fccA (gene name); fcc3 (gene name); flavocytochrome c3 | |
| 1.4.2.2 | nicotine dehydrogenase | False | 1 | 0 | 0 | 0 | (S)-nicotine + 2 ferricytochrome c = N-methylmyosmine + 2 ferrocytochrome c + 2 H+ | (S)-nicotine:cytochrome c oxidoreductase (N-methylmimosine-forming) | None | nicA2 (gene name) | |
| 1.4.2.3 | pseudooxynicotine dehydrogenase | False | 2 | 0 | 0 | 0 | pseudooxynicotine + H2O + 2 ferricytochrome c = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + 2 ferrocytochrome c + 2 H+ | 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:c-type cytochrome oxidoreductase (methylamine releasing) | None | pnaO (gene name) | |
| 1.4.3.27 | homospermidine oxidase | True | 0 | 0 | 0 | 0 | sym-homospermidine + 2 O2 + H2O = 1-formylpyrrolizidine + 2 H2O2 + 2 NH3 (overall reaction);;(1a) sym-homospermidine + O2 = N-(4-aminobutylpyrrolinium) ion + H2O2 + NH3;;(1b) N-(4-aminobutylpyrrolinium) ion + O2 + H2O = N-(4-oxobutylpyrrolinium) ion + NH3 + H2O2;;(1c) N-(4-oxobutylpyrrolinium) ion = 1-formylpyrrolizidine (spontaneous) | homospermidine:oxygen oxidase (deaminating, cyclizing) | None | HSO | |
| 1.14.11.80 | methylcytosine dioxygenase | False | 11 | 3512 | 1 | 0 | (1) 5-methylcytosine in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine in DNA + succinate + CO2;;(2) 5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2 = 5-formylcytosine in DNA + succinate + CO2 + H2O;;(3) 5-formylcytosine in DNA + 2-oxoglutarate + O2 = 5-carboxycytosine in DNA + succinate + CO2 | 5-methylcytosine in DNA,2-oxoglutarate:oxygen oxidoreductase | None | TET1 (gene name); TET2 (gene name); TET3 (gene name) | |
| 1.14.11.81 | (-)-cyclopenine synthase | False | 1 | 0 | 0 | 0 | (1) cyclopeptine + 2-oxoglutarate + O2 = dehydrocyclopeptine + succinate + CO2 + H2O;;(2) dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + succinate + CO2 | cyclopeptine,2-oxoglutarate:oxygen oxidoreductase ((-)-cyclopenine-forming) | None | asqJ (gene name) | |
| 1.14.11.82 | 5-dehydro-6-demethoxyfumagillol dioxygenase | False | 1 | 0 | 0 | 0 | 5-dehydro-6-demethoxyfumagillol + 2-oxoglutarate + O2 = 5-dehydro-6-demethoxy-6-hydroxyfumagillol + succinate + CO2 | 5-dehydro-6-demethoxyfumagillol,2-oxoglutarate:oxygen oxidoreductase (6-hydroxylating) | None | fmaF (gene name); Fma-C6H | |
| 1.14.14.184 | 5-dehydro-6-demethoxyfumagillol synthase | False | 1 | 0 | 0 | 0 | (+)-exo-beta-bergamotene + 2 [reduced NADPH---hemoprotein reductase] + 3 O2 = 5-dehydro-6-demethoxyfumagillol + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction);;(1a) (+)-exo-beta-bergamotene + [reduced NADPH---hemoprotein reductase] + O2 = (5R)-hydroxy-(+)-exo-beta-bergamotene + [oxidized NADPH---hemoprotein reductase] + H2O;;(1b) (5R)-hydroxy-(+)-exo-beta-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O;;(1c) (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + [reduced NADPH---hemoprotein reductase] + O2 = 5-dehydro-6-demethoxyfumagillol + [oxidized NADPH---hemoprotein reductase] + H2O | (+)-exo-beta-bergamotene,[reduced NADPH---hemoprotein reductase] oxidoreductase (5-dehydro-6-demethoxyfumagillol-producing) | None | fumagillin multifunctional cytochrome P450 monooxygenase; Fma-P450; fmaG (gene name) | |
| 1.21.98.5 | tetraether lipid synthase | True | 0 | 0 | 0 | 0 | (1) 2 a 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor;;(2) a 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 2 S-adenosyl-L-methionine + reduced acceptor = a macrocyclic archaeol phospholipid + 2 L-methionine + 2 5'-deoxyadenosine + acceptor | a 2,3-bis-O-phytanyl-sn-glycero-phospholipid:S-adenosyl-L-methionine,acceptor oxidoreductase (cyclyzing) | None | GDGT/MA synthase; GDGT/MAS; tetraether synthase; Tes; Mj0619 (locus name) | |
| 2.1.1.386 | small RNA 2'-O-methyltransferase | False | 13 | 5550 | 0 | 0 | S-adenosyl-L-methionine + an [sRNA]-3'-end ribonucleotide = S-adenosyl-L-homocysteine + an [sRNA]-3'-end 2'-O-methylated ribonucleotide | S-adenosyl-L-methionine:[sRNA]-3'-end ribonucleotide 2'-O-methyltransferase | None | HENMT1 (gene name); HEN1 (gene name) | |
| 2.1.1.387 | 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase | False | 1 | 0 | 0 | 0 | S-adenosyl-L-methionine + 5-dehydro-6-demethoxy-6-hydroxyfumagillol = S-adenosyl-L-homocysteine + 5-dehydrofumagillol | S-adenosyl-L-methionine:5-dehydro-6-demethoxy-6-hydroxyfumagillol 6-O-methyltransferase | None | Fma-MT; fmaD (gene name); af390-400 (gene name) | |
| 2.3.1.311 | tRNA carboxymethyluridine synthase | False | 18 | 4374 | 0 | 0 | acetyl-CoA + uridine34 in tRNA + S-adenosyl-L-methionine + H2O = CoA + 5-(carboxymethyl)uridine34 in tRNA + L-methionine + 5'-deoxyadenosine | acetyl-CoA:tRNA uridine carboxymethyltransferase | None | elongator complex; ELP3 | |
| 2.4.1.390 | 4,3-alpha-glucanotransferase | True | 0 | 0 | 0 | 0 | formation of a mixed (1->4)/(1->3)-alpha-D-glucan from (1->4)-alpha-D-glucans | (1->4)-alpha-D-glucan:(1->4)/(1->3)-alpha-D-glucan 3-alpha-D-glucosyltransferase | None | gtfB (gene name) (ambiguous) | |
| 2.4.1.391 | beta-1,2-glucosyltransferase | True | 0 | 0 | 0 | 0 | [(1->2)-beta-D-glucosyl]n + a D-glucoside = [(1->2)-beta-D-glucosyl]n-1 + a beta-D-glucosyl-(1->2)-D-glucoside | 1,2-beta-D-glucan:D-glucoside 2-beta-D-glucosyltransferase (configuration-retaining) | None | None | |
| 2.4.1.392 | 3-O-beta-D-glucopyranosyl-beta-D-glucuronide phosphorylase | True | 0 | 0 | 0 | 0 | a 3-O-beta-D-glucosyl-beta-D-glucuronoside + phosphate = a beta-D-glucuronoside + alpha-D-glucopyranose 1-phosphate | 3-O-beta-D-glucopyranosyl-beta-D-glucuronide:phosphate alpha-D-glucosyltransferase | None | PBOR_13355 (locus name) | |
| 2.7.1.239 | alpha-D-ribose-1-phosphate 5-kinase (ATP) | False | 1 | 0 | 0 | 0 | ATP + alpha-D-ribose-1-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate | ATP:alpha-D-ribose-1-phosphate 5-phosphotransferase | None | None | |
| 2.7.8.48 | ceramide phosphoethanolamine synthase | False | 1 | 0 | 0 | 0 | CDP-ethanolamine + a ceramide = a ceramide phosphorylethanolamine + CMP | CDP-ethanolamine:ceramide phosphoethanolaminyltransferase | None | Cpes (gene name); CPE synthase | |
| 3.1.1.120 | L-fucono-1,5-lactonase | False | 3 | 0 | 0 | 0 | L-fucono-1,5-lactone + H2O = L-fuconate | L-fucono-1,5-lactone lactonohydrolase | None | None | |
| 3.1.3.109 | ribulose-1,5-bisphosphate 5-phosphatase | False | 1 | 0 | 0 | 0 | D-ribulose-1,5-bisphosphate + H2O = D-ribulose 1-phosphate + phosphate | D-ribulose-1,5-bisphosphate 5-phosphohydrolase | None | RuBP 5-phosphatase | |
| 3.2.1.218 | alpha-3'-ketoglucosidase | True | 0 | 0 | 0 | 0 | 3'-dehydrosucrose + H2O = 3-dehydro-D-glucopyranose + D-fructofuranose | 3'-dehydrosucrose 3'-dehydroglucohydrolase | None | 3'-keto-alpha-D-gluco-disaccharide hydrolase; alpha-3-ketoglucosidase (incorrect); 3-keto-glucoside hydrolase | |
| 3.2.1.219 | palatinase | True | 0 | 0 | 0 | 0 | palatinose + H2O = alpha-D-glucopyranose + D-fructofuranose | palatinose alpha-1,6-glucohydrolase | None | palQ (gene name) | |
| 3.6.1.76 | prenyl-diphosphate phosphatase | False | 1 | 0 | 0 | 0 | (1) prenyl diphosphate + H2O = prenyl phosphate + phosphate;;(2) 3-methylbut-3-en-1-yl diphosphate + H2O = 3-methylbut-3-en-1-yl phosphate + phosphate | prenyl diphosphate/3-methylbut-3-en-1-yl diphosphate phosphohydrolase | None | None | |
| 4.1.99.27 | cyclopenase | False | 1 | 0 | 0 | 0 | (-)-cyclopenine = viridicatin + methyl isocyanate | (-)-cyclopenine methyl-isocyanate lyase (viridicatin-forming) | None | asqI (gene name) | |
| 4.2.2.28 | alpha-L-rhamnosyl-(1->4)-D-glucuronate lyase | False | 0 | 0 | 1 | 0 | alpha-L-rhamnosyl-(1->4)-D-glucuronate = L-rhamnopyranose + 4-deoxy-L-threo-hex-4-enopyranuronate | alpha-L-rhamnosyl-(1->4)-D-glucuronate lyase | None | L-rhamnose-alpha-1,4-D-glucuronate lyase; FoRham (gene name) | |
| 4.2.3.206 | (-)-cyatha-3,12-diene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate | geranylgeranyl diphosphate-lyase [(-)-cyatha-3,12-diene-forming] | None | eriG (gene name); CyaTC | |
| 4.2.3.207 | neoverrucosan-5beta-ol synthase | True | 0 | 0 | 0 | 0 | geranylgeranyl diphosphate + H2O = neoverrucosan-5beta-ol + diphosphate | geranylgeranyl- diphosphate diphosphate-lyase (neoverrucosan-5beta-ol-forming) | None | SapTC1 | |
| 4.2.3.208 | verrucosan-2beta-ol synthase | True | 0 | 0 | 0 | 0 | geranylgeranyl diphosphate + H2O = verrucosan-2beta-ol + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (verrucosan-2beta-ol-forming) | None | ChlTC2 | |
| 4.2.3.209 | (R)-axinyssene synthase | True | 0 | 0 | 0 | 0 | geranylgeranyl diphosphate = (R)-axinyssene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [(R)-axinyssene-forming] | None | CysTC2 | |
| 4.2.3.210 | lydicene synthase | True | 0 | 0 | 0 | 0 | geranylgeranyl diphosphate = lydicene + diphosphate | geranylgerany-diphosphate diphosphate-lyase (lydicene-forming) | None | StlTC | |
| 4.2.3.211 | (+)-exo-beta-bergamotene synthase | False | 1 | 0 | 0 | 0 | (2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-exo-beta-bergamotene-forming] | None | None | |
| 4.3.3.8 | mimosinase | True | 0 | 0 | 0 | 0 | L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + pyruvate + NH3 (overall reaction);;(1a) L-mimosine = 3-hydroxy-4H-pyrid-4-one + 2-aminoprop-2-enoate;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous) ;;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) | (2S)-2-amino-3-[3-hydroxy-4-oxopyridin-1(4H)-yl]propanoate 3-hydroxy-4H-pyrid-4-one-lyase (2-aminoprop-2-enoate-forming) | None | mimosine amidohydrolase (incorrect) | |
| 4.4.1.42 | S-adenosyl-L-methionine lyase | False | 1 | 6 | 0 | 0 | S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine | S-adenosyl-L-methionine S-methyl-5'-thioadenosine-lyase (cyclizing; L-homoserine lactone-forming) | None | T3p01 (gene name); SAM lyase; SAMase; adenosylmethionine cyclotransferase; S-adenosyl-L-methionine alkyltransferase (cyclizing) | |
| 4.4.1.43 | canavanine-gamma-lyase | False | 2 | 0 | 0 | 0 | L-canavanine + H2O = L-homoserine + N-hydroxyguanidine (overall reaction);;(1a) L-canavanine = vinylglycine + N-hydroxyguanidine;;(1b) vinylglycine = (2E)-2-aminobut-2-enoate (spontaneous);;(1c) (2E)-2-aminobut-2-enoate + H2O = L-homoserine (spontaneous) | L-canavanine N-hydroxyguanidine-lyase (L-homoserine-forming) | None | CangL | |
| 4.8.1.5 | thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming) | False | 6 | 79 | 0 | 0 | an N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur | thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming) | None | NSP (gene name); nitrile-specifier protein | |
| 4.8.1.6 | N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming) | False | 1 | 0 | 0 | 0 | N-(sulfonatooxy)alkenimidothioic acid with a terminal double bond = an epithionitrile + sulfate | N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming) | None | ESP (gene name); epithionitrile-specifier protein; epithiospecifier protein | |
| 4.8.1.7 | phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase | False | 1 | 0 | 0 | 0 | phenyl-N-(sulfonatooxy)methanimidothioate = benzylthiocyanate + sulfate | phenyl-N-(sulfonatooxy)methanimidothioate sulfate-lyase (benzylthiocyanate-forming) | None | TFP (gene name) (ambiguous); thiocyanate-forming protein (ambiguous) | |
| 4.8.1.8 | N-(sulfonatooxy)prop-2-enimidothioate sulfolyase | False | 2 | 0 | 0 | 0 | (1) N-(sulfonatooxy)prop-2-enimidothioate = prop-2-enylthiocyanate + sulfate;;(2) N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate | N-(sulfonatooxy)prop-2-enimidothioate sulfate-lyase (prop2-enylthiocyanate-forming) | None | TFP (gene name) (ambiguous); thiocyanate-forming protein (ambiguous) | |
| 5.3.3.24 | neopinone isomerase | True | 0 | 0 | 0 | 0 | neopinone = codeinone | neopinone Delta8-Delta7-isomerase | None | NISO (gene name) | |
| 7.2.3.1 | Na+-exporting diphosphatase | False | 12 | 9046 | 0 | 0 | diphosphate + H2O + Na+[side 1] = 2 phosphate + Na+[side 2] | diphosphate phosphohydrolase (Na+-transporting) | None | Na+-translocating membrane pyrophosphatase; sodium-translocating pyrophosphatase | |
| 2.1.1.388 | proline betaine---corrinoid protein Co-methyltransferase | True | 0 | 0 | 0 | 0 | L-proline betaine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + N-methyl-L-proline | L-proline betaine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase | None | mtpB (gene name) | |
| 2.1.1.389 | [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase | True | 0 | 0 | 0 | 0 | a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) quaternary-amine-specific corrinoid protein] | [methyl-Co(III) quaternary-amine-specific corrinoid protein]:tetrahydrofolate methyltransferase | None | mtqA (gene name) (ambiguous); [methyl-Co(III) MtqC corrinoid protein]---tetrahydrofolate methyltransferase | |
| 2.1.1.390 | gentamicin X2 methyltransferase | True | 0 | 0 | 0 | 0 | gentamicin X2 + 2 S-adenosyl-L-methionine + reduced acceptor = geneticin + 5'-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + oxidized acceptor (overall reaction);;(1a) S-adenosyl-L-methionine + cob(I)alamin = S-adenosyl-L-homocysteine + methylcob(III)alamin;;(1b) methylcob(III)alamin + gentamicin X2 + S-adenosyl-L-methionine = cob(III)alamin + geneticin + 5'-deoxyadenosine + L-methionine;;(1c) cob(III)alamin + reduced acceptor = cob(I)alamin + oxidized acceptor | S-adenosyl-L-methionine:gentamicin X2 C6'-methyltransferase | None | genK (gene name); gntK (gene name); gentamicin C-methyltransferase (ambiguous) | |
| 2.3.1.312 | D-glutamate N-acetyltransferase | True | 0 | 0 | 0 | 0 | acetyl-CoA + D-glutamate = N-acetyl-D-glutamate + CoA | acetyl-CoA:D-glutamate N-acetyltransferase | None | dgcN (gene name) | |
| 2.3.1.313 | NAD-dependent lipoamidase | True | 0 | 0 | 0 | 0 | [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine + NAD+ + H2O = [lipoyl-carrier protein]-L-lysine + 2''-O-lipoyl-ADP-D-ribose + nicotinamide | [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine:NAD+ lipoyltranferase (NAD+-hydrolysing; 2''-O-lipoyl-ADP-D-ribose-forming) | None | SIRT4; srtN (gene name); cobB (gene name) | |
| 2.3.2.37 | ergosteryl-3beta-O-L-aspartate synthase | True | 0 | 0 | 0 | 0 | L-aspartyl-tRNAAsp + ergosterol = tRNAAsp + 1-(ergostan-3beta-yl)-L-aspartate | L-aspartyl-tRNAAsp:ergosterol-3beta-O-L-aspartyltransferase | None | ErdS | |
| 2.4.1.393 | MMP alpha-(1->4)-mannosyltransferase | True | 0 | 0 | 0 | 0 | GDP-alpha-D-mannose + [3-O-methyl-alpha-D-mannosyl-(1->4)]n-3-O-methyl-alpha-D-mannose = alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)]n-3-O-methyl-alpha-D-mannose + GDP | GDP-alpha-D-mannose:[3-O-methyl-alpha-D-mannosyl-(1->4)]n-3-O-methyl-alpha-D-mannose [(1->4)-alpha-D-mannosyl]transferase | None | manT (gene name) | |
| 2.4.99.26 | O-antigen ligase | True | 0 | 0 | 0 | 0 | a lipid-linked O antigen + a lipid A-core oligosaccharide = a lipopolysaccharide + a polyisoprenyl diphosphate | lipid-linked O-antigen:lipid A-core oligosaccharide O-antigen transferase (configuration-inverting) | None | waaL (gene name); surface polymer:lipid A-core ligase; rfaL (gene name) | |
| 2.4.99.27 | O-antigen polymerase Wzy | True | 0 | 0 | 0 | 0 | n lipid-linked O-antigen repeat units = a lipid-linked O antigen + (n-1) polyisoprenyl diphosphate | lipid-linked O-antigen repeat unit:O-antigen O-antigen repeat-unit transferase | None | wzy (gene name); rfc (gene name); Wzy O-antigen polymerase; Wzy polymerase | |
| 2.5.1.157 | rRNA small subunit aminocarboxypropyltransferase | False | 26 | 4809 | 0 | 0 | S-adenosyl-L-methionine + an N1-methylpseudouridine in rRNA = S-methyl-5'-thioadenosine + an N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA | S-adenosyl-L-methionine:rRNA N1-methylpseudouridine 3-[(3S)-3-amino-3-carboxypropyl]transferase | None | TSR3 (gene name) | |
| 2.7.11.35 | CRIK-subfamily protein kinase | True | 0 | 0 | 0 | 0 | (1) ATP + [protein]-L-serine = ADP + [protein]-O-phospho-L-serine;;(2) ATP + [protein]-L-threonine = ADP + [protein]-O-phospho-L-threonine | None | None | CRIK; CIT; SGK21; Citron; Citron-K; Sticky/Citron Kinase; Citron Rho-Interacting Kinase | |
| 3.1.1.121 | ergosteryl-3beta-O-L-aspartate hydrolase | True | 0 | 0 | 0 | 0 | 1-(ergostan-3beta-yl) L-aspartate + H2O = ergosterol + L-aspartate | ergosteryl-3beta-O-L-aspartate aminoacylesterase | None | ErdH | |
| 3.4.11.27 | archaeal arginyl aminopeptidase | True | 0 | 0 | 0 | 0 | Release of an N-terminal L-arginine from a protein with only minimal activity against other amino acids. L-Arg-7-amido-4-methylcoumarin is the best artificial substrate. | None | None | arginyl aminopeptidase PH1704; PH1704; PfpI peptidase; C56.001 (Merops Identifier) | |
| 3.5.1.138 | lipoamidase | True | 0 | 0 | 0 | 0 | a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine + H2O = a [lipoyl-carrier protein]-L-lysine + (R)-lipoate | [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine amidohydrolase | None | pyruvate dehydrogenase inactivase | |
| 4.1.2.64 | 2-dehydro-3-deoxy-L-fuconate aldolase | True | 0 | 0 | 0 | 0 | 2-dehydro-3-deoxy-L-fuconate = pyruvate + (S)-lactaldehyde | 2-dehydro-3-deoxy-L-fuconate (S)-lactaldehyde-lyase (pyruvate-forming) | None | 2-keto-3-deoxy-L-fuconate aldolase; L-2-keto-3-deoxyfuconate aldolase; fucH (gene name) | |
| 4.1.99.28 | 3'-dehydrocarminate deglycosidase | True | 0 | 0 | 0 | 0 | 3'-dehydrocarminate = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate | 3'-dehydrocarminate lyase (kermesate-forming) | None | carBC (gene names) | |
| 4.2.99.25 | unsaturated pyranuronate lyase | True | 0 | 0 | 0 | 0 | (1) 4-deoxy-L-erythro-hex-4-enopyranuronate = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate;;(2) 4-deoxy-L-threo-hex-4-enopyranuronate = (4S,5R)-4,5-dihydroxy-2,6-dioxohexanoate | 4,5-unsaturated pyranuronate lyase (ring-opening) | None | kdgF (gene name) | |
| 4.3.1.33 | (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase | False | 1 | 0 | 0 | 0 | (1R)-(2-amino-1-hydroxyethyl)phosphonate = phosphonoacetaldehyde + NH3 (overall reaction);;(1a) (1R)-(2-amino-1-hydroxyethyl)phosphonate = (E)-2-aminoethenylphosphonate + H2O;;(1b) (E)-2-aminoethenylphosphonate + H2O = phosphonoacetaldehyde + NH3 | (1R)-(2-amino-1-hydroxyethyl)phosphonate ammonia-lyase | None | pbfA (gene name) | |
| 5.1.1.25 | N-acetyl-D-glutamate racemase | True | 0 | 0 | 0 | 0 | N-acetyl-D-glutamate = N-acetyl-L-glutamate | N-acetyl-glutamate racemase | None | dgcA (gene name) | |
| 7.5.2.14 | ABC-type homopolymeric O-antigen exporter | True | 0 | 0 | 0 | 0 | ATP + a lipid-linked O antigen[cytosol] + H2O = ADP + phosphate + a lipid-linked O antigen[periplasm] | ATP phosphohydrolase (ABC-type, homopolymeric O-antigen exporting) | None | wzm (gene name); wzt (gene name) | |
| 1.3.1.126 | 2-epi-5-epi-valiolone dehydrogenase | True | 0 | 0 | 0 | 0 | 2-epi-5-epi-valiolone + NAD+ = demethylgadusol + NADH + H+ | 2-epi-5-epi-valiolone:NAD+ 2,3-oxidoreductase | None | gadusol synthase | |
| 1.8.1.22 | dissimilatory sulfite reductase system | False | 6 | 0 | 0 | 0 | a [DsrC protein]-trisulfide + NAD+ + 3 H2O = a [DsrC protein]-dithiol + sulfite + NADH + H+ | [DsrC protein]-trisulfide,NAD+ oxidoreductase (sulfite-forming) | None | siroheme sulfite reductase; DsrABL; hydrogen-sulfide:(acceptor) oxidoreductase (incorrect) | |
| 1.8.5.10 | [DsrC]-trisulfide reductase | True | 0 | 0 | 0 | 0 | hydrogen sulfide + a [DsrC protein]-dithiol + 2 quinone = a [DsrC protein]-trisulfide + 2 quinol | hydrogen sulfide:[DsrC protein]-dithiol oxidoreductase (trisulfide-forming) | None | DsrMKJOP complex | |
| 2.1.1.391 | demethylgadusol O-methyltransferase | True | 0 | 0 | 0 | 0 | S-adenosyl-L-methionine + demethylgadusol = S-adenosyl-L-homocysteine + gadusol | S-adenosyl-L-methionine:demethylgadusol 2-O-methyltransferase | None | gadusol synthase; desmethyl gadusol O-methyltransferase | |
| 2.3.3.22 | 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase | True | 0 | 0 | 0 | 0 | an acetyl-[acp] + a 3-oxoacyl-[acp] = a 3-carboxymethyl-3-hydroxy-acyl-[acp] + [acp] | acetyl-[acp]:3-oxoacyl-[acp] C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | None | HMG-CoA synthase-like enzyme; aprE (gene name); curD (gene name); corE (gene name); bryR (gene name); pedP (gene name); 3-carboxymethyl-3-hydroxy-acyl-[acyl-carrier protein] synthase | |
| 2.4.1.395 | reuteransucrase | True | 0 | 0 | 0 | 0 | formation of reuteran from sucrose | sucrose:alpha-D-glucan 4-alpha/6-alpha-D-glucosyltransferase | None | None | |
| 2.4.1.396 | 4,6-alpha-glucanotransferase (linear and branched substrates, branched products) | True | 0 | 0 | 0 | 0 | formation of a branched isomalto/malto-polysaccharide from branched malto-oligosaccharides | branched (1->4)-alpha-D-glucan:(1->4)/(1->6)-alpha-D-glucan 6-alpha-D-glucosyltransferase | None | gtfB (gene name) (ambiguous); gtfD (gene name) | |
| 2.4.99.28 | peptidoglycan glycosyltransferase | False | 320 | 90744 | 0 | 0 | [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate | [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase | None | PG-II; bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase; penicillin binding protein (3 or 1B); peptidoglycan transglycosylase; undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase | |
| 3.1.1.122 | carbendazim hydrolysing esterase | True | 0 | 0 | 0 | 0 | carbendazim + H2O = 2-aminobenzimidazole + CO2 + methanol (overall reaction);;(1a) carbendazim + H2O = N-(1H-1,3-benzodiazol-2-yl)carbamate + methanol;;(1b) N-(1H-1,3-benzodiazol-2-yl)carbamate = 2-aminobenzimidazole + CO2 (spontaneous) | carbendazim methanol hydrolase (decarboxylating) | None | mheI (gene name) | |
| 3.2.1.221 | MMP endo-(1,4)-3-O-methyl-alpha-D-mannosidase | True | 0 | 0 | 0 | 0 | Endohydrolysis of 3-O-methyl-alpha-D-mannosyl-(1->4)-3-O-methyl-D-mannose linkages within (1,4)-3-O-methyl-alpha-D-mannnan substrates | (1,4)-3-O-methyl-alpha-D-mannan 4-alpha-3-O-methyl-D-mannohydrolase | None | MMP alpha-(1->4)-endomannosidase; mmpH (gene name) | |
| 3.2.1.222 | funoran endo-beta-hydrolase | True | 0 | 0 | 0 | 0 | Endohydrolysis of beta-(1->4)-linkages between beta-D-galactopyranose-6-sulfate and 3,6-anhydro-alpha-L-galactopyranose units in funoran | funoran endo beta-(1,4)-glycanohydrolase | None | beta-funoranase | |
| 3.2.1.223 | arabinogalactan exo alpha-(1,3)-beta-L-arabinopyranosyl-(1->3)-L-arabinofuranosidase (non-reducing end) | True | 0 | 0 | 0 | 0 | Hydrolysis of beta-L-Arap-(1->3)-L-Araf disaccharides from non-reducing terminals in branches of type II arabinogalactan attached to proteins. | type II arabinogalactan exo alpha-(1,3)-[beta-L-arabinopyranosyl-(1->3)-L-arabinofuranose] hydrolase (non-reducing end) | None | 3-O-beta-L-arabinopyranosyl-alpha-L-arabinofuranosidase; AAfase | |
| 3.4.21.123 | kumamolysin | True | 0 | 0 | 0 | 0 | The enzyme preferentially hydrolyses peptides having an Ala or Pro residue at P2 position and prefers such charged amino acid residues as Glu or Arg at the P2' position. In the oxidized insulin B chain, kumamolysin preferentially cleaves between Leu15 and Tyr16 | None | None | KSCP; kumamolisin | |
| 3.4.26.1 | intramembrane prenyl-peptidase Rce1 | True | 0 | 0 | 0 | 0 | Hydrolyses the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue | None | None | CaaX prenyl protease 2; prenyl protein-specific endoprotease 2; PPSEP 2; alpha-factor-converting enzyme RCE1; ras converting enzyme; RACE; glutamic-type intramembrane endopeptidase Rce1; type II CAAX protease | |
| 3.4.26.2 | scytalidoglutamic peptidase | True | 0 | 0 | 0 | 0 | Hydrolysis of proteins, with a strong preference for Phe or Tyr at position P1 and one of the smaller amino-acids at P1' in the sequence - P3 - P2 - P1 !P1'- P2'- P3'-. Cleaves the Tyr26-Thr27 bond in the B chain of oxidized insulin, which is not cleaved by pepsin. | None | None | scytalidopepsin-B; SCP-B; SGP; scytalidocarboxylpeptidase-B | |
| 3.8.2.2 | diisopropyl-fluorophosphatase | False | 3 | 0 | 0 | 0 | diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride | diisopropyl-fluorophosphate fluorohydrolase | None | DFPase; tabunase; somanase; organophosphorus acid anhydrolase; organophosphate acid anhydrase; OPA anhydrase (ambiguous); diisopropylphosphofluoridase; dialkylfluorophosphatase; diisopropyl phosphorofluoridate hydrolase; isopropylphosphorofluoridase; diisopropylfluorophosphonate dehalogenase | |
| 4.1.1.124 | malonyl-[acp] decarboxylase | True | 0 | 0 | 0 | 0 | malonyl-[acp] = acetyl-[acp] + CO2 | malonyl-[acyl-carrier protein] carboxy-lyase | None | decarboxylative ketosynthase; bryQ (gene name); mupG (gene name); pksF (gene name); curC (gene name); jamG (gene name); pedM (gene name) | |
| 4.1.1.125 | 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase | True | 0 | 0 | 0 | 0 | a 4-carboxy-3-alkylbut-2-enoyl-[acp] = a 3-alkylbut-2-enoyl-[acp] + CO2 | 4-carboxy-3-alkylbut-2-enoyl-[acyl-carrier protein] carboxy-lyase | None | aprG (gene name); corG (gene name); pedI (gene name); mupK (gene name); 3-carboxymethyl-alk-2-enyl-[acyl-carrier protein] decarboxylase | |
| 4.1.1.126 | anhydromevalonate phosphate decarboxylase | True | 0 | 0 | 0 | 0 | (2E)-3-methyl-5-phosphooxypent-2-enoate = 3-methylbut-3-en-1-yl phosphate + CO2 | (2E)-3-methyl-5-phosphooxypent-2-enoate carboxy-lyase | None | None | |
| 4.2.1.181 | 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase | True | 0 | 0 | 0 | 0 | a 3-carboxymethyl-3-hydroxy-acyl-[acyl-carrier protein] = a 4-carboxy-3-alkylbut-2-enoyl-[acyl-carrier protein] + H2O | 3-carboxymethyl-3-hydroxy-acyl-[acyl-carrier protein] hydro-lyase | None | aprF (gene name); corF (gene name); curE (gene name); pedL (gene name); 3-carboxymethyl-3-hydroxy-acyl-[acyl-carrier protein] dehydratase | |
| 4.2.1.182 | phosphomevalonate dehydratase | True | 0 | 0 | 0 | 0 | (R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2-enoate + H2O | (R)-5-phosphomevalonate hydro-lyase | None | None | |
| 4.2.2.29 | peptidoglycan lytic transglycosylase | False | 5 | 0 | 0 | 0 | a peptidoglycan chain = a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-(peptide) at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end | peptidoglycan N-acetylmuramate---N-acetyl-beta-D-glucosamine lyase | None | lytic murein transglycosylase; endolytic murein transglycosylase; lytic transglycosylase; endolytic transglycosylase; MtlA; MltB; MltC; MltD; MltE; MltF; MltG; Slt; RlpA; SleB; SpoIID | |
| 4.2.3.212 | (+)-delta-cadinol synthase | True | 0 | 0 | 0 | 0 | (2E,6E)-farnesyl diphosphate + H2O = (+)-delta-cadinol + diphosphate | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-delta-cadinol-forming] | None | delta-cadinol synthase (ambiguous) | |
| 4.2.3.213 | colleterpenol synthase | False | 1 | 0 | 0 | 0 | all-trans-hexaprenyl diphosphate + H2O = colleterpenol + diphosphate | pentaprenyl-diphosphate diphosphate-lyase [cyclizing, colleterpenol-forming] | None | CgCS | |
| 4.2.3.214 | dolasta-1(15),8-diene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, dolasta-1(15),8-diene-forming] | None | Cg113742 (gene name); CgDS | |
| 4.2.3.215 | delta-araneosene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = delta-araneosene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, delta-araneosene-forming] | None | None | |
| 4.2.3.216 | somaliensene A synthase | False | 1 | 0 | 0 | 0 | geranylfarnesyl diphosphate = somaliensene A + diphosphate | geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, somaliensene A-forming) | None | stsC (gene name) | |
| 4.2.3.217 | somaliensene B synthase | False | 1 | 0 | 0 | 0 | geranylfarnesyl diphosphate = (-)-somaliensene B + diphosphate | geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-somaliensene B-forming) | None | stsC (gene name) | |
| 4.2.3.218 | variediene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = variediene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, variediene-forming) | None | EvVS | |
| 4.2.3.219 | (2E)-alpha-cericerene synthase | False | 1 | 0 | 0 | 0 | geranylfarnesyl diphosphate = (2E)-alpha-cericerene + diphosphate | geranylfarneyl-diphosphate diphosphate-lyase (cyclizing, (2E)-alpha-cericerene-forming) | None | EvSS | |
| 6.7.1.2 | 3-aminoavenalumate diazotase | True | 0 | 0 | 0 | 0 | ATP + 3-aminoavenalumate + nitrite = AMP + diphosphate + 3-diazoavenalumate + H2O | 3-aminoavenalumate:nitrite ligase (AMP-forming) | None | avaA6 (gene name) | |
| 1.1.1.438 | cis-4-hydroxycyclohexanecarboxylate dehydrogenase | True | 0 | 0 | 0 | 0 | cis-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+ | cis-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase | None | chcB2 (gene name) | |
| 1.5.1.55 | carboxyaminopropylagmatine dehydrogenase | False | 1 | 0 | 0 | 0 | N1-[(S)-3-amino-3-carboxypropyl]agamatine + NADP+ + H2O = agmatine + L-aspartate 4-semialdehyde + NADPH + H+ | N1-[(S)-2-aminobutanoate]agmatine:NADP+ oxidoreductase (agmatine-forming) | None | slr0049 (locus name) | |
| 1.14.13.252 | putrescine N-hydroxylase | True | 0 | 0 | 0 | 0 | putrescine + NADPH + H+ + O2 = N-hydroxyputrescine + NADP+ + H2O | putrescine,NADPH:oxygen oxidoreductase (N-hydroxylating) | None | alcA (gene name); pubA (gene name); fbsI (gene name) | |
| 1.14.14.185 | taxane 9alpha-hydroxylase | True | 0 | 0 | 0 | 0 | 5,20-epoxytax-11-en-4alpha-ol + [reduced NADPH---hemoprotein reductase] + O2 = 5,20-epoxytax-11-ene-4alpha,9alpha-diol + [oxidized NADPH---hemoprotein reductase] + H2O | 5,20-epoxytax-11-en-4alpha-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (9alpha-hydroxylating) | None | taxoid 9alpha hydroxylase; CYP725A22; T9alphaOH | |
| 1.17.3.5 | 4-oxocyclohexanecarboxylate 2-dehydrogenase | True | 0 | 0 | 0 | 0 | 4-oxocyclohexane-1-carboxylate + O2 = 4-oxocyclohex-2-ene-1-carboxylate + H2O2 | 4-oxocyclohexane-1-carboxylate:oxygen oxidoreductase (4-oxocyclohex-2-ene-1-carboxylate-forming) | None | chcC1 (gene name); 4-oxocyclohexanecarboxylate desaturase I; 4-oxocyclohexanecarboxylate 2-desaturase | |
| 2.3.1.314 | phytol O-acyltransferase | True | 0 | 0 | 0 | 0 | an acyl-CoA + phytol = a fatty acid phytyl ester + CoA | acyl-CoA:phytol O-acyltransferase | None | phytyl ester synthase; PES1 (gene name); PES2 (gene name); slr2103 (locus name) | |
| 2.3.1.315 | succinyl-CoA:cyclohexane-1-carboxylate CoA transferase | False | 1 | 0 | 0 | 0 | succinyl-CoA + cyclohexane-1-carboxylate = succinate + cyclohexane-1-carbonyl-CoA | succinyl-CoA---cyclohexane-1-carboxylate CoA-transferase | None | Gmet_3304 (locus name) | |
| 2.3.1.316 | N-hydroxyputrescine acetyltransferase | True | 0 | 0 | 0 | 0 | acetyl-CoA + N-hydroxyputrescine = N1-acetyl-N1-hydroxyputrescine + CoA | acetyl-CoA:N-hydroxyputrescine N-acetyltransferase | None | fbsK (gene name) | |
| 2.4.1.397 | cyclic beta-1,2-glucan glucanotransferase | True | 0 | 0 | 0 | 0 | Cyclizes part of a (1->2)-beta-D-glucan chain by formation of a (1->2)-beta-D-glucosidic bond | (1->2)-beta-D-glucan:(1->2)-beta-D-glucan 2-beta-D-[(1->2)-beta-D-glucano]-transferase (cyclizing and configuration-retaining) | None | None | |
| 2.5.1.158 | hexaprenyl diphosphate synthase (prenyl-diphosphate specific) | False | 3 | 0 | 0 | 0 | prenyl diphosphate + 5 3-methylbut-3-en-1-yl diphosphate = all-trans-hexaprenyl diphosphate + 5 diphosphate | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 5 units of 3-methylbut-3-en-1-yl) | None | HexPPS | |
| 2.5.1.159 | hapalindole G dimethylallyltransferase | True | 0 | 0 | 0 | 0 | (1) prenyl diphosphate + hapalindole G = ambiguine A + diphosphate;;(2) prenyl diphosphate + hapalindole U = ambiguine H + diphosphate | prenyl-diphosphate:hapalindole G prenyltransferase (ambiguine A-forming) | None | ambP3 (gene name); famD1 (gene name) | |
| 2.6.1.125 | L-arginine:2-oxoglutarate transaminase | False | 1 | 0 | 0 | 0 | L-arginine + 2-oxoglutarate = 5-guanidino-2-oxopentanoate + L-glutamate | L-arginine:2-oxoglutarate aminotransferase | None | argM (gene name); arginine-alpha-ketoglutarate transaminase | |
| 2.6.1.126 | L-aspartate:5-guanidino-3-methyl-2-oxopentanoate transaminase | False | 2 | 0 | 0 | 0 | L-aspartate + (3R)-5-guanidino-3-methyl-2-oxopentanoate = oxaloacetate + (3R)-3-methyl-L-arginine | L-aspartate:5-guanidino-3-methyl-2-oxopentanoate aminotransferase | None | argM (gene name); mrsB (gene name) | |
| 2.7.11.36 | MASTL-subfamily protein kinase | True | 0 | 0 | 0 | 0 | (1) ATP + [endosulfine family protein]-L-serine = ADP + [endosulfine family protein]-O-phospho-L-serine;;(2) ATP + [endosulfine family protein]-L-threonine = ADP + [endosulfine family protein]-O-phospho-L-threonine | ATP:[endosulfine family protein] phosphotransferase (Ser/Thr-phosphorylating) | None | MASTL; gwl; greatwall kinase; RIM15; microtubule-associated (MASTL)-subfamily-protein kinase | |
| 2.7.11.37 | MAST-subfamily protein kinase | True | 0 | 0 | 0 | 0 | (1) ATP + [protein]-L-serine = ADP + [protein]-O-phospho-L-serine;;(2) ATP + [protein]-L-threonine = ADP + [protein]-O-phospho-L-threonine | None | None | microtubule-associated serine/threonine-protein kinase; MAST1; MAST2; MAST3; MAST4; MAST205; SAST; IREH1; dop; kin-4 | |
| 3.1.2.33 | betainyl-CoA thioesterase | True | 0 | 0 | 0 | 0 | betaine-CoA + H2O = glycine betaine + CoA | betaine-CoA hydrolase | None | cdhB (gene name) | |
| 3.1.3.110 | 4'-phosphopantetheine phosphatase | True | 0 | 0 | 0 | 0 | 4'-phosphopantetheine + H2O = pantetheine + phosphate | 4'-phosphopantetheine phosphohydrolase | None | thnH (gene name); PANK4 (gene name) | |
| 3.2.1.224 | D-arabinan exo beta-(1,2)-arabinofuranosidase (non-reducing end) | True | 0 | 0 | 0 | 0 | Hydrolysis of terminal non-reducing beta-D-arabinofuranoside residues in D-arabinans | beta-D-arabinofuranoside non-reducing end beta-D-arabinofuranosidase (configuration-retaining) | None | exo-beta-D-arabinofuranosidase; ExoMA2 | |
| 3.2.1.225 | D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end) | True | 0 | 0 | 0 | 0 | Hydrolysis of terminal non-reducing alpha-D-arabinofuranoside residues in D-arabinans | alpha-D-arabinofuranoside non-reducing end alpha-D-arabinofuranosidase (configuration-retaining) | None | exo-alpha-D-arabinofuranosidase; DgGH172a; DgGH172b; DgGH172c; NocGH172; MycGH172; ExoMA1 | |
| 3.2.1.226 | D-arabinan endo alpha-(1,5)-arabinofuranosidase | True | 0 | 0 | 0 | 0 | Hydrolysis of internal alpha-D-arabinofuranoside bonds in D-arabinans | D-arabinan endo alpha-(1,5)-arabinofuranosidase (configuration-retaining) | None | endo-D-arabinanase (ambiguous); DgGH4185a; DgGH4185b; MyxoGH4185; PhageGH4185; Mab4185; EndoMA1; EndoMA2 | |
| 3.5.3.27 | arginine dihydrolase | False | 2 | 0 | 0 | 0 | L-arginine + 2 H2O = L-ornithine + CO2 + 2 ammonia | L-arginine aminodihydrolase (L-ornithine-forming) | None | argZ (gene name) | |
| 3.5.99.12 | salsolinol synthase | True | 0 | 0 | 0 | 0 | (R)-salsolinol + H2O = dopamine + acetaldehyde | (R)-salsolinol dopamine-hydrolase (acetaldehyde-forming) | None | Sal synthase | |
| 3.5.99.13 | strictosidine synthase | False | 5 | 0 | 0 | 0 | 3-alpha(S)-strictosidine + H2O = tryptamine + secologanin | 3-alpha(S)-strictosidine tryptamine-hydrolase (secologanin-forming) | None | strictosidine synthetase; STR; 3-alpha(S)-strictosidine tryptamine-lyase; 3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming) | |
| 3.5.99.14 | (S)-norcoclaurine synthase | False | 5 | 0 | 0 | 0 | (S)-norcoclaurine + H2O = dopamine + 4-hydroxyphenylacetaldehyde | (S)-norcoclaurine dopamine hydrolase (4-hydroxyphenylacetaldehyde-forming) | None | (S)-norlaudanosoline synthase; 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine); 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine, (S)-norcoclaurine-forming] | |
| 3.5.99.15 | deacetylisoipecoside synthase | True | 0 | 0 | 0 | 0 | deacetylisoipecoside + H2O = dopamine + secologanin | deacetylisoipecoside dopamine-hydolase (secologanin-forming) | None | deacetylisoipecoside dopamine-lyase; deacetylisoipecoside dopamine-lyase (secologanin-forming) | |
| 3.5.99.16 | deacetylipecoside synthase | True | 0 | 0 | 0 | 0 | deacetylipecoside + H2O = dopamine + secologanin | deacetylipecoside dopamine-hydroyase (secologanin-forming) | None | deacetylipecoside dopamine-lyase; deacetylipecoside dopamine-lyase (secologanin-forming) | |
| 3.6.1.77 | coenzyme A diphosphatase | False | 13 | 0 | 0 | 0 | coenzyme A + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine | coenzyme A 4'-phosphopantetheine phosphohydrolase | None | CoA pyrophosphatase; coenzyme A pyrophosphatase; CoA diphosphohydrolase; Nudt19; Nudt7; thnR (gene name) | |
| 4.1.1.127 | carboxyaminopropylagmatine decarboxylase | False | 1 | 0 | 0 | 0 | N1-[(S)-3-amino-3-carboxypropyl]agmatine = N1-(3-aminopropyl)agmatine + CO2 | N1-[(S)-3-amino-3-carboxypropyl]agmatine carboxy-lyase | None | sll0873 (locus name) | |
| 4.1.2.65 | ferulate hydratase/lyase | False | 1 | 0 | 0 | 0 | ferulate + H2O = vanillin + acetate (overall reaction);;(1a) ferulate + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate;;(1b) 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate = vanillin + acetate | ferulate acetate-lyase (vanillin-forming) | None | vanillin synthase; VpVan; VAN; ferulate aldolase | |
| 4.1.2.66 | 4-coumarate hydratase/lyase | False | 1 | 0 | 0 | 0 | 4-coumarate + H2O = 4-hydroxybenzaldehyde + acetate (overall reaction);;(1a) 4-coumarate + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoate;;(1b) 3-hydroxy-3-(4-hydroxyphenyl)propanoate = 4-hydroxybenzaldehyde + acetate | 4-coumarate acetate-lyase (4-hydroxybenzaldehyde-forming) | None | 4-hydroxybenzaldehyde synthase; 4HBS | |
| 4.1.99.29 | 5,8-dihydroxy-2-naphthoate synthase | False | 2 | 0 | 0 | 0 | cyclic dehypoxanthine futalosine = 5,8-dihydroxy-2-naphthoate + dihydroxyacetone | cyclic dehypoxanthine futalosine lyase (dihydroxyacetone-forming) | None | mqnD (gene name); 1,4-dihydroxy-6-naphthoate synthase (incorrect) | |
| 4.2.1.183 | etheroleic acid synthase | True | 0 | 0 | 0 | 0 | (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate = (9Z,11E)-12-[(1E)-hex-1-en-1-yloxy]dodeca-9,11-dienoate + H2O | (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate lyase | None | colneleic acid/etheroleic acid synthase; 13/9-DES; 9/13-DES; 13/9-divinyl ether synthase; (9Z,11E)-12-[(1E)-hex-1-en-1-yloxy]dodeca-9,11-dienoate synthase | |
| 4.2.3.220 | talaropentaene synthase | False | 1 | 0 | 0 | 0 | all-trans-hexaprenyl diphosphate = talaropentaene + diphosphate | pentaprenyl-diphosphate diphosphate-lyase [cyclizing, talaropentaene-forming] | None | TvTS | |
| 4.2.3.221 | macrophomene synthase | False | 1 | 0 | 0 | 0 | all-trans-hexaprenyl diphosphate = macrophomene + diphosphate | pentaprenyl-diphosphate diphosphate-lyase [cyclizing, macrophomene-forming] | None | MpMS | |
| 4.2.3.222 | phomopsene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = phomopsene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, phomopsene-formimg) | None | PaPS; NtPS; NrPS; PmS | |
| 4.2.3.223 | bonnadiene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = bonnadiene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, bonnadiene-formimg) | None | BdS | |
| 4.2.3.224 | allokutznerene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = allokutznerene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, allokutznerene-formimg) | None | PmS | |
| 4.2.3.225 | cattleyene synthase | False | 1 | 0 | 0 | 0 | geranylgeranyl diphosphate = cattleyene + diphosphate | geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, cattleyene-formimg) | None | CyS | |
| 4.2.3.226 | (+)-2-epi-prezizaene synthase | False | 1 | 0 | 0 | 0 | (2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate | (2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-2-epi-prezizaene-forming) | None | EAS3 (gene name); EAS4 (gene name) | |
| 4.2.3.227 | (-)-alpha-cedrene synthase | False | 1 | 0 | 0 | 0 | (2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate | (2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-alpha-cedrene-forming) | None | EAS3 (gene name); EAS4 (gene name) | |
| 4.2.3.228 | (Z)-beta-ocimene synthase | True | 0 | 0 | 0 | 0 | geranyl diphosphate = (Z)-beta-ocimene + diphosphate | geranyl diphosphate diphosphate lyase [(Z)-beta-ocimene-forming] | None | CsTPS13PK (gene name) | |
| 4.2.3.229 | ent-beyerene synthase | True | 0 | 0 | 0 | 0 | ent-copalyl diphosphate = ent-beyerene + diphosphate | ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-beyerene-forming) | None | ent-kaurene synthase like 2; RcKSL4; OsKSL2; PpCPS/KS (ambiguous) | |
| 5.5.1.36 | hapalindole U synthase | True | 0 | 0 | 0 | 0 | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole U | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole U-forming) | None | ambU1/ambU4 (gene names); famC4/famC1 (gene names) | |
| 5.6.2.5 | RNA 5'-3' helicase | True | 0 | 0 | 0 | 0 | n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA | RNA 5'-3' helicase (ATP-hydrolysing) | None | corona virus helicase nsP13; MOV10; Moloney leukemia virus 10; UPF1; sen1+ | |
| 5.6.2.6 | RNA 3'-5' helicase | True | 0 | 0 | 0 | 0 | n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA | RNA 3'-5' helicase (ATP-hydrolysing) | None | DEAH/RHA protein; DEAH-box protein 2; Prp22p; DHX8; DHX36; CSFV NS3 helicase; nonstructural protein 3 helicase; KOKV helicase; Kokobera virus helicase; hepatitis C virus NS3 protein; DExH protein; MTR4; SKI2; BRR2; SUV3; Rig-I; retinoic-acid-inducible gene I; DbpA | |
| 5.6.2.7 | DEAD-box RNA helicase | True | 0 | 0 | 0 | 0 | ATP + H2O + wound RNA = ADP + phosphate + unwound RNA | RNA helicase (non-translocating) | None | Dbp2; DDX3; DDX4; DDX5; DDX17; DDX3Y; RM62; hDEAD1; RNA helicase Hera; DED1 | |
| 6.3.2.63 | putrebactin synthase | True | 0 | 0 | 0 | 0 | 2 ATP + 2 N1-hydroxy-N1-succinylputrescine = 2 AMP + 2 diphosphate + putrebactin (overall reaction);;(1a) ATP + 2 N1-hydroxy-N1-succinylputrescine = AMP + diphosphate + pre-putrebactin;;(1b) ATP + pre-putrebactin = AMP + diphosphate + putrebactin | N1-hydroxy-N1-succinylputrescine:N1-hydroxy-N1-succinylputrescine ligase | None | pubC (gene name) | |
| 6.3.2.64 | bisucaberin synthase | False | 1 | 0 | 0 | 0 | 2 ATP + 2 N1-hydroxy-N1-succinylcadaverine = 2 AMP + 2 diphosphate + bisucaberin (overall reaction);;(1a) ATP + 2 N1-hydroxy-N1-succinylcadaverine = AMP + diphosphate + bisucaberin B;;(1b) ATP + bisucaberin B = AMP + diphosphate + bisucaberin | N1-hydroxy-N1-succinylcadaverine:N1-hydroxy-N1-succinylcadaverine ligase | None | pubC (gene name); BibC C-terminal domain | |
| 7.2.1.4 | tetrahydromethanopterin S-methyltransferase | False | 93 | 0 | 0 | 0 | 5-methyl-5,6,7,8-tetrahydromethanopterin + CoM + 2 Na+[side 1] = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na+[side 2] | 5-methyl-5,6,7,8-tetrahydromethanopterin:CoM 2-methyltransferase (Na+-transporting) | None | tetrahydromethanopterin methyltransferase; mtrA-H (gene names); cmtA (gene name); N5-methyltetrahydromethanopterin---coenzyme M methyltransferase; 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase | |
| 1.1.1.439 | 17-dehydrostemmadenine reductase | True | 0 | 0 | 0 | 0 | stemmadenine + NADP+ = 17-dehydrostemmadenine + NADPH + H+ | stemmadenine:NADP+ 17-oxidoreductase | None | Redox2 | |
| 1.1.1.440 | rhazimal reductase | True | 0 | 0 | 0 | 0 | rhazimol + NADP+ = rhazimal + NADPH + H+ | rhazimol:NADP+ oxidoreductase (rhazimol-forming) | None | AsRHR | |
| 1.3.1.127 | vomilenine 19,20-reductase | True | 0 | 0 | 0 | 0 | (20S)-19,20-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+ | (20S)-19,20-dihydrovomilenine:NADP+ 19,20-oxidoreductase | None | RR4 (gene name); vomilenine reductase 2; VR2 (gene name) | |
| 1.3.1.128 | precondylocarpine acetate reductase | True | 0 | 0 | 0 | 0 | dihydroprecondylocarpine acetate + NADP+ = precondylocarpine acetate + NADPH + H+ | precondylocarpine acetate:NADP+ oxidoreductase | None | DPAS (gene name); dihydroprecondylocarpine acetate synthase | |
| 1.5.1.56 | 3,17-didehydrostemmadenine reductase | True | 0 | 0 | 0 | 0 | 17-dehydrostemmadenine + NADP+ = 3,17-didehydrostemmadenine + NADPH + H+ | 17-dehydrostemmadenine:NADP+ 3(4)-oxidoreductase | None | Redox1 | |
| 1.5.3.27 | 2-(methylaminoethyl)phosphonate oxidase | True | 0 | 0 | 0 | 0 | 2-(methylaminoethyl)phosphonate + O2 + H2O = phosphonoacetaldehyde + methylamine + H2O2 | 2-(methylaminoethyl)phosphonate oxidase:oxygen oxidoreductase (phosphonoacetaldehyde-forming) | None | pbfD (gene name); N-methyl-(2-aminoethyl)phosphonate oxidase | |
| 1.13.11.94 | 4-vinylguaiacol dioxygenase | True | 0 | 0 | 0 | 0 | (1) 4-vinylguaiacol + O2 = vanillin + formaldehyde;;(2) 4-vinylphenol + O2 = 4-hydroxybenzaldehyde + formaldehyde | 4-vinylguaiacol:oxygen oxidoreductase | None | Ado; aromatic dioxygenase | |
| 1.14.14.186 | tryptamine 5-hydroxylase | True | 0 | 0 | 0 | 0 | tryptamine + O2 + [reduced NADPH---hemoprotein reductase] = serotonin + H2O + [oxidized NADPH---hemoprotein reductase] | tryptamine,NADPH---hemoprotein reductase:oxygen oxidoreductase (5-hydroxylating) | None | CYP71P1 (gene name) | |
| 1.14.14.187 | rhazimal synthase | True | 0 | 0 | 0 | 0 | geissoschizine + [reduced NADPH---hemoprotein reductase] + O2 = rhazimal + [oxidized NADPH---hemoprotein reductase] + 2 H2O | geissoschizine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (rhazimal forming) | None | RHS (gene name) | |
| 1.14.15.40 | cyclohexane-1-carboxylate 4-trans-hydroxylase | True | 0 | 0 | 0 | 0 | cyclohexane-1-carboxylate + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = trans-4-hydroxycyclohexane-1-carboxylate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | cyclohexane-1-carboxylate,ferredoxin:oxygen oxidoreductase (4-trans-hydroxylating) | None | chcAa (gene name) | |
| 1.14.19.80 | (19E)-geissoschizine oxidase | True | 0 | 0 | 0 | 0 | (19E)-geissoschizine + O2 + [reduced NADPH-hemoprotein reductase] = akuammicine + formate + H2O + [oxidized NADPH-hemoprotein reductase] (overall reaction);;(1a) (19E)-geissoschizine + O2 + [reduced NADPH-hemoprotein reductase] = 3,17-didehydrostemmadenine + 2 H2O + [oxidized NADPH-hemoprotein reductase];;(1b) 3,17-didehydrostemmadenine = 17-dehydropreakuammicine (spontaneous);;(1c) 17-dehydropreakuammicine + H2O = 17-dehydropreakuammicine hydrate (spontaneous);;(1d) 17-dehydropreakuammicine hydrate = akuammicine + formate (spontaneous) | (19E)-geissoschizine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (akuammicine-forming) | None | GO (gene name); CYP71D1V1 (gene name) | |
| 1.14.19.81 | polyneuridine aldehyde synthase | True | 0 | 0 | 0 | 0 | (19E)-geissoschizine + [oxidized NADPH---hemoprotein reductase] + O2 = polyneuridine aldehyde + [reduced NADPH---hemoprotein reductase] + 2 H2O | (19E)-geissoschizine:[oxidized NADPH---hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming) | None | SBE (gene name); sarpagan bridge enzyme; CYP71AY4; CYP71AY5 | |
| 1.21.3.11 | precondylocarpine acetate synthase | True | 0 | 0 | 0 | 0 | stemmadenine acetate + O2 = precondylocarpine acetate + H2O2 | stemmadenine acetate:oxygen oxidoreductase | None | PAS (gene name) | |
| 1.97.1.13 | aliphatic sulfonate oxidoreductase | True | 0 | 0 | 0 | 0 | an aliphatic sulfonate + 2 H2O + 4 oxidized ferredoxin = a carboxylate + sulfite + 4 reduced ferredoxin + 4 H+ (overall reaction);;(1a) an aliphatic sulfonate + H2O + 2 oxidized ferredoxin = an aldehyde + sulfite + 2 reduced ferredoxin + 2 H+;;(1b) an aldehyde + H2O + 2 oxidized ferredoxin = a carboxylate + 2 reduced ferredoxin + 2 H+ | aliphatic sulfonate:ferredoxin oxidoreductase (sulfite-releasing) | None | WOR5; PF1479 (locus name); PF1480 (locus name) | |
| 1.97.1.14 | selenate reductase (quinol) | True | 0 | 0 | 0 | 0 | a quinone + selenite + H2O = a quinol + selenate | quinone:selenite oxidoreductase | None | srdA (gene name); srdB (gene name); srdC (gene name) | |
| 2.1.1.392 | norajmaline N-methyltransferase | True | 0 | 0 | 0 | 0 | S-adenosyl-L-methionine + norajmaline = S-adenosyl-L-homocysteine + ajmaline | S-adenosyl-L-methionine:norajmaline N-methyltransferase | None | NNMT (gene name) | |
| 2.1.1.393 | ajmaline N-methyltransferase | True | 0 | 0 | 0 | 0 | S-adenosyl-L-methionine + ajmaline = S-adenosyl-L-homocysteine + 4-methylajmaline | S-adenosyl-L-methionine:ajmaline N-methyltransferase | None | RsANMT | |
| 2.1.1.394 | 2-(S-pantetheinyl)-carbapenam-3-carboxylate methyltransferase | True | 0 | 0 | 0 | 0 | (1) (2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor;;(2) (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor | S-adenosyl-L-methionine:(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate 6-C-methyltransferase | None | thnK (gene name) | |
| 2.1.1.395 | 7'-O-demethylcephaeline methyltransferase | True | 0 | 0 | 0 | 0 | S-adenosyl-L-methionine + 7'-O-demethylcephaeline = S-adenosyl-L-homocysteine + cephaeline | S-adenosyl-L-methionine:7'-O-demethylcephaeline 7'-O-methyltransferase | None | IpeOMT2; CiOMT1 | |
| 2.1.1.396 | cephaeline 6'-O-methyltransferase | True | 0 | 0 | 0 | 0 | S-adenosyl-L-methionine + cephaeline = S-adenosyl-L-homocysteine + emetine | S-adenosyl-L-methionine:cephaeline 6'-O-methyltransferase | None | IpeOMT1; CiOMT1 | |
| 2.3.1.317 | 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase | True | 0 | 0 | 0 | 0 | 3-dehydrocarnitine + acetyl-CoA = acetoacetate + betainyl-CoA | 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase | None | cdhC (gene name); 3-dehydrocarnitine cleavage enzyme | |
| 2.3.1.318 | 3-oxoadipate:acetyl-CoA acetyltransferase | True | 0 | 0 | 0 | 0 | 3-oxoadipate + acetyl-CoA = acetoacetate + succinyl-CoA | 3-oxoadipate:acetyl-CoA acetyltransferase | None | 3-oxoadipate cleavage enzyme | |
| 2.3.1.319 | 3,5-dioxohexanoate:acetyl-CoA acetone transferase | True | 0 | 0 | 0 | 0 | 3,5-dioxohexanoate + acetyl-CoA = acetoacetate + acetoacetyl-CoA | 3,5-dioxohexanoate:acetyl-CoA acetone transferase | None | 3,5-dioxohexanoate cleavage enzyme | |
| 2.3.1.320 | taxoid C-13 O-(3-amino-3-phenylpropanoyl)transferase | True | 0 | 0 | 0 | 0 | baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + CoA | (3R)-3-amino-3-phenylpropanoyl-CoA:baccatin III C-13 O-((3R)-3-amino-3-phenylpropanoyl)transferase | None | BAPT; baccatin III:3-amino-3-phenylpropanoyltransferase; baccatin III-3-amino-13-phenylpropanoyltransferase; 3'-N-de-benzoyl-2'-deoxytaxol-N-benzoyltransferase | |
| 2.3.1.321 | 3'-N-debenzoyltaxol N-benzoyltransferase | True | 0 | 0 | 0 | 0 | benzoyl-CoA + 3'-N-debenzoyltaxol = CoA + paclitaxel | benzoyl-CoA:3'-N-debenzoyltaxol 3'-N-benzoyltransferase | None | DBTNBT; 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase | |
| 2.3.1.322 | akuammiline synthase | True | 0 | 0 | 0 | 0 | acetyl-CoA + rhazimol = CoA + akuammiline | acetyl-CoA:rhazimol O-acetyltransferase | None | AsAKS1; AsAKS2 | |
| 2.3.1.323 | stemmadenine O-acetyltransferase | True | 0 | 0 | 0 | 0 | acetyl-CoA + stemmadenine = CoA + stemmadenine acetate | acetyl-CoA:stemmadenine O-acetyltransferase | None | SAT (gene name) | |
| 2.4.1.398 | beta-galactofuranoside beta-1,5-galactofuranosyltransferase | True | 0 | 0 | 0 | 0 | UDP-alpha-D-galactofuranose + a beta-D-galactofuranoside = UDP + a beta-D-Galf-(1->5)-beta-D-galactofuranoside | UDP-alpha-D-galactofuranose:beta-D-galactofuranoside beta-1,5-galactofuranosyltransferase (configuration-inverting) | None | gfsA (gene name); O-glycan beta-1,5-galactofuranosyltransferase | |
| 2.5.1.160 | plant cystathionine gamma-synthase | True | 0 | 0 | 0 | 0 | O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate | O-phospho-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase | None | CGS1 (gene name) | |
| 2.7.11.38 | NEK9 subfamily protein kinase | True | 0 | 0 | 0 | 0 | (1) ATP + [protein]-L-serine = ADP + [protein]-O-phospho-L-serine;;(2) ATP + [protein]-L-threonine = ADP + [protein]-O-phospho-L-threonine | ATP:protein Ser/(Thr)-phosphotransferase (NEK9 subfamily) | None | NEK9 subfamily kinase (misleading); serine/threonine-protein kinase Nek9; NEK9 (gene name); NERCC1 (gene name) | |
| 2.7.11.39 | ROCK-subfamily protein kinase | True | 0 | 0 | 0 | 0 | (1) ATP + [protein]-L-serine = ADP + [protein]-O-phospho-L-serine;;(2) ATP + [protein]-L-threonine = ADP + [protein]-O-phospho-L-threonine;;The enzyme has wide range known substrates, mostly involved in cytoskeletal regulation, with a preference for positive charges at P1 to P5. | ATP:cytoskeleton-protein phosphotransferase | None | ROCK; Rho Kinase; ROCK1; ROCK2; rok; let-402; ROCK-I (gene name); ROCK-II (gene name) | |
| 3.1.3.111 | decaprenylphosphoryl-5-phosphoribose phosphatase | True | 0 | 0 | 0 | 0 | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + H2O = trans,octacis-decaprenylphospho-beta-D-ribofuranose + phosphate | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate phosphohydrolase | None | Rv3807c (gene name) | |
| 3.1.3.112 | 4'-phosphooxetanocin A phosphatase | True | 0 | 0 | 0 | 0 | 4'-phosphooxetanocin A + H2O = oxetanocin A + phosphate | [(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate phosphohydrolase | None | oxsA (gene name) | |
| 3.1.4.62 | phosphatidylethanolamine phospholipase C | True | 0 | 0 | 0 | 0 | a phosphatidylethanolamine + H2O = a 1,2-diacyl-sn-glycerol + O-phosphoethanolamine | phosphatidylethanolamine ethanolaminephosphohydrolase | None | phosphatidylethanolamine-specific phospholipase C; PE-PLC; SMSr; SAMD8 (gene name); SMS1 (gene name) | |
| 3.13.2.4 | lanthipeptide synthase | True | 0 | 0 | 0 | 0 | (1) a [protein]-L-serine + a [protein]-L-cysteine = a [protein] with lanthionine crosslink + H2O (overall reaction);;(1a) a [protein]-L-serine = a [protein]-2-aminoprop-2-enoate + H2O;;(1b) a [protein]-2-aminoprop-2-enoate + a [protein]-L-cysteine = a [protein] with lanthionine crosslink;;(2) a [protein]-L-threonine + a [protein]-L-cysteine = a [protein] with 3-methyllanthionine crosslink + H2O (overall reaction);;(2a) a [protein]-L-threonine = a [protein]-(Z)-2-aminobutenoate + H2O;;(2b) a [protein]-(Z)-2-aminobutenoate + a [protein]-L-cysteine = a [protein] with 3-methyllanthionine crosslink | [protein]-(methyl)lanthionine hydrolase | None | lanthipeptide synthetase | |
| 4.1.1.128 | UDP-N-acetyl-alpha-D-glucosaminuronate decarboxylase | True | 0 | 0 | 0 | 0 | UDP-N-acetyl-alpha-D-glucosaminuronate = UDP-N-acety-alpha-D-xylosamine + CO2 | UDP-N-acetyl-alpha-D-glucosaminuronate carboxy-lyase | None | UXNAcS; DP-XylNAc synthase | |
| 4.1.1.129 | 1'-carboxy-chondrochloren decarboxylase | True | 0 | 0 | 0 | 0 | (1) 1'-carboxy-chondrochloren A + FAD = chondrochloren A + CO2 + FADH2;;(2) 1'-carboxy-chondrochloren B + FAD = chondrochloren B + CO2 + FADH2 | 1'-carboxy-chondrochloren carboxy-lyase | None | cndG (gene name) | |
| 4.3.3.9 | indigoidine synthase | True | 0 | 0 | 0 | 0 | 2 ATP + 2 L-glutamine + O2 + 2 FMN = 2 AMP + 2 diphosphate + indigoidine + 2 H2O + 2 FMNH2 (overall reaction);;(1) 2 ATP + 2 L-glutamine + 2 FMN = 2 AMP + 2 diphosphate + 2 3-amino-1,5-dihydropyridine-2,6-dione + FMNH2;;(2) 2 3-amino-1,5-dihydropyridine-2,6-dione + O2 = indigoidine + 2 H2O (spontaneous) | L-glutamine oxidoreductase/cyclase (3-amino-1,5-dihydropyridine-2,6-dione-forming) | None | bspA (gene name) | |
| 5.1.3.45 | UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase | True | 0 | 0 | 0 | 0 | UDP-N-acetyl-alpha-D-glucosaminouronate = UDP-N-acetyl-alpha-D-galactosaminouronate | UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase | None | tviC (gene name); wbpP (gene name); UDP-N-acetylglucosaminuronic acid 4-epimerase | |
| 5.3.99.13 | 4'-phospho-dehydrooxetanocin synthase | True | 0 | 0 | 0 | 0 | dAMP + S-adenosyl-L-methionine = 4'-phospho-dehydrooxetanocin + 5'-deoxyadenosine + L-methionine (overall reaction);;(1a) S-adenosyl-L-methionine + reduced acceptor = 5'-deoxyadenosin-5'-yl radical + L-methionine + acceptor;;(1b) 5'-deoxyadenosin-5'-yl radical + dAMP + acceptor = 4'-phospho-dehydrooxetanocin + 5'-deoxyadenosine + reduced acceptor | dAMP isomerase (4'-phospho-dehydrooxetanocin-forming) | None | oxsB (gene name) | |
| 5.5.1.37 | catharanthine synthase | True | 0 | 0 | 0 | 0 | dehydrosecodine = catharanthine | dehydrosecodine cyclase (catharanthine-forming) | None | CS (gene name) | |
| 5.5.1.38 | tabersonine synthase | True | 0 | 0 | 0 | 0 | dehydrosecodine = tabersonine | dehydrosecodine cyclase (tabersonine-forming) | None | TS (gene name) | |
| 6.3.1.22 | tRNAmet cytidine acetate ligase | True | 0 | 0 | 0 | 0 | ATP + [elongator tRNAMet]-cytidine34 + acetate = AMP + diphosphate + [elongator tRNAMet]-N4-acetylcytidine34 (overall reaction);;(1a) ATP + acetate = acetyladenylate + diphosphate;;(1b) acetyladenylate + [elongator tRNAMet]-cytidine34 = AMP + [elongator tRNAMet]-N4-acetylcytidine34 | elongator tRNAmet cytidine:acetate ligase (AMP-forming) | None | tmcAL (gene name) |
*SwissProt, Trembl and PDB counts are number of protein sequences that were found in the various databases with the given enzyme activity (EC code). Thus, these counts are 0 for orphans.
*Species counts are number of species labelled in Brenda for having the given enzyme activity (EC code).