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All interfaces > All interologs > Interface groups > group130 > 4K4S_A_B,C

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Licorice
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Licorice
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Chain
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Hydrophobicity
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Conservation*

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Rim - Core

Contacts -

4K4S_A
4K4S_B,C
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:18 [ASN] B:598 [A] 3.33 74.68
A:19 [ALA] B:598 [A] 3.93 74.83
A:20 [PRO] B:598 [A] 3.19 70.62
A:20 [PRO] B:599 [G] 3.55 70.62
A:22 [LYS] B:598 [A] 3.62 72.91
A:22 [LYS] B:599 [G] 3.35 base:BB 72.91
A:23 [THR] B:599 [G] 4.74 91.71
A:24 [LYS] B:598 [A] 4.28 57.06
A:24 [LYS] B:599 [G] 2.58 base:SC 57.06
A:43 [LEU] B:599 [G] 4.27 95.53
A:102 [TYR] C:1305 [G] 4.8 B:608 [C] 62.38
A:106 [GLY] B:603 [U] 4.1 C:1310 [A] 49.06
A:107 [LEU] B:602 [C] 4.51 C:1311 [G] 83.38
A:107 [LEU] B:603 [U] 3.7 C:1310 [A] 83.38
A:108 [GLU] B:603 [U] 2.91 C:1310 [A] 77.9
A:108 [GLU] B:604 [C] 4.61 C:1309 [G] 77.9
A:109 [ALA] B:602 [C] 4.95 C:1311 [G] 68.5
A:110 [LEU] B:602 [C] 4.41 C:1311 [G] 79.62
A:111 [ASP] B:601 [U] 4.31 C:1312 [A] 91.19
A:112 [LEU] C:1306 [C] 4.8 B:607 [G] 77.19
A:113 [SER] B:600 [G] 4.87 60.17
A:113 [SER] C:1307 [G] 3.94 B:606 [C] 60.17
A:114 [THR] B:599 [G] 4.69 94.5
A:114 [THR] B:600 [G] 3.41 94.5
A:114 [THR] B:601 [U] 2.87 C:1312 [A] 94.5
A:115 [SER] B:599 [G] 3.06 96.15
A:115 [SER] B:600 [G] 2.72 96.15
A:115 [SER] B:601 [U] 4.19 C:1312 [A] 96.15
A:121 [VAL] B:599 [G] 3.23 64.18
A:126 [LYS] B:597 [C] 3.97 D:1 [G] 75.19
A:126 [LYS] B:598 [A] 3.68 75.19
A:126 [LYS] B:599 [G] 3.85 75.19
A:127 [LYS] B:600 [G] 4.37 96.37
A:127 [LYS] B:601 [U] 2.84 C:1312 [A] 96.37
A:128 [ARG] C:1306 [C] 3.68 B:607 [G] 61.36
A:128 [ARG] C:1307 [G] 3.76 B:606 [C] 61.36
A:133 [LYS] C:1304 [C] 4.85 B:609 [G] 0.57
A:133 [LYS] C:1305 [G] 3.63 B:608 [C] 0.57
A:133 [LYS] C:1306 [C] 3.26 B:607 [G] 0.57
A:134 [GLN] C:1304 [C] 4.08 B:609 [G] 31.49
A:134 [GLN] C:1305 [G] 3.61 B:608 [C] sugar:SC 31.49
A:157 [TYR] B:599 [G] 3.33 79.53
A:159 [LYS] B:600 [G] 2.35 base:SC 98.92
A:159 [LYS] C:1312 [A] 4.87 B:601 [U] 98.92
A:160 [ASP] B:599 [G] 4.04 98.86
A:176 [ILE] B:599 [G] 4.18 90.57
A:176 [ILE] B:600 [G] 3.23 90.57
A:177 [GLU] B:600 [G] 3.37 sugar:BB 88.92
A:178 [ALA] B:600 [G] 3.39 85.64
A:179 [SER] B:600 [G] 3.16 sugar:BB 82.29
A:179 [SER] B:601 [U] 4.53 C:1312 [A] 82.29
A:184 [SER] B:601 [U] 4.03 C:1312 [A] 83.15
A:184 [SER] B:602 [C] 4.85 C:1311 [G] 83.15
A:188 [ARG] B:602 [C] 2.95 C:1311 [G] 96.75
A:195 [TYR] B:602 [C] 4.83 C:1311 [G] 61.71
A:199 [HIS] B:602 [C] 3.64 C:1311 [G] 77.95
A:199 [HIS] B:603 [U] 3.53 C:1310 [A] 77.95
A:209 [ALA] B:603 [U] 4.91 C:1310 [A] 98.46
A:210 [VAL] B:602 [C] 3.97 C:1311 [G] 92.39
A:210 [VAL] B:603 [U] 4.06 C:1310 [A] 92.39
A:211 [GLY] B:603 [U] 3.06 C:1310 [A] sugar:BB 98.43
A:211 [GLY] B:604 [C] 3.69 C:1309 [G] 98.43
A:212 [CYS] B:603 [U] 3.85 C:1310 [A] sugar:BB 78.48
A:212 [CYS] B:604 [C] 3.33 C:1309 [G] 78.48
A:213 [ASP] B:604 [C] 3.25 C:1309 [G] 80.71
A:213 [ASP] B:605 [U] 3.52 C:1308 [A] 80.71
A:214 [PRO] B:604 [C] 3.95 C:1309 [G] 95.67
A:288 [SER] B:600 [G] 2.43 base:BB 99.0
A:288 [SER] B:601 [U] 4.47 C:1312 [A] 99.0
A:289 [GLY] B:600 [G] 2.64 sugar:BB 98.81
A:289 [GLY] B:601 [U] 2.82 C:1312 [A] 98.81
A:290 [CYS] B:600 [G] 4.78 76.26
A:290 [CYS] B:601 [U] 2.79 C:1312 [A] sugar:BB 76.26
A:291 [SER] B:601 [U] 3.63 C:1312 [A] 86.78
A:291 [SER] B:602 [C] 2.82 C:1311 [G] 86.78
A:292 [GLY] B:601 [U] 3.54 C:1312 [A] 80.79
A:293 [THR] B:600 [G] 4.79 98.97
A:293 [THR] B:601 [U] 3.79 C:1312 [A] base:SC 98.97
A:294 [SER] B:602 [C] 4.46 C:1311 [G] 95.07
A:294 [SER] C:1312 [A] 3.8 B:601 [U] base:SC 95.07
A:326 [TYR] B:602 [C] 3.84 C:1311 [G] 98.27
A:326 [TYR] B:603 [U] 3.46 C:1310 [A] 98.27
A:326 [TYR] C:1311 [G] 2.98 B:602 [C] base:SC 98.27
A:326 [TYR] C:1312 [A] 2.63 B:601 [U] sugar:BB 98.27
A:327 [GLY] C:1312 [A] 3.23 B:601 [U] 98.78
A:328 [ASP] C:1312 [A] 2.54 B:601 [U] 98.95
A:329 [ASP] C:1312 [A] 3.52 B:601 [U] 98.95
A:374 [LEU] C:1311 [G] 3.33 B:602 [C] 98.43
A:374 [LEU] C:1312 [A] 4.02 B:601 [U] 98.43
A:375 [LYS] C:1311 [G] 3.11 B:602 [C] 98.3
A:375 [LYS] C:1312 [A] 3.01 B:601 [U] 98.3
A:376 [ARG] C:1310 [A] 4.34 B:603 [U] 98.84
A:376 [ARG] C:1311 [G] 3.9 B:602 [C] sugar:SC 98.84
A:392 [MET] C:1310 [A] 3.41 B:603 [U] 85.05
A:392 [MET] C:1311 [G] 4.0 B:602 [C] 85.05
A:396 [GLU] C:1311 [G] 4.88 B:602 [C] 76.76
A:400 [SER] C:1309 [G] 3.63 B:604 [C] 85.59
A:400 [SER] C:1310 [A] 2.7 B:603 [U] 85.59
A:405 [LYS] C:1309 [G] 4.53 B:604 [C] 89.24
A:409 [ASN] C:1307 [G] 4.29 B:606 [C] 60.13
A:409 [ASN] C:1308 [A] 3.43 B:605 [U] 60.13
A:409 [ASN] C:1309 [G] 4.44 B:604 [C] 60.13
A:412 [ASP] B:607 [G] 3.65 C:1306 [C] sugar:SC 73.74
A:412 [ASP] C:1307 [G] 3.28 B:606 [C] base:SC 73.74
A:412 [ASP] C:1308 [A] 3.98 B:605 [U] 73.74
A:413 [HIS] C:1308 [A] 3.71 B:605 [U] 82.62
A:413 [HIS] C:1309 [G] 3.48 B:604 [C] 82.62
A:413 [HIS] C:1310 [A] 4.53 B:603 [U] 82.62
A:415 [ARG] B:606 [C] 3.7 C:1307 [G] 3.79
A:415 [ARG] B:607 [G] 3.95 C:1306 [C] 3.79
A:416 [SER] B:605 [U] 4.95 C:1308 [A] 93.44
A:416 [SER] B:606 [C] 4.37 C:1307 [G] 93.44
A:416 [SER] C:1308 [A] 4.42 B:605 [U] 93.44
A:416 [SER] C:1309 [G] 3.86 B:604 [C] 93.44
A:417 [LEU] C:1309 [G] 3.91 B:604 [C] 83.26
A:417 [LEU] C:1310 [A] 4.3 B:603 [U] 83.26
A:419 [LEU] B:605 [U] 3.28 C:1308 [A] 0.76
A:419 [LEU] B:606 [C] 3.43 C:1307 [G] 0.76
A:420 [LEU] C:1309 [G] 4.81 B:604 [C] 94.31
A:420 [LEU] C:1310 [A] 3.9 B:603 [U] 94.31
A:456 [ARG] B:606 [C] 3.86 C:1307 [G] 33.58
A:456 [ARG] B:607 [G] 4.11 C:1306 [C] 33.58

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group130 4K4S_A_B,C A: RNA-directed RNA polymerase 3d-pol, Human poliovirus 1 (genetically engineered) B: N/A C: N/A P03300 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases ✘

Interologs

Total number of interologs for this interface: 9

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4K4S_A_B,C 7AAP_A_T 0.66 0.79 1.85 0.0 Adenylyl and guanylyl cyclase catalytic domain-like compare
4K4S_A_B,C 5F8H_A_B,C 0.92 0.99 0.44 0.85 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 5Y6Z_A_B,C 0.88 0.98 0.8 0.87 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 4K4Z_E_F,G 0.95 0.99 0.41 0.91 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6LSG_A_B,C 0.80 0.99 0.75 0.82 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6LSF_A_B,C 0.87 0.98 0.74 0.5 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6KWQ_A_B,C 0.92 0.98 0.61 0.79 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 7BV2_A_T 0.60 0.79 1.56 0.0 Adenylyl and guanylyl cyclase catalytic domain-like compare
3OL9_A_B,C 4K4S_A_B,C 0.96 0.99 0.44 0.95 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare