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All interfaces > All interologs > Interface groups > group130 > 4K4S_A_B,C vs 6LSF_A_B,C

Interface analysis


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Common contacts -

4K4S_A
4K4S_B,C
6LSF_A
6LSF_B,C
Conserved?
A:109 [ALA] B:602 [C] A:109 [ALA] B:602 [G] ✔
A:210 [VAL] B:602 [C] A:210 [VAL] B:602 [G] ✔
A:210 [VAL] B:603 [U] A:210 [VAL] B:603 [U] ✔
A:214 [PRO] B:604 [C] A:214 [PRO] B:604 [C] ✔
A:392 [MET] C:1310 [A] A:393 [MET] C:1307 [A] ✔
A:392 [MET] C:1311 [G] A:393 [MET] C:1308 [C] ✔
A:289 [GLY] B:600 [G] A:290 [GLY] B:600 [A] ✔
A:289 [GLY] B:601 [U] A:290 [GLY] B:601 [G] ✔
A:177 [GLU] B:600 [G] A:177 [GLU] B:600 [A] ✔
A:24 [LYS] B:599 [G] A:24 [LYS] B:599 [C] ✔
A:374 [LEU] C:1311 [G] A:375 [LEU] C:1308 [C] ✔
A:374 [LEU] C:1312 [A] A:375 [LEU] C:1309 [C] ✔
A:108 [GLU] B:603 [U] A:108 [GLU] B:603 [U] ✔
A:20 [PRO] B:599 [G] A:20 [PRO] B:599 [C] ✔
A:107 [LEU] B:603 [U] A:107 [LEU] B:603 [U] ✔
A:178 [ALA] B:600 [G] A:178 [ALA] B:600 [A] ✔
A:329 [ASP] C:1312 [A] A:330 [ASP] C:1309 [C] ✔
A:115 [SER] B:599 [G] A:115 [SER] B:599 [C] ✔
A:115 [SER] B:600 [G] A:115 [SER] B:600 [A] ✔
A:115 [SER] B:601 [U] A:115 [SER] B:601 [G] ✔
A:209 [ALA] B:603 [U] A:209 [ALA] B:603 [U] ✔
A:157 [TYR] B:599 [G] A:157 [TYR] B:599 [C] ✔
A:211 [GLY] B:603 [U] A:211 [GLY] B:603 [U] ✔
A:211 [GLY] B:604 [C] A:211 [GLY] B:604 [C] ✔
A:328 [ASP] C:1312 [A] A:329 [ASP] C:1309 [C] ✔
A:121 [VAL] B:599 [G] A:121 [SER] B:599 [C] ✔
A:405 [LYS] C:1309 [G] A:406 [LYS] C:1306 [G] ✔
A:199 [HIS] B:602 [C] A:199 [HIS] B:602 [G] ✔
A:199 [HIS] B:603 [U] A:199 [HIS] B:603 [U] ✔
A:417 [LEU] C:1309 [G] A:418 [LEU] C:1306 [G] ✔
A:417 [LEU] C:1310 [A] A:418 [LEU] C:1307 [A] ✔
A:412 [ASP] B:607 [G] A:413 [ASP] B:607 [U] ✔
A:412 [ASP] C:1307 [G] A:413 [ASP] C:1304 [G] ✔
A:412 [ASP] C:1308 [A] A:413 [ASP] C:1305 [A] ✔
A:413 [HIS] C:1308 [A] A:414 [HIS] C:1305 [A] ✔
A:413 [HIS] C:1309 [G] A:414 [HIS] C:1306 [G] ✔
A:413 [HIS] C:1310 [A] A:414 [HIS] C:1307 [A] ✔
A:213 [ASP] B:604 [C] A:213 [ASN] B:604 [C] ✔
A:213 [ASP] B:605 [U] A:213 [ASN] B:605 [U] ✔
A:184 [SER] B:601 [U] A:184 [SER] B:601 [G] ✔
A:327 [GLY] C:1312 [A] A:328 [GLY] C:1309 [C] ✔
A:419 [LEU] B:605 [U] A:420 [LEU] B:605 [U] ✔
A:419 [LEU] B:606 [C] A:420 [LEU] B:606 [C] ✔
A:212 [CYS] B:603 [U] A:212 [CYS] B:603 [U] ✔
A:212 [CYS] B:604 [C] A:212 [CYS] B:604 [C] ✔
A:188 [ARG] B:602 [C] A:188 [ARG] B:602 [G] ✔
A:416 [SER] C:1308 [A] A:417 [SER] C:1305 [A] ✔
A:416 [SER] C:1309 [G] A:417 [SER] C:1306 [G] ✔
A:400 [SER] C:1309 [G] A:401 [SER] C:1306 [G] ✔
A:400 [SER] C:1310 [A] A:401 [SER] C:1307 [A] ✔
A:288 [SER] B:600 [G] A:289 [SER] B:600 [A] ✔
A:288 [SER] B:601 [U] A:289 [SER] B:601 [G] ✔
A:294 [SER] B:602 [C] A:295 [SER] B:602 [G] ✔
A:294 [SER] C:1312 [A] A:295 [SER] C:1309 [C] ✔
A:291 [SER] B:601 [U] A:292 [SER] B:601 [G] ✔
A:291 [SER] B:602 [C] A:292 [SER] B:602 [G] ✔
A:106 [GLY] B:603 [U] A:106 [ASN] B:603 [U] ✔
A:176 [ILE] B:599 [G] A:176 [ILE] B:599 [C] ✔
A:176 [ILE] B:600 [G] A:176 [ILE] B:600 [A] ✔
A:111 [ASP] B:601 [U] A:111 [ASP] B:601 [G] ✔
A:420 [LEU] C:1310 [A] A:421 [LEU] C:1307 [A] ✔
A:114 [THR] B:599 [G] A:114 [THR] B:599 [C] ✔
A:114 [THR] B:600 [G] A:114 [THR] B:600 [A] ✔
A:114 [THR] B:601 [U] A:114 [THR] B:601 [G] ✔
A:415 [ARG] B:606 [C] A:416 [ARG] B:606 [C] ✔
A:127 [LYS] B:600 [G] A:127 [LYS] B:600 [A] ✔
A:127 [LYS] B:601 [U] A:127 [LYS] B:601 [G] ✔
A:293 [THR] B:601 [U] A:294 [THR] B:601 [G] ✔
A:290 [CYS] B:600 [G] A:291 [MET] B:600 [A] ✔
A:290 [CYS] B:601 [U] A:291 [MET] B:601 [G] ✔
A:292 [GLY] B:601 [U] A:293 [GLY] B:601 [G] ✔
A:326 [TYR] B:602 [C] A:327 [TYR] B:602 [G] ✔
A:326 [TYR] B:603 [U] A:327 [TYR] B:603 [U] ✔
A:326 [TYR] C:1311 [G] A:327 [TYR] C:1308 [C] ✔
A:326 [TYR] C:1312 [A] A:327 [TYR] C:1309 [C] ✔
A:113 [SER] C:1307 [G] A:113 [HIS] C:1304 [G] ✔
A:133 [LYS] C:1304 [C] A:133 [SER] C:1301 [A] ✔
A:133 [LYS] C:1305 [G] A:133 [SER] C:1302 [G] ✔
A:396 [GLU] C:1311 [G] A:397 [GLU] C:1308 [C] ✔
A:409 [ASN] C:1307 [G] A:410 [ASN] C:1304 [G] ✔
A:409 [ASN] C:1308 [A] A:410 [ASN] C:1305 [A] ✔
A:375 [LYS] C:1311 [G] A:376 [LYS] C:1308 [C] ✔
A:375 [LYS] C:1312 [A] A:376 [LYS] C:1309 [C] ✔
A:179 [SER] B:600 [G] A:179 [SER] B:600 [A] ✔
A:159 [LYS] B:600 [G] A:159 [LYS] B:600 [A] ✔
A:159 [LYS] C:1312 [A] A:159 [LYS] C:1309 [C] ✔
A:376 [ARG] C:1310 [A] A:377 [ARG] C:1307 [A] ✔
A:376 [ARG] C:1311 [G] A:377 [ARG] C:1308 [C] ✔
A:108 [GLU] B:604 [C] A:108 [GLU] B:604 [C] ❌ 6LSF_A_B,C
A:107 [LEU] B:602 [C] A:107 [LEU] B:602 [G] ❌ 6LSF_A_B,C
A:184 [SER] B:602 [C] A:184 [SER] B:602 [G] ❌ 6LSF_A_B,C
A:416 [SER] B:605 [U] A:417 [SER] B:605 [U] ❌ 6LSF_A_B,C
A:416 [SER] B:606 [C] A:417 [SER] B:606 [C] ❌ 6LSF_A_B,C
A:420 [LEU] C:1309 [G] A:421 [LEU] C:1306 [G] ❌ 6LSF_A_B,C
A:415 [ARG] B:607 [G] A:416 [ARG] B:607 [U] ❌ 6LSF_A_B,C
A:293 [THR] B:600 [G] A:294 [THR] B:600 [A] ❌ 6LSF_A_B,C
A:113 [SER] B:600 [G] A:113 [HIS] B:600 [A] ❌ 6LSF_A_B,C
A:110 [LEU] B:602 [C] A:110 [ILE] B:602 [G] ❌ 6LSF_A_B,C
A:133 [LYS] C:1306 [C] A:133 [SER] C:1303 [A] ❌ 6LSF_A_B,C
A:409 [ASN] C:1309 [G] A:410 [ASN] C:1306 [G] ❌ 6LSF_A_B,C
A:179 [SER] B:601 [U] A:179 [SER] B:601 [G] ❌ 6LSF_A_B,C
A:110 [LEU] B:601 [U] A:110 [ILE] B:601 [G] ❌ 4K4S_A_B,C
A:111 [ASP] B:602 [C] A:111 [ASP] B:602 [G] ❌ 4K4S_A_B,C
A:113 [SER] C:1306 [C] A:113 [HIS] C:1303 [A] ❌ 4K4S_A_B,C
A:157 [TYR] B:600 [G] A:157 [TYR] B:600 [A] ❌ 4K4S_A_B,C
A:188 [ARG] B:601 [U] A:188 [ARG] B:601 [G] ❌ 4K4S_A_B,C
A:19 [ALA] B:599 [G] A:19 [GLY] B:599 [C] ❌ 4K4S_A_B,C
A:294 [SER] B:601 [U] A:295 [SER] B:601 [G] ❌ 4K4S_A_B,C
A:412 [ASP] B:606 [C] A:413 [ASP] B:606 [C] ❌ 4K4S_A_B,C
A:412 [ASP] C:1309 [G] A:413 [ASP] C:1306 [G] ❌ 4K4S_A_B,C
A:102 [TYR] C:1305 [G] A:102 [TYR] C:1302 [G] ❌ 6LSF_A:102 no longer at interface
A:128 [ARG] C:1306 [C] A:128 [ARG] C:1303 [A] ❌ 6LSF_A:128 no longer at interface
A:128 [ARG] C:1307 [G] A:128 [ARG] C:1304 [G] ❌ 6LSF_A:128 no longer at interface
A:134 [GLN] C:1304 [C] A:134 [THR] C:1301 [A] ❌ 6LSF_A:134 no longer at interface
A:134 [GLN] C:1305 [G] A:134 [THR] C:1302 [G] ❌ 6LSF_A:134 no longer at interface
A:126 [LYS] B:599 [G] A:126 [LYS] B:599 [C] ❌ 6LSF_A:126 no longer at interface
A:160 [ASP] B:599 [G] A:160 [ASP] B:599 [C] ❌ 6LSF_A:160 no longer at interface
A:22 [LYS] B:599 [G] A:22 [ARG] B:599 [C] ❌ 6LSF_A:22 no longer at interface
A:195 [TYR] B:602 [C] A:195 [TYR] B:602 [G] ❌ 6LSF_A:195 no longer at interface
A:456 [ARG] B:606 [C] A:457 [ASN] B:606 [C] ❌ 6LSF_A:457 no longer at interface
A:456 [ARG] B:607 [G] A:457 [ASN] B:607 [U] ❌ 6LSF_A:457 no longer at interface
A:112 [LEU] C:1306 [C] A:112 [LEU] C:1303 [A] ❌ 6LSF_A:112 no longer at interface
A:23 [THR] B:599 [G] A:23 [THR] B:599 [C] ❌ 6LSF_A:23 no longer at interface
A:43 [LEU] B:599 [G] A:43 [LEU] B:599 [C] ❌ 6LSF_A:43 no longer at interface
A:404 [THR] C:1309 [G] A:405 [THR] C:1306 [G] ❌ 4K4S_A:404 no longer at interface
A:406 [ASP] C:1309 [G] A:407 [ASP] C:1306 [G] ❌ 4K4S_A:406 no longer at interface

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Properties of this pair

Common ECOD label(s)
 Common RFAM label(s)
 Interface TM-score
 Interface RMSD
 Percentage identity
 Protein TM-score
 RNA TM-score
 Protein coverage
 RNA coverage
 Percentage conservation
 Apolar conservation
 H-bond conservation
 Percentage switching out
Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases 0.98 0.74 0.50 0.99 0.43 0.97 1.0 0.87 0.85 0.36 0.42


Other pairs involving 4K4S_A_B,C or 6LSF_A_B,C

Total number of entries: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4K4Z_E_F,G 6LSF_A_B,C 0.87 0.99 0.7 0.44 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
5Y6Z_A_B,C 6LSF_A_B,C 0.93 0.98 0.51 0.44 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 7AAP_A_T 0.66 0.79 1.85 0.0 Adenylyl and guanylyl cyclase catalytic domain-like compare
4K4S_A_B,C 5F8H_A_B,C 0.92 0.99 0.44 0.85 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 5Y6Z_A_B,C 0.88 0.98 0.8 0.87 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 4K4Z_E_F,G 0.95 0.99 0.41 0.91 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6LSG_A_B,C 0.80 0.99 0.75 0.82 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6LSF_A_B,C 0.87 0.98 0.74 0.5 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 6KWQ_A_B,C 0.92 0.98 0.61 0.79 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
4K4S_A_B,C 7BV2_A_T 0.60 0.79 1.56 0.0 Adenylyl and guanylyl cyclase catalytic domain-like compare
5F8H_A_B,C 6LSF_A_B,C 0.94 0.99 0.49 0.65 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
3OL9_A_B,C 6LSF_A_B,C 0.90 0.98 0.62 0.44 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
3OL9_A_B,C 4K4S_A_B,C 0.96 0.99 0.44 0.95 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
3AVX_A_G,T 6LSF_A_B,C 0.58 0.61 2.84 0.1 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
6KWQ_A_B,C 6LSF_A_B,C 0.93 0.99 0.54 0.44 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
6LSF_A_B,C 6LSG_A_B,C 0.86 0.99 0.74 0.67 Adenylyl and guanylyl cyclase catalytic domain-like & helical bundle domain in reverse transcriptase-like polymerases compare
6LSF_A_B,C 7AAP_A_T 0.69 0.8 1.7 0.09 Adenylyl and guanylyl cyclase catalytic domain-like compare
6LSF_A_B,C 7BV2_A_T 0.69 0.8 1.31 0.1 Adenylyl and guanylyl cyclase catalytic domain-like compare