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All interfaces > All interologs > Interface groups > group140 > 4F3T_A_R

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Licorice
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Licorice
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Chain
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Hydrophobicity
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Conservation*

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Rim - Core

Contacts -

4F3T_A
4F3T_R
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:219 [VAL] R:8 [C] 4.43 64.17
A:220 [SER] R:7 [G] 4.86 80.56
A:220 [SER] R:8 [C] 3.49 80.56
A:221 [ALA] R:7 [G] 2.77 sugar:BB 66.07
A:221 [ALA] R:8 [C] 3.33 66.07
A:222 [THR] R:7 [G] 4.66 76.85
A:222 [THR] R:8 [C] 3.09 sugar:SC 76.85
A:222 [THR] R:9 [U] 4.32 76.85
A:223 [ALA] R:8 [C] 4.18 77.84
A:271 [HIS] R:20 [G] 3.09 85.7
A:277 [ARG] R:17 [C] 3.16 72.94
A:277 [ARG] R:19 [G] 3.61 72.94
A:279 [TYR] R:19 [G] 3.64 sugar:SC 50.21
A:294 [PHE] R:20 [G] 3.22 base/AA stacks 91.04
A:295 [PRO] R:20 [G] 3.64 23.81
A:296 [LEU] R:20 [G] 4.05 2.63
A:297 [GLN] R:20 [G] 4.84 32.15
A:308 [VAL] R:20 [G] 3.71 94.63
A:311 [TYR] R:19 [G] 3.12 91.95
A:311 [TYR] R:20 [G] 2.24 91.95
A:312 [PHE] R:20 [G] 3.55 89.64
A:315 [ARG] R:18 [A] 3.47 sugar:SC 49.35
A:315 [ARG] R:19 [G] 2.83 49.35
A:315 [ARG] R:20 [G] 4.89 49.35
A:316 [HIS] R:19 [G] 4.78 85.4
A:316 [HIS] R:20 [G] 3.38 85.4
A:335 [LYS] R:20 [G] 2.99 base:BB 65.22
A:336 [HIS] R:20 [G] 2.76 sugar:BB 26.06
A:337 [THR] R:19 [G] 4.28 51.16
A:337 [THR] R:20 [G] 3.45 51.16
A:338 [TYR] R:20 [G] 2.44 sugar:BB 60.29
A:339 [LEU] R:20 [G] 3.59 57.74
A:351 [ARG] R:8 [C] 3.87 71.49
A:351 [ARG] R:9 [U] 2.16 71.49
A:351 [ARG] R:10 [U] 3.66 71.49
A:353 [ILE] R:9 [U] 4.91 51.48
A:353 [ILE] R:10 [U] 3.32 51.48
A:356 [LEU] R:7 [G] 3.4 81.45
A:361 [THR] R:7 [G] 3.63 71.93
A:364 [MET] R:7 [G] 3.21 79.58
A:364 [MET] R:8 [C] 3.69 79.58
A:365 [ILE] R:6 [U] 3.33 82.15
A:365 [ILE] R:7 [G] 3.67 82.15
A:368 [THR] R:7 [G] 2.7 sugar:SC 79.45
A:369 [ALA] R:6 [U] 3.87 75.53
A:369 [ALA] R:7 [G] 4.97 75.53
A:370 [ARG] R:6 [U] 4.96 34.93
A:375 [ARG] R:7 [G] 4.52 96.45
A:522 [LEU] R:1 [U] 3.51 75.88
A:524 [GLY] R:1 [U] 3.4 base:BB 33.39
A:525 [LYS] R:1 [U] 3.68 48.26
A:526 [THR] R:1 [U] 3.38 base:BB 45.68
A:529 [TYR] R:1 [U] 2.85 base/AA stacks 89.67
A:533 [LYS] R:1 [U] 2.7 98.97
A:544 [THR] R:1 [U] 3.78 94.55
A:545 [GLN] R:1 [U] 2.75 97.98
A:545 [GLN] R:2 [A] 4.6 97.98
A:546 [CYS] R:1 [U] 3.1 89.48
A:546 [CYS] R:2 [A] 4.12 89.48
A:547 [VAL] R:1 [U] 3.85 79.52
A:547 [VAL] R:2 [A] 3.9 79.52
A:548 [GLN] R:1 [U] 2.93 sugar:SC 45.97
A:548 [GLN] R:2 [A] 2.84 45.97
A:551 [ASN] R:2 [A] 2.7 77.08
A:558 [GLN] R:2 [A] 4.42 72.38
A:559 [THR] R:2 [A] 3.51 72.28
A:562 [ASN] R:2 [A] 3.05 base:SC 98.95
A:562 [ASN] R:3 [A] 3.99 98.95
A:563 [LEU] R:2 [A] 3.68 79.89
A:566 [LYS] R:1 [U] 2.92 98.92
A:566 [LYS] R:2 [A] 3.25 98.92
A:566 [LYS] R:3 [A] 2.87 98.92
A:570 [LYS] R:1 [U] 3.14 98.97
A:601 [PRO] R:10 [U] 3.9 85.49
A:602 [PRO] R:10 [U] 2.78 base:BB 68.87
A:634 [HIS] R:10 [U] 4.43 63.33
A:635 [ARG] R:9 [U] 4.89 79.01
A:635 [ARG] R:10 [U] 3.11 base/AA stacks 79.01
A:709 [LYS] R:6 [U] 3.21 98.97
A:710 [ARG] R:9 [U] 3.14 base/AA stacks 95.57
A:710 [ARG] R:10 [U] 2.53 95.57
A:712 [HIS] R:8 [C] 4.1 89.24
A:714 [ARG] R:6 [U] 4.62 97.39
A:714 [ARG] R:7 [G] 2.77 97.39
A:714 [ARG] R:8 [C] 4.24 97.39
A:753 [HIS] R:5 [G] 3.12 94.87
A:753 [HIS] R:6 [U] 3.0 94.87
A:754 [ALA] R:5 [G] 4.3 69.47
A:755 [GLY] R:5 [G] 4.5 83.33
A:756 [ILE] R:4 [A] 3.82 80.58
A:756 [ILE] R:5 [G] 3.53 sugar:BB 80.58
A:757 [GLN] R:5 [G] 2.54 base:SC, sugar:BB 81.7
A:757 [GLN] R:6 [U] 2.94 81.7
A:758 [GLY] R:6 [U] 3.98 98.79
A:759 [THR] R:6 [U] 3.17 98.97
A:759 [THR] R:7 [G] 4.07 98.97
A:760 [SER] R:6 [U] 3.59 92.24
A:761 [ARG] R:6 [U] 2.82 92.3
A:761 [ARG] R:7 [G] 2.85 92.3
A:761 [ARG] R:8 [C] 2.36 92.3
A:790 [TYR] R:3 [A] 4.57 77.59
A:790 [TYR] R:4 [A] 2.85 77.59
A:792 [ARG] R:3 [A] 3.28 95.81
A:792 [ARG] R:4 [A] 2.81 95.81
A:793 [CYS] R:3 [A] 3.22 87.07
A:793 [CYS] R:4 [A] 3.72 87.07
A:795 [ARG] R:3 [A] 4.84 90.1
A:795 [ARG] R:4 [A] 3.46 90.1
A:797 [VAL] R:4 [A] 3.87 94.9
A:797 [VAL] R:5 [G] 3.74 94.9
A:798 [SER] R:4 [A] 4.72 98.81
A:798 [SER] R:5 [G] 2.64 98.81
A:798 [SER] R:6 [U] 4.81 98.81
A:799 [ILE] R:5 [G] 4.75 78.15
A:804 [TYR] R:4 [A] 3.5 81.16
A:804 [TYR] R:5 [G] 2.52 81.16
A:812 [ARG] R:1 [U] 3.23 94.76
A:815 [TYR] R:1 [U] 4.85 0.78
A:859 [ALA] R:1 [U] 4.27 69.53
A:859 [ALA] R:3 [A] 4.63 69.53

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 4F3T_A_R A: Protein argonaute-2, Homo sapiens (genetically engineered) R: Homo sapiens (synthetic) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4F3T_A_R 4OLA_A_B 0.99 0.99 0.3 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5JS1_A_B 0.98 0.99 0.4 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KRE_A_R 0.99 0.98 1.27 0.27 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KRF_A_R 0.97 0.98 1.02 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KXT_A_B 0.98 0.97 1.12 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4F3T_A_R 6OON_A_B 0.98 0.96 1.82 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5O_A_B,D 0.68 0.92 3.24 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5T_A_B,D 0.73 0.92 3.34 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4Z4D_A_B,D 0.70 0.92 3.19 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6CBD_A_B,C 0.79 0.91 3.2 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6MFN_A_C,E 0.84 0.85 1.9 0.21 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4F3T_A_R 5I4A_A_B 0.56 0.77 3.27 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6D92_A_C 0.53 0.71 3.42 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5AWH_A_C 0.59 0.71 3.48 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6OZP_B_C,D 0.53 0.61 2.72 0.05 Ribonuclease H-like compare
4F3T_A_R 6OZS_B_C,D 0.56 0.61 2.75 0.09 Ribonuclease H-like compare
4F3T_A_R 6OZP_A_C,D 0.50 0.61 2.68 0.1 Ribonuclease H-like compare
4F3T_A_R 6OZS_A_C,D 0.49 0.61 2.63 0.1 Ribonuclease H-like compare