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All interfaces > All interologs > Interface groups > group140 > 4F3T_A_R vs 4W5T_A_B,D

Interface analysis


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Common contacts -

4F3T_A
4F3T_R
4W5T_A
4W5T_B,D
Conserved?
A:757 [GLN] R:5 [G] A:757 [GLN] B:5 [C]
A:757 [GLN] R:6 [U] A:757 [GLN] B:6 [A]
A:709 [LYS] R:6 [U] A:709 [LYS] B:6 [A]
A:279 [TYR] R:19 [G] A:279 [TYR] B:21 [U]
A:635 [ARG] R:10 [U] A:635 [ARG] B:10 [C]
A:812 [ARG] R:1 [U] A:812 [ARG] B:1 [U]
A:790 [TYR] R:3 [A] A:790 [TYR] B:3 [C]
A:790 [TYR] R:4 [A] A:790 [TYR] B:4 [A]
A:566 [LYS] R:1 [U] A:566 [LYS] B:1 [U]
A:566 [LYS] R:2 [A] A:566 [LYS] B:2 [U]
A:566 [LYS] R:3 [A] A:566 [LYS] B:3 [C]
A:797 [VAL] R:4 [A] A:797 [VAL] B:4 [A]
A:797 [VAL] R:5 [G] A:797 [VAL] B:5 [C]
A:755 [GLY] R:5 [G] A:755 [GLY] B:5 [C]
A:754 [ALA] R:5 [G] A:754 [ALA] B:5 [C]
A:221 [ALA] R:8 [C] A:221 [ALA] B:8 [U]
A:351 [ARG] R:9 [U] A:351 [ARG] B:9 [G]
A:351 [ARG] R:10 [U] A:351 [ARG] B:10 [C]
A:710 [ARG] R:9 [U] A:710 [ARG] B:9 [G]
A:710 [ARG] R:10 [U] A:710 [ARG] B:10 [C]
A:562 [ASN] R:2 [A] A:562 [ASN] B:2 [U]
A:562 [ASN] R:3 [A] A:562 [ASN] B:3 [C]
A:545 [GLN] R:1 [U] A:545 [GLN] B:1 [U]
A:545 [GLN] R:2 [A] A:545 [GLN] B:2 [U]
A:311 [TYR] R:19 [G] A:311 [TYR] B:21 [U]
A:793 [CYS] R:3 [A] A:793 [CYS] B:3 [C]
A:793 [CYS] R:4 [A] A:793 [CYS] B:4 [A]
A:526 [THR] R:1 [U] A:526 [THR] B:1 [U]
A:601 [PRO] R:10 [U] A:601 [PRO] B:10 [C]
A:375 [ARG] R:7 [G] A:375 [ARG] B:7 [U]
A:753 [HIS] R:5 [G] A:753 [HIS] B:5 [C]
A:753 [HIS] R:6 [U] A:753 [HIS] B:6 [A]
A:522 [LEU] R:1 [U] A:522 [LEU] B:1 [U]
A:220 [SER] R:8 [C] A:220 [SER] B:8 [U]
A:563 [LEU] R:2 [A] A:563 [LEU] B:2 [U]
A:798 [SER] R:4 [A] A:798 [SER] B:4 [A]
A:798 [SER] R:5 [G] A:798 [SER] B:5 [C]
A:798 [SER] R:6 [U] A:798 [SER] B:6 [A]
A:558 [GLN] R:2 [A] A:558 [GLN] B:2 [U]
A:714 [ARG] R:6 [U] A:714 [ARG] B:6 [A]
A:714 [ARG] R:7 [G] A:714 [ARG] B:7 [U]
A:559 [THR] R:2 [A] A:559 [THR] B:2 [U]
A:804 [TYR] R:4 [A] A:804 [TYR] B:4 [A]
A:804 [TYR] R:5 [G] A:804 [TYR] B:5 [C]
A:277 [ARG] R:19 [G] A:277 [ARG] B:21 [U]
A:815 [TYR] R:1 [U] A:815 [TYR] B:1 [U]
A:756 [ILE] R:4 [A] A:756 [ILE] B:4 [A]
A:756 [ILE] R:5 [G] A:756 [ILE] B:5 [C]
A:547 [VAL] R:1 [U] A:547 [VAL] B:1 [U]
A:547 [VAL] R:2 [A] A:547 [VAL] B:2 [U]
A:859 [ALA] R:1 [U] A:859 [ALA] B:1 [U]
A:859 [ALA] R:3 [A] A:859 [ALA] B:3 [C]
A:799 [ILE] R:5 [G] A:799 [ILE] B:5 [C]
A:529 [TYR] R:1 [U] A:529 [TYR] B:1 [U]
A:570 [LYS] R:1 [U] A:570 [LYS] B:1 [U]
A:337 [THR] R:19 [G] A:337 [THR] B:21 [U]
A:368 [THR] R:7 [G] A:368 [THR] B:7 [U]
A:760 [SER] R:6 [U] A:760 [SER] B:6 [A]
A:792 [ARG] R:3 [A] A:792 [ARG] B:3 [C]
A:792 [ARG] R:4 [A] A:792 [ARG] B:4 [A]
A:761 [ARG] R:6 [U] A:761 [ARG] B:6 [A]
A:761 [ARG] R:7 [G] A:761 [ARG] B:7 [U]
A:761 [ARG] R:8 [C] A:761 [ARG] B:8 [U]
A:365 [ILE] R:7 [G] A:365 [ILE] B:7 [U]
A:758 [GLY] R:6 [U] A:758 [GLY] B:6 [A]
A:759 [THR] R:6 [U] A:759 [THR] B:6 [A]
A:759 [THR] R:7 [G] A:759 [THR] B:7 [U]
A:795 [ARG] R:4 [A] A:795 [ARG] B:4 [A]
A:551 [ASN] R:2 [A] A:551 [ASN] B:2 [U]
A:546 [CYS] R:1 [U] A:546 [CYS] B:1 [U]
A:546 [CYS] R:2 [A] A:546 [CYS] B:2 [U]
A:316 [HIS] R:19 [G] A:316 [HIS] B:21 [U]
A:544 [THR] R:1 [U] A:544 [THR] B:1 [U]
A:602 [PRO] R:10 [U] A:602 [PRO] B:10 [C]
A:548 [GLN] R:1 [U] A:548 [GLN] B:1 [U]
A:548 [GLN] R:2 [A] A:548 [GLN] B:2 [U]
A:525 [LYS] R:1 [U] A:525 [LYS] B:1 [U]
A:533 [LYS] R:1 [U] A:533 [LYS] B:1 [U]
A:524 [GLY] R:1 [U] A:524 [GLY] B:1 [U]
A:635 [ARG] R:9 [U] A:635 [ARG] B:9 [G] ❌ 4W5T_A_B,D
A:221 [ALA] R:7 [G] A:221 [ALA] B:7 [U] ❌ 4W5T_A_B,D
A:351 [ARG] R:8 [C] A:351 [ARG] B:8 [U] ❌ 4W5T_A_B,D
A:356 [LEU] R:7 [G] A:356 [LEU] B:7 [U] ❌ 4W5T_A_B,D
A:220 [SER] R:7 [G] A:220 [SER] B:7 [U] ❌ 4W5T_A_B,D
A:714 [ARG] R:8 [C] A:714 [ARG] B:8 [U] ❌ 4W5T_A_B,D
A:365 [ILE] R:6 [U] A:365 [ILE] B:6 [A] ❌ 4W5T_A_B,D
A:795 [ARG] R:3 [A] A:795 [ARG] B:3 [C] ❌ 4W5T_A_B,D
A:361 [THR] R:7 [G] A:361 [THR] B:7 [U] ❌ 4W5T_A_B,D
A:277 [ARG] R:18 [A] A:277 [ARG] B:20 [U] ❌ 4F3T_A_R
A:279 [TYR] R:18 [A] A:279 [TYR] B:20 [U] ❌ 4F3T_A_R
A:295 [PRO] R:19 [G] A:294 [PHE] B:21 [U] ❌ 4F3T_A_R
A:296 [LEU] R:19 [G] A:295 [PRO] B:21 [U] ❌ 4F3T_A_R
A:297 [GLN] R:19 [G] A:296 [LEU] B:21 [U] ❌ 4F3T_A_R
A:308 [VAL] R:19 [G] A:308 [VAL] B:21 [U] ❌ 4F3T_A_R
A:311 [TYR] R:18 [A] A:311 [TYR] B:20 [U] ❌ 4F3T_A_R
A:312 [PHE] R:19 [G] A:312 [PHE] B:21 [U] ❌ 4F3T_A_R
A:336 [HIS] R:19 [G] A:336 [HIS] B:21 [U] ❌ 4F3T_A_R
A:337 [THR] R:18 [A] A:337 [THR] B:20 [U] ❌ 4F3T_A_R
A:338 [TYR] R:19 [G] A:338 [TYR] B:21 [U] ❌ 4F3T_A_R
A:339 [LEU] R:19 [G] A:339 [LEU] B:21 [U] ❌ 4F3T_A_R
A:551 [ASN] R:1 [U] A:551 [ASN] B:1 [U] ❌ 4F3T_A_R
A:602 [PRO] R:9 [U] A:602 [PRO] B:9 [G] ❌ 4F3T_A_R
A:709 [LYS] R:5 [G] A:709 [LYS] B:5 [C] ❌ 4F3T_A_R
A:710 [ARG] R:8 [C] A:710 [ARG] B:8 [U] ❌ 4F3T_A_R
A:710 [ARG] R:7 [G] A:710 [ARG] B:7 [U] ❌ 4F3T_A_R
A:315 [ARG] R:18 [A] A:315 [ARG] B:20 [U] ❌ 4W5T_A:315 no longer at interface
A:315 [ARG] R:19 [G] A:315 [ARG] B:21 [U] ❌ 4W5T_A:315 no longer at interface
A:223 [ALA] R:8 [C] A:223 [ALA] B:8 [U] ❌ 4W5T_A:223 no longer at interface
A:634 [HIS] R:10 [U] A:634 [HIS] B:10 [C] ❌ 4W5T_A:634 no longer at interface
A:369 [ALA] R:6 [U] A:369 [ALA] B:6 [A] ❌ 4W5T_A:369 no longer at interface
A:369 [ALA] R:7 [G] A:369 [ALA] B:7 [U] ❌ 4W5T_A:369 no longer at interface
A:364 [MET] R:7 [G] A:364 [MET] B:7 [U] ❌ 4W5T_A:364 no longer at interface
A:364 [MET] R:8 [C] A:364 [MET] B:8 [U] ❌ 4W5T_A:364 no longer at interface
A:353 [ILE] R:9 [U] A:353 [ILE] B:9 [G] ❌ 4W5T_A:353 no longer at interface
A:353 [ILE] R:10 [U] A:353 [ILE] B:10 [C] ❌ 4W5T_A:353 no longer at interface
A:219 [VAL] R:8 [C] A:219 [VAL] B:8 [U] ❌ 4W5T_A:219 no longer at interface
A:370 [ARG] R:6 [U] A:370 [ARG] B:6 [A] ❌ 4W5T_A:370 no longer at interface
A:222 [THR] R:7 [G] A:222 [THR] B:7 [U] ❌ 4W5T_A:222 no longer at interface
A:222 [THR] R:8 [C] A:222 [THR] B:8 [U] ❌ 4W5T_A:222 no longer at interface
A:222 [THR] R:9 [U] A:222 [THR] B:9 [G] ❌ 4W5T_A:222 no longer at interface
A:712 [HIS] R:8 [C] A:712 [HIS] B:8 [U] ❌ 4W5T_A:712 no longer at interface
A:272 [CYS] R:19 [G] A:271 [HIS] B:21 [U] ❌ 4F3T_A:272 no longer at interface
A:600 [HIS] R:10 [U] A:600 [HIS] B:10 [C] ❌ 4F3T_A:600 no longer at interface
A:600 [HIS] R:9 [U] A:600 [HIS] B:9 [G] ❌ 4F3T_A:600 no longer at interface

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Properties of this pair

Common ECOD label(s)
Common RFAM label(s)
Interface TM-score
Interface RMSD
Percentage identity
Protein TM-score
RNA TM-score
Protein coverage
RNA coverage
Percentage conservation
Apolar conservation
H-bond conservation
Percentage switching out
Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs 0.92 3.34 0.14 0.92 0.35 0.83 0.86 0.73 0.51 0.59 0.42


Other pairs involving 4F3T_A_R or 4W5T_A_B,D

Total number of entries: 35

Interface 1 Interface 2 Percentage conservation
Interface TM-score
Interface RMSD
Percentage identity
Common ECOD label(s)
Common RFAM label(s)
Explore both interfaces
4OLA_A_B 4W5T_A_B,D 0.91 0.93 3.22 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 4W5T_A_B,D 0.89 0.91 3.15 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 4W5T_A_B,D 0.84 0.94 2.2 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4W5T_A_B,D 0.94 0.99 0.26 0.92 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4W5T_A_B,D 0.82 0.93 2.41 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OZS_B_C,D 0.40 0.63 2.8 0.09 Ribonuclease H-like compare
4W5T_A_B,D 5AWH_A_C 0.52 0.72 3.76 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OON_A_B 0.88 0.96 1.87 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6D92_A_C 0.53 0.71 3.89 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OZP_A_C,D 0.54 0.61 2.85 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZS_A_C,D 0.54 0.61 2.93 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZP_B_C,D 0.37 0.63 2.75 0.05 Ribonuclease H-like compare
4W5T_A_B,D 4Z4D_A_B,D 0.91 0.99 0.27 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5JS1_A_B 0.87 0.92 3.34 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5I4A_A_B 0.51 0.78 2.78 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6MFN_A_C,E 0.83 0.93 1.53 0.59 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6CBD_A_B,C 0.94 0.99 0.4 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5O_A_B,D 0.68 0.92 3.24 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6OZP_B_C,D 0.53 0.61 2.72 0.05 Ribonuclease H-like compare
4F3T_A_R 6OZS_B_C,D 0.56 0.61 2.75 0.09 Ribonuclease H-like compare
4F3T_A_R 6OZP_A_C,D 0.50 0.61 2.68 0.1 Ribonuclease H-like compare
4F3T_A_R 6OZS_A_C,D 0.49 0.61 2.63 0.1 Ribonuclease H-like compare
4F3T_A_R 4W5T_A_B,D 0.73 0.92 3.34 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6D92_A_C 0.53 0.71 3.42 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5I4A_A_B 0.56 0.77 3.27 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6CBD_A_B,C 0.79 0.91 3.2 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4OLA_A_B 0.99 0.99 0.3 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KRE_A_R 0.99 0.98 1.27 0.27 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5JS1_A_B 0.98 0.99 0.4 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KXT_A_B 0.98 0.97 1.12 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4F3T_A_R 4KRF_A_R 0.97 0.98 1.02 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5AWH_A_C 0.59 0.71 3.48 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6MFN_A_C,E 0.84 0.85 1.9 0.21 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4F3T_A_R 6OON_A_B 0.98 0.96 1.82 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4Z4D_A_B,D 0.70 0.92 3.19 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare