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All interfaces > All interologs > Interface groups > group140 > 4KRF_A_R vs 4W5T_A_B,D

Interface analysis


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Common contacts -

4KRF_A
4KRF_R
4W5T_A
4W5T_B,D
Conserved?
A:810 [ARG] R:1 [U] A:812 [ARG] B:1 [U] ✔
A:543 [GLN] R:1 [U] A:545 [GLN] B:1 [U] ✔
A:543 [GLN] R:2 [G] A:545 [GLN] B:2 [U] ✔
A:527 [TYR] R:1 [U] A:529 [TYR] B:1 [U] ✔
A:366 [THR] R:7 [A] A:368 [THR] B:7 [U] ✔
A:790 [ARG] R:3 [A] A:792 [ARG] B:3 [C] ✔
A:790 [ARG] R:4 [G] A:792 [ARG] B:4 [A] ✔
A:309 [TYR] R:21 [U] A:311 [TYR] B:20 [U] ✔
A:309 [TYR] R:22 [U] A:311 [TYR] B:21 [U] ✔
A:337 [LEU] R:22 [U] A:339 [LEU] B:21 [U] ✔
A:788 [TYR] R:3 [A] A:790 [TYR] B:3 [C] ✔
A:788 [TYR] R:4 [G] A:790 [TYR] B:4 [A] ✔
A:277 [TYR] R:21 [U] A:279 [TYR] B:20 [U] ✔
A:277 [TYR] R:22 [U] A:279 [TYR] B:21 [U] ✔
A:219 [ALA] R:8 [G] A:221 [ALA] B:8 [U] ✔
A:542 [THR] R:1 [U] A:544 [THR] B:1 [U] ✔
A:797 [ILE] R:5 [G] A:799 [ILE] B:5 [C] ✔
A:791 [CYS] R:3 [A] A:793 [CYS] B:3 [C] ✔
A:791 [CYS] R:4 [G] A:793 [CYS] B:4 [A] ✔
A:363 [ILE] R:7 [A] A:365 [ILE] B:7 [U] ✔
A:544 [CYS] R:1 [U] A:546 [CYS] B:1 [U] ✔
A:544 [CYS] R:2 [G] A:546 [CYS] B:2 [U] ✔
A:755 [GLN] R:5 [G] A:757 [GLN] B:5 [C] ✔
A:755 [GLN] R:6 [U] A:757 [GLN] B:6 [A] ✔
A:560 [ASN] R:2 [G] A:562 [ASN] B:2 [U] ✔
A:560 [ASN] R:3 [A] A:562 [ASN] B:3 [C] ✔
A:349 [ARG] R:9 [U] A:351 [ARG] B:9 [G] ✔
A:349 [ARG] R:10 [A] A:351 [ARG] B:10 [C] ✔
A:813 [TYR] R:1 [U] A:815 [TYR] B:1 [U] ✔
A:802 [TYR] R:4 [G] A:804 [TYR] B:4 [A] ✔
A:802 [TYR] R:5 [G] A:804 [TYR] B:5 [C] ✔
A:306 [VAL] R:22 [U] A:308 [VAL] B:21 [U] ✔
A:568 [LYS] R:1 [U] A:570 [LYS] B:1 [U] ✔
A:545 [VAL] R:1 [U] A:547 [VAL] B:1 [U] ✔
A:545 [VAL] R:2 [G] A:547 [VAL] B:2 [U] ✔
A:796 [SER] R:4 [G] A:798 [SER] B:4 [A] ✔
A:796 [SER] R:5 [G] A:798 [SER] B:5 [C] ✔
A:796 [SER] R:6 [U] A:798 [SER] B:6 [A] ✔
A:793 [ARG] R:4 [G] A:795 [ARG] B:4 [A] ✔
A:708 [ARG] R:8 [G] A:710 [ARG] B:8 [U] ✔
A:708 [ARG] R:9 [U] A:710 [ARG] B:9 [G] ✔
A:708 [ARG] R:10 [A] A:710 [ARG] B:10 [C] ✔
A:751 [HIS] R:5 [G] A:753 [HIS] B:5 [C] ✔
A:751 [HIS] R:6 [U] A:753 [HIS] B:6 [A] ✔
A:294 [LEU] R:22 [U] A:295 [PRO] B:21 [U] ✔
A:601 [ALA] R:10 [A] A:603 [ALA] B:10 [C] ✔
A:520 [LEU] R:1 [U] A:522 [LEU] B:1 [U] ✔
A:522 [GLY] R:1 [U] A:524 [GLY] B:1 [U] ✔
A:557 [THR] R:2 [G] A:559 [THR] B:2 [U] ✔
A:373 [ARG] R:7 [A] A:375 [ARG] B:7 [U] ✔
A:564 [LYS] R:1 [U] A:566 [LYS] B:1 [U] ✔
A:564 [LYS] R:2 [G] A:566 [LYS] B:2 [U] ✔
A:564 [LYS] R:3 [A] A:566 [LYS] B:3 [C] ✔
A:795 [VAL] R:4 [G] A:797 [VAL] B:4 [A] ✔
A:795 [VAL] R:5 [G] A:797 [VAL] B:5 [C] ✔
A:707 [LYS] R:5 [G] A:709 [LYS] B:5 [C] ✔
A:707 [LYS] R:6 [U] A:709 [LYS] B:6 [A] ✔
A:293 [PRO] R:22 [U] A:294 [PHE] B:21 [U] ✔
A:758 [SER] R:6 [U] A:760 [SER] B:6 [A] ✔
A:531 [LYS] R:1 [U] A:533 [LYS] B:1 [U] ✔
A:336 [TYR] R:22 [U] A:338 [TYR] B:21 [U] ✔
A:524 [THR] R:1 [U] A:526 [THR] B:1 [U] ✔
A:561 [LEU] R:2 [G] A:563 [LEU] B:2 [U] ✔
A:556 [GLN] R:2 [G] A:558 [GLN] B:2 [U] ✔
A:754 [ILE] R:4 [G] A:756 [ILE] B:4 [A] ✔
A:754 [ILE] R:5 [G] A:756 [ILE] B:5 [C] ✔
A:757 [THR] R:6 [U] A:759 [THR] B:6 [A] ✔
A:757 [THR] R:7 [A] A:759 [THR] B:7 [U] ✔
A:633 [ARG] R:10 [A] A:635 [ARG] B:10 [C] ✔
A:310 [PHE] R:22 [U] A:312 [PHE] B:21 [U] ✔
A:756 [GLY] R:6 [U] A:758 [GLY] B:6 [A] ✔
A:712 [ARG] R:7 [A] A:714 [ARG] B:7 [U] ✔
A:546 [GLN] R:1 [U] A:548 [GLN] B:1 [U] ✔
A:546 [GLN] R:2 [G] A:548 [GLN] B:2 [U] ✔
A:218 [SER] R:8 [G] A:220 [SER] B:8 [U] ✔
A:759 [ARG] R:6 [U] A:761 [ARG] B:6 [A] ✔
A:759 [ARG] R:7 [A] A:761 [ARG] B:7 [U] ✔
A:759 [ARG] R:8 [G] A:761 [ARG] B:8 [U] ✔
A:314 [TYR] R:22 [U] A:316 [HIS] B:21 [U] ✔
A:752 [ALA] R:5 [G] A:754 [ALA] B:5 [C] ✔
A:523 [LYS] R:1 [U] A:525 [LYS] B:1 [U] ✔
A:275 [ARG] R:21 [U] A:277 [ARG] B:20 [U] ✔
A:549 [ASN] R:1 [U] A:551 [ASN] B:1 [U] ✔
A:549 [ASN] R:2 [G] A:551 [ASN] B:2 [U] ✔
A:334 [HIS] R:22 [U] A:336 [HIS] B:21 [U] ✔
A:753 [GLY] R:5 [G] A:755 [GLY] B:5 [C] ✔
A:857 [ALA] R:1 [U] A:859 [ALA] B:1 [U] ✔
A:857 [ALA] R:3 [A] A:859 [ALA] B:3 [C] ✔
A:335 [THR] R:21 [U] A:337 [THR] B:20 [U] ✔
A:335 [THR] R:22 [U] A:337 [THR] B:21 [U] ✔
A:219 [ALA] R:7 [A] A:221 [ALA] B:7 [U] ❌ 4W5T_A_B,D
A:363 [ILE] R:6 [U] A:365 [ILE] B:6 [A] ❌ 4W5T_A_B,D
A:755 [GLN] R:7 [A] A:757 [GLN] B:7 [U] ❌ 4W5T_A_B,D
A:793 [ARG] R:3 [A] A:795 [ARG] B:3 [C] ❌ 4W5T_A_B,D
A:758 [SER] R:5 [G] A:760 [SER] B:5 [C] ❌ 4W5T_A_B,D
A:175 [VAL] R:9 [U] A:177 [VAL] B:9 [G] ❌ 4W5T_A_B,D
A:354 [LEU] R:7 [A] A:356 [LEU] B:7 [U] ❌ 4W5T_A_B,D
A:756 [GLY] R:7 [A] A:758 [GLY] B:7 [U] ❌ 4W5T_A_B,D
A:712 [ARG] R:8 [G] A:714 [ARG] B:8 [U] ❌ 4W5T_A_B,D
A:359 [THR] R:7 [A] A:361 [THR] B:7 [U] ❌ 4W5T_A_B,D
A:218 [SER] R:7 [A] A:220 [SER] B:7 [U] ❌ 4W5T_A_B,D
A:314 [TYR] R:21 [U] A:316 [HIS] B:20 [U] ❌ 4W5T_A_B,D
A:275 [ARG] R:22 [U] A:277 [ARG] B:21 [U] ❌ 4KRF_A_R
A:601 [ALA] R:9 [U] A:603 [ALA] B:9 [G] ❌ 4KRF_A_R
A:708 [ARG] R:7 [A] A:710 [ARG] B:7 [U] ❌ 4KRF_A_R
A:712 [ARG] R:6 [U] A:714 [ARG] B:6 [A] ❌ 4KRF_A_R
A:710 [HIS] R:8 [G] A:712 [HIS] B:8 [U] ❌ 4W5T_A:712 no longer at interface
A:292 [PHE] R:22 [U] A:293 [THR] B:21 [U] ❌ 4W5T_A:293 no longer at interface
A:220 [THR] R:7 [A] A:222 [THR] B:7 [U] ❌ 4W5T_A:222 no longer at interface
A:220 [THR] R:8 [G] A:222 [THR] B:8 [U] ❌ 4W5T_A:222 no longer at interface
A:220 [THR] R:9 [U] A:222 [THR] B:9 [G] ❌ 4W5T_A:222 no longer at interface
A:362 [MET] R:7 [A] A:364 [MET] B:7 [U] ❌ 4W5T_A:364 no longer at interface
A:362 [MET] R:8 [G] A:364 [MET] B:8 [U] ❌ 4W5T_A:364 no longer at interface
A:217 [VAL] R:8 [G] A:219 [VAL] B:8 [U] ❌ 4W5T_A:219 no longer at interface
A:351 [ILE] R:10 [A] A:353 [ILE] B:10 [C] ❌ 4W5T_A:353 no longer at interface
A:221 [ALA] R:8 [G] A:223 [ALA] B:8 [U] ❌ 4W5T_A:223 no longer at interface
A:313 [LYS] R:21 [U] A:315 [ARG] B:20 [U] ❌ 4W5T_A:315 no longer at interface
A:313 [LYS] R:22 [U] A:315 [ARG] B:21 [U] ❌ 4W5T_A:315 no longer at interface
A:368 [ARG] R:7 [A] A:370 [ARG] B:7 [U] ❌ 4W5T_A:370 no longer at interface
A:271 [GLY] R:22 [U] A:271 [HIS] B:21 [U] ❌ 4KRF_A:271 no longer at interface
A:295 [GLN] R:22 [U] A:296 [LEU] B:21 [U] ❌ 4KRF_A:295 no longer at interface
A:598 [HIS] R:10 [A] A:600 [HIS] B:10 [C] ❌ 4KRF_A:598 no longer at interface
A:598 [HIS] R:9 [U] A:600 [HIS] B:9 [G] ❌ 4KRF_A:598 no longer at interface
A:599 [PRO] R:10 [A] A:601 [PRO] B:10 [C] ❌ 4KRF_A:599 no longer at interface
A:600 [PRO] R:10 [A] A:602 [PRO] B:10 [C] ❌ 4KRF_A:600 no longer at interface
A:600 [PRO] R:9 [U] A:602 [PRO] B:9 [G] ❌ 4KRF_A:600 no longer at interface

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Properties of this pair

Common ECOD label(s)
 Common RFAM label(s)
 Interface TM-score
 Interface RMSD
 Percentage identity
 Protein TM-score
 RNA TM-score
 Protein coverage
 RNA coverage
 Percentage conservation
 Apolar conservation
 H-bond conservation
 Percentage switching out
Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs 0.93 2.41 0.25 0.94 0.44 0.86 1.0 0.82 0.61 0.54 0.56


Other pairs involving 4KRF_A_R or 4W5T_A_B,D

Total number of entries: 35

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 4W5T_A_B,D 0.91 0.93 3.22 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 4W5T_A_B,D 0.89 0.91 3.15 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 4KRF_A_R 0.99 1.0 0.36 0.18 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRE_A_R 4W5T_A_B,D 0.84 0.94 2.2 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4W5T_A_B,D 0.94 0.99 0.26 0.92 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6OON_A_B 0.97 0.98 0.92 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6OZP_B_C,D 0.53 0.62 2.61 0.05 Ribonuclease H-like compare
4KRF_A_R 6D92_A_C 0.62 0.71 4.01 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4OLA_A_B 0.98 0.98 1.1 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6CBD_A_B,C 0.86 0.93 2.39 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4Z4D_A_B,D 0.88 0.93 2.36 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6MFN_A_C,E 0.87 0.86 1.85 0.08 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4KRF_A_R 6OZS_B_C,D 0.55 0.62 2.59 0.09 Ribonuclease H-like compare
4KRF_A_R 4W5O_A_B,D 0.86 0.92 2.36 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 5I4A_A_B 0.59 0.77 2.79 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4KXT_A_B 0.95 0.97 1.54 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRF_A_R 4W5T_A_B,D 0.82 0.93 2.41 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6OZP_A_C,D 0.48 0.62 2.57 0.08 Ribonuclease H-like compare
4KRF_A_R 5AWH_A_C 0.48 0.71 3.98 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 5JS1_A_B 0.98 0.98 1.05 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 6OZS_A_C,D 0.49 0.62 2.57 0.0 Ribonuclease H-like compare
4W5T_A_B,D 6OZS_B_C,D 0.40 0.63 2.8 0.09 Ribonuclease H-like compare
4W5T_A_B,D 5AWH_A_C 0.52 0.72 3.76 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OON_A_B 0.88 0.96 1.87 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6D92_A_C 0.53 0.71 3.89 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OZP_A_C,D 0.54 0.61 2.85 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZS_A_C,D 0.54 0.61 2.93 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZP_B_C,D 0.37 0.63 2.75 0.05 Ribonuclease H-like compare
4W5T_A_B,D 4Z4D_A_B,D 0.91 0.99 0.27 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5JS1_A_B 0.87 0.92 3.34 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5I4A_A_B 0.51 0.78 2.78 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6MFN_A_C,E 0.83 0.93 1.53 0.59 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6CBD_A_B,C 0.94 0.99 0.4 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5T_A_B,D 0.73 0.92 3.34 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KRF_A_R 0.97 0.98 1.02 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare