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All interfaces > All interologs > Interface groups > group140 > 4KXT_A_B vs 4W5O_A_B,D

Interface analysis


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Common contacts -

4KXT_A
4KXT_B
4W5O_A
4W5O_B,D
Conserved?
A:810 [ARG] B:1 [A] A:812 [ARG] B:1 [U] ✔
A:543 [GLN] B:1 [A] A:545 [GLN] B:1 [U] ✔
A:543 [GLN] B:2 [A] A:545 [GLN] B:2 [U] ✔
A:527 [TYR] B:1 [A] A:529 [TYR] B:1 [U] ✔
A:366 [THR] B:7 [A] A:368 [THR] B:7 [U] ✔
A:790 [ARG] B:3 [A] A:792 [ARG] B:3 [C] ✔
A:790 [ARG] B:4 [A] A:792 [ARG] B:4 [A] ✔
A:788 [TYR] B:3 [A] A:790 [TYR] B:3 [C] ✔
A:788 [TYR] B:4 [A] A:790 [TYR] B:4 [A] ✔
A:219 [ALA] B:8 [A] A:221 [ALA] B:8 [U] ✔
A:542 [THR] B:1 [A] A:544 [THR] B:1 [U] ✔
A:797 [ILE] B:5 [A] A:799 [ILE] B:5 [C] ✔
A:791 [CYS] B:3 [A] A:793 [CYS] B:3 [C] ✔
A:791 [CYS] B:4 [A] A:793 [CYS] B:4 [A] ✔
A:363 [ILE] B:6 [A] A:365 [ILE] B:6 [A] ✔
A:363 [ILE] B:7 [A] A:365 [ILE] B:7 [U] ✔
A:544 [CYS] B:1 [A] A:546 [CYS] B:1 [U] ✔
A:544 [CYS] B:2 [A] A:546 [CYS] B:2 [U] ✔
A:755 [GLN] B:5 [A] A:757 [GLN] B:5 [C] ✔
A:755 [GLN] B:6 [A] A:757 [GLN] B:6 [A] ✔
A:560 [ASN] B:2 [A] A:562 [ASN] B:2 [U] ✔
A:560 [ASN] B:3 [A] A:562 [ASN] B:3 [C] ✔
A:813 [TYR] B:1 [A] A:815 [TYR] B:1 [U] ✔
A:802 [TYR] B:4 [A] A:804 [TYR] B:4 [A] ✔
A:802 [TYR] B:5 [A] A:804 [TYR] B:5 [C] ✔
A:568 [LYS] B:1 [A] A:570 [LYS] B:1 [U] ✔
A:545 [VAL] B:1 [A] A:547 [VAL] B:1 [U] ✔
A:545 [VAL] B:2 [A] A:547 [VAL] B:2 [U] ✔
A:796 [SER] B:4 [A] A:798 [SER] B:4 [A] ✔
A:796 [SER] B:5 [A] A:798 [SER] B:5 [C] ✔
A:796 [SER] B:6 [A] A:798 [SER] B:6 [A] ✔
A:793 [ARG] B:4 [A] A:795 [ARG] B:4 [A] ✔
A:751 [HIS] B:5 [A] A:753 [HIS] B:5 [C] ✔
A:751 [HIS] B:6 [A] A:753 [HIS] B:6 [A] ✔
A:520 [LEU] B:1 [A] A:522 [LEU] B:1 [U] ✔
A:522 [GLY] B:1 [A] A:524 [GLY] B:1 [U] ✔
A:557 [THR] B:2 [A] A:559 [THR] B:2 [U] ✔
A:373 [ARG] B:7 [A] A:375 [ARG] B:7 [U] ✔
A:564 [LYS] B:1 [A] A:566 [LYS] B:1 [U] ✔
A:564 [LYS] B:2 [A] A:566 [LYS] B:2 [U] ✔
A:564 [LYS] B:3 [A] A:566 [LYS] B:3 [C] ✔
A:707 [LYS] B:5 [A] A:709 [LYS] B:5 [C] ✔
A:707 [LYS] B:6 [A] A:709 [LYS] B:6 [A] ✔
A:795 [VAL] B:4 [A] A:797 [VAL] B:4 [A] ✔
A:795 [VAL] B:5 [A] A:797 [VAL] B:5 [C] ✔
A:531 [LYS] B:1 [A] A:533 [LYS] B:1 [U] ✔
A:524 [THR] B:1 [A] A:526 [THR] B:1 [U] ✔
A:758 [SER] B:5 [A] A:760 [SER] B:5 [C] ✔
A:758 [SER] B:6 [A] A:760 [SER] B:6 [A] ✔
A:561 [LEU] B:2 [A] A:563 [LEU] B:2 [U] ✔
A:556 [GLN] B:2 [A] A:558 [GLN] B:2 [U] ✔
A:754 [ILE] B:4 [A] A:756 [ILE] B:4 [A] ✔
A:754 [ILE] B:5 [A] A:756 [ILE] B:5 [C] ✔
A:757 [THR] B:6 [A] A:759 [THR] B:6 [A] ✔
A:757 [THR] B:7 [A] A:759 [THR] B:7 [U] ✔
A:313 [LYS] B:19 [A] A:311 [TYR] B:20 [U] ✔
A:756 [GLY] B:6 [A] A:758 [GLY] B:6 [A] ✔
A:712 [ARG] B:7 [A] A:714 [ARG] B:7 [U] ✔
A:546 [GLN] B:1 [A] A:548 [GLN] B:1 [U] ✔
A:546 [GLN] B:2 [A] A:548 [GLN] B:2 [U] ✔
A:759 [ARG] B:6 [A] A:761 [ARG] B:6 [A] ✔
A:759 [ARG] B:7 [A] A:761 [ARG] B:7 [U] ✔
A:759 [ARG] B:8 [A] A:761 [ARG] B:8 [U] ✔
A:752 [ALA] B:5 [A] A:754 [ALA] B:5 [C] ✔
A:523 [LYS] B:1 [A] A:525 [LYS] B:1 [U] ✔
A:549 [ASN] B:2 [A] A:551 [ASN] B:2 [U] ✔
A:753 [GLY] B:5 [A] A:755 [GLY] B:5 [C] ✔
A:857 [ALA] B:1 [A] A:859 [ALA] B:1 [U] ✔
A:857 [ALA] B:3 [A] A:859 [ALA] B:3 [C] ✔
A:219 [ALA] B:7 [A] A:221 [ALA] B:7 [U] ❌ 4W5O_A_B,D
A:349 [ARG] B:8 [A] A:351 [ARG] B:8 [U] ❌ 4W5O_A_B,D
A:349 [ARG] B:9 [A] A:351 [ARG] B:15 [G] ❌ 4W5O_A_B,D
A:712 [ARG] B:6 [A] A:714 [ARG] B:6 [A] ❌ 4W5O_A_B,D
A:712 [ARG] B:8 [A] A:714 [ARG] B:8 [U] ❌ 4W5O_A_B,D
A:359 [THR] B:7 [A] A:361 [THR] B:7 [U] ❌ 4W5O_A_B,D
A:314 [TYR] B:19 [A] A:312 [PHE] B:20 [U] ❌ 4W5O_A_B,D
A:549 [ASN] B:1 [A] A:551 [ASN] B:1 [U] ❌ 4W5O_A_B,D
A:333 [LYS] B:19 [A] A:335 [LYS] B:20 [U] ❌ 4KXT_A_B
A:335 [THR] B:19 [A] A:337 [THR] B:20 [U] ❌ 4KXT_A_B
A:710 [HIS] B:8 [A] A:712 [HIS] B:8 [U] ❌ 4W5O_A:712 no longer at interface
A:710 [HIS] B:9 [A] A:712 [HIS] B:15 [G] ❌ 4W5O_A:712 no longer at interface
A:220 [THR] B:8 [A] A:222 [THR] B:8 [U] ❌ 4W5O_A:222 no longer at interface
A:362 [MET] B:7 [A] A:364 [MET] B:7 [U] ❌ 4W5O_A:364 no longer at interface
A:367 [ALA] B:6 [A] A:369 [ALA] B:6 [A] ❌ 4W5O_A:369 no longer at interface
A:367 [ALA] B:7 [A] A:369 [ALA] B:7 [U] ❌ 4W5O_A:369 no longer at interface
A:217 [VAL] B:8 [A] A:219 [VAL] B:8 [U] ❌ 4W5O_A:219 no longer at interface
A:178 [SER] B:9 [A] A:180 [SER] B:15 [G] ❌ 4W5O_A:180 no longer at interface
A:354 [LEU] B:7 [A] A:356 [LEU] B:7 [U] ❌ 4W5O_A:356 no longer at interface
A:218 [SER] B:7 [A] A:220 [SER] B:7 [U] ❌ 4W5O_A:220 no longer at interface
A:218 [SER] B:8 [A] A:220 [SER] B:8 [U] ❌ 4W5O_A:220 no longer at interface
A:174 [PRO] B:9 [A] A:176 [PRO] B:15 [G] ❌ 4KXT_A:174 no longer at interface
A:276 [LYS] B:19 [A] A:279 [TYR] B:20 [U] ❌ 4KXT_A:276 no longer at interface
A:66 [ARG] B:9 [A] A:68 [ARG] B:15 [G] ❌ 4KXT_A:66 no longer at interface
A:708 [ARG] B:8 [A] A:710 [ARG] B:8 [U] ❌ 4KXT_A:708 no longer at interface
A:95 [LYS] B:9 [A] A:97 [ARG] B:15 [G] ❌ 4KXT_A:95 no longer at interface

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Properties of this pair

Common ECOD label(s)
 Common RFAM label(s)
 Interface TM-score
 Interface RMSD
 Percentage identity
 Protein TM-score
 RNA TM-score
 Protein coverage
 RNA coverage
 Percentage conservation
 Apolar conservation
 H-bond conservation
 Percentage switching out
Ribonuclease H-like & Argonaute, N-terminal domain & SH3 0.91 3.12 0.17 0.91 0.41 0.8 0.83 0.87 0.84 0.68 0.62


Other pairs involving 4KXT_A_B or 4W5O_A_B,D

Total number of entries: 35

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 4W5O_A_B,D 0.92 0.92 3.08 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 6D92_A_C 0.48 0.71 3.26 0.08 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6OZS_A_C,D 0.57 0.59 2.56 0.09 Ribonuclease H-like compare
4KXT_A_B 6OZP_B_C,D 0.48 0.61 2.62 0.05 Ribonuclease H-like compare
4KXT_A_B 5JS1_A_B 0.97 0.98 0.84 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 4W5T_A_B,D 0.89 0.91 3.15 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 5AWH_A_C 0.50 0.71 3.34 0.13 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6CBD_A_B,C 0.91 0.9 2.96 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6OZS_B_C,D 0.51 0.61 2.64 0.09 Ribonuclease H-like compare
4KXT_A_B 4W5O_A_B,D 0.87 0.91 3.12 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 4Z4D_A_B,D 0.87 0.91 2.97 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 5I4A_A_B 0.68 0.77 3.27 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 4OLA_A_B 0.98 0.98 0.92 0.9 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6OZP_A_C,D 0.57 0.6 2.58 0.08 Ribonuclease H-like compare
4KXT_A_B 6OON_A_B 0.95 0.95 2.24 0.83 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6MFN_A_C,E 0.90 0.85 1.72 0.17 Ribonuclease H-like & Argonaute, N-terminal domain compare
4KRE_A_R 4KXT_A_B 0.96 0.96 1.84 0.55 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 4W5O_A_B,D 0.84 0.94 2.22 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 5JS1_A_B 0.88 0.92 3.24 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZS_A_C,D 0.44 0.61 2.76 0.15 Ribonuclease H-like compare
4W5O_A_B,D 5I4A_A_B 0.39 0.78 2.71 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6MFN_A_C,E 0.85 0.92 1.55 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5O_A_B,D 5AWH_A_C 0.59 0.71 3.99 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZP_A_C,D 0.57 0.61 2.77 0.15 Ribonuclease H-like compare
4W5O_A_B,D 6OON_A_B 0.90 0.96 1.89 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4Z4D_A_B,D 0.96 1.0 0.12 0.96 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6D92_A_C 0.59 0.71 4.07 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4W5T_A_B,D 0.94 0.99 0.26 0.92 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6CBD_A_B,C 0.99 1.0 0.36 0.97 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZP_B_C,D 0.48 0.63 2.71 0.1 Ribonuclease H-like compare
4W5O_A_B,D 6OZS_B_C,D 0.49 0.63 2.78 0.14 Ribonuclease H-like compare
4KRF_A_R 4W5O_A_B,D 0.86 0.92 2.36 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4KXT_A_B 0.95 0.97 1.54 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4F3T_A_R 4W5O_A_B,D 0.68 0.92 3.24 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4KXT_A_B 0.98 0.97 1.12 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare