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All interfaces > All interologs > Interface groups > group140 > 4OLA_A_B

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Licorice
Surface

RNA

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Licorice
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Chain
Chain (with hetatm)
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Hydrophobicity
Electrostatics (surface only)
Conservation*

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Rim - Core

Contacts -

4OLA_A
4OLA_B
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:219 [VAL] B:8 [A] 4.37 63.72
A:220 [SER] B:7 [A] 4.75 81.4
A:220 [SER] B:8 [A] 2.98 81.4
A:221 [ALA] B:7 [A] 3.0 sugar:BB 64.68
A:221 [ALA] B:8 [A] 3.66 64.68
A:222 [THR] B:8 [A] 3.66 sugar:SC 78.15
A:222 [THR] B:9 [A] 3.91 78.15
A:279 [TYR] B:21 [U] 4.08 45.44
A:294 [PHE] B:21 [U] 3.09 base/AA stacks 87.72
A:295 [PRO] B:21 [U] 4.48 35.69
A:296 [LEU] B:21 [U] 4.11 0.3
A:308 [VAL] B:21 [U] 4.11 94.99
A:311 [TYR] B:21 [U] 3.08 base/AA stacks 91.68
A:312 [PHE] B:21 [U] 3.36 88.8
A:315 [ARG] B:21 [U] 4.96 47.55
A:316 [HIS] B:21 [U] 2.34 84.48
A:336 [HIS] B:21 [U] 2.93 sugar:BB 13.16
A:337 [THR] B:21 [U] 3.24 46.34
A:338 [TYR] B:21 [U] 2.79 sugar:BB 57.79
A:339 [LEU] B:21 [U] 3.71 57.02
A:351 [ARG] B:8 [A] 4.37 74.01
A:351 [ARG] B:9 [A] 3.55 74.01
A:356 [LEU] B:7 [A] 4.48 78.83
A:361 [THR] B:7 [A] 3.23 73.49
A:364 [MET] B:7 [A] 3.41 82.13
A:364 [MET] B:8 [A] 3.43 82.13
A:365 [ILE] B:6 [A] 3.65 83.05
A:365 [ILE] B:7 [A] 3.39 83.05
A:368 [THR] B:7 [A] 3.01 sugar:SC 78.13
A:369 [ALA] B:6 [A] 3.76 75.72
A:375 [ARG] B:7 [A] 3.79 95.42
A:522 [LEU] B:1 [A] 3.81 74.33
A:524 [GLY] B:1 [A] 3.11 32.98
A:525 [LYS] B:1 [A] 3.75 45.09
A:526 [THR] B:1 [A] 3.19 base:BB, base:BB 49.81
A:529 [TYR] B:1 [A] 2.7 base/AA stacks 91.3
A:533 [LYS] B:1 [A] 2.66 98.97
A:544 [THR] B:1 [A] 3.82 93.7
A:545 [GLN] B:1 [A] 2.91 98.49
A:545 [GLN] B:2 [A] 4.6 98.49
A:546 [CYS] B:1 [A] 2.86 86.84
A:546 [CYS] B:2 [A] 4.02 86.84
A:547 [VAL] B:1 [A] 3.86 76.06
A:547 [VAL] B:2 [A] 3.62 76.06
A:548 [GLN] B:1 [A] 3.46 base:SC 46.48
A:548 [GLN] B:2 [A] 2.83 46.48
A:551 [ASN] B:1 [A] 4.88 80.73
A:551 [ASN] B:2 [A] 2.67 80.73
A:558 [GLN] B:2 [A] 4.43 76.19
A:559 [THR] B:2 [A] 3.61 72.54
A:562 [ASN] B:2 [A] 3.01 base:SC 98.97
A:562 [ASN] B:3 [A] 4.03 98.97
A:563 [LEU] B:2 [A] 3.71 82.43
A:566 [LYS] B:1 [A] 3.08 98.97
A:566 [LYS] B:2 [A] 3.32 98.97
A:566 [LYS] B:3 [A] 2.46 98.97
A:570 [LYS] B:1 [A] 3.61 98.89
A:709 [LYS] B:6 [A] 3.01 98.95
A:710 [ARG] B:8 [A] 4.25 95.26
A:710 [ARG] B:9 [A] 3.23 95.26
A:712 [HIS] B:8 [A] 3.99 90.01
A:714 [ARG] B:6 [A] 4.72 97.55
A:714 [ARG] B:7 [A] 2.52 97.55
A:714 [ARG] B:8 [A] 4.95 97.55
A:753 [HIS] B:5 [A] 3.21 93.4
A:753 [HIS] B:6 [A] 2.87 93.4
A:754 [ALA] B:5 [A] 4.13 66.92
A:755 [GLY] B:5 [A] 4.25 84.33
A:756 [ILE] B:4 [A] 3.59 77.86
A:756 [ILE] B:5 [A] 3.29 sugar:BB 77.86
A:757 [GLN] B:5 [A] 3.57 sugar:BB 81.13
A:757 [GLN] B:6 [A] 3.17 base:SC 81.13
A:758 [GLY] B:6 [A] 4.33 98.6
A:759 [THR] B:6 [A] 3.33 99.0
A:759 [THR] B:7 [A] 3.83 99.0
A:760 [SER] B:5 [A] 4.95 93.0
A:760 [SER] B:6 [A] 3.49 93.0
A:761 [ARG] B:6 [A] 2.73 92.3
A:761 [ARG] B:7 [A] 2.47 92.3
A:761 [ARG] B:8 [A] 2.41 92.3
A:790 [TYR] B:3 [A] 4.36 76.85
A:790 [TYR] B:4 [A] 2.72 76.85
A:792 [ARG] B:3 [A] 3.41 97.09
A:792 [ARG] B:4 [A] 2.74 97.09
A:793 [CYS] B:3 [A] 3.26 83.66
A:793 [CYS] B:4 [A] 3.69 83.66
A:795 [ARG] B:4 [A] 3.71 90.82
A:797 [VAL] B:4 [A] 3.81 95.34
A:797 [VAL] B:5 [A] 3.89 95.34
A:798 [SER] B:4 [A] 4.73 98.81
A:798 [SER] B:5 [A] 2.66 98.81
A:798 [SER] B:6 [A] 4.69 98.81
A:799 [ILE] B:5 [A] 4.82 77.74
A:804 [TYR] B:4 [A] 3.57 79.26
A:804 [TYR] B:5 [A] 2.65 79.26
A:812 [ARG] B:1 [A] 3.13 94.51
A:815 [TYR] B:1 [A] 3.55 base:SC 3.93
A:859 [ALA] B:1 [A] 4.18 69.54
A:859 [ALA] B:3 [A] 4.46 69.54

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 4OLA_A_B A: Protein argonaute-2, Homo sapiens (genetically engineered) B: Homo sapiens (genetically engineered) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 6OZS_B_C,D 0.51 0.6 2.64 0.09 Ribonuclease H-like compare
4OLA_A_B 6OZP_B_C,D 0.50 0.6 2.63 0.05 Ribonuclease H-like compare
4OLA_A_B 6MFN_A_C,E 0.88 0.86 1.81 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4OLA_A_B 4W5O_A_B,D 0.92 0.92 3.08 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 6OZS_A_C,D 0.57 0.6 2.63 0.1 Ribonuclease H-like compare
4OLA_A_B 5AWH_A_C 0.63 0.71 3.34 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 6OZP_A_C,D 0.58 0.6 2.64 0.1 Ribonuclease H-like compare
4OLA_A_B 5I4A_A_B 0.61 0.77 3.22 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 4W5T_A_B,D 0.91 0.93 3.22 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 4Z4D_A_B,D 0.95 0.93 3.04 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 6CBD_A_B,C 0.95 0.91 3.17 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 6OON_A_B 0.99 0.95 1.78 0.9 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 6D92_A_C 0.61 0.7 3.32 0.1 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 5JS1_A_B 0.99 1.0 0.31 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 4OLA_A_B 0.98 0.98 0.92 0.9 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 4OLA_A_B 1.00 0.97 1.39 0.5 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4OLA_A_B 0.98 0.98 1.1 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4OLA_A_B 0.99 0.99 0.3 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare