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All interfaces > All interologs > Interface groups > group140 > 4W5T_A_B,D

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Licorice
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Licorice
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Chain
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Hydrophobicity
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Conservation*

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Rim - Core

Contacts -

4W5T_A
4W5T_B,D
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:68 [ARG] B:13 [A] 4.81 47.55
A:68 [ARG] B:14 [A] 2.63 47.55
A:176 [PRO] B:14 [A] 4.0 39.6
A:177 [VAL] B:14 [A] 4.02 71.65
A:178 [GLY] B:13 [A] 3.82 78.91
A:178 [GLY] B:14 [A] 3.32 sugar:BB 78.91
A:179 [ARG] B:13 [A] 3.2 78.63
A:220 [SER] B:8 [U] 4.2 D:23 [C] 80.49
A:221 [ALA] B:8 [U] 4.28 D:23 [C] 62.77
A:271 [HIS] B:21 [U] 4.03 86.51
A:277 [ARG] B:20 [U] 3.61 69.17
A:277 [ARG] B:21 [U] 4.27 69.17
A:279 [TYR] B:20 [U] 3.75 40.73
A:279 [TYR] B:21 [U] 4.12 40.73
A:294 [PHE] B:21 [U] 3.35 base/AA stacks 88.3
A:295 [PRO] B:21 [U] 4.56 35.29
A:296 [LEU] B:21 [U] 3.91 2.9
A:308 [VAL] B:21 [U] 4.02 94.59
A:311 [TYR] B:20 [U] 4.25 91.17
A:311 [TYR] B:21 [U] 2.86 91.17
A:312 [PHE] B:21 [U] 3.63 87.91
A:316 [HIS] B:21 [U] 3.57 80.84
A:336 [HIS] B:21 [U] 2.79 base:SC, sugar:BB 25.89
A:337 [THR] B:20 [U] 4.09 50.35
A:337 [THR] B:21 [U] 3.35 50.35
A:338 [TYR] B:21 [U] 2.52 sugar:BB 60.15
A:339 [LEU] B:21 [U] 4.04 55.56
A:351 [ARG] B:9 [G] 4.76 72.1
A:351 [ARG] B:10 [C] 4.32 72.1
A:356 [LEU] D:24 [A] 4.97 B:7 [U] 82.66
A:357 [THR] D:24 [A] 4.38 B:7 [U] 68.35
A:358 [ASP] D:24 [A] 3.12 B:7 [U] 43.89
A:358 [ASP] D:25 [U] 3.09 B:6 [A] 43.89
A:361 [THR] D:24 [A] 3.65 B:7 [U] sugar:SC 75.91
A:361 [THR] D:25 [U] 3.33 B:6 [A] 75.91
A:362 [SER] D:25 [U] 3.28 B:6 [A] 66.88
A:362 [SER] D:26 [G] 3.53 B:5 [C] 66.88
A:365 [ILE] B:7 [U] 3.24 D:24 [A] 85.21
A:365 [ILE] D:25 [U] 3.32 B:6 [A] 85.21
A:365 [ILE] D:26 [G] 4.1 B:5 [C] 85.21
A:368 [THR] B:7 [U] 4.05 D:24 [A] 77.84
A:375 [ARG] B:7 [U] 4.34 D:24 [A] 97.48
A:434 [VAL] D:30 [A] 4.07 53.8
A:435 [TRP] D:30 [A] 4.54 84.61
A:436 [ASP] D:30 [A] 4.22 82.04
A:437 [MET] D:30 [A] 3.79 64.3
A:438 [ARG] D:30 [A] 3.16 60.16
A:477 [ILE] D:30 [A] 3.82 41.56
A:522 [LEU] B:1 [U] 3.57 72.74
A:524 [GLY] B:1 [U] 3.0 base:BB 15.06
A:525 [LYS] B:1 [U] 3.6 44.4
A:525 [LYS] D:23 [C] 3.85 B:8 [U] 44.4
A:525 [LYS] D:24 [A] 3.05 B:7 [U] 44.4
A:526 [THR] B:1 [U] 3.18 base:BB 51.8
A:529 [TYR] B:1 [U] 2.64 base/AA stacks 91.28
A:533 [LYS] B:1 [U] 2.66 98.97
A:544 [THR] B:1 [U] 4.01 92.38
A:545 [GLN] B:1 [U] 2.89 98.67
A:545 [GLN] B:2 [U] 4.65 D:29 [A] 98.67
A:546 [CYS] B:1 [U] 2.98 87.28
A:546 [CYS] B:2 [U] 4.04 D:29 [A] 87.28
A:547 [VAL] B:1 [U] 3.77 78.52
A:547 [VAL] B:2 [U] 3.39 D:29 [A] 78.52
A:548 [GLN] B:1 [U] 3.46 41.25
A:548 [GLN] B:2 [U] 2.96 D:29 [A] 41.25
A:551 [ASN] B:1 [U] 4.85 78.41
A:551 [ASN] B:2 [U] 2.74 D:29 [A] 78.41
A:557 [PRO] D:30 [A] 3.68 28.38
A:558 [GLN] B:2 [U] 4.41 D:29 [A] 74.74
A:558 [GLN] D:29 [A] 3.0 B:2 [U] sugar:SC 74.74
A:558 [GLN] D:30 [A] 3.27 74.74
A:559 [THR] B:2 [U] 3.46 D:29 [A] 71.6
A:559 [THR] D:29 [A] 4.55 B:2 [U] 71.6
A:561 [SER] D:30 [A] 2.86 base:SC 71.29
A:562 [ASN] B:2 [U] 2.92 D:29 [A] base:SC 98.83
A:562 [ASN] B:3 [C] 4.01 D:28 [G] 98.83
A:562 [ASN] D:29 [A] 3.76 B:2 [U] 98.83
A:563 [LEU] B:2 [U] 3.34 D:29 [A] 81.27
A:566 [LYS] B:1 [U] 2.98 98.89
A:566 [LYS] B:2 [U] 3.11 D:29 [A] 98.89
A:566 [LYS] B:3 [C] 2.92 D:28 [G] 98.89
A:570 [LYS] B:1 [U] 3.08 98.92
A:600 [HIS] B:9 [G] 4.89 98.06
A:600 [HIS] B:10 [C] 3.15 98.06
A:600 [HIS] B:11 [C] 3.21 98.06
A:601 [PRO] B:10 [C] 2.9 sugar:BB 83.82
A:602 [PRO] B:9 [G] 3.88 63.83
A:602 [PRO] B:10 [C] 4.08 63.83
A:602 [PRO] D:22 [A] 4.39 63.83
A:603 [ALA] B:9 [G] 2.87 sugar:BB 67.54
A:603 [ALA] B:10 [C] 3.7 67.54
A:635 [ARG] B:10 [C] 2.37 sugar:SC 78.42
A:635 [ARG] B:11 [C] 3.26 78.42
A:635 [ARG] B:12 [C] 4.74 78.42
A:637 [GLU] B:11 [C] 3.21 95.66
A:670 [GLY] B:11 [C] 3.49 97.92
A:671 [VAL] B:11 [C] 4.43 95.39
A:672 [SER] B:11 [C] 3.53 95.0
A:672 [SER] B:12 [C] 3.13 95.0
A:674 [GLY] B:12 [C] 4.04 88.05
A:675 [GLN] B:11 [C] 2.54 base:SC, sugar:SC, sugar:SC 90.29
A:675 [GLN] B:12 [C] 3.11 90.29
A:709 [LYS] B:5 [C] 4.92 D:26 [G] 98.92
A:709 [LYS] B:6 [A] 2.88 D:25 [U] 98.92
A:710 [ARG] B:7 [U] 4.2 D:24 [A] 95.06
A:710 [ARG] B:8 [U] 3.36 D:23 [C] base:SC 95.06
A:710 [ARG] B:9 [G] 4.77 95.06
A:710 [ARG] B:10 [C] 4.6 95.06
A:714 [ARG] B:6 [A] 4.51 D:25 [U] 97.81
A:714 [ARG] B:7 [U] 2.7 D:24 [A] 97.81
A:726 [LYS] D:28 [G] 3.71 B:3 [C] 75.33
A:753 [HIS] B:5 [C] 3.16 D:26 [G] 93.54
A:753 [HIS] B:6 [A] 2.86 D:25 [U] 93.54
A:754 [ALA] B:5 [C] 3.93 D:26 [G] 62.19
A:755 [GLY] B:5 [C] 4.1 D:26 [G] 84.88
A:756 [ILE] B:4 [A] 4.67 D:27 [U] 81.72
A:756 [ILE] B:5 [C] 3.21 D:26 [G] sugar:BB 81.72
A:756 [ILE] D:27 [U] 3.57 B:4 [A] 81.72
A:756 [ILE] D:28 [G] 4.08 B:3 [C] 81.72
A:757 [GLN] B:5 [C] 3.59 D:26 [G] sugar:BB 81.6
A:757 [GLN] B:6 [A] 3.04 D:25 [U] sugar:SC 81.6
A:757 [GLN] D:26 [G] 3.46 B:5 [C] 81.6
A:757 [GLN] D:27 [U] 3.99 B:4 [A] 81.6
A:758 [GLY] B:6 [A] 4.16 D:25 [U] 98.45
A:759 [THR] B:6 [A] 3.28 D:25 [U] 99.0
A:759 [THR] B:7 [U] 3.93 D:24 [A] 99.0
A:760 [SER] B:6 [A] 3.59 D:25 [U] 92.82
A:761 [ARG] B:6 [A] 2.87 D:25 [U] 89.71
A:761 [ARG] B:7 [U] 2.54 D:24 [A] 89.71
A:761 [ARG] B:8 [U] 3.2 D:23 [C] 89.71
A:790 [TYR] B:3 [C] 4.23 D:28 [G] 77.99
A:790 [TYR] B:4 [A] 2.55 D:27 [U] 77.99
A:792 [ARG] B:3 [C] 3.44 D:28 [G] 95.99
A:792 [ARG] B:4 [A] 3.05 D:27 [U] 95.99
A:793 [CYS] B:3 [C] 3.23 D:28 [G] 82.07
A:793 [CYS] B:4 [A] 3.79 D:27 [U] 82.07
A:795 [ARG] B:4 [A] 3.11 D:27 [U] sugar:SC 89.4
A:797 [VAL] B:4 [A] 3.93 D:27 [U] 95.14
A:797 [VAL] B:5 [C] 3.74 D:26 [G] 95.14
A:798 [SER] B:4 [A] 4.73 D:27 [U] 98.86
A:798 [SER] B:5 [C] 2.92 D:26 [G] 98.86
A:798 [SER] B:6 [A] 4.57 D:25 [U] 98.86
A:799 [ILE] B:5 [C] 4.96 D:26 [G] 77.55
A:804 [TYR] B:4 [A] 3.63 D:27 [U] 80.3
A:804 [TYR] B:5 [C] 2.71 D:26 [G] 80.3
A:811 [PHE] D:22 [A] 3.14 23.44
A:811 [PHE] D:23 [C] 3.86 B:8 [U] 23.44
A:812 [ARG] B:1 [U] 3.48 95.25
A:815 [TYR] B:1 [U] 4.6 0.58
A:815 [TYR] D:23 [C] 4.26 B:8 [U] 0.58
A:859 [ALA] B:1 [U] 4.2 69.54
A:859 [ALA] B:3 [C] 4.46 D:28 [G] 69.54

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 4W5T_A_B,D A: Protein argonaute-2, Homo sapiens (genetically engineered) B: Synthetic construct (synthetic) D: Synthetic construct (synthetic) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 4W5T_A_B,D 0.91 0.93 3.22 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 4W5T_A_B,D 0.89 0.91 3.15 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 4W5T_A_B,D 0.84 0.94 2.2 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4W5T_A_B,D 0.94 0.99 0.26 0.92 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4W5T_A_B,D 0.82 0.93 2.41 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OZS_B_C,D 0.40 0.63 2.8 0.09 Ribonuclease H-like compare
4W5T_A_B,D 5AWH_A_C 0.52 0.72 3.76 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OON_A_B 0.88 0.96 1.87 0.42 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6D92_A_C 0.53 0.71 3.89 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6OZP_A_C,D 0.54 0.61 2.85 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZS_A_C,D 0.54 0.61 2.93 0.1 Ribonuclease H-like compare
4W5T_A_B,D 6OZP_B_C,D 0.37 0.63 2.75 0.05 Ribonuclease H-like compare
4W5T_A_B,D 4Z4D_A_B,D 0.91 0.99 0.27 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5JS1_A_B 0.87 0.92 3.34 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5I4A_A_B 0.51 0.78 2.78 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6MFN_A_C,E 0.83 0.93 1.53 0.59 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6CBD_A_B,C 0.94 0.99 0.4 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5T_A_B,D 0.73 0.92 3.34 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare