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All interfaces > All interologs > Interface groups > group140 > 4Z4D_A_B,D

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Licorice
Surface

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Licorice
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Chain
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Hydrophobicity
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Conservation*

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Rim - Core

Contacts -

4Z4D_A
4Z4D_B,D
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:65 [LYS] B:16 [U] 4.62 2.58
A:65 [LYS] B:17 [C] 3.46 2.58
A:66 [CYS] B:17 [C] 3.99 2.82
A:67 [PRO] B:16 [U] 3.77 53.65
A:67 [PRO] B:17 [C] 3.44 53.65
A:68 [ARG] B:13 [A] 4.98 48.95
A:68 [ARG] B:14 [A] 2.62 48.95
A:68 [ARG] B:15 [G] 2.97 48.95
A:68 [ARG] B:16 [U] 4.09 48.95
A:70 [VAL] B:17 [C] 3.72 41.95
A:97 [ARG] B:14 [A] 2.95 59.01
A:97 [ARG] B:15 [G] 4.09 59.01
A:176 [PRO] B:14 [A] 4.15 51.0
A:176 [PRO] B:15 [G] 4.41 51.0
A:177 [VAL] B:14 [A] 3.63 70.09
A:178 [GLY] B:13 [A] 3.75 82.37
A:178 [GLY] B:14 [A] 2.85 sugar:BB 82.37
A:179 [ARG] B:12 [C] 2.96 base:SC, base:SC, base:SC 79.2
A:179 [ARG] B:13 [A] 3.25 79.2
A:179 [ARG] B:14 [A] 4.96 79.2
A:220 [SER] B:8 [U] 4.95 D:23 [A] 80.51
A:221 [ALA] B:8 [U] 4.74 D:23 [A] 65.73
A:266 [LYS] B:16 [U] 4.81 59.65
A:269 [ILE] B:21 [U] 4.44 47.36
A:277 [ARG] B:20 [U] 3.07 69.5
A:277 [ARG] B:21 [U] 3.58 69.5
A:279 [TYR] B:20 [U] 2.96 44.69
A:279 [TYR] B:21 [U] 3.96 44.69
A:280 [ARG] B:16 [U] 4.35 53.49
A:280 [ARG] B:17 [C] 3.28 53.49
A:294 [PHE] B:21 [U] 3.39 base/AA stacks 88.05
A:295 [PRO] B:21 [U] 4.76 40.65
A:308 [VAL] B:21 [U] 4.26 95.39
A:311 [TYR] B:20 [U] 4.29 92.57
A:311 [TYR] B:21 [U] 3.51 92.57
A:312 [PHE] B:21 [U] 3.73 90.23
A:316 [HIS] B:21 [U] 3.03 83.69
A:332 [GLN] B:18 [U] 3.73 58.22
A:336 [HIS] B:21 [U] 2.67 base:SC, sugar:BB 35.87
A:337 [THR] B:20 [U] 3.78 51.17
A:337 [THR] B:21 [U] 3.32 51.17
A:338 [TYR] B:21 [U] 2.57 sugar:BB 60.26
A:339 [LEU] B:21 [U] 3.95 59.67
A:351 [ARG] B:9 [G] 3.69 D:22 [C] 74.43
A:351 [ARG] B:14 [A] 4.94 74.43
A:355 [LYS] D:23 [A] 4.79 B:8 [U] 70.63
A:357 [THR] D:24 [A] 4.36 B:7 [U] 65.23
A:358 [ASP] D:24 [A] 2.94 B:7 [U] sugar:SC 47.97
A:358 [ASP] D:25 [U] 3.6 B:6 [A] 47.97
A:361 [THR] D:24 [A] 3.69 B:7 [U] 77.12
A:361 [THR] D:25 [U] 3.29 B:6 [A] 77.12
A:362 [SER] D:25 [U] 3.4 B:6 [A] 69.89
A:362 [SER] D:26 [G] 3.21 B:5 [C] 69.89
A:364 [MET] B:7 [U] 4.99 D:24 [A] 80.72
A:365 [ILE] B:6 [A] 4.93 D:25 [U] 86.38
A:365 [ILE] B:7 [U] 3.56 D:24 [A] 86.38
A:365 [ILE] D:25 [U] 3.43 B:6 [A] 86.38
A:365 [ILE] D:26 [G] 3.95 B:5 [C] 86.38
A:368 [THR] B:7 [U] 4.61 D:24 [A] 78.92
A:375 [ARG] B:7 [U] 4.62 D:24 [A] 97.75
A:434 [VAL] D:30 [G] 3.96 50.06
A:435 [TRP] D:30 [G] 4.67 83.45
A:436 [ASP] D:30 [G] 4.85 84.07
A:438 [ARG] D:30 [G] 4.94 60.07
A:522 [LEU] B:1 [U] 3.41 75.35
A:524 [GLY] B:1 [U] 2.89 base:BB 25.51
A:525 [LYS] B:1 [U] 3.46 48.09
A:525 [LYS] D:23 [A] 3.21 B:8 [U] 48.09
A:525 [LYS] D:24 [A] 2.89 B:7 [U] 48.09
A:526 [THR] B:1 [U] 2.97 base:BB 46.97
A:529 [TYR] B:1 [U] 2.66 base/AA stacks 91.32
A:533 [LYS] B:1 [U] 2.72 99.0
A:544 [THR] B:1 [U] 3.73 93.85
A:545 [GLN] B:1 [U] 2.85 98.52
A:545 [GLN] B:2 [U] 4.62 D:29 [A] 98.52
A:546 [CYS] B:1 [U] 2.9 88.9
A:546 [CYS] B:2 [U] 4.04 D:29 [A] 88.9
A:547 [VAL] B:1 [U] 3.85 77.66
A:547 [VAL] B:2 [U] 3.7 D:29 [A] 77.66
A:548 [GLN] B:1 [U] 3.15 sugar:SC 38.53
A:548 [GLN] B:2 [U] 2.93 D:29 [A] 38.53
A:551 [ASN] B:1 [U] 4.98 79.7
A:551 [ASN] B:2 [U] 2.83 D:29 [A] 79.7
A:558 [GLN] B:2 [U] 4.36 D:29 [A] 77.38
A:558 [GLN] D:29 [A] 2.89 B:2 [U] sugar:SC base/AA stacks 77.38
A:558 [GLN] D:30 [G] 4.48 77.38
A:559 [THR] B:2 [U] 3.25 D:29 [A] 72.86
A:559 [THR] D:29 [A] 4.23 B:2 [U] 72.86
A:562 [ASN] B:2 [U] 2.97 D:29 [A] base:SC 98.76
A:562 [ASN] B:3 [C] 3.85 D:28 [G] 98.76
A:562 [ASN] D:29 [A] 3.73 B:2 [U] 98.76
A:563 [LEU] B:2 [U] 3.5 D:29 [A] 80.94
A:566 [LYS] B:1 [U] 2.72 98.87
A:566 [LYS] B:2 [U] 3.29 D:29 [A] 98.87
A:566 [LYS] B:3 [C] 2.74 D:28 [G] 98.87
A:570 [LYS] B:1 [U] 3.14 98.97
A:598 [VAL] B:10 [C] 3.79 95.12
A:599 [THR] B:10 [C] 3.52 82.95
A:600 [HIS] B:10 [C] 2.95 base:BB 98.89
A:600 [HIS] B:11 [C] 3.07 98.89
A:601 [PRO] B:10 [C] 3.24 85.5
A:601 [PRO] B:11 [C] 4.78 85.5
A:602 [PRO] B:9 [G] 3.47 D:22 [C] 65.07
A:602 [PRO] B:10 [C] 4.21 65.07
A:603 [ALA] B:9 [G] 3.05 D:22 [C] sugar:BB 71.86
A:603 [ALA] B:10 [C] 3.49 71.86
A:635 [ARG] B:10 [C] 3.76 79.77
A:635 [ARG] B:11 [C] 2.82 79.77
A:637 [GLU] B:11 [C] 3.1 sugar:SC 95.44
A:670 [GLY] B:11 [C] 4.06 98.18
A:671 [VAL] B:11 [C] 4.3 95.63
A:672 [SER] B:11 [C] 2.8 base:BB, base:SC 95.49
A:672 [SER] B:12 [C] 3.29 95.49
A:674 [GLY] B:12 [C] 3.85 90.29
A:675 [GLN] B:11 [C] 2.79 sugar:SC 91.35
A:675 [GLN] B:12 [C] 3.44 91.35
A:709 [LYS] B:5 [C] 4.89 D:26 [G] 98.97
A:709 [LYS] B:6 [A] 2.77 D:25 [U] 98.97
A:710 [ARG] B:8 [U] 3.43 D:23 [A] 95.04
A:710 [ARG] B:9 [G] 3.03 D:22 [C] base:SC, base:SC 95.04
A:710 [ARG] B:10 [C] 3.76 95.04
A:710 [ARG] D:22 [C] 4.68 B:9 [G] 95.04
A:714 [ARG] B:7 [U] 4.04 D:24 [A] 98.2
A:726 [LYS] D:27 [U] 3.27 B:4 [A] 75.07
A:726 [LYS] D:28 [G] 3.14 B:3 [C] 75.07
A:753 [HIS] B:5 [C] 3.23 D:26 [G] 94.22
A:753 [HIS] B:6 [A] 2.85 D:25 [U] 94.22
A:754 [ALA] B:5 [C] 3.91 D:26 [G] 63.69
A:755 [GLY] B:5 [C] 3.92 D:26 [G] 86.03
A:756 [ILE] B:4 [A] 4.48 D:27 [U] 82.9
A:756 [ILE] B:5 [C] 3.0 D:26 [G] sugar:BB 82.9
A:756 [ILE] D:27 [U] 3.42 B:4 [A] 82.9
A:756 [ILE] D:28 [G] 3.8 B:3 [C] 82.9
A:757 [GLN] B:5 [C] 3.62 D:26 [G] 82.73
A:757 [GLN] B:6 [A] 3.08 D:25 [U] sugar:SC 82.73
A:757 [GLN] D:26 [G] 3.26 B:5 [C] base:SC 82.73
A:757 [GLN] D:27 [U] 3.67 B:4 [A] 82.73
A:758 [GLY] B:6 [A] 4.22 D:25 [U] 98.81
A:759 [THR] B:6 [A] 3.49 D:25 [U] 99.0
A:759 [THR] B:7 [U] 4.36 D:24 [A] 99.0
A:760 [SER] B:5 [C] 4.92 D:26 [G] 93.87
A:760 [SER] B:6 [A] 3.45 D:25 [U] 93.87
A:761 [ARG] B:6 [A] 2.82 D:25 [U] 90.6
A:761 [ARG] B:7 [U] 2.81 D:24 [A] 90.6
A:761 [ARG] B:8 [U] 2.92 D:23 [A] 90.6
A:790 [TYR] B:3 [C] 4.41 D:28 [G] 78.68
A:790 [TYR] B:4 [A] 2.61 D:27 [U] 78.68
A:792 [ARG] B:3 [C] 3.52 D:28 [G] 97.22
A:792 [ARG] B:4 [A] 2.96 D:27 [U] 97.22
A:793 [CYS] B:3 [C] 3.15 D:28 [G] 83.66
A:793 [CYS] B:4 [A] 3.73 D:27 [U] 83.66
A:795 [ARG] B:4 [A] 3.06 D:27 [U] sugar:SC 89.43
A:797 [VAL] B:4 [A] 3.76 D:27 [U] 95.25
A:797 [VAL] B:5 [C] 3.75 D:26 [G] 95.25
A:798 [SER] B:4 [A] 4.77 D:27 [U] 98.87
A:798 [SER] B:5 [C] 2.73 D:26 [G] 98.87
A:798 [SER] B:6 [A] 4.5 D:25 [U] 98.87
A:799 [ILE] B:5 [C] 4.9 D:26 [G] 80.37
A:804 [TYR] B:4 [A] 3.63 D:27 [U] 83.3
A:804 [TYR] B:5 [C] 2.69 D:26 [G] 83.3
A:811 [PHE] B:10 [C] 3.98 40.36
A:811 [PHE] D:22 [C] 3.22 B:9 [G] base/AA stacks 40.36
A:812 [ARG] B:1 [U] 3.55 95.6
A:815 [TYR] B:1 [U] 3.99 1.83
A:815 [TYR] D:22 [C] 3.35 B:9 [G] 1.83
A:815 [TYR] D:23 [A] 2.72 B:8 [U] 1.83
A:859 [ALA] B:1 [U] 4.03 69.54
A:859 [ALA] B:3 [C] 4.52 D:28 [G] 69.54

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 4Z4D_A_B,D A: Protein argonaute-2, Homo sapiens (genetically engineered) B: Synthetic construct (synthetic) D: Synthetic construct (synthetic) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4Z4D_A_B,D 5I4A_A_B 0.39 0.78 3.14 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRE_A_R 4Z4D_A_B,D 0.86 0.94 2.2 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6OZP_B_C,D 0.48 0.63 2.69 0.1 Ribonuclease H-like compare
4Z4D_A_B,D 6D92_A_C 0.59 0.71 4.22 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6OZS_B_C,D 0.49 0.63 2.83 0.14 Ribonuclease H-like compare
4F3T_A_R 4Z4D_A_B,D 0.70 0.92 3.19 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6OZP_A_C,D 0.56 0.61 2.76 0.15 Ribonuclease H-like compare
4Z4D_A_B,D 6OZS_A_C,D 0.58 0.6 2.77 0.15 Ribonuclease H-like compare
4KXT_A_B 4Z4D_A_B,D 0.87 0.91 2.97 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4Z4D_A_B,D 5AWH_A_C 0.59 0.71 4.13 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4OLA_A_B 4Z4D_A_B,D 0.95 0.93 3.04 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 4Z4D_A_B,D 0.88 0.93 2.36 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6OON_A_B 0.90 0.96 1.83 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 5JS1_A_B 0.90 0.92 3.21 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6MFN_A_C,E 0.85 0.92 1.69 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5T_A_B,D 4Z4D_A_B,D 0.91 0.99 0.27 0.88 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6CBD_A_B,C 0.95 1.0 0.3 0.93 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4Z4D_A_B,D 0.96 1.0 0.12 0.96 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare