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All interfaces > All interologs > Interface groups > group140 > 5JS1_A_B

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Licorice
Surface

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Licorice
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Chain
Chain (with hetatm)
Chainbow
Hydrophobicity
Electrostatics (surface only)
Conservation*

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Rim - Core

Contacts -

5JS1_A
5JS1_B
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:177 [VAL] B:9 [A] 4.67 73.48
A:219 [VAL] B:8 [U] 4.2 65.75
A:220 [SER] B:7 [A] 4.59 78.28
A:220 [SER] B:8 [U] 3.1 78.28
A:221 [ALA] B:7 [A] 3.11 sugar:BB 65.7
A:221 [ALA] B:8 [U] 3.28 65.7
A:222 [THR] B:7 [A] 4.92 75.77
A:222 [THR] B:8 [U] 3.49 75.77
A:222 [THR] B:9 [A] 4.55 75.77
A:223 [ALA] B:8 [U] 4.87 77.94
A:271 [HIS] B:21 [A] 3.82 85.56
A:294 [PHE] B:21 [A] 3.41 90.95
A:296 [LEU] B:21 [A] 4.73 12.18
A:308 [VAL] B:21 [A] 4.65 95.07
A:311 [TYR] B:21 [A] 3.02 base/AA stacks 91.75
A:312 [PHE] B:21 [A] 3.64 90.54
A:315 [ARG] B:21 [A] 4.66 46.56
A:316 [HIS] B:21 [A] 2.68 83.76
A:336 [HIS] B:21 [A] 3.31 sugar:BB 32.41
A:337 [THR] B:21 [A] 3.15 49.92
A:338 [TYR] B:21 [A] 2.6 sugar:BB 63.87
A:339 [LEU] B:21 [A] 4.38 60.85
A:351 [ARG] B:9 [A] 3.47 71.21
A:352 [CYS] B:8 [U] 4.99 53.75
A:353 [ILE] B:9 [A] 4.57 55.15
A:356 [LEU] B:7 [A] 4.34 81.96
A:361 [THR] B:7 [A] 3.46 69.71
A:364 [MET] B:7 [A] 3.41 78.84
A:364 [MET] B:8 [U] 3.65 78.84
A:365 [ILE] B:6 [U] 3.53 82.47
A:365 [ILE] B:7 [A] 3.32 82.47
A:368 [THR] B:7 [A] 2.81 sugar:SC 79.09
A:369 [ALA] B:6 [U] 4.34 76.6
A:369 [ALA] B:7 [A] 4.85 76.6
A:375 [ARG] B:7 [A] 3.87 97.9
A:522 [LEU] B:1 [U] 3.49 76.1
A:524 [GLY] B:1 [U] 3.03 base:BB 25.89
A:525 [LYS] B:1 [U] 3.74 56.29
A:526 [THR] B:1 [U] 3.17 base:BB 48.03
A:529 [TYR] B:1 [U] 2.56 base/AA stacks 88.82
A:533 [LYS] B:1 [U] 3.0 98.97
A:544 [THR] B:1 [U] 3.69 93.88
A:545 [GLN] B:1 [U] 2.94 98.46
A:545 [GLN] B:2 [U] 4.83 98.46
A:546 [CYS] B:1 [U] 2.83 90.46
A:546 [CYS] B:2 [U] 4.03 90.46
A:547 [VAL] B:1 [U] 3.71 79.08
A:547 [VAL] B:2 [U] 3.56 79.08
A:548 [GLN] B:1 [U] 3.17 43.01
A:548 [GLN] B:2 [U] 3.06 43.01
A:551 [ASN] B:2 [U] 2.98 78.25
A:558 [GLN] B:2 [U] 4.35 73.62
A:559 [THR] B:2 [U] 3.51 70.74
A:562 [ASN] B:2 [U] 2.86 base:SC 98.97
A:562 [ASN] B:3 [A] 4.48 98.97
A:563 [LEU] B:2 [U] 3.52 75.12
A:566 [LYS] B:1 [U] 2.9 98.97
A:566 [LYS] B:2 [U] 3.18 98.97
A:566 [LYS] B:3 [A] 3.01 98.97
A:570 [LYS] B:1 [U] 3.44 98.97
A:709 [LYS] B:5 [C] 4.83 99.0
A:709 [LYS] B:6 [U] 2.82 99.0
A:710 [ARG] B:9 [A] 3.9 base/AA stacks 94.93
A:712 [HIS] B:8 [U] 3.76 89.95
A:714 [ARG] B:6 [U] 4.83 98.06
A:714 [ARG] B:7 [A] 2.52 98.06
A:714 [ARG] B:8 [U] 4.96 98.06
A:753 [HIS] B:5 [C] 3.26 95.2
A:753 [HIS] B:6 [U] 2.81 95.2
A:754 [ALA] B:5 [C] 4.13 66.97
A:755 [GLY] B:5 [C] 4.63 83.34
A:756 [ILE] B:4 [U] 2.98 82.32
A:756 [ILE] B:5 [C] 3.64 sugar:BB 82.32
A:757 [GLN] B:5 [C] 3.65 81.83
A:757 [GLN] B:6 [U] 3.26 81.83
A:758 [GLY] B:6 [U] 4.49 98.81
A:759 [THR] B:6 [U] 3.52 99.0
A:759 [THR] B:7 [A] 3.78 99.0
A:760 [SER] B:5 [C] 4.86 92.64
A:760 [SER] B:6 [U] 3.51 92.64
A:761 [ARG] B:5 [C] 4.97 92.27
A:761 [ARG] B:6 [U] 2.73 92.27
A:761 [ARG] B:7 [A] 2.71 92.27
A:761 [ARG] B:8 [U] 2.67 92.27
A:790 [TYR] B:3 [A] 4.29 78.95
A:790 [TYR] B:4 [U] 2.77 78.95
A:792 [ARG] B:3 [A] 3.51 95.71
A:792 [ARG] B:4 [U] 2.99 95.71
A:793 [CYS] B:3 [A] 3.73 85.05
A:793 [CYS] B:4 [U] 3.69 85.05
A:795 [ARG] B:4 [U] 3.09 base:SC 90.49
A:797 [VAL] B:4 [U] 3.64 94.91
A:797 [VAL] B:5 [C] 3.7 94.91
A:798 [SER] B:4 [U] 4.5 98.84
A:798 [SER] B:5 [C] 2.72 98.84
A:798 [SER] B:6 [U] 4.73 98.84
A:799 [ILE] B:5 [C] 4.69 78.56
A:804 [TYR] B:4 [U] 3.66 80.39
A:804 [TYR] B:5 [C] 2.77 80.39
A:812 [ARG] B:1 [U] 3.37 95.58
A:815 [TYR] B:1 [U] 4.81 0.43
A:859 [ALA] B:1 [U] 4.44 69.54
A:859 [ALA] B:3 [A] 4.53 69.54

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 5JS1_A_B A: Protein argonaute-2, Homo sapiens (genetically engineered) B: siRNA, Synthetic construct (synthetic) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 18

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 5JS1_A_B 0.99 1.0 0.31 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KXT_A_B 5JS1_A_B 0.97 0.98 0.84 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KRE_A_R 5JS1_A_B 0.98 0.97 1.31 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
5JS1_A_B 6MFN_A_C,E 0.86 0.86 1.83 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
5JS1_A_B 6OZS_B_C,D 0.52 0.61 2.68 0.0 Ribonuclease H-like compare
5JS1_A_B 6OZS_A_C,D 0.58 0.61 2.63 0.0 Ribonuclease H-like compare
5JS1_A_B 6D92_A_C 0.60 0.71 3.43 0.15 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
5JS1_A_B 6CBD_A_B,C 0.91 0.91 3.24 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
5JS1_A_B 6OON_A_B 0.98 0.96 1.74 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
5JS1_A_B 6OZP_B_C,D 0.50 0.61 2.67 0.05 Ribonuclease H-like compare
5JS1_A_B 6OZP_A_C,D 0.58 0.61 2.68 0.1 Ribonuclease H-like compare
5AWH_A_C 5JS1_A_B 0.62 0.71 4.1 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 5JS1_A_B 0.90 0.92 3.21 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 5JS1_A_B 0.88 0.92 3.24 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4KRF_A_R 5JS1_A_B 0.98 0.98 1.05 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 5JS1_A_B 0.87 0.92 3.34 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
5I4A_A_B 5JS1_A_B 0.60 0.77 3.53 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 5JS1_A_B 0.98 0.99 0.4 0.3 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare