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All interfaces > All interologs > Interface groups > group140 > 6MFN_A_C,E

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Licorice
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Licorice
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Chain
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Hydrophobicity
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Conservation*

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Rim - Core

Contacts -

6MFN_A
6MFN_C,E
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:177 [VAL] C:9 [G] 4.2 69.23
A:220 [SER] C:8 [U] 3.74 E:22 [U] 79.35
A:221 [ALA] C:8 [U] 4.23 E:22 [U] 63.63
A:351 [ARG] C:9 [G] 4.57 74.16
A:355 [LYS] E:23 [C] 4.48 C:7 [G] 66.72
A:361 [THR] E:24 [U] 3.45 C:6 [A] 71.83
A:365 [ILE] E:24 [U] 4.6 C:6 [A] 82.63
A:365 [ILE] E:25 [G] 3.75 C:5 [C] 82.63
A:368 [THR] C:7 [G] 3.06 E:23 [C] sugar:SC 80.4
A:368 [THR] C:8 [U] 4.14 E:22 [U] 80.4
A:369 [ALA] C:6 [A] 4.05 E:24 [U] 75.61
A:369 [ALA] C:7 [G] 4.51 E:23 [C] 75.61
A:375 [ARG] C:7 [G] 4.41 E:23 [C] 97.43
A:522 [LEU] C:1 [U] 3.27 75.18
A:524 [GLY] C:1 [U] 3.12 base:BB 32.22
A:525 [LYS] C:1 [U] 3.5 49.39
A:525 [LYS] E:22 [U] 4.54 C:8 [U] 49.39
A:525 [LYS] E:23 [C] 2.79 C:7 [G] 49.39
A:526 [THR] C:1 [U] 3.34 base:BB 43.78
A:529 [TYR] C:1 [U] 2.57 base/AA stacks 88.44
A:533 [LYS] C:1 [U] 2.98 98.95
A:544 [THR] C:1 [U] 3.97 95.23
A:545 [GLN] C:1 [U] 3.19 98.18
A:545 [GLN] C:2 [U] 4.69 E:28 [A] 98.18
A:546 [CYS] C:1 [U] 2.73 90.78
A:546 [CYS] C:2 [U] 3.89 E:28 [A] 90.78
A:547 [VAL] C:1 [U] 3.96 77.19
A:547 [VAL] C:2 [U] 3.81 E:28 [A] 77.19
A:548 [GLN] C:1 [U] 3.43 39.44
A:548 [GLN] C:2 [U] 2.9 E:28 [A] 39.44
A:551 [ASN] C:1 [U] 4.77 75.8
A:551 [ASN] C:2 [U] 2.47 E:28 [A] 75.8
A:558 [GLN] C:2 [U] 4.53 E:28 [A] 71.14
A:558 [GLN] E:28 [A] 3.38 C:2 [U] 71.14
A:558 [GLN] E:29 [U] 4.35 71.14
A:559 [THR] C:2 [U] 3.49 E:28 [A] 75.87
A:559 [THR] E:28 [A] 4.58 C:2 [U] 75.87
A:562 [ASN] C:2 [U] 3.04 E:28 [A] base:SC 98.92
A:562 [ASN] C:3 [C] 4.05 E:27 [G] 98.92
A:562 [ASN] E:28 [A] 3.89 C:2 [U] 98.92
A:563 [LEU] C:2 [U] 3.48 E:28 [A] 77.68
A:566 [LYS] C:1 [U] 2.34 98.89
A:566 [LYS] C:2 [U] 3.19 E:28 [A] 98.89
A:566 [LYS] C:3 [C] 3.11 E:27 [G] 98.89
A:570 [LYS] C:1 [U] 2.67 98.84
A:709 [LYS] C:6 [A] 4.44 E:24 [U] 98.92
A:710 [ARG] C:8 [U] 4.96 E:22 [U] 94.27
A:714 [ARG] C:6 [A] 4.51 E:24 [U] 96.2
A:714 [ARG] C:7 [G] 2.63 E:23 [C] 96.2
A:726 [LYS] E:26 [U] 4.28 C:4 [A] 74.71
A:726 [LYS] E:27 [G] 4.12 C:3 [C] 74.71
A:753 [HIS] C:5 [C] 3.17 E:25 [G] 94.99
A:753 [HIS] C:6 [A] 2.77 E:24 [U] 94.99
A:754 [ALA] C:5 [C] 4.32 E:25 [G] 67.0
A:755 [GLY] C:5 [C] 4.3 E:25 [G] 83.25
A:756 [ILE] C:4 [A] 3.51 E:26 [U] 80.59
A:756 [ILE] C:5 [C] 3.4 E:25 [G] sugar:BB 80.59
A:756 [ILE] E:26 [U] 4.79 C:4 [A] 80.59
A:756 [ILE] E:27 [G] 4.31 C:3 [C] 80.59
A:757 [GLN] C:4 [A] 4.82 E:26 [U] 81.92
A:757 [GLN] C:5 [C] 3.4 E:25 [G] base:SC 81.92
A:757 [GLN] C:6 [A] 3.36 E:24 [U] 81.92
A:757 [GLN] E:25 [G] 3.9 C:5 [C] 81.92
A:757 [GLN] E:26 [U] 2.51 C:4 [A] base:SC, sugar:SC 81.92
A:757 [GLN] E:27 [G] 3.15 C:3 [C] sugar:SC 81.92
A:758 [GLY] C:6 [A] 4.35 E:24 [U] 98.4
A:758 [GLY] C:7 [G] 4.33 E:23 [C] 98.4
A:759 [THR] C:6 [A] 3.52 E:24 [U] 98.95
A:759 [THR] C:7 [G] 3.95 E:23 [C] 98.95
A:760 [SER] C:6 [A] 3.63 E:24 [U] 91.44
A:761 [ARG] C:6 [A] 2.76 E:24 [U] 90.01
A:761 [ARG] C:7 [G] 3.8 E:23 [C] 90.01
A:761 [ARG] C:8 [U] 4.86 E:22 [U] 90.01
A:790 [TYR] C:3 [C] 4.44 E:27 [G] 75.84
A:790 [TYR] C:4 [A] 2.72 E:26 [U] 75.84
A:792 [ARG] C:3 [C] 3.33 E:27 [G] 94.77
A:792 [ARG] C:4 [A] 2.7 E:26 [U] 94.77
A:793 [CYS] C:3 [C] 3.3 E:27 [G] 82.65
A:793 [CYS] C:4 [A] 3.67 E:26 [U] 82.65
A:795 [ARG] C:4 [A] 3.38 E:26 [U] sugar:SC 87.89
A:797 [VAL] C:4 [A] 3.77 E:26 [U] 93.8
A:797 [VAL] C:5 [C] 3.74 E:25 [G] 93.8
A:798 [SER] C:4 [A] 4.83 E:26 [U] 97.74
A:798 [SER] C:5 [C] 2.64 E:25 [G] 97.74
A:798 [SER] C:6 [A] 4.8 E:24 [U] 97.74
A:799 [ILE] C:5 [C] 4.88 E:25 [G] 77.5
A:804 [TYR] C:4 [A] 3.56 E:26 [U] 76.66
A:804 [TYR] C:5 [C] 2.53 E:25 [G] 76.66
A:811 [PHE] E:22 [U] 3.96 C:8 [U] 24.85
A:812 [ARG] C:1 [U] 3.62 94.79
A:814 [ARG] E:22 [U] 4.3 C:8 [U] 83.32
A:815 [TYR] C:1 [U] 4.45 0.25
A:815 [TYR] E:22 [U] 4.29 C:8 [U] 0.25
A:859 [ALA] C:1 [U] 3.84 69.54
A:859 [ALA] C:3 [C] 4.77 E:27 [G] 69.54

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group140 6MFN_A_C,E A: Protein argonaute-2, Homo sapiens (genetically engineered) C: Homo sapiens (synthetic) E: Synthetic construct (synthetic) Q9UKV8 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs ✘

Interologs

Total number of interologs for this interface: 17

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 6MFN_A_C,E 0.88 0.86 1.81 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6MFN_A_C,E 6OZP_A_C,D 0.59 0.61 2.53 0.1 Ribonuclease H-like compare
6MFN_A_C,E 6OON_A_B 0.88 0.89 1.67 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6MFN_A_C,E 6OZP_B_C,D 0.47 0.63 2.56 0.05 Ribonuclease H-like compare
6MFN_A_C,E 6OZS_A_C,D 0.59 0.61 2.51 0.1 Ribonuclease H-like compare
6MFN_A_C,E 6OZS_B_C,D 0.42 0.63 2.57 0.09 Ribonuclease H-like compare
4KXT_A_B 6MFN_A_C,E 0.90 0.85 1.72 0.17 Ribonuclease H-like & Argonaute, N-terminal domain compare
4KRE_A_R 6MFN_A_C,E 0.86 0.87 1.83 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6D92_A_C 6MFN_A_C,E 0.65 0.7 2.72 0.12 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
5JS1_A_B 6MFN_A_C,E 0.86 0.86 1.83 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
5AWH_A_C 6MFN_A_C,E 0.67 0.7 2.74 0.18 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6MFN_A_C,E 0.85 0.92 1.69 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6MFN_A_C,E 0.85 0.92 1.55 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4KRF_A_R 6MFN_A_C,E 0.87 0.86 1.85 0.08 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6MFN_A_C,E 0.83 0.93 1.53 0.59 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4F3T_A_R 6MFN_A_C,E 0.84 0.85 1.9 0.21 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6CBD_A_B,C 6MFN_A_C,E 0.83 0.92 1.43 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare