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All interfaces > All interologs > Interface groups > group141 > 5TF6_A_B

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Licorice
Surface

RNA

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Licorice
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Chain
Chain (with hetatm)
Chainbow
Hydrophobicity
Electrostatics (surface only)
Conservation*

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Rim - Core

Contacts -

5TF6_A
5TF6_B
Distance
Base Pair
Hbond nuc:res
Base Stacking
Residue conservation
A:33 [MET] B:52 [G] 4.99 70.51
A:35 [THR] B:52 [G] 2.94 72.98
A:35 [THR] B:53 [A] 4.96 72.98
A:36 [ARG] B:52 [G] 2.99 base/AA stacks 86.53
A:37 [ASN] B:52 [G] 4.86 83.55
A:38 [ARG] B:50 [G] 3.2 base/AA stacks 98.93
A:38 [ARG] B:52 [G] 2.84 base:SC, base:SC 98.93
A:118 [THR] B:50 [G] 4.19 98.98
A:120 [TRP] B:48 [C] 3.55 67.94
A:120 [TRP] B:49 [A] 3.14 sugar:SC base/AA stacks 67.94
A:122 [THR] B:47 [A] 3.05 sugar:SC 96.44
A:122 [THR] B:48 [C] 3.37 96.44
A:123 [ASN] B:46 [U] 2.79 base:SC 98.93
A:123 [ASN] B:47 [A] 3.18 sugar:BB 98.93
A:124 [PHE] B:47 [A] 4.84 81.74
A:148 [ARG] B:50 [G] 2.85 base:SC, base:SC 98.93
A:149 [LEU] B:51 [A] 4.61 72.08
A:150 [PRO] B:50 [G] 4.1 98.73
A:150 [PRO] B:51 [A] 3.56 98.73
A:151 [SER] B:50 [G] 4.71 98.86
A:151 [SER] B:51 [A] 2.89 98.86
A:151 [SER] B:53 [A] 3.43 98.86
A:153 [ARG] B:53 [A] 4.19 84.04
A:153 [ARG] B:57 [U] 4.52 84.04
A:153 [ARG] B:58 [C] 2.8 base:SC, base:SC 84.04
A:154 [PHE] B:53 [A] 3.75 50.57
A:154 [PHE] B:54 [U] 3.21 base/AA stacks 50.57
A:154 [PHE] B:57 [U] 2.8 base:BB 50.57
A:154 [PHE] B:58 [C] 3.69 50.57
A:155 [ASN] B:57 [U] 4.99 94.23
A:157 [SER] B:47 [A] 3.79 73.87
A:157 [SER] B:48 [C] 4.13 73.87
A:158 [ARG] B:47 [A] 4.38 98.76
A:158 [ARG] B:48 [C] 3.27 98.76
A:158 [ARG] B:50 [G] 3.17 98.76
A:158 [ARG] B:51 [A] 2.77 98.76
A:158 [ARG] B:53 [A] 3.22 98.76
A:159 [ARG] B:46 [U] 2.87 base:SC 98.93
A:159 [ARG] B:47 [A] 2.89 sugar:BB 98.93
A:159 [ARG] B:48 [C] 2.8 98.93
A:160 [PHE] B:48 [C] 3.36 98.61
A:160 [PHE] B:49 [A] 3.68 98.61
A:160 [PHE] B:50 [G] 3.6 98.61
A:162 [TYR] B:49 [A] 2.84 base:SC 97.94
A:162 [TYR] B:50 [G] 3.14 base/AA stacks 97.94
A:186 [TYR] B:46 [U] 3.55 54.88
A:189 [VAL] B:47 [A] 4.37 79.35
A:191 [LYS] B:49 [A] 3.67 80.21
A:192 [VAL] B:49 [A] 4.35 77.62
A:193 [SER] B:49 [A] 3.43 99.0
A:193 [SER] B:50 [G] 4.68 99.0
A:194 [ASN] B:49 [A] 2.94 base:BB 81.76
A:195 [PRO] B:49 [A] 3.36 92.37
A:195 [PRO] B:50 [G] 3.77 92.37
A:195 [PRO] B:52 [G] 4.09 92.37
A:197 [GLU] B:49 [A] 4.67 23.05
A:198 [LYS] B:49 [A] 3.31 79.73
A:199 [SER] B:48 [C] 4.05 50.75
A:199 [SER] B:49 [A] 4.31 50.75
A:200 [LYS] B:48 [C] 3.65 33.25
A:201 [ARG] B:47 [A] 3.99 98.4
A:201 [ARG] B:48 [C] 3.02 base/AA stacks 98.4
A:201 [ARG] B:49 [A] 2.84 98.4
A:202 [THR] B:45 [A] 3.44 71.42
A:202 [THR] B:47 [A] 3.82 71.42
A:202 [THR] B:48 [C] 2.74 base:BB, base:SC 71.42
A:203 [ASP] B:44 [A] 3.61 84.39
A:203 [ASP] B:47 [A] 4.3 84.39
A:203 [ASP] B:48 [C] 3.81 84.39
A:206 [THR] B:43 [C] 3.9 27.78
A:206 [THR] B:44 [A] 3.19 27.78
A:211 [GLU] B:43 [C] 2.61 base:SC, base:SC 95.12
A:211 [GLU] B:44 [A] 4.09 95.12
A:213 [MET] B:41 [A] 3.9 49.86
A:213 [MET] B:42 [A] 3.46 49.86
A:215 [ARG] B:41 [A] 3.44 62.74
A:215 [ARG] B:91 [A] 3.33 B:40 [A] base/AA stacks 62.74
A:216 [ASN] B:39 [G] 4.18 B:92 [C] 84.29
A:216 [ASN] B:40 [A] 3.16 B:91 [A] base:SC 84.29
A:216 [ASN] B:91 [A] 3.65 B:40 [A] 84.29
A:216 [ASN] B:92 [C] 2.78 B:39 [G] base:SC 84.29
A:239 [LYS] B:44 [A] 3.5 39.18
A:239 [LYS] B:45 [A] 4.99 39.18
A:241 [ASN] B:43 [C] 3.07 base:SC 55.47
A:241 [ASN] B:44 [A] 3.45 55.47
A:242 [ILE] B:43 [C] 4.03 71.83
A:243 [PRO] B:41 [A] 3.78 83.18
A:243 [PRO] B:42 [A] 4.23 83.18
A:243 [PRO] B:43 [C] 3.57 83.18
A:244 [ALA] B:41 [A] 4.61 46.76
A:246 [GLN] B:41 [A] 3.33 15.72
A:250 [SER] B:40 [A] 4.77 B:91 [A] 48.58
A:251 [PHE] B:40 [A] 3.25 B:91 [A] 51.84
A:251 [PHE] B:41 [A] 3.37 51.84
A:252 [ASN] B:39 [G] 2.94 B:92 [C] sugar:SC 73.79
A:252 [ASN] B:40 [A] 2.95 B:91 [A] 73.79
A:253 [ASN] B:39 [G] 3.46 B:92 [C] 65.61
A:253 [ASN] B:40 [A] 2.91 B:91 [A] base:SC 65.61
A:253 [ASN] B:41 [A] 3.22 65.61
A:254 [CYS] B:41 [A] 3.96 87.28
A:255 [CYS] B:41 [A] 3.63 51.47
A:255 [CYS] B:42 [A] 4.54 51.47
A:257 [PHE] B:42 [A] 3.3 87.45
A:257 [PHE] B:43 [C] 3.25 base/AA stacks 87.45
A:273 [ASN] B:91 [A] 3.88 B:40 [A] sugar:SC 76.31
A:274 [ARG] B:91 [A] 3.44 B:40 [A] 39.36
A:274 [ARG] B:92 [C] 3.05 B:39 [G] 39.36
A:281 [GLU] B:92 [C] 3.72 B:39 [G] 19.67
A:283 [SER] B:91 [A] 2.68 B:40 [A] base:SC 37.32
A:283 [SER] B:92 [C] 4.21 B:39 [G] 37.32
A:287 [ALA] B:42 [A] 4.03 86.53
A:287 [ALA] B:43 [C] 4.57 86.53
A:287 [ALA] B:55 [G] 4.85 86.53
A:288 [ASP] B:42 [A] 3.05 base:SC, base:BB 56.64
A:288 [ASP] B:43 [C] 4.78 56.64
A:288 [ASP] B:55 [G] 2.68 base:SC 56.64
A:289 [LYS] B:55 [G] 2.66 base:BB 36.82
A:290 [LYS] B:42 [A] 2.72 sugar:SC 66.18
A:290 [LYS] B:43 [C] 2.46 66.18
A:290 [LYS] B:44 [A] 3.71 66.18
A:291 [PRO] B:57 [U] 3.37 58.96
A:292 [PHE] B:55 [G] 3.33 base/AA stacks 44.6
A:292 [PHE] B:57 [U] 3.3 44.6
A:293 [LEU] B:42 [A] 3.88 72.78
A:295 [ARG] B:57 [U] 3.27 70.15
A:295 [ARG] B:58 [C] 3.02 base/AA stacks 70.15
A:296 [ASN] B:57 [U] 3.61 61.71
A:299 [LYS] B:56 [A] 4.71 55.33
A:299 [LYS] B:57 [U] 4.42 55.33
A:299 [LYS] B:58 [C] 2.76 55.33
A:300 [ARG] B:36 [U] 4.77 B:95 [A] 44.57
A:300 [ARG] B:37 [U] 3.26 B:94 [A] 44.57
A:303 [ALA] B:36 [U] 4.92 B:95 [A] 43.04
A:321 [ASP] B:51 [A] 2.92 base:SC 96.71
A:322 [LYS] B:51 [A] 4.62 91.28
A:350 [SER] B:58 [C] 3.61 80.34
A:351 [ASP] B:58 [C] 3.79 base/AA stacks 77.15
A:398 [GLN] B:82 [A] 4.01 B:65 [U] 70.51
A:398 [GLN] B:83 [A] 4.34 B:64 [U] 70.51

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*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)

Properties of this interface

Interolog group ID Structure ID Structure description
 UniProt ID
 		ECOD label(s)
 		RFAM label(s)
 		Is ribosome? RCSB PDB link
group141 5TF6_A_B A: U4/u6 snRNA-associated-splicing factor prp24, Saccharomyces cerevisiae (genetically engineered) B: U6 snRNA, Saccharomyces cerevisiae (synthetic) P49960 RNA-binding domain, RBD U6 spliceosomal RNA ✘

Interologs

Total number of interologs for this interface: 5

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
5TF6_A_B 6SQN_A_X 0.56 0.63 2.54 0.1 RNA-binding domain, RBD compare
5TF6_A_B 6F4G_B_C 0.58 0.61 3.75 0.0 RNA-binding domain, RBD compare
5TF6_A_B 6F4H_A_B 0.57 0.64 3.83 0.0 RNA-binding domain, RBD compare
4N0T_A_B 5TF6_A_B 0.98 0.95 0.87 0.96 RNA-binding domain, RBD U6 spliceosomal RNA compare
1URN_A_P 5TF6_A_B 0.54 0.62 3.87 0.0 RNA-binding domain, RBD compare