Interface analysis
Style
Protein
CartoonLicorice
Surface
RNA
CartoonLicorice
Surface
Color
ChainChain (with hetatm)
Chainbow
Hydrophobicity Electrostatics (surface only) Conservation*
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InterfaceRNA
Protein
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Interface
show as licoriceshow Accessibility
Rim - Core
Contacts -
| 4S3N_A
|
4S3N_B,C
|
Distance
|
Base Pair
|
Hbond nuc:res
|
Base Stacking
|
Residue conservation
|
|---|---|---|---|---|---|---|
| A:12 [ASP] | C:35 [A] | 3.25 | B:4 [U] | 81.76 | ||
| A:12 [ASP] | C:36 [G] | 3.42 | B:3 [C] | 81.76 | ||
| A:13 [ARG] | C:35 [A] | 4.67 | B:4 [U] | 34.47 | ||
| A:13 [ARG] | C:36 [G] | 3.86 | B:3 [C] | 34.47 | ||
| A:13 [ARG] | C:37 [C] | 3.21 | B:2 [G] | 34.47 | ||
| A:16 [ALA] | C:35 [A] | 3.73 | B:4 [U] | 26.84 | ||
| A:16 [ALA] | C:36 [G] | 4.41 | B:3 [C] | 26.84 | ||
| A:20 [GLN] | B:6 [U] | 4.31 | C:33 [A] | 72.5 | ||
| A:23 [LYS] | B:5 [U] | 4.58 | C:34 [A] | 39.27 | ||
| A:23 [LYS] | B:6 [U] | 3.28 | C:33 [A] | 39.27 | ||
| A:30 [ARG] | C:25 [A] | 3.45 | B:14 [U] | 28.82 | ||
| A:30 [ARG] | C:26 [A] | 3.26 | B:13 [U] | 28.82 | ||
| A:34 [GLY] | C:24 [U] | 4.01 | B:15 [A] | 27.33 | ||
| A:34 [GLY] | C:25 [A] | 4.05 | B:14 [U] | 27.33 | ||
| A:37 [ALA] | C:24 [U] | 4.29 | B:15 [A] | 46.93 | ||
| A:41 [ARG] | B:15 [A] | 4.49 | C:24 [U] | 63.28 | ||
| A:41 [ARG] | B:16 [U] | 2.95 | C:23 [A] | sugar:SC | 63.28 | |
| A:41 [ARG] | B:17 [G] | 3.46 | C:22 [C] | 63.28 | ||
| A:41 [ARG] | C:24 [U] | 3.31 | B:15 [A] | base:SC | 63.28 | |
| A:42 [GLU] | B:16 [U] | 3.13 | C:23 [A] | sugar:SC | 37.52 | |
| A:42 [GLU] | B:17 [G] | 4.12 | C:22 [C] | 37.52 | ||
| A:53 [ARG] | B:18 [A] | 3.5 | C:21 [U] | 48.02 | ||
| A:53 [ARG] | B:19 [A] | 3.22 | C:20 [U] | 48.02 | ||
| A:54 [VAL] | B:17 [G] | 2.67 | C:22 [C] | sugar:BB | 86.34 | |
| A:54 [VAL] | B:18 [A] | 3.39 | C:21 [U] | 86.34 | ||
| A:55 [LEU] | B:17 [G] | 3.16 | C:22 [C] | base:BB | 54.07 | |
| A:55 [LEU] | B:18 [A] | 3.33 | C:21 [U] | 54.07 | ||
| A:55 [LEU] | B:19 [A] | 4.31 | C:20 [U] | 54.07 | ||
| A:55 [LEU] | C:22 [C] | 4.57 | B:17 [G] | 54.07 | ||
| A:56 [LYS] | B:17 [G] | 4.97 | C:22 [C] | 57.63 | ||
| A:56 [LYS] | C:22 [C] | 3.78 | B:17 [G] | 57.63 | ||
| A:56 [LYS] | C:23 [A] | 3.55 | B:16 [U] | 57.63 | ||
| A:57 [THR] | C:23 [A] | 2.65 | B:16 [U] | sugar:BB, sugar:BB | 76.42 | |
| A:57 [THR] | C:24 [U] | 3.15 | B:15 [A] | sugar:BB | 76.42 | |
| A:58 [VAL] | C:23 [A] | 3.94 | B:16 [U] | 67.15 | ||
| A:58 [VAL] | C:24 [U] | 4.27 | B:15 [A] | 67.15 | ||
| A:59 [LYS] | C:24 [U] | 3.81 | B:15 [A] | 80.67 | ||
| A:59 [LYS] | C:25 [A] | 3.43 | B:14 [U] | 80.67 | ||
| A:82 [ASP] | B:19 [A] | 4.64 | C:20 [U] | 64.32 | ||
| A:154 [GLY] | C:22 [C] | 4.72 | B:17 [G] | 80.37 | ||
| A:155 [GLN] | B:18 [A] | 4.32 | C:21 [U] | 31.02 | ||
| A:155 [GLN] | B:19 [A] | 3.45 | C:20 [U] | 31.02 | ||
| A:155 [GLN] | C:21 [U] | 3.01 | B:18 [A] | base:SC, sugar:SC | 31.02 | |
| A:155 [GLN] | C:22 [C] | 3.27 | B:17 [G] | base/AA stacks | 31.02 | |
| A:186 [GLU] | C:22 [C] | 4.82 | B:17 [G] | 75.83 | ||
| A:186 [GLU] | C:23 [A] | 3.6 | B:16 [U] | 75.83 | ||
| A:189 [ARG] | B:8 [G] | 4.71 | C:31 [C] | 61.79 | ||
| A:189 [ARG] | C:24 [U] | 4.31 | B:15 [A] | 61.79 | ||
| A:193 [ASN] | B:7 [U] | 4.13 | C:32 [A] | 55.59 | ||
| A:193 [ASN] | B:8 [G] | 3.21 | C:31 [C] | 55.59 | ||
| A:194 [ILE] | B:8 [G] | 3.91 | C:31 [C] | 31.64 | ||
| A:194 [ILE] | B:9 [A] | 4.03 | C:30 [U] | 31.64 | ||
| A:195 [ARG] | B:7 [U] | 4.48 | C:32 [A] | 64.04 | ||
| A:196 [PRO] | C:33 [A] | 4.86 | B:6 [U] | 88.75 | ||
| A:197 [ALA] | B:6 [U] | 4.58 | C:33 [A] | 54.27 | ||
| A:197 [ALA] | B:7 [U] | 4.59 | C:32 [A] | 54.27 | ||
| A:197 [ALA] | C:33 [A] | 4.13 | B:6 [U] | 54.27 | ||
| A:197 [ALA] | C:34 [A] | 4.15 | B:5 [U] | 54.27 | ||
| A:198 [LYS] | C:34 [A] | 3.55 | B:5 [U] | 85.38 | ||
| A:198 [LYS] | C:35 [A] | 2.88 | B:4 [U] | 85.38 | ||
| A:200 [LYS] | B:7 [U] | 2.8 | C:32 [A] | sugar:SC | 88.11 | |
| A:200 [LYS] | B:8 [G] | 4.11 | C:31 [C] | 88.11 | ||
| A:201 [ASN] | C:34 [A] | 3.76 | B:5 [U] | sugar:SC | 69.76 | |
| A:201 [ASN] | C:35 [A] | 4.73 | B:4 [U] | 69.76 | ||
| A:244 [ASP] | C:33 [A] | 3.14 | B:6 [U] | 52.71 | ||
| A:244 [ASP] | C:34 [A] | 3.24 | B:5 [U] | 52.71 | ||
| A:245 [ALA] | C:34 [A] | 3.59 | B:5 [U] | 46.64 | ||
| A:246 [PHE] | C:35 [A] | 4.95 | B:4 [U] | 90.89 |
Export the table of contacts
*Conservation was calculated using Rate4Site
NB: conservation is missing (completly white) for a very small minority of cases in which no homologous sequences were found (e.g. synthetic proteins 7D3J_A & 7EU9_A)
Properties of this interface
| Interolog group ID | Structure ID |
Structure description |
UniProt ID |
ECOD label(s) |
RFAM label(s) |
Is ribosome? | RCSB PDB link |
|---|---|---|---|---|---|---|---|
| group41 | 4S3N_A_B,C | A: 2'-5'-oligoadenylate synthase 3, Homo sapiens (genetically engineered) B: Synthetic (synthetic) C: Synthetic (synthetic) | Q9Y6K5 | PAP/OAS1 substrate-binding domain & Nucleotidyltransferase | ✘ |
|
Interologs
Total number of interologs for this interface: 2
| Interface 1 | Interface 2 |
Percentage conservation |
Interface TM-score |
Interface RMSD |
Percentage identity |
Common ECOD label(s) |
Common RFAM label(s) |
Explore both interfaces |
|---|---|---|---|---|---|---|---|---|
| 4RWO_A_B,C | 4S3N_A_B,C | 0.81 | 0.89 | 1.07 | 0.42 | PAP/OAS1 substrate-binding domain & Nucleotidyltransferase | compare | |
| 4RWN_A_B,C | 4S3N_A_B,C | 0.80 | 0.9 | 0.98 | 0.42 | PAP/OAS1 substrate-binding domain & Nucleotidyltransferase | compare |