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All interfaces > All interologs > Interface groups > group140 > 4W5O_A_B,D vs 6MFN_A_C,E

Interface analysis


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Common contacts -

4W5O_A
4W5O_B,D
6MFN_A
6MFN_C,E
Conserved?
A:757 [GLN] B:5 [C] A:757 [GLN] C:5 [C] ✔
A:757 [GLN] B:6 [A] A:757 [GLN] C:6 [A] ✔
A:757 [GLN] D:26 [G] A:757 [GLN] E:25 [G] ✔
A:757 [GLN] D:27 [U] A:757 [GLN] E:26 [U] ✔
A:709 [LYS] B:6 [A] A:709 [LYS] C:6 [A] ✔
A:812 [ARG] B:1 [U] A:812 [ARG] C:1 [U] ✔
A:790 [TYR] B:3 [C] A:790 [TYR] C:3 [C] ✔
A:790 [TYR] B:4 [A] A:790 [TYR] C:4 [A] ✔
A:566 [LYS] B:1 [U] A:566 [LYS] C:1 [U] ✔
A:566 [LYS] B:2 [U] A:566 [LYS] C:2 [U] ✔
A:566 [LYS] B:3 [C] A:566 [LYS] C:3 [C] ✔
A:797 [VAL] B:4 [A] A:797 [VAL] C:4 [A] ✔
A:797 [VAL] B:5 [C] A:797 [VAL] C:5 [C] ✔
A:755 [GLY] B:5 [C] A:755 [GLY] C:5 [C] ✔
A:754 [ALA] B:5 [C] A:754 [ALA] C:5 [C] ✔
A:221 [ALA] B:8 [U] A:221 [ALA] C:8 [U] ✔
A:351 [ARG] B:9 [G] A:351 [ARG] C:9 [G] ✔
A:710 [ARG] B:8 [U] A:710 [ARG] C:8 [U] ✔
A:562 [ASN] B:2 [U] A:562 [ASN] C:2 [U] ✔
A:562 [ASN] B:3 [C] A:562 [ASN] C:3 [C] ✔
A:562 [ASN] D:29 [A] A:562 [ASN] E:28 [A] ✔
A:545 [GLN] B:1 [U] A:545 [GLN] C:1 [U] ✔
A:545 [GLN] B:2 [U] A:545 [GLN] C:2 [U] ✔
A:793 [CYS] B:3 [C] A:793 [CYS] C:3 [C] ✔
A:793 [CYS] B:4 [A] A:793 [CYS] C:4 [A] ✔
A:726 [LYS] D:27 [U] A:726 [LYS] E:26 [U] ✔
A:726 [LYS] D:28 [G] A:726 [LYS] E:27 [G] ✔
A:526 [THR] B:1 [U] A:526 [THR] C:1 [U] ✔
A:375 [ARG] B:7 [U] A:375 [ARG] C:7 [G] ✔
A:753 [HIS] B:5 [C] A:753 [HIS] C:5 [C] ✔
A:753 [HIS] B:6 [A] A:753 [HIS] C:6 [A] ✔
A:522 [LEU] B:1 [U] A:522 [LEU] C:1 [U] ✔
A:563 [LEU] B:2 [U] A:563 [LEU] C:2 [U] ✔
A:798 [SER] B:4 [A] A:798 [SER] C:4 [A] ✔
A:798 [SER] B:5 [C] A:798 [SER] C:5 [C] ✔
A:798 [SER] B:6 [A] A:798 [SER] C:6 [A] ✔
A:558 [GLN] B:2 [U] A:558 [GLN] C:2 [U] ✔
A:558 [GLN] D:29 [A] A:558 [GLN] E:28 [A] ✔
A:714 [ARG] B:7 [U] A:714 [ARG] C:7 [G] ✔
A:559 [THR] B:2 [U] A:559 [THR] C:2 [U] ✔
A:559 [THR] D:29 [A] A:559 [THR] E:28 [A] ✔
A:804 [TYR] B:4 [A] A:804 [TYR] C:4 [A] ✔
A:804 [TYR] B:5 [C] A:804 [TYR] C:5 [C] ✔
A:815 [TYR] B:1 [U] A:815 [TYR] C:1 [U] ✔
A:815 [TYR] D:23 [A] A:815 [TYR] E:22 [U] ✔
A:756 [ILE] B:4 [A] A:756 [ILE] C:4 [A] ✔
A:756 [ILE] B:5 [C] A:756 [ILE] C:5 [C] ✔
A:756 [ILE] D:27 [U] A:756 [ILE] E:26 [U] ✔
A:756 [ILE] D:28 [G] A:756 [ILE] E:27 [G] ✔
A:547 [VAL] B:1 [U] A:547 [VAL] C:1 [U] ✔
A:547 [VAL] B:2 [U] A:547 [VAL] C:2 [U] ✔
A:859 [ALA] B:1 [U] A:859 [ALA] C:1 [U] ✔
A:859 [ALA] B:3 [C] A:859 [ALA] C:3 [C] ✔
A:799 [ILE] B:5 [C] A:799 [ILE] C:5 [C] ✔
A:529 [TYR] B:1 [U] A:529 [TYR] C:1 [U] ✔
A:570 [LYS] B:1 [U] A:570 [LYS] C:1 [U] ✔
A:368 [THR] B:7 [U] A:368 [THR] C:7 [G] ✔
A:760 [SER] B:6 [A] A:760 [SER] C:6 [A] ✔
A:792 [ARG] B:3 [C] A:792 [ARG] C:3 [C] ✔
A:792 [ARG] B:4 [A] A:792 [ARG] C:4 [A] ✔
A:761 [ARG] B:6 [A] A:761 [ARG] C:6 [A] ✔
A:761 [ARG] B:7 [U] A:761 [ARG] C:7 [G] ✔
A:761 [ARG] B:8 [U] A:761 [ARG] C:8 [U] ✔
A:365 [ILE] D:25 [U] A:365 [ILE] E:24 [U] ✔
A:365 [ILE] D:26 [G] A:365 [ILE] E:25 [G] ✔
A:758 [GLY] B:6 [A] A:758 [GLY] C:6 [A] ✔
A:759 [THR] B:6 [A] A:759 [THR] C:6 [A] ✔
A:759 [THR] B:7 [U] A:759 [THR] C:7 [G] ✔
A:795 [ARG] B:4 [A] A:795 [ARG] C:4 [A] ✔
A:551 [ASN] B:2 [U] A:551 [ASN] C:2 [U] ✔
A:546 [CYS] B:1 [U] A:546 [CYS] C:1 [U] ✔
A:546 [CYS] B:2 [U] A:546 [CYS] C:2 [U] ✔
A:544 [THR] B:1 [U] A:544 [THR] C:1 [U] ✔
A:548 [GLN] B:1 [U] A:548 [GLN] C:1 [U] ✔
A:548 [GLN] B:2 [U] A:548 [GLN] C:2 [U] ✔
A:525 [LYS] B:1 [U] A:525 [LYS] C:1 [U] ✔
A:525 [LYS] D:23 [A] A:525 [LYS] E:22 [U] ✔
A:525 [LYS] D:24 [A] A:525 [LYS] E:23 [C] ✔
A:361 [THR] D:25 [U] A:361 [THR] E:24 [U] ✔
A:533 [LYS] B:1 [U] A:533 [LYS] C:1 [U] ✔
A:524 [GLY] B:1 [U] A:524 [GLY] C:1 [U] ✔
A:709 [LYS] B:5 [C] A:709 [LYS] C:5 [C] ❌ 6MFN_A_C,E
A:710 [ARG] B:9 [G] A:710 [ARG] C:9 [G] ❌ 6MFN_A_C,E
A:760 [SER] B:5 [C] A:760 [SER] C:5 [C] ❌ 6MFN_A_C,E
A:365 [ILE] B:6 [A] A:365 [ILE] C:6 [A] ❌ 6MFN_A_C,E
A:365 [ILE] B:7 [U] A:365 [ILE] C:7 [G] ❌ 6MFN_A_C,E
A:361 [THR] D:24 [A] A:361 [THR] E:23 [C] ❌ 6MFN_A_C,E
A:177 [VAL] B:9 [G] A:177 [VAL] C:9 [G] ❌ 4W5O_A_B,D
A:368 [THR] B:8 [U] A:368 [THR] C:8 [U] ❌ 4W5O_A_B,D
A:551 [ASN] B:1 [U] A:551 [ASN] C:1 [U] ❌ 4W5O_A_B,D
A:558 [GLN] D:31 [A] A:558 [GLN] E:29 [U] ❌ 4W5O_A_B,D
A:714 [ARG] B:6 [A] A:714 [ARG] C:6 [A] ❌ 4W5O_A_B,D
A:757 [GLN] B:4 [A] A:757 [GLN] C:4 [A] ❌ 4W5O_A_B,D
A:757 [GLN] D:28 [G] A:757 [GLN] E:27 [G] ❌ 4W5O_A_B,D
A:758 [GLY] B:7 [U] A:758 [GLY] C:7 [G] ❌ 4W5O_A_B,D
A:811 [PHE] D:23 [A] A:811 [PHE] E:22 [U] ❌ 4W5O_A_B,D
A:438 [ARG] D:31 [A] A:438 [ARG] E:29 [U] ❌ 6MFN_A:438 no longer at interface
A:357 [THR] D:24 [A] A:357 [THR] E:23 [C] ❌ 6MFN_A:357 no longer at interface
A:602 [PRO] B:9 [G] A:602 [PRO] C:9 [G] ❌ 6MFN_A:602 no longer at interface
A:358 [ASP] D:24 [A] A:358 [ASP] E:23 [C] ❌ 6MFN_A:358 no longer at interface
A:358 [ASP] D:25 [U] A:358 [ASP] E:24 [U] ❌ 6MFN_A:358 no longer at interface
A:362 [SER] D:25 [U] A:362 [SER] E:24 [U] ❌ 6MFN_A:362 no longer at interface
A:362 [SER] D:26 [G] A:362 [SER] E:25 [G] ❌ 6MFN_A:362 no longer at interface
A:220 [SER] B:8 [U] A:220 [SER] C:8 [U] ❌ 4W5O_A:220 no longer at interface
A:355 [LYS] D:24 [A] A:355 [LYS] E:23 [C] ❌ 4W5O_A:355 no longer at interface
A:369 [ALA] B:7 [U] A:369 [ALA] C:7 [G] ❌ 4W5O_A:369 no longer at interface
A:369 [ALA] B:6 [A] A:369 [ALA] C:6 [A] ❌ 4W5O_A:369 no longer at interface
A:814 [ARG] D:23 [A] A:814 [ARG] E:22 [U] ❌ 4W5O_A:814 no longer at interface

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Properties of this pair

Common ECOD label(s)
 Common RFAM label(s)
 Interface TM-score
 Interface RMSD
 Percentage identity
 Protein TM-score
 RNA TM-score
 Protein coverage
 RNA coverage
 Percentage conservation
 Apolar conservation
 H-bond conservation
 Percentage switching out
Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs 0.92 1.55 0.76 0.92 0.39 0.93 1.0 0.85 0.74 0.45 0.44


Other pairs involving 4W5O_A_B,D or 6MFN_A_C,E

Total number of entries: 34

Interface 1 Interface 2 Percentage conservation
 		Interface TM-score
 		Interface RMSD
 		Percentage identity
 		Common ECOD label(s)
 		Common RFAM label(s)
 		Explore both interfaces
4OLA_A_B 6MFN_A_C,E 0.88 0.86 1.81 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4OLA_A_B 4W5O_A_B,D 0.92 0.92 3.08 0.2 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
6MFN_A_C,E 6OZP_A_C,D 0.59 0.61 2.53 0.1 Ribonuclease H-like compare
6MFN_A_C,E 6OON_A_B 0.88 0.89 1.67 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6MFN_A_C,E 6OZP_B_C,D 0.47 0.63 2.56 0.05 Ribonuclease H-like compare
6MFN_A_C,E 6OZS_A_C,D 0.59 0.61 2.51 0.1 Ribonuclease H-like compare
6MFN_A_C,E 6OZS_B_C,D 0.42 0.63 2.57 0.09 Ribonuclease H-like compare
4KXT_A_B 4W5O_A_B,D 0.87 0.91 3.12 0.17 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 compare
4KXT_A_B 6MFN_A_C,E 0.90 0.85 1.72 0.17 Ribonuclease H-like & Argonaute, N-terminal domain compare
4KRE_A_R 6MFN_A_C,E 0.86 0.87 1.83 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4KRE_A_R 4W5O_A_B,D 0.84 0.94 2.22 0.09 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
6D92_A_C 6MFN_A_C,E 0.65 0.7 2.72 0.12 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
5JS1_A_B 6MFN_A_C,E 0.86 0.86 1.83 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
5AWH_A_C 6MFN_A_C,E 0.67 0.7 2.74 0.18 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4Z4D_A_B,D 6MFN_A_C,E 0.85 0.92 1.69 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5O_A_B,D 5JS1_A_B 0.88 0.92 3.24 0.4 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZS_A_C,D 0.44 0.61 2.76 0.15 Ribonuclease H-like compare
4W5O_A_B,D 5I4A_A_B 0.39 0.78 2.71 0.03 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6MFN_A_C,E 0.85 0.92 1.55 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4W5O_A_B,D 5AWH_A_C 0.59 0.71 3.99 0.16 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZP_A_C,D 0.57 0.61 2.77 0.15 Ribonuclease H-like compare
4W5O_A_B,D 6OON_A_B 0.90 0.96 1.89 0.33 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4Z4D_A_B,D 0.96 1.0 0.12 0.96 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6D92_A_C 0.59 0.71 4.07 0.11 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 4W5T_A_B,D 0.94 0.99 0.26 0.92 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6CBD_A_B,C 0.99 1.0 0.36 0.97 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5O_A_B,D 6OZP_B_C,D 0.48 0.63 2.71 0.1 Ribonuclease H-like compare
4W5O_A_B,D 6OZS_B_C,D 0.49 0.63 2.78 0.14 Ribonuclease H-like compare
4KRF_A_R 6MFN_A_C,E 0.87 0.86 1.85 0.08 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4KRF_A_R 4W5O_A_B,D 0.86 0.92 2.36 0.25 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4W5T_A_B,D 6MFN_A_C,E 0.83 0.93 1.53 0.59 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
4F3T_A_R 4W5O_A_B,D 0.68 0.92 3.24 0.14 Ribonuclease H-like & Argonaute, N-terminal domain & SH3 & Middle domain in Argonaute homologs compare
4F3T_A_R 6MFN_A_C,E 0.84 0.85 1.9 0.21 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare
6CBD_A_B,C 6MFN_A_C,E 0.83 0.92 1.43 0.76 Ribonuclease H-like & Argonaute, N-terminal domain & Middle domain in Argonaute homologs compare